Abrégé

The invention relates to a monosubstituted or disubstituted potassium salt of the peptide HAEE, where HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu. The present invention further relates to a method (and variants thereof) for producing potassium salts of the peptide HAEE, pharmaceutical compositions based on potassium salts of the peptide HAEE, and the use of potassium salts of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

mnn, where Cu is a doubly-charged copper (II) cation, m=1 for singly-charged and doubly-charged anions, m=3 for triply-charged anions, HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu, X is a pharmaceutically acceptable anion, n=1 for doubly-charged anions, and n=2 for singly-charged and triply-charged anions. The present invention further relates to a method for producing a copper complex of the peptide HAEE, pharmaceutical compositions based on a copper complex of the peptide HAEE, and the use of a copper complex of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

mnn, where Mg is a doubly-charged magnesium (II) cation, m=1 for singly-charged and doubly-charged anions, m=3 for triply-charged anions, HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu, X is a pharmaceutically acceptable anion, n=1 for doubly-charged anions, and n=2 for singly-charged and triply-charged anions. The present invention further relates to a method for producing a magnesium complex of the peptide HAEE, pharmaceutical compositions based on a magnesium complex of the peptide HAEE, and the use of a magnesium complex of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

The invention relates to a monosubstituted or disubstituted sodium salt of the peptide HAEE, where HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu. The present invention further relates to a method (and variants thereof) for producing sodium salts of the peptide HAEE, pharmaceutical compositions based on sodium salts of the peptide HAEE, and the use of sodium salts of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

mnn, where Zn is a doubly-charged zinc (II) cation, m=1 for singly-charged and doubly-charged anions, m=3 for triply-charged anions, HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu, X is a pharmaceutically acceptable anion, n=1 for doubly-charged anions, and n=2 for singly-charged and triply-charged anions. The present invention further relates to a method for producing a zinc complex of the peptide HAEE, pharmaceutical compositions based on a zinc complex of the peptide HAEE, and the use of a zinc complex of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

The invention relates to a monosubstituted or disubstituted ammonium salt of the peptide HAEE, where HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu. The present invention further relates to a method (and variants thereof) for producing ammonium salts of the peptide HAEE, pharmaceutical compositions based on ammonium salts of the peptide HAEE, and the use of ammonium salts of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

mnn, where Ca is a doubly-charged calcium (II) cation, m=1 for singly-charged and doubly-charged anions, m=3 for triply-charged anions, HAEE is a synthetic peptide that is acetylated at the N-terminus and amidated at the C-terminus and has the amino acid sequence His-Ala-Glu-Glu, X is a pharmaceutically acceptable anion, n=1 for doubly-charged anions, and n=2 for singly-charged and triply-charged anions. The present invention further relates to a method for producing a calcium complex of the peptide HAEE, pharmaceutical compositions based on a calcium complex of the peptide HAEE, and the use of a calcium complex of the peptide HAEE for treating neurodegenerative diseases.

Classes IPC  ?

• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• A61K 38/07 - Tétrapeptides
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence