Abrégé

The present invention relates to compounds of the formula (I′), especially compounds of formula (I), a process for their preparation and their use as almost colourless IR absorbers, for optical filter applications, especially for plasma display panels, or for laser welding of plastics. The compounds may be used in compositions for inks, paints and plastics, especially in a wide variety of printing systems and are particularly well-suited for security applications, or for brand protection; or as marker for liquid. Compounds of formula (I′), especially compounds of formula (I), represent almost colourless IR absorbers, which exhibit high resistance against chemicals and solvents as well as good light stability and good thermal stability. Due to their unique application properties they can be advantageously employed as IR absorbers for laser writing, heat shielding, security printing, the laser-welding of plastics and as marker for liquids.

Classes IPC  ?

• C07D 487/04 - Systèmes condensés en ortho
• C09B 5/62 - Imides ou amidines cycliques d'acides péridicarboxyliques des séries de l'anthracène, du benzanthrène ou du perylène
• C09D 11/03 - Encres d’imprimerie caractérisées par des particularités autres que la nature chimique du liant

Abrégé

The present invention relates to an inorganic-organic hybrid compound as ionic compound, composed of an inorganic metal cation selected from [ZrO]2+, and of an organic active ingredient anion selected from gemcitabine monophosphate or gemcitabine triphosphate.

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo
• A61K 9/51 - Nanocapsules
• A61K 31/7068 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc

Abrégé

The present invention is directed to formulations comprising a water-immiscible fluorocarbon solvent and at least one amphiphilic polymer, wherein the least one amphiphilic polymer is selected from a diblock co-polymer surfactant of formula A-B and a triblock co-polymer surfactant of formula B'-A'-B', wherein A and A' independently of each other represent a water-soluble polymer block having a weight average molecular weight in the range of 300 g/mol to 2000 g/mol, and B and B' represent independently of each other a perfluorinated polyether block having a weight average molecular weight in the range of 1500 g/mol to 7500 g/mol. Said formulations exhibit improved properties which render them particularly useful in droplet-based microfluidics applications, including the construction of lipid vesicles, cell encapsulation and monitoring, and droplet digital molecular biology.

Classes IPC  ?

• C09K 23/42 - Éthers, p. ex. éthers polyglycoliques d'alcools ou de phénols
• C11D 1/72 - Éthers de polyoxyalkylèneglycols
• C11D 3/43 - Solvants

Abrégé

The present invention is directed towards catalysts comprising magnetic particles and metal particles on a support, as well as methods of hydrogenating substrates utilising such catalysts. In particular, a method employing such catalysts to hydrogenate amides is claimed. The catalysts and methods of the present invention improve upon the disadvantages associated with literature hydrogenation reactions and in particular, allow hydrogenation reactions under mild conditions.

Classes IPC  ?

• B01J 27/22 - Carbures
• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général
• B01J 35/33 - Propriétés électriques ou magnétiques
• B01J 35/45 - Nanoparticules
• C07C 1/00 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure
• C07C 5/00 - Préparation d'hydrocarbures à partir d'hydrocarbures contenant le même nombre d'atomes de carbone
• C07D 203/00 - Composés hétérocycliques contenant des cycles à trois chaînons ne comportant qu'un seul atome d'azote comme unique hétéro-atome du cycle

Abrégé

For adapting optical properties of a continuous body arranged in a resonator cavity and comprising a nonlinear optical material to light of two different wavelengths passing through the continuous body along an optical axis, the continuous body having a total length along the optical axis, a spatially constant temperature is adjusted in a first region of the continuous body, the first region extending over at least 20% of the total length, and a temperature gradient is adjusted in a second region of the continuous body, the second region neighboring the first region and extending over at least 10% of the total length. The temperature gradient may be selected such as to achieve resonance of the light of both wavelengths in the resonator cavity.

Classes IPC  ?

• G02F 1/35 - Optique non linéaire

Abrégé

A catalytic one-pot process for the preparation of an alcohol is provided. The process comprises decomposition of methanol into synthesis gas, the hydroformylation of an optionally substituted alkene using said synthesis gas and hydrogenation to the corresponding alcohol. The catalyst system combines a hydroformylation catalyst and a transition metal complex catalyst.

Abrégé

The present invention relates to photo-Elecerochemical devices comprising an electron storage material (ESM), the use of an electron storage material or of a device comprising it, a method for the photocatalytic production of a product, an autophotorechargable Battery, a method for detecting oxygen, a method for detecting light, and a method for detecting an Analyte. The ESM has a structure containing oxygen and at least one selected from the transition metals of Groups 4, 5, 6 or 7 of the Periodic Table of the Elements and the lanthanides, and is capable of producing electron-hole pairs when irradiated by light. The thereby generated electrons can be stored in the ESM and can be extracted after irradiation has stopped.

Classes IPC  ?

• H01M 14/00 - Générateurs électrochimiques de courant ou de tension non prévus dans les groupes Leur fabrication
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
• C25B 9/17 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure
• C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
• C25B 11/087 - Composé photo-catalytique

Abrégé

The invention relates to a method and a device for reducing a local thermal load on a surface of a particle collection device that is struck by electrically charged particles. The electrically charged particles may correspond in particular to a fraction of non-neutralised ions from a particle beam of neutralised ions downstream of a neutraliser of a neutral beam injection device of a fusion reactor. The method comprises changing, preferably continuously, the point of impact (P) of the charged particles (8) on the surface (34) by exposing the charged particles (8) to at least one magnetic and/or electric field, the field lines of which are oblique or perpendicular to a flight direction of the charged particles and the field strength of which is varied, preferably continuously, in order to change the point of impact (P) so as to reduce a local thermal load on the surface (34), the surface (34) being designed as an area with an open cross-section.

Classes IPC  ?

• H05H 6/00 - Cibles pour la production de réactions nucléaires

Abrégé

NNin vitroin vivoNNNNN-acylneuraminate cytidylyltransferase (CSS), optional a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3).

Classes IPC  ?

• C12P 19/18 - Préparation de composés contenant des radicaux saccharide préparés par action d'une transférase glycosylique, p. ex. alpha-, bêta- ou gamma-cyclodextrines
• C12N 9/10 - Transférases (2.)
• C12P 21/00 - Préparation de peptides ou de protéines
• C12P 19/26 - Préparation d'hydrates de carbone contenant de l'azote

Abrégé

ΦtΩωΩωΦtt)) for the laser pulse such as to minimize an effect of a photon recoil of the trapped particle induced by said laser pulse on a gate fidelity of the quantum gate, as well as to a corresponding method for performing an arbitrary quantum gate as well as to a system for modulating laser pulses used to implement one or more quantum gates for a subset of qubits in a quantum register, and to a quantum computer.

Classes IPC  ?

• G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit

Abrégé

In a thermal anemometry method of measuring a flow velocity of a flowing fluid, a probe is arranged in the flowing fluid. An electric current is passed through the probe to heat up the probe to a temperature that is higher than an ambient temperature. An amperage of the electric current through the heated probe and a voltage dropping over the heated probe are measured, while the electric current heating up the probe is passed through the heated probe. The flow velocity is determined using the temperature of the heated probe, a change in the temperature of the heated probe and an electric power supplied to the heated probe by the electric current, which are all determined from the amperage and the voltage, and using a heat capacity of the heated probe.

Classes IPC  ?

• G01F 1/69 - Dispositions de structureMontage des éléments, p. ex. relativement à l'écoulement de fluide utilisant un élément de chauffage, de refroidissement ou de détection d'un type particulier du type à résistance

Abrégé

Proteasome inhibitors of formula (I), wherein the meanings for the various substituents are as disclosed in the description.

Classes IPC  ?

• C07K 5/087 - Tripeptides la chaîne latérale du premier amino-acide contenant des carbocycles, p. ex. Phe, Tyr
• C07K 5/107 - Tétrapeptides la chaîne latérale du premier amino-acide contenant des carbocycles, p. ex. Phe, Tyr
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to a device for water-in-air generation of droplets comprising a collection vessel, a droplet generation device positioned above the collection vessel comprising a piezoelectric transducer (21) and at least one capillary (22) with a nozzle (23) pointing downwards to the collection vessel; a laser source (30) generating a visible light laser beam (31) with tophat profile, and an imaging setup for continuously monitoring the droplet generation (40). Said device is particularly useful for preparing monodisperse giant unilamellar vesicles of any composition and three-dimensional microenvironment niches for cells or synthetic cells in high throughput.

Classes IPC  ?

• B01J 13/04 - Fabrication de microcapsules ou de microbilles par des procédés physiques, p. ex. séchage, pulvérisation

Abrégé

Plasmodium falciparumPlasmodium falciparum.

Classes IPC  ?

• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• A61P 33/06 - Antipaludéens
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

The present invention relates to an improved multi-photon lithography process, which allows verification and control of the result of the lithography process while the process is running (real-time verification and control) and optionally full 3D digital reconstruction of the final fabricated structure. The invention further relates to multi-photon lithography equipment and systems used to implement the foregoing processes.

Classes IPC  ?

• B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
• B29C 64/135 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque la source d’énergie étant concentrée, p. ex. lasers à balayage ou sources lumineuses focalisées
• B29C 64/268 - Agencements pour irradiation par faisceaux laserAgencements pour irradiation par faisceaux d’électrons [FE]
• B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
• B33Y 10/00 - Procédés de fabrication additive
• B33Y 50/00 - Acquisition ou traitement de données pour la fabrication additive
• B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive

Abrégé

eraliaalia, compositions, polypeptides, and kits for carrying out the herein provided methods.

Classes IPC  ?

• C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
• C12N 9/10 - Transférases (2.)
• C07K 19/00 - Peptides hybrides
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées

Abrégé

The present invention relates to an electrochemical device, comprising a negative electrode comprising a nitrogen-containing electron storage material, a positive electrode, and an electrolyte, wherein the nitrogen-containing electron storage material has a two-dimensional or a three-dimensional covalent structure, contains heptazine and/or triazine moieties, and is capable of intercalating and de-intercalating cations. The present invention is further directed to a uses the material, a photorechargeable battery, an autophotorechargeable battery, a redox-flow-battery, a method for harvesting light and storing electrical energy, a method for detecting and removing oxygen, and a method for detecting light.

Classes IPC  ?

• H01M 14/00 - Générateurs électrochimiques de courant ou de tension non prévus dans les groupes Leur fabrication
• H01M 4/13 - Électrodes pour accumulateurs à électrolyte non aqueux, p. ex. pour accumulateurs au lithiumLeurs procédés de fabrication
• H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques

Abrégé

The present invention relates to a modified crop plant or part thereof which exhibits increased or ectopic expression of one or more one transcription factors, which one or more transcription factors are specifically expressed in the plant's ESR and/or in the plant's BETL, or modulate gene expression of one or more ESR and/or BETL-specific genes.

Classes IPC  ?

• C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
• C12N 9/22 - Ribonucléases
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

Provided is a computer-implemented method for generating a dynamics model of a system. The method comprises generating the dynamics model, optionally including an IMC, by determining unknown dynamics of the system using a predetermined kernel-based method designed for regression and/or classification, optionally BTGP regression. Generating the dynamics model comprises computing probability bounds for each transition or multiple transitions of the dynamics model by obtaining transition probability distributions from the kernel-based method that are amenable to a predefined model checking algorithm, and determining an abstraction error of the model based on the computed probability bounds.

Classes IPC  ?

• G05B 17/02 - Systèmes impliquant l'usage de modèles ou de simulateurs desdits systèmes électriques

Abrégé

23(B322RR).

Classes IPC  ?

• C25B 3/26 - Réduction du dioxyde de carbone
• C25B 11/042 - Électrodes à base d’un seul matériau

Abrégé

The invention relates to a method for determining a temperature (70) of a source material (20) of a TLE system (10) by a temperature determination system (30) comprising an optical detector system (40) and a processing unit (60), wherein the optical detector system (40) comprises a camera unit (42) for capturing images (46) of a thermal radiation (32) of the source material (20) and further comprises optical elements (50) for transferring and/or altering the emitted thermal radiation (32) between the source material (20) and the camera unit (42), wherein the processing unit (60) is constructed for analyzing the images (46) captured by the optical detector system (40), wherein said analysis includes determining an intensity (80) of the thermal radiation (32) of the source material (20) in the images (46) captured by the optical detector system (40) and determining the temperature (70) of the source material (20) based on said determined intensity (80) by using a calibration. Further, the invention relates to a temperature determination system (30) capable of carrying out said method, and to a TLE system (10) comprising said temperature determination system (30).

Classes IPC  ?

• G01J 5/00 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique
• G01J 5/52 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant la comparaison avec des sources de référence, p. ex. pyromètres à disparition de filament

Abrégé

The present invention relates to a polypeptide configured to assemble into a binder of granulocyte-colony stimulating factor receptor (G-CSFR), a protein comprising said polypeptide, a nucleic acid molecule encoding said polypeptide or protein, an expression vector comprising the nucleic acid molecule, a recombinant host cell comprising said polypeptide, protein, nucleic acid molecule and/or expression vector, a pharmaceutical composition comprising the said polypeptide, protein, nucleic acid molecule, expression vector and/or host cell, and to a kit.

Classes IPC  ?

• A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/18 - Facteurs de croissanceRégulateurs de croissance
• C07K 14/535 - CSF du type granulocyteCSF du type granulocyte-macrophage

Abrégé

The present invention relates to a therapeutic oligonucleotide for use in treating a disease in a subject that is associated with or caused by a missense, nonsense or in-frame indel mutation in a gene of the genome of the subject, wherein the therapeutic oligonucleotide is capable of specifically hybridizing to the 5'-splice site, the 3'-splice site or an exonic splicing enhancer (ESE) of an out-of- frame exon in the gene with the missense, nonsense or in-frame indel mutation, thereby causing skipping of the out-of-frame exon.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides

Abrégé

The present invention relates to a cell-free enzyme-catalyzed process for producing glycoproteins of general formula (I) from a lipid-linked oligosaccharide and a peptide. Further, said process includes the construction of the lipid-linked oligosaccharide from a mannose trisaccharide containing core structure. Particularly, the lipid-linked oligosaccharide is a high mannose-, complex-, or hybrid-type N-glycan.

Classes IPC  ?

• C12P 21/00 - Préparation de peptides ou de protéines
• C12N 9/10 - Transférases (2.)
• C12P 19/38 - Nucléosides

Abrégé

The present invention relates to an agent that inhibits the expression or activity of the G Protein-Coupled Receptor 182 (GPR182) protein for use in the treatment or prevention of a pathological condition selected from myocardial infarction, myocardial ischemia, myocardial necrosis, cardiac hypertrophy, cardiac fibrosis, limb ischemia, ischemia-related tissue degeneration, stroke and a cancer, wherein (a) the agent that inhibits the expression of the GPR182 protein is selected from an siRNA, miRNA, shRNA, a ribozyme and an antisense nucleic acid molecule; and/or (b) the agent that inhibits the activity of the GPR182 protein specifically binds to the GPR182 protein and inhibits binding of one or more endogenous ligands to the GPR182 protein, and wherein the agent is selected from an antibody, an Fc fusion polypeptide, an adnectin, an affibody, an affilin, an anticalin, an atrimer, an avimer, an evibody, a Kunitz-type domain, a designed ankyrin repeat protein (DARPin), a fynomer, a peptide or peptidomimetic, an aptamer, and a small molecule; or any combination and/or hetero-or homo-oligomeric, covalent or non-covalent complex thereof.

Classes IPC  ?

• C07K 14/52 - CytokinesLymphokinesInterférons
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

εtt is the strain along the normal to the plane of the deposited film, and further to the materials so prepared and to their use in spintronics technology.

Classes IPC  ?

• H01F 41/30 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour appliquer des pellicules magnétiques sur des substrats pour appliquer des structures nanométriques, p. ex. en utilisant l'épitaxie par jets moléculaires [MBE]
• H01F 10/16 - Métaux ou alliages contenant du cobalt
• H01F 10/30 - Pellicules magnétiques minces, p. ex. de structure à un domaine caractérisées par le substrat ou par les couches intermédiaires caractérisées par la composition des couches intermédiaires

Abrégé

A method of manufacturing a hollow core cane, the method comprising: assembling a preform comprising a jacket with a hollow inner structure, wherein a plurality of capillaries are located within the hollow inner structure, the preform having a first end and a second end; creating a tapered portion of the preform at the first end; slicing the preform within the tapered portion to thereby create a sliced end of the preform and expose cavities of the plurality of capillaries and the hollow inner structure; inserting a pressurization tube into one or more of the cavities at the sliced end of the preform; sealing the least one pressurization tube within the one or more cavities with a sealing agent; coupling the least one pressurization tube to a pressure connector; and drawing a hollow core cane from the preform whilst providing pressure to the one or more cavities using the pressure connector.

Classes IPC  ?

• C03B 37/012 - Fabrication d'ébauches d'étirage de fibres ou de filaments
• C03B 37/027 - Fibres constituées de différentes variétés de verre, p. ex. fibres optiques

Abrégé

Described herein is a modular polypeptide comprising a first partial effector sequence comprising a first part of a circular permutated halotag protein connected to a sensor module sequence, which is connected to a second part of a circular permutated halotag protein. The sensor module is a single polypeptide or a polypeptide pair capable of undergoing conformational change from a first confirmation to a second confirmation depending on the presence or concentration of an analyte compound. The modular peptide is catalytically active in response to an environmental stimulus or in response to the sensor pair interacting. Additionally, described herein are nucleic acid sequences encoding the modular polypeptide, and to kits comprising same.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase

Abrégé

The present invention relates to an electrochemical device, comprising a negative electrode comprising a nitrogen-containing electron storage material, a positive electrode, and an electrolyte, wherein the nitrogen-containing electron storage material has a two-dimensional or a three-dimensional covalent structure, contains heptazine and/or triazine moieties, and is capable of intercalating and de-intercalating cations. The present invention is further directed to a uses the material, a photorechargeable battery, an autophotorechargeable battery, a redox-flow-battery, a method for harvesting light and storing electrical energy, a method for detecting and removing oxygen, and a method for detecting light.

Classes IPC  ?

• H01M 14/00 - Générateurs électrochimiques de courant ou de tension non prévus dans les groupes Leur fabrication
• H01M 4/13 - Électrodes pour accumulateurs à électrolyte non aqueux, p. ex. pour accumulateurs au lithiumLeurs procédés de fabrication
• H01M 4/60 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs de composés organiques

Abrégé

ndhnuoldhAmqonuonuoAnuoBnuoCnuoDnuoEnuoFnuoGnuoHnuoInuoJnuoKnuoLnuoMnuoNnuoN; wherein the genetically engineered bacterium is capable of biosynthesizing a chinone species endogenously, preferably ubiquinone; and wherein the genetically engineered bacterium is capable of expressing one or more ubiquinol oxidases (H+-transporting) and/or quinol oxidases (electrogenic, proton-motive force generating) endogenously. The genetically engineered bacterium is only able to grow if an external electron acceptor (substrate) and a corresponding NADH-consuming reaction are present. In this way, growth is directly coupled to a biotechnologically usable whole-cell catalysis. Thus, the growth of the genetically engineered bacterium of the present invention is absolutely dependent on the conversion of a substrate into an industrially interesting product.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• C12N 15/09 - Technologie d'ADN recombinant
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes
• C12P 7/58 - Acides aldoniques, céto-aldoniques ou sacchariques
• C12P 19/00 - Préparation de composés contenant des radicaux saccharide

Abrégé

A method implements a recurrent unit of a recurrent optical neural network via an optical waveguide. Laser pulse pairs are counter-propagated through the waveguide such that for a given pulse pair, a control signal pulse is coupled into a first ending of the waveguide and propagates towards a second end. A data signal pulse is coupled into the second end of the waveguide and propagates towards the first end. For a given pulse pair, an optical frequency of the data signal pulse is set to be within a bandwidth of a Brillouin frequency shift of the waveguide above an optical frequency of the control signal pulse of the same pulse pair, and a time delay between a first pulse pair and a subsequent second pulse pair is set to be less than a decay time of an acoustic wave generated by a stimulated Brillouin scattering process in the waveguide.

Classes IPC  ?

• G06N 3/067 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
• G06N 3/044 - Réseaux récurrents, p. ex. réseaux de Hopfield
• G06N 3/049 - Réseaux neuronaux temporels, p. ex. éléments à retard, neurones oscillants ou entrées impulsionnelles

Abrégé

The present invention relates to a method of producing cells having the phenotype of cardiac valve cells from precursor cells of valve cells comprising (a) introducing into said precursor cells early growth response 3 (EGR3) and/or a nucleic acid sequence encoding EGR3. The present invention also relates to a valve transplant comprising cells having the phenotype of valve cells obtained or obtainable by the method of the invention. The present invention furthermore relates to cells having the phenotype of valve cells obtained or obtainable by the method of the invention, the valve transplant of the invention or a compound promoting the expression and/or the activity of early growth response 3 (EGR3) for use in treating a subject having a valve defect.

Classes IPC  ?

• C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires

Abrégé

The present invention relates to a binding sensor comprising a mechanosensitive transmembrane ion channel connected to a first binding moiety capable of binding a first cognate binding partner, said first binding moiety being connected via a covalent linker.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

Three-dimensional (3D) network of metal fibers, comprising a plurality of metal fibers fixed to one another, wherein said plurality of metal fibers comprises a first kind of metal fibers and a second kind of metal fibers, wherein the first kind and second kind of metal fibers are different from one another, in particular in regard to their mechanical properties, wherein a plurality of the metal fibers of the first kind of metal fibers are connected to one another.

Classes IPC  ?

• D04H 1/4234 - Fibres métalliques
• B01D 39/06 - Substance inorganique, p. ex. fibres d'amiante, perles ou fibres de verre
• B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
• B22F 3/00 - Fabrication de pièces ou d'objets à partir de poudres métalliques, caractérisée par le mode de compactage ou de frittageAppareils spécialement adaptés à cet effet
• D04H 1/4382 - Fibres obtenues par étirage de film réticuléFibres compositesFibres mixtesFibres ultrafinesFibres pour cuir artificiel
• D04H 1/4391 - Non-tissés formés uniquement ou principalement de fibres coupées ou autres fibres similaires relativement courtes à partir de voiles ou couches composés de fibres ne possédant pas des propriétés cohésives réelles ou potentielles caractérisés par l'emploi de certaines sortes de fibres dans la mesure où cet emploi n'a pas d'influence prépondérante sur la consolidation du voile caractérisés par la forme des fibres
• H01M 4/66 - Emploi de matériaux spécifiés
• H01M 4/80 - Plaques poreuses, p. ex. supports frittés

Abrégé

The invention is in the technical field of assisted reproductive technologies. Mammalian eggs often contain an incorrect number of chromosomes, a condition referred to as aneuploidy. The inventors identified mechanisms that lead to aneuploidy in mammalian eggs, which guided the development of methods to prevent aneuploidy in mammalian oocytes and eggs. This invention relates to the in vitro introduction of several cohesion protection factors, such as Shugoshin (Sgo1), Shugoshin 2 (Sgo2), PP2A and/or pericentromeric RNA, individually and in combination, into the oocyte or egg, as these factors protect sister chromatid cohesion and thus reduce aneuploidy. Sgo1 and/or Sgo2 are also described for use in a method of preventing chromosomal aberrations.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12N 5/075 - OocytesOogonies
• C12N 15/89 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-injection

Abrégé

The present invention refers to a method for generating a binodal curve of a polymer in a system by determining accurate values of both concentration of dilute and condensed phases of a polymer, in particular, protein or polynucleic acid, under different condition, such as at different temperatures and salt concentrations. Furthermore, the present invention refers to an assay method for identify bioactive compound(s), comprising the inventive method for generating a binodal curve of a polymer in a system.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

S. aureusS. aureus. These VHH antibodies are useful in an approach for co-neutralizing alpha- and gamma-hemolysins and the LukSF toxin pair by multimeric VHH-fusions. The invention provides an implementation of this approach.

Classes IPC  ?

• C07K 16/12 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• A61P 31/04 - Agents antibactériens

Abrégé

According to various aspects, a method is provided which comprises: receiving a three-dimensional reference image of a region in which an object to be manipulated is arranged, the three-dimensional reference image having a plurality of volume pixels; carrying out a three-dimensional rendering using the plurality of volume pixels in order to generate a rendered reference image; receiving one or more volume pixel coordinates for forming one or more target points in the rendered reference image; arranging the volume pixels of the three-dimensional reference image in discrete image layers; identifying, for each image layer, the volume pixels that are part of the target points in that image layer; generating image-layer-specific instructions for an action on the basis of the identified volume pixels; generating an instruction for starting a process and generating control information, the control information containing instructions for performing, in the region, the action for manipulating the object according to the target points; sending the instruction for starting the process and the control information to a manipulation device.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
• G06T 19/00 - Transformation de modèles ou d'images tridimensionnels [3D] pour infographie
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci

Abrégé

The present invention provides steroidal glycoalkaloids (SGA), and compositions including same. Further provided arc methods for synthesizing SGA, and using same.

Classes IPC  ?

• C12N 9/10 - Transférases (2.)
• A01P 7/04 - Insecticides
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

An anemometer has two prongs, each prong having a prong tip, and a hot-wire probe attached to the two prong tips and made of a section of a carbon nanotube fiber having an electric resistivity of not more than 25 μΩ·m and a positive thermal coefficient of resistivity of at least 1·10−3/K. Over an active length extending between the two prong tips, the hot-wire probe consists of the carbon nanotube fiber, and ends of the section of the carbon nanotube fiber extending along the prong tips are soldered to the prong tips.

Classes IPC  ?

• G01P 1/00 - Parties constitutives des instruments
• G01P 5/12 - Mesure de la vitesse des fluides, p. ex. d'un courant atmosphériqueMesure de la vitesse de corps, p. ex. navires, aéronefs, par rapport à des fluides en mesurant des variables thermiques en utilisant la variation de la résistance d'un conducteur chauffé

Abrégé

The present invention relates to a polypeptide configured to assemble into an inhibitor of vascular endothelial growth factor (VEGF), a protein comprising said polypeptide, a nucleic acid molecule encoding said polypeptide or protein, an expression vector comprising the nucleic acid molecule, a recombinant host cell comprising said polypeptide, protein, nucleic acid molecule and/or expression vector, a pharmaceutical composition comprising the said polypeptide, protein, nucleic acid molecule, expression vector and/or host cell, and to a kit.

Classes IPC  ?

• A61K 38/00 - Préparations médicinales contenant des peptides
• A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• A61K 38/18 - Facteurs de croissanceRégulateurs de croissance

Abrégé

The invention relates to alkylguanine transferase substrate molecules. In general formula (I) SB is a moiety that can be enzymatically cleaved from the rest of the molecule by an enzyme having an alkyltransferase activity selected from the group consisting of a 2-aminopyrimidinyl moiety, an aminopyridinyl moiety, and a 2-aminopurinyl moiety. Also described are molecules of general formula (II) and general formula (III) L is an optional linker, RN is H, methyl or ethyl or their deuterated or fluorinated derivatives, and R is selected from a detectable label and a selectively reactive moiety.

Classes IPC  ?

• C07D 213/06 - Composés hétérocycliques contenant des cycles à six chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle et avec au moins trois doubles liaisons entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques comportant trois liaisons doubles ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus de l'atome d'azote du cycle
• C07D 239/32 - Un atome d'oxygène, de soufre ou d'azote
• C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
• C07F 7/02 - Composés du silicium
• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
• A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes

Abrégé

The invention relates to a method for preparing an aqueous suspension of biodegradable, water-suspendable nanoparticles (1) with a peptide core and a polymer shell, wherein the nanoparticles (1) each provide a second-harmonic signal and a third-harmonic signal upon illumination, the method comprising the formation a of a miniemulsion to allow for self-assembly of the peptide core and subsequent removal of the organic phase to allow formation of the polymer shell in the aqueous phase

Classes IPC  ?

• A61K 49/00 - Préparations pour examen in vivo
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

A contrast agent composition comprising outer shells, each outer shell enclosing an outer filling that comprises a dispersion medium with one or more inner shell(s) dispersed in the dispersion medium. The inner shell(s) each enclose an inner filling that comprises at least one contrast agent. The inner filling has one property and the dispersion medium has the other property of the group of properties comprising lipophilic or lipophobic. At least one of the outer shell and the inner shell is formed by a layer of an outer surfactant arranged at the outer surface of the outer filling or an inner surfactant arranged at the outer surface of the inner filling, respectively. The contrast agent composition can be used in nuclear magnetic resonance imaging.

Classes IPC  ?

• A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes

Abrégé

The present invention relates to a method for generating an enriched population of early cortical neural stem cells (NSCs) or a subpopulation thereof, the method comprising: isolating cells that are positive for the cell surface marker protogenin (PRTG) from an initial population of neural progenitor cells, wherein said isolating is conducted at a time point between about day 4 and about day 12, preferably on day 5, after initiation of neural induction, thereby obtaining an enriched population of early cortical neural stem cells (NSCs); and optionally re- culturing said enriched population of early cortical neural stem cells (NSCs) in a neural induction medium or other culture medium, wherein said re-culturing preferably produces progeny of said early cortical neural stem cells (NSCs).

Classes IPC  ?

• C12N 5/0797 - Cellules souchesCellules progénitrices

Abrégé

The present invention relates to a polypeptide for use as a metal-binder, a protein comprising said polypeptide, a nucleic acid molecule encoding said polypeptide or protein, an expression vector comprising the nucleic acid molecule, a recombinant host cell comprising said polypeptide, protein, nucleic acid molecule and/or expression vector, a pharmaceutical composition comprising the said polypeptide, protein, nucleic acid molecule, expression vector and/or host cell, and to a kit.

Classes IPC  ?

• C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
• A61K 51/08 - Peptides, p. ex. protéines

Abrégé

Porphyromonas gingivalisPorphyromonas gingivalisPorphyromonas gingivalis bacteria. Another aspect of the present invention is directed to a monoclonal antibody having specificity for a synthetic saccharide of general formula (I).

Classes IPC  ?

• C07H 15/04 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'oxygène d'un radical saccharide
• C07H 15/12 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'azote d'un radical saccharide
• C07K 16/12 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de bactéries
• A61P 1/02 - Préparations stomatologiques, p. ex. médicaments pour le traitement des caries, des aphtes, des périodontites
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61K 31/70 - Hydrates de carboneSucresLeurs dérivés

Abrégé

The present invention relates to a metal fiber having an anisotropic surface texture, comprising: a first end region on a first end of the metal fiber having a smooth surface; and a second end region on a second end of the metal fiber having a non-smooth surface.

Classes IPC  ?

• B22F 1/062 - Particules fibreuses
• B22F 3/00 - Fabrication de pièces ou d'objets à partir de poudres métalliques, caractérisée par le mode de compactage ou de frittageAppareils spécialement adaptés à cet effet
• B22F 3/10 - Frittage seul
• B22F 9/08 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau liquide par coulée, p. ex. à travers de petits orifices ou dans l'eau, par atomisation ou pulvérisation
• C25B 11/031 - Électrodes poreuses
• C25B 11/037 - Électrodes constituées de particules
• H01M 4/38 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'éléments simples ou d'alliages
• H01M 4/62 - Emploi de substances spécifiées inactives comme ingrédients pour les masses actives, p. ex. liants, charges
• H01M 4/66 - Emploi de matériaux spécifiés
• H01M 4/74 - Grillage ou matériau tisséMétal déployé
• H01M 4/80 - Plaques poreuses, p. ex. supports frittés
• H01M 8/0232 - Métaux ou alliages
• B22D 11/06 - Coulée continue des métaux, c.-à-d. en longueur indéfinie dans des moules dont les parois se déplacent, p. ex. entre des rouleaux, des plaques, des courroies, des chenilles
• B22D 23/00 - Procédés de coulée non prévus dans les groupes

Abrégé

Method for determining rheological properties of deformable bodies, the method comprising leading the bodies in an immersion fluid through a microfluidic channel, measuring the deformation of those bodies by the forces exerted on the bodies due the hydrodynamic interactions with the surrounding fluid, determining the rheological properties of the bodies using the measurements, wherein the high frequency rheological properties of the bodies are determined using a truncated Fourier transform of the measurement data.

Classes IPC  ?

• G01N 15/10 - Recherche de particules individuelles
• G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines

Abrégé

A method of returning a fluorophore molecule from its non-fluorescence-excitable state to its fluorescence-excitable state, the method comprising the step of supplying the fluorophore molecule with electromagnetic radiation to stimulate a transition from the non-fluorescence- excitable state to the fluorescence-excitable state. The fluorophore transitions from its fluorescence-excitable state to its non-fluorescence-excitable state by means of a two-photon ionisation. The fluorophore is a nanographene. Moreover, uses of a nanographene fluorophore as a fluorophore in stimulated emission depletion microscopy and in calibrating a fluorescence imaging apparatus. Further, a recoverable fluorescence material comprising the fluorophore.

Classes IPC  ?

• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
• G01N 21/64 - FluorescencePhosphorescence
• C07C 15/00 - Hydrocarbures cycliques ne contenant que des cycles aromatiques à six chaînons en tant que partie cyclique

Abrégé

A method comprises simulating a shape of a rod-shaped portion resulting when at least one element located at a defined position at the rod-shaped portion having a defined size is subjected to a defined external magnetic field producing the external magnetic force using a FE model of the rod-shaped portion, determining a difference between the simulated shape and an at least one desired shape of the rod-shaped portion, the rod-shaped portion having the at least one desired shape being configured to be inserted into an anatomical structure of the human being and/or an animal, and adapting the defined position, the defined size and/or the defined external magnetic field based on the determined difference using an optimization method. The steps of simulating, determining, and adapting are carried out iteratively until the determined difference is below a defined threshold.

Classes IPC  ?

• A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
• A61B 17/29 - Pinces pour la chirurgie faiblement invasive
• A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
• A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters

Abrégé

The present invention relates to a method of forming a layer of a compound having a thickness selected in the range of a monolayer to several mm on a substrate, such as a single crystal wafer, the substrate being arranged in a process chamber comprising one or more sources of source material. The invention further relates to a compound optionally obtained by this method.

Classes IPC  ?

• C23C 16/448 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour produire des courants de gaz réactifs, p. ex. par évaporation ou par sublimation de matériaux précurseurs
• C23C 16/40 - Oxydes
• C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction

Abrégé

The present invention relates to a sound modulator for modifying the amplitude and/or phase of an ultrasonic wave comprising: a thermally-responsive material, wherein at least one acoustic property of the thermally-responsive material is variable in response to a change in temperature; a source of ultrasonic waves, which is suitable to emit an ultrasonic pulse or a continuous ultrasonic wave toward the thermally-responsive material; a tempering device, which is in thermal communication with the thermally-responsive material, to trigger a local change of at least one property of the thermally-responsive material; a control signal, which is suitable to control heating and/or cooling of the tempering device. Furthermore, the invention relates to a method for spatially and temporally modulate the amplitude and/or phase of an ultrasonic wave, comprising the steps of: transmitting an ultrasonic wave toward a thermally-responsive material of a sound modulator, wherein at least one acoustic property of the thermally-responsive material is variable in response to a change in temperature; transmitting a control signal to the sound modulator; and tempering one or a plurality of areas of the thermally-responsive material, in response to the control signal, causing a local change of an acoustic property of the thermally-responsive material.

Classes IPC  ?

• G10K 11/26 - Procédés ou dispositifs pour transmettre, conduire ou diriger le son pour focaliser ou pour diriger le son, p. ex. balayage
• G10K 15/04 - Dispositifs de production de sons
• A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores

Abrégé

The present invention relates to compounds of formula (I), processes for their preparation, and pharmaceutical compositions containing them as the active ingredient. Compounds of the present invention may be useful as mitochondrial KV1.3 inhibitors (mitoKV1.3) to treat cancer diseases and the like, including breast, colon, and prostate tumors, melanoma, smooth muscle, and skeletal muscle cancer, chronic lymphocytic leukemia, glioblastoma, and pancreatic ductal adenocarcinoma. The present invention relates to compounds of formula (I), processes for their preparation, and pharmaceutical compositions containing them as the active ingredient. Compounds of the present invention may be useful as mitochondrial KV1.3 inhibitors (mitoKV1.3) to treat cancer diseases and the like, including breast, colon, and prostate tumors, melanoma, smooth muscle, and skeletal muscle cancer, chronic lymphocytic leukemia, glioblastoma, and pancreatic ductal adenocarcinoma.

Classes IPC  ?

• C07F 9/6553 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle comportant des atomes de soufre, avec ou sans atomes de sélénium ou de tellure, comme uniques hétéro-atomes du cycle
• A61K 31/67 - Composés du phosphore ayant le soufre comme hétéro-atome d'un cycle
• A61P 35/00 - Agents anticancéreux
• C07F 9/54 - Composés de phosphonium quaternaire

Abrégé

The present invention relates to an optical optically controlled amplitude and/or phase modulator (1) for oscillating electrical signals comprising: a signal generator (2) suitable for providing an electrical input signal (4) oscillating with a frequency (6) between 20 kHz and 50 MHz; at least one light-responsive amplitude and /or phase modulation circuit (10) that out-puts an output signal (18) whose output signal amplitude and/or phase is governed by the intensity of light (32) incident upon the modulation circuit (10); and a light source(30) directed toward the modulation circuit (10). Furthermore, the invention relates to a method for generating multiple independent oscillating electrical signals (8, 18a – 18n, 38a – 38n) for driving an array of actuating elements (20a – 20n), comprising the steps of: generating an electrical input signal (4) oscillating with a frequency (6) between 20 kHz and 50 MHz by means of a signal generator (2); providing a multitude of independent light-responsive amplitude and/or phase modulation circuits (10a – 10n); providing the electrical input signal (2) to the multitude of independent light-responsive amplitude and/or phase modulation circuits (10a – 10n); and directing a controllable pattern of light (32, 320) toward the modulation circuits (10a – 10n).

Classes IPC  ?

• B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction

Abrégé

The present invention relates to a reading element for a racetrack memory (RTM) that includes two superconducting electrodes (S) made of a superconducting material, which electrodes are separated by a topological metal (N) with a spin-polarized surface state, which exhibits a band inversion. The invention further relates to a method of making such a reading element as well as to its use, specifically in a racetrack memory.

Classes IPC  ?

• G11C 19/32 - Mémoires numériques dans lesquelles l'information est déplacée par échelons, p. ex. registres à décalage utilisant des éléments supraconducteurs
• G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
• G11C 19/08 - Mémoires numériques dans lesquelles l'information est déplacée par échelons, p. ex. registres à décalage utilisant des éléments magnétiques utilisant des couches minces dans une structure plane
• H10B 61/00 - Dispositifs de mémoire magnétique, p. ex. dispositifs RAM magnéto-résistifs [MRAM]
• H10N 60/01 - Fabrication ou traitement
• H10N 60/12 - Dispositifs à effet Josephson
• H10N 60/80 - Détails de structure

Abrégé

An endoscope and a method for controlling a movement of the endoscope in a magnetic field, the endoscope comprising a tip, a set of coils surrounding the tip, and power wires arranged to supply the set of coils with electrical energy, wherein the set of coils comprises four side coils arranged around the tip such that a straight line extending orthogonally to a longitudinal direction of the tip crosses a center of the respective side coil.

Classes IPC  ?

• A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 18/08 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage à l'aide de sondes chauffées électriquement

Abrégé

The invention relates to an energy efficient non-volatile cryogenic memory (SUPERTRACK) which includes: a ferrimagnetic, ferromagnetic or synthetic antiferromagnetic racetrack (RT); and a superconducting shift element in proximity to the RT to move magnetic bits along the RT, wherein the superconducting shift element is a non-centrosymmetric superconductor, or is composed of a conventional superconducting material in proximity to a triplet converting material which converts the Cooper pairs of the conventional superconducting material into the triplet state, which material is selected from. Mn3X; X=Ge, Sn, Pb or Mn3XN, X=S, Ni, Ir. The invention relates to an energy efficient non-volatile cryogenic memory (SUPERTRACK) which includes: a ferrimagnetic, ferromagnetic or synthetic antiferromagnetic racetrack (RT); and a superconducting shift element in proximity to the RT to move magnetic bits along the RT, wherein the superconducting shift element is a non-centrosymmetric superconductor, or is composed of a conventional superconducting material in proximity to a triplet converting material which converts the Cooper pairs of the conventional superconducting material into the triplet state, which material is selected from. Mn3X; X=Ge, Sn, Pb or Mn3XN, X=S, Ni, Ir. Moreover, the invention relates to a method of manufacturing the memory and its use.

Classes IPC  ?

• H10B 61/00 - Dispositifs de mémoire magnétique, p. ex. dispositifs RAM magnéto-résistifs [MRAM]

Abrégé

The present invention relates to a microscope stage (100) for temperature-controlled live cell imaging comprising a cooling device (110), a heat transfer plate (1) having a cylinder (131) open on both ends for accommodating a Petri dish (3) and a heat sink (2) configured as support (120), wherein the cylinder (131) protrudes into a circularly shaped opening of the support (120). In a preferred embodiment, the microscope stage (100) comprises an objective heater (40) for preventing heat loss due to the microscope objective.

Classes IPC  ?

• C12M 1/22 - Boîtes de Pétri
• C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
• G01N 33/46 - Bois
• G02B 21/30 - Structure du bâti ou statif avec dispositif de réchauffage
• G02B 21/28 - Structure du bâti ou statif avec dispositif de réfrigération
• G01N 33/483 - Analyse physique de matériau biologique
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

The present invention relates to a guide RNA (gRNA) suitable for CRISPR-mediated oligonucleotide binding and/or editing comprising at least one hairpin that does not interact with a Cas enzyme wherein said hairpin forms a locked secondary structure.

Classes IPC  ?

• C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
• C12N 9/22 - Ribonucléases
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Abrégé

A modified nanoparticle for use in a therapeutic method, wherein the therapeutic method comprises the administration of the modified nanoparticle to an organism, the targeting of the modified nanoparticles to a specific site in the organism followed by an uptake of the modified nanoparticle into a cell, and wherein the modified nanoparticle is obtainable by a process comprising the steps of i) providing a nanoparticle and ii) contacting the nanoparticle with one or more antibodies as at a pH value of less than 7.0 so as to non-covalently bind the one or more antibodies via its/their Fc region onto the surface of the nanoparticle, wherein the nanoparticle provided in step i) is made of a material having at least one protonable or deprotonable group on the surface thereof and/or the one or more targeting moieties contacted with the nanoparticle in step ii) has at least one protonable or deprotonable group.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments

Abrégé

The present invention relates to a mannose-HSA based nanocarrier system, and a pharmaceutical composition containing the same for delivery of immunomodulatory drugs. The present invention further relates to a method of manufacturing said mannose-HSA nanocarrier system.

Classes IPC  ?

• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
• A61P 35/00 - Agents anticancéreux
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit

Abrégé

The present invention relates to means and methods for connectomic screening using 3D electron microscopy. In particular, the invention relates to a chaperone block for holding one or more biological tissue samples to be analyzed, imaged and/or screened (herein also referred to as "tissue sample of interest"), wherein the chaperone block comprises at least two layers of resin, at least one layer of a chaperone sample and a multitude of cavities. The "chaperone block" is a three dimensional structure for holding the biological tissue samples of interest during analysis, imaging and/or screening, particularly using 3D EM. The "chaperon sample" is also a biological tissue sample in which the biological tissue samples of interest will be embedded ("loaded") for analysis, imaging and/or screening, particularly using 3D EM. The invention also relates to a screening sample that can be loaded into a chaperone sample as well as an apparatus for loading a chaperone block with a screening sample. The "screening sample" is the biological tissue sample of interest that has been modified (incl. embedded in a resin) so that it can be loaded into the chaperone sample on the chaperone block for EM. Furthermore, the invention relates to methods to produce a chaperone block, methods to produce a screening sample and methods for preparing a tissue sample for connectomic screening.

Classes IPC  ?

• G01N 1/36 - Enrobage ou montage analogue d'échantillons

Abrégé

The present invention relates to the field of gene silencing. The present invention inter alia concerns circular RNAs, compositions and kits comprising circular RNAs, methods of producing circular RNAs, methods of inhibiting the expression of a target gene or the function of a target gene in a cell, and uses of circular RNAs and compositions comprising circular RNAs.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The present invention relates to a method for decapping a 5'-dinucleotide-capped nucleic acid molecule, wherein the dinucleotide is linked to the nucleic acid molecule via a phosphodiester bond and the dinucleotide comprises a diphosphate, triphosphate or tetraphosphate linkage between the two nucleotides of the dinucleotide, and wherein the method comprises contacting the 5'-dinucleotide- capped nucleic acid molecule with (I) an enzyme being capable of cleaving the diphosphate, triphosphate or tetraphosphate linkage, wherein the enzyme (a) comprises or consists of the amino acid sequence of SEQ ID NO: 21, (b) comprises or consists of an amino acid sequence being at least 80%, preferably at least 90% and most preferably at least 95% identical to SEQ ID NO: 21, (c) comprises or consists of the amino acid sequence being encoded by the nucleotide sequence of SEQ ID NO: 17, or (d) comprises or consists of an amino acid sequence being encoded by a nucleotide sequence being at least 80%, preferably at least 90% and most preferably at least 95% identical to SEQ ID NO: 17; (II) a nucleic acid molecule, preferably a vector, encoding in expressible form the enzyme of (I); and/or (III) a host cell comprising the nucleic acid molecule, preferably the vector of (II).

Classes IPC  ?

• C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
• C12N 9/14 - Hydrolases (3.)
• C12P 19/36 - Dinucléotides, p. ex. phosphate du dinucléotide de la nicotinamide-adénine

Abrégé

A method and apparatus for determining a chest function of a subject are provided. The method includes projecting, by a projector, a projection pattern including a number of optical markers onto a chest of the subject. The method further comprises capturing, by a stereo-camera system, a series of images of the projection pattern from at least two angles as the subject breathes. Each optical marker from the projection pattern is imaged from both of the at least two angles at the same time. The method further comprises tracking, by a processor, a movement over time of the projection pattern based on the captured series of images by tracking a movement over time of at least a subset of the optical markers in the captured series of images. The method also comprises determining, by the processor, at least one parameter indicative of the chest function of the subject based on a result of the tracking.

Classes IPC  ?

• A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre

Abrégé

The present invention relates to a method of detecting biomolecules in a sample, the method comprising: adding cells to the sample, the cells being arranged so that the biomolecules to be detected can interact with the cells to thus change one or more properties of the cells, detecting the properties of the cells, and comparing the detected properties with reference values to infer the presence or absence and/or concentration of the biomolecules.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The invention relates to a microscope comprising at least one light source for emitting light pulses for exciting a sample and an excitation beam path with a microscope objective for directing the light pulses on or into the sample, wherein the excitation beam path comprises a plurality of separate excitation channels being designed for guiding light pulses into in each case different focal spots on or in the sample, a distribution unit for distributing the light pulses to the excitation channels, a scanner for varying a region on or in the sample being irradiated by the light pulses, comprising further at least one detector for the detection of emission light emitted by the sample as an optical response to irradiation by the light pulses and a detection beam path for guiding the emission light onto the detector, and comprising a control unit for controlling at least the light source and the scanner and for evaluating the light detected by the detector. According to the invention, the microscope is characterized in that for temporally separating the respective optical responses from the irradiated focal spots, the excitation beam path is designed for irradiating the different focal spots through the excitation channels sequentially one after another, each of the excitation channels comprises an optical fiber having in each case an exit end, and, for guiding light pulses into the respectively different focal spots the exit ends of the optical fibers are arranged with an in each case different spacing with respect to a light focussing component of the excitation beam path. The invention relates furthermore to a microscopy method.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

Disclosed is a Janus microparticle (100). The Janus microparticle comprises at least a first portion (106) and a second portion (122). The first portion (106) comprises a ferromagnetic material and the second portion (122) comprises a piezoelectric material.

Classes IPC  ?

• H01F 1/00 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques

Abrégé

A strain measurement apparatus (100) for measuring mechanical strain in a sample (1) comprises a sample holder device (10) being arranged for accommodating the sample (1) to be investigated, an indenter device (20) including an indenter tip (21) and an actuator stage (22) carrying the indenter tip (21), wherein the actuator stage (22) is arranged for an application of a localized mechanical load along a load axis z1 via the indenter tip (21) at an indentation zone (2) of the sample (1) accommodated by the sample holder device (10), when the sample holder device (10) is in a load application position, a confocal Raman microscopy device (30) having an imaging axis z2 and being arranged for collecting at least one Raman spectrum in the indentation zone (2) of the sample (1), and a calculation device (40) being arranged for calculating at least one strain parameter based on the at least one Raman spectrum, wherein the sample holder device (10), the indenter device (20) and the confocal Raman microscopy device (30) are arranged such that the confocal Raman microscopy device (30) is capable of collecting the at least one Raman spectrum, while the sample holder device (10) is in the load application position, and the indenter device (20) and the confocal Raman microscopy device (30) are arranged such that the load axis z1 of the actuator stage (22) and the imaging axis z2 of the confocal Raman microscopy device (30) coincide. Furthermore, a strain measurement method for measuring mechanical strain in a sample (1) is described.

Classes IPC  ?

• G01N 3/06 - Adaptations particulières des moyens d'indication ou d'enregistrement
• G01N 3/42 - Recherche de la dureté ou de la dureté au rebondissement en effectuant des empreintes sous une charge permanente par des dispositifs de pénétration, p. ex. sphère, pyramide

Abrégé

The present invention relates to a method for preparing α-branched β′-hydroxy carbonyl compounds through enzymatic-catalyzed reductive aldol reaction by reacting α,β-unsaturated carbonyl donors with carbonyl acceptors in the presence of a polypeptide capable of catalyzing reductive aldol reactions and a cofactor, wherein the polypeptide is an enoyl-CoA carboxylase/reductase (Ecr). The replacement of the native CO2 electrophile in enoyl-CoA carboxylases/reductases (Ecrs) by different carbonyl acceptors advantageously creates a new-to-nature biocatalytic route towards α-branched β′-hydroxy carbonyl compounds.

Classes IPC  ?

• C12P 7/40 - Préparation de composés organiques contenant de l'oxygène contenant un groupe carboxyle
• C07C 51/09 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides à partir de lactones ou d'esters d'acides carboxyliques
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase

Abrégé

The present invention relates to a Giant spin Hall effect material based on MxAl100-x, in which M=5d metal (Lu, Hf, Ta, W, Re, Os, Ir, Pt [=5d1-5d9], and x=15-40. Furthermore, the present invention concerns a method of making such Giant spin Hall effect material and a racetrack memory incorporating the Giant spin Hall effect material.

Classes IPC  ?

• H10N 50/85 - Matériaux de la région active
• C22C 21/00 - Alliages à base d'aluminium
• C23C 14/18 - Matériau métallique, bore ou silicium sur d'autres substrats inorganiques
• C23C 14/34 - Pulvérisation cathodique
• C23C 14/35 - Pulvérisation cathodique par application d'un champ magnétique, p. ex. pulvérisation au moyen d'un magnétron
• G11C 11/16 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage électriques ou magnétiques particuliersÉléments d'emmagasinage correspondants utilisant des éléments magnétiques utilisant des éléments dans lesquels l'effet d'emmagasinage est basé sur l'effet de spin
• G11C 19/08 - Mémoires numériques dans lesquelles l'information est déplacée par échelons, p. ex. registres à décalage utilisant des éléments magnétiques utilisant des couches minces dans une structure plane
• H10N 50/01 - Fabrication ou traitement
• H10N 50/10 - Dispositifs magnéto-résistifs
• H10N 50/20 - Dispositifs à courant commandé à polarisation de spin

Abrégé

A connector apparatus 100 for electrically connecting conductor devices (1, 2), in particular in a superconducting condition, comprises a connector receptacle (10) for accommodating a first conductor device (1) and a second conductor device (2) with overlapping conductor sections (1A, 2A) thereof, and a first pivotable pressing clamp (20) having a first clamp shaft (21) and at least one first clamp edge (22) and being arranged for applying a contact pressure on the overlapping conductor sections (1A, 2A) of the first conductor device (1) and the second conductor device (2) so that the overlapping conductor sections (1A, 2A) directly contact each other, wherein the connector receptacle (10) comprises a base portion (11) providing a support for the first and second conductor devices (1, 2) and a bearing portion (12) being arranged adjacent to the base portion (11) for accommodating the first clamp shaft (21) of the first pressing clamp (20), and the first pressing clamp (20) is adapted for a pivoting motion between a clamp condition, wherein the at least one first clamp edge (22) presses the overlapping conductor sections (1A, 2A) against the base portion (11), and a release condition, wherein the at least one first clamp edge (22) of the first pressing clamp (20) releases the overlapping conductor sections (1A, 2A). Furthermore, an electrical conductor arrangement including the connector apparatus (100) and a method of using the connector apparatus (100) are described.

Classes IPC  ?

• H01R 4/28 - Connexions par serrageConnexions par ressort
• H01R 4/50 - Connexions par serrageConnexions par ressort utilisant une came, un coin, un cône ou une bille
• H01R 4/68 - Connexions à ou entre conducteurs supraconducteurs

Abrégé

The present invention relates to a thermally coupled correlated oxide oscillator system comprising at least two correlated oxide oscillators coupled via at least one heating element, which is inter-positioned between at least two of the at least two correlated oxide oscillators. The invention further relates to a logic device comprising a multiplicity of coupled correlated oxide oscillator / heating element cells, wherein each cell has a dimension of 1-heat-n-oscillators.

Classes IPC  ?

• H03B 9/12 - Production d'oscillations par utilisation des effets du temps de transit utilisant des dispositifs à l'état solide, p. ex. dispositifs à effet Gunn

Abrégé

A neutrino detection system and method based on one or more semiconductor Germanium point-contact diodes. These diodes act simultaneously as target for neutrinos or antineutrinos, that scatter off atomic nuclei, and as detectors, that register the ionization energy released in such interactions. Also included are various compact shield configurations that enhance the signal-to-background ratio and allow for a mobile detector operation under many environmental conditions including above ground and close to reactor sites. The neutrino detector can be used, for instance, for reactor operation monitoring, geological-radiochemical surveys and neutrino telecommunication systems.

Classes IPC  ?

• G01T 1/00 - Mesure des rayons X, des rayons gamma, des radiations corpusculaires ou des radiations cosmiques
• G01V 5/06 - Prospection ou détection au moyen de rayonnement ionisant, p. ex. de la radioactivité naturelle ou provoquée spécialement adaptée au carottage pour détecter des minerais à radioactivité naturelle

Abrégé

A magnetic confinement apparatus (100) comprises an evacuable vessel (10) having a torus shape with an inner torus hole (11) and being configured for accommodating a fusion plasma (1), a magnetic coil device (20) being configured for creating a magnetic confinement field (2) in the vessel (10), wherein the magnetic coil device (20) comprises a plurality of axisymmetric coils (21) being configured for creating the magnetic confinement field (2) with an axisymmetric field equilibrium, and a control device (30) being configured for controlling the magnetic coil device (20), wherein the magnetic coil device (20) further comprises at least two quasi-axisymmetric perturbation (QAP) coils (22) being placed outside the vessel (10) within the torus hole (11) of the torus shape and being arranged for subjecting the axisymmetric field equilibrium of the magnetic confinement field (2) to quasisymmetry-preserving perturbations, so that the magnetic confinement field (2) created by the magnetic coil device (20) has quasi-axisymmetry and a magnetic equilibrium of the magnetic confinement field has a quasi-axisymmetric stellarator configuration of the magnetic confinement apparatus (100). Furthermore, a fusion reactor apparatus (200), including the magnetic confinement apparatus (100) and a method of operating the magnetic confinement apparatus are disclosed.

Classes IPC  ?

• G21B 1/05 - Réacteurs de fusion thermonucléaire avec confinement magnétique ou électrique du plasma
• G21B 1/11 - Réacteurs de fusion thermonucléaire Détails

Abrégé

In a method of determining an arrangement of point sources in a sample the point sources are scanned (3) with a probe signal comprising a probe signal intensity. A spatial intensity distribution of the probe signal intensity has a local probe signal intensity minimum that is, in at least one spatial direction, delimited on both sides by probe signal intensity maxima. The local probe signal intensity minimum is positioned at different probe signal minimum positions at distances in the at least one spatial direction. A measurement intensity of a measurement signal coming from the point sources is registered (4) for each of the different probe signal minimum positions. The measurement intensity depends on the probe signal intensity at point source positions of the point sources. The point sources are limited (2) both to a point source number of at least 2, and to such a small spatial area of the sample that a spatial course of the registered measurement intensities over the different probe signal minimum positions has one local measurement signal minimum only. The arrangement of the point sources is determined (5) from the spatial course of the registered measurement intensities over the different probe signal minimum positions utilizing previous knowledge of the arrangement of the point sources.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G01N 21/64 - FluorescencePhosphorescence

Abrégé

The present invention relates to a method for producing aliphatic aldehydes from syngas, a ruthenium catalyst being used in the process.

Classes IPC  ?

• C07C 45/49 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par réaction avec le monoxyde de carbone
• B01J 23/46 - Ruthénium, rhodium, osmium ou iridium
• B01J 31/16 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination

Abrégé

The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly. The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly.

Classes IPC  ?

• A01N 43/82 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec des atomes d'azote et des atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle des cycles à cinq chaînons avec trois hétéro-atomes
• A01N 43/50 - Diazoles-1,3Diazoles-1,3 hydrogénés
• A01N 43/56 - Diazoles-1,2Diazoles-1,2 hydrogénées
• A01N 43/80 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec des atomes d'azote et des atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle des cycles à cinq chaînons avec un atome d'azote et soit un atome d'oxygène, soit un atome de soufre, en positions 1,2
• A01N 43/84 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec des atomes d'azote et des atomes d'oxygène ou de soufre, comme hétéro-atomes du cycle des cycles à six chaînons avec un atome d'azote et soit un atome d'oxygène, soit un atome de soufre, en positions 1,4
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A01P 3/00 - Fongicides
• C07D 231/12 - Composés hétérocycliques contenant des cycles diazole-1, 2 ou diazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• C07D 233/64 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des radicaux hydrocarbonés substitués, liés aux atomes de carbone du cycle, p. ex. histidine
• C07D 249/08 - Triazoles-1, 2, 4Triazoles-1, 2, 4 hydrogénés
• C07D 261/08 - Composés hétérocycliques contenant des cycles oxazole-1, 2 ou oxazole-1, 2 hydrogéné non condensés avec d'autres cycles comportant plusieurs liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• C07D 271/107 - Oxadiazoles-1, 3, 4Oxadiazoles-1, 3, 4 hydrogénés avec deux radicaux aryle ou aryle substitués liés en positions 2 et 5
• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 413/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
• C07D 413/10 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant des cycles aromatiques

Abrégé

The present solution relates to animal behaviour modulation of at least one first animal to be carried out on a device attached to a second animal. The device comprises a memory, at least one sensor, a processor, and a signal generator. The method comprises: storing, in the memory, at least one extracted characteristic feature of training data of at least one monitored physical quantity in at least one degree of freedom in momentum, specific to at least one behaviour of the second animal and/or at least one local environmental condition related to the second animal; monitoring, by the at least one sensor, the at least one monitored physical quantity of the second animal and/or the at least one local environmental condition related to the second animal; determining, by the processor, a type of behaviour of the second animal; and generating, by the signal generator, a warning signal.

Classes IPC  ?

• A01K 27/00 - Laisses ou colliers, p. ex. pour chiens
• A01K 11/00 - Marquage des animaux
• A01M 29/16 - Épouvantails ou dispositifs répulsifs, p. ex. pour oiseaux utilisant des ondes sonores

Abrégé

The invention relates to a method of running a laser system (10) for providing a laser beam (20) capable of heating and/or evaporating and/or sublimating a target (120) located in a reaction chamber (110) of an evaporation system (100), the laser system (10) comprising a laser light source (12) for providing a laser beam (20), and beam adjusting means (40) for adjusting at least the cross section (22) of the laser beam (20), the beam adjusting means (40) comprising along the laser beam (20) a first adjusting section (42), a clipping aperture (70) with a clipping opening (72) and a second adjusting section (44). Further, the invention relates to a laser system (10) for heating and/or evaporating and/or sublimating a target (120) located in a reaction chamber (110) of an evaporation system (100), the laser system (10) comprising a laser light source (12) for providing a laser beam (20), wherein the laser system (10) comprises beam adjusting means (40) comprising along the laser beam (20) a first adjusting section (42), a clipping aperture (70) with a clipping opening (72) and a second adjusting section (44). Additionally, the invention relates to an evaporation system (100) for coating a substrate (126) with evaporated and/or sublimated material of a source (124), comprising a reaction chamber (110) with a reaction volume (112) for arranging the source (124) and the substrate (126), and a substrate (126) laser system (10) for heating the substrate (126) and/or a source (124) laser system (10) for evaporating and/or sublimating material of the source (124).

Classes IPC  ?

• B23K 26/352 - Travail par rayon laser, p. ex. soudage, découpage ou perçage pour le traitement de surface
• B23K 26/06 - Mise en forme du faisceau laser, p. ex. à l’aide de masques ou de foyers multiples
• B23K 26/40 - Enlèvement de matière en tenant compte des propriétés du matériau à enlever
• B23K 26/70 - Opérations ou équipement auxiliaires

Abrégé

A sample receptacle apparatus (100) for arranging a fluid sample (1) in a beam path (2) of measuring radiation (3) in a gas-tight measuring apparatus (200), comprises a sample cell (10) having plane, plate-shaped cell windows (11) with a spacing therebetween, wherein the sample cell (10) is configured for accommodating the sample (1) in the spacing between the cell windows (11), and a cell holder device (20) having a cell support body (21), a first coupling section (22) and a second coupling section (23), wherein the cell support body (21) is configured for accommodating the sample cell (10) and for setting a temperature of the sample cell (10), the first and second coupling sections (22), (23) are configured for a gas-tight coupling of the cell holder device (20) with a closed container device (240) of the measuring apparatus (200), and the cell holder device (20) provides a beam passage (4) along a longitudinal direction z through the first coupling section (22), the cell support body (21) with the sample cell (10), and the second coupling section (23), wherein the sample cell (10) is arranged in the beam passage (4) such that a normal of at least one of the cell windows (11) deviates from the longitudinal direction z of the beam passage (4). Furthermore, a measuring apparatus for a spectroscopic investigation of a sample, including the sample receptacle apparatus (100) and a spectroscopic measuring method are described.

Classes IPC  ?

• G01N 21/03 - Détails de structure des cuvettes
• G01N 21/05 - Cuvettes à circulation de fluides
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/21 - Propriétés affectant la polarisation
• G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
• G01N 21/3577 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de liquides, p. ex. l'eau polluée
• G01N 21/3581 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz
• G01N 21/359 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge proche
• G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge

Abrégé

A method of optical and nucleic acid barcoding of material, the method comprising: providing a first nucleic acid barcode identifiable by sequencing means; providing an optical barcode identifiable by optical means and comprising a second nucleic acid barcode identifiable by said sequencing means; providing material from which nucleic acid molecules are derivable; partitioning the first nucleic acid barcode, the optical barcode and the material within a partition; wherein the material within the partition can be uniquely identified by said optical means using the optical barcode; wherein the first nucleic acid barcode is configured to separately combine with nucleic acid molecules derived from the material and with the second nucleic acid barcode, such that both the nucleic acid molecules derived from the material and the optical barcode encapsulated with the material within the partition can be uniquely identified by said sequencing means using the first nucleic acid barcode, such that the nucleic acid molecules derived from the material identified by said sequencing means can be associated with the material identified by said optical means.

Classes IPC  ?

• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites

Abrégé

The present invention relates to inhibitors of cyclin-dependent kinase 7 (CDK7) and their uses in the treatment of viral infections, in particular infections by DNA-viruses, such as Herpesviridae or Papillomaviridae. The present invention also relates to methods of treatment of viral infections using such inhibitors of cyclin-dependent kinase 7.

Classes IPC  ?

• A61K 31/53 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec trois azote comme seuls hétéro-atomes d'un cycle, p. ex. chlorazanil, mélamine
• A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
• A61P 31/20 - Antiviraux pour le traitement des virus ADN

Abrégé

In a first aspect, the present invention relates to a method of imaging and screening of a compound of interest in a sample based on different types of imaging. Namely, the method comprise first acquiring low or high magnification images of the sample and, after determining a region of interest, superresolution microscopy of the region of interest to screen the compound of interest. In addition, a system for imaging and screening a compound of interest in a sample is described, said system comprising a microscope system combining diffraction limited imaging techniques with superresolution techniques. The system optionally includes a database of properties of known compounds. Finally, a computer program product is provided residing on a computer readable medium, allowing performing the method according to the present invention for controlling a microscope system.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence

Abrégé

Provided is a computer-implemented method for analyzing experimental data. The method comprises receiving a first data set including the experimental data to be analyzed. The method further comprises receiving one or more variation data sets, wherein each variation data set comprises information regarding a variation of experimental observations. Moreover, the method comprises extrapolating the experimental data by applying a variation to the experimental data, wherein the applied variation corresponds to the one or more variations of the experimental observations specified by the information comprised in the one or more variation data sets. The method further comprises generating a synthetic data set based on the extrapolated experimental data, analyzing the synthetic data set, and providing an output based on a result of the analysis of the synthetic data set. The received one or more variation data sets are selected depending on one or more types of noise related to the experimental data to be analyzed.

Classes IPC  ?

• G16B 40/20 - Analyse de données supervisée
• G16B 40/30 - Analyse de données non supervisée

Abrégé

The present invention pertains to the fields of antibody technology, biochemistry, medicine, pharmacology, infection biology, and anti-viral therapy. More specifically, it discloses antibodies, particularly single-domain antibodies, e.g., VHH antibodies that bind an assembled HIV-1 capsid such that the capsid is prevented from entering the permeability barrier of nuclear pore complexes, also called the FG phase. Through the effects of these antibodies, HIV-1 is effectively prevented from entering the cell's nucleus and thus blocked in its life cycle.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps

Abrégé

An interferometric scattering microscopy (iSCAT) apparatus (100) for iSCAT-based imaging a sample under investigation, for obtaining a sample image, comprises an optical imaging system with an illumination device (10), an optical relaying device (20) including a beam splitting device (21), a sample receptacle (30) and a detector device (40). The illumination device (10) includes a laser source device (11) being arranged for creating illumination light (2). The optical relaying device (20) is arranged between the laser device (11) and the sample receptacle (30) for relaying the illumination light (2) to the sample receptacle (30). The beam splitting device (21) is arranged for deflecting a first portion (2A) of the illumination light (2) towards the sample receptacle (30), deflecting a second portion (2B) of the illumination light (2) towards the detector device (40) and for superimposing scattering light (2C) scattered at a sample (1) arranged at the sample receptacle (30) with the second portion (2B) of the illumination light (2). The detector device (40) is arranged for receiving the superimposed scattering light (2C) and second portion (2B) of the illumination light (2) in an image plane of the optical imaging system. A coherence setting device (50) is arranged for targeted setting a point spread function of the optical imaging system in the image plane by applying and controlling a spatial degree of coherence of the illumination light (2) output by the laser source device (11). Furthermore, a method of iSCAT microscopy, including iSCAT-based imaging a sample (1), in particular including bioparticles, like protein particles and/or protein molecules, is described, wherein the iSCAT apparatus (100) is employed.

Classes IPC  ?

• G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
• G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse
• G01N 15/1433 - Traitement du signal utilisant la reconnaissance d’image
• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G02B 21/00 - Microscopes
• G01N 15/10 - Recherche de particules individuelles
• G01N 15/1434 - Dispositions optiques

Abrégé

In a first aspect, the invention relates to a method for imaging and screening a component of interest in a sample based on different types of imaging. In particular, the method comprises first acquiring low or high magnification images of the sample and, after determining the region of interest, MINFLUX and/or MINSTED superresolution microscopy of the region of interest to screen the compound of interest. A system is further described for imaging and screening a compound of interest in a sample, the system comprising a microscope system combining diffraction-limited imaging techniques with at least one of MINFLUX or MINSTED superresolution techniques. The system optionally comprises a database of properties of known compounds. Finally, a computer program product resided on a computer-readable medium is provided to enable the method of the invention to be carried out for controlling a microscope system.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.

Classes IPC  ?

• C09B 57/00 - Autres colorants synthétiques de structure connue
• C09B 6/00 - Colorants anthracéniques non prévus par les groupes ci-dessus
• C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes

Abrégé

The present invention relates to a method for producing a fat composition comprising the following steps: a) providing water, b) adding lipase, c) adding triglyceride, d) incubate the mixture obtained in step c), e) inactivation of lipase, f) separation of the aqueous phase from the fatty phase of the mixture obtained in step e) in a separating funnel, g) optional heating of the separated fatty phase to remove the remaining aqueous phase, wherein the method is performed without the addition of papain. In addition, the present invention relates to a fat composition obtained by the method according to the invention and a food composition comprising the fat composition according to the invention, as well as method for producing the food composition.

Classes IPC  ?

• A23L 13/60 - Produits à base de viande hachée ou émulsifiée, p. ex. saucissesViande reconstituée à partir de viande hachée
• A23L 33/115 - Acides gras ou leurs dérivésGraisses ou huiles
• C11B 1/00 - Production des graisses ou huiles à partir de matières premières
• C11C 3/10 - Graisses, huiles ou acides gras obtenus par transformation chimique des graisses, huiles ou acides gras, p. ex. ozonolyse par estérification des graisses ou des huiles par interestérification
• C12P 7/64 - GraissesHuilesCires de type esterAcides gras supérieurs, c.-à-d. ayant une chaîne continue d'au moins sept atomes de carbone liée à un groupe carboxyleHuiles ou graisses oxydées

Abrégé

The invention discloses a method that uses a measured density map of a molecule and related molecular model to improve the resolution of the molecule structure using fitness scores between conformers of models of the unresolved parts of the molecule and the density map.

Classes IPC  ?

• G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p. ex. relations structurelles ou fonctionnelles ou alignement de structures
• G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase

Abrégé

The present invention relates to methods for modifying the activity of transcription factors by altering the periodicity and/or number of the aromatic amino acid residues in their intrinsically disordered regions (IDRs) thereby obtaining altered transcription factors having modified, e.g., increased and/or reduced transcriptional activity. Further, the present invention relates to novel altered transcription factors and nucleic acid molecules encoding those altered transcription factors. Furthermore, applications for the altered transcription factors, e.g., in cell programming methods, are disclosed.

Classes IPC  ?

• C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 38/00 - Préparations médicinales contenant des peptides
• C12N 15/79 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes

Abrégé

The present invention relates to a method for increasing the photosynthesis of a plant, plant part, or plant cell by increasing the expression of the squamosa promoter binding protein-like gene 9 (SPL9 gene) in the plant, plant part, or plant cell and/or by increasing the level of the squamosa promoter binding protein-like protein 9 (SPL9 protein) in the plant, plant part, or plant cell.

Classes IPC  ?

• C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
• C12N 9/22 - Ribonucléases
• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

A potential measuring apparatus (100) for determining a physicochemical surface property based on a surface potential at a sample surface (2) of a solid sample (1), like the surface potential and/or a zeta potential of the sample surface (2), comprises a sample support (10) for accommodating the sample (1), a drop supply device (20) for placing a liquid probe drop (3) on the sample surface (2), a drop movement device (30) for providing a sliding movement of the probe drop (3) along a predetermined sliding path (4) on the sample surface (2), an electrode measuring device (40) for sensing an electrical quantity including at least one of a drop voltage and a drop charge of the probe drop (3) after passing the sliding path (4), wherein the electrode measuring device (40) includes a probe electrode (41) arranged at a downstream end of the sliding path 4 and a measuring circuit (42) coupled with the probe electrode (41), and a calculation device (50) for determining the physicochemical surface property based on the electrical quantity. Furthermore, a potential measuring method for determining a physicochemical surface property based on a surface potential at a sample surface (2) of a solid sample (1) is described.

Classes IPC  ?

• G01N 13/02 - Recherche de la tension superficielle des liquides
• G01N 27/60 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les variables électrostatiques
• G01R 31/26 - Test de dispositifs individuels à semi-conducteurs

Abrégé

Provided are a method and a device for characterizing a resonator element, a method and a device for providing an optical frequency reference, a LIDAR system and a gas sensing system. The method includes coupling a laser light into the resonator element, the resonator element having multiple carrier resonances for the carrier frequency of the laser light.

Classes IPC  ?

• G01M 11/02 - Test des propriétés optiques

Abrégé

Method for automatic focusing and astigmatism correction for a specific microscope setup, in particular an electron microscope, the microscope being at least adjustable in microscope parameters a working distance, a stigmator in a x-direction and a stigmator in a y-direction, the method comprising the steps: a) capturing a first image of a sample with a first working distance perturbation and capturing a second image of the sample with a second working distance perturbation around a current working distance and current stigmator settings; b) selecting n subareas of the first image and n subareas of the second image, n≥1, wherein an i-th subarea of the first image and an i-th subarea of the second image form an i-th input patch pair, 1≤i≤n; c) processing each i-th input patch pair and receiving an i-th correction term comprising a correction to the current working distance, stigmator in x-direction and stigmator in y-direction; d) receiving an output correction term as a function of all the correction terms; e) adjusting the current working distance and stigmator settings by applying the output correction term to the current working distance and stigmator settings.

Classes IPC  ?

• H01J 37/21 - Moyens pour la mise au point
• H01J 37/153 - Dispositions électronoptiques ou ionoptiques pour la correction de défauts d'images, p. ex. stigmateurs

Abrégé

The invention relates to a source arrangement (10) for a TLE system (100) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by a laser beam (112), comprising a support (20) carrying said source element. Further, the invention relates to a TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14). In addition, the invention relates to a method for using a TLE system (100), the TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14).

Classes IPC  ?

• C23C 14/28 - Évaporation sous vide par énergie éléctromagnétique ou par rayonnement corpusculaire

Abrégé

The present disclosure relates to compounds that bind to the kelch domain-containing protein 2 (KLHDC2) E3 ligase active site and heterobifunctional targeted protein degraders comprising the compounds. Methods of using these degraders in the treatment of cancer is also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Classes IPC  ?

• C07D 495/14 - Systèmes condensés en ortho
• A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
• A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
• A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
• C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
• C07D 471/04 - Systèmes condensés en ortho
• C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou

Abrégé

Connectomes of human cortical gray matter require high-contrast homogeneously stained samples sized at least 2-3 mm on a side, and a whole-mouse brain connectome requires samples sized at least 5-10 mm on a side. Here, en-bloc staining and postprocessing protocols are reported, including dehydrating and embedding of neuronal samples, for dense neuronal circuit reconstruction and other applications.

Classes IPC  ?

• G01N 1/30 - TeintureImprégnation
• G01N 23/2251 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en mesurant l'émission secondaire de matériaux en utilisant des microsondes électroniques ou ioniques en utilisant des faisceaux d’électrons incidents, p. ex. la microscopie électronique à balayage [SEM]