The invention relates to a valve comprising a body provided with at least three ports and a plug (20). The plug comprises a tubular barrel (21), the outer surface (22C) of a tubular wall (22) of which is complementary to an internal volume of the body in such a way that the barrel is sealingly arranged therein while being capable of being rotated about a central axis (Z21) of the barrel. The plug comprises a channel (25) connecting the ports according to the angular position of the barrel. The channel passes through the tubular wall, from its outer surface to its inner surface (22D), and extends inside the barrel by joining together at least two distinct openings each located in the same portion of the tubular wall extending over an angle of no more than 180°. The tubular wall has, on either axial side of the channel, a greater internal thickness in this portion than in the rest of the tubular wall.
The invention relates to a composition for use in a method of embolotherapy and/or in the preparation of therapeutic depots for use by injection comprising: a) a tri-arm copolymer of hydroxyethyl methacrylate (HEMA), 3-hydroxypropyl methacrylate (HPMA) and N-isopropyl methacrylamide (NIPAAM); and b) a contrast agent, preferably iodinated. The invention also relates to a process for preparing an embolic composition or a therapeutic depot for use by injection comprising combining a tri-arm copolymer as described above, optionally in the form of an aqueous composition, with a contrast agent and a therapeutic product, and to a kit for the preparation of said embolic composition or therapeutic depot.
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
A diaphragm (1) for a non-return valve (2) in the field of devices for medical use allowing the injection of liquids into the human body, comprising at least two opposite faces connected by a first rough axial surface (9), the diaphragm (1) comprising at least: - A central portion (3) comprising a first rough radial central surface (4); - An intermediate annular portion (5) around the central portion (3), the intermediate annular portion (5) comprising a first smooth radial surface (6), the first smooth radial surface (6) surrounding the rough radial central surface (4); - A peripheral annular portion (7) around the second, intermediate portion (5), the peripheral annular portion (7) comprising a first rough peripheral radial surface (8) and the first rough axial surface (9), the first rough peripheral radial surface (8) surrounding the first smooth radial surface (6); the first rough radial central surface (4), the first smooth radial surface (6) and the first rough peripheral radial surface (8) extending radially and being configured to be on a same face of the diaphragm (1).
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products; medical and veterinary
preparations; diagnostic products for medical use;
diagnostic reagents and contrast media for medical use in
radiology; contrast media for medical magnetic-resonance
imaging; sanitary products for medicine; disinfectants for
medical or sanitary use (other than soaps). Software; artificial intelligence software; medical
management software; software used in radiology centers for
collection and management of data relating to patient
treatment; artificial intelligence software for controlling
and tracking the quantities of ionizing radiation
administered to patients; artificial intelligence software
for analysis; artificial intelligence software for health
care; interactive software based on artificial intelligence;
artificial intelligence software and machine learning
software; artificial intelligence software for monitoring;
data processing apparatus with artificial intelligence and
intercommunication apparatus with artificial intelligence. Surgical, medical, dental and veterinary apparatus and
instruments; Medical devices for use with pharmaceutical or
diagnostic products; contrast media injectors used in
medical imaging procedures; contrast media injectors with
artificial intelligence used in the framework of carrying
out medical services. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; exchange of electronic voice, audio and video
content, data, graphics and text that can be accessed via
computer telecommunications networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and information
by computer and electronic communication means; transfer of
information and data via on-line services and the Internet;
satellite transmission; communication by computer terminals;
transmission services for digital data; providing access to
a computer network; providing access to information via data
networks; provision of access to information in computer
networks. Scientific studies and research relating to medical imaging;
advice and studies with respect to scientific research in
the fields of radiology and magnetic resonance imaging;
installation of software, maintenance of software, updating
of software and rental of software used for medical purposes
in the field of radiology and magnetic resonance imaging;
provision of artificial-intelligence computer programs on
data networks; provision of computer programs in the field
of artificial intelligence on data networks; artificial
intelligence platforms as Software as a Service [SaaS]. Medical services; medical analysis services; radiological,
magnetic resonance imaging and medical examinations;
information services relating to health, healthcare
services.
An injection device for injecting a medical liquid, comprising a piston arranged within an inner space delimiting an upper space and a lower space, an evacuation path, said evacuation path traversing the piston the lower space to the upper space of the inner space, a selector between a lower portion and an intermediate portion of the evacuation path, configured for selectively allowing the gas to go through and preventing the medical liquid from going through said selector, a purge valve between the intermediate portion of the evacuation path and an upper portion of the evacuation path and configured for moving between a blocking and a passing configuration which requires an overpressure in the intermediate portion caused by the piston travelling towards the lower end of the body.
An injection device for injecting into a medical tubing a medical liquid from a medical liquid container, said injection device comprising a body, a piston (6) arranged in the body for travelling along the longitudinal direction, said piston (6), an evacuation path traversing the piston (6), and a float (24) configured for floating on the medical liquid and configured for travelling within a cavity (36) along the longitudinal direction between a blocking configuration in which an obturating part (24a) of the float (24) obturates the passage (38) of the evacuation path, thereby closing the evacuation path, and an open configuration in which the obturating part 24a of the float (24) is spaced apart from the passage (38), thereby letting open the evacuation path, wherein the float (24) has a metacenter (M) which is spaced apart from the top of the obturating part (24a) by a distance less than one third of the height of the float (24).
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products; medical and veterinary
preparations; diagnostic products for medical use;
diagnostic reagents and contrast media for medical use in
radiology; contrast media for medical magnetic-resonance
imaging; sanitary products for medicine; disinfectants for
medical or sanitary use (other than soaps). Software; artificial intelligence software; medical
management software; software used in radiology centers for
collection and management of data relating to patient
treatment; artificial intelligence software for controlling
and tracking the quantities of ionizing radiation
administered to patients; artificial intelligence software
for analysis; artificial intelligence software for health
care; interactive software based on artificial intelligence;
artificial intelligence software and machine learning
software; artificial intelligence software for monitoring;
data processing apparatus with artificial intelligence and
intercommunication apparatus with artificial intelligence. Surgical, medical, dental and veterinary apparatus and
instruments; Medical devices for use with pharmaceutical or
diagnostic products; contrast media injectors used in
medical imaging procedures; contrast media injectors with
artificial intelligence used in the framework of carrying
out medical services. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; exchange of electronic voice, audio and video
content, data, graphics and text that can be accessed via
computer telecommunications networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and information
by computer and electronic communication means; transfer of
information and data via on-line services and the Internet;
satellite transmission; communication by computer terminals;
transmission services for digital data; providing access to
a computer network; providing access to information via data
networks; provision of access to information in computer
networks. Scientific studies and research relating to medical imaging;
advice and studies with respect to scientific research in
the fields of radiology and magnetic resonance imaging;
installation of software, maintenance of software, updating
of software and rental of software used for medical purposes
in the field of radiology and magnetic resonance imaging;
provision of artificial-intelligence computer programs on
data networks; provision of computer programs in the field
of artificial intelligence on data networks; artificial
intelligence platforms as Software as a Service [SaaS]. Medical services; medical analysis services; radiological,
magnetic resonance imaging and medical examinations;
information services relating to health, healthcare
services.
A vial holding system (1) for a medical fluid injection assembly, the vial holding system (1) comprising: a toothed rack (6) extending in a first longitudinal direction (Z), a cradle (2) comprising a frame (5) configured to receive and hold a vial (4) of medical fluid and a support (10) configured to support the cradle (2) on the toothed rack (6), wherein the support (10) is provided with teeth (11) configured to engage with the toothed rack (6), and is configured to urge the teeth (11) in an engagement direction (X) into engagement with the toothed rack (6), a portion (10a) of the support (10) being moveable with respect to the frame (5) of the cradle, wherein the system further comprises an actuator (30) configured to selectively cause the support (10) to be moved and the teeth (11) of the support to disengage from the toothed rack (6).
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Yang, Sisi
Bône, Alexandre
Glaunès, Joan Alexis
Abrégé
The invention relates to a method implemented by computer means for quantifying irregularities of a surface of an anatomical region of a patient in at least one medical image, said method comprising the following steps: (a) obtaining at least one medical image representing said anatomical region, (b) segmenting said anatomical region or at least a part of said anatomical region, (c) detecting the actual contour of said anatomical region from said segmented anatomical region, (d) computing a smoothed contour of said anatomical region based on said actual contour, (e) calculating a score based on the distance between the actual contour and the smoothed contour.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products; medical and veterinary preparations; diagnostic products for medical use; diagnostic reagents and contrast media for medical use in radiology; contrast media for medical magnetic-resonance imaging; sanitary products for medicine; disinfectants for medical or sanitary use (other than soaps). Software; artificial intelligence software; medical management software; software used in radiology centers for collection and management of data relating to patient treatment; artificial intelligence software for controlling and tracking the quantities of ionizing radiation administered to patients; artificial intelligence software for analysis; artificial intelligence software for health care; interactive software based on artificial intelligence; artificial intelligence software and machine learning software; artificial intelligence software for monitoring; data processing apparatus with artificial intelligence and intercommunication apparatus with artificial intelligence. Surgical, medical, dental and veterinary apparatus and instruments; Medical devices for use with pharmaceutical or diagnostic products; contrast media injectors used in medical imaging procedures; contrast media injectors with artificial intelligence used in the framework of carrying out medical services. Data transmission and telecommunication services; electronic exchange of data stored in databases accessible via telecommunication networks; secure electronic messaging services; exchange of electronic voice, audio and video content, data, graphics and text that can be accessed via computer telecommunications networks; services for the transmission of data, particularly, for the transmission of computerized documents; transmission of data and information by computer and electronic communication means; transfer of information and data via on-line services and the Internet; satellite transmission; communication by computer terminals; transmission services for digital data; providing access to a computer network; providing access to information via data networks; provision of access to information in computer networks. Scientific studies and research relating to medical imaging; advice and studies with respect to scientific research in the fields of radiology and magnetic resonance imaging; installation of software, maintenance of software, updating of software and rental of software used for medical purposes in the field of radiology and magnetic resonance imaging; provision of artificial-intelligence computer programs on data networks; provision of computer programs in the field of artificial intelligence on data networks; artificial intelligence platforms as Software as a Service [SaaS]. Medical services; medical analysis services; radiological, magnetic resonance imaging and medical examinations; information services relating to health, healthcare services.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
38 - Services de télécommunications
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products; medical and veterinary preparations; diagnostic products for medical use; diagnostic reagents and contrast media for medical use in radiology; contrast media for medical magnetic-resonance imaging; sanitary products for medicine; disinfectants for medical or sanitary use (other than soaps). Data transmission and telecommunication services; electronic exchange of data stored in databases accessible via telecommunication networks; secure electronic messaging services; exchange of electronic voice, audio and video content, data, graphics and text that can be accessed via computer telecommunications networks; services for the transmission of data, particularly, for the transmission of computerized documents; transmission of data and information by computer and electronic communication means; transfer of information and data via on-line services and the Internet; satellite transmission; communication by computer terminals; transmission services for digital data; providing access to a computer network; providing access to information via data networks; provision of access to information in computer networks. Software; artificial intelligence software; medical management software; software used in radiology centers for collection and management of data relating to patient treatment; artificial intelligence software for controlling and tracking the quantities of ionizing radiation administered to patients; artificial intelligence software for analysis; artificial intelligence software for health care; interactive software based on artificial intelligence; artificial intelligence software and machine learning software; artificial intelligence software for monitoring; data processing apparatus with artificial intelligence and intercommunication apparatus with artificial intelligence. Surgical, medical, dental and veterinary apparatus and instruments; Medical devices for use with pharmaceutical or diagnostic products; contrast media injectors used in medical imaging procedures; contrast media injectors with artificial intelligence used in the framework of carrying out medical services. Scientific studies and research relating to medical imaging; advice and studies with respect to scientific research in the fields of radiology and magnetic resonance imaging; installation of software, maintenance of software, updating of software and rental of software used for medical purposes in the field of radiology and magnetic resonance imaging; provision of artificial-intelligence computer programs on data networks; provision of computer programs in the field of artificial intelligence on data networks; artificial intelligence platforms as Software as a Service [SaaS]. Medical services; medical analysis services; radiological, magnetic resonance imaging and medical examinations; information services relating to health, healthcare services.
13.
METHOD FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE AND A CONTRAST IMAGE RESPECTIVELY DEPICTING A BODY PART PRIOR TO AND AFTER AN INJECTION OF A FIRST DOSE OF CONTRAST AGENT
The present invention relates to method for medical imaging, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining at least one candidate pre-contrast image and a candidate contrast image respectively depicting a body part prior to and after an injection of a first dose of contrast agent, wherein said first dose is higher than a predetermined low dose, the predetermined reduced dose being lower than a predetermined standard dose; a convolutional neural network, CNN, being trained to reconstruct, from at least a pre-contrast input image and a low dose contrast input image respectively depicting a body part prior to and after an injection of said low dose of contrast agent, a standard dose contrast image depicting said body part after an injection of said standard dose of contrast agent; (b) Simulating an injection of a second dose of contrast agent which is higher than the standard dose, wherein said simulating comprises generating a synthetic contrast image by applying the CNN to the at least one candidate pre-contrast image and the candidate contrast image.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
14.
METHOD FOR DETERMINING A PROBABILITY OF THE PRESENCE OF AT LEAST ONE CANDIDATE LESION IN AT LEAST ONE MEDICAL IMAGE
Method for determining a probability of the presence of at least one candidate lesion in at least one medical image The invention relates to a method implemented by computer means for determining a probability of the presence of at least one candidate lesion in at least one medical image, said method including an inference phase comprising the following steps: - segmenting said at least one candidate lesion on said image using a trained segmentation model, to obtain at least one segmented region representing the location of the at least one candidate lesion in the image, said at least one segmented region being a connected component and being associated to a probability that said connected component is a lesion, - detecting said at least one candidate lesion on said image using a trained detection model, to obtain at least one bounding box representing the location of the candidate lesion in said image, said at least one bounding box being associated to a probability that said bounding box is a lesion, - matching the at least one connected component obtained by the segmentation model to a corresponding bounding box obtained by the detection model, - predicting the probability that said at least one connected component obtained by the segmentation model is a lesion, based on both the probability obtained by the segmentation model for the corresponding connected component and the probability obtained by the detection model of the bounding box that match with said corresponding connected component.
An injection device (1) for delivering a medical fluid, comprising an interface module (4) configured to receive a syringe (6), the interface module (4) defining a reception space (40) adapted to receive a flange (12a) in the outer periphery of a barrel (10) of the syringe (6), a drive member (8) configured to couple a piston of the syringe, and to translate along a longitudinal axis (X). The interface module (4) comprises a lateral opening (46) defined between two supporting members (50) of the interface module (4) and extending radially in a first radial direction from the longitudinal axis (X), said lateral opening (46) adapted for a radial translation of the syringe (6) in the first radial direction to a loaded position in which the flange (12a) of the syringe (6) is received in the reception space and the barrel (10) of the syringe (6) extends along the longitudinal axis (X).
A connection system for connecting a first medical line (101) to a second medical line (201) leading to an injector, comprising a first connector (100) coupled to the first medical line and a second connector (200) coupled to the second medical line, wherein the second connector (200) comprises a line path (210) for the second medical line (201), comprising an exposure section (220) for exposing the second medical line, and the connection system comprises a docking station (300) configured to receive the second connector (200) in a reception space so that the first connector (100) can be engaged with the second connector (200) by moving the first connector (100) in an engagement direction into the second connector (200) received in the reception space (304), and wherein the docking station (300) comprises an air sensor faced by the exposure section (220) when the second connector (200) is received into the reception space (304).
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 39/00 - Tubes, raccords ou accouplements pour tubes, soupapes, voies d'accès ou similaires, spécialement adaptés pour un usage médical
17.
METHOD FOR DETECTING AT LEAST ONE LESION OF A PANCREAS OF A PATIENT IN AT LEAST ONE MEDICAL IMAGE
The invention relates to a method implemented by computer means for Method for detecting at least one lesion of a pancreas of a patient in at least one medical image, for example portal venous computed tomography (CT) scans. A segmentation network is trained in a 5-fold cross-validation manner. Then, outputs of this network are postprocessed to extract imaging features: a normalized lesion risk, the predicted lesion diameter, and the MPD diameter in the head, body, and tail of the pancreas. A logistic regression model is calibrated to predict lesion presence based on said features.
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
The present invention relates to new macrocyclic ligands substituted with at least one picolinate group, to the radioactive complexes thereof and to the uses thereof in medical imaging and/or in therapy, in particular in interventional radiology. The present invention also relates to a new process for preparing ligands according to the invention, and also to the preparation intermediates thereof.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
Medical devices for use with pharmaceutical and diagnostic products for administering pharmaceuticals; set of medical devices for the preparation and injection of pharmaceutical solutions
21.
METHODS FOR TRAINING A PREDICTION MODEL, OR FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE DEPICTING A BODY PART PRIOR TO AN INJECTION OF CONTRAST AGENT USING SAID PREDICTION MODEL
The present invention relates to a method for processing at least a pre-contrast image depicting a body part prior to an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining said pre-contrast image; (b) Determining, by application of a prediction model to said pre-contrast image candidate value(s) of at least one injection parameter of said injection of contrast agent, such that the sequence of said pre-contrast image and at least a contrast image depicting said body part during injection of contrast agent in accordance with the determined candidate value(s) of said injection parameter(s) minimizes a radiation dose.
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
METHODS FOR TRAINING A TOMOSYNTHESIS RECONSTRUCTION MODEL, OR FOR GENERATING AT LEAST ONE CONTRAST TOMOGRAM DEPICTING A TARGET BODY PART DURING AN INJECTION OF CONTRAST AGENT
The present invention relates to a method for generating at least one contrast tomogram depicting a target body part during an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining a pre-contrast tomogram of said target body part prior to the injection of contrast agent, and raw projection data acquired over a limited rotation angle span during the injection of contrast agent; (b) Segmenting said target body part on the pre-contrast tomogram; (c) Generating the contrast tomogram, by application of a tomosynthesis reconstruction model to said segmented pre-contrast tomogram and the obtained raw projection data.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Vétil, Rebeca
Abi-Nader, Clément
Bône, Alexandre
Rohé, Marc-Michel
Gori, Pietro
Bloch, Isabelle
Abrégé
The invention relates to a method implemented by computer means for characterizing at least one organ of a patient in at least one medical image, said method comprising the following iterative steps of: segmenting (6) said organ in at least one image (7) representing a healthy organ, so as to obtain at least one segmentation mask (8) of said healthy organ, generating additional segmentation masks of said healthy organ, using at least one data augmentation method (9) on the basis of the segmentation mask obtained in step (a), said data augmentation method (9) being a shape-preserving method, training an autoencoder (10) with the segmentation mask obtained in step (a) and the additional segmentation masks obtained in step (b) to encode the shape of said organ in a latent space (11 ).
The present invention relates to a method for processing an inputted perfusion sequence, by means of a convolutional neural network, CNN, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (b) extracting, using an encoder branch of the CNN, a plurality of initial n+1-dimensional features maps representative of the inputted perfusion sequence at different scales, n≥3, said CNN further comprising a decoder branch and skip connections between the encoder branch and the decoder branch, each skip connection projecting the initial n+1-dimensional features maps into initial n-dimensional feature maps; (c) generating, using said decoder branch of the CNN, a plurality of enriched n-dimensional feature maps also representative of representative of the inputted perfusion sequence at different scales, each enriched n-dimensional feature map incorporating the information from the initial n-dimensional feature maps of smaller or equal scale; (d) generating at least one quantitative map of the inputted perfusion sequence from the largest-scale enriched n-dimensional feature maps.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
25.
EMBOLIZING EMULSION FOR TREATMENT OF INFLAMMATORY HYPERVASCULARIZATION ASSOCIATED WITH MUSCULOSKELETAL DISORDERS
The present invention relates to an embolizing emulsion comprising iodinated oil and an aqueous phase comprising a water-soluble contrast agent for use in the treatment of inflammatory hypervascularization associated with a musculoskeletal disorder.
A61K 31/201 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p. ex. acides oléique ou linoléique
METHODS FOR TRAINING AT LEAST A PREDICTION MODEL, OR FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE DEPICTING A BODY PART PRIOR TO AN INJECTION OF CONTRAST AGENT USING SAID PREDICTION MODEL
The present invention relates to a method for processing at least a pre-contrast image depicting a body part prior to an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining said pre-contrast image; (b) Determining candidate value(s) of at least one injection parameter of said injection of contrast agent by application of a prediction model to said pre-contrast image, such that a theoretical contrast image depicting said body part during injection of contrast agent in accordance with the determined candidate value(s) of said injection parameter(s) is expected to present a target quality level.
The invention relates to a method implemented by computer means for a method implemented by computer means for classifying at least one medical image of at least an organ of a patient, said method including an inference phase comprising the following iterative steps: (a) segmenting at least one area of interest of said image, said area representing at least one an area of said organ, (b) extracting at least one feature from said area of interest, (c) classifying said area of interest on the basis of said feature, (d) outputting said class of said area of interest.
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/70 - Étiquetage du contenu de scène, p. ex. en tirant des représentations syntaxiques ou sémantiques
G06V 10/46 - Descripteurs pour la forme, descripteurs liés au contour ou aux points, p. ex. transformation de caractéristiques visuelles invariante à l’échelle [SIFT] ou sacs de mots [BoW]Caractéristiques régionales saillantes
29.
RADIOPAQUE MONOMER AND EMBOLISATION MICROSPHERES COMPRISING SAME
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (France)
UNIVERSITE PARIS-SACLAY (France)
Inventeur(s)
Moine, Laurence
Francois, Baptiste
Fougere, Olivier
Louguet, Stéphanie
Abrégé
The present invention relates to a compound of the following formula (A) mainly for use as a radiopaque monomer: The invention further relates to radiopaque embolisation microspheres based at least on: 20% to 90% hydrophilic monomer; 5% to 50% compound of formula (A); 1% to 15% non-biodegradable hydrophilic crosslinking monomer; and - 0.1% to 10% transfer agent. The invention also relates to a pharmaceutical composition comprising at least one embolisation microsphere according to the invention, in association with a pharmaceutically acceptable carrier, advantageously for parenteral administration. The invention further relates to a kit comprising a pharmaceutical composition according to the invention in association with a pharmaceutically acceptable carrier for parenteral administration, and to an injection means.
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
C08F 220/28 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle ne contenant pas de cycles aromatiques dans la partie alcool
An injection device (1) for injecting a medical liquid, comprising: —a piston (6) arranged within an inner space (4) delimiting an upper space (4b) and a lower space (4a), —an evacuation path, said evacuation path traversing the piston (6) the lower space (4a) to the upper space (4b) of the inner space, —a selector (24) between a lower portion (17a) and an intermediate portion (17b) of the evacuation path, configured for selectively allowing the gas to go through and preventing the medical liquid from going through said selector (24, 50, 60), —a purge valve (22) between between a blocking and a passing configuration which requires an overpressure in the intermediate portion (17b) caused by the piston (6) travelling towards the lower end of the body (2).
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
involving:
i) decomplexation of the complex of formula (II):
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
involving:
i) decomplexation of the complex of formula (II):
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
involving:
i) decomplexation of the complex of formula (II):
constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
involving:
i) decomplexation of the complex of formula (II):
constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
ii) removing the gadolinium salt formed in step i), for example by filtration, and
ii) recovering the free macrocyclic ligand of formula (L).
The present invention relates to a process for preparing the macrocyclic ligand of formula (L) below:
involving:
i) decomplexation of the complex of formula (II):
constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
ii) removing the gadolinium salt formed in step i), for example by filtration, and
ii) recovering the free macrocyclic ligand of formula (L).
The present invention also relates to a composition comprising the diastereoisomerically enriched complex of formula (II) and the macrocyclic ligand of formula (L).
The invention relates to a valve comprising a body provided with at least three ports and a plug (20). The plug comprises a tubular barrel (21), the outer surface (22C) of a tubular wall (22) of which is complementary to an internal volume of the body in such a way that the barrel is sealingly arranged therein while being capable of being rotated about a central axis (Z21) of the barrel. The plug comprises a channel (25) connecting the ports according to the angular position of the barrel. The channel passes through the tubular wall, from its outer surface to its inner surface (22D), and extends inside the barrel by joining together at least two distinct openings each located in the same portion of the tubular wall extending over an angle of no more than 180°. The tubular wall has, on either axial side of the channel, a greater internal thickness in this portion than in the rest of the tubular wall.
F16K 5/04 - Robinets à boisseau consistant seulement en un dispositif obturateur dont au moins une des faces d'obturation a la forme d'une surface de solide de révolution plus ou moins complète, le mouvement d'ouverture et de fermeture étant essentiellement rotatif dont les boisseaux sont à surface cylindriqueLeurs garnitures d'étanchéité
F16K 11/085 - Soupapes ou clapets à voies multiples, p. ex. clapets mélangeursRaccords de tuyauteries comportant de tels clapets ou soupapesAménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont toutes les faces d'obturation se déplacent comme un tout comportant uniquement des robinets à boisseau à noix cylindrique
33.
MULTI-PART ADAPTER ASSEMBLY FOR BULK MEDICAL FLUID CONTAINER
A medical container assembly is disclosed having an adapter assembly that fluidly connects with a medical container having a volume of medical fluid to accommodate multiple injections. The adapter assembly includes a spike assembly (300) that fluidly connects with the medical container, along with a spike interface cover (200) that detachably connects with the spike assembly (300). Features are incorporated by the spike assembly (300) to reduce the potential that the spike assembly (300) will be used with multiple medical containers. The spike interface cover (200) is detachably connected with the spike assembly (300) and includes features that allows the spike interface cover (200) to be used with a spike assembly (300) installed on one container, and to thereafter allow this same spike interface cover (200) to be used with another spike assembly (300) installed on another container.
An injection device for injecting into a medical tubing a medical liquid from a medical liquid container, said injection device comprising a body, a piston (6) arranged in the body for travelling along the longitudinal direction, said piston (6), an evacuation path traversing the piston (6), and a float (24) configured for floating on the medical liquid and configured for travelling within a cavity (36) along the longitudinal direction between a blocking configuration in which an obturating part (24a) of the float (24) obturates the passage (38) of the evacuation path, thereby closing the evacuation path, and an open configuration in which the obturating part 24a of the float (24) is spaced apart from the passage (38), thereby letting open the evacuation path, wherein the float (24) has a metacenter (M) which is spaced apart from the top of the obturating part (24a) by a distance less than one third of the height of the float (24).
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 39/24 - Soupapes de retenue ou soupapes anti-retour
An injection device (1) for injecting a medical liquid, comprising: • - a piston (6) arranged within an inner space (4) delimiting an upper space (4b) and a lower space (4a), • - an evacuation path, said evacuation path traversing the piston (6) the lower space (4a) to the upper space (4b) of the inner space, • - a selector (24) between a lower portion (17a) and an intermediate portion (17b) of the evacuation path, configured for selectively allowing the gas to go through and preventing the medical liquid from going through said selector (24, 50, ), • - a purge valve (22) between the intermediate portion (17b) of the evacuation path and an upper portion (17c) of the evacuation path and configured for moving between a blocking and a passing configuration which requires an overpressure in the intermediate portion (17b) caused by the piston (6) travelling towards the lower end of the body (2).
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
A61M 5/36 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras avec des moyens pour éliminer l'air ou pour empêcher l'injection ou l'introduction d'air dans le corps
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 39/24 - Soupapes de retenue ou soupapes anti-retour
36.
Method for synthesizing 2-bromoglutaric acid diesters
The present invention relates to a process for preparing the 2-bromoglutaric acid diester of formula (I) below:
comprising the formation of the 2-hydroxyglutaric acid diester of formula (II)
by reaction of butyrolactone acid of formula (BA)
with the alcohol of formula ROH, in the presence of an acid such as sulfuric acid; and bromination of the 2-hydroxyglutaric acid diester of formula (II), by sparging with gaseous hydrobromic acid.
The present invention also relates to a 2-bromoglutaric acid diester of formula (I), having a degree of purity determined by HPLC analysis of greater than or equal to 90%.
C07C 69/63 - Esters contenant des atomes d'halogène d'acides saturés
C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
C07C 67/307 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par introduction d'atomes d'halogènePréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par substitution d'atomes d'halogène par des atomes d'autres halogènes
C07C 67/54 - SéparationPurificationStabilisationEmploi d'additifs par modification de l'état physique, p. ex. par cristallisation par distillation
C07D 307/33 - Atomes d'oxygène en position 2, l'atome d'oxygène étant sous la forme céto ou énol non substituée
37.
NON DEGRADABLE RADIO-OPAQUE EMBOLISATION MICROSPHERE
The invention relates to a polymer comprising a crosslinked matrix, the matrix being based on at least: a) 20 to 90% hydrophilic monomer; b) 5 to 50% radio-opaque halogenated monomer; c) 1 to 15% non-biodegradable hydrophilic crosslinking agent; and d) 0.1 to 10% transfer agent chosen among the alkyl halides and cycloaliphatic or aliphatic thiols having, in particular, 2 to 24 carbon atoms, and optionally having another functional group chosen among the amino, hydroxy and carboxy groups. The invention further relates to a pharmaceutical composition comprising at least one polymer according to the invention, in association with a pharmaceutically acceptable vehicle, advantageously for a parenteral administration. The invention further relates to a kit comprising a pharmaceutical composition comprising the polymer according to the invention in association with a pharmaceutically acceptable vehicle for a parenteral administration, and an injection means.
A61K 49/04 - Préparations de contraste pour rayons X
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
The invention relates to non-biodegradable embolisation microspheres comprising a cross-linked matrix, the matrix being based on at least: a) from 20% to 95% of hydrophilic monomer; b) from 1% to 15% of a non-biodegradable hydrophilic cross-linking monomer; and c) from 1.5% to less than 6% of transfer agent selected from alkyl halides and cycloaliphatic or aliphatic thiols having in particular from 2 to 24 carbon atoms, and optionally having another functional group selected from amino, hydroxy and carboxy groups. The invention further relates to a pharmaceutical composition comprising non-biodegradable embolisation microspheres according to the invention in conjunction with a pharmaceutically acceptable vehicle, advantageously for parenteral administration. The invention further relates to a kit comprising a pharmaceutical composition comprising non-biodegradable embolisation microspheres according to the invention in conjunction with a pharmaceutically acceptable vehicle for parenteral administration, and at least one injection means.
C08F 293/00 - Composés macromoléculaires obtenus par polymérisation sur une macromolécule contenant des groupes capables d'amorcer la formation de nouvelles chaînes polymères rattachées exclusivement à une ou aux deux extrémités de la macromolécule de départ
39.
METHOD FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE AND A CONTRAST IMAGE RESPECTIVELY DEPICTING A BODY PART PRIOR TO AND AFTER AN INJECTION OF A FIRST DOSE OF CONTRAST AGENT
The present invention relates to method for medical imaging, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining at least one candidate pre-contrast image and a candidate contrast image respectively depicting a body part prior to and after an injection of a first dose of contrast agent, wherein said first dose is higher than a predetermined low dose, the predetermined reduced dose being lower than a predetermined standard dose; a convolutional neural network, CNN, being trained to reconstruct, from at least a pre-contrast input image and a low dose contrast input image respectively depicting a body part prior to and after an injection of said low dose of contrast agent, a standard dose contrast image depicting said body part after an injection of said standard dose of contrast agent; (b) Simulating an injection of a second dose of contrast agent which is higher than the standard dose, wherein said simulating comprises generating a synthetic contrast image by applying the CNN to the at least one candidate pre-contrast image and the candidate contrast image.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
40.
Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
A syringe comprising: a body delimiting a chamber; a piston able to slide in the chamber of the body along a longitudinal axis of the syringe, wherein the piston comprises a rod, a head, and a finger rest, which are all in one piece; and a deformable retention device designed to prevent the piston from leaving the body entirely, wherein the retention device is force-fitted in the chamber, extends around the piston over an angular sector strictly greater than 180° when it is in the assembled position, and has protruding external ribs which extend parallel to the longitudinal axis and are plastically deformable when the retention device is assembled in the chamber.
An injection device (1) for delivering a medical fluid, comprising an interface module (4) configured to receive a syringe (6), the interface module (4) defining a reception space (40) adapted to receive a flange (12a) in the outer periphery of a barrel (10) of the syringe (6), a drive member (8) configured to couple a piston of the syringe, and to translate along a longitudinal axis (X). The interface module (4) comprises a lateral opening (46) defined between two supporting members (50) of the interface module (4) and extending radially in a first radial direction from the longitudinal axis (X), said lateral opening (46) adapted for a radial translation of the syringe (6) in the first radial direction to a loaded position in which the flange (12a) of the syringe (6) is received in the reception space and the barrel (10) of the syringe (6) extends along the longitudinal axis (X).
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Software used for assisting radiology activity and
diagnosis; artificial intelligence software. Surgical and medical apparatus and instruments; medical
devices for assisting radiology activity and diagnosis. Providing access to medical databases; transmission and
reception [transmission] of medical database information via
a telecommunication network; telecommunications services for
providing access to databases; provision of access to
databases on computer networks; provision of access to
on-line computer databases; transmission of database
information via telecommunication networks; electronic
transmission of messages, data and documents; rental of
message sending apparatus; all the aforesaid services being
provided or related to the medical field. Design and development of software; installation of
software, maintenance of software, updating of software,
software as a service (SaaS) for use in the medical field,
rental of software for medical use; development of software
application solutions; software as a service [SaaS] enabling
the interpretation of images obtained in the context of
medical imaging procedures; providing temporary use of
online non-downloadable and/or downloadable software for
processing, interpreting and managing data produced by
putting into operation medical imaging procedures;
scientific research; technological research; engineering
services; research in the field of artificial intelligence;
advice in the field of technological development; design and
development of engineering products; all the aforesaid
services being provided or connected with the medical field. Medical and health services; medical information;
information in the field of health; information services
with respect to diagnostic products for medical use; rental
services of all kinds with regard to medical apparatus and
devices; rental services for medical diagnostic apparatus
and instruments; radiology activity assistance services.
44.
MACROCYCLIC LIGANDS WITH PICOLINATE GROUP(S), COMPLEXES AND MEDICAL USES THEREOF
The present invention relates to new macrocyclic ligands substituted with at least one picolinate group, to the radioactive complexes thereof and to the uses thereof in medical imaging and/or in therapy, in particular in interventional radiology. The present invention also relates to a new process for preparing ligands according to the invention, and also to the preparation intermediates thereof.
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
45.
METHODS FOR TRAINING A PREDICTION MODEL, OR FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE DEPICTING A BODY PART PRIOR TO AN INJECTION OF CONTRAST AGENT USING SAID PREDICTION MODEL
The present invention relates to a method for processing at least a pre-contrast image depicting a body part prior to an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining said pre-contrast image; (b) Determining, by application of a prediction model to said pre-contrast image candidate value(s) of at least one injection parameter of said injection of contrast agent, such that the sequence of said pre-contrast image and at least a contrast image depicting said body part during injection of contrast agent in accordance with the determined candidate value(s) of said injection parameter(s) minimizes a radiation dose.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
46.
METHODS FOR TRAINING A TOMOSYNTHESIS RECONSTRUCTION MODEL, OR FOR GENERATING AT LEAST ONE CONTRAST TOMOGRAM DEPICTING A TARGET BODY PART DURING AN INJECTION OF CONTRAST AGENT
The present invention relates to a method for generating at least one contrast tomogram depicting a target body part during an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining a pre-contrast tomogram of said target body part prior to the injection of contrast agent, and raw projection data acquired over a limited rotation angle span during the injection of contrast agent; (b) Segmenting said target body part on the pre-contrast tomogram; (c) Generating the contrast tomogram, by application of a tomosynthesis reconstruction model to said segmented pre- contrast tomogram and the obtained raw projection data.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Contrast products used in the field of magnetic resonance
imaging (MRI). Medical device intended for injection of pharmaceutical
products for medical use.
48.
Lesion detection artificial intelligence pipeline computing system
A lesion detection and classification artificial intelligence (AI) pipeline comprising a plurality of trained machine learning (ML) computer models is provided. First ML model(s) process an input volume of medical images (VOI) to determine whether VOI depicts a predetermined amount of an anatomical structure. The AI pipeline determines whether criteria, such as a predetermined amount of an anatomical structure of interest being depicted in the input volume, are satisfied by output of the first ML model(s). If so, lesion processing operations are performed including: second ML model(s) processing the VOI to detect lesions which correspond to the anatomical structure of interest; third ML model(s) performing lesion segmentation and combining of lesion contours associated with a same lesion; and fourth ML models processing the listing of lesions to classify the lesions. The AI pipeline outputs the listing of lesions and the classifications for downstream computing system processing.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Provision of access to medical databases; transmission and reception of medical database information via a telecommunication network; Telecommunication services for providing access to medical databases; Provision of access to addresses in medical databases over computer networks; Provision of access to computer databases online featuring medical information; Transmission of database information via telecommunication networks; Electronic transmission for messages, data and documents; Leasing of apparatus for electronic transmission of messages; all in relation with the medical field Recorded software and AI (artificial intelligence) software for viewing, analysing, diagnostic, reporting and planning, storing, and processing of radiology images Medical imaging apparatus for use in the field of radiology for image viewing and assessment; medical image processors; Medical apparatus, namely, medical imaging apparatus, medical diagnostic apparatus, radiological apparatus Design and development of software for use in the medical field; installation of software, maintenance of software, updating of software; software as a service (SAAS) services featuring software for use in the medical field for viewing, analyzing, diagnostic, reporting and planning, storing, and processing of radiology images Medical services; medical information services relating to diagnostic products for medical use; medical radiology services; diagnostic medical imaging services; medical imaging services; mobile medical imaging services
50.
METHODS FOR TRAINING A CNN AND FOR PROCESSING AN INPUTTED PERFUSION SEQUENCE USING SAID CNN
The present invention relates to a method for processing an inputted perfusion sequence, by means of a convolutional neural network, CNN, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (b) extracting, using an encoder branch of the CNN, a plurality of initial n+1-dimensional features maps representative of the inputted perfusion sequence at different scales, n≥3, said CNN further comprising a decoder branch and skip connections between the encoder branch and the decoder branch, each skip connection projecting the initial n+1-dimensional features maps into initial n- dimensional feature maps; (c) generating, using said decoder branch of the CNN, a plurality of enriched n-dimensional feature maps also representative of representative of the inputted perfusion sequence at different scales, each enriched n-dimensional feature map incorporating the information from the initial n-dimensional feature maps of smaller or equal scale; (d) generating at least one quantitative map of the inputted perfusion sequence from the largest-scale enriched n-dimensional feature maps.
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
METHODS FOR TRAINING AT LEAST A PREDICTION MODEL FOR MEDICAL IMAGING, OR FOR PROCESSING AT LEAST A PRE-CONTRAST IMAGE DEPICTING A BODY PART PRIOR TO AN INJECTION OF CONTRAST AGENT USING SAID PREDICTION MODEL
The present invention relates to a method for processing at least a pre- contrast image depicting a body part prior to an injection of contrast agent, the method being characterized in that it comprises the implementation, by a data processor (11b) of a second server (1b), of steps of: (a) Obtaining said pre-contrast image; (b) Determining candidate value(s) of at least one injection parameter of said injection of contrast agent by application of a prediction model to said pre-contrast image, such that a theoretical contrast image depicting said body part during injection of contrast agent in accordance with the determined candidate value(s) of said injection parameter(s) is expected to present a target quality level.
G01R 33/56 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne
G01R 33/563 - Amélioration ou correction de l'image, p. ex. par des techniques de soustraction ou d'établissement de moyenne de matériaux en mouvement, p. ex. angiographie à écoulement contrasté
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
The present invention relates to an embolizing emulsion comprising iodinated oil and an aqueous phase comprising a water-soluble contrast agent for use in the treatment of inflammatory hypervascularization associated with a musculoskeletal disorder.
A61P 19/00 - Médicaments pour le traitement des troubles du squelette
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61K 31/201 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p. ex. acides oléique ou linoléique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Contrast products used in the field of magnetic resonance imaging (MRI) Medical device intended for injection of pharmaceutical products for medical use
54.
Seed relabeling for seed-based segmentation of a medical image
A mechanism is provided for seed relabeling for seed-based slice-wise lesion segmentation. The mechanism receives a lesion mask for a three-dimensional medical image volume. The lesion mask corresponds to detected lesions in the medical image volume and wherein each detected lesion has a lesion contour. The mechanism generates a distance map for a given two-dimensional slice in the medical image volume based on the lesion mask. The distance map comprises a distance to a lesion contour for each voxel of the given two-dimensional slice. The mechanism performs local maxima identification to select a set of local maxima from the distance map such that each local maximum has a value greater than its immediate neighbor points. The mechanism performs seed relabeling based on the distance map and the set of local maxima to generate a set of seeds. Each seed represents a center of a distinct component of a lesion contour. The mechanism performs image segmentation on the lesion mask based on the set of seeds to form a split lesion mask.
G06T 7/187 - DécoupageDétection de bords impliquant des croissances de zonesDécoupageDétection de bords impliquant des fusions de zonesDécoupageDétection de bords impliquant un étiquetage de composantes connexes
G06T 19/20 - Édition d'images tridimensionnelles [3D], p. ex. modification de formes ou de couleurs, alignement d'objets ou positionnements de parties
G06F 18/2413 - Techniques de classification relatives au modèle de classification, p. ex. approches paramétriques ou non paramétriques basées sur les distances des motifs d'entraînement ou de référence
55.
Ensemble machine learning model architecture for lesion detection
A lesion detection ensemble machine learning model architecture comprising a plurality of trained machine learning (ML) computer models is provided. A first decoder of a lesion detection ML model processes a medical image input to generate a first lesion mapping prediction. A second decoder of the lesion detection ML model processes the medical image input to generate a second lesion mapping prediction. Combinational logic combines the first and second lesion mapping predictions to generate a combined prediction. Final lesion mapping output logic generates a final lesion prediction based on the combined lesion mapping prediction. The final lesion mapping output logic outputs the final lesion prediction for further downstream computing operations. The first decoder is trained with a first loss function that is configured to counterbalance a training of the second decoder that is trained using a second loss function different from the first loss function.
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
56.
Lesion detection artificial intelligence pipeline computing system
A lesion detection and classification artificial intelligence (AI) pipeline comprising a plurality of trained machine learning (ML) computer models is provided. First ML model(s) process an input volume of medical images (VOI) to determine whether VOI depicts a predetermined amount of an anatomical structure. The AI pipeline determines whether criteria, such as a predetermined amount of an anatomical structure of interest being depicted in the input volume, are satisfied by output of the first ML model(s). If so, lesion processing operations are performed including: second ML modal(s) processing the VOI to detect lesions which correspond to the anatomical structure of interest; third ML model(s) performing lesion segmentation and combining of lesion contours associated with a same lesion; and fourth ML models processing the listing of lesions to classify the lesions. The AI pipeline outputs the listing of lesions and the classifications for downstream computing system processing.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
A false positive removal engine is provided. The false positive removal engine receives detected objects in one or more images. A machine learning classifier computer model, configured with first operational parameters to implement a first operating point, processes the received input to classify each detected object as being a true positive or a false positive to generate a first set of object classifications. If the first set is empty, the false positive removal engine outputs the first set as a filtered list of objects; otherwise the ML classifier computer model is configured with second operational parameters to implement a second operating point, different from the first operating point, which then processes the received input to classify each detected object and generate a second set of objects classified as true positive, which is output by the false positive removal engine as the filtered list of objects.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 70/60 - TIC spécialement adaptées au maniement ou au traitement de références médicales concernant des pathologies
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G06F 18/21 - Conception ou mise en place de systèmes ou de techniquesExtraction de caractéristiques dans l'espace des caractéristiquesSéparation aveugle de sources
An injection device (1) for injecting a medical liquid, comprising: - a piston (6) arranged within an inner space (4) delimiting an upper space (4b) and a lower space (4a), - an evacuation path, said evacuation path traversing the piston (6) the lower space (4a) to the upper space (4b) of the inner space, - a selector (24) between a lower portion (17a) and an intermediate portion (17b) of the evacuation path, configured for selectively allowing the gas to go through and preventing the medical liquid from going through said selector (24, 50, 60), - a purge valve (22) between the intermediate portion (17b) of the evacuation path and an upper portion (17c) of the evacuation path and configured for moving between a blocking and a passing configuration which requires an overpressure in the intermediate portion (17b) caused by the piston (6) travelling towards the lower end of the body (2).
A61M 5/14 - Dispositifs de perfusion, p. ex. perfusion par gravitéPerfusion sanguineAccessoires à cet effet
A61M 5/142 - Perfusion sous pression, p. ex. utilisant des pompes
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
59.
COMPLEX OF GADOLINIUM AND A CHELATING LIGAND DERIVED OF A DIASTEREOISOMERICALLY ENRICHED PCTA AND SYNTHESIS METHOD
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical products, medical and veterinary
preparations; diagnostic products for medical use; contrast
diagnostic products for use in radiology; products for
magnetic resonance imaging; hygienic products for medicine;
disinfectants for medical or sanitary use (other than
soaps). Surgical, medical and veterinary apparatus and instruments;
injectors for contrast media used in medical imaging
procedures; medical devices, namely, catheters, micro
catheters and guidewires. Advertising and sales promotion, including sales of
advertising space on electronic medical and pharmaceutical
platforms; commercial intermediary services especially via
an online platform for supply and demand in the medical and
pharmaceutical sector, in the field of medicine, medical
equipment and devices and sales market research relating
thereto; commercial intermediary services especially by
means of online platforms for the supply and demand of
medical and pharmaceutical information; update and
management of data in computer databases in the medical and
pharmaceutical field; commercial business management;
commercial administration; administrative services;
subscription services for access to medical and
pharmaceutical platforms on the Internet; all of the
aforesaid services including services with respect to
medical, veterinary medicine and pharmaceutical products and
services; provision of business information and other
information concerning pharmaceutical products and medical
devices in connection with medical imaging. Design and development of computer software intended for the
medical field; installation of software, maintenance of
software, software updating, rental of software used for
medical purposes; development of software application
solutions; software as a service [SaaS] for enabling the
interpretation of images obtained in medical imaging
procedures; provison of temporary use of on-line
non-downloadable software for processing, interpreting and
managing data produced by the implementation of medical
imaging procedures.
61.
Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
A medical container assembly is disclosed having an adapter assembly that fluidly connects with a medical container having a volume of medical fluid to accommodate multiple injections. The adapter assembly includes a spike assembly (300) that fluidly connects with the medical container, along with a spike interface cover (200) that detachably connects with the spike assembly (300). Features are incorporated by the spike assembly (300) to reduce the potential that the spike assembly (300) will be used with multiple medical containers. The spike interface cover (200) is detachably connected with the spike assembly (300) and includes features that allows the spike interface cover (200) to be used with a spike assembly (300) installed on one container, and to thereafter allow this same spike interface cover (200) to be used with another spike assembly (300) installed on another container.
The present invention relates to a method for preparing the macrocyclic ligand of formula (L) comprising i) decomplexing the complex of formula (II) consisting of at least 80% of a diastereoisomeric excess comprising a mixture of isomers ll-RRR and ll-SSS of formulae (IISSS) (II-RRR), ii) eliminating the gadolinium salt formed during step i), for example by filtration, and iii) recovering the free macrocyclic ligand of formula (L). The present invention also relates to a composition comprising the diastereoisomerically enriched complex of formula (II) and the macrocyclic ligand of formula (L).
The present invention relates to a method for preparing a 2-bromoglutaric acid diester of formula (I), comprising forming a 2-hydroxyglutaric acid diester of formula (II) by reacting butyrolactone acid of formula (BA) with alcohol of formula ROH, in the presence of an acid such as sulphuric acid; and brominating the 2-hydroxyglutaric acid diester of formula (II) by bubbling gaseous hydrobromic acid. The present invention further comprises a 2-bromoglutaric acid diester of formula (I) having a degree of purity determined by HPLC analysis that is greater than or equal to 90%.
C07C 67/08 - Préparation d'esters d'acides carboxyliques par réaction d'acides carboxyliques ou d'anhydrides symétriques avec le groupe hydroxyle ou O-métal de composés organiques
C07C 67/307 - Préparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par introduction d'atomes d'halogènePréparation d'esters d'acides carboxyliques par modification de la partie acide de l'ester sans introduction d'un groupe ester par substitution d'atomes d'halogène par des atomes d'autres halogènes
C07C 69/62 - Esters contenant des atomes d'halogène
C07C 69/675 - Esters d'acides carboxyliques dont le groupe carboxyle estérifié est lié à un atome de carbone acyclique et dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide d'acides saturés d'acides hydroxycarboxyliques saturés
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
35 - Publicité; Affaires commerciales
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical products, namely, diagnostic preparations for medical purposes, contrast media for use with medical equipment, and medical and veterinary preparations for the detection, treatment and monitoring of liver tumors; diagnostic preparations for medical use; contrast diagnostic substances and media for use in radiology; imaging agents for magnetic resonance imaging; disinfectants for medical or sanitary use, other than soaps Surgical apparatus and instruments; medical and veterinary apparatus and instruments, namely, microcatheters and injectors; medical devices in the nature of injectors for use with contrast media used in medical imaging procedures; medical devices, namely, catheters, micro catheters and guidewires Advertising and sales promotion services, including provision of advertising space on electronic medical and pharmaceutical platforms; commercial intermediary services, namely, distributorships, via an online platform for supply and demand in the medical and pharmaceutical sector, in the field of medicine, medical equipment and devices and sales market research relating thereto; commercial intermediary services, namely, distributorship, by means of online platforms for the supply and demand of medical and pharmaceutical information; update and management of data in computer databases in the medical and pharmaceutical field; commercial business management; commercial business administration; business administrative services; arranging subscriptions to telecommunication services for others for access to medical and pharmaceutical platforms on the Internet; all of the aforesaid services in the field of medical, veterinary medicine and pharmaceutical products and services; provision of business information and other business information concerning pharmaceutical products and medical devices in connection with medical imaging Design and development of computer software intended for the medical field; installation of software, maintenance of software, software updating, rental of software used for medical purposes; development of software application solutions; software as a service (SAAS) services featuring software for enabling the interpretation of images obtained in medical imaging procedures; provision of temporary use of on-line non-downloadable software for processing, interpreting and managing data produced by the implementation of medical imaging procedures
66.
Method of determining contrast phase of a computerized tomography image
A computer-implemented method for classifying and presenting a contrast phase (CP) of a contrast enhanced computerized tomography (CECT) scan is provided. The method includes training an artificial intelligence (AI) algorithm utilizing a set of CPs labeled CECT data to associate a set of characteristics of the data with a probability associated with the CP. The method includes receiving a new set of unlabeled CECT data, and applying the AI algorithm to the new unlabeled CECT data to associate a first probability of a first CP and a second probability of a second CP. The method also includes providing a graphical representation including the first probability of the first CP and the second probability of the second CP.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
36 - Services financiers, assurances et affaires immobilières
37 - Services de construction; extraction minière; installation et réparation
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Software; computer software and applications; downloadable
computer software applications; downloadable applicationS
software for smartphones; computer software for information
management; data processing software. Inventory management and control services in the field of
medical devices and equipment; providing technicians and
specialists in medical apparatus and devices (providing
temporary use of persons). Financial services; financing services; hire-purchase
financing (leasing); financial payment services; payment
processing; remote payment services; payment
administration services; payment services provided via
wireless telecommunication apparatus and devices; electronic
payment services; electronic payment processing. Providing information and consultancy with respect to the
installation and repair of computer hardware and medical
equipment; support services, namely, troubleshooting in the
nature of repair of medical equipment; repair services for
medical devices; technical support services, namely,
providing technical advice in connection with the repair of
medical devices; repair, servicing and maintenance of
medical devices; all the aforesaid services may be provided
by telephone, the Internet or any other means of
communication. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; exchange of electronic voice, audio and video
content, data, graphics and text that can be accessed via
computer telecommunications networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and
information by computer and electronic communication means;
transfer of information and data via on-line services and
the Internet; satellite transmission; communication by
computer terminals; services for downloading digitalized
data; providing access to a computer network; provision of
access to information via data networks; provision of
access to information in computer networks. Training services in the field of installation, operation,
maintenance and repair of medical equipment; all the
aforesaid services may be provided by telephone, the
Internet or any other means of communication; training in
the use and operation of medical equipment and consultancy
relating thereto; educational services, namely, conducting
classes, seminars, conferences, exhibitions and workshops in
the field of medical devices as well as distribution of
training material relating thereto; educational services,
namely, providing on-line instructions in the field of
medical devices; providing on-line digital publications in
the nature of brochures, newsletters, and magazines in the
field of medical devices via the Internet; interactive
online training courses in the field of medical devices;
providing online non-downloadable educational video clips in
relation to medical devices. Support services, namely, technical support in the field of
repair, installation and maintenance of computer software;
providing computer technology troubleshooting center
services; technical support services, namely,
troubleshooting in the nature of diagnosing problems with
medical equipment; certification [quality control];
conducting quality control tests of products and services in
the field of medical devices; design and development of
medical diagnostic apparatus and medical devices; design
and development of medical technologies; engineering
services in the field of medical devices; research and
development services in the field of medical devices;
evaluation of the performance of medical devices; project
management in the field of medical devices; risk assessment
in the field of medical devices; laboratory research
services concerning medical devices; diagnostic testing
services; software design, especially relating to medical
apparatus and instruments; installation and maintenance of
software, especially for medical apparatus and instruments;
advisory and technical support services for the use,
application and maintenance of software, especially for
medical apparatus and instruments; maintenance of software
and development of technical program solutions, especially
relating to medical apparatus and instruments; all the
aforesaid services may be provided by telephone, the
Internet or any other means of communication. Rental services of all kinds with regard to medical
apparatus and devices; rental services for medical
diagnostic apparatus and instruments; rental services for
surgical instruments and apparatus; rental services for
medical apparatus and instruments for hospital use; rental
of veterinary apparatus and instruments; rental services
for auxiliary medical devices.
68.
Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process
The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
The present invention relates to a complex of formula (II) constituted of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae:
The present invention also relates to a process for preparing said complex of formula (II), and also to two synthetic intermediates.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
Mechanisms are provided to implement an automated medical image processing pipeline selection (MIPPS) system. The MIPPS system receives medical image data associated with a patient electronic medical record and analyzes the medical image data to extract evidence data comprising characteristics of one or more medical images in the medical image data indicative of a medical image processing pipeline to select for processing the one or more medical images. The evidence data is provided to a machine learning model of the MIPPS system which selects a medical image processing pipeline based on a machine learning based analysis of the evidence data. The selected medical image processing pipeline processes the medical image data to generate a results output.
A process for preparing an organo-iodinated compound, comprising the following steps:
a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:
to obtain an intermediate compound Ya;
b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;
c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; and
d) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.
C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
The invention relates to non-biodegradable embolisation microspheres comprising a cross-linked matrix, the matrix being based on at least: a) from 20% to 95% of hydrophilic monomer; b) from 1% to 15% of a non-biodegradable hydrophilic cross-linking monomer; and c) from 1.5% to less than 6% of transfer agent selected from alkyl halides and cycloaliphatic or aliphatic thiols having in particular from 2 to 24 carbon atoms, and optionally having another functional group selected from amino, hydroxy and carboxy groups. The invention further relates to a pharmaceutical composition comprising non-biodegradable embolisation microspheres according to the invention in conjunction with a pharmaceutically acceptable vehicle, advantageously for parenteral administration. The invention further relates to a kit comprising a pharmaceutical composition comprising non-biodegradable embolisation microspheres according to the invention in conjunction with a pharmaceutically acceptable vehicle for parenteral administration, and at least one injection means.
A61L 24/06 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons carbone-carbone non saturées
C08F 220/00 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et un seul étant terminé par un seul radical carboxyle ou un sel, anhydride, ester, amide, imide ou nitrile
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
The invention relates to a polymer comprising a crosslinked matrix, the matrix being based on at least: a) 20 to 90% hydrophilic monomer; b) 5 to 50% radio-opaque halogenated monomer; c) 1 to 15% non-biodegradable hydrophilic crosslinking agent; and d) 0.1 to 10% transfer agent chosen among the alkyl halides and cycloaliphatic or aliphatic thiols having, in particular, 2 to 24 carbon atoms, and optionally having another functional group chosen among the amino, hydroxy and carboxy groups. The invention further relates to a pharmaceutical composition comprising at least one polymer according to the invention, in association with a pharmaceutically acceptable vehicle, advantageously for a parenteral administration. The invention further relates to a kit comprising a pharmaceutical composition comprising the polymer according to the invention in association with a pharmaceutically acceptable vehicle for a parenteral administration, and an injection means.
A61L 24/06 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons carbone-carbone non saturées
C08F 220/00 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et un seul étant terminé par un seul radical carboxyle ou un sel, anhydride, ester, amide, imide ou nitrile
A61K 49/18 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par un aspect physique particulier, p. ex. émulsions, microcapsules, liposomes
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 38/00 - Préparations médicinales contenant des peptides
78.
Determining appropriate medical image processing pipeline based on machine learning
Mechanisms are provided to implement an automated medical image processing pipeline selection (MIPPS) system. The MIPPS system receives medical image data associated with a patient electronic medical record and analyzes the medical image data to extract evidence data comprising characteristics of one or more medical images in the medical image data indicative of a medical image processing pipeline to select for processing the one or more medical images. The evidence data is provided to a machine learning model of the MIPPS system which selects a medical image processing pipeline based on a machine learning based analysis of the evidence data. The selected medical image processing pipeline processes the medical image data to generate a results output.
The present invention relates to novel lipophilic macrocyclic ligands, the complexes thereof, in particular radioactive complexes, and the uses of same in medical imaging and/or in therapy, in particular in interventional radiology.
C07D 257/02 - Composés hétérocycliques contenant des cycles comportant quatre atomes d'azote comme uniques hétéro-atomes du cycle non condensés avec d'autres cycles
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
The present invention relates to a complex having formula (II), consisting of at least 90% of a diastereoisomeric excess comprising a mixture of II-RRR and II-SSS isomers having the formulas: (II-SSS) (II-RRR). The present invention also relates to a process for preparing and purifying said complex of formula (II) and to a composition comprising said complex.
A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
The present invention relates to a complex having formula (II), consisting of at least 80% of a diastereoisomeric excess comprising a mixture of isomers II-RR and II-SSS having the formulae: The present invention also relates to a method for preparing said complex having formula (II) and to two synthetic intermediates.
A61K 49/08 - Préparations de contraste pour la résonance magnétique nucléaire [RMN]Préparations de contraste pour l'imagerie par résonance magnétique [IRM] caractérisées par le support
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, medical and veterinary
preparations, diagnostic products for medical use,
diagnostic contrast products for use in radiology, products
intended for magnetic resonance imaging; sanitary products
for medical purposes; dietetic substances and foodstuffs
for medical use, food for babies; plasters, materials for
dressings; material for dental fillings and dental
impressions; disinfectants for medical or sanitary use
(other than soaps). Software; software (computer programs) for medical
management. Surgical, medical, dental and veterinary apparatus and
instruments; Medical devices for use with pharmaceutical or
diagnostic products. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; exchange of electronic voice, audio and video
content, data, graphics and text that can be accessed via
computer telecommunications networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and
information by computer and electronic communication means;
transfer of information and data via on-line services and
the Internet; satellite transmission; communication by
computer terminals; services for downloading digitalized
data; providing access to a computer network; provision of
access to information via data networks; provision of
access to information in computer networks. Scientific studies and research relating to medical imaging;
chemical studies and research; consultancy, studies and
research relating to pharmacy, medicine, biology, chemistry,
radiology, magnetic resonance imaging; design and
development of computer software intended for the medical
field; installation of software, maintenance of software,
software updating, rental of software used for medical
purposes; biological research services; biological and
chemical analysis services. Medical, hygiene and beauty care for human beings; medical
analysis services; radiological, magnetic resonance imaging
and medical examinations; information services relating to
health, healthcare services.
83.
UNIK Tailored interconnected solution driving your journey to excellence
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, medical and veterinary
preparations, diagnostic products for medical use,
diagnostic contrast products for use in radiology, products
intended for magnetic resonance imaging; sanitary products
for medical purposes; disinfectants for medical or sanitary
use (other than soaps). Software; medical management software (computer programs);
software used in radiology centers for collection and
management of data relating to patient treatment; Software
for controlling and monitoring the quantities of ionizing
radiation administered to patients. Surgical, medical, dental and veterinary apparatus and
instruments; Medical devices for use with pharmaceutical or
diagnostic products; injectors for contrast media used in
medical imaging procedures. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; exchange of electronic voice, audio and video
content, data, graphics and text that can be accessed via
computer telecommunications networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and
information by computer and electronic communication means;
transfer of information and data via on-line services and
the Internet; satellite transmission; communication by
computer terminals; services for downloading digitalized
data; providing access to a computer network; provision of
access to information via data networks; provision of
access to information in computer networks. Scientific studies and research relating to medical imaging;
chemical studies and research; consultancy, studies and
research relating to pharmacy, medicine, biology, chemistry,
radiology, magnetic resonance imaging; design and
development of computer software intended for the medical
field; installation of software, maintenance of software,
software updating, rental of software used for medical
purposes; biological and chemical analysis services;
biological research services. Medical services; medical analysis services; radiological,
magnetic resonance imaging and medical examinations;
information services relating to health, healthcare
services.
84.
Reinforced macrocyclic ligands, complexes thereof, and uses of same
Centre national de la recherche scientifique (France)
Inventeur(s)
Tripier, Raphaël
Rousseaux, Olivier
Le Fur, Mariane
Beyler, Maryline
Fougère, Olivier
Nizou, Gwladys
Abrégé
Ligands that are based on the pyclen macrocycle that are reinforced, which are useful for complexing elements such as radioelements and/or elements with magnetic properties.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
A system for generating simulated body parts for images may include a body part recognition convolutional neural network (CNN) to recognize a body part in an input image. The body part recognition CNN may be trained using first training data including training images including body parts contained in the input image being identified. The system may also include a body part generative adversarial network (GAN) to complete an image of the body part in the input image based on a body part identification output by the body part recognition CNN. The body part GAN may be trained using second training data including at least partial training images.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
A61K 31/439 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle formant une partie d'un système cyclique ponté, p. ex. quinuclidine
A61K 36/66 - Papaveraceae (famille du pavot), p. ex. sanguinaire du Canada
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
87.
UNIK TAILORED INTERCONNECTED SOLUTION DRIVING YOUR JOURNEY TO EXCELLENCE
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, namely, contrast media for medical use; medical and veterinary pharmaceutical preparations, namely, contrasting agent for ultrasound diagnostic imaging; diagnostic preparations for medical use; diagnostic contrast products for use in radiology, namely radiological contrast substances for medical purposes; products intended for magnetic resonance imaging, namely, imaging agents for magnetic resonance imaging (MRI); sanitary preparations for medical purposes; disinfectants for medical or sanitary use Downloadable and recorded software for medical imaging apparatus; medical management software, namely downloadable and recorded software for maintaining medical records; downloadable and recorded software used in radiology centers for collection and management of data relating to patient treatment; downloadable and recorded software for controlling and monitoring the quantities of ionizing radiation administered to patients Surgical, medical, dental and veterinary apparatus and instruments, namely, medical imaging apparatus, MRI apparatus for medical purposes, and ultrasound diagnostic apparatus; medical devices for use with pharmaceutical or diagnostic products, namely, electromagnetic medical diagnostic imaging apparatus; medical fluid injectors sold empty for use with contrast media used in medical imaging procedures Electronic data transmission and transfer of data by telecommunication; electronic exchange of data stored in databases accessible via telecommunication networks; secure electronic messaging services; exchange of electronic voice, audio and video content, data, graphics and text that can be accessed via computer telecommunications networks, namely, electronic exchange of medical records across a nationwide health information network; electronic data transmission featuring the transmission of computerized documents; transmission of data and information by computer and electronic communication means; transfer of information and data via the Internet; satellite transmission; communication by computer terminals; services for downloading digitalized data, namely, transmission of audio and video tethered downloads; providing access to a computer network being telecommunication access services; provision of access to information via data networks being telecommunication access services; provision of access to information in computer networks being telecommunication access services Scientific study and research relating to medical imaging, chemical research; scientific research consultancy and study relating to pharmacy, medicine, biology, chemistry, radiology, and magnetic resonance imaging design and development of computer software intended for the medical field; installation of software, maintenance of software, software updating and rental of software used for medical purposes; biological and chemical analysis services; biological research services Medical services; medical analysis services for diagnosis and treatment purposes provided by medical laboratories; medical services in the nature of radiological, magnetic resonance imaging and medical examinations; information services relating to health, healthcare services
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, namely, contrast media for medical use; medical and veterinary preparations, namely, contrasting agent for ultrasound diagnostic imaging; diagnostic products for medical use, namely, medical diagnostic reagents ; contrast diagnostic agent for use in radiology ; products being imaging agents for magnetic resonance imaging; sanitary preparations for medical purposes; dietetic beverages and foods for medical use; food for babies; medical plasters; materials being bandages for dressings; material for dental fillings and dental impressions; disinfectants for medical or sanitary use other than soaps Downloadable computer software for medical imaging apparatus; downloadable computer programs being software for medical management of patient information Surgical, medical, dental and veterinary apparatus and instruments, namely, medical imaging apparatus, MRI apparatus for medical purposes, and ultrasound diagnostic apparatus; Medical devices for use with pharmaceutical or diagnostic products, namely, electromagnetic medical diagnostic imaging apparatus ; medical and surgical devices, namely, microspheres used in embolization Electronic data transmission and telecommunication services, namely, wireless telephone services; electronic exchange of data stored in databases accessible via telecommunication networks; secure electronic messaging services; electronic exchange of voice, audio and video content, data, graphics and text accessible via computer telecommunications networks; services for the electronic transmission of data, particularly, for the transmission of computerized documents; transmission of data and information by computer and electronic communication means; Transfer of information and data via on-line services and the Internet; satellite transmission; communication by computer terminals; services for downloading digitalized data, namely, transmission of audio and video tethered downloads; providing user access to a computer network; provision of multiple-user access to information via global computer data networks; provision of multiple-user access to information via global computer networks Scientific studies and research relating to medical imaging, chemical studies and research; scientific studies and research relating to pharmacy, medicine, biology, chemistry, radiology, and magnetic resonance imaging and consultancy related to such scientific studies and research; design and development of computer software intended for the medical field; installation of software, maintenance of software, software updating, rental of software used for medical purposes; biological research services; biological and chemical analysis services Medical services; hygiene and beauty care for human beings; medical analysis services for diagnosis and treatment purposes; radiological, magnetic resonance imaging and medical examination services; medical information services relating to health and healthcare services
89.
PROCESS FOR THE MONOTOPIC PREPARATION OF INTERMEDIATE ORGANO-IODINATED COMPOUNDS FOR THE SYNTHESIS OF IOVERSOL
The invention relates to a process for the preparation of organo-iodinated compounds as well as the preparation intermediates thereof. More specifically, the invention relates to a process for the preparation of organo-iodinated compounds useful as preparation intermediates in the synthesis of the contrast product ioversol.
C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
C07C 233/69 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
90.
Method for the one-pot production of organo-iodinated compounds
The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.
C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
C07C 231/12 - Préparation d'amides d'acides carboxyliques par des réactions n'impliquant pas la formation de groupes carboxamide
C07C 235/16 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone acycliques et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné le squelette carboné étant acyclique et saturé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un cycle aromatique à six chaînons
C07D 319/06 - Dioxanes-1, 3Dioxanes-1, 3 hydrogénés non condensés avec d'autres cycles
91.
Segmenting irregular shapes in images using deep region growing
A system for determining a region of interest in an image. The system includes a memory and an electronic processor. The electronic processor included in the system is connected to the memory and is configured to initialize internal states of nodes of a spatial lattice. Each node of the spatial lattice corresponds to a pixel of the image and is connected to at least one node representing a neighboring pixel of the image. The electronic processor is also configured to iteratively update, using a neural network, the internal states of each nodes in the spatial lattice using spatially gated propagation and identify the region of interest within the image based on the internal states of the nodes at a convergence of the spatial lattice.
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G06N 7/00 - Agencements informatiques fondés sur des modèles mathématiques spécifiques
G06T 7/187 - DécoupageDétection de bords impliquant des croissances de zonesDécoupageDétection de bords impliquant des fusions de zonesDécoupageDétection de bords impliquant un étiquetage de composantes connexes
Mechanisms are provided to implement an automated medical image processing pipeline selection (MIPPS) system. The MIPPS system receives medical image data associated with a patient electronic medical record and analyzes the medical image data to extract evidence data comprising characteristics of one or more medical images in the medical image data indicative of a medical image processing pipeline to select for processing the one or more medical images. The evidence data is provided to a machine learning model of the MIPPS system which selects a medical image processing pipeline based on a machine learning based analysis of the evidence data. The selected medical image processing pipeline processes the medical image data to generate a results output.
A system for determining a region of interest in an image. The system includes a memory and an electronic processor. The electronic processor is configured to create an image pyramid for the image. The image pyramid includes a plurality of layers. For each layer of the image pyramid, the electronic processor is configured to initialize internal states of nodes of a spatial lattice and iteratively update the internal states of the nodes using spatially gated propagation. Each node in the spatial lattice represents a block of pixels in the image and is connected to a node representing a neighboring block of pixels in the image. The electronic processor is also configured to identify the region of interest based on the internal states of the nodes at a convergence of the spatial lattice having nodes representing values included in a first layer of the image pyramid.
G06K 9/32 - Alignement ou centrage du capteur d'image ou de la zone image
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
05 - Produits pharmaceutiques, vétérinaires et hygièniques
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products; medical and veterinary
preparations; diagnostic products for medical use; contrast
diagnostic products for use in radiology; products for
magnetic resonance imaging; sanitary products for medical
purposes; dietetic substances and foodstuffs for medical
use, food for babies; plasters, materials for dressings;
material for dental fillings and dental impressions;
disinfectants for medical or sanitary use (other than
soaps). Software; software (computer programs) for medical
management. Surgical, medical, dental and veterinary apparatus and
instruments; Medical devices for use with pharmaceutical or
diagnostic products; medical and surgical devices, namely,
microspheres used in embolization. Data transmission and telecommunication services; electronic
exchange of data stored in databases accessible via
telecommunication networks; secure electronic messaging
services; electronic exchange of voice, audio and video
contents, data, graphics and texts accessible via computer
and telecommunication networks; services for the
transmission of data, particularly, for the transmission of
computerized documents; transmission of data and
information by computer and electronic communication means;
transfer of information and data via on-line services and
the Internet; satellite transmission; communication by
computer terminals; services for downloading digitalized
data; providing access to a computer network; provision of
access to information via data networks; provision of
access to information in computer networks. Scientific studies and research relating to medical imaging;
chemical studies and research; consultations, studies and
research in pharmacy, medicine, biology, chemistry,
radiology, magnetic resonance imaging; design and
development of computer software intended for the medical
field; installation of software, maintenance of software,
software updating, rental of software used for medical
purposes; biological research services; biological and
chemical analysis services. Medical services; hygienic and beauty care for human
beings; medical analysis services; radiological, magnetic
resonance imaging and medical examinations; information
services relating to health, healthcare services.
