The present invention relates to an oleogel composed of protein nanofibrils and ≥95% oil, without the need for an emulsifier. The present invention also relates to a method for the production of this oleogel.
A23D 7/005 - Compositions à base d'huiles ou de graisses comestibles contenant une phase aqueuse, p. ex. margarines caractérisées par des ingrédients autres que des triglycérides d'acides gras
A23D 7/02 - Compositions à base d'huiles ou de graisses comestibles contenant une phase aqueuse, p. ex. margarines caractérisées par leur production ou leur traitement
A23D 9/007 - Autres huiles ou graisses comestibles, p. ex. huiles pour cuisson caractérisées par des ingrédients autres que des triglycérides d'acides gras
A23D 9/02 - Autres huiles ou graisses comestibles, p. ex. huiles pour cuisson caractérisées par leur production ou leur traitement
2.
LIGHT BEAM PROJECTION GUIDED BIOFABRICATION OF ALIGNED TISSUES
One aspect of the invention relates to a method for making a three-dimensional hydrogel bioimplant, characterized by geometrical structures in sub-millimeter size range. The method comprises the provision of a first composition susceptible to photo-crosslinking in a container. This first composition comprises a first polymer susceptible to photo-crosslinking, a photoinitiator and optionally, a refractive index matching agent, a photo absorptive dye, and a crosslinking agent. In a first illumination step, the composition is illuminated with a plurality of spatially coherent light beams, whereby a plurality of micropillars is generated in the composition. Another aspect of the invention relates to a three-dimensional hydrogel implant comprising or essentially consisting of a plurality of microbeams of a photo-crosslinked polymer, said three-dimensional hydrogel implant obtained by a method according to the invention.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
3.
MAGNETICALLY STEERABLE DEVICE FOR USE INSIDE OF A MAMMALIAN BODY
A steerable device for use inside of a mammalian body, including: a flexible elongated element and a magnetic element placed in a distal end portion of the elongated element to allow steering by way of an external magnetic field. The steerable device includes a structured section arranged proximal to the magnetic element and having a plurality of elongated protrusions formed on an outer surface of the elongated element. The elongated protrusions have each a protrusion longitudinal axis, each protrusion longitudinal axis forming an angle with a device longitudinal axis, wherein each angle is less than 90°, such that rotation of the elongated element in the clockwise direction around the device longitudinal axis effects a movement of advancement of the elongated element relative to the soft tissue. In a further aspect, the structured section is in the form of an outer thread structure.
The invention relates to an electronic driver circuit (EDC) for driving a resonator element (XO) for providing an electronic oscillator (1). The electronic driver circuit (EDC) comprises: a synthesizer section (SYN) which is configured to receive a reference signal (XO_SIG.N, XO_SIG.P) from the resonator element (XO) and to generate a synthesizer signal (SYN_SIG) having a synthesizer frequency (SYN_F) which is equal to, lower or higher than a reference frequency (XO_F) of the reference signal (XO_SIG.N, XO_SIG.P), and having a phase resolution below or equal to 90 degrees with respect to the reference signal (XO_SIG.N, XO_SIG.P); and a pulse injection section (PJD.N, PJD.P) which is configured to inject an injection signal (INJ.N, INJ.P) into the resonator element (XO) at an injection time (T.N, T.P) which is selected using the synthesizer signal (SYN_SIG), or using the synthesizer signal (SYN_SIG) and the reference signal (XO_SIG.N, XO_SIG.P). The electronic driver circuit (EDC) enables providing an electronic oscillator (1) having improved power and noise efficiency.
H03B 5/06 - Modifications du générateur pour assurer l'amorçage des oscillations
H03B 5/36 - Production d'oscillation au moyen d'un amplificateur comportant un circuit de réaction entre sa sortie et son entrée l'élément déterminant la fréquence étant un résonateur électromécanique un résonateur piézo-électrique l'élément actif de l'amplificateur comportant un dispositif semi-conducteur
An electronic nose (1) comprises an array of sensing pixels (MOF1, MOF2, T), and electronic circuits connected to the sensing pixels (MOF1, MOF2, T) for reading the sensing pixels (MOF1, MOF2, T).
The present invention relates to compositions for use in the treatment, amelioration, and or prevention of myotonic dystrophy (DM) including DM1 and DM2. The compounds can disrupt the activity of Lin28 (e.g., Lin28A and/or Lin28B), RNA binding proteins responsible for inhibiting the maturation of miRNA precursors to mature miRNA. Upon treatment with the inventive compounds, the DM1 and DM2 cells exhibited (i) increased MEF2A expression (i.e., de-repression of MEF2A associated with DM); (ii) decreased CELF protein expression (e.g., decreased CELF1 expression); (iii) increased expression of miRNAs associated with DM and shifted the targetomes of the miRNAs toward a healthy signature; (iv) decreased expression of sodium-, potassium- and calcium ion channels with roles in myotonia, muscle wasting, and cardiac conduction; (v) increased expression of CLCN1; and (vi) decreased expression of PKC.
A61K 31/635 - Composés contenant des groupes para-N-benzènesulfonyl-N-, p. ex. sulfanilamide, p-nitrobenzènesulfonohydrazide contenant un hétérocycle, p. ex. sulfadiazine
A61K 31/5025 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes hétérocycliques
A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
7.
METHOD FOR DEPOLYMERIZING VINYL-BASED OR DIENE-BASED POLYMERS OR COPOLYMERS
C08J 11/16 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance inorganique
C07C 4/22 - Préparations d'hydrocarbures à partir d'hydrocarbures contenant un plus grand nombre d'atomes de carbone par dépolymérisation en monomère d'origine, p. ex. dépolymérisation du dicyclopentadiène pour obtenir du cyclopentadiène
8.
ANCHORING ELEMENT FOR A JOINT IMPLANT, JOINT IMPLANT AND METHOD OF MANUFACTURING THE SAME
The present invention relates to anchoring element for a joint implant, a joint implant and a method of fabrication thereof. Specifically, the anchoring element for a joint implant according to the present invention comprises a bone-facing surface designed for the attachment of the joint implant to a bone and a hydrogel-facing surface designed for the attachment to a hydrogel component, wherein at least part of the hydrogel-facing surface is designed as a porous triply periodic minimal surface. The bonding between the hydrogel and the anchoring element is achieved through chemical anchoring and mechanical hooking mechanisms.
The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH, and (b) adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry.
The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH, and (b) adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry.
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
The present invention relates to a method of obtaining keratin protein isolate from a keratin source, the method comprising: (a) preparing a first mixture comprising keratin source, chaotropic solvent, and a first reducing agent; (b) precipitating keratin protein from the first mixture; (c) preparing a second mixture comprising the keratin protein and a second reducing agent; and (d) precipitating keratin protein isolate from the second mixture. The present invention also relates to a method of obtaining keratin amyloid fibrils, the method comprising: (i) obtaining keratin protein isolate; (ii) preparing a third mixture comprising keratin protein isolate, acid solution, and a third reducing agent; and (iii) subjecting the third mixture to heat treatment to obtain keratin amyloid fibrils. The present invention also relates to a method of fabricating a membrane for an electrochemical cell or a proton conductive cell.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C08L 89/04 - Produits dérivés de déchets, p. ex. corne, sabot, cheveux ou fils
H01M 8/1004 - Éléments à combustible avec électrolytes solides caractérisés par les ensembles membrane-électrodes [MEA]
H01M 8/1069 - Matériaux d’électrolyte polymère caractérisés par le procédé de fabrication
H01M 8/1072 - Matériaux d’électrolyte polymère caractérisés par le procédé de fabrication par des réactions chimiques, p. ex. polymérisation in situ ou réticulation in situ
11.
ELECTROCHEMICAL METHOD FOR PRODUCING A NANO-OR MICRO-SHEET ELEMENT USING AN ELECTROLYTE MEMBRANE
A method for producing a nano- or micro-sheet element is provided, the nano- or microsheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising at least a growth substrate (1) and a nano- or micro-sheet layer (2). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2). In the electrochemical delamination of the laminate (14), a gas diffusion electrode (21) attached to the nano- or micro-sheet layer (2) is used as an anode and an electrolyte membrane, in particular a polymer electrolyte membrane (20), is arranged between the gas diffusion electrode (21) and the nano- or micro-sheet layer (2).
C25B 13/05 - DiaphragmesÉléments d'espacement caractérisés par le matériau à base de matériaux inorganiques
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
The invention relates to a method, system and computer program for determining a tracer flow in a measurement space, the method comprising the steps of:
a) Injecting tracers at a first injection region into the measurement space with a tracer seeding device configured to inject tracers at an adjustable injection region in the measurement space,
b) Recording the measurement space with two or more event-cameras, wherein each event-camera comprises a plurality of sensors configured to generate output data each time a sensor of the event camera senses a change in light intensity, wherein the output data comprises an information on a position of the sensor that sensed the change in light intensity, and a time of the change in light intensity,
c) From the data of the event-cameras, determining with a processor for at least some of the injected tracers a trajectory in the measurement space, wherein each trajectory comprises at least an information on a time-resolved three-dimensional position of the tracer, wherein the determination of the trajectories is facilitated in real time,
d) While executing steps b) and c), adjusting the injection region to at least a second injection region.
G01P 5/20 - Mesure de la vitesse des fluides, p. ex. d'un courant atmosphériqueMesure de la vitesse de corps, p. ex. navires, aéronefs, par rapport à des fluides en mesurant le temps mis par le fluide à parcourir une distance déterminée en utilisant des particules entraînées par un courant de fluide
G01P 5/00 - Mesure de la vitesse des fluides, p. ex. d'un courant atmosphériqueMesure de la vitesse de corps, p. ex. navires, aéronefs, par rapport à des fluides
G06F 30/20 - Optimisation, vérification ou simulation de l’objet conçu
H04N 25/47 - Capteurs d'images avec sortie d'adresse de pixelCapteurs d'images commandés par événementSélection des pixels à lire en fonction des données d'image
13.
A METHOD OF PRODUCING A MICRO-FOAMED CHEESE PRODUCT
The present invention relates to a micro-foamed cheese product and a method of producing a micro-foamed cheese product comprising providing an extruder having a gas loading zone applying a milk protein coagulate comprising milk protein, water and at least 0.8% (w/w) fat relative to the wet weight of the milk protein coagulate into the inlet of the extruder; rotating the longitudinally arranged screw to create a flow of the milk protein coagulate from the inlet to the outlet; heating the milk protein coagulate to 60°C to 140°C to melt the milk protein coagulate; dispersing a gas in the molten milk protein coagulate in the gas loading zone; and cooling the molten milk protein coagulate to obtain the micro-foamed foamed cheese product.
An electronic device (1) comprises a time-modulated receiver array (RX) or a beamforming network (BFN) connected with a time-modulated transmitter array (TX), wherein the time-modulated transmitter array (TX) includes a plurality of switches (ST1, . . . , STN) which are periodically operable between an on state (1) and an 5 off state (0) for periodic signal transmission to a plurality of antenna elements (AT1, . . . , ATN).
The present invention is generally in the fields of synthetic biology, gene therapy, and cell therapy. The invention relates, inter alia, to a synthetic transcription factor comprising a DNA binding domain derived from a mitochondrial DNA binding protein (e.g. MTERF1) and a transcriptional modulation domain derived from one or more other proteins; a nucleic acid or combination of nucleic acids encoding the inventive synthetic transcription factor; a DNA construct comprising a MTERF1 binding site and a minimal promoter; a system comprising the inventive synthetic transcription factor and the inventive DNA construct; and uses thereof, e.g. medical uses.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
A recombinant non-naturally occurring methylotrophic microorganism, which grows on reduced one-carbon (C1) compounds as sole carbon source. The recombinant microorganism expresses or over-expresses a polypeptide having methanol dehydrogenase activity, a polypeptide having 3-hexulose-6-phosphate synthase activity, and polypeptide having a 6-phospho 3-hexuloisomerase activity, and does not comprise, and/or comprises deletions or reductions of expression of, or eliminations or reductions of activity of a polypeptide having triose-phosphate-isomerase activity, and of a polypeptide having glutathione-dependent formaldehyde dehydrogenase activity.
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
A method for producing a nano- or micro-sheet element is provided, the nano- or micro-sheet element particularly being made of graphene and/or other sheet-materials. The method is based on a laminate (14) comprising a growth substrate (1), a nano- or micro-sheet layer (2) and a support layer (3). The nano- or micro-sheet layer (2) is adapted to form the nano- or micro-sheet element. The method comprises at least the step of electrochemical delamination of the laminate (14) by means of electrolysis in such a way, that the growth substrate (1) is separated from the nano- or micro-sheet layer (2) and the support layer (3). The step of electrochemical delamination of the laminate (14) is carried out with the support layer (3) having a pattern (31) with a plurality of local depressions (311) and/or elevations (312).
Methods and systems for animated figure keyframing or physical robot keyframing and learning locomotion with high-level objectives are discussed herein. For example, generating motion for an animated figure may include generating a control policy for the animated figure using a reinforcement learning model, wherein the control policy is configured to control a movement of the animated figure to achieve one or more keyframes. Generating motion for the animated figure may further include encoding the control policy onto a processor of the animated figure. In some cases, the control policy for the animated figure may be generated using a multi-input single-output transformer encoder. Generating motion for the animated figure further includes determining one or more target keyframes and generating, using the control policy, the motion for the animated figure based on the one or more target keyframes.
G05B 13/02 - Systèmes de commande adaptatifs, c.-à-d. systèmes se réglant eux-mêmes automatiquement pour obtenir un rendement optimal suivant un critère prédéterminé électriques
19.
4-OXORETINOATE FOR USE IN POST-MYOCARDIAL INFARCTION THERAPY
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E. V. (Allemagne)
Inventeur(s)
Cabezas-Wallscheid, Nina
Romero Mulero, Maria Del Carmen
Rettkowski, Jasmin
Abrégé
The present invention relates to 4-oxoretinoate for use in treatment or prevention of cardiac dysfunction, heart failure, or adverse cardiac remodelling after myocardial infarction or impaired cardiac blood flow. The present invention also relates to 4-oxoretinoate for use in treatment of coronary artery disease, or of ischemia-reperfusion injury.
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
20.
COMPOSITION FOR ABSORBING ULTRAVIOLET ELECTROMAGNETIC RADIATION, SUBSTRATE COMPRISING A COATING AND METHOD FOR PROTECTING A SURFACE OF A SUBSTRATE
nn-R with Ar, X, n and R as defined in the specification, particularly the UV absorbing agent is cinnamic acid, cinnamyl alcohol or gallic acid, or a derivative thereof. The invention further relates to a substrate comprising a coating and a method for protecting a surface of a substrate from UV electromagnetic radiation.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Sound, image or data broadcasting, reproducing or processing
apparatus; downloadable and recorded media; downloadable
videos, images, publications and books. Printing products (printed matter); books; instructional and
teaching material. Teaching; training services; entertainment services;
sporting and cultural activities; exhibition curating
services; presentation of museum exhibitions; museum
services; organization and presentation of exhibitions for
cultural purposes; cultural, educational and entertainment
services provided by art galleries; editing services;
publication of books; online provision of non-downloadable
books, publications, images and videos; online provision of
virtual guided tours; training and advice concerning methods
and techniques aimed at stimulating personal creativity;
development and conducting of art projects and exhibitions
for third parties. Scientific and technological services as well as research
and design relating thereto in the field of art and
artificial intelligence; advice with respect to artificial
intelligence.
22.
ROCKING BED, METHOD AND COMPUTER PROGRAM FOR OPERATING A ROCKING BED
A rocking bed comprising a slider-crank mechanism comprising a rotary drive and at least one four-bar linkage comprising a frame with two cranks pivotably mounted thereon via a first pivot and a second pivot, and a movable linkage pivotably connected to the cranks via a third pivot and a fourth pivot. A connecting rod of the slider-crank mechanism is pivotably connected to a support structure of the rocking bed via a sixth pivot, wherein there is a pivotable connection between the movable linkage and the support structure of the rocking bed via a fifth pivot, via which a movement of the support structure can be guided along a horizontal direction. The rotary drive has a control unit configured to realize a revolution operation of a crank of the slider-crank mechanism. A method and a computer program for operating such a rocking bed are also provided.
A47C 21/00 - Accessoires de lits, p. ex. articles pour tenir les draps, les couvertures ou dessus de litMoyens de ventilation, de refroidissement ou de chauffage reliés aux lits ou aux matelas
23.
NOVEL SENSORS SUITABLE FOR MONITORING MOVEMENT AND OTHER BIOPHYSICAL PARAMETERS
Sensors suitable to be used for wearable electronic devices. The sensor are flexible or stretchable and can be seamlessly incorporated into textiles, clothing, and wearable devices. The sensor uses helical-auxetic yarns for construction of a capacitor. The sensors can be stretchable and are suitable for use in textiles and for sensing body motion (strain).
A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01L 1/14 - Mesure des forces ou des contraintes, en général en mesurant les variations de la capacité ou de l'inductance des éléments électriques, p. ex. en mesurant les variations de fréquence des oscillateurs électriques
The present invention is directed to a method for manufacturing a bioresorbable polymeric medical implant and a polymeric composition for use in such a method. The inventive polymer blend comprises a PCL/PLA mixture in solution, and further comprises a compatibilizer. The inventive method comprises producing the inventive polymeric composition, and using said polymeric composition to form the selected implant, followed by heat treatment.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones
A photodetector (PD), comprises: a photonic layer (1) which includes a widening section (12) followed by a wide section (13), wherein the widening section (12) is configured to receive an optical signal (oS) and to distribute optical power of the optical signal (oS) to the wide section (13); a spacer layer (2) which is in contact with the wide section (13); a 2D material layer (3) which is in contact with the spacer layer (2); a plasmonic layer (4) which is in contact with the 2D material layer (3) and includes a plurality of plasmonic resonators (411, 421) which are connected via contact lines (412, 422) to connector lines (413, 423), wherein the connector lines (413, 423) enable to measure charge carriers which are generated upon receipt of the optical signal (oS).
H10F 30/22 - Dispositifs individuels à semi-conducteurs sensibles au rayonnement dans lesquels le rayonnement commande le flux de courant à travers les dispositifs, p. ex. photodétecteurs les dispositifs ayant des barrières de potentiel, p. ex. phototransistors les dispositifs étant sensibles au rayonnement infrarouge, visible ou ultraviolet les dispositifs ayant une seule barrière de potentiel, p. ex. photodiodes
H10F 77/14 - Forme des corps semi-conducteursFormes, dimensions relatives ou dispositions des régions semi-conductrices au sein des corps semi-conducteurs
The present invention relates to the provision of trifunctional crosslinker compounds comprising (i) a moiety reactive with an amino acid side chain for selective labelling of proteins, (ii) a cleavable linker moiety and (iii) an affinity moiety for the detection, isolation and purification of captured proteins. The invention further relates to uses of the cleavable crosslinking reagents in methods for detecting, labelling, identifying and characterizing proteins and protein interactions in or on the surface of intact cells, cell lysates and/or protein mixtures.
C07D 257/02 - Composés hétérocycliques contenant des cycles comportant quatre atomes d'azote comme uniques hétéro-atomes du cycle non condensés avec d'autres cycles
C07K 5/04 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés ne comportant que des liaisons peptidiques normales
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
36 - Services financiers, assurances et affaires immobilières
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
45 - Services juridiques; services de sécurité; services personnels pour individus
Produits et services
Recorded and downloadable media; computer software; computer
software for accessing computer networks and downloadable
information provided by computer networks; software
platforms; software for managing communication systems and
networks; computer software for providing online services
for social and business networks and for accessing,
uploading, downloading, sending, managing, streaming,
sharing or providing electronic works and information via
the Internet or communication networks; software for
creating virtual communities; software for the transmission
of information, audio and video data, photographic images,
texts and graphics; algorithms (software). Advertising; business management, organization and
administration; creation and management of an online
business network for professional contacts; establishing
networks of business partners; business intermediation
services; commercial intermediation services matching
potential investors with companies seeking capital; matching
students and researchers with business industry
representatives and investors; services related to business
networking; business information provided via a database or
an online electronic platform in a computer network;
compilation and systematization of data in databases and
digital platforms containing information relating to
business networks and work collaborations; providing
business information by means of a directory on a global
computer network; provision of an online marketplace;
organization of competitions and awarding of prizes for
commercial or advertising purposes; provision of an
electronic marketplace for buyers and sellers of goods and
services; compilation and systematization of data in a
database containing information relating to academic
research and development and to a virtual academic
community. Financial services; online bill payment services;
sponsorship in the form of financial support; financial
promotion; financial sponsorship in the fields of culture,
sports, science, education, development aid and research;
crowdfunding; provision of investment capital and funds for
inventors, companies and universities; providing information
on cooperation and investment opportunities via online
searchable digital platforms and databases. Telecommunication services; providing telecommunications
connections to computer networks; providing access to
computer networks, digital platforms, databases, electronic
marketplaces and electronic publications; providing chat
rooms and online forums in virtual environments and access
thereto; providing access to digital platforms, chat rooms
and online forums in virtual environments for work
collaborations; providing access to digital platforms, chat
rooms and online forums in virtual environments for The
transmission of messages relating to academic research and
development and virtual communities, including business
networks; providing access to electronic bulletin boards for
transmission of messages among users; providing
multiple-user access to a global computer network; provision
of chat rooms for social networks as well as access thereto;
transmission of information on a wide range of topics, also
online and via a global computer network; rental and free
provision of access time to data networks and digital
platforms for information and announcements relating to
academic research and development, virtual communities, work
collaboration networks and collaborations. Education; training; entertainment; sporting and cultural
activities; organization and conducting of competitions via
the Internet; organizing training and entertainment
competitions; entertainment services provided online in the
form of chat rooms. Scientific and technological services as well as research
work and design services relating thereto; industrial
analysis, industrial research and industrial design
services; design, development, provision and hosting of
digital platforms and Websites, including interactive sites,
for work collaborations in virtual environments; design and
development of computer hardware and software; design,
development and provision of non-downloadable software for
computer networks and digital platforms enabling users to
post, search, access, share and exchange electronic content
and information; computer services, namely, technological
services for creating an on-line community for users to
participate in networks; development and provision of
software applications relating to virtual communities and
social networks; creating an online community for users to
participate in networks; providing software applications for
participating in discussions, exchanges, returns, creating
virtual communities and participating in networks;
development and testing of algorithms, calculation methods
and software. Legal services; legal assistance in the drawing up of
contracts; legal services relating to licenses; moderation
of contents for Internet chat rooms.
28.
SYSTEM FOR PRODUCING SOMATOTOPIC SENSATIONS USING TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION (TENS)
System for producing somatotopic sensations using Transcutaneous Electrical Nerve Stimulation (TENS) in the lower limbs is provided, the system comprising a wearable device to be attached to a lower limb of an individual, the wearable device comprising at least two units, each comprising one or more arrays of TENS electrodes to be associated with at least one nerve of the lower limb, and wherein the system is configured to select electrodes of at least one array of electrodes, and stimulation signal parameters to be thereto, and control the stimulation of at least one nerve associated with the array of electrodes comprising the selected electrodes.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
A DNA sequence and a synthetic gene circuit (SGC) comprising the same for detecting a DNA or RNA nucleotide trigger sequence, associated detection systems, methods for detecting the DNA or RNA nucleotide trigger sequence as well as further proteins of interest and associated uses.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
30.
PARTICLE-STABILIZED FOAMS USING SUSTAINABLE MATERIALS
Described is a method of preparing foams, wherein a suspension comprising an aqueous liquid, particles and at least one surfactant is provided, wherein the at least one surfactant at least partially hydrophobizes a surface of the particles, and wherein the suspension comprising the particles having the at least partially hydrophobized surface is foamed. The at least one surfactant is selected from surfactants having a backbone chain comprising at least nine carbon atoms, the at least one surfactant preferably being an amphiphilic molecule consisting of a tail coupled to a head group, wherein the tail comprises the backbone chain comprising at least nine carbon atoms.
An arrangement for additive manufacturing of a structure, preferably an architectural structure, the arrangement comprising a nozzle having a construction material outlet configured to extrude construction material in the form of a hollow core bead along a manufacturing path defined by multiple points, a fluid outlet configured to inject a fluid into the hollow core of the extruded bead, a fluid pressure adjusting device configured to adjust a pressure of the fluid injected into the hollow core of the extruded bead via the fluid outlet, and a control unit configured to determine a pressure value assigned to a point of the manufacturing path and to control the fluid pressure adjusting device on the basis of the determined pressure value. Furthermore, a method for generating control data for such an arrangement is disclosed.
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
The invention relates to a ULK1 inhibitor for use in the treatment of a human or mammalian patient being diagnosed for, suffering from, or being at risk of developing a neurodegenerative disease, or in the prevention of such condition.
A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A steerable device includes an elongated element configured to be navigated through the mammalian body. The elongated element has a device tip configured for allowing steering of the elongated element by way of an external magnetic field. Further, the device tip includes a plurality of segments, each segment including a segment body and a segment interface, and a plurality of connectors, each connector including a connector body and a connector interface. The connector interfaces and the segment interfaces have each time mutually complementing shapes allowing rotational movements relative to each other and forming a connection to retain the connectors and the segments in a mated condition, and the magnetic elements form at least partially segment bodies or connector bodies or both.
A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
A61B 1/00 - Instruments pour procéder à l'examen médical de l'intérieur des cavités ou des conduits du corps par inspection visuelle ou photographique, p. ex. endoscopesDispositions pour l'éclairage dans ces instruments
The invention refers to an apparatus for powder-based additive manufacturing of three-dimensional structures on a platform (4). The apparatus comprises a powder delivery mechanism (100) with a first powder chamber (11) for a first powder with a first powder outlet, and a second powder chamber (12) for a second powder with a second powder outlet. In addition, the powder delivery mechanism (100) comprises a gating mechanism (3) with a first slot (31) and a second slot (32), wherein the powder delivery mechanism (100) and/or the platform (4) are rotatable around a platform center axis (10) of the platform (4), wherein the gating mechanism (3) is arranged such that the first slot (31) defines an outlet surface of the first powder outlet and the second slot (32) defines an outlet surface of the second powder outlet, wherein the gating mechanism (3) is displaceable relatively to the first powder outlet and/or the second powder outlet.
B22F 10/28 - Fusion sur lit de poudre, p. ex. fusion sélective par laser [FSL] ou fusion par faisceau d’électrons [EBM]
B22F 12/00 - Appareils ou dispositifs spécialement adaptés à la fabrication additiveMoyens auxiliaires pour la fabrication additiveCombinaisons d’appareils ou de dispositifs pour la fabrication additive avec d’autres appareils ou dispositifs de traitement ou de fabrication
B29C 64/153 - Procédés de fabrication additive n’utilisant que des matériaux solides utilisant des couches de poudre avec jonction sélective, p. ex. par frittage ou fusion laser sélectif
The present invention relates to a combination therapy against pathogenic bacteria in the gut, wherein a bacteriophage against the capsule of the pathogenic bacterium is combined with a vaccination against a bacterial antigen which is normally masked by the capsule.
The present invention relates to a method for screening engineered antibody Fc regions having modified Fc receptor binding properties, the method comprising the steps of: (a) providing a plurality of cells displaying engineered antibody Fc regions on their cell surface, preferably wherein each cell comprised in the plurality of cells displays an engineered antibody Fc region comprising at least one mutation; (b) contacting the cells in step (a) with an Fc receptor; (c) separating cells that have been contacted with the Fc receptor in step (b) into two or more cell populations according to their ability to bind to the Fc receptor, preferably wherein the ability of an engineered antibody Fc region to bind to the Fc receptor is determined by comparison with a reference antibody Fc region; and (d) sequencing cells from at least one of the populations obtained in step (c), preferably to identify mutations in the engineered antibody Fc region that (i) confer improved binding to the Fc receptor, (ii) do not affect binding to the Fc receptor, and/or (iii) confer reduced binding to the Fc receptor. Further provided herein are methods for predicting the Fc receptor binding properties of an engineered antibody Fc region, as well as methods for generating an engineered antibody Fc region having desired Fc receptor binding properties
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C40B 40/08 - Bibliothèques comprenant de l'ARN ou de l'ADN codant des protéines, p. ex. bibliothèques de gènes
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relates to a process for the stereoselective preparation of such compounds. The compound of formula (I) can be used as a medicament, in particular for inhibiting coronin 1 expression in the induction of immunosuppression or in the treatment and/or prevention of a disease or disorder selected from the group consisting of transplant rejection, autoimmune diseases, inflammatory diseases, infectious diseases, and lymphoproliferative disorders. The present invention further relates to a vector comprising a coronin 1 promoter element, wherein in a vertebrate genome, said coronin 1 promoter element starts directly upstream from a transcription starting site (TSS) of a coronin 1 gene and spans a sequence stretch of at least about 700 bp in said genome. The present invention further relates to a method using said vector for identifying immunomodulatory compounds that alter the coronin 1 promoter activity. The present invention further relates to BRD3 as an upstream target responsible for driving the coronin-1 expression and activity in immune cells, and relates to compounds, in particular compound of formula (I), that selectively target bromodomains of BRD3 and thereby deplete coronin 1 levels.
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, diastereoisomer, enantiomer, polymorph, racemic mixture, solvate or isomers and mixtures thereof. The invention further relates to a process for the stereoselective preparation of such compounds. The compound of formula (I) can be used as a medicament, in particular for inhibiting coronin 1 expression in the induction of immunosuppression or in the treatment and/or prevention of a disease or disorder selected from the group consisting of transplant rejection, autoimmune diseases, inflammatory diseases, infectious diseases, and lymphoproliferative disorders. The present invention further relates to a vector comprising a coronin 1 promoter element, wherein in a vertebrate genome, said coronin 1 promoter element starts directly upstream from a transcription starting site (TSS) of a coronin 1 gene and spans a sequence stretch of at least about 700 bp in said genome. The present invention further relates to a method using said vector for identifying immunomodulatory compounds that alter the coronin 1 promoter activity. The present invention further relates to BRD3 as an upstream target responsible for driving the coronin-1 expression and activity in immune cells, and relates to compounds, in particular compound of formula (I), that selectively target bromodomains of BRD3 and thereby deplete coronin 1 levels.
A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
C07D 215/54 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène liés en position 3
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
39.
COMPOUNDS COMPRISING NON-CANONICAL AMINO ACIDS AND USES THEREOF
Provided herein are compounds comprising an isopeptide-linked lysine or an analog thereof. Further provided herein are methods for engineering peptide-binding proteins having increased affinity and/or selectivity for the compound according to the invention, as well as peptide-binding proteins with increased selectivity for the compound according to the invention. Moreover, methods for incorporating non-canonical amino acids into proteins are provided herein.
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
40.
DEVICES AND METHODS FOR DETERMINING SPATIOTEMPORAL REFRACTIVE INDEX CHANGES
A measurement assembly for determining refractive index changes in a sample comprises a light source (2), a tunable wavelength selector (3), an image sensor (4), a processing unit (6), and a Fabry-Perot unit (5) comprising a first plane surface (51) and a second plane surface (52), the Fabry-Perot unit (5) having a sample reception space (53) arranged between the first plane surface (51) and the second plane surface (52) to receive a sample. The Fabry-Perot unit (5) is arranged to act as a wavelength-dependent light intensity filter. The image sensor (4) is configured to record a two-dimensional image of the sample reception space for different spectral subranges and the processing unit (6) is configured to reconstruct the intensity filter function of the Fabry-Perot unit (5) based on the recorded two-dimensional images, and to determine a refractive index map based on the reconstructed intensity filter function.
G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
A solar receiver having an enclosure delimiting a cavity that is configured to receive a heat transfer fluid, at least one opening in the enclosure for access of solar radiation into the cavity, at least one window that seals the opening, and at least one cooling device that is configured to cool the window. The cooling device is configured to supply at least one window-cooling liquid fluid to the window, such that the window-cooling liquid fluid forms at least one liquid layer on and/or in the window.
F24S 40/55 - Agencements pour le refroidissement, p. ex. en utilisant des moyens externes de dissipation de la chaleur ou par circuits de refroidissement internes
F24S 20/20 - Collecteurs de chaleur solaire pour recevoir de l’énergie solaire concentrée, p. ex. récepteurs pour centrales électriques solaires
F24S 80/50 - Couvertures transparentesÉléments transmettant les rayons solaires entrants et empêchant les rayonnements thermiques sortants
An apparatus for liquid handling, in particular of small liquid volumes, an associated method and use for liquid handling, in particular for receiving and/or dispensing a liquid, the apparatus comprising: a capillary; a plate; means for moving the capillary and/or the plate relative to each other; and a sensor (9).
A pupillometry system (100) for computer-implemented assessment of brain aging and presymptomatic Alzheimer's risk in cognitively unimpaired individuals through computer-human interaction with a user (5), wherein the pupillary moment-by-moment dynamics of the user on a sensory stimulation decision task with continuous or—at least two—discrete selection options and a subsequent reward/feedback choice is analyzed.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
A61B 3/11 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour mesurer la distance interpupillaire ou le diamètre de la pupille
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A connector assembly (100) for connecting external power sources to an implanted medical device has a distal driveline portion (102) and a proximal driveline portion (101), each comprising a plurality of isolated electricity wires (103) and at least one load carrying wire (104). An intermediate driveline assembly (300) is provided and adapted to arrange the electricity wires (103) and the load carrying wire(s) (104) in a flat plane (13) for a predetermined distance (11) in the longitudinal direction (10) of these wires (103, 104), wherein the electricity wires (103) and the load carrying wire(s) (104) are positioned in a spacing from each other over at least a part of this predetermined distance (11') in that plane (13).
A61M 60/178 - Pompes ou dispositifs de pompage implantables, c.-à-d. que le sang est pompé à l’intérieur du corps du patient implantables dans ou sur le cœur, ou autour du cœur prélevant le sang d’un ventricule et renvoyant le sang vers le système artériel par une canule externe au ventricule, p. ex. dispositifs d’assistance pour ventricule gauche ou droit
A61M 60/216 - Pompes pour le sang à déplacement non positif comportant un élément rotatif agissant sur le sang, p. ex. un impulseur
A61M 60/878 - Connexions électriques dans le corps du patient
The present invention relates to a device (1) for reducing a particle density of a sample of a suspension of particles in a liquid, the device comprising a measurement flow path (13) for characterizing the sample of the suspension, wherein the device (1) is configured to withdraw a sample of the suspension residing in a main vessel (100), and to dilute the sample, particularly when a measure indicative of the particle density in the sample is above a pre-defined threshold.
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie
G01N 15/075 - Recherche de la concentration des suspensions de particules par des moyens optiques
46.
A LIPID EMULSION FOR BRAIN REGENERATION AND OPTIMIZING BRAIN DEVELOPMENT VIA PARENTERAL OR ENTERAL ADMINISTRATION
The present invention relates to a specific lipid emulsion comprising ≥ 5 % stearidonic acid and ≥ 15 % α-linolenic acid for use in neuroprotection, neuroregeneration and neurodevelopment.
A61K 31/20 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique
A61K 31/201 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant une ou deux doubles liaisons, p. ex. acides oléique ou linoléique
A61K 31/202 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe carboxyle lié à une chaîne acyclique d'au moins sept atomes de carbone, p. ex. acides stéarique, palmitique ou arachidique ayant au moins trois doubles liaisons, p. ex. acide linolénique
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
47.
METHOD AND ASSEMBLY FOR DETERMINING A REPRESENTATION WHICH INDICATES THE ACTIVITY OF A LOCUS COERULEUS SYSTEM OF A USER
A computer implemented method for determining a representation which indicates the activity of a locus coeruleus system of a user. The method includes the steps of, measuring the size of a pupil of a user; providing a representation the appearance of which is based on the measured size of the pupil; and either, providing an audio stimulus designed to decrease or increase the activity of the user's locus coeruleus system when heard by the user, wherein the content of the audio stimulus is dependent on the measured size of the pupil of the user, or, providing a haptic stimulus designed to decrease or increase the activity of the user's locus coeruleus system when heard by the user. Characteristics of the haptic stimulus are dependent on the measured size of the pupil of the user. Also methods estimate the activity of a locus coeruleus system of a user.
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 3/11 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient pour mesurer la distance interpupillaire ou le diamètre de la pupille
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I)
A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I)
A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I)
and a second monomer of the general formula (II)
A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I)
and a second monomer of the general formula (II)
A copolymer and its use as coating whereby the copolymer comprises a first monomer of the general formula (I)
and a second monomer of the general formula (II)
wherein Y is selected from the group consisting of —CH2Z3, —NHCOR5, —CONHR6, —OCOR7, —COOR8 and —OR9, and where Z1, Z2, and Z3 are selected from the group consisting of fluoro, chloro, bromo, iodo, hydroxyl, toluene-4-sulfonyloxy and methylsulfonyloxy. R1, R2, R3 and R4 are independently from each other selected from the group consisting of linear or branched C1-C30 alkyl, a linear or branched C2-C30 alkenyl, a linear or branched C2-C30 alkynyl, sulfo, nitro, amino, hydroxy, oligo(C2 to C4-alkylene glycol), —NHCOR5, —CONHR6, —OCOR7, —COOR8 and —OR. R5, R6, R7, R8 and R9 are selected from the group consisting of a linear or branched C1-C30 alkyl, a linear or branched C2-C30 alkenyl and a linear or branched C2-C30 alkynyl.
C08G 61/10 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aromatiques, p. ex. polyphénylènes
The invention relates to a method, particularly a computer-implemented method for determining a fatigue value of a person, the method comprising the steps of:
i) displaying of:
a) a first group (1) of symbols and a second group (2) of symbols,
b) a selection rule (3) associating each of the symbols of the first group (1) of symbols to one symbol of the second group (2) of symbols,
ii) highlighting one symbol (11) of the first group (1) of symbols,
iii) receiving a user input from the person selecting one symbol (12) of the second group (2) of symbols,
iv) determining a truth value based on the selected symbol (12) of the second group (2) of symbols, wherein the truth value assumes a true value if the selected symbol (12) is selected in accordance with the selection rule (3) and wherein the truth value takes on a false value if not, wherein the highlighted symbol (11) of the first group (1) of symbols is highlighted for a predetermined time based on a statistical response time of the person, and wherein if the user input is not received within the predetermined time in step iv), the method is set forth with step v) having the truth value set to the false value, or the method is set forth with step vi),
v) storing the truth value on a non-transitory memory device,
vi) changing the selection rule (3), such that each of the symbols of the first group (1) of symbols is associated anew to one symbol of the second group (2) of symbols,
vii) changing the highlighted symbol (11) of the first group (1) of symbols,
viii) repeating steps iii) to vii) at least once and
ix) based on at least some of the stored truth values, determining a fatigue value of the person.
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
50.
METHOD AND SETUP FOR CHANGING AN INTER-PARTICLE DISTANCE
A method for changing an inter-particle distance (D) between particles (1) arranged in a particle array (2) is provided, the method comprises creating a primary optical lattice (10), loading the particles (1) into the primary optical lattice (10) such that the particles (1) are trapped in the primary optical lattice (10), changing a primary-lattice spacing (L1) of the primary optical lattice (10) to change the inter-particle distance (D), creating an auxiliary optical lattice (20), ramping up the auxiliary-lattice and ramping down the primary optical lattice until the particles (1) are trapped in the auxiliary optical lattice (20), setting the primary-lattice spacing (L1) to a different primary-lattice spacing value, ramping up the primary-lattice and ramping down the auxiliary lattice (20) until the particles are trapped in the primary optical lattice (10) again.
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
51.
ASSAY DEVICE FOR ELECTROCHEMICAL SENSING OF A SAMPLE FLUID
An assay device (1) for electrochemical sensing of a sample fluid comprises, at least one substrate (2), at least one electrode (3), and at least one channel (5). The channel (5) extends at least partially in the substrate (2) and is configured to receive the sample fluid. At least part of the electrode (3) is arranged in the channel (5) and is configured to detect at least one electrical property being associated with the sample fluid. The substrate (2), at least in the region of the channel (5), is porous. At least the part of the electrode (3) being arranged in the channel (5) is porous. The substrate (2) is configured to exert a capillary force onto the sample fluid in the channel (5) such that the sample fluid is flowing through the part of the electrode (3) being arranged in the channel (5).
The present invention relates to an expression system and a method ensuring constant-level concentration of an output. The invention also relates to a cell comprising the expression system.
C12N 15/67 - Méthodes générales pour favoriser l'expression
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
54.
SYSTEMS AND REACTORS FOR THE PRODUCTION OF AMMONIA
The present invention relates to systems and reactors for continuous production of ammonia. The systems are particularly suited to produce ammonia in decentralized, rural locations using temporal surplus electricity from renewable sources, thereby allowing the production of fertilizers in the location of need.
B01J 8/02 - Procédés chimiques ou physiques en général, conduits en présence de fluides et de particules solidesAppareillage pour de tels procédés avec des particules immobiles, p. ex. dans des lits fixes
The invention pertains to a method for controlling a reaction of a CRISPR Cas effector protein with a target, an associated CRISPR Cas effector protein and associated uses for detection, optionally detection of a nucleic acid in a biological sample or in a sample derived from a biological material.
The present invention relates to a method for dechlorinating chlorinated organic compounds in an electrochemical device comprising an undivided electrolytic cell with two electrodes acting as anode and cathode, by a) providing a composition comprising the chlorinated organic compounds, a solvent and a sacrificial electron donor, wherein the solvent can also function as the sacrificial electron donor, or alternatively, the solvent and the sacrificial electron donor are two separate components, and b) conducting an electrochemical reaction to dechlorinate the chlorinated organic compounds, characterized by alternating the polarity of the two electrodes, with both electrodes being graphite electrodes.
C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
C02F 1/467 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par désinfection électrochimique
C02F 1/68 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par addition de substances spécifiées, pour améliorer l'eau potable, p. ex. par addition d'oligo-éléments
C02F 101/36 - Composés organiques contenant des atomes d'halogène
The invention relates to a method for making a micro-structured hydrogel, comprising the steps of: providing a hydrogel composition comprising a polymer crosslinked by linker moieties comprising a photolabile coumarin moiety, and subjecting the hydrogel composition to structured irradiation with light having a wavelength of ≥700 nm. The invention also relates to a micro-structured hydrogel composition, comprising a hydrogel crosslinked by moieties comprising a photolabile moiety susceptible to cleavage by two-photon irradiation of a wavelength of ≥700 nm, and channels or cavities having a diameter of ≤10 µm. In some embodiments, the hydrogel comprises a plurality of ellipsoid indentations (lacunae) on its surface, and a plurality of channels (canaliculi) departing from each lacuna.
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
C08J 3/28 - Traitement par ondes énergétiques ou par rayonnement de particules
C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
C07D 311/08 - Benzo [b] pyrannes non hydrogénés dans le carbocycle avec des atomes d'oxygène ou de soufre liés directement en position 2 non hydrogénés dans l'hétérocycle
C08G 65/48 - Polymères modifiés par post-traitement chimique
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
58.
GYROTRON SYSTEM COMPRISING INTEGRATED SUPERCONDUCTING MAGNET AND CAVITY
A gyrotron system (1) comprises a housing (2), an electron gun (3) configured to produce an electron beam, at least one magnet (4) configured to produce a magnetic field, and a cavity (5) configured to receive the electron beam, and wherein microwaves and/or Terahertz waves (16) are generatable in the cavity (5) by a resonance coupling between the electron beam and the magnetic field produced by the magnet (4). The magnet (4) is a superconducting magnet that is configured to exhibit superconductivity upon cooling below its critical temperature and that is arranged around the cavity (5), and the cavity (5) and the superconducting magnet (4) are arranged within the housing (2).
H01J 25/02 - Tubes à faisceau électronique modulé en vitesse ou en densité dans une zone modulatrice et cédant ensuite de l'énergie dans une zone inductrice, les zones étant associées à un ou plusieurs résonateurs
59.
AMMONIA CONCENTRATION DETECTION METHOD FOR AN INTERNAL COMBUSTION ENGINE
Method for calculating NH3 and NOx concentrations downstream from an SCR system of an internal combustion engine (E) of a vehicle by means of a statistical module, the method comprising the following steps: using temperature measurements acquired upstream (T1) and downstream (T2) of the Selective Reduction Catalyst (SCR) as first input variables and NOx mass flow measurements acquired upstream (N1) and downstream (N2) of the SCR as second input variables; calculating an NH3 concentration downstream from the SCR catalytic converter as a function of the first and second inputs.
A method of producing a deposition structure (1) on a substrate (2) comprises the steps of i) providing at least one depositor (3) for depositing at least one material (6), ii) providing at least one mask (4) comprising a plurality of apertures (5, 5a,...), iii) providing at least one substrate (2), and iv) depositing at least one material (6) from the depositor (3). Part of the material (6) passes through the apertures (5, 5a,...) of the mask (4) and is deposited on a surface (7) of the substrate (2), whereby at least one deposition structure (1) is formed on the surface (7) of the substrate (2). At least one tilting angle (φ) between i) the substrate (2) and/or the mask (4) and ii) the depositor (3) is at least temporarily changed before and/or during the deposition of the material (6). Additionally or alternatively, at least one rotating angle (θ) between i) the substrate (2) and/or the mask (4) and ii) the depositor (3) is at least temporarily changed before and/or during the deposition of the material (6).
C23C 14/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
C23C 14/22 - Revêtement par évaporation sous vide, pulvérisation cathodique ou implantation d'ions du matériau composant le revêtement caractérisé par le procédé de revêtement
C23C 14/52 - Dispositifs pour observer le processus de revêtement
C23C 14/54 - Commande ou régulation du processus de revêtement
H01L 21/308 - Traitement chimique ou électrique, p. ex. gravure électrolytique en utilisant des masques
H05B 33/10 - Appareils ou procédés spécialement adaptés à la fabrication des sources lumineuses électroluminescentes
H10K 71/16 - Dépôt d'une matière active organique en utilisant un dépôt physique en phase vapeur [PVD], p. ex. un dépôt sous vide ou une pulvérisation cathodique
G03F 9/00 - Mise en registre ou positionnement d'originaux, de masques, de trames, de feuilles photographiques, de surfaces texturées, p. ex. automatique
B82Y 40/00 - Fabrication ou traitement des nanostructures
09 - Appareils et instruments scientifiques et électriques
38 - Services de télécommunications
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, research, navigation, surveying, photographic,
cinematographic, audiovisual, optical, weighing, measuring,
signaling, detecting, testing, inspecting, life-saving and
teaching apparatus and instruments; apparatus and
instruments for conducting, switching, transforming,
accumulating, regulating or controlling electricity
distribution or use; apparatus and instruments for sound,
image or data recording, transmission, reproduction or
processing; recorded and downloadable media, software, blank
digital or analog recording and storage media; computers and
computer peripheral devices; software for computers; web
application software; recorded and downloadable computer
programs and computer software enabling common use and
collaborative development of computer software, computer
code and user-created content; recorded and downloadable
data, namely weightings, parameters and meta-parameters of
artificial intelligence models; recorded and downloadable
data, namely weightings, parameters and meta-parameters of
artificial intelligence models for creating, recognizing,
translating, processing, understanding, generating and
analyzing languages and monolingual and multilingual human
texts; recorded and downloadable computer programs and
recorded and downloadable computer software for artificially
creating, recognizing, translating, processing,
understanding, generating and analyzing languages and
monolingual and multilingual human texts; recorded and
downloadable pretrained data, namely, neural network
weightings, parameters and meta-parameters for large
language models for automatically creating, recognizing,
translating, processing, understanding, generating and
analyzing spoken language, texts and language; downloadable
computer programs and downloadable computer software for
simulating conversations. Telecommunications; providing access to websites, platforms,
portals, databases, computer programs, web applications and
data via computer or data networks or using information
technology and telecommunication networks; transmitting,
broadcasting and receiving audio, video content, still and
moving images, text and data via computer or data networks
or using information technology and telecommunication
networks; transmitting web applications via the Internet;
rental and provision of free access time to global computer
networks and databases. Teaching; training; provision of entertainment; cultural
activities. Scientific and technological services as well as research
and design services relating thereto; industrial analysis,
industrial research and industrial design services; quality
control and authentication services; design and development
of computer hardware and software; software engineering;
research and development in the field of artificial
intelligence; technical advisory services in the field of
artificial intelligence; design of computer-simulated
models; developing web applications; providing
non-downloadable web applications; developing computer
programs and computer software for common use and
collaborative development of computer software, computer
code and user-created content; providing computer programs
and non-downloadable computer software enabling common use
and collaborative development of computer software, computer
code and user-created content; information technology
services, namely development of weightings, parameters and
meta-parameters for artificial intelligence models;
providing software for developing weightings, parameters and
meta-parameters for artificial intelligence models;
providing non-downloadable weightings, parameters and
meta-parameters for developing artificial intelligence
models (information technology services); information
technology services, namely developing weightings,
parameters and meta-parameters for artificial intelligence
models for creating, recognizing, translating, processing,
understanding, generating and analyzing languages and
monolingual and multilingual human texts; providing software
for developing weightings, parameters and meta-parameters
for artificial intelligence models for creating,
recognizing, translating, processing, understanding,
generating and analyzing languages and monolingual and
multilingual human texts; providing non-downloadable
weightings, parameters and meta-parameters for developing
artificial intelligence models for creating, recognizing,
translating, processing, understanding, generating and
analyzing languages and monolingual and multilingual human
texts (information technology services); developing computer
programs and computer software for artificially creating,
recognizing, translating, processing, understanding,
generating and analyzing languages and monolingual and
multilingual human texts; providing computer programs and
non-downloadable computer software for artificially
creating, recognizing, translating, processing,
understanding, generating and analyzing languages and
monolingual and multilingual human texts; information
technology services, namely developing pretrained neural
network weightings, parameters and meta-parameters for large
language models for automatically creating, recognizing,
translating, processing, understanding, generating and
analyzing spoken language, text and language; providing
software for the development of pretrained weightings,
parameters and meta-parameters of neural networks for large
language models for automatically creating, recognizing,
translating, processing, understanding, generating and
analyzing spoken language, text and language; providing
non-downloadable pretrained neural network weightings,
parameters and meta-parameters for large language models for
automatically creating, recognizing, translating,
processing, understanding, generating and analyzing spoken
language, text and language (information technology
services); developing computer programs and conversations;
providing non-downloadable computer software for simulating
non-downloadable computer programs and downloadable computer
software for simulating conversations; developing artificial
intelligence models and artificial intelligence software for
creating, recognizing, translating, processing,
understanding, generating and analyzing languages and
monolingual and multilingual human texts; customizing free
open source software; hosting and maintenance of platforms,
web applications and websites; hosting and maintaining
websites and platforms for third parties for common software
development; hosting and maintenance of websites and
platforms for virtual collaboration.
The present invention is directed to a method for preparing 3-dimensional vascular models comprising the 3-dimensional imaging, printing and embedding of 3-dimensional vasculature and subsequent selective dissolution of the printed and embedded 3-dimensional vasculature in the 3-dimensional material. Furthermore, the present invention relates to the 3-dimensional vascular model prepared by the inventive method as well as to methods for the in vitro practice of a surgical method in an animal or human and a method for a surgical intervention in the vasculature of an animal or human in need thereof.
The present invention relates to a cell line wherein the endogenous class I and/or class II HLA alleles are inactivated, the cell line further comprising (a) a polynucleotide encoding a first fluorescent marker under control of at least one STAT response element, and (b) an interleukin 2 (IL-2) receptor. The invention further relates to the use of said cell line for the identification of antigenic peptide and/or the identification of alloreactive T cell receptors.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C07K 14/715 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des cytokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des lymphokinesRécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des interférons
C12Q 1/6881 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour le typage de tissu ou de cellule, p. ex. sondes d’antigène leucocytaire humain [HLA]
A method of manufacturing a jointless superconducting multi-coil (1, 1') comprises the steps of providing a superconducting element (2) and winding a first part (2b1) around at least part of a first mandrel (3) so as to form a first pre-coil (4) of a first coil (5), winding at least part around at least part of the first mandrel (3) so as to form the first coil (5), and i) winding a second part (2b2) around at least part of a second mandrel (6) so as to form a second pre-coil (7) of a second coil (8) and winding at least part around at least part of the second mandrel (6) so as to form the second coil (8), or ii) winding a second part (2b2) around at least part of the first mandrel (3) so as to form a second pre-coil (7') of a second coil (8') and winding at least part around at least part of the first mandrel (3) so as to form the second coil (8'). The multi-coil (1, 1') comprises the first coil (5) and the second coil (8, 8') being arranged above one another with respect to a longitudinal direction (Lc, Lc') of the multi-coil (1, 1').
H01F 41/04 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants pour la fabrication de bobines
H01F 6/06 - Bobines, p. ex. dispositions pour l'enroulement, l'isolation, les enveloppes ou les bornes des bobines
A material for storing thermal energy comprises or consists of a crosslinked polymer, wherein the crosslinked polymer comprises backbone chains, crosslinking chains, and side chains. The crosslinking chains link the backbone chains to one another. The side chains are attached to one site of the backbone chains. The side chains comprise a phase-change moiety, and wherein the phase-change moiety is configured to change between a first solid state and a second solid state.
C09K 5/06 - Substances qui subissent un changement d'état physique lors de leur utilisation le changement d'état se faisant par passage de l'état liquide à l'état solide, ou vice versa
C09K 5/14 - Substances solides, p. ex. pulvérulentes ou granuleuses
A granular hydrogel composition, preferably for the treatment of wounds, comprising a mixture of at least a plurality of first hydrogel microspheres, wherein the first hydrogel microspheres are formed of a first hydrogel scaffold material, and wherein the first hydrogel microspheres further comprise at least one growth factor compound, and at least a plurality of second hydrogel microspheres, wherein the second hydrogel microspheres are formed of a second hydrogel scaffold material, and wherein the second hydrogel microspheres further comprise at least a capturing compound for capturing a proinflammatory compound, wherein the capturing compound is bound to the second hydrogel scaffold material, and optionally a liquid aqueous phase.
A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
67.
Method and Microfluidic Device for Studying Cell Deformations
In a method of investigating cell deformations, a sample fluid including cells suspended in a suspending medium is provided. A flow of the sample fluid through a focusing microchannel is established. The suspending medium is a non-Newtonian fluid having viscoelastic properties such that cells that enter the focusing microchannel are focused towards a center of the focusing microchannel due to the viscoelastic properties of the suspending medium, causing the cells to exit the focusing microchannel in single file. Subsequently, the sample fluid that has exited the focusing microchannel is caused to flow through a deformation microchannel arranged downstream of the focusing microchannel to cause a deformation of cells that have exited the focusing microchannel and have entered the deformation microchannel, the deformation being caused by a flow pattern created by interaction of the fluid flow with the deformation microchannel.
Friedrich-Alexander-Universität Erlangen-Nürnberg in Vertretung des Freistaates Bayem (Allemagne)
National Chung Hsing University (Taïwan, Province de Chine)
Inventeur(s)
Neuhaus, Ekkehard
Bellin, Leo
Sonnewald, Uwe
Zierer, Wolfgang
Gruissem, Wilhelm
Abrégé
The present disclosure relates to genetically modified plants including a modified POTASSIUM TRANSPORTER 2 (AKT2) protein or an overexpressed AKT2 protein. The present disclosure further relates to methods of producing genetically modified plants including the modified AKT2 protein or the overexpressed AKT2 protein. In addition, the present disclosure relates to genetically modified plants with improved photosynthesis, higher rate of CO2 fixation and/or electron transport rate, improved yield under different growing conditions, and improved storage root or tuber growth.
NATIONAL CHUNG HSING UNIVERSITY (Taïwan, Province de Chine)
Inventeur(s)
Neuhaus, Ekkehard
Bellin, Leo
Sonnewald, Uwe
Zierer, Wolfgang
Gruissem, Wilhelm
Abrégé
The present disclosure relates to genetically modified plants including a modified POTASSIUM TRANSPORTER 2 (AKT2) protein or an overexpressed AKT2 protein. The present disclosure further relates to methods of producing genetically modified plants including the modified AKT2 protein or the overexpressed AKT2 protein. In addition, the present disclosure relates to genetically modified plants with improved phloem transport, improved photosynthesis, higher rate of CO2 fixation and/or electron transport rate, increased yield under different growing conditions, and increased storage root or tuber growth.
An arrangement (1) for inserting an implant device (2) into biological tissue (4) comprises at least one implant device (2), and at least one insertion device (3). The insertion device (3) is configured to penetrate biological tissue (4). The implant device (2) and the insertion device (3) are configured to couple to one another via an implant-insertion coupling. The implant device (2), when being coupled to the insertion device (3) via the implant-insertion coupling, is insertable into the biological tissue (4) via the insertion device (3). The implant device (2) comprises at least one bundle (5) of fibers (6, 6a, …), and wherein the fibers (6, 6a, …) are coupled to one another via a fiber-fiber coupling, the implant-insertion coupling being different from the fiber-fiber coupling.
A61B 5/291 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG]
A61B 5/293 - Électrodes bioélectriques à cet effet spécialement adaptées à des utilisations particulières pour l’électroencéphalographie [EEG] invasives
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A motion generation system includes a tracking model, executed by a processor, configured to track at least one kinematic reference motion of a robotic device; a reward surrogate model, executed by the processor, that evaluates a performance of the tracking model with respect to the at least one kinematic reference motion and estimates at least one reward for the tracking model based on the performance; and a generative model, executed by the processor, configured to generate a motion for the robotic device based on a contextual input and the estimated at least one reward, wherein the generative model is trained with a pre-training operation and a refinement operation separate from the pre-training operation.
The present invention relates to a method for the determination of cleavage sites in genomic DNA caused by exposure to one or more site directed nucleases ("SDN") directed against one or more genomic target sequences (Fig. 7).
A steerable device for use inside of a mammalian body, including an elongated element and a flexible device tip which includes a tubular section and a plurality of permanent magnetic elements disposed in the tubular section. Each magnetic element has an axial bore and the axial bores form an axial conduit in which a core wire extends. The axial bore extends from a first to a second axial end of the magnetic element opposed to the first axial end. First axial ends and second axial ends have a bevel allowing movement of the magnetic elements against one another, wherein the bevel of axial ends of adjacent magnetic elements is rounded with a different radius or flat with a different angle to the longitudinal axis to control bending of the device tip.
222 concentration changes, wherein the sensor comprises: two electrodes; and a sensing composite arranged between the two electrodes; wherein the sensing composite comprises: one or more carbon-based nanostructures having an outer surface; one or more metal-oxides functionalized to the outer surface of the one or more carbon-based nanostructures; and one or more photosensitizer capable of harvesting visible light, thereby inducing a photoconductance change in the underlying metal-oxide functionalized to the one or more carbon-based nanostructure, wherein said photosensitizers are functionalized to the outer surface of the one or more carbon-based nanostructures and/or the one or more metal-oxides.
G01N 27/12 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de l'absorption d'un fluideRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance d'un corps solide dépendant de la réaction avec un fluide
75.
TRANSCRIPTIONALLY RECORDING CELL COMPOSITION AND METHOD FOR NON-INVASIVE ASSESSMENT OF GUT FUNCTION
The invention relates to a bacterial cell comprising a Cas1 RT fusion protein, a Cas2 protein and a CRISPR direct repeat (DR) sequence, wherein an RNA polymerase promoter in addition to the leader sequence is associated with the DR sequence. The invention further relates to a composition comprising two bacterial cell populations, each comprising a Cas1 RT fusion protein and Cas2 protein. The two cell types contain different versions of a CRISPR direct repeat (DR) sequence. The invention further relates to methods for analysis of transcription recording events of bacteria having passed through a subject's intestine, to assign a probability to the subject having a condition, such as malnutrition or inflammation of the intestine.
C12Q 1/6897 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques faisant intervenir des gènes rapporteurs liés de façon fonctionnelle à des promoteurs
A CRISPR-based genome editing is disclosed. More specifically, nucleic acids, compositions and kits for editing a human HBD gene and their use in the treatment of haemoglobinopathies are disclosed. Methods of making thereof and methods of editing a human HBD gene are also disclosed. The composition and/or kit contains (a) a first component selected from a guide RNA (gRNA) or a DNA polynucleotide encoding the gRNA, (b) a second component selected from a DNA donor template or a vector containing the DNA donor template, and (c) a third component containing a Cas9 polypeptide or a variant thereof or a nucleic acid encoding a Cas9 polypeptide or a variant thereof.
The present invention relates to a hydrogel that can be used to prevent or treat endometriosis and as mechanical contraception. Said hydrogel comprises a crosslinked network of at least
a) a first monomer unit selected from the group consisting of acrylamide-2-methylpropanesulfonic acid (AMPS), acrylic acid, sodium acrylate, polyethylene glycol acrylate, (acrylamidopropyl)trimethylammonium chloride, methacrylic acid, 2-(dimethylamino)ethyl acrylate, 2-aminoethyl acrylate hydrochloride and 2-acryloxyethyltrimethylammonium chloride or a mixture thereof,
b) a second monomer unit selected from the group consisting of N-2-hydroxyethyl acrylamide (NHEA), N-2-hydroxypropyl acrylamide (NHPA), acrylamide, N-isopropylacrylamide (NIPAm), hydroxyethyl methacrylate (HEMA), hydroxyethyl acrylate (HEA), methyl acrylate, butyl acrylate, ethyl hexyl acrylate, methacrylamide, and ethyl hexyl (meth)acrylate or a mixture thereof,
c) at least one crosslinker with dual functionality, having at least two crosslinking groups and at least one degradable moiety selected from the group consisting of a photo-labile group, a disulfide bond and a diselenide bond.
Described is an exoskeleton device for assisted movement of a body member. The exoskeleton is for assisted movement of a member comprising a plurality of joints. The exoskeleton includes a first rigid section and a second rigid section positioned at respectively opposite ends of the member and an intermediate rigid section between the first and second rigid sections and positioned between the joints in the member. The exoskeleton also includes a repeating M structure comprising a plurality of length segments, each length segment extending between a respective pair of said rigid sections, and a drive spring extending at least from the first rigid section to the second rigid section, along an external region of the repeating M-structure, the drive spring between extendable and retractable to actuate the exoskeleton. A stiffness of each length segment is selected based on an amount of force to be applied to the member.
A filter assembly (1) for filtering a sample from a fluid (F) comprises a filter holder (4), a filter membrane (5), and a filter housing (6). The filter holder (4) is at least partially received in the filter housing (6), and the filter membrane (5) is attached to the filter holder (4) and is configured to filter a sample from a fluid (F) flowing from an inlet port (2) to an outlet port (3) through the filter membrane (5). The filter holder (4) is removably attached to the filter housing (6) such, that the filter holder (4) together with the filter membrane (5) is removable from the filter housing (6) and is insertable into a storage assembly (100) comprising a storage housing (20).
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
îîiîνν, the phase angle of the virtual internal voltage (formula (IV)) is controlled to match with the phase angle reference of the voltage reference (formula (I)) and the magnitude of the virtual internal voltage (formula (IV)) is adaptively changed depending on overcurrent conditions.
Catalyst assisted chemical etching of semiconductor substrate can achieve extreme aspect ratio (better than 1000:1), reproducibility and controlled etching quality for submicron feature size in the direction perpendicular to the substrate. The current patterning methods of the catalyst layer suffer of carbon contamination that affects the etching quality and limits the high-resolution pattern transfer in the semiconductor substrate for high aspect ratio etching. The present method allows to use semiconductor standard manufacturing processes to realize carbon-free pattern of catalyst layer by a physical separation with an interlayer material between the catalyst and the polymeric resist used in common lithographic methods. The present method allows to realize controlled predefined nanostructures with high resolution, high fidelity and high throughput yield during the catalyst assisted chemical etching of silicon for X-ray optics nanofabrication.
A method for designing a custom-made intra-oral appliance includes obtaining a virtual 3D reconstruction of an oral cavity, identifying an appliance region, obtaining a 3D appliance mesh from the appliance region, and processing the 3D appliance mesh for obtaining a volumetric appliance mesh. A method for obtaining a virtual 3D reconstruction of an oral cavity, the virtual 3D reconstruction being suitable for use in designing custom-made intra-oral appliances, and a method for designing an intra-oral appliance. The method for obtaining a virtual 3D reconstruction of an oral cavity includes obtaining at least one 2D image of an oral cavity, wherein the at least one image is acquired by a consumer electronics product, transforming the obtained at least one 2D image into an initial virtual 3D reconstruction of the oral cavity, and transferring information included in a further virtual 3D reconstruction to the initial virtual 3D reconstruction.
A61C 7/00 - Orthodontie, c.-à-d. obtention ou maintien de la position désirée des dents, p. ex. par redressage, nivellement, ajustement, séparation, ou par correction des malocclusions
A61C 7/08 - Appareils de contention du type épousant la forme de la bouche
G06F 30/12 - CAO géométrique caractérisée par des moyens d’entrée spécialement adaptés à la CAO, p. ex. interfaces utilisateur graphiques [UIG] spécialement adaptées à la CAO
The present disclosure relates to a beamlet diffraction fringe generation method for attenuation, differential phase-contrast and dark-field imaging. By generating a fringe through structured diffraction beamlet arrays (Fig. 10) from structured diffraction beamlet array optics (10), an intensity variation is induced by superposition. As this effect does not rely on Talbot-carpet orders, it provides a tool for arbitrary fringe geometry and size generation at any distance.
The present invention relates to a highly efficient process for the photo-initiated depolymerization of vinyl polymers in the presence of at least one chlorine-containing reagent, preferably at elevated temperatures. The invention further relates to the recycling of vinyl polymers comprising the process according to the invention as well as the use of chlorine-containing reagents for the depolymerization of vinyl polymers.
C08J 11/20 - Récupération ou traitement des résidus des polymères par coupure des chaînes moléculaires des polymères ou rupture des liaisons de réticulation par voie chimique, p. ex. dévulcanisation par traitement avec une substance organique par traitement avec des hydrocarbures ou des hydrocarbures halogénés
86.
A METHOD FOR DEFATTENING A STEATOTIC LIVER EX VIVO BY PERFUSION USING A PI4KB INHIBITOR
The present invention relates to a method for defattening a steatotic liver ex vivo, the method comprising perfusing a steatotic liver graft in a perfusion step using a perfusate comprising a PI4KB inhibitor as specified or a pharmaceutically acceptable salt or solvate thereof.
The present invention relates to a method for defattening a steatotic liver ex vivo, the method comprising perfusing a steatotic liver graft in a perfusion step using a perfusate comprising a PI4KB inhibitor as specified or a pharmaceutically acceptable salt or solvate thereof.
A61K 31/4985 - Pyrazines ou pipérazines condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A01N 1/126 - Agents physiologiquement actifs, p. ex. antioxydants ou nutriments
88.
MEDICAL DEVICE FOR USE AS URETERAL STENT, BILIARY STENT OR URINARY CATHETER IN A HUMAN OR ANIMAL BODY, MEDICAL SYSTEM COMPRISING SUCH A DEVICE AND METHOD OF ACOUSTICALLY ACTIVATING SUCH A DEVICE
The present invention relates to a medical device (100) for use as a ureteral stent, a biliary stent or a urinary catheter in a human or animal body. The medical device (100) comprises a hollow device body (101) having at least one body lumen (102), an inner body surface (105) and an outer body surface (106), wherein the inner body surface (105) delimits the at least one body lumen (102). The medical device (100) further comprises at least one array (110) of microstructures (111) located on the inner body surface (105) and/or the outer body surface (106) and configured to locally increase fluid-induced shear stress acting on the device body (101) in use of the medical device (100) in response to applying an acoustic field to the medical device (100). The invention further relates to a medical system comprising such as a medical device and an activation device configured to be positioned externally of a human or animal body, wherein the activation device comprises at least one sound transducer configured to generate an acoustic field for application from externally of the human or animal body to the medical device. The invention further relates to as to a method of acoustically activating such a medical device during use in a human or animal body, in particular for cleaning purposes and/or mass transport.
A laser distance ranging method includes splitting two combs of dual comb radiation into a signal radiation portion and a local oscillator radiation portion. The signal radiation portions are, after separation, combined into a combined signal radiation and directed onto an object, the distance to which is to be measured. The signal thrown back from the object is split into a first and second signal portions. The first signal portion is superimposed with the second local oscillator radiation portion to generate a first measurement signal, and the second signal portion is superimposed with the first local oscillator radiation portion to generate a second measurement signal. The distance to the object is determined from the first and second measurement signals, and from reference signals obtained by the partial reflection, wherein the Vernier effect can be used to extend ambiguity by comparison of the first and second measurement signals.
G01S 17/10 - Systèmes déterminant les données relatives à la position d'une cible pour mesurer la distance uniquement utilisant la transmission d'ondes à modulation d'impulsion interrompues
G01S 7/481 - Caractéristiques de structure, p. ex. agencements d'éléments optiques
The invention relates to a device designed to measure and/or influence a property of a body fluid, in particular cerebrospinal fluid, provided in a fluidics module of the device. The device comprises the fluidic module, a reusable base part for receiving the fluidic module, a connecting tube or a tube coupling designed to connect the device to a body fluid source, in particular a patient, such that the body fluid can be guided through the connecting tube or the tube coupling into the fluidic module of the device, and a microfluidic chip arranged on or in the fluidic module and designed to influence the property of the body fluid.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 5/15 - Dispositifs de prélèvement d'échantillons de sang
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
91.
TRAVELING WAVE PARAMETRIC AMPLIFIER AND MANUFACTURING METHOD, A METHOD FOR AMPLIFYING A TARGET SIGNAL, COMPUTER PROGRAM AND COMPUTER-READABLE DATA CARRIER
The invention relates to a traveling wave parametric amplifier (TWPA) for amplifying a target signal. The TWPA comprises a nonlinear transmission line (T1, T2) for receiving and propagating the target signal. The TWPA also comprises a plurality of coupling elements (DC1, DC2), wherein the plurality of coupling elements (DC1, DC2) are arranged at a distance from one another along the nonlinear transmission line (T1, T2). Each coupling element of the plurality of coupling elements (DC1, DC2) is configured to couple a pump signal portion from a pump feed line (D1) into the nonlinear transmission line (T1, T2), wherein the coupled-in pump signal portions form a total pump signal co-propagating in the nonlinear transmission line (T1, T2) in the same direction as the target signal for amplifying the target signal.
A process for screening a plasmid library encoding for peptides for one or more peptides that functionally activate a G protein-coupled receptor in a cell, by contacting the peptides with a cell expressing a G protein-coupled receptor, which functions as a sensor, and isolating the cells that functionally activate a G protein-coupled receptor to determine the sequence encoding the peptides.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12P 21/00 - Préparation de peptides ou de protéines
C40B 40/06 - Bibliothèques comprenant des nucléotides ou des polynucléotides ou leurs dérivés
A ring cavity laser (10) based on a semiconductor gain medium providing a lasing transition between quantised energy bands. The laser's ring cavity (12) possesses a plurality of modes, at least one of which having a frequency around which sufficient gain can be generated to cause lasing action. An electrical driver circuit applies an injection current to the semiconductor gain medium to cause population inversion and lasing action. A modulator (18) provides phase modulation within the cavity optical path at a modulation frequency near- resonant with an integer multiple or fraction of one of the mode frequencies. The phase modulation causes the laser to output a stable optical frequency comb which is established by random quantum walk in a photonic lattice created by said mode and its neighbouring resonator modes. A random quantum walk arises when these modes are coupled by the phase modulation.
H01S 5/065 - Accrochage de modesSuppression de modesSélection de modes
H01S 5/062 - Dispositions pour commander les paramètres de sortie du laser, p. ex. en agissant sur le milieu actif en faisant varier le potentiel des électrodes
H01S 5/10 - Structure ou forme du résonateur optique
H01S 5/34 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH]
94.
MICROFLUIDIC DEVICE AND METHOD FOR DETECTION OF BIOBURDEN
A microfluidic device comprises a flow channel (10) defining a flow direction (F), an array (20) of pillars (23) arranged in the flow channel (10), the array (20) comprising a supporting row (21) of pillars, the pillars of the supporting row (21) being separated by supporting row gaps (24) having a supporting row gap width (), and a membrane (30) comprising colloidal particles which are packed against the supporting row. At least some of the colloidal particles are larger than the supporting row gap width. Also disclosed is a method of manufacturing the device and a method of detecting bioburden using the device.
The novel invention is based, at least in part. on the surprising finding that the combination of bacterial strains comprising P. freudenreichii JS27 and B. longum subsp. infantis, particularly B. longum subsp. infantis TPY12-1 can be used in medicine and/or as a food supplement when grown simultaneously. As such and as shown in the description and appended examples, growth and viability of bacterial strains possessing synergistic behavior can be enhanced in the human gut and thus can increase bioavailability as compared with alternative combinations of bacteria.
The invention relates to a method for assessing corrosion phenomena on at least one metal element (1), wherein an electrode (5) is in electrically conductive connection with an electrolyte volume (4) positioned outside a metal element (1) or a material (3) that is electrolytically conductive or can be made electrolytically conductive and that is at least partially covering the metal element (1), and wherein the electrolyte volume (4) is brought into electrically conductive contact with the metal element (1) or the material (3) via a stream (10) of electrolyte, and wherein an electrochemical measurement indicative of a state of corrosion on the metal element (1) is carried out. The invention further relates to a device (11) and a system (100) for assessing corrosion phenomena on at least one metal element (1).
A spectrometer assembly (1) for determining spectral information about incoming electromagnetic radiation (F) comprises a radiation conversion element (2) that comprises a non-centrosymmetric material to frequency-double at least a portion of the incoming electromagnetic radiation (F) as the incoming electromagnetic radiation (F) propagates through the radiation conversion element (2). The radiation conversion element (2) exhibits a spatially inhomogeneous structure such that the frequency-doubled electromagnetic radiation (SH) comprises components propagating in a plurality of different directions. The spectrometer assembly further comprises a detection unit (3) which is configured to record a spatial speckle image that is generated by spatial interference of the components of the frequency-doubled electromagnetic radiation (SH) with each other, and a computing unit (4) which is configured to retrieve spectral information about the electromagnetic radiation (F) based on said spatial speckle image.
A transceiver assembly (1) for receiving signals of a body tissue (2) and/or transmitting signals to a body tissue (2) comprises at least one holding device (3) and at least one transceiver device (4). The transceiver device (4) comprises at least one first transceiver- magnetic element (5) and the holding device (3) comprises at least one first holding-magnetic element (6), the first transceiver-magnetic element (5) and the first holding-magnetic element (6) being arranged after one another with respect to a connection direction (C) and being configured to exert a magnetic force to one another. The transceiver device (4) comprises at least one second transceiver-magnetic element (7) and the holding device (3) comprises at least one second holding-magnetic element (8) being arranged after one another with respect to a transverse direction (T) and are configured to exert a magnetic force to one another. The transceiver device (4) is connectable to the holding device (3) via an overall magnetic force exerted by the first and second transceiver-magnetic elements (5; 7) and by the first and second holding-magnetic elements (6; 8).
A61B 5/273 - Connexion des cordons, des câbles ou des fils conducteurs aux électrodes
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
H01R 13/62 - Moyens pour faciliter l'engagement ou la séparation des pièces de couplage ou pour les maintenir engagées
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
in vitroin vitro in vitro system for forming of a glycosylated peptide or polypeptide using said conjugate. The invention further concerns an enzymatic synthesis system for the formation of a glycan-conjugate of this invention. The invention further concerns a peptide or polypeptide with a glycosyl-moiety acceptor residue having an exogenous N-linked glycosylation sequence X1X2NYT, wherein X1is any one of alanine (A), valine (V), leucine (L), isoleucine (I), proline (P), phenylalanine (F), cysteine (C), tryptophan (W) and methionine (M), and wherein X2is either alanine (A) or valine (V), as well as an N-glycosylated conjugate of said peptide or polypeptide.
C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
C07H 13/00 - Composés contenant des radicaux saccharide estérifiés soit par l'acide carbonique ou ses dérivés, soit par des acides organiques, p. ex. acides phosphoniques
There is provided inter alia a process for the isolation of circulating tumour cell (CTC) clusters and/or circulating tumour cell-white blood cell (CTC-WBC) clusters comprising: (i) collecting an apheresis sample from a patient; (ii) debulking the apheresis sample of excess white blood cells; (iii) separating CTC clusters and/or CTC-WBC clusters from other components of the debulked apheresis sample using microfluidic separation; and (iv) isolating separated CTC clusters and/or CTC-WBC clusters; wherein the debulking step comprises a flow-based process where flow is driven by gravity and/or minimal applied artificial pressure; wherein the microfluidic separation is performed using a microfluidics device capable of separating CTC clusters and/or CTC-WBC clusters from other components of the debulked apheresis sample.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
