A composition comprising at least two materials of materials A, B, and C; wherein A is selected from the group consisting of nucleic acid, single-stranded deoxyribonucleic acid (ssDNA), double-stranded deoxyribonucleic acid (dsDNA)and ribonucleic acid (RNA);5 B is selected from the group consisting of metalloprotein, ferritin, serum albumin such as bovine serum albumin (BSA), histone, lysozyme, fibrinogen, fibronectin, silk protein, transferrin, peptides comprising basic amino acids, chlorophyll-protein complexes, peridinin-chlorophyll- protein complex (PCP), chlorophyll a/b binding proteins, Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase), ATP Synthase, NADP+ Reductase, cytochrome, ferredoxin, plastocyanin 10 (PC), photosystem proteins, ribosomal proteins, mitochondrial proteins, NADH Dehydrogenase, humanin, and MOTS-c; and C is selected from the group consisting of collagen, aminated collagen, gelatin, aminated gelatin, poly-l-lysine, poly-histidine, poly-arginine, chitosan, aminated pectin, aminated polythylene glycol, polyethylenimine (PEI), polyacrylamide, and peptide nucleic acid (PNA);15 wherein the composition comprises a complex comprising at least two of the materials of the at least two materials.
The disclosure relates to a system for recording a physical parameter induced by a sample. The system comprises: a platform assembly for receiving the sample; a solid-state material having an outer layer embedded with colour centres sensitive to the physical parameter; a pump light source configured to irradiate the colour centres with pumping light; an optical system for directing fluorescent light from the colour centres; a plurality of photodetectors, wherein the optical system is configured such that respective photodetectors of the plurality of photodetectors detect fluorescent light from respective portions of the outer layer such that said respective photodetectors provide respective signals, and a processing unit configured to process the respective signals to establish a spatially resolved output indicative of the physical parameter. Each of the respective photodetectors is a PIN diode or a PN diode, wherein each of the respective photodetectors has a linear response to the fluorescent light.
G01N 24/00 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin
G01R 33/26 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique pour la mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques utilisant le pompage optique
The present disclosure provides for a composition comprising antigen-binding proteins capable of binding to, blocking, and/or neutralizing Type IA/IB cytotoxins, Orphan group XI toxins, Orphan group XIX toxins, aminergic toxins, Kunitz-type protease inhibitors, Type I α-neurotoxins (short-chain α-neurotoxins), Type II α-neurotoxins (long-chain α-neurotoxins), and phospholipase A2 (PLA2) toxins. The disclosure further provides for compositions comprising one or more of the disclosed antigen-binding proteins, which are capable of neutralizing snake venom lethality and dermonecrosis from medically relevant Sub-Saharan elapid snake species.
A sensor and a method for nonintrusive liquid pressure sensing in microfluidic systems is provided. The pressure sensor comprises a flat capillary tube section with enclosing walls formed of flexible material(s), so that a change in pressure within tube section will cause the enclosing walls to expand or contract. A pair of separate, flexible, thin electrode pads positioned opposite each other on opposing outer wide sides of the tube section. A pressure sensing unit is electrically connected to the electrode pads to form an impedance measuring circuit with a signal generator configured to generate a voltage signal in the first impedance measuring circuit and a processor configured to measure electrical impedance in the impedance measuring circuit. The measured impedance is indicative of a pressure within the tube section, and a pressure can be calculated or determined based on correlation data. A typical application of the sensor is in a liquid delivery device for administering doses of medicine to a patient.
G01L 9/00 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pressionTransmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent
6.
SUPPRESSION OF NEURONAL ACTIVITY USING A SINGLE-LAYER MICRO-COIL CHIP
The present disclosure relates to a system for suppression of neuronal activity The system comprises a single-layer micro-coil chip adapted for intracranial placement, the micro-coil chip having a tip with a bent micro-wire structure configured to generate localized enhanced electric field gradients adapted to induce suppression of neuronal activity in a target neuron or target neuronal region. The system further comprises a control unit configured to activate and modulate the magnetically induced electric fields generated by the micro-coil chip, wherein the control unit is configured to operate the micro-coil chip to generate an electric field with locally enhanced spatial gradients, thereby inhibiting neuronal activity in the target neuron or target neuronal region.
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/375 - Aménagements structurels, p. ex. boîtiers
A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
The invention relates to a pharmaceutical composition for use as a medicament, for example in the treatment of cancer and infectious diseases, in a subject in need thereof. The composition comprises isolated immune cells and modified aPD-L1 antibodies having an enhanced affinity for FcgammaRIIIa, and can further include dendritic cells. The invention further provides a method for expanding and activating NKT cells and iNKT cells or their CAR- derivatives.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
The disclosure relates to a method of generating light. The method comprises the steps of: providing a microresonator having a spatial optical comb mode and a spatial optical secondary mode; providing pump light to the microresonator; ramping the detuning of the pump light from a first to a second detuning such that the pump wavelength at the second detuning is between the comb mode and the secondary mode, wherein the step of ramping the detuning causes a coupling strength between the comb mode and the secondary mode to change and forms a tentative soliton state in the microresonator; ramping the detuning and/or a power of the pump light during and/or after forming the tentative soliton state to change said coupling strength and transform the tentative soliton state into a final soliton state being a single soliton state; and outputting at least a portion of light from the final soliton state.
The present invention concerns industrially applicable dehydrogenases (DHs) and aldo- keto reductases (AKRs) capable of converting deoxynivalenol (DON) into its non-toxic stereoisomer 3-epi-DON, suitable for incorporation into feed and food additives.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
C12P 41/00 - Procédés utilisant des enzymes ou des micro-organismes pour la séparation d'isomères optiques à partir d'un mélange racémique
The present disclosure relates to an image space telecentric imaging device for hyperspectral imaging of an object, the object defining an object plane and the imaging device defining an optical axis, the imaging device comprising: a first image space telecentric lens assembly configured to collect light emerging from the object plane to form an image in a first image plane defined by the telecentric lens assembly; a wavelength filter for spectral filtering of the light collected from the object plane, the wavelength filter defining a filter plane arranged such that the filter plane is parallel to and substantially coinciding with the first image plane; an actuator operatively coupled to the wavelength filter, configured to adjust the lateral position of the wavelength filter within the filter plane. The present disclosure further relates to a method for telecentric hyperspectral imaging based on passing light substantially collimated to the optical axis perpendicularly through the wavelength filter and controlling the lateral position of the wavelength filter within the filter plane via the actuator.
Disclosed herein is a method for in vivo vector assembly within a recombination-proficient bacterial cell, wherein a cassette comprising selection agents is provided to the cell and vectors comprising said cassette. Furthermore, cells comprising the vector are disclosed herein.
The present invention relates to bacterial cells and methods for valorisation of cyanide. In particular, the invention relates to engineered, or non-natural Pseudomonas cells capable of assimilating cyanide as carbon and nitrogen source, as well as methods for producing value-added compounds from cyanide using such cells.
C12N 9/00 - Enzymes, p. ex. ligases (6.)ProenzymesCompositions les contenantProcédés pour préparer, activer, inhiber, séparer ou purifier des enzymes
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
The present invention relates to lysates of Yarrowia cells, which recombinantly produce bovine growth-associated factors. Also provided is a fetal bovine serum (FBS) replacement composition comprising said lysates and methods for producing such.
There is presented a computer-implemented method (100) for assessing drug efficacy, comprising receiving (102) an optical coherence tomography (OCT) data set, analysing (104) the OCT data set to obtain a plurality of metric values, wherein the plurality of metric values is comprising a metric value for one or more or all of the metrics within a group of metrics comprising a cut-off spatial frequency metric, wherein the value of the cut-off spatial frequency metric relates to a frequency separating high- and low frequency content, and a ratio metric, wherein the value of the ratio metric relates to a ratio between high- and low spatial frequency content, and assessing (106) a drug efficacy based on the plurality of metric values.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01B 1/00 - Instruments de mesure caractérisés par l'usage d'un matériau spécifique
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G01B 9/02091 - Interféromètres tomographiques, p. ex. à cohérence optique
A61B 3/10 - Appareils pour l'examen optique des yeuxAppareils pour l'examen clinique des yeux du type à mesure objective, c.-à-d. instruments pour l'examen des yeux indépendamment des perceptions ou des réactions du patient
The present disclosure relates to an autonomous decision-making method for dynamical power sharing for a cluster of one or more controllable power units, comprising: obtaining for each controllable power unit a local power setpoint using a global reference power of the cluster, and a global power consumption or production of the cluster; continuously calculating and updating the local power setpoint for each controllable power unit using a feedback loop using the global reference power of the cluster, the global power consumption or production of the cluster, a local priority factor for each controllable power unit, and a local compensation factor for each controllable power unit. The present disclosure further relates to a system configured for dynamical power sharing for a cluster of one or more controllable power units. The present disclosure enhances scalability, mitigates single points of failure, and reduces data communication needs, making it suitable for applications that require secure, efficient, and decentralized power management, such as electric vehicle charging.
H02J 3/46 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs contrôlant la répartition de puissance entre les générateurs, convertisseurs ou transformateurs
The present invention provides a multiphase silicone composition comprising a. a first phase comprising silicone, wherein said silicone comprises a vinyl- functionalized silicone polymer, and optionally a catalyst, b. a second phase comprising silicone, wherein said silicone comprises a cross linker, c. optionally a third phase, wherein at least one of said phases in the composition comprises an acid, and wherein at least one of said phases in the composition comprises a base, wherein said base is a carbonate or a bicarbonate, and wherein said acid and said base is present in difference phases in the composition, and wherein at least one of said phases in the composition comprises glycerol, and wherein at least one of said phases in the composition is an emulsion.
A61L 15/26 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carboneLeurs dérivés
C08J 9/08 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent chimique de gonflage dégageant de l'anhydride carbonique
17.
ENZYMES WITH URETHANASE, AMIDASE AND/OR ESTERASE ACTIVITY AND USE THEREOF
The invention relates to polypeptides having urethanase activity and to their use in methods for cleaving urethane bonds and in methods for cleaving ester and amide bonds. The invention also relates to compositions comprising the polypeptides and a substrate comprising at least one urethane bond, ester bond or amide bond. Finally, the invention relates to nucleic acid fragments encoding the polypeptides and to vectors and cells comprising the nucleic acid fragments.
C12N 9/80 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides aliphatiques
The current disclosure relates to a method for determining the presence of a specific variant of a given protein, for example hemoglobin, capable of binding an analyte, for example oxygen, in cells of a biological sample, said method comprising determining the binding affinity of said analyte to said protein in a plurality of cells, for example red blood cells within said sample. The protein can be hemoglobin, which is capable of binding to oxygen, and the presence of specific variant of hemoglobin in cells of a blood sample is determined by the oxygen binding affinity of hemoglobin in a plurality of red blood cells within said sample. The method is also used for determining the presence of one or more specific types of red blood cells in a blood sample comprising analysing a blood sample using hyperspectral imaging. The method further relates to monitoring a disease associated with the presence of a specific variant of a given protein capable of binding an analyte in cells of an individual afflicted with said disease, wherein the method comprises the step of determining the presence of said specific variant of said protein in cells of a biological sample obtained from said individual. For example, the method is used for monitoring a disease associated with the presence of a specific variant of hemoglobin in red blood cells in an individual and/or in a fetus carried by said individual, wherein the method comprises determining the oxygen binding affinity of hemoglobin in a plurality of red blood cells in a blood sample from obtained from said individual. Moreover, the method is used for monitoring a disease relating to the presence of different types of red blood cells in an individual and/or in a fetus carried by said individual, wherein the method comprises the step of determining the presence of one or more specific types of red blood cells in a blood sample obtained from said individual by analysing said blood sample using hyperspectral imaging. The disclosure also relates to a measuring instrument configured to perform measurements following the disclosed methods.
G01N 33/72 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir les pigments du sang, p. ex. l'hémoglobine, la bilirubine
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
The present disclosure relates to a method for volumetric 3D printing of a three-dimensional object, the method comprising: obtaining a model of the object and a model of a container; computing an projection data based on the models of the object and the container; and providing projection data derived from the projection data to an illumination system configured to generate a series of projections for controlled polymerization of a photosensitive medium. The present disclosure further relates to systems for volumetric 3D printing of a three-dimensional object.
B29C 64/129 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective caractérisés par la source d'énergie à cet effet, p. ex. par irradiation globale combinée avec un masque
B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
The present invention relates to a method for manufacturing a MAX phase ceramic, use of a MAX phase ceramic as a pigment, and a pigment comprising a MAX phase ceramic. In particular the MAX phase ceramics of the invention are characterized by a predefined and controllable particle morphology allowing for tailored compositions of flake particles particularly suitable as pigments and in various coatings.
C09C 1/00 - Traitement de substances inorganiques particulières, autres que des charges fibreuses Préparation du noir de carbone
C04B 35/56 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbures
The present invention relates to enzyme selection systems for glycine amidinotransferase and guanidinoacetate methyltransferase, and the use of these optimized enzyme in fermentation processes. In particular, the present invention relates to the production of creatine, using such enzymes, as well as cells optimized for creatine production.
A monolithic bipolar multi-transport stack component for an electrochemical stack and method for manufacturing such are disclosed. The component comprises a fluidically impermeable and electrically conductive central layer having an anode-side and a cathode-side; recess structures provided on the anode side and on the cathode-side of the central layer, and electrically conductive and fluidically permeable outer layers provided on the recess structures on the anode-side and the cathode-side of the central layer so that the recess structures form flow fields between and parallel to the central layer and the outer layers. The central layer, the recess structures, and the outer layers have been formed via powder processing, adhered together before sintering; and sintered in a single sintering process whereby all layers are monolithically connected. The component is thereby a single monolithic component providing the functionality of a bipolar plate, a flow field, and a porous transport layer for each of two adjacent electrochemical cells. No passivation layers can form between the parts of the component providing the functionalities and therefore no Pt coatings between these parts needed.
B22F 5/10 - Fabrication de pièces ou d'objets à partir de poudres métalliques caractérisée par la forme particulière du produit à réaliser d'articles avec des cavités ou des trous, non prévue dans les sous-groupes précédents
C25B 11/071 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau du substrat ou du support formé d’un élément et d’au moins un composéÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau du substrat ou du support formé de plusieurs composés comprenant des poudres métalliques ou d'alliages, et des liants non métalliques
B22F 1/10 - Poudres métalliques contenant des agents lubrifiants ou liantsPoudres métalliques contenant des matières organiques
C25B 9/65 - Dispositifs pour l'alimentation en courantConnexions d'électrodesConnexions électriques intercellulaires
C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
C25B 15/08 - Alimentation ou vidange des réactifs ou des électrolytesRégénération des électrolytes
B22F 7/06 - Fabrication de couches composites, de pièces ou d'objets à base de poudres métalliques, par frittage avec ou sans compactage de pièces ou objets composés de parties différentes, p. ex. pour former des outils à embouts rapportés
B22F 3/11 - Fabrication de pièces ou d'objets poreux
23.
SPORULATION-DEFICIENT BACTERIAL CELLS AND METHODS FOR THEIR USE
The present invention relates to sporulation-deficient bacterial cells and methods of their use for production of volatile compounds, in particular acetone, butanone, and/or isopropanol. Also provided are nucleic acid constructs, vectors and host cells useful in such methods.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
The present disclosure relates to a method of providing light. The method comprises: providing a chamber filled with a gas; injecting a pump pulse train into the chamber with pulses being spaced by a pump pulse interval; generating a frequency-converted pulse train by frequency conversion via stimulated Raman scattering with the gas, wherein the pulses of the pump pulse train induce coherent oscillations of the gas which facilitates said stimulated Raman scattering, the coherent oscillations having a dephasing time; and outputting the frequency-converted pulse train. A ratio of the pump pulse interval to the dephasing time is at most 10.0. Some pulses of the pump pulse train each serves both to: generate a pulse of the frequency-converted pulse train via coherent oscillations induced by previous pulse(s) of the pump pulse train; and enhance the coherent oscillations for the conversion of a subsequent pulse of the pump pulse train. [Fig. 2b]
H01S 3/30 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet utilisant des effets de diffusion, p. ex. l'effet Brillouin ou Raman stimulé
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
H01S 3/094 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente
25.
MECHANISM FOR PROVIDING A LINK WITH VARIABLE STIFFNESS
The invention relates to a mechanism (1) with variable stiffness. It comprises a plurality of solid, discrete elements (2) arranged at least in series and at least one connector (3) interconnecting elements. The at least one connector is configured to apply a tensional force (F) of variable size between the series of elements, so that by varying the size of the tensional force, at least the transversal stiffness of the mechanism is varied accordingly. The mechanism constitutes a pivoting system with equilibrium defined by the shape of the elements. The mechanism is configured to adapt to externally applied interaction forces during use by adjusting the tensional form force applied by the connector in response to the applied interaction forces.
A spatial offset optical coherence tomography (SO-OCT) system comprising an illumination source for illuminating a sample by an illumination beam along an illumination path, a detection unit configured to capture a first image by a collection beam from the sample along a collection path, wherein the collection path is spatially offset from the illumination path by a spatial offset, and optionally angularly offset, from the illumination path by an angular offset, wherein the system is configured to shape the illumination beam as a shaped illumination beam, and wherein the detection unit is configured to receive the collection beam as a shaped collection beam, and wherein the system is configured to shape the illumination beam and the collection beam independently of each other.
The present invention relates to analogues of the sweet protein brazzein. In particular, the invention relates to analogues of brazzeins, said analogues having increased thermostability, host cells and methods for producing same.
A23L 27/00 - ÉpicesAgents aromatiques ou condimentsÉdulcorants artificielsSels de tableSubstituts diététiques du selLeur préparation ou leur traitement
The present disclosure relates to a hydrogel composition comprising: a hydrogel composition comprising: a first polymer comprising aldehyde groups; a second polymer comprising amine groups or amide groups; a crosslinking agent comprising amine groups; and at least one type of conductive nanoparticles.
A61L 15/18 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux inorganiques
A61L 15/42 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 15/60 - Matériaux gonflant avec les liquides pour former un gel, p. ex. super-absorbants
A61L 15/64 - Utilisation de matériaux caractérisés par leur fonction ou leurs propriétés physiques spécialement adaptés pour être résorbables à l'intérieur du corps
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 15/22 - Bandages, pansements ou garnitures absorbant les fluides physiologiques tels que l'urine, le sang, p. ex. serviettes hygiéniques, tampons contenant des matériaux macromoléculaires
29.
DEVICE AND METHOD FOR THE GENERATION OF PHOTONIC NANOJETS
A device for generating photonic nanojets is provided, the device comprising: a micro-optical arrangement comprising multiple micro-optical elements, and a spatial light modulator optically coupled to an input side of the micro-optical arrangement; wherein the spatial light modulator is adapted to receive incoming light, to spatially modulate at least a phase of the incoming light to produce a spatial distribution of phase modulated input light, and to illuminate the input side of the micro-optical arrangement with the spatial distribution of phase modulated input light, thereby simultaneously generating an ensemble of individually steered photonic nanojets on an output side of the micro-optical arrangement. A system for generating photonic nanojets on a substrate comprises such a device and a coherent light source for generating incoming light. A method of producing such a device includes steps of concurrently optimising the micro-optical array and the modulated illumination, e.g. using a Bayesian framework for inverse scattering.
G02F 1/29 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de la position ou de la direction des rayons lumineux, c.-à-d. déflexion
G02B 27/09 - Mise en forme du faisceau, p. ex. changement de la section transversale, non prévue ailleurs
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
G02B 26/06 - Dispositifs ou dispositions optiques pour la commande de la lumière utilisant des éléments optiques mobiles ou déformables pour commander la phase de la lumière
30.
IONIC LIQUID MEDIATED VALORISATION OF CARBON DIOXIDE
22 valorisation into value-added products such as formic acid. In particular, such valorisation is achieved in a reaction media comprising a catalyst and an ionic liquid.
Disclosed is a monolithic solid oxide cell unit (2) comprising an inner wall part (3) shaped as a Triply Periodic Minimal Surface, TPMS, in order to divide the space within the monolithic solid oxide cell unit into at least two disjoint sub-volumes providing an anodic sub-volume and a cathodic sub-volume, the inner wall part (3) being formed in a material composition that provides an electrolytic separation between the anodic sub-volume and the cathodic sub-volume. The monolithic solid oxide cell unit comprises an outer wall part (4) connected to and at least partly enclosing the inner wall part (3) with the anodic sub-volume side of the inner wall part and the outer wall-part forming an anodic gas channel having an inlet (16) and an outlet, and the cathodic sub-volume side of the inner wall part and the outer wall-part forming a cathodic gas channel having an inlet and an outlet (18).
H01M 8/124 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte
B33Y 80/00 - Produits obtenus par fabrication additive
H01M 8/2404 - Procédés ou appareillages pour le groupement d’éléments à combustible
H01M 8/2435 - Éléments à haute température avec électrolytes solides avec une structure centrale monolithique, p. ex. les nids d’abeille
The disclosure regards a quantum communication system for a QKD protocol comprising an optical transmitter comprising a state generation source, configured to generate squeezed states, a coherent modulation source, configured to generate modulated coherent states, a displacement beamsplitter, configured to 1) interfere a 5 squeezed state from the state generation source with a modulated coherent state from the coherent modulation source, and 2) generate displaced squeezed states. The system further comprises an optical receiver comprising a local oscillator for interference with the displaced squeezed states, a state detection unit for detecting quadrature components of the displaced squeezed states after interference with the 10 local oscillator, and a digital signal processing module comprising a carrier frequency recovery unit, a carrier phase recovery unit, a quadrature remapping unit and a squeezing angle compensation module, the digital signal processing module configured to reconstruct the displaced squeezed states by estimating a fluctuating phase and a fluctuating frequency from the quadrature components, wherein said 15 fluctuating phase and fluctuating frequency are induced by the local oscillator
The present invention relates to the field of generative protein binder design, specifically pMHC binder design, using methods and computer implemented methods which relies on specifically trained neural networks using e.g., diffusion modelling and message passing neural networks (MPNN).
The invention relates to a method for manufacturing a nickel coated porous structure, the method comprising the following steps: a) obtaining one or more polymer fibers comprising nickel salt; b) reducing at least a part of the nickel salt to form metallic nickel; and c) electroless plating of the one or more polymer fibers obtained in step b), using a plating solution, the one or more polymer fibers to form one or more nickel coated polymer fibers, wherein step c) is performed after step b); and wherein the porous structure is a microporous and/or nanoporous structure.
C23C 18/36 - Revêtement avec l'un des métaux fer, cobalt ou nickelRevêtement avec des mélanges de phosphore ou de bore et de l'un de ces métaux en utilisant des agents réducteurs d'hypophosphites
35.
CONTINUOUS AND/OR SEMICONTINUOUS GRINDOMETER AND METHOD FOR FINENESS OF GRIND MEASUREMENT
The present disclosure relates to continuously or semi-continuously measurement of the fineness of grind or the maximum size of particles suspended or dispersed in a liquid, in particular in formulated liquid product, such as a paint. One embodiment relates to an apparatus for continuously or semi-continuously measuring the fineness of grind or the maximum size of particles suspended or dispersed in a liquid, such as a formulated liquid product, e.g. a paint, which apparatus comprises a substrate and an applicator, wherein the substrate is arranged so that liquid can be applied onto a first surface of the substrate, for instance by immersing a part of the substrate in the liquid or by dousing the substrate with the liquid, wherein the substrate and the applicator are configured to continuously or semi-continuously move relative to each other, wherein the applicator is arranged so that, liquid, which has been applied onto the first surface, can pass through a gap defined between the applicator and the first surface, the gap and the relative movement of the substrate and the applicator thereby forming a liquid film on the first surface, wherein the size of the gap varies along the applicator, such that particles suspended or dispersed in the liquid are held back by the applicator depending on their size, thereby continuously or semi-continuously forming a scratch pattern in the liquid film.
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
36.
CORRECTION OF SYSTEMATIC DELAY ERRORS OF AN OPTICAL DELAY DEVICE
A method, a system, and an electronic device for determining systematic delay errors for an optical delay device are disclosed. A time-domain signal of a sample is recorded using a THz time-domain setup utilizing the delay device for adjustment of a delay between a THz signal and a light signal overlapping in a THz receiver, the sample having at least one absorption line in the THz range. An optimization algorithm configured to find a candidate delay error curve by iteratively: generating a candidate delay error curve, reconstructing a time-domain signal by applying the candidate delay error curve to the recorded time-domain signal; calculating a frequency spectrum based on the reconstructed time-domain signal; and determining one or more absorption line features in the calculated frequency spectrum. An objective of the optimization algorithm is to find the candidate delay error curve that results in absorption lines in the frequency spectrum that most resemble true absorption lines. The optimization algorithm finds a delay error curve corresponding to an extremum in an objective function comprising the one or more absorption line features. The determined delay error curve can be used to correct or calibrate for linear and nonlinear systematic delay error of the delay device. Fig. 1 is to be published with the abstract.
The invention provides engineered bacterium capable of expressing an AhR agonist or a composition comprising said bacterium, for use in cancer treatment - e.g. immunotherapy; and methods for using the engineered bacterium for therapeutic purposes.
C12N 9/04 - Oxydoréductases (1.), p. ex. luciférase agissant sur des groupes CHOH comme donneurs, p. ex. oxydase de glucose, déshydrogénase lactique (1.1)
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/06 - Oxydoréductases (1.), p. ex. luciférase agissant sur des composés contenant de l'azote comme donneurs (1.4, 1.5, 1.7)
The disclosure regards a signal mode-matching system for coherent optical receivers, the system comprising, an optical hybrid for receiving an optical signal, and comprising a local oscillator, the optical hybrid configured to separate the optical signal to a plurality of orthogonal components, and configured to interfere the plurality of orthogonal components of the optical signal with the local oscillator, a pair of photodiodes per orthogonal component, configured for detecting the outcomes of the interference for each corresponding orthogonal component, each photodiode of the pair generating a primary photocurrent, each pair of photodiodes combined such that the two primary photocurrents of each pair of photodiodes generate a combined photocurrent, a plurality of variable optical attenuators, one for each photodiode, each variable attenuator positioned between the optical hybrid and its corresponding photodiode, and an analog to digital converter configured to digitize each of the plurality of combined photocurrents corresponding to the orthogonal components, wherein the signal mode-matching system is configured to equalize the detection of each orthogonal component by performing frequency dependent gain-balancing in the digital domain using the output of the analog to digital converter, and controlling the variable optical attenuators to maximize the equalization of the optical efficiencies of the plurality of orthogonal components, thereby maximizing mode-matching among the different orthogonal components.
The disclosure regards an optical entanglement system for generating an at least three-dimensional cluster state for measurement-based optical quantum computation, the optical entanglement system having as input a plurality of pairs of quantum states, the system comprising a beam-splitter network, comprising at least twelve beam splitters, and at least eight input modes, wherein each input mode is configured to host a quantum state, a plurality of delay lines, each delay line configured for generating a time delay on one of the quantum states in at least one pair of quantum states, wherein the system is configured for entangling the pairs of quantum states utilizing the beam-splitter network and the induced time delays, thereby generating an at least three-dimensional cluster state.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
C12P 17/16 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles
The invention relates to a thermophilic bacterium comprising a carbonic anhydrase, wherein the carbonic anhydrase is attached to and/or expressed on the surface of the thermophilic bacterium. The invention also relates to specific variants of a carbonic anhydrase, and it relates to a method of capturing carbon dioxide using the thermophilic bacterium or the carbonic anhydrase variants of the invention.
The application regards a system for manufacturing a three- dimensional object, the system comprising an irradiation system comprising one or more energy sources; a control system arranged to freely control the orientation and the three-dimensional position of the one or more energy sources, by at least one actuator.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p. ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
The present invention relates in one aspect to an absorption spectroscopy apparatus for measuring one or more gases in an atmosphere, wherein the apparatus comprises a wavelength-tunable laser source, a control circuit configured to provide an electrical drive current to the wavelength-tunable laser source; wherein the control circuit is configured to create the electrical drive current as a modulated drive current, wherein the modulated drive current alternates between at least a first and a second drive current, the first drive current configured to cause the wavelength-tunable laser source to emit laser radiation at a first wavelength and the second drive current configured to cause the wavelength-tunable laser source to emit laser radiation at a second wavelength, different from the first wavelength, and wherein the modulated drive current defines a sequence of pulses, each pulse having a non-rectangular pulse shape.
G01N 21/39 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant des lasers à longueur d'onde réglable
G01J 3/42 - Spectrométrie d'absorptionSpectrométrie à double faisceauSpectrométrie par scintillementSpectrométrie par réflexion
G01J 3/433 - Spectrométrie par modulationSpectrométrie par dérivation
G01J 3/10 - Aménagements de sources lumineuses spécialement adaptées à la spectrométrie ou à la colorimétrie
G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
45.
DEXTRAN NANOPARTICLES FOR T-CELL ACTIVATION AND PROLIFERATION
The invention relates to antigen-functionalized dextran-based nanoparticles capable of activating, functionally modifying, re-programming, and stimulating expansion of T cells, A pharmaceutical comprising the nanoparticles find use in the treatment of a medical condition requiring the activation and/or expansion of T-cells and/or in the production of receptor engineered-T cells used in such treatments.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
The invention relates to an in-tube check valve (1) which is inserted in a tube (13) for or is insertable in a tube for fluid flow. The check valve comprises a stator (12), an adjustment part (11), a closure element (16), and a spring (17). The stator comprises an inlet (14) and a valve seat (15) and the adjustment part comprises an outlet (18) and an external thread (21). The external thread is arranged to engage with the inner wall (22) of the tube, and the adjustment part (11) and the stator are placeable with an operational distance (25) between them, and said operational distance is adjustable by reversible screwing the adjustment part into the tube facilitated by the external thread's engagement with the inner wall of the tube.
F16K 15/04 - Soupapes, clapets ou valves de retenue à corps de soupapes rigides guidés en forme de sphère
F16K 17/04 - Soupapes ou clapets de sûretéSoupapes ou clapets d'équilibrage ouvrant sur excès de pression d'un côtéSoupapes ou clapets de sûretéSoupapes ou clapets d'équilibrage fermant sur insuffisance de pression d'un côté actionnés par ressort
F16K 27/02 - Structures des logementsMatériaux utilisés à cet effet des soupapes de levage
47.
NICKEL/SUPPORT - TERNARY EUTECTIC SALT CATALYST, USE THEREOF AND METHODS OF MANUFACTURE
The present invention relates to novel catalyst materials including use thereof in catalytic transformations, such as in methods of producing syngas from mixtures of methane and carbon dioxide. The present invention further relates also to use of such novel catalysts in methods of improving operando life-time of a heterogenous catalyst comprising at least one active surface prone to carbon deposition and deactivation.
The present invention relates to the field of PCR amplification and uses thereof, and specifically relates to leaping PCR reactions, where only a fraction of a target nucleic acid is amplified in the PCR reactions, wherein the PCR reaction produces an amplification product which comprises the terminal parts of a target nucleic acid but is devoid of a central part of the target nucleic acid.
The invention relates to a hemoglobin-based oxygen carrier where the carrier has a metal-organic framework to entrap hemoglobin and is provided as nanoparticles; as well as a method for preparing the nanoparticles. The invention further relates to a pharmaceutical comprising the hemoglobin-based oxygen carrier.
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/46 - Ingrédients de constitution indéterminée ou leurs produits de réaction, p. ex. peau, os, lait, fibre de coton, coquille d’œuf, fiel de bœuf ou extraits de plante
Various strategies can be used to address dendrite formation in zinc batteries, spanning from advanced electrode materials to optimized operating conditions. Addressing dendrite challenges is pivotal for bolstering safety in metal-based batteries. The invention relates to an electrolyte specifically designed to limit5 dendrite formation in Zn/Mg batteries providing a safer and more reliable metal or metal/air battery.
H01M 10/0569 - Matériaux liquides caracterisés par les solvants
H01M 10/0568 - Matériaux liquides caracterisés par les solutés
H01M 10/054 - Accumulateurs à insertion ou intercalation de métaux autres que le lithium, p. ex. au magnésium ou à l'aluminium
H01M 12/08 - Éléments hybridesLeur fabrication composés d'un demi-élément du type élément à combustible et d'un demi-élément du type à élément secondaire
51.
REMOVAL OF PFAS USING UV LIGHT AND SHORT-CHAIN CARBOXYLIC ACIDS
The present invention relates to a process for degradation of per- and polyfluoroalkyl substances (PFAS) in aqueous solutions using UV light and short-chain carboxylic acid additives. The process provides an advantage in being efficient, fast and environmentally sound, producing no complex hazardous bybroducts.
Methods are disclosed for heat treating a high-carbon steel component, including a high-carbon tool- steel component, printed by powder-based full-melt additive manufacturing, wherein the printed component contains at least 0.2 wt% C and comprises at least 30 vol% of an austenitic phase and wherein the composition of the component may be selected according to a modified Schaeffler diagram. The methods comprise applying a thermal treatment to decompose at least a fraction of the austenitic phase into at least a ferritic phase, austenitization, rapid cooling or quenching to a temperature below which austenite transforms to martensite, and tempering.
An electromechanically auxetic structural element defined by the application of coated electrodes on the larger two main surfaces encompassing the triply periodic minimal surface structures made of active materials that deform under the actuation of electrical fields. A structural element (10) comprising a base structure (11) defined by a triply periodic minimal surface having a thickness and two main surfaces that separated two disjoint sub-volumes (12, 14), wherein the base structure is made of an electromechanically functional material, wherein the surface (12') of the first sub-volume comprises a first coating of a first electrically conductive material (16), wherein the surface (14') of the second sub-volume comprises a second coating of a second electrically conductive material (16), and wherein the coating of the first sub-volume is arranged to not be in electrical contact with the coating of the second sub-volume. This structural element can fill any 3D-shaped volume, imparting an auxetic electromechanical response to the overall device (sensor, actuator or transducer).
Disclosed is a molecular sensor for detecting molecules dissolved in liquid, the molecular sensor comprising: a sensor housing, a measurement chamber comprised in the sensor housing and being fluidly coupled to an exterior of the sensor housing, and a quartz crystal microbalance (QCM). A quartz crystal resonator comprised in the QCM is functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and/or reversibly adsorb carbon dioxide, and the molecular sensor is configured such that liquid which enters the measurement chamber can come in direct contact with a surface of the MOF. Also disclosed is a method of detecting and/or quantifying molecules dissolved in a liquid, the method comprising the steps of: providing a molecular sensor comprising a quartz crystal microbalance (QCM), the QCM comprising a quartz crystal resonator, the QCM being functionalised with a metal-organic framework (MOF) which can reversibly adsorb methane and/or reversibly adsorb carbon dioxide; providing the liquid to a functionalised surface of the QCM such that the liquid directly contacts the functionalised surface.
The present disclosure relates to an optical system for determining at least one parameter of at least one particle. The system comprises a first light beam and a second light beam, a modulator, a sample carrier, one or more light detectors, and a data processing means. The modulator is arranged along a path of the first light beam and configured to modulate the first light beam. The sample carrier containing the at least one particle to be analyzed and arranged so that at least part of the sample with the at least one particle is provided at an interrogation region. The modulated first light beam and the second light beam are arranged to intersect with each other at the interrogation region and to form an interference pattern thereto. The sample with particles and the interference pattern are configured to move with respect to each other. The one or more light detectors are configured to detect an output signal scattered and/or emitted from the at least one particle being transported by the sample carrier and also being configured to deliver an electrical signal to the data processing means based on this output signal. The data processing means being configured to determine said at least one parameter of the at least one particle from the received electrical signal.
G01N 21/45 - RéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant des méthodes interférométriquesRéfringencePropriétés liées à la phase, p. ex. longueur du chemin optique en utilisant les méthodes de Schlieren
G01N 15/10 - Recherche de particules individuelles
56.
METHOD AND SYSTEM FOR OPTIMIZATION OF UNIT CELL TOPOLOGY OF A THERMAL ENERGY TRANSFER CHANNEL AS A PHYSICAL OBJECT
A computer-implemented method and computer-system for optimizing the design of a physical thermal energy transfer channel. The process involves defining a unit cell based on target design criteria, and then using these unit cells to form the channel. The optimization is performed at the unit cell level, focusing on improving thermal performance through iterative material redistribution within the cell. The optimized design parameters for the unit cell is output and used to manufacture the optimized thermal energy transfer channel with a specified arrangement of these unit cells as a physical object, based thereon.
G06F 30/28 - Optimisation, vérification ou simulation de l’objet conçu utilisant la dynamique des fluides, p. ex. les équations de Navier-Stokes ou la dynamique des fluides numérique [DFN]
The disclosure regards an unmanned aerial vehicle (UAV) comprising a main body, a frame, a plurality of propeller units attached to the frame, and a displacement mechanism configured to displace with three translational degrees of freedom the main body of the UAV with respect to the frame, thereby adjusting the center of mass of the 5 UAV in any spatial direction.
The disclosure regards a computer implemented method for estimating the reactivity of dissolved organic matter in a liquid comprising the steps of obtaining a first fluorescence measurement from the liquid, wherein the first fluorescence measurement comprises a first emission wavelength and a first excitation wavelength, obtaining a second fluorescence measurement from the liquid, wherein the second fluorescence measurement comprises a second emission wavelength and a second excitation wavelength, determining a sample photosensitivity index based on the first fluorescence measurement, the second fluorescence measurement and a conversion factor specific to said liquid, and estimating the reactivity of dissolved organic matter in the liquid based on the sample photosensitivity index, wherein the conversion factor is a correlation between a series of base photosensitivity indexes and a series of fluorescence measurement ratios, obtained from a liquid of a same type as the liquid. The present disclosure further relates to a computer implemented method for calibrating a fluorescence setup in relation to a liquid, and to an optical measurement system for estimating the reactivity of dissolved organic matter in a liquid.
G01N 21/27 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en utilisant la détection photo-électrique
The invention relates to a series of novel polymers that are stable in highly alkaline media while at the same time able to conduct ions under such conditions. The present invention further relates to use of such polymers in the preparation of membranes that find use in alkaline water electrolysers.
B01D 71/44 - Polymères obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, non prévus dans un seul des groupes
B01J 39/00 - Échange de cationsUtilisation d'une substance comme échangeur de cationsTraitement d'une substance en vue d'améliorer ses propriétés d'échange de cations
The present invention relates to the use of compositions comprising 4-hydroxyphenyllactic acid for the prevention and/or treatment of IgE-mediated diseases.
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61K 31/405 - Acides indole-alkanecarboxyliquesLeurs dérivés, p. ex. tryptophane, indométhacine
The invention relates self-polishing anti-fouling coating composition comprising a) a self-polishing binder, b) particles of a copper compound and/or a zinc compound; c) optionally a biocide, wherein the mean particle diameter of the copper compound and zinc compound is in the range of from 2 to 100 nm, preferably 5 to 50 nm such as in the range of from 8 to 40 nm, preferably in the range of from 10 - 30 nm, 12 - 25 nm, 14 - 20 nm, or 16 - 18 nm; and a coating made thereof.
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
The invention relates to a method for analyzing a first component of a fluid sample also comprising a second component where the sample is stepwise introduced further and further along a substrate and finally removed from at least the last wetted portion of the substrate. The analysis is performed at the last wetted portion of the substrate.
The present invention relates to a method for estimating or determining fitness of enzyme variants and/or optimizing a nucleotide sequence encoding an enzyme variant comprising generating a DNA variant library and linking a unique DNA barcode to each DNA variant, wherein the DNA variants are subjected to long-read and short-read sequencing. In particular, the present invention relates to a method for predicting or determining fitness of enzyme variants and/or optimizing a nucleotide sequence encoding an enzyme variant by combining DNA barcodes, selection pressure, long-read sequencing, and short-read sequencing. Furthermore, the present invention relates to application of machine learning for predicting enzyme fitness and/or optimizing a nucleotide sequence encoding an enzyme variant based on data obtained from said method.
The present disclosure relates to methods for production of phosphorylated recombinant animal proteins, phosphorylated phosphomimetic animal proteinsand phosphomimetic animal proteins, as well as the use of such animal proteins.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
66.
A METHOD OF, AND APPARATUS FOR, IMPROVED ESTIMATION OF FETAL CHARACTERISTICS
in uteroin utero; b) utilising the image data in a first machine learning model comprising one or more neural networks to generate one or more latent space representations of the anatomical structure and appearance of the fetus and one or more predicted measurements of the anatomical structure of the fetus; and c) utilising the one or more predicted measurements and the one or more latent space representations in a second machine learning model to generate an estimated weight of the fetus.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
G06T 7/62 - Analyse des attributs géométriques de la superficie, du périmètre, du diamètre ou du volume
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
67.
AN IMPROVED METHOD OF, AND APPARATUS FOR, ULTRASOUND EXAMINATION TO EXTRACT FETAL CHARACTERISTICS
There is provided a method of performing ultrasound examination of a fetus in utero, the method comprising the steps of: a) acquiring a plurality of ultrasound images of the fetus in utero using an ultrasound imaging apparatus, the ultrasound images comprising image data representative of the anatomical structure and appearance of a head, an abdomen and a femur of a fetus in utero; b) utilising, on a computing system, a plurality of sets of the ultrasound images in an ensemble machine learning model comprising one or more neural networks to determine an estimated fetal weight and generate an associated uncertainty estimate for the estimated fetal weight; c) providing, based on the uncertainty estimate, a notification to the operator of the ultrasound imaging apparatus in respect of one or more parameters indicative of the accuracy of one or more of the obtained ultrasound images.
The present disclosure relates to a multilayered gel pad comprising a first layer having a first surface that is non-adherent to patient tissue; and a second layer having a second surface that is adapted to be adherent to a target surface; wherein the first and second surface are on opposite outer sides of the gel pad and wherein the first layer is self-healing to the second layer.
The present invention relates to a polymer-based drug delivery system as such and its use in a method of treatment of a range of diseases and disorders, including cancer. The drug delivery system of the present invention is suitable for intracranial delivery and release of cytotoxic agents, in particular radioisotope-functionalized agents such as deoxyuridine.
A61K 47/59 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes
70.
NANOPARTICLE DRUG DELIVERY SYSTEM FOR RADIOTHERAPY IN THE BRAIN
The invention relates to the field of drug delivery of radioactive nucleosides for radiotherapy in the brain. The invention provides a composition comprising a prodrug of a radioactive Auger electron-emitting radionucleoside and a nanoparticle carrier, suitable for use in the treatment of brain tumors.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
72.
MICROPUMP WITH ELECTROSTRICTIVE MATERIAL ACTUATION
>n nnn n to generate a wave travelling of amplitude S along the capillary tube section. The micro-pump can be configured to operate as a travelling wave micro-pump (TWµP) by adjusting the driving signal so that 2S < 0,2h or to operate as a peristaltic micro-pump (PµP) by adjusting the driving signal so that 2S = 0,5h.
F04B 19/00 - "Machines" ou pompes ayant des caractéristiques particulières non prévues dans les groupes ou présentant un intérêt autre que celui visé par ces groupes
F04B 43/04 - Pompes ayant un entraînement électrique
F04B 43/08 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles ayant des organes flexibles tubulaires
METHOD FOR DESIGNING GEOMETRICALLY FITTING AND STRUCTURALLY OPTIMIZED PATIENT-SPECIFIC IMPLANT MODELS AND METHOD FOR TRAINING AN ARTIFICIAL INTELLIGENCE MODEL FOR DESIGNING GEOMETRICALLY FITTING AND STRUCTURALLY OPTIMIZED PATIENT-SPECIFIC IMPLANT MODELS
The present invention relates to a computer-implemented method (100) for designing a geometrically fitting and structurally optimized patient-specific implant model (1) in view of its manufacturing.
The present invention relates to an unmanned aerial vehicle comprising, a vehicle body; a plurality of rotors, each rotor having a rotational axis; and pivotal rotor couplings configured to facilitate pivotal adjustment of an orientation of the rotational axis of a respective rotor around a respective pivot axis. The vehicle has a UAV configuration in which the rotational axis of each rotor has an upright orientation, and a USV configuration in which the rotational axis of at least some rotors has a non-upright orientation. The vehicle is configured to be switched between the UAV configuration and the USV configuration via the pivotal rotor couplings. The plurality of rotors is located above a water surface when the vehicle floats on water in the USV configuration. At least some rotors have different horizontal orientations in the USV configuration. The invention further relates to a method of operating such a vehicle.
The present invention relates in one aspect to an absorption spectroscopy apparatus for measuring one or more gases in an atmosphere, wherein the apparatus comprises: a tunable laser source configured to emit laser radiation; an optical system for transmitting the emitted laser radiation as a probe laser beam, and for collecting return light, in particular emitted laser radiation reflected by a remote surface, the optical system defining one or more apertures; a photodetector for detecting the collected return light, wherein the apparatus defines a transmission beam path between the tunable laser source and a transmission aperture of said at least one apertures, and the apparatus defining a receiving beam path between a receiving aperture of said at least one aperture and the photodetector; wherein the optical system is configured to have a polarization-insensitive transmittance.
G01N 21/39 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant des lasers à longueur d'onde réglable
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01J 3/42 - Spectrométrie d'absorptionSpectrométrie à double faisceauSpectrométrie par scintillementSpectrométrie par réflexion
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
76.
INVARIANT NATURAL KILLER T CELL-ACTIVATING VACCINE AGAINST BACTERIAL INFECTIONS
Provided are vaccine compositions comprising a liposome, a bacterial polysaccharide antigen, and an invariant natural killer T (iNKT) cell agonist, methods of treating or preventing a bacterial infection using the compositions, and nasal spray devices comprising them.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
The present invention relates to glycoengineered extracellular vesicles, as well as methods of production of such glycoengineered extracellular vesicles, methods of glycoengineering extracellular vesicles, and uses of glycoengineered extracellular vesicles.
C12P 21/00 - Préparation de peptides ou de protéines
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
78.
NANOBODIES CAPABLE OF CROSS-BINDING TO SEVERAL DIFFERENT ELAPID THREE-FINGER TOXINS
The invention relates to a monoclonal binding agent comprising complementary determining regions CDR1, CDR2, and CDR3 of a single domain antibody (sdAb), the monoclonal binding agent being able to bind and/or block and/or neutralise Elapidae three-finger toxins (3FTx) of multiple snake species, wherein the monoclonal binding agent is selected from an antibody, an antibody format, an antibody fragment or an antibody analogue.
A kirigami device (1) comprising a foldable substrate (9), the substrate comprising: one or more discontinuous cuts (6) arranged such that the substrate may be moved from a planar configuration wherein the substrate extends substantially in a first plane, to an interlocking configuration wherein the substrate forms an expanded structure extending in three dimensions; and an interlocking mechanism comprising a first component and a second component, wherein the first component is disengaged from the second component in the planar configuration, and wherein the first component is engaged with the second component in the interlocking configuration, wherein the interlocking mechanism is arranged to retain the substrate in the interlocking configuration
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
80.
AN INTEGRATED ELECTRODE AND FLOW FIELD MATERIAL AND A METHOD TO MANUFACTURE SUCH A MATERIAL
C04B 35/524 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbone, p. ex. graphite obtenus à partir de précurseurs polymères, p. ex. carbone vitreux
H01M 4/86 - Électrodes inertes ayant une activité catalytique, p. ex. pour piles à combustible
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
H01M 8/08 - Éléments à combustible avec électrolytes aqueux
H01M 8/10 - Éléments à combustible avec électrolytes solides
81.
ENZYMATIC SYNTHESIS OF GLYCOSYLATED ANTHRANILATE DERIVATIVES
The present invention concerns enzymatic synthesis of glycosides of anthranilate derivatives, such as methyl anthranilate N-glucoside, ethyl anthranilate N-glucoside, and butyl anthranilate N-glucoside. These anthranilate derivatives may preferably be used as insect and/or bird repellent.
C12P 19/18 - Préparation de composés contenant des radicaux saccharide préparés par action d'une transférase glycosylique, p. ex. alpha-, bêta- ou gamma-cyclodextrines
A01N 33/06 - AminesComposés d'ammonium quaternaire l'atome d'azote étant lié directement à un système cyclique aromatique
A01N 33/10 - AminesComposés d'ammonium quaternaire contenant de l'oxygène ou du soufre au moins un atome d'oxygène ou de soufre au moins étant lié directement à un système cyclique aromatique
A01N 33/16 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux contenant des composés organiques de l'azote comportant des liaisons azote-oxygène
82.
SILICA REPLICAS DERIVED FROM MAMMALIAN CELLS TO DIRECT CELL LINEAGE DECISIONS OF MESENCHYMAL STEM CELLS
The invention relates to a method of differentiating immature cells to a specific cell lineage of interest and/or to a specific cell type, said method comprising: i) Silicificating cells of said specific cell lineage to obtain silicified cells; ii) Calcinating a plurality of the silicified cells to obtain a scaffold; iii) Contacting the scaffold with the immature cells; iv) Culturing the immature cells in contact with the scaffold in a culture medium, thereby inducing differentiation of the immature cells into differentiated cells of said specific cell lineage and/or of said specific cell type. The invention also relates to scaffolds, silicified cells and kits for the differentiation of cells.
A method for preparing an adhesive, said method comprising - providing catechol substituted chitosan in an aqueous solution with a pH in the range of pH 3-5, - admixing said aqueous solution with a salt to obtain a polymer-rich phase and a polymer-poor phase; and - isolating the polymer-rich phase to obtain said adhesive. Described is also an adhesive obtainable from said method and uses thereof.
The invention relates to a modified encapsulin nano-particle carrier for cell-targeted delivery of one or more therapeutic agent to a mammalian cell, wherein the agent may be a nucleic acid and/or protein capable of modulating the genome and/or modulating the expression of one or more native or non-native genes within said targeted cell. The nano-particles are composed of fusion polypeptides that are capable of binding and encapsulating a cargo of therapeutic agent, as well as cell-specific and intracellular delivery of the cargo to a target mammalian cell.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 38/00 - Préparations médicinales contenant des peptides
C12N 15/00 - Techniques de mutation ou génie génétiqueADN ou ARN concernant le génie génétique, vecteurs, p. ex. plasmides, ou leur isolement, leur préparation ou leur purificationUtilisation d'hôtes pour ceux-ci
C07K 14/195 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
85.
A BIOCATALYTIC ROUTE TO INDOLE, AND OPTIONALLY INDICAN AND/OR INDIGO
The present invention concerns in vitro enzyme biosynthesis of indole, and optionally further production conversion of the indole to indican and/or indigo; preferably provided as a one-pot solution.
C12P 17/10 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'azote comme unique hétéro-atome du cycle
C12P 17/16 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles
C12P 19/60 - Préparation d'O-glucosides, p. ex. glucosides avec un atome d'oxygène du radical saccharide lié directement à un hétérocycle autre que saccharide ou à un système cyclique condensé contenant un hétérocycle autre que saccharide, p. ex. coumermycine, novobiocine
The disclosure regards a method for additive manufacturing an object, comprising the steps of providing a first radiation source emitting a first radiation; providing a container containing the photocurable resin curable by the first radiation, the container comprising a wall transparent or at least semi-transparent to at least a part of the first radiation; providing a second radiation source, wherein the photocurable resin is non-curable by said second radiation source; determining at least one property of the wall by measuring a second radiation from or reflected by the wall; providing a surface submerged on the container containing the resin; and controlling a set of processing parameters based on the at least one property of the wall for forming at least one layer of an object by curing a part of the photocurable resin on the submerged surface.
B29C 64/124 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux utilisant des couches de liquide à solidification sélective
B29C 64/277 - Agencements pour irradiation utilisant des moyens de rayonnement multiples, p. ex. des micro-miroirs ou des diodes électroluminescentes multiples [LED]
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
C07D 209/56 - Systèmes cycliques contenant au moins trois cycles
C07D 497/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'oxygène et de soufre comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
Disclosed is a composition for intumescent coating. The composition comprises a silicon-based binder, an expandable agent, a thixotropic agent, and a silicate filler. The expandable agent is hydrated alkali silicate particles. Furthermore, an intumescent coating system is disclosed. The intumescent coating system comprises a primer, the composition for intumescent coating according to this disclosure, and optionally a top coat. Furthermore, a method for preparing a composition for intumescent coating is disclosed.
Provided are lactic acid bacteria which are deficient in thiamine and which are deficient in lactate dehydrogenase and/or lactate dehydrogenase activity, methods for producing such bacteria, and methods for producing pyruvate by culturing such bacteria in medium deficient in thiamine and under aeration.
C07D 471/22 - Composés hétérocycliques contenant des atomes d'azote comme uniques hétéro-atomes du système condensé, au moins un cycle étant un cycle à six chaînons avec un atome d'azote, non prévus dans les groupes dans lesquels le système condensé contient au moins quatre hétérocycles
G01N 27/30 - Électrodes, p. ex. électrodes pour testsDemi-cellules
C07D 209/56 - Systèmes cycliques contenant au moins trois cycles
91.
BIOLOGICAL PRODUCTION OF POLYHYDROXYALKANOATES AND MONOMERS THEREFOR USING ENGINEERED PSEUDOMONAS CELLS
The present invention relates to cells and methods for producing polymers from acetate. The invention also relates to cells with increased tolerance to short-chain organic acids, such as acetate. In particular, the invention relates to production of polyhydroxybutyrate (PHB), fluorinated 3-hydroxybutyrate and fluorinated PHB (F-PHB) from acetate and/or F-acetate using bacterial cells with increased tolerance to acetate.
The invention relates to a method for manufacturing a multilayer structure with internal voids, such as monolithic stacks for solid-state electrochemical devices such as batteries, SOFC/SOEC stacks, gas separation devices, etc. The method comprises providing green layers comprising a first binder and enclosing a mold material that fills out an interstice between the layers. The layers are adhered, such as by application of elevated pressure and/or temperature, to form a multilayered structure having a mold-filled interstice with no fluid connections to an outside of the multilayer structure. Thereafter, the multilayer structure is machined to provide a fluid connection between the at least one mold-filled interstice and the outside of the multilayer structure. A viscosity of at least part of the mold material is decreased to allow easy removal of the mold material from the at least one interstice via the fluid connection, thereby forming an internal void in the multilayer structure. The viscosity decrease is induced without initiating a phase change to gas phase in and/or combustion of the first binder, i.e., without initiating de-binding or binder burnout. After removal of the mold material, there are free access to the binder-containing materials inside the structure via the voids and fluid connections, and the multilayer structure can be heat treated to perform binder burnout and sintering without the risk of structural damage.
H01M 8/124 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte
B22F 5/10 - Fabrication de pièces ou d'objets à partir de poudres métalliques caractérisée par la forme particulière du produit à réaliser d'articles avec des cavités ou des trous, non prévue dans les sous-groupes précédents
B22F 7/02 - Fabrication de couches composites, de pièces ou d'objets à base de poudres métalliques, par frittage avec ou sans compactage de couches successives
B22F 7/06 - Fabrication de couches composites, de pièces ou d'objets à base de poudres métalliques, par frittage avec ou sans compactage de pièces ou objets composés de parties différentes, p. ex. pour former des outils à embouts rapportés
H01M 8/12 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé
93.
IN VIVO NEUTRALIZATION OF CORAL SNAKE VENOMS WITH AN OLIGOCLONAL NANOBODY MIXTURE
222 neurotoxin and short-chain alpha neurotoxin from coral snake venoms. The invention also relates to pharmaceutical compositions, kit of parts and kits for the treatment and diagnosis of snake envenomation.
C12Q 1/18 - Test de l'activité antimicrobienne d'un matériau
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
95.
A METHOD OF GENERATING SUPERCONTINUUM LIGHT AND A SUPERCONTINUUM LIGHT SOURCE
The invention relates to a method of generating supercontinuum light comprising : providing frequency comb pump light and auxiliary pump light, wherein an auxiliary centre frequency is spectrally detuned with respect to a comb centre frequency by an auxiliary pump detuning; pumping a nonlinear medium associated with dispersive wave generation at a dispersive wave frequency shifted by a dispersive wave detuning relative to the comb centre frequency; spectrally translating the frequency comb pump light via a cascaded four-wave mixing process induced by the auxiliary pump light to thereby generate cascaded comb light; generating a dispersive wave at the dispersive wave frequency, wherein the generation of the dispersive wave is induced by the cascaded comb light due to an integer multiple of the auxiliary pump detuning lying within a spectral range of the dispersive wave detuning; and outputting the cascaded comb light and the dispersive wave to thereby provide the supercontinuum light.
C07C 1/12 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir d'oxydes de carbone à partir d'anhydride carbonique avec de l'hydrogène
B01J 29/00 - Catalyseurs contenant des tamis moléculaires
C07C 29/154 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons par réduction exclusivement des oxydes de carbone avec de l'hydrogène ou des gaz contenant de l'hydrogène caractérisée par le catalyseur utilisé contenant du cuivre, de l'argent, de l'or ou leurs composés
C07C 45/49 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par réaction avec le monoxyde de carbone
A method for quantitative detection of glucose in a liquid sample using continuous wave (CW) Terahertz (THz) spectroscopy such as THz cross-correlation spectroscopy (CCS) or THz frequency domain spectroscopy (FDS) in an attenuated total reflection (ATR) setup is disclosed. A continuous-wave (CW) light signal is used to generate a THz signal reflecting off an internal face of a sample surface of an ATR element. An electric detection signal resulting from an interference between THz radiation from the sample and the CW light signal can be recorded while a phase or a frequency domain parameter of the CW light signal is adjusted. A spectrum of the electric detection signal as a function of an adjustment of a phase or a frequency domain parameter is recorded while an external face of the sample surface is in contact with a sample comprising a liquid solution of glucose. The recorded spectrum is analysed using a supervised machine learning algorithm trained on similarly recorded spectra from similar liquid solutions with known glucose levels to estimate a glucose level in the liquid solution of the sample. The method can be used for quantitative, non-invasive, in-vivo detection of glucose in living subjects and other active metabolic systems.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01N 21/3586 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz par spectroscopie térahertz dans le domaine temporel [THz-TDS]
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
A61B 5/0507 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio utilisant des micro-ondes ou des ondes térahertz
G01N 21/3563 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse de solidesPréparation des échantillons à cet effet
98.
METHODS AND CELLS FOR REMOVING LACTATE FROM ACID WHEY
The present invention relates to methods and bacterial cells for removing lactate from acid whey (AW) containing lactate. In particular, provided are de-acidified AW products and dried whey powders, for example spray-dried whey powders, obtained by the methods or bacterial cells disclosed herein.
A23J 1/20 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du lait, p. ex. caséinePréparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du petit-lait
99.
AN IMPROVED SERS SUBSTRATE WITH A LAYER COMPRISING HALIDE
A surface-enhanced Raman spectroscopy (SERS) substrate and methods for manufacturing SERS substrates is described. The SERS substrate comprises a gold surface portion on which a layer comprising a halide is provided. Described is a method for performing SERS for detection or sensing of an analyte, wherein the method comprises manufacturing a SERS substrate. Described is also a SERS substrate manufacturing kit suitable for manufacturing said SERS substrate and/or for performing SERS analyte detection and further the use of the provided SERS substrate(s) in a method for drug sensing.
An angled fiber-based neural implant for neuromodulation and a method to manufacture such a neural implant is presented. The angled fiber-based neural implant comprises a fiber shank for inserting in neural tissue. The fiber shank comprises an optical waveguide, and the optical waveguide comprises a core and a cladding adapted so that light is able to propagate along the length of the optical waveguide. The shape of the core is arranged for providing a substantially uniform intensity distribution of light radiation from the core at the fiber tip, and the fiber tip comprises an angled surface. The end of the core and the end of the plurality of conduits are exposed at the angled surface, so that the plurality of conduits emanates at two, or more, different levels, where each level comprises a different depth into the tissue.
brevets
