Abrégé

A housing (212) receives a syringe and includes a return spring (226) for
biasing the syringe from an extended position in which its needle (218)
extends from the housing to a retracted position in which it does not. A drive
spring (230) acts on a first drive element (232) and a second drive element
(234) acts upon the syringe to advance it from its retracted position to its
extended position and discharge its contents through the needle. The first
drive element is capable of movement relative to the second once a nominal
coupling position has been reached. A release mechanism is activated when the
first drive element (234) is further advanced to a nominal release position,
to release the syringe (214) from the action of the drive spring, whereupon
the return spring restores the syringe to its retracted position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (110) is described having a housing (112) that receives a
syringe (114) having a needle (118), wherein the syringe is supported in a
syringe carrier (150). The syringe and syringe carrier are biased by a return
spring (126) from an extended position in which the needle (118) extends from
the housing (112) through an exit aperture (128) to a retracted position in
which it does not. A drive spring (130) acts via a drive to advance the
syringe from its retracted position to its extended position and discharge its
contents through the needle and a return spring, brought into play when the
drive has reached a nominal return position, restores the syringe to its
retracted position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

A housing (12; 112, 212) receives a syringe and includes a return spring (26;
126, 226) for biasing the syringe from an extended position in which its
needle (18; 118, 218) extends from the housing to a retracted position in
which the it does not. A drive spring (30; 130, 230) acts on a first drive
elements (32; 132, 232) and a second drive element (34; 134, 234) acts upon
the syringe to advance it from its retracted position to its extended position
and discharge its contents through the needle. The first drive element is
capable of movement relative to the second when the former is acted upon by
the drive spring and the latter is restrained by the syringe (14, 114, 214). A
reservoir (48; 148, 248) is defined between the first drive element and the
second drive element, the volume of the reservoir tending to decrease as the
first drive element moves relative to the second when acted upon by the drive
spring. The reservoir contains a highly viscous fluid and has a vent (44; 144,
244) through which the fluid escapes as the volume of the reservoir.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device is described having a housing that receives a syringe. The
syringe is
biased by a return spring from an extended position in which the needle
extends from the
housing through an exit aperture to a retracted position in which it does not.
A drive
spring acts via a drive to advance the syringe from its retracted position to
its extended
position and discharge its contents through the needle and a return spring,
brought into
play when the drive has reached a nominal return position, restores the
syringe to its
retracted position. A releasable locking mechanism retains the syringe in its
retracted
position. A sleeve projects from the exit aperture and can be depressed to
release the
locking mechanism. A trigger has a rest position, in which it engages the
drive, retaining
it in a position corresponding to the retracted position of the syringe, and a
depressed
position, in which it no longer causes the drive to be so retained. The sleeve
normally
locks the trigger in its rest position. However, depression of the sleeve into
the exit
aperture, allows the trigger to be depressed. Thereafter, the trigger is
retained in its active
position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

The invention concerns an injection device (110) with a housing (112) adapted
to receive a syringe (114) having a discharge nozzle (118) and a plunger
(130). There is a trigger and a drive (134) arranged to act upon the plunger
on actuation of the trigger to advance the syringe from a retracted position
to an extended position through an opening (150) in the housing. A locking
mechanism (160, 170) is arranged in and moveable relative to the housing. The
locking mechanism is engaged with the plunger when the syringe is not in its
extended position and disengaged from the plunger when the syringe is in its
extended position. This means that movement of the plunger relative to the
syringe is prevented when, in use, the syringe is advanced from a retracted
position to an extended position. Hence the contents of the syringe are not
expelled from the syringe during advancement form the retracted position to
the extended position. Hence the contents of the syringe are not expelled from
the syringe during advancement form the retracted position to the extended
position. The contents are only expelled when the syringe reaches the extended
position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device is described. A housing receives a syringe and includes a
return
spring for biasing the syringe from an extended position in which its needle
extends from
the housing to a retracted position in which the it does not. A drive spring
acts on a first
drive element and a second drive element acts upon the syringe to advance it
from its
retracted position to its extended position and discharge its contents through
the needle.
The first drive element is capable of movement relative to the second once a
nominal
decoupling position has been reached. A release mechanism is activated when
the first
drive element is further advanced to a nominal release position, to release
the syringe
from the action of the drive spring, whereupon the return spring restores the
syringe to
its retracted position. The nominal decoupling and release positions are
defined relative
to the syringe. This may be achieved by interaction between a moving component
and a
decoupling component that moves with the syringe as it is advanced.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

A syringe (114) is received with a housing, the syringe having a bore
terminating at a forward end in a hypodermic needle (118) and at a rearward
end in a flared opening (210) in which a bung (134a) having a bore (206)
surrounded by a skirt (208) is inserted. A drive element (134) has a forward
end consisting of a substantially flat annular region (200) that bears upon
the skirt of the bung and surrounds a conical middle region (202) that is
received in the bore (206) of the bung. An actuator advances the drive element
(134) so as to advance the bung and discharge the contents of the syringe
through the needle (118). The opening (210) in the rear of the glass syringe
is flared by being provided with a radius. The combination of the radius at
the opening and the projecting conical middle region of the drive element
allows misalignments of the two to be managed during automated assembly.

Classes IPC  ?

• A61M 5/24 - Seringues à ampoules, c.-à-d. seringues à aiguille utilisables avec des ampoules ou des cartouches échangeables, p. ex. automatiques

Abrégé

An injection device (110) is described having a housing (112) that receives a syringe (114) having a needle (118), wherein the syringe is supported in a syringe carrier (150). The injection device (110) has a removable cap (190). The syringe (114) and syringe carrier (150) are biased by a return spring (126) from an extended position in which the needle (118) extends from the housing (112) through an exit aperture (128) to a retracted position in which it does not. The syringe carrier (150) abuts a surface inside the removable cap (190) which prevents forward movement of the syringe carrier (150) when the cap is in place. The injection device is less prone to failure than prior art devices and is safer should failure occur.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device is of the type which has a housing defining a first axis and which is adapted to receive a syringe having a discharge nozzle, so that the syringe is movable between a retracted position, in which the discharge nozzle is contained within the housing, and an extended position, in which the discharge nozzle extends from the housing through an exit aperture. A trigger is movable from a rest position, in which it causes the drive to be retained, to an active position, in which it no longer causes the drive to be retained. A releasable locking mechanism is movable from a first position, in which the trigger is prevented from moving into its active position, to a second position, in which the trigger can be moved to its active position. The trigger and the releasable locking mechanism are arranged such that the trigger moves to its active position when the releasable locking mechanism is moved to its second position whilst pressure is being applied to an activation surface of the trigger.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device comprises a locking mechanism (171c) between a syringe
carrier (127) and a release mechanism
(102) to inhibit movement of the syringe carrier and syringe held by the
syringe carrier towards an exit aperture of the injection
device when the release mechanism is in its engaged position. The engaged
position of the release mechanism is a position in which
engagement of an actuator on the syringe is prevented. This assists in
preventing damage to the syringe prior to actuation of the
injection device.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

There is provided herein an injection device, comprising:
a housing adapted to receive a syringe having a discharge nozzle, the syringe
being
movable within the housing along a longitudinal axis from a retracted position
in which the
discharge nozzle is contained within the housing and an extended position in
which the
discharge nozzle of the syringe extends from the housing through an exit
aperture;
an actuator;
a drive adapted to be acted upon by the actuator an in turn act upon the
syringe to
advance it from its retracted position to its extended position and discharge
its contents
through the discharge nozzle;
a syringe carrier adapted to support the syringe as it is advanced;
a return spring that biases the syringe from the extended position to the
retracted
position, wherein the return spring acts on the syringe via the syringe
carrier; and
a locking mechanism between the syringe carrier and the drive to inhibit
movement
of the syringe carrier and syringe towards the exit aperture.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An auto-injector with an improved locking mechanism for ease of use is
provided. The device
comprises a syringe having a discharge nozzle moveably housed in a housing. In
a retracted
position the discharge nozzle is contained within the housing and in an
extended position the
discharge nozzle extends from the housing through an exit aperture. There is
an actuator acting
on a drive, which in turn acts on the syringe to advance it from its retracted
position to its
extended position, to discharge its contents. A locking mechanism is moveable
from an engaged
position in a direction into the housing at the exit aperture into a
disengaged position. When in
the engaged position, the locking mechanism prevents actuation of the device;
while in the
disengaged position, it permits actuation of the device. The locking mechanism
comprises a
contact surface extending over or around the rim of the exit aperture.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device comprises an actuator adapted when actuated to cause commencement of an injection sequence; a locking mechanism adapted to be moved between a locked position in which the locking mechanism prevents the actuator from being actuated, and an unlocked position in which the actuator can be actuated to cause commencement of the injection sequence. An indicator is configured to provide a visual indication of whether the locking mechanism is in its locked position or in its unlocked position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

Provided herein are anti-LTBR multispecific binding molecules, nucleic acids encoding the anti-LTBR multispecific binding molecules, vectors comprising the nucleic acids, host cells comprising the vectors, and pharmaceutical compositions comprising the anti-LTBR multispecific binding molecules. Also provided are methods of treating cancer in a subject in need thereof, the methods comprising administering the pharmaceutical compositions disclosed herein.

Classes IPC  ?

• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61P 35/00 - Agents anticancéreux
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
• C07K 16/46 - Immunoglobulines hybrides
• C12N 15/13 - Immunoglobulines

Classes IPC  ?

• A61B 17/06 - AiguillesSupports ou empaquetages pour aiguilles ou matériaux de suture

Abrégé

The present invention concerns an injection device (110) with a housing (112)
adapted to receive a syringe (114) having a discharge nozzle (118), the
housing having an indicator opening (113). There is a trigger (111) and a
forward drive (132) arranged to act upon the syringe on actuation of the
trigger to advance the syringe form a retracted position to an extended
position thereby discharging the contents of the syringe through the discharge
nozzle. A support member (122) is in contacting juxtaposition with the housing
and a return drive (126) is supported by the support member and arranged to
act upon the syringe after the contents of the syringe has been discharged so
that the syringe can be withdrawn from the extended position to the retracted
position. Advantageously, the support member is arranged in the housing so
that the second drive does not obscure an inspection of the contents of the
syringe through the indicator opening. Hence, it can be clearly determined
whether the contents of the syringe have been expelled from the syringe.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (110) is described having a housing (112) and a housing
closure means (130). The injection device (110) houses a syringe (114) having
a needle (118) which is sealed by a boot (120). The housing closure means
(130) is arranged so that the boot can be connected to the housing closure
means simply, but cannot be removed from the housing closure means. The
housing and housing closure means are arranged so that upon rotation of the
housing closure means, the housing closure means is moved axially away from
the housing and the boot and the boot is removed from the syringe. The
injection device is simple to use and manufacture.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (210) is described. A housing (212) receives a syringe and
includes a return spring (226) for biasing the syringe from an extended
position in which its needle (218) extends from the housing to a retracted
position in which the it does not. A drive spring (230) acts on a first drive
element (232) and a second drive element (234) acts upon the syringe to
advance it from its retracted position to its extended position and discharge
its contents through the needle. The first drive element is capable of
movement relative to the second once a nominal decoupling position has been
reached. A release mechanism is activated when the-first drive element is
further advanced to a nominal release position, to release the syringe (214)
from the action of the drive spring, whereupon the return spring restores the
syringe to its retracted position. A locking mechanism (337, 375) confines the
returned syringe in its retracted position.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (110) is provided which includes a syringe (122) having a
discharge nozzle (118). The syringe is movable between a retracted position in
which the discharge nozzle is contained within the housing and an extended
position in which the discharge nozzle extends from the housing. A trigger
(114) is activatable to allow the contents of the syringe to be discharged
through the discharge nozzle. There is also a releasable locking mechanism
(116) which, when engaged, prevents the trigger from moving into an active
position. The trigger includes a first portion (150) having a cut-out (152)
which extends from a first end of the trigger in a direction substantially
parallel to the first axis (101). The releasable locking mechanism includes a
protrusion (154) along a second axis (181) for communicating with the first
portion of the trigger when the releasable locking mechanism is engaged and
for communicating with the cut-out when the releasable locking mechanism is
disengaged. Such an injection device provides improved protection against
accidental activation of the trigger.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device (110) comprises a housing (112) having a syringe (114)
with a discharge nozzle (118) . The syringe is movable between a retracted
position in which the discharge nozzle is contained within the housing and an
extended position in which the discharge nozzle extends from the housing.
There is a syringe cap (180) for enclosing the discharge nozzle. The syringe
cap is removable from the syringe by rotation relative to the syringe. A
syringe carrier (150) in the housing is adapted to restrain rotation of the
syringe relative to the housing as the cap is removed.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (110) comprises a housing (112) adapted to receive a
syringe (122) having a discharge nozzle (118) , an actuator (114) and a drive
(120) acted upon by the actuator which acts upon the syringe to advance it
from a retracted position in which the discharge nozzle is contained within
the housing to an extended position in which the discharge nozzle extends from
the housing. There is a locking mechanism (HS) in communication with the
actuator and activatable to be moved from a locked position in which the
actuator is prevented from releasing the drive to an unlocked position in
which the actuator is operable to act upon the drive to advance the syringe.
The locking mechanism or the housing includes integrally formed biasing means
(210) adapted to return the locking mechanism to a locked position when it is
not activated. There is no need for separate springs to be used to bias the
releasable locking mechanism out of the housing.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

A needle assembly (10; 210) for a prefilled injection syringe is described. A
needle holder (12; 212) has a needle (14; 214) secured to it and is adapted to
be secured to a syringe barrel of the injection syringe. A needle sheath (16;
216) has a distal end forming a releasable sterile seal with the needle holder
(12; 212), and surrounds and shields the needle (14; 214) . A needle seal (18;
218) surmounts the needle tip and is arranged at least in part in the proximal
end of the needle sheath (16; 216) and closed off by a closure element (20;
220) . A closure connection between the closure element (20; 220) and the
needle sheath (16; 216) is configured as a non-releasable and sterile barrier
(54; 254) produced by means of bonding or welding.

Classes IPC  ?

• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device (110) is described having a housing (112) that receives a
syringe (114) having a sealed boot (123) that covers its needle (118). A
releasable locking mechanism retains the syringe (114) in its retracted
position. A sleeve (119) projects from the exit aperture (128) and can be
depressed to release the locking mechanism. A removable threaded cap (111)
closes the housing (112), covers the exit aperture (128) and the sleeve (119),
thus preventing the locking mechanism from being released, and engages the
boot (123) on the syringe (114). When the cap (111) is removed, it takes the
boot (123) with it, no longer closes the exit aperture (128) and no longer
prevents the locking mechanism from being released. Then, the locking
mechanism can be released and the injection cycle begun.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device is provided having a housing and a drive that acts upon a
syringe when released by a
trigger. The trigger is rotatable from a rest position, which causes the drive
to be retained, to an active
position, in which it no longer causes the drive to be retained. A damping
means is arranged in
conjunction with the trigger to prevent accidental actuation of the device. A
viscous fluid is provided as a
damping means and positioned between an upper surface of the trigger and an
inner surface of the
housing. Such an injection device provides improved reliability and resilience
to damage caused by
impact forces, for example, when the device is dropped onto a hard surface.
The trigger is also retained in
its active position after actuation, indicating that the device has been used.
Additionally, the noise
production by the operation of the trigger, which may be distressing to a
user, is reduced.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

There is described herein an improved injection device designed to overcome
mechanical
failures of components and/or syringe breakage during operation, and other
problems. The
improved injection comprising: a housing adapted to receive a syringe having a
discharge
nozzle, so that the syringe is movable between a retracted position in which
the discharge
nozzle is contained within the housing and an extended position in which the
discharge
nozzle extends from the housing through an exit aperture; a drive that acts
upon the syringe
to advance it from its retracted position to its extended position and
discharge its contents
through the discharge nozzle, a syringe carrier that advances with the
syringe; a restraining
component that restrains the advancement of the syringe carrier as the syringe
reaches its
extended position; and a damping element that acts between the syringe carrier
and the
restraining component.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device (110) is described having a housing (112) and a cap (130). The injection device (110) houses a syringe (114) having a needle which is sealed by a boot (118). The cap (130) is arranged so that the boot (118) can be connected to the cap (130) whilst exerting a minimal force on the syringe, but cannot be removed from the cap (130) without applying a significantly greater force to the syringe. The housing (112) and cap (130) are arranged so that upon removal of the cap (130) from the housing (112), the boot (118) is removed from the syringe (114).

Classes IPC  ?

• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device is described having a housing, a drive element and a
syringe carrier. The
housing is adapted to receive a syringe having a discharge nozzle at a first
end, the syringe
being movable between a retracted position and an extended position in which
it extends
through an exit aperture. The drive element includes a syringe piston, which
acts directly
upon the syringe to advance it from its retracted position to its extended
position and
discharge its contents. The syringe carrier carries the syringe as it is
advanced and has a first
end through which the discharge nozzle extends. The syringe carrier includes,
at its second
end, means for restricting movement of the syringe relative to the syringe
carrier to the
second end whilst allowing some movement of the syringe in the direction from
the first end
to the second end of the syringe carrier.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device comprises a locking mechanism (171-173) between a syringe
carrier (127) and an end cap (111)
of the injection device. The cap is formed in such a way to inhibit movement
of the syringe carrier and syringe towards an exit
aperture of the injection device when the drive has not been removed from the
injection device. On removal of the cap, the locking
mechanism is no longer so engaged and the syringe and syringe carrier can move
towards the exit capture. This assists in preventing
damage to the syringe prior to actuation of the injection device.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device comprises a locking-mechanism in the form of two buttons
(17) located on the front end of the
injection device. In an engaged position, the locking mechanism prevents
removal of a cap (111) from the injection device and,
in a disengaged position, prevents movement of a syringe carrier (127) holding
a syringe but permits removal of the cap from the
housing. This assists in preventing damage to the syringe prior to actuation
of the injection device.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device comprises a locking mechanism (171a, 171b) between a
syringe carrier (128) and an end cap
(111) of the injection device. The cap is formed in such a way to inhibit
movement of the syringe carrier and syringe towards an exit
aperture of the injection device when the cap is located in its closed
position on the injection device. A needle shield (123) located
on the needle of the syringe is removed by rotating the cap whilst the locking
mechanism remains engaged. On removal of the cap,
the locking mechanism is no longer so engaged and the syringe and syringe
carrier can move towards the exit aperture. This assists
in preventing damage to the syringe prior to actuation of the injection
device.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection- system is provided which comprises an injection device (210) and
a base station (240) which connects
to the injection device. The base station resets the actuator mechanism in the
injection device from its actuated state to its unactuated
state so that further actuation of the actuator mechanism can take place.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

An injection device that retracts automatically is provided. A housing
includes means for
biasing the syringe from an extended position to a retracted position. The
device includes an
actuator and a drive, one comprising a flexible arm that engages with a drive
surface on the
other, allowing the actuator to prevent the former from moving relative to the
latter. The arm
is prevented from disengaging until the drive has been advanced to a nominal
release
position, whereupon the arm disengages, allowing the actuator to move relative
to the drive
and thus releasing the syringe from the action of the actuator, whereupon the
biasing means
restores the syringe to its retracted position. The arm is biased toward a
position at which it
engages the drive surface and the action of the actuator causes it to move
against its bias, thus
disengaging it from the drive surface.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles

Abrégé

Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients and a capacitance are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non -blood sample based on characteristics of the sample (e.g., amount of interferent present, reaction kinetics, and/or capacitance). The method can also include calculating a discrimination criteria based upon these characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non -blood sample are also provided herein.

Classes IPC  ?

• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
• G01N 27/327 - Électrodes biochimiques
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

An analytical test strip ("ATT") for use with a test meter includes a first insulating layer, with a first insulating layer upper surface, and a first electrically conductive layer ("ECL") disposed thereon. The first ECL includes a first electrode portion ("EP") and an electrical contact pad in electrical communication with the first EP. The ATT also includes a patterned spacer layer disposed above the first ECL that includes (i) a distal portion defining a bodily fluid sample-receiving chamber therein that overlies the first EP and (ii) an insulating proximal portion with an upper surface having a second ECL disposed thereon. The second ECL includes an interlayer contact portion and an electrical contact pad. A third ECL of the ATT includes a second EP and a proximal portion that overlies the interlayer contact portion. The second EP is disposed overlying and exposed to the sample-receiving chamber in an opposing relationship to the first EP.

Classes IPC  ?

• C12Q 1/00 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions
• G01N 27/327 - Électrodes biochimiques
• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

An injection device for delivering an injection comprises a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end; and a release mechanism comprising an impediment, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede the delivery of the injection, and a second position, in which the impediment is in a non-impeding position so as to not impede the delivery of the injection, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

An injection device comprises an actuator adapted when actuated to cause commencement of an injection sequence; a locking mechanism adapted to be moved between a locked position in which the locking mechanism prevents the actuator from being actuated, and an unlocked position in which the actuator can be actuated to cause commencement of the injection sequence. The locking mechanism comprises a contact portion which in the locked position of the locking mechanism projects against the actuator. The contact portion comprises a curved surface.

Classes IPC  ?

• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique

Abrégé

A method for determining a diffusion feature of a fluidic sample using redox reactions in an electrochemical cell that has at least two electrodes, wherein the first electrode has at least one redox mediator at its surface or in close vicinity of its surface, and the second electrode has an electrode surface free of the redox mediator(s) in the beginning of a test, the method comprising: applying an electric potential to a fluidic sample in the electrochemical cell to initiate redox reactions at the two electrode surfaces; measuring current associated with the applied potential as a function of time, and using a measurement point on a transient part of the measured current at or after a turning point and its associated time to determine the diffusion feature.

Classes IPC  ?

• G01N 27/327 - Électrodes biochimiques

Abrégé

An injection device for delivering an injection comprises a housing having a
longitudinal axis, a
proximal end and a distal end, the housing being arranged such that the
injection is delivered from
its distal end; and a release mechanism comprising an impediment, the release
mechanism being
moveable between a first position, in which the impediment is in an impeding
position so as to
impede the delivery of the injection, and a second position, in which the
impediment is in a non-
impeding position so as to not impede the delivery of the injection, wherein
the force required to
move the release mechanism from the first position to the second position
varies with the distance
moved by the release mechanism, the variation in the force required with
distance being
represented by a force profile, which is non-linear.

Classes IPC  ?

• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
• A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
• A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe

Abrégé

The present inventions relates to bioresorbable sealing powder comprising: (a) water-soluble electrophilic polymer carrying at least 3 reactive electrophilic groups that are capable of reacting with amine groups under the formation of a covalent bond; (b) water-soluble nucleophilic cross-linker carrying at least 2 reactive nucleophilic groups that, in the presence of water, are capable of reacting with the reactive electrophilic groups of the electrophilic polymer under the formation of a covalent bond between the electrophilic polymer and the nucleophilic cross-linker; (c) water-absorbing particles containing at least 50% by weight of said water-absorbing particles of water-insoluble polymer containing reactive nucleophilic groups; (d) water-soluble dispersant that is solid at 20°C, said water-soluble dispersant being selected from monosaccharides, disaccharides, oligosaccharides, sugar alcohols and combinations thereof. wherein the components (a), (b), (c) and (d) may be contained in the same particles or in different particles. The invention also provides a method of preparing the aforementioned bioresorbable sealing powder Further provided are (i) a device for powder application comprising the bioresorbable sealing powder, (ii) a biocompatible, flexible, hemostatic sheet comprising the bioresorbable sealing powder and (iii) a kit of parts for preparing a sealing suspension, said kit comprising the bioresorbable powder, and (iv) a sealing suspension containing the bioresorbable sealing powder.

Classes IPC  ?

• A61L 24/00 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie
• A61L 26/00 - Aspects chimiques des bandages liquides ou utilisation de matériaux pour les bandages liquides

Classes IPC  ?

• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
• A61F 13/02 - Bandages ou pansements adhésifs