Abrégé

A stereospecific synthesis process for tretinoin compounds comprises the following steps: using substituted triphenyl phosphine salt and β-formyl crotonic acid as raw material to carry out WITTIG reaction under the action of alkali; then adjusting the pH of the reaction liquid to 5-10; adding palladium compound or rhodium compound to carry out isomerization directly and obtain tretinoin compounds with desired configuration. The product yield of the process is high and the intermediate product in the reaction dose not need to be separated. The process is easy to operate and can save the production cost and as well is suitable for industrial production.

Classes IPC  ?

• C07C 61/16 - Composés non saturés
• C07C 53/134 - Composés saturés ne comportant qu'un groupe carboxyle lié à un atome de carbone acyclique ou à un atome d'hydrogène contenant des cycles monocycliques
• C07C 51/00 - Préparation d'acides carboxyliques, de leurs sels, halogénures ou anhydrides

Abrégé

A stereospecific synthesis process for tretinoin compounds comprises the following steps: using substituted triphenyl phosphine salt and β-formyl crotonic acid as raw material to carry out WITTIG reaction under the action of alkali; then adjusting the pH of the reaction liquid to 5～10; adding palladium compound or rhodium compound to carry out isomerization reaction directly and obtain tretinoin compounds with desired configuration. The product yield of the process is high and the intermediate product in the reaction does not need to be separated. The process is simple and can save the production cost and is suitable for industrial production.

Classes IPC  ?

• C07C 403/20 - Dérivés du cyclohexane ou d'un cyclohexène, comportant une chaîne latérale avec une partie non saturée d'au moins quatre atomes de carbone en ligne, ladite partie étant directement attachée aux cycles cyclohexane ou cyclohexène, p. ex. vitamine A, bêta-carotène, bêta-ionone ayant des chaînes latérales substituées par des groupes carboxyle

Abrégé

Disclosed is a process for separating 5-hydroxy-4-methyl-2-5[H]-furanone produced by glyoxylic acid and n-propionaldehyde as starting materials, characterized in that the extraction separation is carried out with an organic solvent in the presence of mineral salts.

Classes IPC  ?

• C07C 7/10 - Purification, séparation ou stabilisation d'hydrocarburesEmploi d'additifs par extraction, c.-à-d. purification ou séparation d'hydrocarbures liquides à l'aide de liquides
• C07D 307/58 - Un atome d'oxygène, p. ex. buténolide