A TMS coil assembly for magnetic stimulation of a brain region of a treated subject. The TMS coil assembly comprising one or more coil assemblies, each of which comprising adjacently located, or spaced-apart, flexible winged-coil structures configured to adjustably deform along a tilt axis passing between the winged-coil structures to apply a desired tilt angle between the winged-coil structures for them to conform to curved surfaces of a head of a treated subject and bring substantial loop portions of the winged-coil structures into direct contact with the curved surfaces of the head, to thereby maximize the loop portions that are tangential to the curved surfaces of the head and minimize the loops portion that are non-tangential to the curved surfaces. A fastening arrangement can be used to maintain the desired tilt angle between the winged-coil structures when placed on the head of the treated subject during a TMS procedure, to thereby maximize strength of electric field thereby induced into the head.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Surgical and medical apparatus and instruments, namely, transcranial magnetic stimulation apparatus for treatment of brain disorders Medical services for treatment of brain disorders
4.
DEVICE AND METHOD FOR TRANSCRANIAL MAGNETIC STIMULATION
A TMS coil assembly for magnetic stimulation of a brain region of a treated subject. The TMS coil assembly comprising one or more coil assemblies, each of which comprising adjacently located, or spaced-apart, flexible winged-coil structures configured 5 to adjustably deform along a tilt axis passing between the winged-coil structures to apply a desired tilt angle between the winged-coil structures for them to conform to curved surfaces of a head of a treated subject and bring substantial loop portions of the winged- coil structures into direct contact with the curved surfaces of the head, to thereby maximize the loop portions that are tangential to the curved surfaces of the head and minimize the 10 loops portion that are non-tangential to the curved surfaces. A fastening arrangement can be used to maintain the desired tilt angle between the winged-coil structures when placed on the head of the treated subject during a TMS procedure, to thereby maximize strength of electric field thereby induced into the head.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
H01F 27/30 - Fixation ou serrage de bobines, d'enroulements ou de parties de ceux-ci entre euxFixation ou montage des bobines ou enroulements sur le noyau, dans l'enveloppe ou sur un autre support
5.
Device and method for real-time closed-loop brain stimulation
Brain stimulation techniques are disclosed, utilizing a brain state monitoring and stimulating component having at least one processor and memory, and a digital signal processing unit configured and operable to predict at least one brain state about to occur in a brain of a treated subject based on data or signals indicative of at least one brain state of the treated subject. The digital signal processing unit can be configured to generate based on the predicted at least one brain state stimulation data for adjusting, regulating or triggering, brain stimulation signals applied to the brain of the treated subject. The at least one processor, memory, and digital signal processing unit are embedded in some embodiments in a single hardware device.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
An electromagnetic coil assembly for inducing electromagnetic fields in a head region of a treated subject, the assembly comprising windings configured to define an applicatory coil portion configured for placement in close proximity to the head to induce the electromagnetic fields, and an elevated coil portion passing relatively remote from the head and configured such that electromagnetic fields thereby produced are generated substantially remote from the head, thereby allowing directing the electromagnetic fields generated by the applicatory coil portion substantially accurately to desired inner regions of the head. A support structure is used to enclose and immobilize at least a portion of the windings, while enabling elastic movement of other portions of the windings that are not held by the support structure, to thereby enable size adjustment of the coil to fit over a region of a head of the treated subject.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Surgical and medical apparatus and instruments for treatment of brain disorders, namely, microelectronic neurostimulation and neuromodulation apparatus for the treatment of mental health disorders, apparatus for transcranial magnetic stimulation (1) Medical services for treatment of brain disorders;
8.
Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier
Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
9.
DEVICE AND METHOD FOR REAL-TIME CLOSED-LOOP BRAIN STIMULATION
Brain stimulation techniques are disclosed, utilizing a brain state monitoring and stimulating component having at least one processor and memory, and a digital signal processing unit configured and operable to predict at least one brain state about to occur in a brain of a treated subject based on data or signals indicative of at least one brain state of the treated subject. The digital signal processing unit can be configured to generate based on the predicted at least one brain state stimulation data for adjusting, regulating or triggering, brain stimulation signals applied to the brain of the treated subject. The at least one processor, memory, and digital signal processing unit are embedded in some embodiments in a single hardware device.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
An electromagnetic coil assembly for inducing electromagnetic fields in a head region of a treated subject, the coil assembly comprising a plurality of windings configured to define an applicatory coil portion configured for placement in close proximity to the head of the treated subject to induce the electromagnetic fields, and an elevated coil portion passing relatively remote from the head of the treated subject and configured such that electromagnetic fields thereby produced are generated substantially remote from the head of the treated subject to prevent them from interfering with the electromagnetic fields generated by the applicatory portion of the coil, thereby allowing directing the electromagnetic fields generated by the applicatory coil portion substantially accurately to desired inner regions of the head of the treated subject. A support structure is used to enclose and immobilize at least a portion of the windings of the coil, while enabling elastic movement of other portions of the windings that are not held by the support structure, to thereby enable size adjustment of the coil to fit over a region of a head of the treated subject.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
11.
METHODS FOR TREATING OBSESSIVE COMPULSIVE DISORDER
Devices for treating obsessive compulsive disorder and methods for treating subjects afflicted with obsessive compulsive disorder are presented herein. In a particular aspect, the devices described herein are used to treat obsessive compulsive disorder in a subject in which personalized provocation related to at least one of obsessions or compulsions of the subject has been induced. In another aspect, methods for treating subjects afflicted with obsessive compulsive disorder are used to treat a subject in which personalized provocation related to at least one of obsessions or compulsions of the subject has been induced.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
12.
Enhanced spatial summation for deep-brain transcranial magnetic stimulation
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
Inventeur(s)
Schneider, M. Bret
Abrégé
Methods of stimulating a target deep brain region using multiple Transcranial Magnetic Stimulation (TMS) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying TMS so that the applied TMS induces spatial summation and thereby modulation of the target deep brain region.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Apparatus and methods are described for use with electrophysiological signal detecting electrodes (14), and a transcranial magnetic stimulation device (10). A computer processor (16) drives the transcranial stimulation device to apply one or more pulses of transcranial magnetic stimulation to a subject. Within a given time period of applying one of the one or more pulses of transcranial magnetic stimulation to the subject, the computer processor detects an electrophysiological signal of the subject, using the electrophysiological signal detecting electrodes (14). At least partially in response thereto, the computer processor predicts an outcome of treating the subject for a neuropsychiatric condition, using a given therapy, and generates an output on an output device (18) in response to the predicted outcome. Other applications are also described.
A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
16.
Central base coils for deep transcranial magnetic stimulation
A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
19.
CIRCULAR COILS FOR DEEP TRANSCRANIAL MAGNETIC STIMULATION
A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
20.
CENTRAL BASE COILS FOR DEEP TRANSCRANIAL MAGNETIC STIMULATION
A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
21.
UNILATERAL COILS FOR DEEP TRANSCRANIAL MAGNETIC STIMULATION
A coil for transcranial magnetic stimulation which is location-specific for unilateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements and return elements are distributed on one side of a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
22.
Central base coils for deep transcranial magnetic stimulation
A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
A coil for transcranial magnetic stimulation which is location-specific for unilateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements and return elements are distributed on one side of a central axis of the coil.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
26.
TRANSCRANIAL MAGNETIC STIMULATION TO MODULATE THE BLOOD BRAIN BARRIER
Transcranial magnetic stimulation (TMS) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep TMS coil may be placed on a head in a vicinity of a tumor, for example. A series of magnetic pulses is provided to the brain with a tailored stimulation protocol. In one of many possible clinical applications, a pharmaceutical substance may be introduced during a time frame before, during or after providing the magnetic pulses to treat a tumor in the brain.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
27.
Transcranial magnet stimulation of deep brain targets
The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
28.
Shaped coils for transcranial magnetic stimulation
Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
Systems and methods for modulating deep brain target regions using an array of TMS electromagnets, wherein each TMS electromagnet stimulates the target at a level that is below motor threshold (MT). Neurological disorders (or disorders having neurological effects) may be treated by sub-MT stimulation of deep-brain targets from an array of TMS electromagnets.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
Methods and systems for modeling and displaying magnetic field intensities during Transcranial Magnetic Stimulation (TMS) are described, particularly methods and system for modeling and displaying TMS using overlapping magnetic fields to stimulate deep brain regions.
G06F 7/60 - Méthodes ou dispositions pour effectuer des calculs en utilisant une représentation numérique non codée, c.-à-d. une représentation de nombres sans baseDispositifs de calcul utilisant une combinaison de représentations de nombres codées et non codées
G06G 7/48 - Calculateurs analogiques pour des procédés, des systèmes ou des dispositifs spécifiques, p. ex. simulateurs
The treatment of specific neurological and psychiatric illnesses using Transcranial Magnetic Stimulation (TMS) requires that specific neuroanatomical structures are targeted using specific pulse parameters. Described herein are methods of positioning and powering TMS electromagnets to selectively stimulate a deep brain target region while minimizing the impact on non-target regions between the TMS electromagnet and the target. Use of these configurations may involve a combination of physical, spatial and/or temporal summation. Specific approaches to achieving temporal summation are detailed.
A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
32.
Transcranial magnetic stimulation system and methods
A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.
