Abrégé

The present disclosure provides implant materials comprising platelet-derived growth factor and a biocompatible matrix that are useful for bone repair, including bone fusion procedures and fracture repair.

Classes IPC  ?

• A61L 27/42 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques

Abrégé

The present disclosure provides improved compositions comprising a solution of a platelet-derived growth factor and a biocompatible matrix that are useful for bone fusion procedures, such as spine fusion procedures. The compositions advantageously comprise a the PDGF solution and biocompatible matrix in about a 2:1 volume to weight (mL:g) ratio such that the compositions can be readily applied to a site of bone fusion using a syringe or cannula. In particular embodiments, the composition is useful in conjunction with a spine fusion cage in a spine fusion procedure. The present disclosure also provides methods of performing fusion procedures, such as spine fusion, and kits for fusion procedures.

Classes IPC  ?

• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 27/42 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
• A61L 27/24 - Collagène

Abrégé

The present disclosure provides improved compositions comprising a solution of a platelet-derived growth factor and a biocompatible matrix that are useful for bone fusion procedures, such as spine fusion procedures. The compositions advantageously comprise a the PDGF solution and biocompatible matrix in about a 2:1 volume to weight (mL:g) ratio such that the compositions can be readily applied to a site of bone fusion using a syringe or cannula. In particular embodiments, the composition is useful in conjunction with a spine fusion cage in a spine fusion procedure. The present disclosure also provides methods of performing fusion procedures, such as spine fusion, and kits for fusion procedures.

Classes IPC  ?

• A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 27/56 - Matériaux poreux ou cellulaires
• A61L 27/42 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice inorganique
• A61F 2/28 - Os
• A61B 17/70 - Dispositifs de mise en position ou de stabilisation de la colonne vertébrale, p. ex. stabilisateurs comprenant un liquide de remplissage dans un implant
• A61B 17/88 - Moyens ou procédés pour implanter ou pour extraire des dispositifs de fixation interne

Abrégé

The present disclosure relates to a method for detecting the presence of PDGF neutralizing antibodies in a serum sample, comprising contacting a population of cells with i) a serum sample, and ii) PDGF, wherein the cells comprise a PDGF receptor; and detecting an amount of a biomarker in the population of cells, wherein the biomarker indicates binding of the PDGF with the PDGF receptor. The present disclosure also relates to a method of determining the presence of PDGF neutralizing antibodies in a subject who has received or is currently receiving a treatment comprising PDGF.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

The present invention provides compositions and methods for promoting fusion of bones in spine fusion procedures. In some embodiments, a method of performing a spine fusion procedure comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to a site of desired spine fusion.

Classes IPC  ?

• A61B 17/58 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulationsDispositifs spécialement adaptés à cet effet pour ostéosynthèse, p. ex. plaques, vis ou matériels de fixation