Embodiments of the present invention provide a computer-implemented method of determining a presence of a β-emitting radionuclide in a migratory environment, the method comprising determining (210) an indication of energy distribution of ionizing radiation incident upon a scintillation detector proximal to the migratory environment, determining (220) a ratio of a proportion of the energy distribution of ionizing radiation in a first energy range to a proportion of the energy distribution at a predetermined energy, and determining (230) the presence of the β-emitting radionuclide in the migratory environment in dependence on the ratio.
G01T 1/169 - Exploration, localisation de surfaces contaminées
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
A novel material is described, the structure of which is such that it may be termed a conjugated microporous polymer. The material may be prepared by an industrially attractive, one-pot synthesis. The material exhibits advantageous electrochemical properties, making it particularly well-suited for use in battery applications.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
C08G 61/12 - Composés macromoléculaires contenant d'autres atomes que le carbone dans la chaîne principale de la macromolécule
C09D 165/00 - Compositions de revêtement à base de composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principaleCompositions de revêtement à base de dérivés de tels polymères
C08L 65/00 - Compositions contenant des composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principaleCompositions contenant des dérivés de tels polymères
C08G 61/00 - Composés macromoléculaires obtenus par des réactions créant une liaison carbone-carbone dans la chaîne principale de la macromolécule
An example presented herein provides a method of self-evolving deep machine learning on at least one apparatus, the method comprising: performing operations comprising: receiving, by a first apparatus, input data; transmitting the input data to a pre-trained machine learning module of the first apparatus; encoding, by the pre-trained machine learning module, the input data; grouping, by the first apparatus, the encoded input data into a plurality of first clusters based on a similarity of individual data points of the input data; providing, by the first apparatus for each of the plurality of first clusters, a first representative example; receiving, by the first apparatus, object input data corresponding to a request for object identification; encoding, by the pre-trained machine learning module, the object input data; identifying, by the first apparatus, whether one of the first representative examples corresponds to the encoded object input data based on a degree of association of the encoded object input data with each first cluster of the plurality of first clusters; and grouping, by the first apparatus, the encoded object input data into a cluster based on the degree of association of the encoded object input data with each first cluster of the plurality of first clusters, such that the encoded object input data is used in future implementation of the machine learning.
G06F 18/2413 - Techniques de classification relatives au modèle de classification, p. ex. approches paramétriques ou non paramétriques basées sur les distances des motifs d'entraînement ou de référence
G06V 10/762 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant le regroupement, p. ex. de visages similaires sur les réseaux sociaux
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
4.
METHOD OF MEASURING CREATININE CONCENTRATION AND SENSOR
A method of measuring a concentration of creatinine in a sample. The method includes the steps of: a) contacting the sample with a composition comprising an iron(ll) or an iron(lll) species, wherein the composition has a pH of at least 10; b) measuring changes in electrochemistry or UV-visible light absorbance in the composition after contacting the sample with the composition in step a); and c) determining the concentration of creatinine in the sample from the changes in the composition measured in step b). This method may be lower in cost and/or simpler to operate than the prior art. A sensor comprising an electrode and a basic composition comprising an iron species suitable for carrying out the method is also described.
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
G01N 33/70 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir la créatine ou la créatinine
Compound(s) according to formula (I), L1-R-L2; wherein L1 is a ligand capable of binding to kinesin family member C1 (KIFC1) as defined herein, R is a linker group with a chain length having an integer of at least 3 atoms; and L2 is a ligand capable of binding E3 ligase. Also, pharmaceutical compositions comprising said compound(s) and said compounds for use as a medicament, in particular, for use in the treatment of cancer.
C07D 409/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 47/50 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament
6.
METHOD AND APPARATUS FOR DETERMINING ATTRIBUTES OF A SOURCE OF RADIATION
Embodiments of the present invention provide a computer-implemented method of determining a location of a source (210) of radiation within a medium (200), the method comprising determining an indication of energy distribution of ionizing radiation incident upon a scintillation detector (320) at each of a plurality of locations of the detector within the medium, calibrating (630) one of a plurality first models to the indication of energy distribution of ionizing radiation determined at each of the plurality of locations within the medium (200), wherein each first model comprises a first portion representative of a photopeak of ionizing radiation from a first radioactive source, to determine a photopeak portion of the energy distribution at each respective location, and calibrating (920) a second model comprising an asymmetric function to the photopeak portion of the energy distribution at the plurality of locations to determine the location of the source (210) of radiation within the medium (200).
G01T 1/167 - Mesure du contenu radioactif des objets, p. ex. contamination
G01T 1/36 - Mesure de la distribution spectrale des rayons X ou d'une radiation nucléaire
G01V 5/06 - Prospection ou détection au moyen de rayonnement ionisant, p. ex. de la radioactivité naturelle ou provoquée spécialement adaptée au carottage pour détecter des minerais à radioactivité naturelle
Aspects of the invention relate to a glucose concentration measuring device and a method of measuring glucose concentration. The device comprises at least one transmitter, at least one receiver, and at least one controller. The at least one transmitter is configured to emit a first electromagnetic radiation signal having a first wavelength and a second electromagnetic radiation signal having a second wavelength to illuminate an in vivo blood sample, and the at least one receiver is configured to receive the first and second electromagnetic radiation signals after the electromagnetic radiation signals have illuminated said blood sample. The at least one controller is configured to generate first spectral data indicative of glucose absorbance based on the first received electromagnetic radiation signal and second spectral data indicative of water absorbance based on the second received electromagnetic radiation signal, and determine a glucose concentration measurement in dependence on the first and second spectral data.
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1455 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des capteurs optiques, p. ex. des oxymètres à photométrie spectrale
There is provided a logic gate comprising a semiconductor device. The semiconductor device includes a charge reservoir layer disposed between a first charge accepting layer and a second charge accepting layer. The first charge accepting layer defines a first current flow path that is connected to a common output contact at one end and a drive contact at the other end. The second charge accepting layer defines a current flow path that is connected to the common output contact at one end and a ground contact at the other end. The charge reservoir layer comprises a potential well having a lowest energy state for mobile charge carriers that is at a lower energy than the lowest energy state for mobile charge carriers of both the first and second charge accepting layers. The logic gate further comprises a control gate and a ground electrode that are separated from the charge accepting layers by non-conducting layers. The control gate and the ground electrode are configured to apply an input voltage across the semiconductor device, such that mobile charge carriers confined within the charge reservoir layer are transferred to the first charge accepting layer at a first applied input voltage and transferred to the second charge accepting layer at a second applied input voltage.
H01L 21/8252 - Fabrication ou traitement de dispositifs consistant en une pluralité de composants à l'état solide ou de circuits intégrés formés dans ou sur un substrat commun avec une division ultérieure du substrat en plusieurs dispositifs individuels pour produire des dispositifs, p.ex. des circuits intégrés, consistant chacun en une pluralité de composants le substrat étant un semi-conducteur, en utilisant une technologie III-V
H01L 27/06 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant une pluralité de composants individuels dans une configuration non répétitive
H01L 27/088 - Dispositifs consistant en une pluralité de composants semi-conducteurs ou d'autres composants à l'état solide formés dans ou sur un substrat commun comprenant des éléments de circuit passif intégrés avec au moins une barrière de potentiel ou une barrière de surface le substrat étant un corps semi-conducteur comprenant uniquement des composants semi-conducteurs d'un seul type comprenant uniquement des composants à effet de champ les composants étant des transistors à effet de champ à porte isolée
H01L 29/778 - Transistors à effet de champ avec un canal à gaz de porteurs de charge à deux dimensions, p.ex. transistors à effet de champ à haute mobilité électronique HEMT
The present disclosure relates to paramyxoviruses, in particular attenuated avian avulaviruses (para, ortho and meta), mutated and genetically modified forms, as well as a vaccine formulation comprising an attenuated avian avulavirus and uses/methods of use thereof.
Methods, apparatus, a system, a computer program and a computer-readable data carrier are disclosed. A method comprises providing spectroscopic data associated with at least one microorganism, and obtained via a Raman or Infrared spectroscopy technique, as an input into at least one machine learning module, and responsive to providing the spectroscopic data, providing at least one trained machine learning model, wherein the trained machine learning model is configured to identify at least one microorganism in a biological sample.
G01N 21/35 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge
An electron gun is disclosed for use in an apparatus, such as a TWT, having a body along which a beam of electrons emitted by the electron gun travels during use. The electron gun comprises a housing for forming a vacuum seal with the body of the apparatus, a cathode disposed within the housing for generating electrons, an anode towards which electrons emitted from the cathode are accelerated and a hole in the anode to permit the accelerated electrons to pass into the body of the apparatus. The cathode is formed as a thermionic cathode assembly comprising a cathode electrode and a heater for heating the cathode electrode and the anode of the electron gun is constituted by the housing.
A semiconductor device comprises a substrate, one or more first III- semiconductor layers, and a plurality of superlattice structures between the substrate and the one or more first layers. The plurality of superlattice structures comprises an initial superlattice structure and one or more further superlattice structures between the initial superlattice structure and the one or more first layers. The plurality of superlattice structures is configured such that a strain-thickness product of semiconductor layer pairs in each superlattice structure of the one or more further superlattice structures is greater than or equal to a strain-thickness product of semiconductor layer pairs in superlattice structure(s) of the plurality of superlattice structures between that superlattice structure and the substrate. The plurality of superlattice structures is also configured such that a strain-thickness product of semiconductor layer pairs in at least one of the one or more further superlattice structures is greater than a strain-thickness product of semiconductor layer pairs in the initial superlattice structure.
There is described herein, a plasma device for the generation of oxygen and nitrogen species (RONS) and methods of generating RONS using the plasma device.
METHYL 2-ALLYL-1 -METHYL-3-OXOINDOLINE-2-CARBOXYLATE AND 9A-ALLYL-1,2,3,9A-TETRAHYDRO-9H-PYRROLO[1,2-A]INDOL-9-ONE DERIVATIVES AND RELATED COMPOUNDS FOR USE AS FLUORESCENT MARKERS FOR LABELLING OF DRUGS, AMINO ACIDS AN PROTEINS
Compounds of formulae (3) and (I) for use as fluorescent markers for labelling an amine containing target drug, an amino acid or a protein. (3) (I) Exemplary compounds are e.g. (II) (III) (IV).
C07D 209/42 - Atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
There is provided a process for tanning animal hide comprising treating an animal hide with at least one tanning agent and exposing the treated hide to a dose of ionising radiation of from 1 to 500 kJ/kg wherein the ionising radiation is in the form of a charged particle beam.
C14C 3/16 - Tannage chimique par agents organiques au moyen d'aldéhydes aliphatiques
C14C 3/30 - Tannage chimique par des moyens physiques combinés avec des moyens chimiques
D06P 1/00 - Procédés généraux de teinture ou d'impression des textiles ou procédés généraux de teinture du cuir, des fourrures ou des substances macromoléculaires solides de toutes formes, classés selon les teintures, les pigments ou les substances auxiliaires utilisés
16.
IMPROVEMENTS RELATING TO ELECTRONIC MEMORY DEVICES
There is provided a memory cell for storing one or more bits of information. The memory cell comprises a semiconductor substrate on which is provided a source terminal, a drain terminal and a channel extending between the source and drain terminals. The memory cell further comprises a control gate and a floating gate, the floating gate being disposed between the control gate and the channel, and the floating gate being electrically isolated from the control gate and the channel by charge barriers and being configured to enable the selective passage of charge carriers into and out of the floating gate, in write and erase operations, to provide at least first and second occupancy states of the floating gate. The channel is arranged to provide a minimum threshold voltage to be applied between the control gate and the substrate for introducing charge carriers into the channel from the substrate to make the channel conductive, the minimum threshold voltage being dependent on the occupancy state of the floating gate, such that a read voltage may be applied between the control gate and the substrate that will provide a conductive channel for a first occupancy state of the floating gate and a non-conductive channel for a second occupancy state of the floating gate.
The present invention relates to compositions which are comprised of therapeutically administrable peptide constructs, or peptide constructs bonded to carrier particles, that are capable of binding to tau protein and which are useful particularly, but by no means exclusively, for the prevention and/or treatment of neurodegenerative diseases characterized by the formation of tau deposits (e.g. neurofibrillary tangles or Pick bodies). The invention has particular application to the prevention and/or treatment of Alzheimer's disease (AD), Chronic Traumatic Encephalopathy (CTE), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD) and some forms of Frontotemporal Dementia (FTD), including Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-17).
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A photosensitive device is provided, which comprises a sensor having at least one sensing element. The at least one sensing element has a core layer and a shell layer of semiconductor materials, the core and shell layers being arranged to form a heterojunction having a type-ll band alignment. The device further comprises a plurality of electrical contacts for applying a voltage across the core layer of the at least one sensing element, and a monitor for measuring the current through the core layer of the at least one sensing element, such that incident radiation is detected by a reduction in the measured current.
H01L 31/0304 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés AIIIBV
H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
H01L 31/112 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par un fonctionnement par effet de champ, p.ex. phototransistor à effet de champ à jonction
A photon detector such as an avalanche photodiode or a single photon avalanche photodiode comprises a semiconductor device comprising an absorber region and a multiplication region. The multiplication region comprises aluminium arsenide antimonide (AIAsSb) and/or aluminium gallium arsenide antimonide (AIGaAsSb). The absorption region comprises indium gallium arsenide antimonide (InGaAsSb) and/or indium arsenide antimonide (InAsSb).
H01L 31/107 - Dispositifs sensibles au rayonnement infrarouge, visible ou ultraviolet caractérisés par une seule barrière de potentiel ou de surface la barrière de potentiel fonctionnant en régime d'avalanche, p.ex. photodiode à avalanche
The present invention relates to modified peptides which are designed to inhibit amylin aggregation and which may be used therapeutically for treating diseases such a type-2 diabetes. There is also provides pharmaceutical formulations comprising the modified peptides, as well as methods of treatment.
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A piezo-electric device comprising a hydrated, polarised cement comprising calcium, aluminium and silicon containing components is disclosed. The device is produced by mixing a cement mixture comprising calcium, aluminium and silicon with water and applying an electric field to the cement during or after curing. The device may be used for example in the development of smart critical physical infrastructure.
The present invention relates to a device comprising a plurality of side-coupled radio frequency cavities. The device comprises multiple sections, each section having a main axial cavity portion and the sections being stacked in an axial direction such that the main axial cavity portions are axially aligned to form a main axial cavity through the device. A plurality of the sections comprise a partition extending across the main axial cavity such that the partitions are axially spaced along the main axial cavity of the device. The device comprises a side cavity for each partition and an aperture coupling each side cavity to the main axial cavity, each aperture being adjacent its respective partition and interfaces between the sections of the device are aligned through the apertures.
The invention relates to platinum and rhenium complexes of formula (I) that may be used as imaging agents. In particular, the invention relates to imaging agents, for example imaging agents for use in the imaging of peroxisomes. Certain embodiments of the invention relate to compounds per se. Other embodiments relate to a process for the preparation of compounds and to the use of compounds as imaging agents. (Formula (I))
There is disclosed a vehicle passenger monitoring system in which an imaging sensor arranged to capture images of a scene including one or more vehicle access point. An image processor is arranged to receive the output of the imaging sensor. The image processor has an object detector for determining the presence of discrete objects in the scene based on variation of one or more visual parameter within the captured images. An object identifier/classifier is arranged to determine an object type for the detected objects from a list of object types that includes both animate and inanimate objects. A scene analyser identifies one or more condition for the imaged scene based on the identified object types. A signal generator generates an output including information derived from said condition and transmits said output to a communication system for communication to one or more individual. The system may be used to generate a passenger information display and/or to monitor and report on adverse conditions such as overcrowding or hazards to a vehicle operator or driver.
B61L 15/00 - Indicateurs de signalisation sur le véhicule ou sur le train
B61L 23/04 - Dispositifs de commande, d'avertissement ou autres dispositifs de sécurité le long de la voie ou entre les véhicules ou les trains pour contrôler l'état mécanique de la voie
B61L 27/00 - Systèmes centraux de commande du trafic ferroviaireCommande côté voieSystèmes de communication spécialement adaptés à cet effet
A real-time method and data processing apparatus for identifying an anomalous state of a system are described. The system includes a sensor outputting time series data items relating to a property of the system. A current data item is received from the sensor. An estimate of a current data density for the time series data items is recursively estimated using the current data item. At least one statistical property of the estimate of the current data density is recursively calculated. It is determined, from the at least one statistical property, whether the current data item indicates an anomalous state of the system. A signal is output if it is determined that the current data item indicates an anomalous state of the system.
A neutron source (200), method of generating neutrons and target stage (206) are described. The neutron source includes a source of deuterons (218), an accelerator (230) and a target stage including an oxygen containing target (254) and a moderator (292). The accelerator is in communication with the source and is operable to accelerate deuterons from the source of deuterons and output a deuteron beam (282) of at least 2 MeV. The target stage is in communication with an output of the accelerator, and the oxygen containing target (286) is positioned to be impacted by the deuteron beam output by the accelerator and generate neutrons which are moderated to generate an output neutron beam (294). The target material can be solid carbon dioxide. This can provide a compact neutron source particularly suited to industrial and commercial applications such as isotope production.
A pervasive display system, including at least one display device for presenting content, is characterized in that the system further includes a content creator being configured to annotate content with contextual presentation goals that specify when, where, and how said content should be presented, a context component being configured to sense and manage context information about humans, objects and/or places as well as about said display devices, and a content distribution and scheduling component being configured to distribute and schedule said content to appropriate display devices of said network on the basis of said annotated contextual presentation goals together with said context information. Furthermore, a method for operating a pervasive display system is disclosed.
An unpowered device for providing an aquatic wildlife ladder for giving passage upstream and downstream for animals and fish. An example comprises an upright or substantially vertically mounted housing containing one or more substantially helical surface(s) over which water may flow, providing a continuous water path and preferably easy means of entrance and exit. As water flows through the device it is adapted to turn a central shaft, so that electrical or other useful power may be generated. The present invention is particularly applicable to low-head installations where existing technologies cannot effectively balance investment, hydro-generation, land requirements and ecosystem protection. A particular advantage in such installations in preferred embodiments, is that the device may take the whole flow through a single channel making it easier for wildlife to sense the correct route.
Computer implemented machine learning methods are described. A co-operative learning method involves a first rule based system and a second rule based system. A rule base is generated from input data and recursion data is used to recursively update the rule base as a result of newly received input data. Rule data defining at least one rule and associated data are sent to the second system which determines whether to update its rule base using the transmitted rule data, and if so the recursion data is used to recursively determine the updated rules for its rule base. A father machine learning method for a rule based system, involves receiving time series data, determining whether the data increases or decreases the spatial density for previously existing rules, and if so then creating a new cluster and associated rule, otherwise a new cluster is not created.
Disclosed is a fluid sampling device comprising a housing arranged to be freely rotatable under the influence of a fluid and comprising an opening for channeling the fluid through the housing such that the fluid contacts a particular portion of a sampling medium corresponding to a relative angular position of the housing.
brevets
