Systems and methods disclosed herein relate to the detection of irregular particles in a blood flow based on a determined relative speed of a particle suspended in a blood flow and/or other properties of a particle suspended in a blood flow including a particle's relative position within a blood vessel and a particles tendency to cluster with other particles suspended in a blood flow. Based on a determined relative speed and/or other relevant factors, the properties of irregular particles may also be measured, including the size, shape, and frequency of irregular particles in a blood flow. Machine learning techniques may be employed to determine patterns for the behavior of irregular particles suspended in a blood flow. These patterns may correspond to particular health risks and conditions.
Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
Disclosed herein include methods and compositions suitable for use in modulation of aversive taste tolerance. In some embodiments, ingestion of sodium and/or aversive substances is reduced. Also disclosed include methods for identifying modulators for aversive taste tolerance.
A61K 31/5513 - 1,4-Benzodiazépines, p. ex. diazépam
A61K 31/192 - Acides carboxyliques, p. ex. acide valproïque ayant des groupes aromatiques, p. ex. sulindac, acides 2-aryl-propioniques, acide éthacrynique
A61P 27/00 - Médicaments pour traiter les troubles des sens
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
4.
SILICATE PLATFORM AS WEAKLY-COORDINATING ANIONS FOR DIVERSE ORGANOMETALLIC TRANSFORMATIONS AND ELECTROCHEMICAL APPLICATIONS
A new class of weakly coordinating anions (WCA) based on silicates is disclosed. Facile tuning of sterics and solubility of the disclosed WCA may be achieved via variation of R groups. The anions support a range of cations employed in chemical reactivity, including ether-free alkali cations, Ag+, Ph3C+, Fc+, [NiI(COD)2]+. In one aspect, [Pd(dppe)(NCMe)Me]+ may be generated by salt metathesis or protonation of a metal-alkyl bond, showcasing the ability of the anions to support applications in coordination chemistry and catalysis. Electrochemical studies on the [Bu4N]+ variant show an exceptionally wide stability window for the MeSiF24− anion of 7.5 V in MeCN. CV experiments demonstrate reversible Mg deposition and stripping.
This disclosure provides HIV immunogens and use thereof for generating an immune response in a subject. Also disclosed is a method of isolating anti-HIV antibodies and use thereof. This disclosure further provides a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject using the disclosed HIV immunogens and/or antibodies.
Techniques for determining stroke risk are provided. In some embodiments, the techniques may involve causing, using one or more light sources disposed on a headset worn by a user, light to be emitted into the head of the user. The techniques may involve obtaining, using one or more light detectors disposed on the headset, information indicative of light reflected from one more structures within the head, wherein a portion of the obtained information spans a time period during which the user was holding their breath. The techniques may involve based on the obtained information, determining one or more cerebral blood metrics. The techniques may involve providing a representation of the one or more cerebral blood metrics as input to a trained machine learning model, and determining a likelihood the user will experience a stroke over a predetermined future time period based on an output of the trained machine learning model.
G16H 40/67 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement à distance
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
Techniques for monitoring cerebral blood metrics such as cerebral blood flow, cerebral blood volume and/or heart rate are provided. In some embodiments, techniques involve a headset with at least one laser configured to emit light into the brain and one or more light detectors such as CMOS sensors that generate information indicative of light reflected from one or more structures within the brain, which can be used to determine the cerebral blood metrics. Each light detector may be positioned within 5 mm of the scalp in some cases.
A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/0255 - Instruments d'enregistrement spécialement adaptés à cet effet
Methods and systems for the electrochemical epoxidation of alkenes to generate an epoxide are described herein. Said methods and systems comprise: contacting an anode comprising an oxygen atom transfer electrocatalyst with an alkene in the presence of an electrolyte comprising water; applying a voltage to the anode and a cathode to generate the epoxide; wherein the oxygen atom transfer electrocatalyst comprises an at least partially oxidized palladium-platinum alloy characterized by the formula FX1: PdyPtzOx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 11/075 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’un seul élément catalytique ou composé catalytique
9.
Liquid accommodating intraocular lens with an asymmetric chamber
An accommodating intraocular lens (IOL) is formed from an anterior or posterior half molded as a chambered, polymer sack with a mouth opening smaller than its largest width that is mated to another half molded as a pliable bowl having a rim larger than the rest of the half. The resulting shell has a seam that is parallel to and does not cross or touch the equator such that the IOL is asymmetric between its front and back. A circular depression around the optical axis can be made in the anterior and/or posterior half such that a surrounding capsular bag seals against the rim of the depression, and an interior of the depression(s) does not touch the capsular bag.
The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
11.
AUXILIARY GYROSCOPE APPROACH FOR BALANCED PERFORMANCE VIA GYRO SELF-CALIBRATION
Methods and devices for bias gyroscopes self-calibration are disclosed. The described teachings can be applied to inertial measurement units implementing one or more auxiliary Coriolis Vibratory Gyroscope (CVG) in conjunction with one or more primary gyroscopes. The auxiliary CVG, capable of mode-switching, enables continuous bias estimation for both its own operation and those of the primary gyroscopes without relying on external aiding sensors. The disclosed methods implement a Kalman filter for bias estimation and can update estimates either at every measurement time step or at mode switching intervals. By combining the good noise performance of primary gyroscopes with the bias stability improvement from the auxiliary CVG, an enhanced overall performance can be achieved.
G01C 19/5776 - Traitement de signal non spécifique à l'un des dispositifs couverts par les groupes
G01C 25/00 - Fabrication, étalonnage, nettoyage ou réparation des instruments ou des dispositifs mentionnés dans les autres groupes de la présente sous-classe
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
An intraocular lens (IOL) has a small, central lens suspended within a pliable housing and, when the housing is filled with liquid, is coaxially aligned with a second small lens embedded in the wall of the housing. The suspension is on a dome- or other-shaped webbing attached to an inner circumference of the wall. When filled with liquid, forces squeezing or pulling the equator of the housing, as with ciliary muscles in the eye, adjust a distance between the lenses in order to adjust focus. Optional haptics may project from points on or above and below the equator. A recess in the posterior hemisphere of the housing can keep cell growth away from an optical axis of the lens system. A third small lens can be embedded in an opposite wall of the housing and coaxially aligned with the other lenses to form a three-lens, ultra-zoom system.
A method for etching a surface including obtaining a substrate comprising a material; reacting a surface of a substrate with a reactant, comprising a gas or a plasma, to form a reactive layer on the substrate, the reactive layer comprising a chemical compound including the reactant and the material; and wet etching or dissolving the reactive layer with a liquid wet etchant of solvent that selectively etches or dissolves the reactive layer but not the substrate.
H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
H01L 21/677 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants pour le transport, p. ex. entre différents postes de travail
15.
CLEAVE AND RESCUE GAMETE KILLERS FOR GENE DRIVE IN PLANTS
Described herein are embodiments relating to manipulation of the composition, numbers and sex ratio in plant populations through DNA sequence modifications.
Lithium niobate (LiNbO3, LN) is a ferroelectric crystal of interest for integrated photonics owing to its large second-order optical nonlinearity and the ability to impart periodic poling via an external electric field. However, on-chip device performance based on thin-film lithium niobate (TFLN) is presently limited by propagation losses arising from surface roughness on the nano- and microscale. Atomic layer etching (ALE) can smooth these features and thereby increase photonic performance. In one embodiment disclosed herein, an isotropic ALE process for x-cut MgO-doped LN uses sequential exposures of H2 and SF6/Ar plasmas. We observed an etch rate of 1.59±0.02 nm/cycle with a synergy of 96.9%. ALE can be achieved with SF6/O2 or Cl2/BCl3 plasma exposures in place of the SF6/Ar plasma step with synergies of 99.5% and 91.5% respectively. The process decreased the sidewall surface roughness of TFLN waveguides etched by physical Ar+ milling by 30% without additional wet processing.
H10N 30/082 - Mise en forme ou usinage de corps piézo-électriques ou électrostrictifs par gravure, p. ex. par lithographie
H01L 21/67 - Appareils spécialement adaptés pour la manipulation des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide pendant leur fabrication ou leur traitementAppareils spécialement adaptés pour la manipulation des plaquettes pendant la fabrication ou le traitement des dispositifs à semi-conducteurs ou des dispositifs électriques à l'état solide ou de leurs composants
17.
Systems and Methods for Communicating by Modulating Data on Zeros in the Presence of Channel Impairments
Communication systems and methods in accordance with various embodiments of the invention utilize modulation on zeros. Carrier frequency offsets (CFO) can result in an unknown rotation of all zeros of a received signal's z-transform. Therefore, a binary MOCZ scheme (BMOCZ) can be utilized in which the modulated binary data is encoded using a cycling register code (e.g. CPC or ACPC), enabling receivers to determine cyclic shifts in the BMOCZ symbol remitting from a CFO. Receivers in accordance with several embodiments of the invention include decoders capable of decoding information bits from received discrete-time baseband signals by: estimating a timing offset for the received signal; determining a plurality of zeros of a z-transform of the received symbol; identifying zeros from the plurality of zeros that encode received bits by correcting fractional rotations resulting from the CFO; and decoding information bits based upon the received bits using a cycling register code.
Bistable devices are constructed using a polynucleotide platform for the sensing of molecular events such as binding or conformational changes of target molecules. Uses include measurement of target concentration, measuring the effect of environmental condition (such as heat, light, or pH) on the target, or screening a library for molecules that bind the target or modulate its biological function. Devices comprise three regions: a top lid, bottom lid, and flexible linker or hinge between them. A device has an open configuration in which the top and bottom lid are separated, and a closed configuration they are bound close together. Binding domains or variations of the target molecule are fixed to a device so that when the molecular event occurs, the device switches from open to closed, or vice versa, which generates a signal. Devices carry DNA tags to enable separation of open and closed devices, as well as barcoding for multiplexed detection.
The present invention relates to broadly neutralizing anti-HIV-1 antibodies and isolated antigens. Also disclosed are related methods and compositions.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
A61K 39/42 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire viraux
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
In many embodiments of the invention, a space-based data center includes orbital server modules configured to be deployed in space, each module including a communication subsystem for module-to-module communications to form a data center, tiles arranged in a planar array, where each tile has a layered structure including solar cells forming a layer across a first surface, thermal radiator panels forming a layer across a second surface, electronic components distributed laterally in a layer between the layer of solar cells and the layer of thermal radiator panels, where each electronic component receives power locally from solar cells and rejects heat to the thermal radiator panel beneath it, where a first subset of tiles are compute tiles in which the electronic components include one or more computing processors and memory, and where a second subset of tiles are support tiles in which the electronics components include network switches and energy storage.
A circuit comprising a first Fourier Transform block operable to perform a Fourier Transform and having a first input configured for receiving an I signal and a second input configured for receiving a Q signal; a first plurality of n of outputs for I channels and Q channels each comprising a different frequency bin output from the Fourier Transform; I and Q summing blocks comprising a set of connector lines connecting an ith one of I channels with an ith one of the Q channels; an inverse Fourier Transform block connected to the summing blocks and operable to perform an inverse Fourier Transform; a correlator for correlating the outputs of the inverse Fourier Transform; a Fourier Transform block for Fourier Transforming the correlator output; a comparator for comparing the correlation term to zero; and an error correction circuit for tuning the magnitude and phase of the I and Q channels using the comparator output as feedback.
Disclosed herein are analogs and derivatives of aleutianamine and methods of making the same. Also disclosed herein are methods of treating pancreatic cancer comprising administration of aleutianamine or its analogs.
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
Disclosed herein include methods, compositions, and kits suitable for use in tuned dosage-invariant expression of a payload protein. Compositions (e.g., nucleic acid compositions, one or more cells) provided herein can comprise a first promoter sequence operably linked to a first polynucleotide comprising one or more miRNA cassettes, and a second promoter sequence operably linked to a second polynucleotide comprising a payload gene. In some embodiments, the first promoter sequence is capable of inducing transcription of the first polynucleotide to generate a first transcript, and the first transcript is capable of being processed to generate said miRNA. The payload gene can comprise a miRNA target region comprising one or more miRNA target sequences.
Described herein are compositions having an eight-membered monocyclic unsaturated hydrocarbon, methods and system to separate the eight-membered monocyclic unsaturated hydrocarbon at from a hydrocarbon mixture including additional nonlinear unsaturated C8H2m hydrocarbons with 4≤m≤8, by contacting the hydrocarbon mixture with a 10-ring pore molecular sieve having a sieving channel with a 10-ring sieving aperture with a minimum crystallographic free diameter greater than 3 Å and a ratio of the maximum crystallographic free diameter to the minimum crystallographic free diameter between 1 and 2, the molecular sieve having a T1/T2 ratio ≥20:1 wherein T1 is an element independently selected from Si and Ge, and T2 is an element independently selected from Al, B and Ga, the 10-ring pore molecular sieve further having a counterion selected from NH4+, Li+, Na+, K+ and Ca++.
C07C 7/13 - Purification, séparation ou stabilisation d'hydrocarburesEmploi d'additifs par adsorption, c.-à-d. purification ou séparation d'hydrocarbures à l'aide de solides, p. ex. à l'aide d'échangeurs d'ions par la technique du tamis moléculaire
C07C 13/263 - Hydrocarbures monocycliques ou leurs dérivés hydrocarbonés acycliques à cycle octogonal à cycle du cyclo-octène ou du cyclo-octadiène
C08G 61/08 - Composés macromoléculaires contenant uniquement des atomes de carbone dans la chaîne principale de la molécule, p. ex. polyxylylènes uniquement des atomes de carbone aliphatiques préparés par ouverture du cycle des composés carbocycliques des composés carbocycliques contenant une ou plusieurs doubles liaisons carbone-carbone dans le cycle
Hyper-Heisenberg scaling quantum imaging techniques that pass an idler photon of each entangled photon pair three times through an idler objective pair and pass a signal photon of each entangled photon pair at least once through a signal objective pair and use measurements of coincidence detection to yield a coincidence image with spatial resolution of about four times that of classical imaging.
The present invention relates to methods of treating breast cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound provided herein. In some embodiments the subject can be receiving chemotherapy with a conventional chemotherapy drug and/or a therapeutic monoclonal antibody or drug conjugate thereof.
A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
A61K 31/7072 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées ayant des groupes oxo liés directement au cycle pyrimidine, p. ex. cytidine, acide cytidylique ayant deux groupes oxo liés directement au cycle pyrimidine, p. ex. uridine, acide uridylique, thymidine, zidovudine
C07H 1/00 - Procédés de préparation des dérivés du sucre
An on-chip pulse synthesizer including an integrated photonic chip that temporally and spectrally shapes pulses of light using primarily quadratic optical nonlinearities. Through this synthesis, the light pulses undergo temporal shortening or reshaping, spectral broadening, wavelength conversion, or a combination thereof. A key aspect of this synthesis is the mode engineering of the waveguides, which includes converting the pump source mode to the relevant mode in the nonlinear optical region and tailoring the waveguide geometry and material stack to enable dispersion-engineering as well as engineering of the phase matching for various nonlinear processes.
G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets
28.
METHOD FOR TRANSFERRING A PRESSURE WAVE FROM PERIPHERAL SITE TO CENTRAL SITE
The disclosure relates to techniques for transferring a pulse pressure waveform signal of a peripheral vascular site to a central vascular site. In some implementations, a method includes: obtaining a time-domain representation of a first pulse pressure waveform signal of a brachial artery of a subject; converting the time-domain representation of the first pulse pressure waveform signal to a frequency-domain representation of the first pulse pressure waveform signal; selecting a first plurality of frequency components of the frequency-domain representation of the first pulse pressure waveform signal; predicting, using a non-linear mapping, based on the first plurality of frequency components, a second plurality of frequency components of a frequency-domain representation of a second pulse pressure waveform signal of an ascending aorta or left ventricle of the subject; and converting the frequency-domain representation of the second pulse pressure waveform signal to a time-domain representation of the second pulse pressure waveform signal.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
A61B 5/025 - Mesure du pouls ou des pulsations cardiaques utilisant des capteurs engendrant des signaux électriques à l'intérieur de dispositifs d'occlusion, p. ex. en réponse à des bruits de Korotkoff
29.
OPTICAL FIBER-BASED TSUNAMI WARNING SYSTEM USING SUBMARINE TELECOMMUNICATION CABLES
The invention describes a tsunami warning system utilizing properties of light in optical fibers within submarine telecommunication cables. Enhanced by microwave frequency modulation and High-Loss Loop Back (HLLB) techniques, this system measures photoelastic changes for more stable, long-period tsunami wave detection.
G08B 21/10 - Alarmes pour assurer la sécurité des personnes réagissant aux événements désastreux, p. ex. les tornades ou les tremblements de terre
G01L 11/02 - Mesure de la pression permanente, ou quasi permanente d'un fluide ou d'un matériau solide fluent par des moyens non prévus dans les groupes ou par des moyens optiques
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
G06F 17/11 - Opérations mathématiques complexes pour la résolution d'équations
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 25/00 - TIC spécialement adaptées à l’hybridationTIC spécialement adaptées à l’expression de gènes ou de protéines
G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
31.
MOLECULAR RECORDING METHODS AND SYSTEMS TO CAPTURE LINEAGE RELATIONSHIPS IN DIFFERENTIATING STEM CELLS
Disclosed herein include methods, compositions, and kits suitable for use in capturing lineage relationships in dividing cell populations. Disclosed herein include compact phylogenetic recording systems for high resolution lineage reconstruction over long time scales. In some embodiments, the system comprises one or more hypercascade array(s) each comprising p hypercascade units, n layer guide RNAs, and an editor. In some embodiments, the system comprises one or more target array(s) comprising n editable target sites, n guide RNAs gRNAs, and a base editor capable of adenine (A)-to-guanine (G) base editing.
Imaging methods and apparatus for localizing biopsy needles coupled to an ultrasonic transmitter and/or monitoring ablation of an ablation probe connected to a microwave source, which include an arbitrary waveform generator for generating a chirp signal that excites the ultrasonic transmitter to generate an ultrasonic signal or modulates the microwave signal.
Systems and methods for a wearable system that monitors various biomarkers with a 3D-printed wearable electronic skin. Specifically, the wearable system is a 3D-printed epidermal wearable microfluidic electronic skin that may be composed of a combination of multidimensional nanomaterials, polymers, and hydrogels. The epidermal wearable microfluidic electronic skin may be integrated with sensors, electrodes, microfluidics, and a processor to collect and analyze molecular biomarkers of biofluid samples on the user's skin, while simultaneously analyzing the user's physiological biomarkers to conduct a health status assessment or gather health monitoring/surveillance metric.
G06F 3/01 - Dispositions d'entrée ou dispositions d'entrée et de sortie combinées pour l'interaction entre l'utilisateur et le calculateur
B29C 48/00 - Moulage par extrusion, c.-à-d. en exprimant la matière à mouler dans une matrice ou une filière qui lui donne la forme désiréeAppareils à cet effet
B33Y 80/00 - Produits obtenus par fabrication additive
National Taiwan Normal University (Taïwan, Province de Chine)
Inventeur(s)
Yeh, Nai-Chang
Hao, Duxing
Lan, Yann-Wen
Lu, Ting-Hua
Abrégé
A field effect transistor including a substrate; a monolayer of a single crystal semiconducting transition metal dichalcogenide (TMD) on the substrate; a source contact and a drain contact to the strained monolayer; and a gate contact on the substrate; wherein the a gate voltage applied to the gate contact with respect to the source contact modulates a ferroelectric response of the monolayer when strained and a current through the monolayer between the source contact and the drain contact; and wherein the substrate is rigid and the monolayer experiences asymmetric lattice expansion when strained against the rigid substrate in response to an external magnetic field or the substrate is a strain engineered substrate inducing asymmetric lattice expansion of the monolayer.
H01L 31/0352 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails caractérisés par leurs corps semi-conducteurs caractérisés par leur forme ou par les formes, les dimensions relatives ou la disposition des régions semi-conductrices
G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
H01L 31/032 - Matériaux inorganiques comprenant, à part les matériaux de dopage ou autres impuretés, uniquement des composés non couverts par les groupes
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for neutralizing a range of HIV strains. Combinations of broadly neutralizing antibodies can also improve potency over a single antibody composition.
Disclosed herein is a composition for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a kit for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples. Also disclosed herein, is a method for nuclease treatment of hybridized probes in experiments to profile and analyze biological samples.
In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
This present disclosure provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample. Also provided herein are biosensor arrays, systems and methods for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The present disclosure also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
C12Q 1/6837 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide utilisant des réseaux de sondes ou des puces à sondes
C40B 30/04 - Procédés de criblage des bibliothèques en mesurant l'aptitude spécifique à se lier à une molécule cible, p. ex. liaison anticorps-antigène, liaison récepteur-ligand
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
H01L 27/144 - Dispositifs commandés par rayonnement
39.
ELECTROCHEMICAL INHIBITION OF REDOX ACTIVE BACTERIA AND RELATED DEVICES, METHODS AND SYSTEMS
Provided herein are methods and systems and related devices and compositions for electrochemical control of viability of redox active bacteria. The electrochemical control is performed by applying to a working electrode contacting a medium known or suspected to comprise the redox active bacteria, a reducing potential which is lower of the midpoint potential of a redox active compound produced by the redox active bacteria.
A61L 2/03 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques du courant électrique, p. ex. électrolyse
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
The present invention, among other things, provides technologies for detecting and/or quantifying nucleic acids in cells, tissues, organs or organisms. In some embodiments, through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and/or DNA loci.
A system and method for joint dynamic interest request forwarding and dynamic cache placement and eviction and provided within the context of the Named Data Networking (NDN) architecture. The system and method employ a virtual control plane that operates on the user demand rate for data objects in the network, and an actual plane that handles Interest Packets and Data Packets. Distributed algorithms within the virtual plane achieve network load balancing through dynamic forwarding and caching, thereby maximizing the user demand rate that the NDN network can satisfy. A method of congestion control is also provided to achieve optimal network fairness using the VIP framework.
A method to perform vision based navigation on a moving vehicle. An image processor receives reference images with associated depth information as base frames or search frames. 2D features are detected in base frames and tracked in subsequent search frames. A new base frame is triggered when a number of features or a spatial distribution fall under thresholds. A depth processor reconstructs the depth and 3D position of each of the 2D features. A track manager manages a feature list database mapping the 2D coordinates of each tracked 2D feature with the 3D coordinate of that feature. A state manager constructs a filter state vector with 15 error states propagated at an IMU rate and 6 additional error states corresponding to clones of pose states. A visual updater utilizes the tracked 2D feature coordinates to update the filter state vector. A filter forms residuals and corrects inertial error drift.
G01C 21/28 - NavigationInstruments de navigation non prévus dans les groupes spécialement adaptés pour la navigation dans un réseau routier avec corrélation de données de plusieurs instruments de navigation
G06T 7/246 - Analyse du mouvement utilisant des procédés basés sur les caractéristiques, p. ex. le suivi des coins ou des segments
G06T 7/593 - Récupération de la profondeur ou de la forme à partir de plusieurs images à partir d’images stéréo
G06T 7/73 - Détermination de la position ou de l'orientation des objets ou des caméras utilisant des procédés basés sur les caractéristiques
43.
INVERTING EARTHQUAKE FOCAL MECHANISMS WITH DISTRIBUTED ACOUSTIC SENSING
The present invention infers the first-motion polarities using the relative polarities measured from cross-correlations. We demonstrate two real-world applications on two DAS arrays in the manuscript to illustrate the effectiveness of our method and improvements to the focal mechanism inversion.
G01V 1/22 - Transmission des signaux sismiques aux appareils d'enregistrement ou de traitement
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
G01D 5/353 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens optiques, c.-à-d. utilisant de la lumière infrarouge, visible ou ultraviolette avec atténuation ou obturation complète ou partielle des rayons lumineux les rayons lumineux étant détectés par des cellules photo-électriques en modifiant les caractéristiques de transmission d'une fibre optique
G01V 1/01 - Mesure ou prévision des tremblements de terre
Disclosed herein include methods, compositions, and kits suitable for use in the measurement of the states of living cells across time and for use in the delivery of polyribonucleotides and circuits. There are provided, in some embodiments, RNA exporter proteins comprising an RNA-binding domain, a membrane-binding domain, and an interaction domain capable of nucleating self-assembly. Disclosed herein include polynucleotides encoding reporter RNA molecule(s) or cargo RNA molecule(s). In some embodiments, a plurality of RNA exporter proteins are capable of self-assembling into lipid-enveloped nanoparticles (LNs) secreted from a cell in which the RNA exporter proteins are expressed, thereby generating a population of LNs comprising exported reporter RNA molecule(s) or a fusogen and exported cargo RNA molecule(s). Disclosed herein include export modulator proteins capable of, e.g., enhancing or suppressing LN export.
Disclosed herein are methods that can be used to improve, treat and/or inhibit neurodevelopmental disorders in subjects in need, for example subjects suffering from Parkinson's disease. Some embodiments include administering an effective amount of fecal microbiota to the subject in need thereof, wherein the fecal microbiota is derived from healthy donors who are younger in age as compared to the subjects suffering from Parkinson's disease. Upon treatment, one or more symptoms of neurodevelopmental disorders can be improved in the subject.
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
Systems and methods for transducing and storing qubit signals are provided. The system includes a voltage source, a substrate, and a membrane suspended over the substrate. A phononic crystal oscillator is disposed in a first region of the membrane. The phononic crystal oscillator includes a capacitor having a moving electrode including an array of multiple phononic crystal unit cells. The moving electrode is connected to the voltage source. A superconducting circuit disposed in a second region of the membrane. A plurality of phonon shields and an optical resonator may also be disposed on the membrane.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
H04B 10/516 - Détails du codage ou de la modulation
48.
MULTIVALENT CARRIERS AND RELATED VACCINE COMPOSITIONS
Disclosed herein include multivalent carriers comprising a plurality of heterologous coronavirus proteins antigens derived from different coronaviruses. The multivalent carriers herein described can elicit heterologous binding and neutralization properties against coronaviruses that differ from the coronaviruses from which the coronavirus antigens are derived to produce the multivalent carriers. Also provided herein include vaccine compositions comprising the multivalent carriers and related methods using the vaccine compositions in various therapeutic and prophylactic applications.
The present application relates to hybridization chain reaction (HCR). The sensitivity and multiplexing of hybridization chain reaction (HCR) signal amplification are combined with target detection using barcode probes or barcode fusion probes, wherein a barcode probe or barcode fusion probe comprises a primary probe (comprising a target-binding domain) bound to a secondary probe (comprising a primary-probe-binding-domain and a barcode oligonucleotide comprising an HCR initiator or an HCR fractional initiator).
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
A method of correcting for crosstalk in thermo-optics phase shifters (TOPS) integrated on a substrate, includes, in part, determining a first value representative of an amount of electrical power applied to a heater associated with a first TOPS causing a known phase shift in an optical signal passing through the first TOPS' associated waveguide; determining a second value representative of a time constant of the first TOPS; determining a third value representative of an amount of electrical power applied to a heater associated with a second TOPS causing a known phase shift in an optical signal passing through the waveguide associated with the first TOPS; determining a multitude of thermal couplings between a multitude of heaters, waveguides and positions in the substrate using one or more of the first, second and third values; and making a correction associated with the crosstalk in accordance with the thermal couplings.
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
A computer-implemented method useful for performing seismic tomography, including obtaining seismic data comprising distributed acoustic sensing (DAS) data, comprising at least one of P-wave or S-wave travel times from a plurality of seismic events to a plurality of recording stations coupled to a network of optical fibers in a geological structure; and generating tomography data from the DAS data, wherein tomography data is useful for characterizing the geological structure. We employ distributed acoustic sensing data recorded along a 100-km fiber-optic cable traversing the caldera to image its subsurface structure. Our images highlight a definite separation between the shallow hydrothermal system and the large magma chamber located at ˜12 km depth. The combination of the geological evidence with our results shows how fluids exsolved through second boiling provide the source of the observed uplift and seismicity. Thus Fiber-seismic tomography reveals that the unrest in the Long Valley Caldera is likely driven by fluid from second boiling, not new magma intrusion.
Systems and methods for activating mechanochemical reactions remotely using biocompatible ultrasound in the presence of gas-filled structures are described. The collapse of gas-filled structures is achieved using biocompatible ultrasound. In turn, collapse of the gas-filled structures can mechanochemically activate mechanophore-functionalized polymers in solution. Mechanochemical activation of mechanophore-functionalized polymers under physiological conditions can trigger the release and/or delivery of a variety of cargos with the spatial and temporal precision and deep tissue penetration afforded by focused ultrasound.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
54.
VOLUMETRIC SILICON META-OPTICS FOR COMPACT AND LOW-POWER TERAHERTZ SPECTROMETERS
A device including a stack of silicon meta-optical layers forming a meta-material comprising an input surface for receiving terahertz electromagnetic radiation, an output surface for outputting a plurality of beams of the electromagnetic radiation; and a spatially varying permittivity varying with sub-wavelength precision across a volume of the stack, wherein the spatially varying permittivity is configured to focus different spectral bands of the electromagnetic radiation into different spatially separated electromagnetic modes.
G01J 3/02 - SpectrométrieSpectrophotométrieMonochromateursMesure de la couleur Parties constitutives
B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
B82Y 40/00 - Fabrication ou traitement des nanostructures
G01J 3/26 - Production du spectreMonochromateurs en utilisant une réflexion multiple, p. ex. interféromètre de Fabry-Perot, filtre à interférences variables
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
55.
HIGHLY ACTIVE AGONISTIC CD4 BINDING SITE ANTI-HIV ANTIBODIES (HAADS) COMPRISING MODIFIED CDRH2 REGIONS THAT IMPROVE CONTACT WITH GP120
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.
A device implementing a nonlinear activation function including a material having nonlinear susceptibility phase-matching a coherent nonlinear interaction involving a signal comprising a signal wavelength and a bias comprising a bias wavelength, so that (1) a first phase difference between the signal and the bias induces the interaction comprising second harmonic generation (generating a second harmonic of the bias wavelength) or sum frequency generation (generating a sum frequency of the bias and the signal, and (2) a second phase difference between the signal and the bias induces the interaction comprising parametric amplification amplifying the bias and attenuating the signal. A positive input to the nonlinear activation function is represented by the signal having an input energy and the first phase difference. A negative input is represented by second phase difference. The output is an output energy of the signal as function of the input energy.
G06N 3/067 - Réalisation physique, c.-à-d. mise en œuvre matérielle de réseaux neuronaux, de neurones ou de parties de neurone utilisant des moyens optiques
A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. The second region extends through the solid and a subset of said second region comprise surface metal unit cells that are adjacent to at least one unit cell from the first region. The ratio of the number of said surface metal unit cells to the total number of unit cells in the second region being at least 20 percent.
C04B 35/45 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxyde de cuivre ou de ses solutions solides avec d'autres oxydes
C04B 35/626 - Préparation ou traitement des poudres individuellement ou par fournées
Systems and devices for dynamic damping of vibrations are described. Traditional methods of vibration damping often involve trade-offs between stiffness and damping, potentially compromising structural integrity for increased damping. The performance of these damping techniques can also be influenced by the specific profile of the vibrational excitation, presenting challenges in ensuring consistent and reliable damping across different operating conditions. A tunable friction-damping device formed from concentric layers can overcome many of these limitations and presents methods for dynamic damping of vibrations as an alternative solution.
F16F 15/121 - Suppression des vibrations dans les systèmes rotatifs par utilisation d'organes mobiles avec le système lui-même utilisant des organes élastiques ou des organes amortisseurs de friction, p. ex. entre un arbre en rotation et une masse giratoire montée dessus utilisant des ressorts comme organes élastiques, p. ex. des ressorts métalliques
F16F 1/10 - Ressorts spiraux dont les enroulements constituent sensiblement une surface plane
A sensor including a resonator comprising a nonlinear material comprising a nonlinear susceptibility configured to convert a pump electromagnetic wave (EM) wave to a signal EM wave and an idler EM wave, wherein at least one of the pump EM wave, the signal EM wave and/or the idler EM wave is fed back through the nonlinear material to form one or more resonant EM waves. An actuator coupled to the resonator or a pump path to the resonator, controls at least one of a pump power of the pump EM wave, a detuning of the frequency modes of the resonator relative to one or more frequencies of the resonant EM waves, or a phase matching of the nonlinear material. An output of the resonator outputs one or more output EM waves comprising information about a sample coupled to the resonator.
Cross-ray ultrasound tomography systems and methods that employ an ultrasonic emitter and an ultrasonic detector array where the ultrasonic emitter is outside a plane at elements of the ultrasonic detector array, and ultrasonic wave(s) are emitted by the ultrasonic emitter at an angle to the plane at the elements of the ultrasonic detector array.
Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.
An apparatus including a source of electromagnetic radiation comprising one or more first frequencies; a source of an input signal comprising an alternating (AC) electric field comprising one or more second frequencies; a control circuit synchronizing application of the electromagnetic radiation and the AC electric field applied to a sample, so that an output signal comprising a modulation of the AC electric field is outputted from the sample in response to (1) the one or more second frequencies tuned to drive hopping of ions between ion sites in the sample, and the one or more first frequencies tuned to drive excitations in the sample that interact with the ions. The apparatus further includes a detection system measuring and/or detecting a change in the output signal in response to the electromagnetic radiation; and a computer determining at least one of a conductivity or impedance of the sample from the output signal and as a function of the first frequencies and the second frequencies.
G01N 27/04 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'impédance en recherchant la résistance
63.
LIQUID FLOW INDUCED POWER GENERATION USING NANOSCALE METAL LAYERS
Energy harvesting devices and methods for converting the mechanical energy of a flowing ionic solution, such as rainwater or seawater, into electric energy are provided. The energy harvesting devices include an electric current generating device that includes a metal layer and an amphoteric metal oxide film disposed over a surface of the metal layer. By moving an electric double layer across the surface of the amphoteric metal oxide film, an electric current is generated in the metal layer.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
An interactive modular device for instructing and assisting users on sample handling processes using features to guide a user through the processes in real time. The modules of the device include a processing module (e.g., pooling module), a sample-container module (e.g., tube module), a container-closure module (e.g., cap module), a sample-transfer module (e.g., pipette module), a scanning module (e.g., single barcode module), a multi-scanning module (e.g., multi-barcode module), a waste container module, and a display module. The features include mechanisms to determine presence and absence of items used for sample handling and visual, audible, and tactile indicators in real time.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
66.
HIGH-RESOLUTION WHOLE GENOME IMAGING BY NUCLEIC ACID LOCUS AND BLOCK CODING
The present disclosure provides methods for analyzing genomic structures by diffraction limited locus imaging and nucleic acid block coding. The methods allow efficient and scalable imaging, which can be applied to multiplexed RNA/DNA fluorescence in situ hybridization (FISH).
Certain aspects pertain to intra-image motion correction methods and systems configured to divide an image domain into subdomains and estimate motion of each subdomain along one or more axes and determine a motion corrected image based on the motions.
Aspects of the invention include a method of producing a cement material comprising step of: first reacting a calcium-bearing starting material with a first acid to produce an aqueous first calcium salt; second reacting the aqueous first calcium salt with a second acid to produce a solid second calcium salt; wherein the second acid is different from the first acid and the second calcium salt is different from the first calcium salt; and thermally treating the second calcium salt to produce a first cement material. Preferably, but not necessarily, during the second reacting step, reaction between the first calcium salt and the second acid regenerates the first acid.
C04B 40/00 - Procédés, en général, pour influencer ou modifier les propriétés des compositions pour mortiers, béton ou pierre artificielle, p. ex. leur aptitude à prendre ou à durcir
C07C 1/32 - Préparation d'hydrocarbures à partir d'un ou plusieurs composés, aucun d'eux n'étant un hydrocarbure à partir de composés renfermant des hétéro-atomes autres que l'oxygène ou les halogènes, ou en addition à ceux-ci
69.
SPLIT AND POOL IDENTIFICATION OF RBP TARGETS (SPIDR)
The Trustees of Columbia University in the City of New York (USA)
Inventeur(s)
Wolin, Erica
Guo, James
Guttman, Mitchell
Jovanovic, Marko
Abrégé
Aspects of the present disclosure generally relate to methods and compositions for detecting an association between a RNA binding protein and a RNA. Some aspects of the present disclosure relate to methods of generating an antibody-bead conjugate pool. Some aspects of the present disclosure relate to kits and compositions for performing the methods disclosed herein.
Systems and methods for miniature spatial heterodyne spectrometer (SHS) systems are described. Methods for optimizing the miniature SHS systems can reduce the sizes and format while achieving high sensitivity and detection quality. The miniature SHS systems can be deployed for handheld use in real-world or remote activities outside of research or diagnostic facilities.
A device including a continuous (CW) wave source of pairs of entangled photons, each pair comprising a first photon entangled with a second photon; a pair of channels comprising a first channel terminated by a first detector configured to detect the first photon and a second channel terminated by a second detector configured to detect a output photon emitted by an excited state of matter excited by the second photon in the second channel; a splitter for splitting the pairs of entangled photons into the channels, so that the first photon comprising a reference photon is transmitted to the first channel and the second photon is transmitted to the second channel; and a timing circuit coupled to the detectors operable to measure a time delay between arrival times measured at the detectors of the output photon and the first photon entangled with the second photon used to generate the output photon (e.g., fluorescence photon).
Disclosed herein include circuits, compositions, nucleic acids, populations, systems, and methods enabling cells to sense, control, and/or respond to their own population size. In some embodiments, an orthogonal communication channel allows specific communication between engineered cells. Also described herein, in some embodiments, is an evolutionarily robust ‘paradoxical’ regulatory circuit architecture in which orthogonal signals both stimulate and inhibit net cell growth at different signal concentrations. In some embodiments, engineered cells autonomously reach designed densities and/or activate therapeutic or safety programs at specific density thresholds. Methods of treatment are also provided in some embodiments.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C07K 14/415 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de végétaux
C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
C12N 9/86 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5) agissant sur les liaisons amides des amides cycliques, p. ex. pénicillinase
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
73.
LEAK-DETECTION SYSTEM AND METHODS FOR LEAK DETECTION
A leak-detection system comprises networked imaging packages including an infrared camera based on microbolometer arrays, one or more filters, and a processor. The processor uses one or more novel processing methods for identifying gas leakages in a monitored facility. In some embodiments, the imaging packages are installed at various locations in the monitored facility. In some other embodiments, the leak-detection system is embodied as a mobile platform, wherein the networked imaging packages are coupled to drones that fly throughout the monitored facility to monitor for gas leakages. The flight path of the cameras may be pre-programmed and may further be alterable in real time. The novel processing technique(s) employed by the leak-detection system disclosed herein involve the use of multiple unique filters that facilitate enhancing the signal-to-noise ratio of captured images; that is, enhancing the contrast of a monitored gas against other objects. The novel processing techniques include one or more of the following: (i) two-image subtraction; (ii) time-resolved imaging; and (iii) multi-filter detection. Additionally, in some embodiments, the imaging packages include a visible (light) camera in addition to an IR camera.
G01M 3/38 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation de la lumière
G06V 10/88 - Reconnaissance d’images ou de vidéos utilisant des moyens optiques, p. ex. filtres de référence, masques holographiques, filtres de domaine de fréquence ou filtres de domaine spatial
74.
SYSTEMS AND METHODS FOR POWERING AUTONOMOUS SWEAT SENSOR
Systems and methods for a self-powered wireless wearable sensor system include a freestanding triboelectric nanogenerator (FTENG), used as a power source for a wearable sensor. The FTENG includes stator panels and corresponding slider panels with a grating pattern. Movement, such as cardiovascular exercise causes the slider panel(s) to slide across the stator panel(s) inducing a charge and powering a wearable device sufficiently to support data transmission and continuous monitoring. An integrated self-powered wireless wearable sensor system includes a microfluidic sweat sensor patch which may be connected to lower-power wireless sensor circuitry for regulating power efficiently and is powered by the FTENG.
Disclosed herein include methods, compositions, and kits enabling expression of multiple payload proteins from a single mRNA configured to achieve a predetermined stoichiometry of first unit payload protein(s) and second unit payload protein(s) in a cell or cell-like environment. There are provided, in some embodiments, nucleic acid compositions comprising a polynucleotide comprising a first nucleic acid unit (encoding one or more first unit payload protein(s)) and a second nucleic acid unit (encoding one or more second unit payload protein(s)). The first nucleic acid unit and the second nucleic acid unit can each comprise an engineered translation initiation site (eTIS) comprising a three-nucleotide tunable element immediately upstream of a start codon. In some embodiments, the nucleic acid composition comprises at least one modified nucleotide and/or at least one nucleotide analogue or nucleotide derivative. In some embodiments, the polynucleotide comprises a disclosed eTIS combination.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
76.
METHODS AND SYSTEMS FOR BOND-SELECTIVE FLUORESCENCE-DETECTED INFRARED-EXCITED IMAGING
Disclosed herein include methods and related systems of bond-selective fluorescence-detected infrared-excited (BonFIRE) spectroscopy. BonFIRE employs two-photon excitation in the mid-IR and near-IR to upconvert vibrational excitations to electronic states for fluorescence detection, thus encoding vibrational information into fluorescence. The method comprises providing a sample comprising a dye molecule having an UV-vis absorption maximum; generating an IR laser and a NIR laser, wherein the IR laser and the NIR laser are coherent; aligning the IR laser and the NIR laser in a counter-propagating configuration on the sample; irradiating the dye molecule with the IR laser and the NIR laser; and detecting a fluorescence from the dye molecule which can be used to extract a bond-selective IR absorption maximum of the dye molecule or form an image of the sample from the fluorescence with single-molecule sensitivity. The WF-BonFIRE technique significantly increases the imaging speed for single-molecule samples and for biological samples.
An auto-powered biosensor capable detecting a target molecule, and a method of powering the same, wherein the biosensor is fabricated with a microfluidics layer, a multimodal sensing layer comprising a biofuel cell and an electrode, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang
A61B 5/1486 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang en utilisant des procédés chimiques ou électrochimiques, p. ex. par des moyens polarographiques en utilisant des électrodes enzymatiques, p. ex. avec oxydase immobilisée
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
H01M 8/16 - Éléments à combustible biochimique, c.-à-d. éléments dans lesquels des micro-organismes agissent comme catalyseurs
78.
DEEP NEURAL NETWORKS FOR OUTCOME-ORIENTED PREDICTIONS
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
79.
ANGULAR PTYCHOGRAPHIC IMAGING WITH CLOSED-FORM RECONSTRUCTION
A device including a chip including a photonic integrated circuit comprising an external cavity for a source of electromagnetic radiation; the source of electromagnetic radiation attached to a top surface of the chip, the source comprising a semiconductor active region comprising, or coupled to, an output for the electromagnetic radiation, wherein the output is oriented to emit the electromagnetic radiation into the top surface in an emission direction that is inclined with respect to a plane of propagation of the electromagnetic radiation in the external cavity; and a coupler coupling the active region to the external cavity via the top surface to integrate the external cavity with the active region. The coupler partially couples the electromagnetic radiation outputted from the active region to the external cavity, and feedback from the external cavity to the active region.
H01S 5/183 - Lasers à émission de surface [lasers SE], p. ex. comportant à la fois des cavités horizontales et verticales comportant uniquement des cavités verticales, p. ex. lasers à émission de surface à cavité verticale [VCSEL]
H01S 5/04 - Procédés ou appareils pour l'excitation, p. ex. pompage
H01S 5/20 - Structure ou forme du corps semi-conducteur pour guider l'onde optique
81.
DIRECT CURRENT- 40 GIGAHERTZ COAX-BASED CRYOGENIC VARIABLE TEMPERATURE LOAD (VTL) WITH EXCEPTIONAL TEMPORAL RESPONSE AND LINEARITY
A variable temperature load (VTL) or noise source including a grounded coplanar waveguide (GCPW) comprising a first metallization patterned on a fused quartz substrate, the first metallization comprising a first end for connecting to a coaxial connector and a second end for connecting to a coplanar waveguide (CPW); the CPW coupled to a 50 ohm termination and comprising a second metallization patterned on a top surface of a crystal quartz substrate; a temperature sensing diode thermally coupled to the crystal quartz substrate and the second metallization; and a heater resistor coupled to the crystal quartz substrate via contact metallization.
Photoacoustic imaging techniques that deliver diffuse light in transmission mode to the brain and detect acoustic waves transmitted through an acoustic window in the skull.
The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
The present application relates to hybridization chain reaction (HCR). In particular, compositions and methods are presented for ultrasensitive molecular detection using HCR signal amplification. Some embodiments and methods involve cooperative probe junctions, reporter-labeled probes, and nonlinear HCR signal amplification.
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
Some implementations of the disclosure relate to a wearable biosensor device including: a microfluidic module configured to collect a sweat sample from skin of a user, route the sweat sample to a sensing reservoir that is filled with the sweat sample, and route additional sweat away from the sensing reservoir when the sensing reservoir is filled; and a sensor assembly configured to quantify the biomarker of the sweat sample in the sensing reservoir to determine a concentration of the biomarker present in the sweat sample. The sensor assembly includes a biorecognition interface having a surface functionalized with an aptamer that binds to the biomarker.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures
87.
TECHNIQUES FOR BIDIRECTIONAL TRANSDUCTION OF QUANTUM LEVEL SIGNALS BETWEEN OPTICAL AND MICROWAVE FREQUENCIES USING A COMMON ACOUSTIC INTERMEDIARY
A device includes an opto-acoustic transducer configured to convert between an optical signal and an acoustic signal, an electro-acoustic transducer coupled to a microwave resonant circuit and configured to convert between an acoustic signal and a microwave signal, and an acoustic waveguide coupling the opto-acoustic transducer to the electro-acoustic transducer.
B81B 3/00 - Dispositifs comportant des éléments flexibles ou déformables, p. ex. comportant des membranes ou des lamelles élastiques
B82Y 10/00 - Nanotechnologie pour le traitement, le stockage ou la transmission d’informations, p. ex. calcul quantique ou logique à un électron
B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
B82Y 40/00 - Fabrication ou traitement des nanostructures
G01H 11/08 - Mesure des vibrations mécaniques ou des ondes ultrasonores, sonores ou infrasonores par détection des changements dans les propriétés électriques ou magnétiques par des moyens électriques utilisant des dispositifs piézo-électriques
G06N 10/00 - Informatique quantique, c.-à-d. traitement de l’information fondé sur des phénomènes de mécanique quantique
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G11C 13/02 - Mémoires numériques caractérisées par l'utilisation d'éléments d'emmagasinage non couverts par les groupes , ou utilisant des éléments dont le fonctionnement dépend d'un changement chimique
88.
METHOD AND SYSTEM FOR OBSERVING BRAIN STATES WITH FUNCTIONAL ULTRASOUND IMAGING AND A SONOLUCENT INTERFACE
A cranial implant that facilitates functional ultrasound imaging is disclosed. The example cranial implant replaces a section of a skull. The cranial implant in includes a support section shaped to replace a removed section of the skull. The implant includes a window of sonolucent material allowing functional ultrasound imaging through an ultrasound probe on the window. The window is shaped to allow access to a region of interest in the brain from the ultrasound probe.
Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.
A61B 5/245 - Détection de champs biomagnétiques, p. ex. de champs magnétiques produits par des courants bioélectriques spécialement adaptée aux signaux magnétoencéphalographiques [MEG]
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/06 - Dispositifs autres que ceux à radiation, pour détecter ou localiser les corps étrangers
90.
Si-SUBSTITUTED LITHIUM THIOBORATE MATERIAL WITH HIGH LITHIUM ION CONDUCTIVITY FOR USE AS SOLID-STATE ELECTROLYTE AND ELECTRODE ADDITIVE
Aspects disclosed herein include materials comprising: a lithium thioborate composition characterized by formula FX1: Li3−z[B+Q]1[S+G]3 (FX1); wherein Q is a first dopant being a substitute for B in the composition and being one or more elements each aliovalent with respect to B; wherein G is a second dopant being a substitute for S in the composition and being one or more elements each aliovalent with respect to S; wherein z is a number greater than 0 and less than or equal to 0.40, optionally less than or equal to 0.05; and wherein the composition comprises only the first dopant, only the second dopant, or both the first dopant and the second dopant.
Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.
A measurement device includes: a processing device and multiple sensors that capture tomographic information of a physiological structure. The sensors include a first sensor including a first transducer having a first frequency response with a first resonant frequency, and a second sensor including a second transducer having a second frequency response with a second resonant frequency different from the first resonant frequency. The first frequency response partially overlaps with the second frequency response. The second transducer transmits a signal that is reflected by the physiological structure to create a reflected signal, the first transducer generates a first received signal from the reflected signal, the second transducer generates a second received signal from the reflected signal, and the processing device normalizes the first received signal with the second received signal or the second received signal with the first received signal.
Disclosed herein include methods, compositions, and kits suitable for use in determining the interaction between proteins and their targets. In some embodiments, the determination of the interaction between proteins and their targets is quantitative and in a high throughput manner.
Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.
Systems and alloying methods for forming metals are described. Waste materials from various industrial processes and botched master alloy production heats result in numerous byproducts that can form constituent components for the formation of bulk alloys with higher value and more diverse applications. Reusing and upcycling industrial byproducts into material with specific structure and properties result in additional commercial and industrial applications and value.
Interferometric speckle visibility spectroscopy methods, systems, and non-transitory computer readable media for recovering sample speckle field data or a speckle field pattern from an off-axis interferogram recorded by one or more sensors over an exposure time and determining sample dynamics of a sample being analyzed from speckle statistics of the speckle field data or the speckle field pattern.
Systems and methods for thermal management using separable heat pipes and methods of manufacture thereof. Various embodiments provide a porous insert that can be used to join or connect heat pipes. Further embodiments provide thermal management systems that are modular, expandable, reparable, by allowing for joining of evaporators, condensers, and adiabatic sections via porous inserts. Various embodiments allow for two-phase thermal management systems, where liquid and gaseous phases can be transported simultaneously. Certain embodiments incorporate heat generating components with embedded evaporators and/or condensers. Many embodiments are additively manufactured, including via 3D printing.
F28D 15/02 - Appareils échangeurs de chaleur dans lesquels l'agent intermédiaire de transfert de chaleur en tubes fermés passe dans ou à travers les parois des canalisations dans lesquels l'agent se condense et s'évapore, p. ex. tubes caloporteurs
F28D 15/04 - Appareils échangeurs de chaleur dans lesquels l'agent intermédiaire de transfert de chaleur en tubes fermés passe dans ou à travers les parois des canalisations dans lesquels l'agent se condense et s'évapore, p. ex. tubes caloporteurs avec des tubes ayant une structure capillaire
The present disclosure describes a cavity accumulating the intensity of the laser beams reflecting within the cavity to build up power while also maintaining a relatively uniform intensity distribution. An apparatus comprising the cavity can be used to build up the power of the electromagnetic radiation for interacting with material, wherein the material does not substantially reflect or absorb the electromagnetic radiation.
The present application relates to hybridization chain reaction (HCR). In particular, the sensitivity of hybridization chain reaction (HCR) signal amplification is combined with two or more fractional-initiator probes and one or more proximity probes able to colocalize a full HCR initiator that will trigger HCR when the targets are in proximity to one another.
C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
brevets
