The United States of America, as represented by the Secretary, Dept. of Health and Human Services

United States of America

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Total IP 136
Total IP Rank # 9,769
IP Activity Score 2.8/5.0    83
IP Activity Rank # 8,278

Patents

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Last Patent 2025 - Antigen binding polypeptides, po...
First Patent 1984 - Pseudomonas exotoxin conjugate i...

Latest Inventions, Goods, Services

2025 Invention Antigen binding polypeptides, polypeptide complexes and methods of use thereof. Disclosed are an...
Invention Nk cells with an increased antibody-dependent cellular toxicity (adcc) against tumors. Disclosed...
2024 Invention Multi-cyclic irak and flt3 inhibiting compounds and uses thereof. Some embodiments of the disclos...
Invention Inhibitors of the surface expression of the voltage-gated sodium ion channel 1.7 (nav1.7) and the...
Invention Codon-optimized reduced-size atp7a cdna and uses for treatment of copper transport disorders. Di...
Invention Compositions and methods for producing dendritic cell-based vaccines with enhanced efficacy. Comp...
Invention Herv-e antibodies and methods of their use. Monoclonal antibodies and antigen binding fragments t...
Invention Multi-cyclic irak1 and irak4 inhibiting compounds and uses thereof. The present disclosure provid...
Invention Polypeptides, nucleic acid molecules, compositions, and related methods. Some embodiments of the...
Invention Nk cells or t cells expressing hematopoietic growth factor receptors and methods of use. Modifie...
2023 Invention Anti-b-cell maturation antigen chimeric antigen receptors with human domains. Provided are chime...
Invention Nk cells or t cells expressing chimeric hematopoietic growth factor receptors and methods of use....
Invention Novel crispr enzymes and systems. The invention provides for systems, methods, and compositions ...
Invention Anti-sars-cov-2 antigen binding polypeptides, polypeptide complexes and methods of use thereof. ...
Invention Treatment of fibrotic disorders with metabotropic glutamate receptor 5 antagonists or/and cannabi...
Invention Compositions and methods for detecting lymphatic filariasis. Compositions for detecting agents c...
Invention Systems and methods to identify and treat subjects at risk for obstetrical complications. Provide...
Invention Modified factor xa polypeptides and methods of use. Modified Factor Xa polypeptides having funct...
Invention Short apolipoprotein e mimetic peptides and methods of use. ApoE mimetic peptides of 8-17 amino ...
Invention Recombinant polypeptides comprising single-domain antibodies targeting herv-k subtype hml-2. The...
Invention Micrornas and methods of their use. Disclosed herein are methods of treating a tumor in a subjec...
Invention Compounds for improving mrna splicing. Provided herein are compounds useful for improving mRNA s...
Invention Methods and devices for collecting and analyzing aerosol particles. A device (200) for collecting...
2022 Invention N-((adamantan-1-yl)carbamoyl)-benzenesulfonamide derivatives as soluble epoxide hydrolase inhibit...
Invention Crystal structure of crispr cpf1. The invention provides for systems, methods, and compositions ...
Invention Augmentation of innate and adaptive immunity by inhibition of interaction of lilrbs with mhc-1. M...
Invention Methods and compositions for inhibiting polyomavirus-associated pathology. Disclosed herein are ...
Invention D3 dopamine receptor-selective negative allosteric modulators. Compounds of Formula I, Formula I...
Invention Vaccine candidates for human respiratory syncytial virus (rsv) having attenuated phenotypes. Repo...
Invention Method for inhibiting zika virus infection. The present invention concerns the use of compounds a...
Invention Short apoc-ii mimetic peptides and methods of use. ApoC-II mimetic peptides of 19-35 amino acids...
Invention Lipoprotein targeting protease inhibitors and uses. Described herein is the design and construct...
Invention Il-13ralpha2 targeted immunotoxins and methods of use. The disclosure relates to immunotoxins, p...
Invention Human insulin c-alpha-peptides and methods of use. Methods of treating a subject with diabetes o...
Invention Il-13ra2 chimeric antigen receptors and methods of use. Immunotherapies, particularly chimeric a...
Invention Adjuvanted mucosal subunit vaccines for preventing sars-cov-2 transmission and infection. Immuno...
2021 Invention Multi-cyclic irak and flt3 inhibiting compounds and uses thereof. Some embodiments of the disclo...
Invention Single-cell profiling of chromatin occupancy and rna sequencing. Compositions and methods for de...
Invention Modified nk cells with reduced ccr5 expression and methods of their use. Modified NK cells with ...
Invention Synthetic lethality-mediated precision oncology via tumor transcriptome. The present disclosure ...
Invention Methotrexate analogs and methods of use. Compounds having general formula I Compounds having g...
Invention Alk2 inhibitors and methods for inhibiting bmp signaling. The present invention provides small-mo...
Invention Margaric acid decreases piez02-mediated pain. Described herein is a method of treating pain by a...
Invention Methods and systems for predicting rates of progression of age-related macular degeneration. Dis...
Invention Use of statins to treat or prevent drug-induced hearing loss. The invention relates to methods a...
2020 Invention Cd206 modulators their use and methods for preparation. Compounds of Formula I, Formula II, and ...
Invention T-cell compositions and methods of making and using the same. The present disclosure provides ad...
Invention Cd28h domain-containing chimeric antigen receptors and methods of use. Chimeric antigen receptor...