The United States of America, as represented by the Secretary, Department of Health and Human Services

United States of America

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Total IP 2,866
Total IP Rank # 434
IP Activity Score 3.8/5.0    1,307
IP Activity Rank # 555

Patents

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Last Patent 2025 - Multidimensional mri signature f...
First Patent 1982 - Method for reducing toxic effect...

Latest Inventions, Goods, Services

2025 Invention Multidimensional mri signature for specific detection of traumatic brain injury in vivo. Multidi...
Invention Thermo-sensitive anti-fungal hydrogel compositions and methods of use. A hydrogel composition for...
Invention Single-domain antibodies and bispecific antibodies against hiv-1 and their use. Bispecific antibo...
Invention Systems for integrated imaging and multi-view augmented reality for surgical intervention. System...
Invention Treatment of cardiovascular disease with antxr1 antibodies. Disclosed herein are antibodies and a...
Invention Dynamic assessment of cellular metabolism through optical imaging and artificial intelligence tec...
Invention Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof. Monoclo...
Invention Multi-well dialysis microplate. A sampling microplate or tray for conducting dialysis of a fluid ...
Invention Synthetic gba1 genes. coGBA1coGBA1GBA1GBA1 mutations, are also described.
Invention Predicting dna methylation and tumor types from histopathology. Disclosed herein are systems and ...
Invention Enhanced tumor reactivity of t cells lacking sit1, lax1, or trat1. SIT1, LAX1 TRAT1. TRAT1. Relat...
Invention Embolic microspheres. Functionalized embolic microspheres may be employed as a platform for radio...
Invention Novel compositions of matter comprising proteins that incorporate pfs230 or pvs230 domain 1 (pfs2...
Invention Use of lmo4 to bolster stemness and antitumor efficacy of t-cells. The present invention relates ...
2024 Invention Broadly neutralizing antibodies against sars-cov-2 and sars-cov variants. Disclosed are monoclona...
Invention N-methyltransferase and their therapeutic uses. NN-methyltransferase (NNMT) which have a triazolo...
Invention Oxabicycloheptanes for modulation of immune response. The present invention provides a method of...
Invention Rsv vaccine bearing a polynucleotide which is de-optimised and de-attenuated. Provided is a polyn...
Invention Systems and methods for clinical artificial intelligence with patient-reported multi-modal audio ...
Invention Quantitative optical coherence tomography angiography. By acquiring sequences of data associated ...
Invention Modified pigment epithelium-derived factor peptides and methods of use. Provided herein are compo...
Invention Broadly neutralizing influenza hemagglutinin stem-directed antibodies. Monoclonal antibodies and ...
Invention Development of broad-spectrum anti-opioid vaccines. Provided herein are vaccine compositions comp...
Invention Neutralizing and protective monoclonal antibodies against respiratory syncytial virus (rsv). Anti...
Invention Influenza neuraminidase active site proximity assay (naspa) for rapid profiling of inhibitory ant...
Invention Immunogenic compositions comprising full-length influenza virus neuraminidase protein subunits an...
Invention Dna methylation-based cancer diagnostics. Disclosed herein are methods for classifying a tumor us...
Invention Prazole-based antiviral therapeutics. 161622nn- group where n is an integer from 1 to 6, a divale...
Invention Three-dimensional tuberculoma bioplatform and uses thereof. Provided herein is a 3-dimensional bi...
Invention Fused heterocycles for treating neurodegenerative diseases. Disclosed herein are aspects of compo...
Invention Nk cells or t cells expressing chimeric hematopoietic growth factor receptors and methods of use....
Invention Brincidofovir for treatment of multiple sclerosis. The invention features methods of treating mul...
Invention Bioreactor system. A bioreactor vessel platform for submersion in a bioreactor vessel or petri di...
Invention Analogues of n-lactoyl-phenylalanine, methods of synthesis, and methods of use. N-Lactoyl-Phenyla...
Invention A molecular scaffold for depleting hrpn13 and a select group of ken box proteins. The invention p...
Invention Gait assistance systems and methods of control thereof. Determining predicted torque values for a...
Invention Stabilized sars-cov-2 s antigens. Provided herein are engineered protein comprising stabilized co...
Invention Human parainfluenza virus immunogenic molecules. Disclosed are live-attenuated human parainfluenz...
Invention Viral strain serology assays. The invention relates to methods and kits for determining a SARS-Co...
Invention Using machine learning and/or neural networks to validate stem cells and their derivatives (2-d c...
Invention Nanoparticle-hydrogel composite for nucleic acid molecule delivery. This disclosure provides nove...
2023 Invention Combination of angubindin-1 abd chemotherapy for the treatment of cns malignancies. The invention...
Invention Fused diazepines as agonists of the insulin-like 3 (insl3) peptide receptor rxfp2 and methods of ...
Invention Preparation of isotopically labeled ketoglutarates and methods of hyperpolarization through signa...
Invention Gingerenone a prodrugs as sensotherapeutics and methods of use. B is an amino acid side chain. Th...
2022 Invention Improved gene therapy constructs for the treatment of propionic acidemia caused by mutations in p...
Invention Next generation transpososomes. Disclosed herein is a modified transposase, comprising a core pi...
Invention Methods and systems for analyzing target engagement data from biological assays. The disclosure ...
Invention Self-assembling nanoparticles based on amphiphilic peptides. The present disclosure relates to a...
2017 Invention Compositions comprising pregnancy specific glycoproteins and methods of use thereof. The present ...