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2019
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Invention
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Humanized and de-immunized antibodies. The invention relates to humanized and de-immunized antibo... |
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2018
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Invention
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Inhibitors of glutaminyl cyclase. The invention relates to a compound of formula (I): Formula (I)... |
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Invention
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Novel inhibitors. The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceut... |
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2016
|
Invention
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Glutaminyl cyclase as a diagnostic/prognostic indicator for neurodegenerative diseases.
A method... |
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Invention
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Anti-pyroglutamated amyloid beta humanized antibodies. The invention relates to humanized antibod... |
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2015
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Invention
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Novel method for the detection of pglu-abeta peptides.
The invention relates to a highly sensiti... |
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Invention
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Novel method for the detection of pglu-abeta peptides. The invention relates to a highly sensitiv... |
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Invention
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Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (mcp-1 n1pe).
Monoc... |
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Invention
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Transgenic mouse expressing human isoglutaminyl cyclotransferase.
A transgenic non-human animal ... |
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2014
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Invention
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Radiolabelled glutaminyl cyclase (qc) inhibitors and uses of same. Radiolabeled glutaminylcyclase... |
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Invention
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Novel inhibitors. The invention relates to a compound of formula (I) or a pharmaceutically accept... |
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2013
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Invention
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Mouse models carrying a knock-out mutation of the qpctl-gene. A knock-out non-human animal, in pa... |
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Invention
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Crystal structure of glutaminyl cyclase. Novel crystal structures of human and murine glutaminyl ... |
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2012
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Invention
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In vivo screening models for treatment of qc-related disorders.
A double transgenic non-human an... |
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Invention
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In vivo screening models for treatment of qc-related disorders. The present invention provides a ... |
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Invention
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Radiolabelled glutaminyl cyclase inhibitors. The invention relates to the use of radiolabelled gl... |
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Invention
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Radiolabeled glutaminyl cyclase (qc) inhibitors and uses of same. Radiolabeled glutaminylcyclase ... |
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Invention
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Diagnostic antibody assay. The present invention pertains to novel diagnostic assays for the diag... |
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Invention
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Benz imidazole derivatives as inhibitors of glutaminyl cyclase. The invention relates to novel he... |
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Invention
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Methods of treating or preventing an inflammatory disease or condition using glutaminyl cyclase i... |
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2011
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Invention
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Screening method for enzyme inhibitors. Novel glutaminyl-peptide cyclotransferase-like proteins (... |
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Invention
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Crystal structure of isoglutaminyl cyclase. The invention relates to novel crystal structures of ... |
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Invention
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Crystal structure of isoglutaminyl cyclase. A crystal comprising human isoglutaminyl cyclase havi... |
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Invention
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In vivo screening models for treatment of isoqc-related disorders.
A transgenic non-human animal... |
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Invention
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In vivo screening models for treatment of isoqc-related disorders. The present invention provides... |
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Invention
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Crystal structure of glutaminyl cyclase. The invention relates to novel crystal structures of hum... |
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Invention
|
Crystal structure of glutaminyl cyclase. A novel crystal structures of human and murine glutaminy... |
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Invention
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Benzimidazole derivatives as inhibitors of glutaminyl cyclase. The invention relates to novel het... |
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Invention
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Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5). The invention relates to novel he... |
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Invention
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Inhibitors of glutaminyl cyclase. The invention relates to novel heterocyclic derivatives as inhi... |
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Invention
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Novel diagnostic method.
A method of monitoring treatment of an inflammatory disease or an infla... |
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Invention
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Methods of diagnosing inflammatory diseases by determining pyroglutamate-modified mcp-1 and scree... |
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2010
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Invention
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Cleavage of β-amyloid precursor protein. The present invention concerns methods and means for the... |
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Invention
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Cleavage of b-amyloid precursor protein.
Methods and means for the identification of meprin-α an... |
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Invention
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Novel diagnostic method.
Provided herein are methods, compositions, and kits related to the dete... |
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Invention
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Novel diagnostic method for the diagnosis of alzheimer's disease or mild cognitive impairment. Th... |
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Invention
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Novel assay.
A novel method for detection of Aβ peptides, in particular in plasma, and to the us... |
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Invention
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Novel assay for the detection of amyloid beta peptides. The present invention pertains to a novel... |
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Invention
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Heterocylcic derivatives as inhibitors of glutaminyl cyclase. The invention relates to novel pyrr... |
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Invention
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Mouse models carrying a knock-out mutation of the qpctl-gene. The present invention provide... |
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Invention
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Mouse models carrying a knock-out mutation of the qpctl-gene. The present invention provides a kn... |
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Invention
|
Mouse models carrying a knock-out mutation of the qpctl-gene.
A knock-out non-human animal, in p... |
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Invention
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Enzyme inhibitors.
There is disclosed herein methods for using compounds of formula (I),
There... |
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2009
|
Invention
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Combinations useful for the treatment of neuronal disorders.
The present invention provides a me... |
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2008
|
Invention
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Novel compounds.
The invention provides compounds of general formula (I)
The invention provide... |
