The present invention relates to a device (2) for sequencing a protein (4) or part thereof, comprising a substrate (6) comprising a first pore (16), the pore providing or adjacent a plasmonic hotspot (22) such that a protein (4) passing through the hotspot (22) can be sequenced using Raman spectroscopy in use. A second pore (18) fluidly connected to and spaced from the first pore (16) and configured to receive the protein (4). The device (2) comprises a means (34A,B) to bias said protein (4) toward the first pore (16) and/or second pore (18), such that the protein (4) passing through the hotspot (22) is at least partially uncoiled, unfolded or otherwise linearised.
The present invention relates to a method of characterising a protein (4) or part thereof comprising: extracting a one or more protein (4) and adsorbing the protein (4) onto a nanoparticle (14). A substrate (16) is provided having one or more well (18) configured to receive a nanoparticle (14) comprising the protein (4), the well (18) and the respective nanoparticle (14) configured to provide a plasmonic hotspot. Raman spectroscopy is used to characterise the protein (4) located on the nanoparticle (14).
According to an aspect of the present invention, there is provided a [1,2,4]triazolo[3,4-b]benzothiazole scaffold, which can be used to inhibit efficiently human PARP enzymes. The compounds disclosed bind to the nicotinamide pocket of the enzyme and compete with the natural substrate, NAD*. The present compounds are new types of nicotinamide mimics with wide use as new therapeutics especially against cancer.
A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
The present invention is directed to sulfur-bridged difuran polyesters comprising a dicarboxylate component and a diol component. The present invention is further directed to films, coatings, packaging materials or packages comprising said sulfur-bridged difuran polyesters. Also, production methods for said polyesters are provided. Further, the invention provides sulfur-bridged difuran compounds and their use in the preparation of polymers having ultraviolet light (UV) blocking properties. The invention is also directed to curable resin compositions comprising said sulfur-bridged difuran compounds.
A radio frequency imaging apparatus comprises a radio frequency receiver (16), which receives radio frequency electromagnetic radiation interacted with a non-stationary object (12) and forms, as a function of time, at least one property of the radio frequency radiation interacted with the object (12), the non-stationarity of the object (12) relating to at least one of the following: a direction from which the radio frequency radiation hits the object (12), a position of the receiver (16). A data gathering unit (18) gathers information on position and/or orientation of the object (12) as a function of time, and forms, as a function of time, information on position and/or orientation of the object (12) within the radio frequency radiation from the gathered data. A data processing unit (10) forms at least one radio frequency image of the object (12) from both of said information on position and/or orientation of the object (12) and the at least one property of the radio frequency radiation interacted with the object (12), the data processing unit (10) utilizing temporal relation between the at least one radio frequency property and information on the position and/or orientation of the object (12) in formation of the radio frequency image.
G01S 13/89 - Radar or analogous systems, specially adapted for specific applications for mapping or imaging
G01S 7/41 - Details of systems according to groups , , of systems according to group using analysis of echo signal for target characterisationTarget signatureTarget cross-section
G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
G01S 13/50 - Systems of measurement based on relative movement of target
G01S 13/72 - Radar-tracking systemsAnalogous systems for two-dimensional tracking, e.g. combination of angle and range tracking, track-while-scan radar
G01S 13/86 - Combinations of radar systems with non-radar systems, e.g. sonar, direction finder
6.
MANUFACTURING AN ELECTROCERAMIC COMPOSITE STRUCTURE
A method is disclosed for manufacturing a hollow electroceramic composite structure (101), comprising providing sacrificial material (102) comprising water-soluble salt, compressed into a desired shape. A combination (101) of electroceramic powder and flowable metal oxide precursor is placed on a surface of the compressed sacrificial material (102), and a pressure of 100 - 500 MPa is applied to said combination (101). The combination (101) is exposed, under said pressure to a heat treatment at a temperature of 20°C to 500°C, for a predefined time period, for forming electroceramic composite material (101) on the surface of the sacrificial material (102), wherein at least part of the sacrificial material is allowed to react with the metal oxide precursor to form metal oxide in the electroceramic composite material. Optionally any unreacted sacrificial material is removed from the electroceramic composite material by treatment with water. The allowing of the at least part of the sacrificial material (102) to react with the metal oxide precursor to form the metal oxide in the electroceramic composite material comprises that crystal water contained in the hydrated salt in the sacrificial material (102) is reacted with the metal oxide precursor to form the metal oxide in the electroceramic composite material.
C04B 35/26 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on ferrites
C04B 35/468 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates based on titanates based on alkaline earth metal titanates based on barium titanates
C04B 35/47 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates based on titanates based on alkaline earth metal titanates based on strontium titanates
C04B 35/491 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates containing also titanium oxide or titanates based on lead zirconates and lead titanates
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
A process for post-treatment of electroceramic composite material is disclosed. The process comprises introducing electroceramic composite material and flow-able organometallic compound to a pressure chamber, and degassing (1) the electroceramic composite material by creating a vacuum or underpressure in the pressure chamber, while the electroceramic composite material is immersed (2) in said organometallic compound. Then the pressure is elevated to an atmospheric pressure, wherein said flowable organometallic compound is absorbed (3) into at least part of the pores of the composite material. The electroceramic composite material containing said organometallic compound absorbed into said pores, is then treated (4) with water, water vapour and/or other chemical, thereby producing metal oxide impregnated electroceramic material containing solid metal oxide absorbed into said pores. Instead of flowable organometallic compound, a suspension of metal or metal oxide nanoparticles may be used for the post-treatment.
C04B 35/491 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates containing also titanium oxide or titanates based on lead zirconates and lead titanates
C04B 35/626 - Preparing or treating the powders individually or as batches
H01B 3/12 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of inorganic substances ceramics
An optical apparatus for measuring fluid flow within a living tissue (10) comprises an optical radiation source (12) that outputs an optical pulse into the tissue (10) at successive moments. At least one first array (14A) of single-photon avalanche detectors detect, for each of the successive moments of the outputs of the optical pulse, photons from an interaction between the optical pulse and the fluid flow at a first location of the flow. At least one second array (14B) of single single-photon avalanche detectors detect, for each of the successive moments of the successive outputs of the optical pulse, photons from interaction between the optical pulse and the fluid flow at second location of the flow, the second location being in an upstream or downstream location with respect to the first location. A data processing circuitry (16) determines a speed of the flow based on a known spatial distance between the at least one first and second array (14A, 14B), and a similarity between numbers of photons detected by the at least one first and second array (14A, 14B) at a plurality of moments of outputs of the optical pulse.
The present invention is directed to a method, kit, system and fusion protein for detecting binding to an ADP-ribosyl group or a polymer thereof, wherein said group or polymer is coupled to a peptide or protein, the method comprising the steps of: i) providing a first entity comprising a first label or tag, said entity comprising an amino acid sequence comprising a cysteine residue whereto at least one ADP-ribosyl group or an analog thereof is coupled via an S-glycosidic bond; ii) contacting in an assay said first entity with a second entity, said second entity being or suspected of being capable of binding to an ADP-ribosyl group or polymer thereof coupled to a peptide or protein; and iii) measuring a signal derived from said first label or localized by said tag, wherein the signal detected is different or is localized differently when said second entity binds to said at least one ADP-ribosyl group of the first entity from the signal detected when the binding interaction between said second entity and said ADP-ribosyl group has not occurred. The kit of the present invention provides means to perform the method of the invention.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
10.
SELF-HEALING ELASTOMERS AND METHOD OF MAKING THE SAME
The invention relates to a method for manufacturing a self-healing elastomer, comprising preparing, with respect to the total weight of the self-healing elastomer, 0.1-5 wt. % of boron trioxide (B2O3), 65-90 wt. % of hydroxyl-terminated polydimethylsiloxane (PDMS-OH), 5-30 wt. %, when measured in combined, of polysiloxane precursors, being a first composition comprising a siloxane base, and a second composition comprising a siloxane crosslinker, wherein the ratio by weight of the first composition and the second composition is 1:1 to 50:1; homogeneously mixing B2O3, PDMS-OH, and the first composition, thereby obtaining a mixture, reacting the mixture and the second composition at an elevated temperature ranging from 60° C. to 150° C., endpoints inclusive, thereby obtaining the self-healing elastomer.
An apparatus for measuring intracranial dynamics comprises the at least one sensing device (100): an electroencephalo-graphic electrode arrangement, which senses direct-current electroencephalographic signals from the brain, an optic measurement Marrangement (120), which directs optic radiation toward the brain through the cranium, and receives the optic radiation reflected and/or scattered therefrom, and/or a capacitive sensor arrangement (130), which senses electric potential signals of the head. The apparatus additionally comprises a data processing arrangement (150), which receives electric signals from the at least one sensing device (100), and determine data on at least one of the following dynamics: glymphatic activity, water within the cranium, brain tissue movements, water and/or electrolyte movements and intracranial pressure based on said electric signals from the at least one sensing device (100). The data processing arrangement (150) then outputs at least one piece of the data on the dynamics through a user interface (152).
The invention relates to a method for manufacturing a self-healing elastomer, comprising preparing, with respect to the total weight of the self-healing elastomer, 0.1-5 wt. % of boron trioxide (B2O3), 65-90 wt. % of hydroxyl-terminated polydimethylsiloxane (PDMS-OH), 5-30 wt. %, when measured in combined, of polysiloxane precursors, being a first composition comprising a siloxane base, and a second composition comprising a siloxane crosslinker, wherein the ratio by weight of the first composition and the second composition is 1:1 to 50:1; reacting B2O3 and PDMS-OH at an elevated temperature ranging from 60° C. to 200° C., endpoints inclusive, thereby obtaining a first mixture, mixing the first mixture with an alcohol, and then the first composition, thereby obtaining a second mixture, reacting the second mixture and the second composition, thereby obtaining the self-healing elastomer.
An optoelectronic apparatus for measuring organic tissue is attached with the organic tissue. A semiconductor optic radiation source outputs repeatedly infrared pulses of toward the tissue. An array of single-photon avalanche diodes is directed toward the tissue and detects photons of the optical pulses that have interacted with the tissue. A timing unit determines time-of-flights of photons of each of the optical pulses within a temporal measurement range after an output of each of the optical pulses. A data processing unit estimates a physiological state of the tissue within at least one time window shorter than the temporal measurement range based on at least one of the following: a number of the detections within the time window and a distribution of the detections within the time window.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
14.
OPTICAL APPARATUS AND METHOD FOR MEASURING A PLURALITY OF TARGETS USING A SINGLE PHOTON AVALANCHE DETECTOR
An optical source (100) generates optical pulses, and directs them to a first path arrangement (102), which splits and directs them to targets (104, 106). A second path arrangement (108) transfers the optical radiation to a wavelength separator (110), which directs wavelengths to SPAD elements of a detector (112). Unique propagation delays cause receptions of the optical radiation to separate temporally at the SPAD elements. A timing controller (114) triggers detection intervals of the SPAD elements ON/OFF synchronously with the delays of the paths (102, 108) and generation of the pulses, and allows the SPAD elements to detect photons only during the detection intervals that are temporally matched with the interactions. The SPAD elements output electric signals synchronously with the detection intervals for causing them to correspond to distribution of wavelengths of the optical radiation of only one of the targets (104, 106) at each output moment.
A method for measuring intracranial dynamics, by performing (2200) an optoelectronic measurement of the intracranial neuronal and fluids dynamics, brain tissue pulsation and glymphatic activity through the cranium by an optoelectronic measurement arrangement (120). Applying (2202), by the data processing unit (150), at least one of the following analyses to electrical signals received from the optoelectronic measurement arrangement (120) and carrying information on said dynamics. At least one of the pulses of the of the dynamics is decomposed for processing with a relation between the characteristic pulses. A moment of statistical analysis of the pulses of said dynamics is determined. A brain fluid, particularly water-hemodynamic, coupling is determined from the pulses of said dynamics based on a definition that a sum of volumes of the brain tissue, cerebrospinal fluid (CSF) and intracranial blood is constant. A ratio between a power spectral density of a fraction of a whole measured frequency band and a power spectral density of the whole measured frequency band is determined. Entropy relating to the electrical signals is determined. A G-index based on said analysis of the electrical signals and a reference, which is based on an analysis of a control group with known and/or estimated intracranial dynamics, is determined, the G-index representing a relative dynamics of the brain.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/374 - Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
16.
MANUFACTURING COMPOSITE ELECTROCERAMICS USING WASTE ELECTROCERAMICS
A method for manufacturing composite electroceramics comprises obtaining recycled capacitors, coils, resistors, conductors circuit boards, and/or other recycled electronic components. The components may be grinded into a particles having a particle size below 2 mm, and mixed with NaCl powder or Li2MoO4 or other watersoluble ceramic powder having a particle size of 5-200 microns, in a ratio of 10-40 vol-% optionally grinded components, and 60-90 vol-% NaCl powder or Li2MoO4 or other ceramic powder. The obtained solids mixture is mixed with aqueous solution of NaCl, Li2MoO4 or said other ceramic, in a ratio of 70-90 wt-% solids mixture, and 10-30 wt-% aqueous solution. The obtained homogeneous mass is compressed in a mould for 2-10 min, in room temperature, in a pressure of 100-400 MPa. The compressed mass is removed from the mould, thereby obtaining electroceramic composite material. Alternatively to the use of the water soluble salt an organometallic precursor compound can be used.
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
A method for manufacturing composite electroceramics comprises obtaining sintered electroceramic waste material. The waste material is grinded to obtain first ceramic powder having a particle size of 10-400 micron. The first ceramic powder is mixed with NaCl, Li2MoO4 or other ceramic powder having a particle size of 0.5-20 micron, in a ratio of 60-90 vol-% said first ceramic powder and 10-40 vol-% NaCl, Li2MoO4 or other ceramic powder. The obtained ceramic powder mixture is mixed with aqueous solution of NaCl, Li2MoO4 or said other ceramic, in a ratio of 70-90 wt-% the ceramic powder mixture, and 10-30 wt-% the aqueous solution. The obtained homogeneous mass is compressed in a mould for 2-10 min in room temperature and in a pressure of 100-400 MPa. The compressed homogeneous mass is removed from the mould, thereby obtaining electroceramic composite material. Alternatively to the use of the water soluble salt an organometallic precursor compound can be used.
A method is disclosed for treatment and utilization of green liquor dregs. The method comprises obtaining green liquor dregs originating from a pulp process. The green liquor dregs are dried at a temperature of 95 to 120 °C, preferably at 100 °C, to obtain dried green liquor dregs. The dried green liquor dregs are calcined for 1 to 4 hours, preferably for 2 hours, at a temperature of 800 to 1200 °C, preferably at 800 to 1000 °C, to obtain calcined green liquor dregs. The calcined green liquor dregs are used to control the pH of a flotation process in mining industry.
Apparatus, method and computer program code for processing computed tomography (CT) scan data is disclosed. The method includes: receiving (202) a real sinogram from a CT scanning of a region of interest of a subject; receiving (204) shape data representing anatomic contours of a body part containing the region of interest of the subject; retrieving (206) a template sinogram from among a plurality of stored template sinograms based on the anatomic contours of the body part; performing (210) an image registration between the real sinogram and the template sinogram to obtain a registered template sinogram; and generating (212) an enlarged sinogram from the real sinogram by adding the non-overlapping parts from the registered template sinogram.
According to an aspect of the present invention, there is provided a [1,2,4]triazolo[3,4-b]benzothiazole scaffold, which can be used to inhibit efficiently human PARP enzymes. The compounds disclosed bind to the nicotinamide pocket of the enzyme and compete with the natural substrate, NAD+. The present compounds are new types of nicotinamide mimics with wide use as new therapeutics especially against cancer.
A61K 31/429 - Thiazoles condensed with heterocyclic ring systems
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
C07D 417/02 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings
C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
21.
NEEDLE APPARATUS, METHODS OF PERFORMING SAMPLING THEREWITH AND OF MANUFACTURING THEREOF
A needle apparatus (10) for taking a sample from inside of an object comprises a stylet (100), which comprises a longitudinal hollow (102). A transmission fiber arrangement (104) and a reception fiber arrangement (112) are on a bottom (126) of a surface (106) of the hollow (102). A first end (108) of the transmission fiber arrangement (104) is at an access tip (110) of the stylet (100). The transmission fiber arrangement (104) guides optical radiation from a second end (120) of the transmission fiber arrangement (104) to the first end (108) and output the optical radiation therefrom. A first end (114) of the reception fiber arrangement (112) is located at the access tip (110). The reception fiber arrangement (112) receives optical radiation from environment of the access tip (110) and guides the optical radiation therefrom to a second end (122) of the reception fiber arrangement (114) and outputs the optical radiation from there.
The current invention describes a method of manufacturing a porous dielectric material, the method comprising (a) providing a porous template, (b) coating the porous template with an inorganic dielectric material or a precursor of an inorganic dielectric material to form a coated porous template, (c) treating the coated porous template to remove the porous template and to form a porous structure of dielectric material from the coating of inorganic dielectric material or precursor of an inorganic dielectric material, and (d) combining the formed porous structure of dielectric material with a coating polymer to form the porous dielectric material. The invention also relates to RF components on a substrate material, with a conductive material deposited on a porous dielectric material.
H01P 1/20 - Frequency-selective devices, e.g. filters
H01P 11/00 - Apparatus or processes specially adapted for manufacturing waveguides or resonators, lines, or other devices of the waveguide type
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
C23C 14/04 - Coating on selected surface areas, e.g. using masks
C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
23.
SULFUR-BRIDGED THERMOPLASTIC POLYESTERS AND THERMOSETS FROM FURFURAL
The present invention is directed to sulfur-bridged difuran polyesters comprising a dicarboxylate component and a diol component. The present invention is further directed to films, coatings, packaging materials or packages comprising said sulfur-bridged difuran polyesters. Also, production methods for said polyesters are provided. Further, the invention provides sulfur-bridged difuran compounds and their use in the preparation of polymers having ultraviolet light (UV) blocking properties. The invention is also directed to curable resin compositions comprising said sulfur-bridged difuran compounds.
A radio frequency imaging apparatus comprises a radio frequency receiver (16), which receives radio frequency electromagnetic radiation interacted with a non-stationary object (12) and forms, as a function of time, at least one property of the radio frequency radiation interacted with the object (12), the non-stationarity of the object (12) relating to at least one of the following: a direction from which the radio frequency radiation hits the object (12), a position of the receiver (16). A data gathering unit (18) gathers information on position and/or orientation of the object (12) as a function of time, and forms, as a function of time, information on position and/or orientation of the object (12) within the radio frequency radiation from the gathered data. A data processing unit (10) forms at least one radio frequency image of the object (12) from both of said information on position and/or orientation of the object (12) and the at least one property of the radio frequency radiation interacted with the object (12), the data processing unit (10) utilizing temporal relation between the at least one radio frequency property and information on the position and/or orientation of the object (12) in formation of the radio frequency image.
G01S 13/00 - Systems using the reflection or reradiation of radio waves, e.g. radar systemsAnalogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
G01S 13/50 - Systems of measurement based on relative movement of target
G01S 7/02 - Details of systems according to groups , , of systems according to group
A process for manufacturing ceramic-metal composite material, comprises dissolving ceramic powder into water to obtain an aqueous solution of ceramic; mixing metal powder having a multimodal particle size where largest particle size is one fourth of the minimum dimension of a device, with the aqueous solution of ceramic to obtain a powder containing ceramic precipitated on the surface of metal particles; mixing the powder containing ceramic precipitated on the surface of the metal particles, with ceramic powder having a particle size below 50 μm, to obtain a powder mixture; adding saturated aqueous solution of ceramic to the powder mixture to obtain an aqueous composition containing ceramic and metal; compressing the aqueous composition to form a disc of ceramic-metal composite material containing ceramic and metal; and removing water from the ceramic-metal composite material; wherein ceramic content of the disc is 10 vol-% to 35 vol-%. Alternatively, ceramic-ceramic composite material may be manufactured.
C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C22C 1/051 - Making hard metals based on borides, carbides, nitrides, oxides or silicidesPreparation of the powder mixture used as the starting material therefor
C22C 32/00 - Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
B22F 1/052 - Metallic powder characterised by the size or surface area of the particles characterised by a mixture of particles of different sizes or by the particle size distribution
A process for post-treatment of electroceramic composite material is disclosed. The process comprises introducing electroceramic composite material and flow-able organometallic compound to a pressure chamber, and degassing (1) the electroceramic composite material by creating a vacuum or underpressure in the pressure chamber, while the electroceramic composite material is immersed (2) in said organometallic compound. Then the pressure is elevated to an atmospheric pressure, wherein said flowable organometallic compound is absorbed (3) into at least part of the pores of the composite material. The electroceramic composite material containing said organometallic compound absorbed into said pores, is then treated (4) with water, water vapour and/or other chemical, thereby producing metal oxide impregnated electroceramic material containing solid metal oxide absorbed into said pores. Instead of flowable organometallic compound, a suspension of metal or metal oxide nanoparticles may be used for the post-treatment.
C04B 35/491 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates containing also titanium oxide or titanates based on lead zirconates and lead titanates
27.
ELECTROCERAMIC COMPOSITE MATERIAL AND METHOD OF MANUFACTURING IT
A method of manufacturing ceramic composite material comprises forming a combination of flowable metal oxide precursor (102), which is water-insoluble, and electroceramic powder (104) for covering surfaces of the electroceramic particles (500) with the metal oxide precursor (102), the electroceramic powder (104). A major fraction of the particles (500) has particle diameters within a range 50 μm to 200 μm, and a minor fraction of the particles has diameters smaller than the lower limit of said range, the major fraction having a variety of particle diameters. Then pressure 100 MPa to 500 MPa is applied to said combination, and said combination is exposed, under the pressure, to a heat treatment, which has a maximum temperature within 100° C. to 500° C. for a predefined period for forming the ceramic composite material.
C04B 35/462 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates based on titanates
C04B 35/626 - Preparing or treating the powders individually or as batches
C04B 40/02 - Selection of the hardening environment
C04B 41/00 - After-treatment of mortars, concrete, artificial stone or ceramicsTreatment of natural stone
28.
INORGANIC SOLID MATERIAL PROCESSING METHOD AND APPARATUS
Structure of inorganic solid material is mechanically broken, inorganic solid material including ammonia or one or more compound including nitrogen. The inorganic solid material is treated with fluid including water for hours and dried in order to reduce ammonia emission from the inorganic solid material thereafter.
B09B 3/00 - Destroying solid waste or transforming solid waste into something useful or harmless
C04B 28/00 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
23233, PDMS-OH, and the first composition (201a), thereby obtaining a mixture (301), reacting the mixture (301) and the second composition (201b) at an elevated temperature ranging from 60 °C to 150 °C, endpoints inclusive, thereby obtaining the self-healing elastomer (200).
The present invention is directed to a method, kit, system and fusion protein for detecting binding to an ADP-ribosyl group or a polymer thereof, wherein said group or polymer is coupled to a peptide or protein, the method comprising the steps of: i) providing a first entity comprising a first label or tag, said entity comprising an amino acid sequence comprising a cysteine residue whereto at least one ADP-ribosyl group or an analog thereof is coupled via an S-glycosidic bond; ii) contacting in an assay said first entity with a second entity, said second entity being or suspected of being capable of binding to an ADP-ribosyl group or polymer thereof coupled to a peptide or protein; and iii) measuring a signal derived from said first label or localized by said tag, wherein the signal detected is different or is localized differently when said second entity binds to said at least one ADP-ribosyl group of the first entity from the signal detected when the binding interaction between said second entity and said ADP-ribosyl group has not occurred. The kit of the present invention provides means to perform the method of the invention.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
31.
SELF-HEALING ELASTOMERS AND METHOD OF MAKING THE SAME
The invention relates to a method for manufacturing a self-healing elastomer (100), comprising preparing, with respect to the total weight of the self-healing elastomer (100), 0.1 - 5 wt.% of boron trioxide (B2O3), 65 - 90 wt.% of hydroxyl- terminated polydimethylsiloxane (PDMS-OH), 5 – 30 wt.%, when measured in combined, of polysiloxane precursors (201), being a first composition (201a) comprising a siloxane base, and a second composition (201b) comprising a siloxane crosslinker, wherein the ratio by weight of the first composition (201a) and the second composition (201b) is 1:1 to 50:1; reacting B2O3 and PDMS- OH at an elevated temperature ranging from 60 ˚C to 200 ˚C, endpoints inclusive, thereby obtaining a first mixture (101), mixing the first mixture (101) with an alcohol, and then the first composition (201a), thereby obtaining a second mixture (102), reacting the second mixture (102) and the second composition (201b), thereby obtaining the self-healing elastomer (100).
C08L 83/14 - Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon onlyCompositions of derivatives of such polymers in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
32.
OPTOELECTRONIC APPARATUS FOR AND METHOD OF MEASURING ORGANIC TISSUE
An optoelectronic apparatus for measuring organic tissue is attached with the organic tissue. A semiconductor optic radiation source (102) outputs repeatedly infrared pulses of toward the tissue. An array (106) of single-photon avalanche diodes (400) is directed toward the tissue and detects photons of the optical pulses that have interacted with the tissue. Atiming unit (108) determines time-of-flights of photons of each of the optical pulses within a temporal measurement range after an output of each of the optical pulses. A data processing unit (110) estimates a physiological state of the tissue within at least one time window (504, 506, 508) shorter than the temporal measurement range (510) based on at least one of the following: a number of the detections within the time window (504, 506, 508) and a distribution of the detections within the time window (504, 506, 508).
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
G01S 7/481 - Constructional features, e.g. arrangements of optical elements
The present invention is directed to bifuran copolyesters comprising 2,2′-bifuran-5,5′-dicarboxylic monomer residues. The present invention is further directed to films, coatings or articles comprising said bifuran copolyesters. Also production methods for said bifuran copolyesters are provided. The invention is also directed to a use of a 2,2′-bifuran-5,5′-dicarboxylic monomers in preparing copolyesters having ultraviolet light (UV) blocking properties.
An apparatus for measuring intracranial dynamics comprises the at least one sensing device (100): an electroencephalographic electrode arrangement, which senses direct-current electroencephalographic signals from the brain, an optic measurement arrangement (120), which directs optic radiation toward the brain through the cranium, and receives the optic radiation reflected and/or scattered therefrom, and/or a capacitive sensor arrangement (130), which senses electric potential signals of the head. The apparatus additionally comprises a data processing arrangement (150), which receives electric signals from the at least one sensing device (100), and determine data on at least one of the following dynamics: glymphatic activity, water within the cranium, brain tissue movements, water and/or electrolyte movements and intracranial pressure based on said electric signals from the at least one sensing device (100). The data processing arrangement (150) then outputs at least one piece of the data on the dynamics through a user interface (152).
The ceramic material element includes a main phase of orthorhombic perovskite-structure and a secondary phase due to a heat treatment within 700° C. to 850° C. for a first period followed by a second period within 1140° C. to 1170° C., from a mixture of materials A1, A2, A3, A4 and A5 excluding lead, the materials A1, A2, A3, A4 and A5 having molar ratios R1, R2, R3, R4 and R5, respectively, where the material A1 comprises potassium, the material A2 comprises sodium, the material A3 comprises barium, the material A4 comprises niobium, and the material A5 comprises nickel, and the molar ratio R1 is in a range 0.29-0.32, the molar ratio R2 is in a range 0.20-0.23, the molecular ratio R3 is in a range 0.01-0.02, the molar ratio R4 is in a range 0.54-0.55, and the molar ratio R5 is in a range 0.006-0.011, while a relative ratio of R1/R2 is in the range 1.24-1.52, and a relative ratio of R4/R2 is in the range 2.32-2.62. The ceramic material element converts optical radiation energy and mechanical vibration energy into electric energy.
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
2424244 or said other ceramic, in a ratio of 70 - 90 wt-% the ceramic powder mixture, and 10 - 30 wt-% the aqueous solution. The obtained homogeneous mass is compressed in a mould for 2 - 10 min in room temperature and in a pressure of 100 - 400 MPa. The compressed homogeneous mass is removed from the mould, thereby obtaining electroceramic composite material. Alternatively to the use of the water soluble salt an organometallic precursor compound can be used.
2424244 or said other ceramic, in a ratio of 70 - 90 wt-% solids mixture, and 10 - 30 wt-% aqueous solution. The obtained homogeneous mass is compressed in a mould for 2 - 10 min, in room temperature, in a pressure of 100 - 400 MPa. The compressed mass is removed from the mould, thereby obtaining electroceramic composite material. Alternatively to the use of the water soluble salt an organometallic precursor compound can be used.
Apparatus, method and computer program code for processing computed tomography (CT) scan data is disclosed. The method includes: receiving (202) a real sinogram from a CT scanning of a region of interest of a subject; receiving (204) shape data representing anatomic contours of a body part containing the region of interest of the subject; retrieving (206) a template sinogram from among a plurality of stored template sinograms based on the anatomic contours of the body part; performing (210) an image registration between the real sinogram and the template sinogram to obtain a registered template sinogram; and generating (212) an enlarged sinogram from the real sinogram by adding the non-overlapping parts from the registered template sinogram.
A needle apparatus (10) for taking a sample from inside of an object comprises a stylet (100), which comprises a longitudinal hollow (102). A transmission fiber arrangement (104) and a reception fiber arrangement (112) are on a bottom (126) of a surface (106) of the hollow (102). A first end (108) of the transmission fiber arrangement (104) is at an access tip (110) of the stylet (100). The transmission fiber arrangement (104) guides optical radiation from a second end (120) of the transmission fiber arrangement (104) to the first end (108) and output the optical radiation therefrom. A first end (114) of the reception fiber arrangement (112) is located at the access tip (110). The reception fiber arrangement (112) receives optical radiation from environment of the access tip (110) and guides the optical radiation therefrom to a second end (122) of the reception fiber arrangement (114) and outputs the optical radiation from there.
A range imaging apparatus comprises a semiconductor laser transmitter, a receiver, and a data processing unit, a field-of-illumination of the semiconductor transmitter and a field-of-view of the receiver being overlapping. The receiver comprises single photon avalanche detector elements arranged two-dimensionally and operate in a Geiger mode. The semiconductor laser transmitter generates optical pulses repeatedly, a single optical pulse of the optical pulses being output as an optical beam with one or more stripes, which are parallel, one above another, and separate from each other. Each of the stripes of optical beams, which are reflected from objects within the field-of-view, illuminates a detector element configuration of the single photon avalanche detector elements. The data processing unit performs, synchronously with the optical pulses repeatedly generated, a selection of single photon avalanche detector elements of the detector element configurations in response to a generation of an optical pulse that illuminates one or more detector element configurations with the one or more stripes, and determines values corresponding to time-of-flights of said optical pulse based on electrical signals from the single photon avalanche detector elements of the selection for performing range imaging.
G01S 17/18 - Systems determining position data of a target for measuring distance only using transmission of interrupted, pulse-modulated waves wherein range gates are used
09 - Scientific and electric apparatus and instruments
38 - Telecommunications services
41 - Education, entertainment, sporting and cultural services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Apparatus, instruments and cables for electricity; Magnets, magnetizers and demagnetizers; Measuring, detecting, monitoring and controlling devices; Navigation, guidance, tracking, targeting and map making devices; Optical devices, enhancers and correctors; Recorded content; Scientific and laboratory devices for treatment using electricity; Scientific research and laboratory apparatus, educational apparatus and simulators; Information technology and audio-visual, multimedia and photographic devices; Safety, security, protection and signalling devices. Telecommunication services; Provision and rental of telecommunications facilities and equipment. Education, entertainment and sport services; Publishing, reporting, and writing of texts; Education, entertainment and sports. IT services; Design services; Testing, authentication and quality control; Science and technology services.
42.
ELECTROCERAMIC COMPOSITE MATERIAL AND METHOD OF MANUFACTURING IT
A method of manufacturing ceramic composite material comprises forming a combination of flowable metal oxide precursor (102), which is water-insoluble, and electroceramic powder (104) for covering surfaces of the electroceramic particles (500) with the metal oxide precursor (102), the electroceramic powder (104). A major fraction of the particles (500) has particle diameters within a range 50 µm to 200 µm, and a minor fraction of the particles has diameters smaller than the lower limit of said range, the major fraction having a variety of particle diameters. Then pressure 100 MPa to 500 MPa is applied to said combination, and said combination is exposed, under the pressure, to a heat treatment, which has a maximum temperature within 100°C to 500°C for a predefined period for forming the ceramic composite material.
C04B 35/46 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates
The ceramic material element (106) includes a main phase of orthorhombic perovskite-structure and a secondary phase due to a heat treatment within 700ºC to 850ºC for a first period followed by a second period within 1140ºC to 1170ºC, from a mixture of materials A1, A2, A3, A4 and A5 excluding lead, the materials A1, A2, A3, A4 and A5 having molar ratios R1, R2, R3, R4 and R5, respectively, where the material A1 comprises potassium, the material A2 comprises sodium, the material A3 comprises barium, the material A4 comprises niobium, and the material A5 comprises nickel, and the molar ratio R1 is in a range 0.29-0.32, the molar ratio R2 is in a range 0.20-0.23, the molecular ratio R3 is in a range 0.01-0.02, the molar ratio R4 is in a range 0.54-0.55, and the molar ratio R5 is in a range 0.006-0.011, while a relative ratio of R1/R2 is in the range 1.24-1.52, and a relative ratio of R4/R2 is in the range 2.32-2.62. The ceramic material element (106) converts optical radiation energy and mechanical vibration energy into electric energy.
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
A semiconductor laser source of a transmitter (102) in a range imaging apparatus (100) generates an optical pulse at repeated moments, and outputs spatially separate optical beams towards a target zone (114), such that the semiconductor laser source outputs each of the spatially separate of the optical beams at different moments from each other. A detector (105) of a receiver (104) comprises single-photon sub-detector units, at least two groups of the single-photon sub-detector units have separate field of views towards the target zone (114), and the at least two groups of sub-detector units are associated with different optical beams of the spatially separated optical beams on the basis of the separate field-of-views. A timing unit (106) determines a value corresponding to a time-of-flight of the optical pulse output at each of the repeated moments on the basis of a signal from a group of the sub-detector units associated with an optical beams output at said moment. In an embodiment, the semiconductor laser source comprises a plurality of sub-source units each of which may output a unique optical beam. In an embodiment, the timing unit (106) comprises a selector and a number of time-to-digital converters (108). The receiver selector connects a number of the sub-detector units, which detect the optical pulse (110) and the number of which corresponds to the number of output beams, with the number of the time-to-digital converters (108). In an embodiment, the apparatus (100) comprises an electric power source (192) which supplies a constant electric power to the semiconductor laser source at each of the repeated moments in order to increase brightness of the optical beams. Elongated optical beams may be produced by a laser diode bar (several emitting stripes) and a cylinder lens system or a holographic diffuser. Partially overlapping optical beams may provide illuminated rectangles of the optical beams on the target (112).
The present invention is directed to bifuran copolyesters comprising 2,2'-bifuran-5,5'- dicarboxylic monomer residues. The present invention is further directed to films, coatings or articles comprising said bifuran copolyesters. Also production methods for said bifuran copolyesters are provided. The invention is also directed to a use of a 2,2'-bifuran-5,5'- dicarboxylic monomers in preparing copolyesters having ultraviolet light (UV) blocking properties.
C07D 307/00 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C08G 63/185 - Acids containing aromatic rings containing two or more aromatic rings
46.
Apparatus and method for optically detecting the emissions of a plasma produced in a conductive liquid by means of electrodes with different areas in contact with the liquid
An apparatus comprises: a chamber (100) configured to be filled with electrically conductive liquid (102); a first electrode (104) and a second electrode (106) located within the chamber (100); an optical radiation receiver (126); and an electrically conductive contact area (108) of the first electrode (104) and an electrically conductive contact area (110) of the second electrode (106) are configured to be in contact with the liquid (102) of the chamber (100) wherein the electrically conductive contact area (108) of the first electrode (104) is configured to be smaller than the electrically conductive contact area (110) of the second electrode (106). The first electrode (104) and the second electrode (106) are configured to receive electric energy and output the electric energy to the liquid (102) in order to cause substance of the liquid (102) to emit optical radiation at the electrically conductive contact area (108) of the first electrode (104) on the basis of densification of the electric energy due to the smaller electrically conductive contact area (108) of the first electrode (104). The optical radiation receiver (126) is configured to receive the optical radiation for analysis of the liquid (102).
G01N 21/69 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids
The invention relates to a test arrangement for testing breakage and mechanical properties of rock particles. Test arrangement comprises a support (1, 2) and two counter-rotatable crushing rolls (3, 3') supported on the support (1, 2) and a drive arrangement (Ml, M2) for rotating the crushing rolls (3, 3'). Crushing rolls (3, 3') are facing each other and defining therebetween an input gap (G) for the rock particles, said rolls being arranged to crush rock particles (RP) to smaller daughter particles (DP). Test arrangement comprises a force measurement arrangement (7, 7') for determining the compressive strength of rock particles (RP). Force measurement arrangement (7, 7') being coupled to a processor (PR) comprised by the test arrangement. The processor (PR) being arranged to calculate the breakage force applied to each rock particle (RP) over time. The test arrangement (TA) further comprises an energy measurement arrangement (5, 5') for measuring information relating to energy applied to each rock particle (RP), said energy measurement arrangement (5, 5') being coupled to said processor (PR), said processor (PR) being arranged to calculate energy applied to each rock particle (PR).
An apparatus is configured to operate in a single fundamental transverse mode and the apparatus includes a waveguide layer between an n-doped cladding layer and a p-doped cladding layer. The waveguide layer includes a first waveguide part, and an active layer located between the first waveguide part and the p-doped cladding layer, the active layer being asymmetrically within the waveguide layer closer to the p-doped cladding layer than the n-doped cladding layer. The refractive index of the n-doped cladding layer being equal to or larger than the p-doped cladding layer. A first end of the first waveguide part is adjacent to the n-doped cladding layer. A second end of the first waveguide part is adjacent to a first end of the active layer. A desired donor density is doped in the first waveguide part for controlling the carrier density dependent internal optical loss in the first waveguide part at high injection levels.
H01S 5/20 - Structure or shape of the semiconductor body to guide the optical wave
H01S 5/32 - Structure or shape of the active regionMaterials used for the active region comprising PN junctions, e.g. hetero- or double- hetero-structures
H01S 5/323 - Structure or shape of the active regionMaterials used for the active region comprising PN junctions, e.g. hetero- or double- hetero-structures in AIIIBV compounds, e.g. AlGaAs-laser
A process for manufacturing ceramic-metal composite material, comprises dissolving ceramic powder into water to obtain an aqueous solution of ceramic; mixing metal powder having a multimodal particle size where largest particle size is one fourth of the minimum dimension of a device, with the aqueous solution of ceramic to obtain a powder containing ceramic precipitated on the surface of metal particles; mixing the powder containing ceramic precipitated on the surface of the metal particles, with ceramic powder having a particle size below 50μιτι, to obtain a powder mixture; adding saturated aqueous solution of ceramic to the powder mixture to obtain an aqueous composition containing ceramic and metal; compressing the aqueous composition to form a disc of ceramic-metal composite material containing ceramic and metal; and removing water from the ceramic-metal composite material; wherein ceramic content of the disc is 10 vol-% to 35 vol-%. Alternatively, ceramic-ceramic composite material may be manufactured.
C22C 32/00 - Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
C22C 1/051 - Making hard metals based on borides, carbides, nitrides, oxides or silicidesPreparation of the powder mixture used as the starting material therefor
B22F 1/052 - Metallic powder characterised by the size or surface area of the particles characterised by a mixture of particles of different sizes or by the particle size distribution
4 in a mouldable form, optionally mixing the ceramic thermal insulation material with at least one additive, covering an electronic component with the material, shaping the material covering the electronic component into a desired form, and drying the desired form at a temperature of from 20° C. to 120° C.
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
Portable respiratory airway obstruction measuring apparatus (100). Apparatus includes an inertial measurement unit (102) configured to measure (502) a respiration-related movement (160), and a microphone (104) configured to measure (504) through an ambient air (190) an airflow (162) of a mouth (154) of the subject (150) caused by the breathing, and means (110) for obtaining (506) an ambient barometric pressure (170). Apparatus includes processing unit (106) configured to analyze (508) the motion data (168) and the airflow data (166) in order to measure a time delay (122) between the respiration-related movement (160) and the airflow (162), to define (510) a cycle length (124) of the breathing based on the motion data (168) and/or the airflow data (166), and to compute (512) a specific airway resistance/conductance (126) of the subject (150) based on the time delay (122), the ambient barometric pressure (170), and the cycle length (124).
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
Joint analysis probe (100). The probe (100) includes a frame (102). The probe (100) also includes a microphone (106) embedded into the frame (102) and configured to measure sounds (108) from a joint (162) of a subject (160) in a non- contact manner. The probe (100) also includes a raised rim (104) around the microphone (106) configured and positioned to be in contact with the subject (160) when the microphone (106) measures the sounds (108) from the joint (162), whereby the raised rim (104) attenuates an ambient noise (110) captured by the microphone (106).
A semiconductor laser source of a transmitter (102) in a range imaging apparatus (100) generates an optical pulse at repeated moments, and outputs spatially separate optical beams towards a target zone (114), such that the semiconductor laser source outputs each of the spatially separate of the optical beams at different moments from each other. A detector (105) of a receiver (104) comprises single-photon sub-detector units, at least two groups of the single-photon sub-detector units have separate field of views towards the target zone (114), and the at least two groups of sub-detector units are associated with different optical beams of the spatially separated optical beams on the basis of the separate field-of-views. A timing unit (106) determines a value corresponding to a time-of-flight of the optical pulse output at each of the repeated moments on the basis of a signal from a group of the sub-detector units associated with an optical beams output at said moment. In an embodiment, the semiconductor laser source comprises a plurality of sub-source units each of which may output a unique optical beam. In an embodiment, the timing unit (106) comprises a selector and a number of time-to-digital converters (108). The receiver selector connects a number of the sub-detector units, which detect the optical pulse (110) and the number of which corresponds to the number of output beams, with the number of the time-to-digital converters (108). In an embodiment, the apparatus (100) comprises an electric power source (192) which supplies a constant electric power to the semiconductor laser source at each of the repeated moments in order to increase brightness of the optical beams. Elongated optical beams may be produced by a laser diode bar (several emitting stripes) and a cylinder lens system or a holographic diffuser. Partially overlapping optical beams may provide illuminated rectangles of the optical beams on the target (112).
An optical time-of-flight distance measuring device comprises a transmitter and a receiver. The transmitter comprises a semiconductor laser for outputting optical pulses of controllably variable temporal widths. The semiconductor laser operates in an enhanced switching regime for the optical pulses of a minimum generable temporal width of the laser. The receiver comprises a matrix of single photon avalanche detector elements of a Geiger mode, a receiver controller, and one or more time-to-digital converters. The single photon avalanche detector elements detect optical pulses reflected from the target to the matrix, and each of the single photon avalanche detector element outputs an electric signal in response to each detection. A number of the time-to-digital converters is smaller than a number of the single photon avalanche detector elements of the matrix. The receiver controller connects at least two of the single photon avalanche detector elements with different time-to-digital converters. The time-to-digital converters connected with the single photon avalanche detector elements provide timings of detected optical pulses on the basis of each output electrical signal for determination of information associated with a distance of the target.
The present invention discloses a method and a system for super-frame realignment to enable inter-wireless network communications. The networks can be Wireless Body Area Networks. In the present invention, it is checked whether the inter-beacon interval (IBI) of the data channel of the own network is of shorter or longer duration than the IBI of the data channel of the target network, and if the IBI of the data channel of the own network does not have exactly the same duration as the IBI of the data channel of the target network, the own network allocates its own inactive (304) and/or active periods so that an integer multiple of its forthcoming IBI will correspond to the IBI of the target network, or the forth-coming IBI of the own network will correspond to an integer multiple of the IBI of the target network.
The present invention discloses a method and a system for discovering a neighbouring network by an already operational network. The networks comprise a control channel (CCH) and a data channel (DCH), both comprising a beacon to be transmitted, respectively. The channels are predetermined and beacon formats of theft control channels (CCH) are known, and an inter-beacon-interval of the data channel (DCH) of the already operational network comprises an active period followed by an inactive period. The present invention is characterized in that the temporal lengths of the inactive periods are changed in the data channel (DCH) of the already operational network. Furthermore, the method is configured to search for a beacon of a predetermined control channel (CCH) of a neighbouring network during subsequent inactive periods of the already operational network.
The present invention provides a method for preparing RNA probes useful for exome sequencing protocols or alternatively a method for the preparation of RNA probes which can be used for the separation of circular such as organelle DNA from nuclear genome.
36 - Financial, insurance and real estate services
39 - Transport, packaging, storage and travel services
41 - Education, entertainment, sporting and cultural services
43 - Food and drink services, temporary accommodation
Goods & Services
Clothing; Shoes; Hats. Business assistance, management and administrative services; Business analysis, research and information services; Event marketing; Organisation of events for commercial and advertising purposes; Organization of events, exhibitions, fairs and shows for commercial, promotional and advertising purposes; Export promotion services; Advertising, marketing and promotional services; Advertising, marketing and promotional consultancy, advisory and assistance services; Distribution of advertising, marketing and promotional material; Advertising in the field of tourism and travel; Import and export services; Commercial intermediation services; Accountancy, book keeping and auditing; Administrative data processing; Auctioneering services; Business consultancy and advisory services; Clerical services; Collection and systematization of business data; Commercial information and advice for consumers [consumer advice shop]; Human resources management and recruitment services; Loyalty, incentive and bonus program services; Marketing studies; Product demonstrations and product display services; Provision of advertising space, time and media; Public relations services; Provision of commercial information; Procurement of contracts for the purchase and sale of goods and services; Retail services relating to food; Retail services relating to home textiles; Retail services in relation to computer software; Retail services in relation to games; Retail services in relation to luggage; Retail services in relation to jewellery; Retail services in relation to fabrics; Retail services in relation to educational supplies; Retail services in relation to bags; Retail services in relation to printed matter; Wholesale services in relation to printed matter; Retail services in relation to works of art; Presentation of goods on communication media, for retail purposes; Retail services in relation to information technology equipment; Retail services in relation to recorded content; Retail services in relation to cups and glasses; Retail services connected with the sale of clothing and clothing accessories; Wholesale services in relation to clothing; Retail services in relation to shoes; Wholesale services in relation to shoes; Retail services relating to sporting goods; Retail services in relation to tableware; Retail services in relation to toys; Retail services in relation to headgear; Wholesale services in relation to headgear; Retail services in relation to umbrellas; Wholesale services in relation to tableware; Wholesale services in relation to bags; Wholesale services in relation to umbrellas; Wholesale services in relation to educational supplies; Wholesale services in relation to sporting equipment; Wholesale services in relation to toys; Wholesale services in relation to computer software; Wholesale services in relation to games; Wholesale services in relation to sporting articles; Wholesale ordering services; Online retail services relating to cosmetics. Fundraising and financial sponsorship; Venture capital (Services for the finding of -); Venture capital funding services to emerging and start-up companies; Venture capital services; Financial planning services; Financial appraisal services; Financial and monetary services, and banking; Financial information, data, advice and consultancy services; Investment services; Surety services; Real estate services. Computerised information services relating to travel; Travel consultancy; Providing information about travel, via the Internet; Travel guide and travel information services; Travel and passenger transportation; Travel reservation and booking services; Computerised reservation services for travel; Travel consultancy and information services; Provision of tourist travel information; Providing information relating to travel and transport, via electronic means; Sightseeing, tour guide and excursion services; Transportation and storage; Navigation (positioning, and route and course plotting); Mail delivery and courier services; Parking and vehicle storage, mooring; Rental of means of transportation; Distribution by pipeline and cable; Rescue, recovery, towing and salvage services. Education, entertainment and sport services; Publishing and reporting; Organisation of conferences, exhibitions and competitions; Arranging of seminars relating to business; Conducting of seminars and congresses; Arranging of workshops and seminars; Organising events for entertainment purposes; Organising events for cultural purposes; Education and instruction services; Arranging of training courses; Audio, video and multimedia production, and photography; Multimedia publishing; Training courses in strategic planning relating to advertising, promotion, marketing and business; Arranging and conducting of educational events; Ticketing and event booking services; Entertainment booking services; Ticket reservation and booking services for cultural events; Conducting of instructional, educational and training courses for young people and adults; Publication of directories relating to travel; Tutoring; Health and fitness training; Sports and fitness services; Consultancy relating to physical fitness training; Translation and interpretation; Library services. Hotels, hostels and boarding houses, holiday and tourist accommodation; Services for providing food and drink; Restaurant services; Provision of information relating to restaurants; Making reservations and bookings for restaurants and meals; Consultancy services in the field of food and drink catering; Cookery advice; Rental of furniture, linens and table settings.
59.
METHOD OF MANUFACTURING OPTICAL SEMICONDUCTOR APPARATUS AND THE APPARATUS
An apparatus (100) is configured to operate in a single fundamental transverse mode and the apparatus (100) comprises a waveguide layer (102) between an n-doped cladding layer (112) and a p-doped cladding layer (104). The waveguide layer (102) includes an first waveguide part (200), and an active layer (108) located between the first waveguide part (200) and the p-doped cladding layer (104), the active layer (108) being asymmetrically within the waveguide layer (102) closer to the p-doped cladding layer (104) than the n-doped cladding layer (112). The refractive index of the n-doped cladding layer (112) being equal to or larger than the p-doped cladding layer (104). A first end (202) of the first waveguide part (200) is adjacent to the n-doped cladding layer (112). A second end (204) of the first waveguide part (200) is adjacent to a first end (206) of the active layer (108). A desired donor density is doped in the first waveguide part (200) for controlling the carrier density dependent internal optical loss in the first waveguide part (200) at high injection levels.
A process for manufacturing ceramic-metal composite material, comprises dissolving ceramic powder into water to obtain an aqueous solution of ceramic; mixing metal powder having a multimodal particle size where largest particle size is one fourth of the minimum dimension of a device, with the aqueous solution of ceramic to obtain a powder containing ceramic precipitated on the surface of metal particles; mixing the powder containing ceramic precipitated on the surface of the metal particles, with ceramic powder having a particle size below 50 μιτι, to obtain a powder mixture; adding saturated aqueous solution of ceramic to the powder mixture to obtain an aqueous composition containing ceramic and metal; compressing the aqueous composition to form a disc of ceramic-metal composite material containing ceramic and metal; and removing water from the ceramic-metal composite material; wherein ceramic content of the disc is 10 vol-% to 35 vol-%. Alternatively, ceramic-ceramic composite material may be manufactured.
C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C04B 35/01 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides
C04B 35/26 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on ferrites
C04B 35/46 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates
C04B 35/468 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates based on titanates based on alkaline earth metal titanates based on barium titanates
C04B 35/491 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates containing also titanium oxide or titanates based on lead zirconates and lead titanates
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
24244 in a mouldable form, optionally mixing the ceramic thermal insulation material (1) with at least one additive, covering an electronic component (3) with the material, shaping the material covering the electronic component (3) into a desired form, and drying the desired form at a temperature of from 20°C to 120°C.
C04B 35/495 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on vanadium, niobium, tantalum, molybdenum or tungsten oxides or solid solutions thereof with other oxides, e.g. vanadates, niobates, tantalates, molybdates or tungstates
The invention relates to a measurement system (100) for establishing a forecast for structural icing of a mechanical structure. The measurement comprises a digital in-line holography apparatus (1) comprising a monochromatic light source (12) and matrix detector (22) to record diffraction images (25a) due to cloud droplets (25, 26, 27). A computer (3) or the server (4) is configured to calculate sizes and number of the cloud droplets (25, 26, 27) by utilizing the recorded diffraction images (25a) and for calculating a liquid water content and median volume diameter of the cloud droplets detected in the open measurement space. The computer or server (4) combines the liquid water content and median volume diameter calculation results with meteorological measurement data, speed of the moving mechanical structure (51) and 3D -model information of the mechanical structure (51) for making a forecast about structural icing speed of the moving mechanical structure (51).
An arrangement (100) for knee diagnostics comprising a measurement apparatus (110) attachable to a leg, and a processing apparatus (140). The measurement apparatus (110) comprises three frames (112, 116, 130) with various sensors: audio sensors (124, 126), thermal sensors (120, 122), and inertial sensors (114, 132). The processing apparatus (140) is caused to: analyze (202) the medial sound and the lateral sound to produce an assessment (204) of a joint friction of the knee; analyze (206) the thigh inertial data and the lower leg inertial data to produce an assessment (208) of a malalignment of the knee; analyze (210) the medial temperature and the lateral temperature to produce an assessment (212) of an inflammation of the knee; and compile (214) an assessment (216) of a condition of the knee (306) based on said assessments (204, 208, 212).
An optical time-of-flight distance measuring device comprises a transmitter (102) and a receiver (105). The transmitter (102) comprises a semiconductor laser (200) for outputting optical pulses (110, 110') of controllably variable temporal widths. The semiconductor laser (200) operates in an enhanced switching regime for the optical pulses of a minimum generable temporal width of the laser (200). The receiver (105) comprises a matrix (300) of single photon avalanche detector elements (310 to 326) of a Geiger mode, a receiver controller (302), and one or more time-to-digital converters (330). The single photon avalanche detector elements (310 to 326) detect optical pulses reflected from the target (112) to the matrix (300), and each of the single photon avalanche detector element (310 to 326) outputs an electric signal in response to each detection. A number of the time-to-digital converters (330) is smaller than a number of the single photon avalanche detector elements (310 to 326) of the matrix (300). The receiver controller (302) connects at least two of the single photon avalanche detector elements (310 to 326) with different time-to-digital converters (330). The time-to-digital converters (330) connected with the single photon avalanche detector elements (310 to 326) provide timings of detected optical pulses on the basis of each output electrical signal for determination of information associated with a distance of the target (112).
APPARATUS AND METHOD FOR OPTICALLY DETECTING THE EMISSIONS OF A PLASMA PRODUCED IN A CONDUCTIVE LIQUID BY MEANS OF ELECTRODES WITH DIFFERENT AREAS IN CONTACT WITH THE LIQUID
An apparatus comprises: a chamber (100) configured to be filled with electrically conductive liquid (102); a first electrode (104) and a second electrode (106) located within the chamber (100); an optical radiation receiver (126); and an electrically conductive contact area (108) of the first electrode (104) and an electrically conductive contact area (110) of the second electrode (106) are configured to be in contact with the liquid (102) of the chamber (100) wherein the electrically conductive contact area (108) of the first electrode (104) is configured to be smaller than the electrically conductive contact area (110) of the second electrode (106). The first electrode (104) and the second electrode (106) are configured to receive electric energy and output the electric energy to the liquid (102) in order to cause substance of the liquid (102) to emit optical radiation at the electrically conductive contact area (108) of the first electrode (104) on the basis of densification of the electric energy due to the smaller electrically conductive contact area (108) of the first electrode (104). The optical radiation receiver (126) is configured to receive the optical radiation for analysis of the liquid (102).
G01N 21/67 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence using electric arcs or discharges
G01N 21/69 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids
The present invention relates to medicaments based on oligomeric forms of 3- hydroxybutyrate, particularly 3-hydroxybutyrate methyl ester dimer (1) and trimer (2), especially for use in treating, preventing and/or inhibiting development of a disorder or condition related to oxidative stress. The present invention relates also to the use of these molecules as antioxidants, and to a method for increasing proliferation and viability of plant cells in the aid of molecules 1and 2.
A61K 31/22 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
C07C 69/675 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A receiver unit includes at least one single photon avalanche detector element of a Geiger mode and a time-to-digital converter circuit. Each single photon avalanche detector element is enabled to detect a photon in at least one time-gated window, and each single photon avalanche detector element is configured to output an electric pulse in response to detection of a photon of optical radiation within the at least one time-gated window. The time-to-digital converter circuit provides timing data associated with said electric pulse for determination of a distance of a target on the basis of the timing data provided by the time-to-digital converter circuit.
Improvements on latency are achieved for highest priority messaging and channel utilization in a time-slotted access channel structure. New superframe structures are presented where scheduled, but unused access slots can be utilized by secondary nodes. The messaging is accomplished by defining user priorities for nodes and the nodes sensing an ongoing transmission in the network. The time slotted channel access structure has at least one access phase which is divided into access slots. In the beginning of the access phase the nodes sense if a highest priority transmission exist and if not, another node with a lower user priority may initiate transmission.
An apparatus comprises a semiconductor single-photon avalanche detector, and a counter. The detector performs detections of photons of optical radiation caused by an optical excitation pulse to the object. The counter measures timing of each detection made in the detector with respect to the excitation pulse causing the detected photons, and performs at least one of the following: forming a number of Raman detections, forming a number of fluorescence detections. Forming the number of the Raman detections is performed by eliminating an estimate of a number of fluorescence photons in the measurement. Forming the number of the fluorescence detections is performed by eliminating an estimate of a number of Raman photons in the measurement. The estimates are formed in a predetermined manner from the number and timing of the detections.
A vertical cavity surface emitting laser (VCSEL) configured to operate in a gain switching regime includes a cavity that is terminated by reflectors at both ends for enabling a standing wave of optical radiation therebetween. The cavity comprises at least one quantum well, each of the quantum wells located at a position where a value of a standing wave factor for each quantum well is between zero and one, 0<ξ<1.
H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
71.
ON-DEMAND IDENTITY ATTRIBUTE VERIFICATION AND CERTIFICATION FOR SERVICES
There is provided an apparatus caused to store identification data of a plurality of clients in the memory; cause reception of information indicating at least one identifier of a device corresponding to a client requesting access to a service; verify the identity of the client device on the basis of the received at least one identifier; detect whether or not the identified device is authorized to communicate with the apparatus on the basis of first predetermined criteria; upon detecting that the device is authorized, cause reception of information indicating at least one identifier of the client from the identified device; verify the at least one identifier of the client on the basis of the received at least one identifier and the stored identification data; and determine, on demand, whether or not to issue a certificate indicating the verifications on the basis of second predetermined criteria in order to enable the client to apply the certificate in accessing the service.
There is provided a method comprising: applying ultra wideband, UWB, in communication of data between a transmitter and a receiver, wherein the UWB applies a physical layer symbol structure suitable for the application of a pulse position modulation; and causing, within a symbol time interval, an indication of a distinct in-formation unit in each of a first burst time interval and a second burst time interval, wherein the first burst time interval is intended for representing a bit value to a certain user in the pulse position modulation, and a second burst time interval is intended for representing an opposite bit value to the same user in the pulse position modulation, thereby forming a pair of burst time intervals.
There is provided a method, comprising: applying ultra wideband, UWB, in communication of data between a transmitter and a receiver, wherein the UWB applies a physical layer symbol structure suitable for the application of a pulse position modulation; determining at least one modulation method to be applied in the communication of user data between the transmitter and the receiver, wherein the determined at least one modulation method does not comprise the pulse position modulation; adding information related to the determined at least one modulation method in a header of a physical layer frame structure; applying the pulse position modulation in the transmission of the header of the physical layer frame structure to the receiver; and applying the determined at least one modulation method, instead of the pulse position modulation, in the transmission of user data to the receiver.
This invention concerns a method of improving penetration of compositions to dentin, enamel, dental pulp or cement and dental compositions for restoration or decoration of teeth, for use in pulp medication comprising, for root canal disinfection and/or obturation and for desensitizing. This invention also concerns uses of DMSO for improving the bond strength of dental composition and in preparing dental compositions. Further the invention concerns a new method of treating teeth so that penetration of components is increased.
Bone drill (1OO) for medical operations. In the bone drill, there is an elongated drill component (101), which is manufactured from a superelastic material, and an essentially straight drill- component shield (103), which is hollow. According to the invention, at the end of the drill- component shield there is a guide arrangement (102) for selecting for the drill component a turn angle (α; β) relative to the drill-component shield, and once the drill component has run through the guide part, the superelastic properties of its material return it to its original shape and the drill component is then (101) is a position, in which it can be used to drill in the direction of the turn angle (α; β).
The present invention relates to a method for producing natively folded disulfide bond containing proteins in a prokaryotic host. The method comprises that in the cytoplasm of a prokaryotic cell is expressed protein(s) of interest that naturally contain disulfide bonds and naturally occurring or inverted transmembrane en- zyme, wherein the cysteines of the active site(s) are naturally or after genetic en- gineering located towards the prokaryotic cytoplasm. The enzyme is selected from the group of VKOR, inverted VKOR (iVKOR) and inverted Dsb B (iDsb B). In the prokaryotic cell is also expressed cytoplasmic DsbA or a corresponding pro- tein being capable of providing electrons to the active site(s) of VKOR, iVKOR or iDsbB. The invention relates also to a prokaryotic host cell and a vector system for producing natively folded disulfide bond containing proteins.
The present invention provides a photocatalyst material comprising nitrogen-doped Ti02 nanofibers decorated with nanoparticles of high work function material or with p-type semiconductors. The present invention also provides a method for producing said photocatalyst material and applications related to said material.
There is provided an apparatus (300) for measuring a distance to a target (312), comprising: a transmitter (302) configured to transmit an optical pulse (310) towards the target (312), a receiver channel (304) configured to receive the optical pulse (310) reflected from the target (312), and a processor (306) configured to measure a time intervaf between the transmission and detection of the optical pulse (310) at a predefined amplitude threshold level (11OA, 110B), to determine a time domain parameter from the detected optical pulse (310) at one or more amplitude threshold levels (110A, 110B), to convert the time domain parameter value into a correction value by a conversion model; to correct a timing error in the measured time interval by the correction value, and to convert the error-corrected time interval into a distance to the target (312).
The present invention relates to a method for functionalizing a film, a functionalized film, a method for producing a sensory film comprising contacting the functionalized film, a sensory film and a biosensor comprising a sensory film and means for detection wherein the film has layers of polymer, sol-gel, dialdehyde, and at least one sensory component. Such functionalized film is usable e.g. when there is a need for linking various components to a surface in gentle conditions. The sensory films or the biosensors are usable in all kinds of diagnostics.
A single pulse semiconductor laser operating in the gain-switching regime comprises a plane asymmetric waveguide and an active layer in the waveguide, the ratio of a thickness of the active layer to an optical confinement factor of the laser being extremely large, larger than about 5 μm, for example.
H01S 5/20 - Structure or shape of the semiconductor body to guide the optical wave
H01S 5/062 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes
H01S 5/32 - Structure or shape of the active regionMaterials used for the active region comprising PN junctions, e.g. hetero- or double- hetero-structures
An apparatus comprises a plurality of detecting elements and a summer. Each detecting element receives and detects different bands of spectrum of Raman radiation formed in response to at least one optical excitation pulse directed to the object. The detecting elements and/or the summer receives a command to enable registration of detections in the detecting elements and a command to disable the registration during or after the Raman radiation. The summer registers separately the detections of the Raman radiation in at least two detecting elements for presenting data on the object on the basis of the detections.
Method for utilizing kaoline or metakaoline created as a result of the thermal processing of kaoline in a water purification process in which the water to be purified comprises impurities at least from one group that belongs to the group: organic impurities, inorganic impurities, harmful metals, harmful metallic compounds and in which case kaoline or metakaoline is added to the water to be purified. Kaoline or metakaoline is added to the water to be purified as particles either exclusively or together with intermediate agents, such as the regulating chemicals of pH or with a coagulating chemical which water is located into an reservoir used as a processing space, into a flow-through reservoir (1 ) or to a sufficient pipe extension in which all the movement speed of water is slowed down by increasing the cross-sectional area of the processing space to be essentially greater than the cross-sectional area of the inlet stream pipe (2), the removal of the mentioned particles from the reservoir (1) along the water to be removed is prohibited in which case the particles cause a precipitation impact due to their chosen particle size, under 0,1 mm, due to which impurities, precipitates and particles become settled down at the bottom of the processing space.
The present invention relates to a method for producing a protein of interest containing one or more disulfide bonds in its native state. The method comprises that a prokaryotic host cell is genetically engineered to express the protein of interest and a sulfhydryl oxidase in the cytoplasm of the host cell. The protein of interest is formed in a soluble form and contains disulfide bonds due to the presence of the sulfhydryl oxidase in the cytoplasm of said host cell. The present invention relates also to a prokaryotic host cell and a vector system for producing a protein of interest containing natively folded disulfide bonds.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
An apparatus, a method, and a computer program for predicting a risk to a cardiac death are presented. The apparatus (100) comprises a processor (116) configured to calculate morphoiogica! parameter values (values of total cosine R-to-T, values of QRS complex loop asymmetry, values of T wave loop dispersion, values of QRS complex and T wave principal component analysis, values of an angle between a main QRS complex loop vector and a main T wave loop vector) of QRS complex and T wave from a sample period within electrocardiography data recorded from a subject; to calculate heart rate values from the sample period; to form an association result between the change of the morphological parameter values and change of the heart rate values; and to predict a risk to a cardiac death of the subject on the basis of the way the association result fulfils a predetermined condition.
A61B 5/0452 - Detecting specific parameters of the electrocardiograph cycle
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
85.
A CARBON FIBER MULTICHANNEL ELECTRODE FOR MEASURING ELECTRICAL AND CHEMICAL ACTIVITY IN BIOLOGICAL TISSUE AND A PROCESS FOR MAKING THE ELECTRODE
The invention relates to a multichannel electrode used in measuring electrical and chemical activity in biological tissue and a method for manufacturing the multi-channel electrode. For manufacturing the multichannel electrode a carbon fiber and a conductor are first attached together. Electrodes are electrically insulated from each other by directly applying insulation on their surface, or by inserting them in capillary tubes made of glass or plastic. Insulated single electrodes are then integrated into a bunch. If capillary tubes are used as insulator, the bunch is drawn to a fine tip by using heat. In both variations, distance between the tips of the electrodes is 5-50 micrometers. Electro active area at the tip can be precisely adjusted using electrochemical etching and partial insulation with suitable dielectric such as electrophoretic deposition paint. The tips may additionally be coated with suitable material such as carbon nanotubes, conductive polymer, metals of different kind, or synthetic or biological molecules.
The present invention relates to methods and products for the treatment of any disorder or condition, which is associated with abnormal amount of non-collagenous protein, or abnormal oligomerization or dysfunction of non-collagenous protein, such as adiponectin in the blood circulation and/or tissue of a patient. The treatment comprises that functional form of the non-collagenous protein is adjusted in the blood circulation and/or tissue of the patient substantially to the level it is in the blood circulation and/or tissue of a healthy person, by using lysyl hydroxylase and/or glycosyl-transferase activities of LH3 or other lysyl hydroxylase to modify the non-collagenous protein to HMW or other functional form.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
There is provided an apparatus (300) for measuring a distance to a target (312), comprising: a transmitter (302) configured to transmit an optical pulse (310) towards the target (312), a receiver channel (304) configured to receive the optical pulse (310) reflected from the target (312), and a processor (306) configured to measure a time intervaf between the transmission and detection of the optical pulse (310) at a predefined amplitude threshold level (11OA, 110B), to determine a time domain parameter from the detected optical pulse (310) at one or more amplitude threshold levels (110A, 110B), to convert the time domain parameter value into a correction value by a conversion model; to correct a timing error in the measured time interval by the correction value, and to convert the error- corrected time interval into a distance to the target (312).
A single pulse semiconductor laser operating in the gain- switching regime comprises a plane asymmetric waveguide and an active layer in the waveguide, the ratio of a thickness of the active layer to an optical confinement factor of the laser being extremely large, larger than about 5μm, for example.
H01S 5/062 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes
H01S 5/323 - Structure or shape of the active regionMaterials used for the active region comprising PN junctions, e.g. hetero- or double- hetero-structures in AIIIBV compounds, e.g. AlGaAs-laser
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
The present invention relates to products and methods, which can be used for preventing tumour growth. Lysylhydroxylase enzyme, LH3 or LH or fragments thereof being essentially deficient of glycosyltransferase activity, or nucleotide sequences encoding said enzymes or fragments thereof, can be used to prevent tumour growth.
The present invention relates to new products, and methods, which can be used in regulating cell and tissue growth. In particular, the present invention relates to new products, and methods, which can be used for improving cell or tissue growth. According to the method, glycosyltransferase activity in cell or tissue culture or growth system is increased, said glycosyltransferase activity being the glycosyltransferase activity of lysyl hydroxylase 3 (LH3) or LH enzyme capable of glycosylating hydroxylysine residues. By means of the i cell or tissue growth in cell or tissue cultures or in human or animal body can be regulated and cell growth of, for example, nerve cells, can be improved.
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
A measuring arrangement comprising a radiation source a detector for detecting radiation emitted by the radiation source and to provide a detection level indicator indicating the quantity of the detected radiation, a measuring element configured to bend in relation to a force affecting the measuring element, a screening element attached to or consisting of the measuring element movable in the radiation at least partly hindering the radiation of entering the detector and a moving unit configured to change the relative position of the screening element between the radiation source and the detector until the detector level indicator reaches a high-sensitivity measurement area of the detection level indicator.
G01L 1/25 - Measuring force or stress, in general using wave or particle radiation, e.g. X-rays, neutrons
G01D 5/32 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light
G01B 11/02 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness
G01B 21/30 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring roughness or irregularity of surfaces
The present invention provides a method for controlling the growth of microbes grown in a medium to high cell-densities by the fed-batch technology, wherein a two-phase system, having a liquid phase (cultivation medium) and a solid or gel phase, the solid or gel phase provides a source of substrate-delivering polymer which is turned by an enzyme in a controlled way into a growth-limiting substrate or pH adjusting agent. The present invention also provides a method for restricting the synthesis of growth-limiting metabolites and preventing oxygen-depletion in microbial cell cultures.
The invention relates to a method and an arrangement for performing triggering and for determining a triggering moment. In the solution, a unipolar electrical pulse of a detector (106, 118) is converted between the detector (106, 118) and a first amplifier (108, 120) succeeding the detector into at least one bipolar electrical oscillation. The bipolar electrical oscillation is amplified with at least one amplifier (108, 120) and triggering is performed at a zero level between the extreme values of the bipolar electrical oscillation. In addition, a triggering moment is determined, at which the amplified bipolar electrical oscillation crosses the zero level between its extreme values.
