A method performed by one or more computers may include receiving patient specific data; producing a set of predictive features that characterize the patient specific data; performing one or more simulations of a body of the patient based on the patient specific data to produce one or more simulation results that are predictive of effects of denervation procedures being performed to the body of the patient; processing the set of predictive features using a predictive machine learning model to generate a predicted output characterizing predicted effects of one or more denervation procedures on the body of the patient; and providing data characterizing the predicted effects of the one or more denervation procedures for display on a user device.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
3.
CATHETER-BASED HIGH INTENSITY THERAPEUTIC ULTRASOUND (HITU) TRANSDUCER WITH FLEX CIRCUIT
A catheter assembly comprising: a high intensity therapeutic ultrasound (HITU) transducer shaped as a cylindrical shell that includes an inner surface defining a chamber, an outer shell for launching ultrasound waves outward, a proximal rim and a distal rim between the inner surface and the outer shell; a post structure located in the chamber and electrically connected to the inner surface of the cylindrical shell; and a flex circuit comprising at least one signal pad electrically connected the outer shell of the HITU transducer and at least one ground pad electrically connected to the post structure.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
An implant deployment device comprises an elongate delivery tube and a handle at a proximal end of the delivery tube. The handle comprises a control element such as a thumbwheel that is movable relative to a housing of the handle. This, in turn, moves a deployment component of the delivery tube, such as an outer sheath, to an extent sufficient to deploy an implant from the delivery tube. The handle also comprises a detent element that acts separately and simultaneously on the control element and on the deployment component The detent element is movable relative to the housing from an initial locked position, in which movements of the control element and the deployment component are blocked, to an unlocked position enabled for use, in which deploying movements of the control element and the deployment component are permitted.
A system for treating at least one nerve in target tissue in proximity to an AV fistula of a patient having an epidermis may include a ablation element configured to emit ablation energy to the at least one nerve in proximity to an AV fistula; a generator electrically coupled to the transducer, wherein the generator transmits electrical energy to the transducer; and a spacer connected to the ablation element, wherein at least part of the spacer is configured to contact the surface of the epidermis in proximity to the nerves surrounding the AV fistula, and thereby space the ablation element a particular distance from the surface of the epidermis; where the ablation energy is sufficient to anesthetize at least one of the nerves in the target tissue.
Tubular stents are placed in series in a blood vessel, each stent having a body portion that extends along a majority of a length of the stent adjoining an end portion that extends along a minority of the length of the stent. The body portion and the end portion of at least one of the stents are pre-formed with diameters that differ from each other. The end portion of the first stent is a complementary inter-engaging fit with the end portion of the second stent, either receiving or received by the end portion of the second stent, for example in telescopic male/female relation.
A61F 2/852 - Two or more distinct overlapping stents
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
8.
Display screen or portion thereof with transitional graphical user interface
Described herein are systems and methods for tracking a target tissue during therapy delivery. A system for identifying an anatomical structure and tracking the motion of the anatomical structure using imaging before and during delivery of a therapy to a patient includes an imaging module and a therapy module. In some cases, the imaging module is configured to identify a region of the anatomical structure in an image, and the therapy module is configured to deliver the therapy to a target tissue. A method for imaging during delivery of a therapy includes acquiring an image, identifying a region of an anatomical structure, tracking the region of the anatomical structure, integrating the tracking, generating a unique template library, determining if a pre-existing template matches the results or if the results should be updated as a new template, and delivering the therapy to the target tissue.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/225 - Surgical instruments, devices or methods for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06T 7/44 - Analysis of texture based on statistical description of texture using image operators, e.g. filters, edge density metrics or local histograms
A device and method of treating cancerous tissue from a blood vessel, such as a blood vessel proximate a pancreas having pancreatic cancer. The device includes a disruption apparatus and a fixation element fixing a position of the disruption apparatus within the blood vessel. The disruption apparatus is configured to disrupt cancer cells of the pancreatic cancer from within the blood vessel. The method includes delivering the device through the blood vessel to a position adjacent to the cancerous tissue, and disrupting the cancerous tissue by delivering heat or energy to the cancer. Other embodiments are described and claimed.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A tissue treatment system may comprise a catheter including a distal portion on which is located an ultrasound transducer, where at least the distal portion of the catheter is insertable into a segment of a body lumen having a diameter within a range of diameters having a lower subrange and an upper subrange; an excitation source that provides energy to the ultrasound transducer; and a controller that controls the excitation source to cause the ultrasound transducer to emit at least a first amount of acoustic energy and a second amount of acoustic energy greater than the first amount of acoustic energy; where the controller controls the excitation source to cause the ultrasound transducer to emit the first amount of acoustic energy into a body lumen having a diameter within the lower subrange, and the second amount of acoustic energy into a body lumen having a diameter within the upper subrange.
A tissue treatment system may comprise a catheter including a distal portion on which is located an ultrasound transducer, where at least the distal portion of the catheter is insertable into a segment of a body lumen having a diameter within a range of diameters having a lower subrange and an upper subrange; an excitation source that provides energy to the ultrasound transducer; and a controller that controls the excitation source to cause the ultrasound transducer to emit at least a first amount of acoustic energy and a second amount of acoustic energy greater than the first amount of acoustic energy; where the controller controls the excitation source to cause the ultrasound transducer to emit the first amount of acoustic energy into a body lumen having a diameter within the lower subrange, and the second amount of acoustic energy into a body lumen having a diameter within the upper subrange.
A tissue treatment catheter includes a catheter shaft having a guidewire lumen and a guidewire port extending through an outer shaft wall between the guidewire lumen and a surrounding environment. The tissue treatment catheter includes a port brace disposed in the guidewire lumen. The port brace includes a proximal brace section in the guidewire lumen proximal to the guidewire port. The port brace includes a distal brace section in the guidewire lumen distal to the guidewire port. The proximal brace section is stiffer than the distal brace section. Other embodiments are also described and claimed.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A tissue treatment catheter includes a catheter shaft having a guidewire lumen and a guidewire port extending through an outer shaft wall between the guidewire lumen and a surrounding environment. The tissue treatment catheter includes a port brace disposed in the guidewire lumen. The port brace includes a proximal brace section in the guidewire lumen proximal to the guidewire port. The port brace includes a distal brace section in the guidewire lumen distal to the guidewire port. The proximal brace section is stiffer than the distal brace section. Other embodiments are also described and claimed.
A tissue treatment catheter includes a catheter shaft, an ultrasound transducer, and a balloon. The catheter shaft has a fluid lumen. The ultrasound transducer is mounted on the catheter shaft. The balloon is mounted on the catheter shaft. The balloon surrounds the ultrasound transducer and has an interior in fluid communication with the fluid lumen. The balloon includes a balloon shoulder extending from a balloon neck to a balloon body. The balloon shoulder has a weeping section between the balloon neck and a weeping perimeter. The balloon shoulder has a non-weeping section between the weeping perimeter and the balloon body. The weeping section includes one or more holes and the non-weeping section is solid. Other embodiments are described and claimed.
A61B 17/00 - Surgical instruments, devices or methods
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
An exemplary method of treating a mammalian patient, with a kidney, a vasculature including a main renal artery and at least one distal branch of the main renal artery, the at least one distal branch having a vessel wall, and at least one renal nerve associated with the at least one distal branch, may include inserting a catheter into the vasculature of the patient, the catheter having a distal end; advancing the distal end of the catheter through the vasculature into the at least one distal branch; and applying radiofrequency energy to the at least one distal branch to heat the vessel wall of the at least one distal branch and ablate the at least one renal nerve associated with the at least one distal branch in which the distal end of the catheter is positioned.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
A method of controlling injection of a contrast medium by a contrast injector includes delivering, by a fluid transfer unit of a tissue treatment system, inflation fluid at an inflation pressure to a balloon. The method includes injecting, by a contrast injector of the tissue treatment system, contrast medium at an injection pressure into a vessel containing the balloon. The method includes determining one or more of the inflation pressure or the injection pressure. The method includes stopping, based on one or more of the inflation pressure or the injection pressure, injection of the contrast medium. Other embodiments are also described and claimed.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A catheter for use in analyzing neural activity of nerves that surround a biological lumen includes a handle and a shaft extending from the handle. The shaft configured to be inserted into the biological lumen. The selectively inflatable balloon is located on the shaft. The distal electrode and the proximal electrode are longitudinally spaced apart from one another on the shaft. Each of the distal electrode and the proximal electrode is configured to be selectively transitioned between a non-intussuscepted position and an intussuscepted position.
National Institute of Advanced Industrial Science and Technology (Japan)
Otsuka Medical Devices Co., Ltd. (Japan)
Inventor
Takagi, Ryo
Inui, Koji
Abstract
A system for evaluating a treatment device capable of radiating ultrasound for cauterizing human tissue, the system including: simulated tissue having a property that hue changes according to temperature in a particular temperature-sensitive area and simulating temperature change of human tissue at time of the human tissue receiving the ultrasound from the treatment device, the simulated tissue having an insertion hole where the treatment device can be arranged; a light source radiating planar light from the whole circumference, the light source being arranged surrounding the simulated tissue; an image taking device taking cross-sectional color images of light irradiation surfaces of the simulated tissue; and movement mechanisms causing the light source and the image taking device to relatively move in a photographing axis direction of the image taking device relative to the simulated tissue; and a movement mechanism control/information processing unit controlling the movement mechanism.
G01K 11/12 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in colour, translucency or reflectance
A method of delivering ultrasonic energy toward a vessel wall of a pulmonary artery tree is provided. A catheter of a tissue treatment system is advanced to a treatment zone within the pulmonary artery tree. The tissue treatment system includes an expandable member and an ultrasonic transducer. The treatment zone has the vessel wall distal to a main pulmonary artery of the pulmonary artery tree. The expandable member is deployed against the vessel wall, and ultrasonic energy is delivered from the ultrasound transducer toward the vessel wall. Other embodiments are also described and claimed.
A tissue treatment catheter includes a catheter shaft having a fluid lumen in fluid communication with an interior of a balloon, and a guidewire lumen. The balloon is mounted on the catheter shaft and contains an ultrasound transducer. An isolation tube extends through the ultrasound transducer and into the guidewire lumen. A proximal tube end of the isolation tube is between a distal shaft end of the catheter shaft and a guidewire port of the catheter shaft. Other embodiments are also described and claimed.
A fluid control device for an ultrasound-based treatment system having at least one motor having a motor shaft extending from an axis of the motor. The at least one camshaft is operatively coupled to the motor shaft in rotational communication with the motor shaft. The at least one actuator in communication with the at least one camshaft. When the motor shaft is operating, the motor shaft causes the at least one camshaft to rotate, thereby moving the at least one actuator between a first position and a second position through a fluid channel of a cartridge manifold. Other embodiments are also described and claimed.
A catheter comprising a catheter shaft and a self-rotating ultrasound transducer positioned along a longitudinal axis on a distal region of the catheter shaft, the self-rotating ultrasound transducer having a shape wherein the self-rotating ultrasound transducer is configured to self- rotate around the longitudinal axis when an acoustic radiation force generates a net momentum from reactive forces from a surrounding environment that has a net non-zero torque around a rotation axis of the self-rotating ultrasound transducer.
A tissue treatment catheter includes a catheter shaft having a fluid lumen in fluid communication with an interior of a balloon, and a guidewire lumen. The balloon is mounted on the catheter shaft and contains an ultrasound transducer. An isolation tube extends through the ultrasound transducer and into the guidewire lumen. A proximal tube end of the isolation tube is between a distal shaft end of the catheter shaft and a guidewire port of the catheter shaft. Other embodiments are also described and claimed.
A stent comprises a longitudinal series of circumferential tubular segments that are separated by, and alternate with, gaps along the length of the stent between opposed end segments of the series. Each segment of the series comprises struts that are disposed in a circumferentially extending waveform arrangement. Successive segments of the series are interconnected by connectors that bridge the respective gaps. Segments of the series disposed between the end segments comprise at least one anchor segment that is pre-formed with a radially enlarged configuration relative to at least one interconnected adjacent body segment of lesser radius. In use, the anchor segments engage a surrounding vessel wall to resist migration of the stent, assisted by serrations defined by the struts of the waveform arrangement. An anchor segment is connected to a body segment by connectors extending between facing troughs of the waveform arrangements of those successive segments.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/848 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
31.
DEVICES, METHODS AND SYSTEMS FOR RENAL DENERVATION
A technique of renal denervation comprising methods and devices for generating one or more bubbles to at least partially fragment a calcification of a calcified region of a renal artery and for ablating one or more nerves about, within, or surrounding the calcified region of the renal artery after the calcification has been at least partially fragmented. Other embodiments are described and claimed.
A61B 18/24 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor with a catheter
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
32.
DEVICES, METHODS AND SYSTEMS FOR RENAL DENERVATION
A technique of renal denervation comprising methods and devices for generating one or more bubbles to at least partially fragment a calcification of a calcified region of a renal artery and for ablating one or more nerves about, within, or surrounding the calcified region of the renal artery after the calcification has been at least partially fragmented. Other embodiments are described and claimed.
The present disclosure includes a system for use in the treatment of cancer, the system comprising
an extracorporeal circulation device comprising a blood circuit and a blood pump to collect and return blood of a subject, and
a light irradiation device to irradiate the blood circuit with light,
wherein a photosensitive substance is administered to the subject prior to blood collection, or added to blood collected from the subject prior to light irradiation,
the blood collected from the subject and irradiated with light is returned to the subject, and
the light has an irradiation energy density of 2.5 to 300 J/cm2.
A catheter includes a catheter shaft deliverable through a radial access approach. The catheter shaft has a fluid lumen. A balloon is mounted on the catheter shaft and has an interior in fluid communication with the fluid lumen. An ultrasound transducer is in the interior. A flow control device has an inlet port to received fluid passing through the interior from the fluid lumen. The flow control device is configured to vent the fluid to a surrounding environment when the fluid has a predetermined pressure. Other embodiments are also described and claimed.
An apparatus comprising an ultrasound transducer configured for emitting ultrasound is provided. The ultrasound transducer comprises a hollow piezoelectric transducer body having a longitudinal axis and a radially inner surface, a tubular backing support member extending longitudinally through the piezoelectric transducer body and having a radially outer surface, a chamber defined between the radially inner surface of the piezoelectric transducer body and the radially outer surface of the tubular backing support member and between a first end and an opposite second end in an axial direction, wherein said ends are each formed by a conductive part and a gas-tight sealing layer of metal solder material in contact with the surface of the conductive part, which is opposite to the chamber.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
36.
AIR-BACKED TRANSDUCERS FOR ULTRASOUND DENERVATION AND METHODS AND SYSTEMS THAT USE AIR-BACKED TRANSDUCERS
An apparatus comprising an ultrasound transducer configured for emitting ultrasound is provided. The ultrasound transducer comprises a hollow piezoelectric transducer body having a longitudinal axis and a radially inner surface, a tubular backing support member extending longitudinally through the piezoelectric transducer body and having a radially outer surface, a chamber defined between the radially inner surface of the piezoelectric transducer body and the radially outer surface of the tubular backing support member and between a first end and an opposite second end in an axial direction, wherein said ends are each formed by a conductive part and a gas-tight sealing layer of metal solder material in contact with the surface of the conductive part, which is opposite to the chamber.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
37.
DRUG-ELUTING STENT INCLUDING CRYSTALLINE CILOSTAZOL
Provided is a stent comprising: a stent skeleton; and a deposition layer containing a plurality of layers deposited on the stent skeleton; each layer of the deposition layer comprising crystalline cilostazol, at least one of the plurality of layers comprising a bioabsorbable polymer.
A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
38.
METHODS AND SYSTEMS FOR MEASURING RENAL NEURAL ELECTRICAL ACTIVITY BY ELECTRICALLY STIMULATING IN ABDOMINAL AORTA AND SENSING EVOKED NEURAL ELECTRICAL RESONSE IN RENAL ARTERY
Techniques for evaluating neural electrical activity of renal nerves of a patient for which a renal denervation procedure has been or is going to be performed are described. A distal portion of a guide catheter is inserted through an abdominal aorta so the distal portion is positioned adjacent to a renal artery ostium, or in a proximal portion of the renal artery. The guide catheter is used to insert a distal portion of a mapping catheter within the renal artery, and a stimulation electrode positioned in the abdominal aorta (within a specified distance of the renal artery ostium) is used to deliver electrical stimulation pulse(s) to evoke a neural electrical response from renal nerves in tissue surrounding the renal artery. A sense electrode positioned in the renal artery, downstream from the stimulation electrode, is used to sense the neural electrical activity evoked in response to the stimulation pulse(s).
A61B 5/388 - Nerve conduction study, e.g. detecting action potential of peripheral nerves
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
39.
METHODS, DEVICES AND SYSTEMS THAT USE ONE OR MORE TRANSDUCERS TO HEAT NERVES TO EVOKE NEURAL RESPONSE WITHOUT DENERVATING NERVES, AS WELL AS TO DENERVATE NERVES
Certain methods and systems described herein use a transducer used to produce ablation energy (aka denervation energy) to also evoke a neural response before and/or after denervation energy is delivered. Rather than the neural response being invoked in response to electrical stimulus, it is invoked in response to the transducer (e.g., RF, microwave, or ultrasound transducer) being used to sufficiently heat the nerves in tissue surrounding a biological lumen to an extent that a neural response is evoked without denervating the nerves. That is, the transducer used for performing ablation (aka denervation) is also used to evoke a neural response prior to (and/or after) ablation is performed, by using the transducer to sufficiently heat the nerves in the tissue surrounding the biological lumen to an extent that a neural response is evoked without denervating the nerves. This can reduce the catheter production complexity and costs. Other embodiments are also disclosed.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A tissue treatment system includes a catheter and a generator. The catheter is configured to be introduced into a blood vessel. The catheter includes an ultrasound transducer disposed at a distal end portion of the catheter to emit an unfocused ultrasound energy to treat a target tissue from the blood vessel. The generator is configured to drive the ultrasound transducer with a frequency. The generator is configured to control the frequency to change during the treatment of the target tissue. Other embodiments are also described and claimed.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
41.
SYSTEMS AND METHODS FOR PERFORMING A DENERVATION PROCEDURE AND DETERMINING THE EFFICACY THEREOF
Described herein are systems and methods for performing a denervation procedure and determining an efficacy thereof. Such a system can include an excitation source, a controller, and a catheter with element(s) for delivering first ablation therapy from a first longitudinal location along a biological lumen and delivering second ablation therapy from a second longitudinal location longitudinally spaced apart from the first longitudinal location. A sensing subsystem of the system senses neural activity from a third longitudinal location along the biological lumen, to determine the efficacy of at least one of the first or second ablation therapies.
Tissue treatment systems and methods are disclosed. A tissue treatment system comprises a signal generator, a sensing circuit coupleable to electrode(s) of a catheter, and a controller. The sensing circuit senses neural activity of nerves within tissue surrounding a biological lumen using electrode(s) of the catheter inserted into the biological lumen. The controller determines one or more characteristics of the sensed neural activity of the nerves within the tissue surrounding the biological lumen. The controller also selects one or more denervation parameters based on the one or more characteristics of the sensed neural activity, and controls the signal generator to generate, using the selected one or more denervation parameters, signals for performing a denervation procedure intended to denervate at least some of the nerves for which the neural activity was sensed.
Tissue treatment systems and methods are disclosed. A tissue treatment system comprises a signal generator, a sensing circuit coupleable to electrode(s) of a catheter, and a controller. The sensing circuit senses neural activity of nerves within tissue surrounding a biological lumen using electrode(s) of the catheter inserted into the biological lumen. The controller determines one or more characteristics of the sensed neural activity of the nerves within the tissue surrounding the biological lumen. The controller also selects one or more denervation parameters based on the one or more characteristics of the sensed neural activity, and controls the signal generator to generate, using the selected one or more denervation parameters, signals for performing a denervation procedure intended to denervate at least some of the nerves for which the neural activity was sensed.
A61B 18/12 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
Described herein are systems and methods for performing a denervation procedure and determining an efficacy thereof. Such a system can include an excitation source, a controller, and a catheter with element(s) for delivering first ablation therapy from a first longitudinal location along a biological lumen and delivering second ablation therapy from a second longitudinal location longitudinally spaced apart from the first longitudinal location. A sensing subsystem of the system senses neural activity from a third longitudinal location along the biological lumen, to determine the efficacy of at least one of the first or second ablation therapies.
Described herein are catheters for use in analyzing neural activity of nerves that surround a biological lumen. Such a catheter comprises a handle including a first, second, and third actuators, and a shaft extending from the handle and including proximal and distal electrodes that are selectively deployable. The first actuator is configured to selectively deploy the proximal electrode in response to the first actuator being manually maneuvered. The second actuator is configured to selectively deploy the distal electrode in response to the second actuator being manually maneuvered. The third actuator is configured to selectively adjust a longitudinal distance between the proximal and distal electrodes in response to the third actuator being manually maneuvered.
A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The parameter curve includes inflections that correspond to changes in the fluid parameter. Based on the inflections, the system can determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.
A catheter (102), comprising: a catheter shaft (212) having a fluid channel (420), an ultrasound transducer (214) and a compliant balloon (108) mounted on the catheter shaft (212) and having an interior (504) in fluid communication with the fluid channel (420) and containing the ultrasound transducer (214). The compliant balloon (108) includes a balloon wall (502) having a working section (1600) radially surrounding the ultrasound transducer (214), a proximal shoulder (510B) proximal to the working section (1600), and a distal shoulder (510A) distal to the working section (1600). The balloon wall (502) is thicker at the proximal shoulder (510B) and the distal shoulder (510A) than at the working section (1600).
A tissue treatment system (100) configured to determine a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen, is described. The tissue treatment system (100) fills a balloon (112) with a fluid (213) when the balloon (112) is within a body lumen. A fluid parameter of the fluid (213) is detected over a period of time. A parameter curve (200¤) of the fluid parameter is determined. The parameter curve (2004) includes the fluid parameter versus an independent variable over the period of time. The parameter curve (2004) includes inflections (2006) that correspond to changes in the fluid parameter. Based on the inflections (2006), the system (100) can determine the body lumen size or the neuromodulation parameter.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A catheter comprises a catheter shaft having a fluid channel, an ultrasound transducer and a compliant balloon mounted on the catheter shaft and having an interior in fluid communication with the fluid channel and containing the ultrasound transducer. The compliant balloon includes a balloon wall having a working section radially surrounding the ultrasound transducer. The working section has a predetermined straightness when the working section has a first diameter and when the working section has a second diameter that is at least 2 mm greater than the first diameter. Other embodiments are also described and claimed.
A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The system compares the parameter curve of the fluid parameter to a reference curve and, based on the comparison, determine the body lumen size or the neuromodulation parameter. Other embodiments are also described and claimed.
A catheter has at least a first transducer located in an interior of at least a first balloon, the first transducer configured to be operated at an operational frequency. The first transducer transmits an acoustic signal that provides a first acoustic field with multiple lobes along a longitudinal axis of the first transducer, each of the lobes has a spatial intensity maximum in a spatial intensity distribution of the first acoustic field, the spatial intensity distribution being at a surface of the first balloon and parallel to a surface of the first transducer, the spatial intensity distribution of the first acoustic field having one or more reduced spatial acoustic intensity locations where the spatial intensity of the acoustic field of the first transducer is 50% or less of a value of one of the spatial intensity maxima of the first transducer, each of the reduced spatial acoustic intensity locations being between the spatial intensity maxima for lobes that are adjacent to one another along the longitudinal axis of the first transducer, and each of the reduced spatial acoustic intensity locations being on the surface of the first balloon between the spatial intensity maxima that are adjacent to one another along the longitudinal axis of the first transducer. The catheter further comprises at least a first electrode configured to transmit an electromagnetic signal, the first electrode being positioned on the first balloon at one of the reduced spatial acoustic intensity location of the first transducer.
A treatment system (100) includes a generator (202) and a fluid transfer cartridge (204). The fluid transfer cartridge (204) includes a cartridge shell (306) defining a cartridge cavity (402) between a front face (402) and a rear face (404). The front face (402) includes an opening (406), and the cartridge cavity (402) is visibly exposed through the opening (406). The fluid transfer cartridge (204) includes a syringe barrel (408) disposed within the cartridge cavity (402), and a handle (307) that extends from the front face (404) over the opening (406). The syringe barrel (408) can be visibly exposed on a side (410) of the handle (307).
A61F 7/12 - Devices for heating or cooling internal body cavities
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A tissue treatment system and method of using the tissue treatment system determines a size of a body lumen, or a neuromodulation parameter corresponding to the size of the body lumen. The tissue treatment system fills a balloon with a fluid when the balloon is within a body lumen. A fluid parameter of the fluid is detected over a period of time. A parameter curve of the fluid parameter is determined. The parameter curve includes the fluid parameter versus an independent variable over the period of time. The system compares the parameter curve of the fluid parameter to a reference curve and, based on the comparison, determine the body lumen size or the neuromodulation parameter.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A catheter (10) has at least a first transducer (34) located in an interior of at least a first balloon (14), the first transducer (34) configured to be operated at an operational frequency. The first transducer (34) transmits an acoustic signal that provides a first acoustic field with multiple lobes along a longitudinal axis of the first transducer (34), each of the lobes has a spatial intensity maximum in a spatial intensity distribution of the first acoustic field, the spatial intensity distribution being at a surface of the first balloon (14) and parallel to a surface of the first transducer (34), the spatial intensity distribution of the first acoustic field having one or more reduced spatial acoustic intensity locations where the spatial intensity of the acoustic field of the first transducer (34) is 50% or less of a value of one of the spatial intensity maxima of the first transducer (34), each of the reduced spatial acoustic intensity locations being between the spatial intensity maxima for lobes that are adjacent to one another along the longitudinal axis of the first transducer (34), and each of the reduced spatial acoustic intensity locations being on the surface of the first balloon (14) between the spatial intensity maxima that are adjacent to one another along the longitudinal axis of the first transducer (34). The catheter (10) further comprises at least a first electrode (76) configured to transmit an electromagnetic signal, the first electrode (76) being positioned on the first balloon (14) at one of the reduced spatial acoustic intensity location of the first transducer (34).
A treatment system includes a generator and a fluid transfer cartridge. The fluid transfer cartridge includes a cartridge shell defining a cartridge cavity between a front face and a rear face. The front face includes an opening, and the cartridge cavity is visibly exposed through the opening. The fluid transfer cartridge includes a syringe barrel disposed within the cartridge cavity, and a handle that extends from the front face over the opening. The syringe barrel can be visibly exposed on a side of the handle. Other embodiments are also described and claimed.
A treatment system includes a generator and a fluid transfer cartridge. The fluid transfer cartridge includes a cartridge shell having a cartridge cavity. The cartridge cavity is between a front face and a rear face. A syringe barrel is disposed within the cartridge cavity, and has a syringe cavity. The fluid transfer cartridge includes a cartridge manifold in the cartridge cavity. The cartridge manifold includes a fluid transfer plate having a front fluid channel in a front plate surface, and a rear fluid channel in a rear plate surface. The cartridge manifold includes a fluid port extending through the fluid transfer plate from the front fluid channel to the rear fluid channel. The front fluid channel, the rear fluid channel, and the fluid port are in fluid communication with the syringe cavity. Other embodiments are also described and claimed.
A tissue treatment catheter and system include a catheter shaft sized and shaped for delivery through a radial artery to a blood vessel of a patient. The catheter shaft has several lumens, including a guidewire lumen, a cable lumen, and one or more fluid lumens. A stiffening web extends from the guidewire lumen and is thicker than an outer wall of the catheter shaft. The tissue treatment catheter and system include an ultrasound transducer, a balloon surrounding the ultrasound transducer, and a single electrical cable electrically connected to the ultrasound transducer to deliver sufficient electrical energy during sonication to the transducer such that the transducer thermally induces modulation of neural fibers surrounding the blood vessel sufficient to improve a measurable physiological parameter corresponding to a diagnosed condition of the patient. Other embodiments are described and claimed.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (Japan)
OTSUKA MEDICAL DEVICES CO., LTD. (Japan)
Inventor
Takagi, Ryo
Inui, Koji
Abstract
Provided is a system for evaluating a treatment device capable of projecting ultrasonic waves for cauterizing human body tissue, wherein the occurrence of focus deviation can be suppressed and a clear image can be acquired. The system for evaluating a treatment device is capable of projecting ultrasonic waves for cauterizing human body tissue, the system comprising: a simulated tissue that has a property in which a hue changes due to the temperature in a specific temperature-sensitive region, and that simulates a temperature change of a human body tissue upon receiving ultrasonic waves from a treatment device, the simulated tissue having an insertion hole into which the treatment device can be disposed; a light source that is disposed so as to surround the simulated tissue and that projects planar light from the entire circumference thereof; an imaging device that captures a cross-section color image of a surface of the simulated tissue irradiated with the light; a movement mechanism that relatively moves the light source and the imaging device relative to the simulated tissue in an imaging axis direction of the imaging device; a color/temperature conversion table for calculating a temperature from the hue of the image of the simulated tissue; and a movement mechanism control/information processing unit that controls the movement mechanism so that the light source and the imaging device move in a state in which the distance between the light irradiation surface and the imaging device is kept constant, and that further uses the color/temperature conversion table to acquire a temperature distribution of the simulated tissue from the hue at each position of the captured image of the simulated tissue. The treatment device is disposed in the insertion hole of the simulated tissue.
G01K 11/12 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in colour, translucency or reflectance
G01K 15/00 - Testing or calibrating of thermometers
59.
THERAPEUTIC ULTRASOUND TISSUE TREATMENT SYSTEMS, APPARATUSES, AND METHODS
Described herein are acoustic-based tissue treatment systems, apparatuses, and methods for use therewith. Certain such apparatuses comprise a catheter sized and shaped for delivery through a radial artery including a catheter shaft having distal and proximal ends, a plurality of lumens extending longitudinally through the catheter shaft between the distal and proximal ends thereof, and an ultrasound transducer distally positioned relative to the distal end of the catheter shaft. A balloon may surround the ultrasound transducer and at least one of the plurality of lumens may be configured to provide a cooling fluid to the balloon at a pressure and flow rate sufficient to protect non-target tissue in the blood vessel wall from thermal injury. In certain embodiments, the apparatus also includes a single electrical cable extending through one of the lumens and including first conductor(s) coupled to the first electrode of the ultrasound transducer, and second conductor(s) coupled to the second electrode of the ultrasound transducer. The single electrical cable may be configured to deliver sufficient electrical energy during sonication to the transducer such that the transducer thermally induces modulation of neural fibers surrounding the blood vessel sufficient to improve a measurable physiological parameter corresponding to a diagnosed condition of the patient.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
Disclosed herein are ultrasound transducers that are selectively insulated to thereby enable the transducers to be exposed to an electrically conductive fluid without causing a short circuit between electrodes of the transducers. Such a transducer includes a piezoelectric transducer body having a first surface and a second surface that are spaced apart from one another and do not intersect with one another. The ultrasound transducer also includes a first electrode disposed on the first surface, a second electrode disposed on the second surface, and an electrical insulator covering only one of first and second electrodes and configured to inhibit electrical conduction between the first electrode and the second electrode when the ultrasound transducer is placed within an electrically conductive fluid. Also disclosed are apparatuses and systems that include such a transducer. Related methods are also disclosed herein.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
Disclosed herein are ultrasound transducers that are selectively insulated to thereby enable the transducers to be exposed to an electrically conductive fluid without causing a short circuit between electrodes of the transducers. Such a transducer includes a piezoelectric transducer body having a first surface and a second surface that are spaced apart from one another and do not intersect with one another. The ultrasound transducer also includes a first electrode disposed on the first surface, a second electrode disposed on the second surface, and an electrical insulator covering only one of first and second electrodes and configured to inhibit electrical conduction between the first electrode and the second electrode when the ultrasound transducer is placed within an electrically conductive fluid. Also disclosed are apparatuses and systems that include such a transducer. Related methods are also disclosed herein.
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
Provided is a stent comprising: a stent skeleton; and a deposition layer containing a plurality of layers deposited on the stent skeleton; each layer of the deposition layer comprising crystalline cilostazol, at least one of the plurality of layers comprising a bioabsorbable polymer, wherein elution of not more than 5% by mass of the crystalline cilostazol occurs by 24 hours after the stent is brought into contact in vitro at 37° C. with an elution medium of a phosphate-buffered sodium chloride solution containing 0.25% by mass of sodium lauryl sulfate.
Provided is a wire-equipped stent having further improved ease of handling. A wire-equipped stent 10 includes a wire 12, a stent 11 connected to a distal side D1 end portion of the wire 12, and a highly smooth portion provided at or adjacent to a distal side D1 portion of the wire 12. The wire-equipped stent 10 is adapted for insertion into and use in a catheter including a structure including a mesh coil and a spiral coil overlapping each other.
The present disclosure includes a system for treating cancer, the system comprising: an extracorporeal circulation device that is for collecting and returning the blood of a subject, and that includes a blood circuit and a blood pump; and a light irradiation device that is for irradiating the blood circuit with light. A photosensitive substance is administered to the subject before blood collection or is added, before light irradiation, to blood collected from the subject. The blood that has been collected from the subject and has been irradiated with light is returned to the subject. The irradiation energy density of the light is 2.5-300 J/cm2.
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 31/197 - Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
The stent has an expansive force 0.05 N/mm or less per unit length when it has a diameter equal to the lower limit diameter of the target blood vessel and is measured under the following conditions. A radial force testing system manufactured by Blockwise Engineering LLC is used as a tester. The test conditions include a temperature of 37° C.±2° C. in the chamber of the tester; a stent diameter of 0.5 mm for start of test, and a rate of increase of diameter of 0.5 mm/s in the tester. The test method includes radially compressing the stent disposed in the chamber; recording an expansive force while gradually increasing the diameter of the chamber at the rate of increase of diameter; and dividing the expansive force by the effective length of the stent to calculate an expansive force per unit length.
A61F 2/76 - Means for assembling, fitting, or testing prostheses, e.g. for measuring or balancing
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
The present disclosure involves a system, etc., said system being for treating cancer and comprising an extracorporeal circulation device that comprises a blood circuit and a blood pump for collecting and returning blood of a subject and a light irradiation device for irradiating light on the blood circuit, wherein a light sensitive substance is either administered to the subject prior to the blood collection or added, prior to the light irradiation, to the blood collected from the subject, and the blood having been collected from the subject and irradiated with light is returned to the subject to thereby enhance an immune response to cancer cells in the subject.
Described herein are systems and methods for tracking a target tissue during therapy delivery. A system for identifying an anatomical structure and tracking the motion of the anatomical structure using imaging before and during delivery of a therapy to a patient includes an imaging module and a therapy module. In some cases, the imaging module is configured to identify a region of the anatomical structure in an image, and the therapy module is configured to deliver the therapy to a target tissue. A method for imaging during delivery of a therapy includes acquiring an image, identifying a region of an anatomical structure, tracking the region of the anatomical structure, integrating the tracking, generating a unique template library, determining if a pre-existing template matches the results or if the results should be updated as a new template, and delivering the therapy to the target tissue.
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06T 7/44 - Analysis of texture based on statistical description of texture using image operators, e.g. filters, edge density metrics or local histograms
A61B 17/00 - Surgical instruments, devices or methods
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A stent according to the invention includes: a strut extending in a predetermined direction; a first protrusion provided on the strut, the first protrusion being substantially L-shaped and extending in a direction away from the strut and in a direction toward a distal side in the predetermined direction; a second protrusion that is provided on the strut and located distal to the first protrusion, the second protrusion being substantially L-shaped, extending in a direction away from the strut and in a direction toward a proximal side in the predetermined direction, and having a tip spaced apart from a tip of the first protrusion; and an opaque member being substantially tubular and highly opaque to radiation, the opaque member having two end portions in which the first and second protrusions are inserted, respectively.
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
Provided are a stent that has guaranteed high bonding strength between a strut and an opaque member and has high reliability to prevent the opaque member from coming off in a luminal structure; and a method for inspecting such a stent. A stent according to the invention includes: a leg portion provided with protrusions; and an opaque member that is provided along the longitudinal direction of the protrusions to cover the protrusions, the opaque member being highly opaque to radiation, the opaque member having: sparse areas with a spacing ratio higher than a predetermined spacing ratio; and a dense area with a spacing ratio lower than the predetermined spacing ratio, the opaque member being fixed on or to the protrusions with adhesives in the sparse areas.
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
A stent system according to the present invention is for use in retrieving a blood clot from the brain region and includes a wire; a first stent connected to a distal portion of the wire; a first outer sheath that covers and is fixed to a portion of the wire proximal to the first stent; and a second stent disposed on a portion of the wire proximal to the first stent, in which the second stent is configured to be movable toward or away from the first stent.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A stent that comprises a stent skeleton and deposited layers consisting of a plurality of layers deposited on the stent skeleton, wherein each layer in the deposited layers contains crystalline cilostazol and at least one of the plurality of layers contains a bioabsorbable polymer. From this stent, 5 mass% or less of the aforesaid crystalline cilostazol is eluted 24 hours after contacting the stent with an elution medium at 37°C in vitro, said elution medium being a phosphate-buffered sodium chloride solution containing 0.25 mass% of sodium lauryl sulfate.
A61L 31/12 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A stent includes wavy-line pattern bodies having a wavy-line pattern and arranged side-by-side in an axial direction LD, and coiled elements arranged between the wavy-line pattern bodies adjacent and extending in a spiral manner around an axis. All apices on opposite sides of the wavy-line pattern of the wavy-line pattern bodies that are adjacent are connected by way of the coiled element. When viewing in a radial direction RD, a circular direction CD of the wavy-line pattern bodies is inclined with respect to the radial direction RD, and a winding direction of one of the coiled elements located at one side in the axial direction LD with respect to the wavy-line pattern bodies and a winding direction of one other of the coiled elements located at the other side in the axial direction LD are opposite.
A61F 2/92 - Stents in the form of a rolled-up sheet expanding after insertion into the vessel
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/04 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
75.
Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
Described herein are systems and methods for tracking a target tissue during therapy delivery. A system for identifying an anatomical structure and tracking the motion of the anatomical structure using imaging before and during delivery of a therapy to a patient includes an imaging module and a therapy module. In some cases, the imaging module is configured to identify a region of the anatomical structure in an image, and the therapy module is configured to deliver the therapy to a target tissue. A method for imaging during delivery of a therapy includes acquiring an image, identifying a region of an anatomical structure, tracking the region of the anatomical structure, integrating the tracking, generating a unique template library, determining if a pre-existing template matches the results or if the results should be updated as a new template, and delivering the therapy to the target tissue.
A61B 17/225 - Surgical instruments, devices or methods for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
G06T 7/44 - Analysis of texture based on statistical description of texture using image operators, e.g. filters, edge density metrics or local histograms
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 17/00 - Surgical instruments, devices or methods
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
An ultrasound apparatus is described for externally treating kidney stone in human body. The apparatus has one or more ultrasound imaging transducers, a therapeutic ultrasound transducer, and a processing unit. Optimized delivering of ultrasound energy to the kidney stone from the therapeutic ultrasound transducer is based on real-time tracked state (e.g., position, movement shape, size, or combination thereof) of the kidney stone. The ultrasound imaging transducer(s) is configured to image the stone during the application of the therapy treatment. An optimization algorithm is implemented to control the therapeutic ultrasound transducer to apply different force vectors to the region of the stone. The effect of the vectors in the differing directions with respect to the stone may be detected and input to the optimization algorithm, which optimizes the therapy by adjusting one or more of the vectors. Therefore, less ultrasound energy may be delivered to break the kidney stone, and may reduce the possibility of damaging the surrounding tissues of the kidney stone.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
77.
ULTRASOUND URINE VOLUME METER AND URINE VOLUME MEASUREMENT METHOD USING SAME
[Problem] To be able to measure urine volume in the bladder and temporal changes thereof with high precision in a necessary period that corresponds to the urine volume and to limit electric power consumption. [Solution] Ultrasonic waves are transmitted toward the bladder of a person being measured with a specified measurement period. Reflected waves from the bladder wall surfaces are received and the urine volume inside the bladder is calculated for each measurement period on the basis of said reflected waves. When the calculated urine volume inside the bladder is at least a pre-alarm urine volume, the measurement period is shortened.
The present invention easily positions an ultrasound probe with high precision at a mounting position / angle suitable for measuring urine volume. The ultrasound urine volume meter comprises: a mode-selecting section (22a) that makes it possible to select either a measurement mode for measuring urine volume with an ultrasound probe (10) mounted at a specified measurement position on the abdomen of a person being measured or a positioning mode for moving the ultrasound probe (10) to multiple temporary measurement positions on the abdomen while measuring urine volume to determine a measurement position suitable for mounting the ultrasound probe (10) in the measurement mode; and an index value storage section (23a) for storing the maximum value among the urine volumes at the multiple temporary measurement positions measured while the positioning mode is selected as the maximum sensitivity value. The maximum sensitivity value and/or permissible sensitivity value is displayed on a graph on a display unit (27) as positioning index values (31, 32) for positioning the ultrasound probe (10).
Provided are: a urine volume measurement system and urine volume management data-preparing method capable of preparing urine volume management data such as a urination diary easily and accurately with little burden to the person being measured such as a patient; and a urine volume management data-preparing terminal. The urine volume measurement system comprises: a calculation unit (24) for calculating accumulated urine volume in the bladder for every measurement period on the basis of ultrasonic waves reflected from the bladder wall surfaces; an urge to urinate-inputting section (22a) for inputting an urge to urinate signal; a measured data storage section (23a) for storing accumulated urine volumes calculated by the calculation unit (24), the measurement times thereof, and the times of urge to urinate corresponding to the times of input of an urge to urinate signal; a management data-preparing section (24c) for lining up the accumulated urine data including the accumulated urine volumes and measurement times therefor, urge to urinate data including said times of the urge to urinate, and voiding data including voided urine volumes calculated on the basis of the accumulated urine data and the voiding times therefor in a time series to prepare urine volume management data; and a management data storage section (23b) for storing said urine volume management data.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
80.
ULTRASONIC URINE VOLUME MEASURING INSTRUMENT, AND URINE VOLUME MANAGEMENT DATA GENERATING AND DISPLAYING METHOD USING ULTRASONIC URINE VOLUME MEASURING INSTRUMENT
To provide an ultrasonic urine volume measuring instrument that can highly accurately measure urine volume of a measurement subject and that is convenient for the measurement subject. There are provided a mode selector 22a capable of selecting one of a measurement mode of measuring urine volume while an ultrasound probe 10 is placed at a certain measurement position on the stomach of a measurement subject, and a positioning mode of measuring urine volume while moving the ultrasound probe 10 to a plurality of tentative measurement positions on the stomach in order to determine the measurement position suitable for placing the ultrasound probe 10 in the measurement mode; and an index value memory 23a that stores a maximum value among urine volumes at the plurality of tentative measurement positions, calculated by the arithmetic unit 24, while the positioning mode is being selected, and/or an allowance value determined on the basis of the maximum value. The maximum value and/or the allowance value is displayed, on a graph on a display unit 27, as a positioning index value for positioning the ultrasound probe 10.
A stent includes: wavy-line pattern bodies having a wavy-line pattern and arranged side-by-side in an axial direction; and coiled elements arranged between the wavy-line pattern bodies adjacent and extending in a spiral manner around an axis, in which all apices on opposite sides of the wavy-line pattern of the wavy-line pattern bodies that are adjacent are connected by way of the coiled element. When viewing in a radial direction, a circular direction-of the wavy-line pattern bodies is inclined with respect to the radial direction, and a winding direction of one of the coiled elements located at one side in the axial direction with respect to the wavy-line pattern bodies and a winding direction of one other of the coiled elements located at the other side in the axial direction are opposite.
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/92 - Stents in the form of a rolled-up sheet expanding after insertion into the vessel
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
a of the knob portion 19, and the slit 21 extends in the axis direction from an inner peripheral portion at the apex of the wavy-line pattern of the circular body.
A61F 2/88 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
A61F 2/90 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/0225 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
85.
Methods and devices to modulate the autonomic nervous system via the carotid body or carotid sinus
In some embodiments, sympathetic nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 18/02 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 19/02 - Protective casings or covers for appliances or instruments, e.g. boxes or sterile covers; Instrument tables or cupboards; Doctors' bags
A system to modulate an autonomic nerve in a patient utilizing transcutaneous ultrasound energy delivery includes a processor comprising an input for receiving information regarding energy and power to be delivered to a treatment region containing the nerve, and an output for outputting a signal, wherein the processor is configured to determine a position of a reference target from outside the patient to localize the nerve relative to the reference target, a therapeutic energy device comprising a transducer for delivering ultrasound energy from outside the patient, a controller to control an aiming of the transducer based at least in part on the signal from the processor, and an imaging system coupled to the processor or the therapeutic energy device.
A system for applying focused ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of piezoelectric elements, a controller configured to control at least a subset of the piezoelectric elements so that at least one of the piezoelectric elements in the subset is in a signal transmitting mode, in a signal sensing mode, or both, a first platform on which the piezoelectric elements are coupled and a second platform, wherein the second platform is configured to support at least a part of the patient, a programmable generator configured to generate output power for one or more of the piezoelectric elements, and a programmable processor configured to process a signal sensed by at least one of the piezoelectric elements.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61B 5/0225 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 18/18 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61B 5/0225 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A system for applying high intensity ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of ultrasound elements, a controller configured to individually control a phasing of each of the ultrasound elements, a platform on which the ultrasound elements are coupled, wherein the platform is configured to support at least a part of the patient, a programmable generator configured to generate an output power for at least one of the ultrasound elements, and a programmable processor configured to process a signal transmitted from one of the ultrasound elements and reflected back from tissue, and determine a tissue characteristic based on the reflected signal.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A system for treatment includes a focused ultrasound energy source for placement outside a patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of an autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy from outside the patient to the nerve located inside the patient to treat the nerve.
A method to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel, includes placing the patient on a table in a substantially flat position, moving a transducer into a position inferior to ribs, superior to an iliac crest, and lateral to a spine of the patient, maintaining the transducer at the position relative to the patient, and delivering focused ultrasound energy through the skin of the patient without traversing bone, wherein the direction of the focused ultrasound is directed from a lower torso to an upper torso of the patient.
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 5/0225 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.
A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.
In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another. In some embodiments, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A system for treatment of an autonomic nervous system of a patient includes a focused ultrasound energy source for placement outside the patient, wherein the focused ultrasound energy source is configured to deliver ultrasound energy towards a blood vessel with a surrounding nerve that is a part of the autonomic nervous system inside the patient, and wherein the focused ultrasound energy source is configured to deliver the ultrasound energy based on a position of an indwelling vascular catheter.
A61H 1/00 - Apparatus for passive exercisingVibrating apparatusChiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
A61B 5/0225 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.
A method of treatment includes delivering an agent into a patient, and providing energy inside the patient so that the energy can interact with the agent to treat a nerve. A system for treatment includes a source of agent for delivery into a patient, and an energy source for providing energy inside the patient so that the energy can interact with the agent to treat a nerve.
patents
