Orthox Limited

United Kingdom

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A61F 2/30 - Joints 5
A61L 27/22 - Polypeptides or derivatives thereof 5
A61L 27/56 - Porous or cellular materials 5
A61L 27/52 - Hydrogels or hydrocolloids 3
A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof 2
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Found results for  patents

1.

Implantable tissue repair devices

      
Application Number 16615357
Grant Number 11717410
Status In Force
Filing Date 2018-05-22
First Publication Date 2020-05-21
Grant Date 2023-08-08
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Walker, Robert Alan
  • Armstrong, Ben
  • Skaer, Nicholas James Vavasour

Abstract

An implantable tissue repair device containing a body having a biocompatible hydrogel and a plurality of tissue anchoring elements projecting from the body, where the anchoring elements are integrally formed with the body and have the same biocompatible hydrogel as the body, and the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

IPC Classes  ?

2.

IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME

      
Application Number GB2018051349
Publication Number 2018/224800
Status In Force
Filing Date 2018-05-18
Publication Date 2018-12-13
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Skaer, Nicholas James Vavasour
  • Walker, Robert Alan

Abstract

The invention provides for an implantable tissue repair device for the repair, replacement or augmentation of a tissue, the device comprising a biocompatible solvated structural material, wherein at least part of the structural material is in a compressed and/or dried state.

IPC Classes  ?

3.

IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME

      
Application Number GB2018051381
Publication Number 2018/215752
Status In Force
Filing Date 2018-05-22
Publication Date 2018-11-29
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Walker, Robert Alan
  • Armstrong, Ben
  • Skaer, Nicholas James Vavasour

Abstract

The current invention provides for an implantable tissue repair device comprising: a body comprising a biocompatible hydrogel; and a rigid support at least partly located within the body or device, or connected to the body or device.

IPC Classes  ?

4.

IMPLANTABLE TISSUE REPAIR DEVICES AND METHODS FOR MANUFACTURING THE SAME

      
Application Number GB2018051385
Publication Number 2018/215756
Status In Force
Filing Date 2018-05-22
Publication Date 2018-11-29
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Walker, Robert Alan
  • Armstrong, Ben
  • Skaer, Nicholas James Vavasour

Abstract

The invention provides for an implantable tissue repair device comprising; a body comprising a biocompatible hydrogel; and a plurality of tissue anchoring elements projecting from the body; wherein the anchoring elements are integrally formed with the body and comprise the same biocompatible hydrogel as the body, and wherein the anchoring elements, in use, are arranged to enter apertures in a tissue and anchor the device to the tissue.

IPC Classes  ?

5.

Implantable repair device

      
Application Number 14351952
Grant Number 09943412
Status In Force
Filing Date 2012-10-18
First Publication Date 2014-09-18
Grant Date 2018-04-17
Owner ORTHOX LIMITED (United Kingdom)
Inventor Skaer, Nicholas

Abstract

An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 μm when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mold, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mold is adapted to provide at least one smooth surface.

IPC Classes  ?

6.

AN IMPLANTABLE REPAIR DEVICE

      
Application Number GB2012052583
Publication Number 2013/057497
Status In Force
Filing Date 2012-10-18
Publication Date 2013-04-25
Owner ORTHOX LIMITED (United Kingdom)
Inventor Skaer, Nicholas

Abstract

An implantable repair device for the repair, augmentation or replacement of tissue, the device comprising silk fibroin and wherein the device comprises a smooth surface and a porous surface. The smooth surface is defined as a surface having a measured Sa value of less than approximately 0.1µm when using Atomic Force Microscopy (using, for example, the Bruker Dimension Icon System), when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. Also covered is a method of preparing an implantable repair device or a portion or layer of such a device for the repair, augmentation or replacement of tissues, the method comprising the steps of: preparing a gel from a fibroin solution in a mould; preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel; and creating at least a porous surface on said device, wherein in preparing the gel from the fibroin solution, a portion of the mould is adapted to provide at least one smooth surface.

IPC Classes  ?

7.

Implantable material and a method for the preparation thereof

      
Application Number 13368707
Grant Number 08337938
Status In Force
Filing Date 2012-02-08
First Publication Date 2012-06-07
Grant Date 2012-12-25
Owner Orthox Limited (United Kingdom)
Inventor
  • Knight, David Philip
  • Skaer, Nicholas James Vavasour
  • Collins, Andrew Michael
  • Gheysens, Tom Louis Dirk
  • Holland, Christopher

Abstract

A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

IPC Classes  ?

  • A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

8.

AN IMPLANTABLE MATERIAL FOR THE REPAIR, AUGMENTATION, OR REPLACEMENT OF BONE AND A METHOD FOR THE PREPARATION THEREOF

      
Application Number GB2009050727
Publication Number 2009/156760
Status In Force
Filing Date 2009-06-24
Publication Date 2009-12-30
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Knight, David
  • Skaer, Nicholas
  • Collins, Andrew
  • Gheysens, Tom, Louis, Dirk

Abstract

A method for the preparation of an implantable material for the repair, augmentation or replacement of bone from a fibroin solution, the method comprising the steps of: preparing a gel from the fibroin solution; preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, wherein the step of preparing the gel from the fibroin solution is performed in the presence of phosphate ions. The material may be treated with calcium ionstoform a fibroin-apatite. A further method comprises the step of treating the material with an isocyanate. The invention also extends to a method for the preparation of an implantable material, wherein a regenerated fibroin solutionis used. Also, there is an implantable material and an implant.

IPC Classes  ?

  • A61L 27/22 - Polypeptides or derivatives thereof
  • A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
  • A61L 27/56 - Porous or cellular materials

9.

REGENERATED SILK FIBRON SOLUTION PREPARED BY TREATING WITH AN IONIC REAGENT

      
Document Number 02723241
Status In Force
Filing Date 2009-04-30
Open to Public Date 2009-11-05
Grant Date 2016-03-29
Owner
  • ORTHOX LIMITED (United Kingdom)
  • DAVID PHILIP KNIGHT (United Kingdom)
Inventor
  • Knight, David Philip
  • Skaer, Nicholas James Vavasour
  • Collins, Andrew Michael
  • Gheysens, Tom Louis Dirk
  • Holland, Christopher

Abstract

The present invention provides a method for the preparation of an improved regenerated silk fibroin solution suitable for use in an implantable material. The method comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25.degree.C; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25.degree.C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

IPC Classes  ?

  • A61L 27/22 - Polypeptides or derivatives thereof
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/56 - Porous or cellular materials
  • C08J 3/07 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from polymer solutions
  • C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
  • D01C 3/02 - De-gumming silk

10.

AN IMPLANTABLE MATERIAL AND A METHOD FOR THE PREPARATION THEREOF

      
Application Number IB2009051775
Publication Number 2009/133532
Status In Force
Filing Date 2009-04-30
Publication Date 2009-11-05
Owner ORTHOX LIMITED (United Kingdom)
Inventor
  • Knight, David Philip
  • Skaer, Nicholas James Vavasour
  • Collins, Andrew Michael
  • Gheysens, Tom, Louis, Dirk
  • Holland, Christopher

Abstract

A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25°C; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between -0.001 and -0.05 at 25°C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

IPC Classes  ?

  • A61L 27/22 - Polypeptides or derivatives thereof
  • A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/56 - Porous or cellular materials
  • D01C 3/02 - De-gumming silk
  • C08J 3/07 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from polymer solutions
  • C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof