The invention relates to a connection system for connecting an inside environment of a compartment to an environment outside said compartment, said compartment being isolated relative to the outside environment and said connection system, said connection system comprising a blocking device.
A connecting member is provided between an inside environment of a compartment and an environment outside the compartment. The compartment is isolated relative to the outside environment and the compartment comprising a communication orifice defined by a first connector connecting element. The connecting member comprises a main body arranged to cooperate with the communication orifice of the isolated compartment. The main body comprises a second connector or connecting element complementary to the first connecting element of the communication orifice so as to form a tight connection between the first connecting element and the second connecting element, the main body further being crossed through by a tubing comprising a first end on the side of the outside environment and a second end on the side of the inside environment.
A hollow needle comprising a shaft having a distal portion suitable for passing through an elastomer closure of a container, said shaft extending in a longitudinal direction and having a central longitudinal axis, and having an internal longitudinal conduit therein for the flow of liquid and one or more orifices communicating between the conduit and the exterior of the needle, the distal portion of the shaft being provided with a pointed end that has a profile comprising a cutting edge in the form of two part cutting edges converging in the longitudinal direction to meet at the needle point, each part cutting edge extending in a straight line in a widthways direction across a plane including the central longitudinal axis, on both widthways sides of the cutting edge the pointed end having a profile which is a non-cutting surface, wherein the pointed end of the needle tapers from an outer surface of said distal portion toward the point of the needle, and the distance, measured in a further plane defined by said two part cutting edges between the outermost ends of said part cutting edges, is smaller than the largest outer dimension of said distal portion, measured perpendicular to said central axis in said further plane.
A closure system for a vial comprising: an elastic closure part to engage the mouth opening, a clamp part to hold the closure part in a closing relationship with the mouth opening, the clamp part defining an upper aperture through which a region of the upper surface of the closure part is exposed when the clamp part is engaged with the vial, a cover part to engage the clamp part to cover the exposed region, the cover part engaging with the closure part to provide two or more concentric ring-shaped seals, at least part of the cover part being removable from the vial to allow access to the closure.
B65D 51/20 - Caps, lids, or covers co-operating with an inner closure arranged to be opened by piercing, cutting, or tearing
B65D 41/60 - Deformable caps combined with resilient stoppers to permit re-use as temporary closures
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
A hollow needle comprising a shaft (11) having a distal portion (2) suitable for passing through an elastomer closure of a container, said shaft extending in a longitudinal direction and having a central longitudinal axis (L), and having an internal longitudinal conduit (7) therein for the flow of liquid and one or more orifices (8) communicating between the conduit and the exterior of the needle, the distal portion of the shaft being provided with a pointed end (3) that has a profile comprising a cutting edge in the form of two part cutting edges (16, 17) converging in the longitudinal direction to meet at the needle point (18), each part cutting edge extending in a straight line in a widthways direction across a plane including the central longitudinal axis (L), on both widthways sides of the cutting edge the pointed end having a profile which is a non-cutting surface (19, 20), wherein the pointed end of the needle tapers from an outer surface of said distal portion toward the point of the needle, and the distance (41), measured in a further plane defined by said two part cutting edges between the outermost ends of said part cutting edges, is smaller than the largest outer dimension (42) of said distal portion, measured perpendicular to said central axis in said further plane.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61J 1/14 - Containers specially adapted for medical or pharmaceutical purposes DetailsAccessories therefor
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
A process for reducing the oxygen concentration in a container (17) prior to filling the container with a liquid by passing a hollow filling needle (40) through a puncturable part (16) of the container wall, in which the empty container (17) is enclosed within an envelope (21) which is less permeable to oxygen than the container wall (11). The process is suitable for use with vials having a puncturable closure.
B65B 55/19 - Sterilising contents prior to, or during, packaging by adding materials intended to remove free oxygen or to develop inhibitor gases, e.g. vapour-phase inhibitors
B65D 77/00 - Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
B65D 81/26 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, fluids, e.g. exuded by contentsApplications of corrosion inhibitors or desiccators
−1, preferably being a base thermoplastic elastomer compounded with a colorant which comprises a Pantone 4597C pigment mixed with a carrier material. The elastomer is suited for use as a pharmaceutical vial closure which can be punctured by a filling needle and the puncture hole heat sealed by a focused laser.
C09B 67/00 - Influencing the physical, e.g. the dyeing or printing, properties of dyestuffs without chemical reaction, e.g. by treating with solventsProcess features in the making of dyestuff preparationsDyestuff preparations of a special physical nature, e.g. tablets, films
A process for making a medicinal vial in which a vial and a closure are moulded in parallel in respective vial and closure moulds, then the closure and vial are automatically assembled together, all in a sterile environment. An apparatus for performing this process is also provided. By the process and apparatus of the invention sealed vials with a sterile interior may be made.
B29C 45/00 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mouldApparatus therefor
B29C 70/80 - Moulding sealing material into closure members
B23P 21/00 - Machines for assembling a multiplicity of different parts to compose units, with or without preceding or subsequent working of such parts, e.g. with programme control
B23Q 7/00 - Arrangements for handling work specially combined with or arranged in, or specially adapted for use in connection with, machine tools, e.g. for conveying, loading, positioning, discharging, sorting
B65B 55/02 - Sterilising, e.g. of complete packages
15.
Closure system for a vial, vial, method of closing and filling a vial and stand for a vial
A closure system for a pharmaceutical vial, comprising an elastomer closure part, a clamp part which holds the closure part in engagement with the mouth of the vial, and a cover part which engages with the clamp part. The interior of the closure part is profiled to minimize retention of residual liquid therein.
A process for making a medicinal vial (10) in which a vial (10) and a closure (20) are moulded in parallel in respective vial and closure moulds (30, 40), then the closure (20) and vial (10) are automatically assembled together, all in a sterile environment. An apparatus for performing this process is also provided. By the process and apparatus of the invention sealed vials with a sterile interior may be made.
B29C 45/17 - Component parts, details or accessoriesAuxiliary operations
B29C 65/00 - Joining of preformed partsApparatus therefor
B29C 69/00 - Combinations of shaping techniques not provided for in a single one of main groups , e.g. associations of moulding and joining techniquesApparatus therefor
B65B 31/02 - Filling, closing, or filling and closing, containers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
