The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants, and any related tobacco products, having low nicotinic alkaloid content. Tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotinic alkaloids (e.g., nicotine) compared to both naturally-occurring and transgenic tobacco plants, and thus represent a commercially valuable alternative to currently available tobacco varieties.
Disclosed herein is a novel Cas9 protein. Further described herein are fusion proteins, compositions, and methods comprising the same. The novel Cas9 protein may be used, for example, in compositions and methods for modulating expression of a gene, for correcting a mutant gene, and for treating a disease.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/90 - Stable introduction of foreign DNA into chromosome
3.
Side-Channel Aware Training for Commercial Machine Learning Accelerators
Various examples are provided related to side-channel awareness. In one example, a method for side-channel awareness training includes generating trained models by stochastically training neural network models using a common training dataset; generating an inference model based upon random selection of parameters from one or more of the trained models; and training the inference model with the selected parameters. The trained inference model can be executed on an edge Tensor Processing Unit (TPU). The models can be trained offline. An input signal can be processed using the trained inference model to generate an output signal for transmission.
The present technology provides methods of combining mutations in N-methylputrescine oxidase (MPO) gene isoforms with mutations in the three major berberine bridge enzyme-like (BBL) genes to produce low-nicotine tobacco plants and which prevent the accumulation of anatabine in the tobacco plants. Also provided are methods of combining these mutations to produce tobacco plants, tobacco cells, and tobacco products having reduced nicotine content and which avoid the unwanted consequence of elevated anatabine levels in the tobacco plants, cells, and products.
A system, method, and device for retaining an implanted medical device is disclosed, the device including: a sleeve body extending circumferentially around a first longitudinal axis. The sleeve body defines a first aperture on a first end of the sleeve body and a second aperture on a second end of the sleeve body. The second end is spaced apart longitudinally from the first end of the sleeve body. The device further includes a sheath coupled to an inner surface of the sleeve body and extending circumferentially around a second longitudinal axis. The sheath defines a third aperture on a first end of the sheath and a fourth aperture on a second end of the sheath. The second end of the sheath is spaced apart from the first end of the sheath.
A polymer solar cell ink for organic solar cell (OSC) devices is provided. The polymer solar cell ink includes at least one solid state additive. The polymer solar cell ink further includes a donor polymer. The polymer solar cell ink further includes a nonfullerene acceptor (NFA).
The present disclosure relates to a photoreactor and method of use thereof. In an aspect, the photoreactor can be configured as a solar panel comprising a channel containing a heterogeneous photocatalyst. When water or another hydrogen-containing liquid is pumped through the photoreactor, it contacts the photocatalyst in the presence of UV or visible irradiation, simultaneously releasing hydrogen and separating the hydrogen via a gas-permeable membrane. In an aspect, the photoreactor can be used in a method for continuous production of high-purity H2 gas, the method comprising dehydrogenating tetrahydroquinoline (THQ) to form quinoline under visible light using a Rh/TiO2 heterogeneous photocatalyst. In another aspect, the catalyst includes Rh particles photodeposited on TiO2 microparticles. In a further aspect, the method can include regenerating THQ from quinoline using a water gas shift (WGS) reaction.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
B01J 8/06 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds in tube reactorsChemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds the solid particles being arranged in tubes
B01J 19/24 - Stationary reactors without moving elements inside
C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts
10.
COMPOSITIONS AND METHODS RELATED TO SOMATIC EMBRYOGENESIS IN ROSE PLANTS
The present disclosure provides compositions and methods for producing a rose plant using somatic embryogenesis. In particular, the present disclosure provides novel methods and media for rose callus induction, embryoid suspension, and embryo regeneration. Unlike currently available techniques, the novel compositions and methods provided herein produce high yields of competent cells and high frequencies of rose somatic embryogenesis.
The present disclosure provides compositions and methods related to the culturing of trophoblast stem cells (TSCs). In particular, the present disclosure provides novel formulations and methods for inducing and maintaining trophoblast stem cells obtained from cytotrophoblasts (CTBs) obtained from a placenta at birth. The compositions and methods described herein allow for the development of in vitro models of early human placental development and establish a platform for therapeutic discoveries.
The present disclosure provides materials and methods related to increasing viral resistance of plants. In particular, the present disclosure provides antiviral hairpin constructs having a stem region, wherein the stem region includes one or more polynucleotide sequences, wherein each of the one or more polynucleotide sequences individually have at least 70% identity or complementarity to a sequence from a target virus. Also provided are methods of increasing virus resistance or preventing viral infection in a plant comprising providing an antiviral hairpin construct or a nucleic acid encoding an antiviral hairpin construct to the plant.
‘NCCH3’ is a new cultivar of flowering dogwood with a unique combination of traits including large white bracts, large glossy leaves, a fast growth rate, and showy fall color.
The present disclosure provides compositions and methods related to opioid detection. In particular, the present disclosure provides aptamer-based colorimetric assays for the visualization and identification of specific opioids (natural, semi-synthetic, synthetic and the derivatives and analogs thereof) in a manner that is rapid, specific, and sensitive.
A wearable ultrasound device may include an array of ultrasound transducers, wherein each ultrasound transducer comprises: a matching layer on a top side, an active layer adjacent the matching layer, a first backing layer adjacent the active layer, a second backing layer adjacent the first backing layer; and an epoxy bonding material interspaced between each of the matching layer, the active layer, the first backing layer, and the second backing layer, wherein the array of ultrasound transducers is surrounded by a PDMS filling, whereby the active layer is configured to communicate a signal in response to mechanical deformation.
Various examples are provided related to ceramic substrate windings and their application. In one example, a ceramic substrate coil includes a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate, the at least one coil trace forming at least a partial loop about the ceramic substrate surface. In another example, a permanent magnet machine includes a rotor and a stator including ceramic coils. Each of the ceramic coils include a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate. The ceramic coils are positioned, and the coil traces are connected to form a stator winding of the permanent magnet machine.
H02K 3/26 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors consisting of printed conductors
H02K 1/12 - Stationary parts of the magnetic circuit
H02K 3/02 - Windings characterised by the conductor material
H02K 9/19 - Arrangements for cooling or ventilating for machines with closed casing and closed-circuit cooling using a liquid cooling medium, e.g. oil
H02K 9/22 - Arrangements for cooling or ventilating by solid heat conducting material embedded in, or arranged in contact with, the stator or rotor, e.g. heat bridges
17.
ATOMIC LAYER ETCHING OF METALS USING NOVEL CO-REACTANTS AS HALOGENATING AGENTS
The disclosed and claimed subject matter relates to thermal atomic layer etch (ALE) processing of metals and alloys thereof (e.g., cobalt and cobalt alloys) using thionyl chloride (SOCl2) or a combination of thionyl chloride and pyridine.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
19.
CHROMATOGRAPHY MEDIUM FOR PURIFYING TARGET BIOLOGICS
The present disclosure provides materials and methods related to the purification of a biologic. The present disclosure provides materials and methods related to the purification of a biologic. In particular, the present disclosure provides a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSeparationPurification by chromatography
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
21.
POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
Described herein are polymeric fluorophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric fluorophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric fluorophores and methods of preparing and using the same.
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
22.
ULTRASOUND TRANSDUCER AND ARRAY FOR INTRAVASCULAR THROMBOLYSIS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventor
Jiang, Xiaoning
Kim, Jinwook
Ma, Jianguo
Dai, Xuming
Abstract
A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
23.
PARALLELING POWER SEMICONDUCTORS WITH DIFFERENT SWITCHING FREQUENCIES
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor
G05D 3/20 - Control of position or direction using feedback using a digital comparing device
B62D 33/10 - Superstructures for load-carrying vehicles characterised by the connection of the superstructure to the vehicle frame comprising means for the suspension of the superstructure on the frame
B64D 9/00 - Equipment for handling freightEquipment for facilitating passenger embarkation or the like
B65D 88/14 - Large containers rigid specially adapted for transport by air
25.
METHODS FOR MANUFACTURING METAL OXIDE INFUSED CONFORMAL COATING MATERIAL AND METAL OXIDE INFUSED CONFORMAL COATING MATERIAL MADE USING SAME
A method for manufacturing and applying a metal oxide coating for shielding an object from particle radiation includes heating a quantity of a resin of a polyurethane system and mixing a metal oxide with the quantity of the resin of the polyurethane system to form a mixture. The method further includes mixing a quantity of a hardener of the polyurethane system with the mixture to form a metal oxide infused conformal coating (MOICC). The method further includes applying the MOICC to an object to shield the object from particle radiation and curing the MOICC.
The present invention relates to tobacco products from plants comprising mutated berberine bridge enzyme-like nucleic acids and the recessive nic1 and/or nic2 alleles and methods of making the same.
Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
29.
BIOSENSOR AND METHODS OF IN-SITU MEASURING OF NUTRIENT CONTENT OF A CROP CULTIVATION SUBSTRATE
The subject matter described herein is directed to systems, detection devices and enzyme sensors for real-time determination of the concentration levels of nutrients in a crop cultivation substrate using thermal signals and change in enthalpy per unit of enzyme. Methods of using the systems, detection devices and enzyme sensors for agricultural applications are described.
C12N 11/14 - Enzymes or microbial cells immobilised on or in an inorganic carrier
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
G01K 7/16 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements
30.
HYDROFORMYLATION PROCESS FOR PREPARING LINEAR AND BRANCHED ALDEHYDES
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
C07C 45/50 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
B01J 23/46 - Ruthenium, rhodium, osmium or iridium
The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluoescence signals for rapid and sensitive quantification of proteins in complex samples.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
32.
SEQUENCING AND STRATEGIES FOR ENHANCING INTRAVASCULAR THROMBUS DISRUPTION WITH PHASE-CHANGE CAVITATION ENHANCING AGENTS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
Inventor
Dayton, Paul Alexander
Kim, Jinwook
Jiang, Xiaoning
Zhang, Bohua
Wu, Huaiyu
Xu, Zhen
Abstract
A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
33.
PROTEIN DEGRADATION SYSTEM, COMPONENTS, AND METHODS
The present disclosure provides components and systems for targeted protein degradation in cells (e.g., in plant cells). In particular, the present disclosure provides a protein containing the Leucine-Rich Repeat (LRR) and novel E3 ligase (NEL) domains of SspH1 for use with Homology Region 1b (HR1b) domain of human PKN1 for degrading target proteins.
In one aspect, the disclosure relates to compositions including a collagen hydrogel and a flavonoid, wherein at least a portion of the collagen hydrogel is crosslinked by the flavonoid, methods of making the cosmetic and pharmaceutical compositions comprising the same, and methods of healing wounds using the same. The disclosed compositions are cytocompatible and can protect cells from oxidative damage through preventing damage from and/or reducing accumulation of reactive oxygen species (ROS). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Compounds comprising a tetrapyrrole macrocycle that includes a radionuclide; a hydrogelator attached to the tetrapyrrole macrocycle; a water solubilizing group attached to the hydrogelator; and a cleavage site that is between the hydrogelator and the water solubilizing group are described herein along with their methods of use. Two or more compounds of the present invention may two or more compounds may self-assemble (e.g., aggregate), optionally in vivo.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
36.
ENCAPSULATION OF NUTRITIONAL AND/OR COMPOUNDS FOR CONTROLLED RELEASE AND ENHANCING THEIR BIOAVAILABILITY BY LIMITING CHEMICAL OR MICROBIAL EXPOSURE
The present invention provides methods for recovering metals, including rare earth metals, from mixed metals. An example is the recovery of metals from electronic waste. The method of separation is based on the inversion and/or lowering of the thermodynamic energy barrier by using one or more stressors applied at appropriate ratios to create lower energy points in the thermodynamic energy landscape of the mixed metals. Example stressors include a) a chemical stress, b) a mechanical stress, c) a thermal stress, d) and electromagnetic radiation and/or light stress, an interfacial stress, and/or a magnetic flux gradient stress.
A non-shedding hybrid nonwoven web comprised of 99% by mass of functional material(s) co-mingled with the filaments. High level of particle retention within the fabric is provided without the aid of adhesives, binders, adhesive polymers, or post processes. This composite web has a multi-layered structure with a uniform distribution of sorptive particles and desired opposed color contrast on each side. The process includes providing two converging streams of blown polymeric filaments, passive feed of functional material(s) in between the filament streams, and collecting the hybrid webs.
D04H 1/407 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing absorbing substances, e.g. activated carbon
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
Methods of mineralizing hemp fiber to provide hemp fibers mineralized with calcium carbonate are described. Also described are mineralized hemp fibers and compositions including the mineralized hemp fibers. The mineralized hemp fibers can be hemp fibers with calcium carbonated deposited on the hemp fiber surface. The compositions including the mineralized hemp fibers can be cementitious or non-cementitious. Also described are methods of preparing “green” concrete comprising mineralized hemp.
The loss of cross-linking abilities in highly substituted alginate scaffolds is a significant problem affecting the use of alginate polymers in implants, cell delivery, and tissue engineering. Disclosed are modified alginate scaffolds that retain their gelation properties under high chemical modification, as well as methods of making and using thereof.
Screw dislocations play a significant role in the growth of crystalline structures by providing a continuous source of surface steps, which represent available sites for crystal growth. Here we show that pure screw dislocations can become helical by the absorption of defects (e.g., vacancies), and develop attractive interaction with another helical dislocation to form a double helix of screw dislocations. These single and double helix of screw dislocations can result in the formation of interesting nanostructures with large Eshelby twists. Examples of the formation of a double helix during thermal annealing of screw dislocations in magnesium oxide are presented. These large effective Burgers also unravel the mechanism for the formation of nanopipes and micropipes with hollow cores and nanotubes with Eshelby twists in technologically important materials, such as SiC, GaN and ZnO that are utilized in a variety of advanced solid state devices.
This invention relates to methods for increasing phage resistance in Clostridium species through incorporation of novel recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNAs using endogenous CRISPR systems and/or recombinant nucleic acid constructs encoding clostridia Type I-B and Type I-C CASCADE complexes, and/or expression cassettes and vectors comprising the same.
In one aspect, the disclosure relates to catalytic phase transfer sorbents (PTS) for producing hydrogen-enriched syngas from a carbonaceous feedstock, the PTS comprising a formula selected from ABO3 and An+1BnO3n+1, wherein A comprises one or more alkali metals or alkaline earth metals, wherein B comprises one or more transition metals, and wherein X comprises an anion. Also disclosed is a system for hydrogen generation from carbonaceous feedstocks, the system comprising a gasifier unit for production of H2-rich syngas and a regenerator unit for regeneration of spent PTS. Further disclosed herein is a method for hydrogen generation from carbonaceous feedstocks using the disclosed systems. The disclosed systems can be operated isothermally through 10 or more cycles without degradation in performance, while the disclosed methods can yield 50% or more H2 relative to carbon-containing species. In some aspects, the methods produce little to no CO2.
B01J 8/26 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles according to "fluidised-bed" technique with two or more fluidised beds, e.g. reactor and regeneration installations
B01J 8/18 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with fluidised particles
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01J 23/92 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides provided for in groups
B01J 35/40 - Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
B01J 38/30 - Treating with free oxygen-containing gas in gaseous suspension, e.g. fluidised bed
C01B 3/44 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts using moving solid particles using the fluidised bed technique
A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
The disclosure relates to nonwoven fabric including a nonwoven material having a first surface and an opposing second surface, wherein the first surface has a first average surface charge and the second surface has a second average surface charge, the first average surface charge being different from the second average surface charge, wherein the nonwoven material includes a first plurality of fibers including a first polymer and a second plurality of fibers including a second polymer different from the first polymer. A method for imparting surface charge to a nonwoven N61824_1570Wabric is also provided.
D04H 1/492 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties the fleeces or layers being consolidated by mechanical means, e.g. by rolling by needling or like operations to cause entanglement of fibres by fluid jet
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
D04H 3/11 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between yarns or filaments made mechanically by fluid jet
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
48.
METHODS AND SYSTEMS FOR TRANSIENT TISSUE TEMPERATURE MODULATION
University of Pittsburgh - Of the Commonwealth System of Higher Education (USA)
North Carolina State University (USA)
Blatek Industries, Inc. (USA)
Inventor
Kang, Kim
Chen, Qiyang
Sheng, Zhiyu
Zhang, Bohua
Kim, Howuk
Wu, Huaiyu
Jiang, Xiaoning
Chen, Mengyue
Geng, Xuecang
Abstract
Ultrasound systems and methods of use are provided for rapidly heating a target area of a subject. The ultrasound system can include at least one imaging transducer array for imaging the target area, and at least two spaced-apart heating transducer arrays for heating the target area. The heating transducer arrays can be separated by the imaging transducer array on an ultrasound probe.
This invention is directed to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and recombinant nucleic acid constructs encoding clostridia Type I-B CASCADE complexes, expression cassettes and vectors comprising the same, and methods of use thereof for modifying genomes, altering expression, killing one or more cells in a population of cells, and screening or selecting for genomic variants of an organism.
‘XZ 14069’ is a medium to dark green perennial zoysiagrass cultivar with medium-fine texture low incidence of large patch disease and aggressive stoloniferous growth producing high density turf performance ideal for low-management landscaping. It is distinguishable from other cultivars by medium-fine texture, plant architecture and characteristics such as high drought tolerance, turf quality, disease resistance and aggressive establishment from minimal input. ‘XZ 14069’ shows persistence under an array of climates including warm-temperate, warm-humid and hot-arid. ‘XZ 14069’ is also genetically distinct from other zoysiagrass cultivars currently in the marketplace known to the Inventor. ‘XZ 14069’ exhibits very low fertility and no inflorescences have been observed.
Various examples are provided related to monitoring of various biomarkers in wound fluid to indicate a wound status. In one example, a wound sensing system includes a platform for examining a wound; and an array of sensors disposed on the platform. The array of sensors can include one or more fluorometric assay sensor, one or more colorimetric assay sensor, or both. Each of the fluorometric assay sensor can produce a fluorescence intensity proportional to a corresponding target concentration and each of the colorimetric sensor can produce a color change proportional to a corresponding target concentration. In another example, a method includes swiping a wound with an array of sensors of a wound sensing system; waiting for a predetermined amount of time; capturing an image of the of the array of sensors; and analyzing the image to determine one or more analyte concentration based upon fluorescence intensity, color intensity or both.
‘NCORNSP-031SHMG’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its dark red heart shaped leaves, a moderately-compact habit and semi-erect mounding plant architecture. The dark red leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-031SHMG’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-031SHMG’ is shown to be suitable for use as a landscape or containerized plant.
‘NCORNSP-032SCRHI’ is a moderately compact and loosely upright variety with a moderate growth rate and is well branched. It is distinguishable from other ornamental sweetpotato cultivars by its red to burgundy five lobed leaves, a moderately-compact habit and semi-erect mounding plant architecture. The burgundy leaves, uniform color, short internodes, and the plant architecture, which promotes good plant production in the greenhouse for wholesale distributors, distinguishes ‘NCORNSP-032SCRHI’ amongst the current ornamental sweetpotatoes in the marketplace. In greenhouse and field trials, ‘NCORNSP-032SCRHI’ is shown to be suitable for use as a landscape or containerized plant. The production of flowers by ‘NCORNSP-032SCRHI’ is not observed under short-day conditions.
An exemplary method for producing a strain sensor using crack propagation includes opening and blunting includes applying conductive nanowires to a substrate to form a conductive nanowire network on the substrate. The method also includes applying an elastomer to the nanowire network to form a composite layer on top of the conductive nanowire network. The method also includes removing the substrate from the conductive nanowire network, wherein removing the substrate at least partially exposes a surface of the conductive nanowire network. The method further includes cutting intervallic incisions in the surface of the conductive nanowire network, wherein the intervallic incisions extend alternatingly and inwardly from one of two opposing edges of the conductive nanowire network.
G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
Various examples are provided related to Q-silicon, Q-carbon and combinations thereof, and synthesis, properties and applications of Q-silicon and Q-carbon. In one example, a method includes forming a layer of amorphous silicon; melting at least a portion of the layer of amorphous silicon in an undercooled state; and forming Q-silicon by quenching the melted amorphous silicon from the undercooled state. In another example, a Q-silicon includes a random arrangement of tetrahedra, the tetrahedra including dangling bonds, unpaired spins or both. The atomic structure of the Q-silicon is based upon time in an undercooled state before quenching. In another example, a battery anode includes Q-silicon mixed with a polyvinylidene difluoride (PVDF) binder, the Q-silicon including a random arrangement of tetrahedra, the tetrahedra comprising dangling bonds, unpaired spins or both. The battery anode can include Q-carbon and Q-silicon mixed with the PVDF binder.
The present invention provides wearable plant sensors for continuous monitoring of plant physiology by tracking both biochemical and biophysical signals of the plant and its microenvironment. Sensors for detecting volatile organic compounds (VOC), temperature, and humidity are integrated into a single platform. The abaxial leaf attachment position is selected based on the stomata density to improve the sensor signal strength. This versatile platform enables various stress monitoring applications, ranging from tracking plant water loss to early detection of plant pathogens. A machine learning model was also developed to analyze multichannel sensor data for quantitative detection of tomato spotted wilt virus (TSWV) as early as four days after inoculation.
Sustainable paper-based packaging materials, e.g., paper-based food packaging materials, are described. The packaging materials are based on paper formed from fiber derived from waste biomass, such as hemp hurds, mixes containing hemp hurds and hemp bast fibers, bagasse, and cocoa pod husks. Also described are methods of making the packaging materials. The methods can include environmentally friendly pulping and/or bleaching processes.
D21F 11/02 - Processes for making continuous lengths of paper, or of cardboard, or of wet web for fibreboard production, on paper-making machines of the Fourdrinier type
A voice therapy device including a body having an internal passageway with a longitudinal axis that defines an airflow direction; a mouthpiece positioned at a proximal end of the body; and a resistance portion positioned at a distal end of the body, where the resistance portion is adjustable to vary an airflow resistance through the internal passageway. In some embodiments, the voice therapy device includes a sensor electrically coupled to a processor. A system for voice therapy includes the voice therapy device and a software application.
H01L 21/18 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic Table or AIIIBV compounds with or without impurities, e.g. doping materials
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/205 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds including two or more compounds in different semiconductor regions
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventor
Gilger, Brian
Crabtree, Elizabeth
Hirsch, Matthew L.
Abstract
The present disclosure provides compositions and methods related to the treatment of ocular diseases in equines. In particular, the present disclosure provides novel compositions and methods related to the administration of therapeutic compositions comprising AAV-equine IL-10 for the treatment and/or prevention of various ocular diseases (e.g., non-infectious uveitis).
A transparent structure for emitting light is described. The transparent structure comprises an emissive layer (EML) positioned between first and second electrodes. The EML is tuned such that luminance through the first electrode is greater than luminance through the second electrode.
The present disclosure provides compositions, methods, and kits related to DNA transformation in bacteria. In particular, the present disclosure provides novel compositions and methods for enhancing DNA transformation by replicating a DNA methylation pattern used in a bacterial host strain. The compositions, methods, and systems described herein utilize cell-free transcription-translation mixtures and DNA methylation complexes to increase transformation efficiency and efficacy for any bacterial host.
The present disclosure relates generally to test devices comprising a round window membrane and/or an oval window membrane separating two compartments and to the use of such devices in methods for identifying compounds and compositions suitable for use as therapeutics via intratympanic administration.
The present disclosure provides compositions and methods related to nucleic acid molecules having therapeutic activity. In particular, the present disclosure provides nucleic acid molecules comprising one or more aptamers having anticoagulant activity, as well as corresponding antidote nucleic acid molecules capable of modulating anticoagulant activity.
In one aspect, the disclosure relates to an oxide-molten salt (OMS) composite material offering excellent energy storage capacity at low cost. The OMS composite material can be provided in at least three forms, including a porous, perovskite-oxide particle as a matrix having pores filled with unary salt or salt mixtures; an external shell of perovskite-oxide particles and an internal core of salt or a salt mixture; and/or a porous, perovskite-oxide particle as a matrix filled with unary salt or salt mixtures, wherein the whole particle is enclosed with an oxide outer shell. Further in this aspect, the outer shell can be dense but either mixed ionic-electronically conductive or porous. In another aspect, the disclosed methods and systems can be used for grid-scale energy storage by retrofitting existing steam turbine-based power plants and concentrated solar plants. In a further aspect, the disclosed methods, systems, and materials are environmentally benign.
Suspensions include an aqueous medium and a plurality of particles. The particles include polymeric carrier material dispersed throughout the particle and active ingredient dispersed throughout the particle. The polymeric carrier material can be biodegradable, and one example is a cellulose ester. Exemplary active ingredients include an insecticide, a fungicide, and a pesticide. In some instances, the plurality of particles have an average diameter of 25 nm to 5 μm. Exemplary suspensions may be applied to plant surfaces.
A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
Exemplary catalysts may comprise a two-dimensional substrate and at least one organometallic compound bonded to the two-dimensional substrate. The at least one organometallic compound may comprise a carbonyl group. Exemplary methods of preparing a polymer product may comprise combining a catalyst with an alcohol and an ester in a solvent, thereby generating a mixture, and obtaining the polymer product from the mixture.
B01J 31/12 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
Various examples are provided related to resonance tracking broadband energy harvesting. In one example, a resonance tracking energy harvester includes a pendulum adaptive frequency oscillator including an adjustable pendulum rod and control circuitry that can adjust a length of the adjustable pendulum rod in response to a sensed forcing frequency. In another example, a method of resonance tracking energy harvesting, includes sensing a forcing frequency applied to a pendulum adaptive frequency oscillator comprising an adjustable pendulum rod; and adjusting a length of the adjustable pendulum rod in response to the sensed forcing frequency. Oscillation and/or vibration of the pendulum adaptive frequency oscillator can be converted.
H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators
G05D 3/12 - Control of position or direction using feedback
72.
COMPOSITIONS AND METHODS FOR TREATING PAIN IN ANIMALS
The present disclosure provides compositions and methods related to the treatment and/or reduction of pain in an animal. In particular, the present disclosure provides novel compositions and methods for treating and/or reducing pain in an animal (e.g., a pig) by administering an analgesic intranasally. The composition and methods described herein provide a more convenient and effective means for treating and/or reducing pain in an animal (e.g., pain associated with industrial processing) in a manner that also improves the animal's health and welfare.
The present disclosure provides a nonwoven material including a blend of a first plurality of monocomponent fibers and a second plurality of segmented fibers having segments of a first polymer and segments of a second polymer different from the first polymer, wherein the nonwoven material includes about 75 to about 95% by weight of the monocomponent fibers, and about 5 to about 25% by weight of the segmented fibers, based on the total weight of the nonwoven material, and wherein the segmented fibers are at least partially fibrillated or split. An air filter including the nonwoven material is also provided.
B01D 29/03 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with flat filtering elements self-supporting
D01F 6/06 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyolefins from polypropylene
D01F 8/14 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyester as constituent
74.
POPULATION GENETICS APPROACH TO BIOLOGICAL CONTROL OF MYCOTOXIN PRODUCTION
The invention relates to methods for controlling mycotoxin production in field populations of heterothallic and homothallic filamentous fungi through application of biocontrol compositions comprising selected strains of the heterothallic and homothallic filamentous fungi, the selected strains having a lineage of low mycotoxin production or no mycotoxin production and having opposite mating types (heterothallic) or both mating types (homothallic) (e.g., MAT1-1, MAT1-2).
A system for estimating moisture in soil includes a first antenna for transmitting RF signals, second antennas for receiving RF signals, and a controller configured to: emit, via the first antenna, RF signals at a plurality of frequency increments; determine a channel frequency response (CFR) based on amplitude attenuation and phase change of reflected RF signals detected by the second antennas; determine a power delay profile (PDP) for the second antennas based on the CFRs; extract a subset of the reflected RF signals using peak detection on the PDPs; and for each layer of the soil and for each of the subset of reflected RF signals, determine: i) a wavelength of the reflected RF signal in the layer, ii) an estimated depth of the layer, iii) a dielectric permittivity of the layer based on the wavelength, and iv) an estimated moisture content of the layer based on the dielectric permittivity.
Various examples are provided related to photovoltaic systems that utilize multiple current source inverters. In one example, a solar inverter system includes DC-DC current source converters coupled to a DC link and a grid-frequency inverter coupled to the DC link. The DC power can be converted from energy obtained from a photovoltaic (PV) panel coupled to the DC-DC current source converters and the grid-frequency inverter can generate AC power from the DC power provided to the DC link.
H02M 7/515 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a thyratron or thyristor type requiring extinguishing means using semiconductor devices only
H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
77.
Compositions and methods for conferring resistance to geminivirus
Provided are expression cassettes that can be used to express proteins in plants. In some embodiments, the expression cassettes include polynucleotides that encode polypeptides that are at least 96% identical to SEQ ID NO: 2 operably linked to a promoter and a transcription terminator and optionally a tag sequence. Also provided are recombinant vectors, cells, and transgenic plants, progeny, and seeds that include the presently disclosed expression cassettes, and methods for using the disclosed expression cassettes to alter geminivirus resistance and suppress virus-induced leaf chlorosis, leaf curling, or both in plants.
A device can automatically count, speciate, and determine infectivity of eggs of parasites in food animals. The device can include a chamber that can receive a sample specimen. Additionally, the device can include a light source. The light source can illuminate a field of view of the sample specimen in the chamber. The device can further include a microscope objective to magnify the field of view of the sample specimen. The device can include a camera. The camera can image the field of view of the sample specimen. The camera can further produce an on-site dataset of images. Additionally, the camera can provide the on-site dataset of images to a trained machine-learning model for analysis of at least one species of parasites.
An implantable device is provided that includes a tubular body with at least one open end, defining an inner space, a cap closing the at least one open end and having an inner surface on one side and an outer surface on the other side, the inner surface facing the inner space, and a circuit board being placed in the inner space, having an active surface, a board electrode disposed on the active surface, and a wireless communication circuit to communicate outside of a body, biological information obtained via the board electrode. Moreover, a recess and an inner electrode are disposed on the inner surface of the cap, and the circuit board is disposed in the recess, and the inner electrode is electrically connected to the board electrode. An outer electrode is disposed on the outer surface of the cap and is electrically connected to the inner electrode.
Board of Trustees of Southern Illinois University (USA)
Inventor
Theis, Thomas
Abdulmojeed, Mustapha
Lehmkuhl, Sören
Tomhon, Patrick
Mandzhieva, Iuliia
Chekmenev, Eduard Y.
Adelabu, Isaiah
Kabir, Mohammad
Nantogma, Shiraz
Ettedgui, Jessica
Swenson, Rolf Eric
Goodson, Boyd
Abstract
In one aspect, the disclosure relates to hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Devices, systems, and methods for characterizing material samples. In one aspect, a device for characterizing a sample includes a substrate configured for receiving a sample thereon; an optical fiber probe comprising a first end positioned near the sample and a second end that is bifurcated to include one or more first fiber configured for connection to a first light emitting device and one or more second fiber configured for connection to a spectrometer; a reflectance module coupled to the substrate; and a second light emitting device positioned near the sample. The optical fiber probe is configured for selectively obtaining at the spectrometer both a reflectance absorbance measurement of the sample associated with the first light emitting device and a photoluminescence measurement of the sample associated with the second light emitting device.
Cercis plant, referred to by its cultivar name, ‘NC2017-113’, is disclosed. The new variety is characterized by its white-colored flowers. The new variety is also characterized by its small, thick, glossy, and green-colored foliage. A moderately slow growing and compact growth habit is displayed.
‘XSA 11377’ is a new St. Augustinegrass cultivar that is fast to establish, has good levels of shade and drought tolerances, and has superior turf quality. It is distinguishable from other cultivars by its medium-fine texture, aggressive stoloniferous growth, improved sod strength, and improved shade tolerance. ‘XSA 11377’ shows gray leaf spot and chinch bug tolerance, and maintains above average turf quality under normal management practices. ‘XSA-11377’ is also genetically distinct from other St. Augustinegrass cultivars currently in the marketplace known to the Inventor.
Various examples are provided related to DC microgrid control. In one example, a system includes a mesh DC microgrid network having at least 4 microgrid DC nodes. The mesh DC microgrid network can be organized as clusters of three node DC microgrid systems, where each cluster include three of the at least 4 microgrid DC nodes. In each cluster, one of DC microgrid nodes is a pivot node that links remaining clusters together within the mesh DC microgrid network. Each DC microgrid node of the mesh DC microgrid network is directly connected to the pivot node. In another example, a mesh DC microgrid network includes one or two remaining microgrid DC nodes directly connected to a pivot node by a tie-line including a tie-line current sensor. One or more converters at the remaining DC microgrid nodes can be controlled using feedforward control with droop control using tie-line current sensor information.
Cercis plant, referred to by its cultivar name, ‘NC2017-92’, is disclosed. The new variety is characterized by its light, purple-colored flowers. The new variety is also characterized by its small and gold-colored foliage. A moderately slow growing, highly branched and compact growth habit is displayed.
Disclosed are fibrin-specific nanogels. The fibrin-specific nanogels can comprise a fibrin binding moiety conjugated to a polymeric matrix (e.g., a crosslinked polyacrylamide matrix). By varying the morphology of fibrin-specific nanogels (e.g., by varying the crosslinker density and/or the three-dimensional structure of the fibrin-specific nanogels), fibrin-specific materials which mimic the biophysical characteristics of platelets can be formed. The resulting materials can be used in a variety of biomedical applications (e.g., for drug delivery, to promote wound healing, to treat thrombotic events, and to treat coagulative disorders).
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61L 26/00 - Chemical aspects of, or use of materials for, liquid bandages
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
h The present disclosure provides compositions, methods, and systems related to template-mediated genome editing and modification. In particular, the present disclosure provides novel genome modification technology involving site-specific chemical modification of a nucleotide to introduce a replication-blocking lesion. The compositions, methods, and systems described herein facilitate efficient site-specific genome modification of a DNA target, while minimizing the unintended edits and cellular toxicity associated with current genome editing approaches.
Spin coating systems and methods. In one aspect, a spin coater assembly is provided. The spin coater assembly includes a spinner configured for receiving a substrate thereon, a plurality of material dispensers, an arm assembly configured to selectively position one of the plurality of material dispensers over the substrate, and a controller in communication with each of the spinner, the plurality of material dispensers, and the arm assembly.
The present disclosure provides materials and methods relating to bioprinting. In particular, the present disclosure provides compositions, systems, and methods for 3D bioprinting plant cells according to pre-determined spatiotemporal patterns to facilitate the high-throughput regeneration of plants having reduced variability.
Various examples are provided related to overcurrent protection for composite power semiconductor switches comprising a high voltage power switch in series with a low voltage non-linear element. In one example, a system includes a blocking diode connected to a sensing node of a composite switching device; a resistor connected in series with the blocking diode and to a desaturation detection input of a gate driver circuit; and a blanking capacitor connected between the desaturation detection input and a common voltage reference of the gate driver circuit. The gate driver circuit can detect a short circuit condition based upon a sensed voltage at the desaturation detection input. In another example, a method includes sensing a voltage on a blanking capacitor, the voltage provided from a sensing node of a composite switching device via a blocking diode and a resistor, and detecting a short circuit condition based upon the sensed voltage.
Various examples are provided related to access control of accelerators. In one example, a method for cryptographic memory management includes receiving, by a cryptographic memory management unit (CryptoMMU), a request identified as a private translation-lookaside buffer (TLB) miss or hit from an accelerator; in response to the TLB hit, generating a message authentication code (MAC); comparing the generated MAC to a MAC provided with the request; and in response to the comparison, allowing system memory access if the generated MAC matches the MAC provided with the request. In another example, a system can include a processing or computing device that can receive, by a CryptoMMU, a request identified as a private TLB miss or hit from an accelerator; generate a MAC in response to the TLB hit; compare the generated MAC to a MAC provided with the request; and allow system memory access in response to the comparison.
Various examples are provided related to fault detection of power converters. In one example, a method includes sensing phase currents of a three-phase transformer; determining a centroid vector in an alpha-beta stationary reference frame based upon averaged values of the sensed phase currents; identifying a fault on a side of the transformer based upon a location of the centroid vector within the alpha-beta stationary reference frame, the location defined by a magnitude and an angle of the centroid vector; and adjusting operation of the power converter in response to the identified fault. In another example, a power converter includes a three-phase transformer connected between primary and secondary side three-phase bridges and control circuitry that can determine a centroid vector based upon sensed phase currents; identify a fault on a side of the three-phase transformer; and adjust operation of the power converter in response to the identified fault.
H02M 1/32 - Means for protecting converters other than by automatic disconnection
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
96.
RECOMBINANT VIRAL EXPRESSION VECTORS AND METHODS OF USE
The present disclosure provides materials and methods relating to recombinant viral expression vectors. In particular, the present disclosure provides novel recombinant viral expression vectors comprising an RNA virus backbone that encodes a virus capable of infecting a target organism and expressing a polynucleotide-of-interest in that target organism. The novel viral vector constructs provided herein are a versatile expression tool for interrogating gene function and an efficient delivery platform for gene editing technology.
The present disclosure provides compositions and methods related to the purification and/or isolation of α-1 antitrypsin (AAT). In particular, the present disclosure provides novel peptide ligands capable of binding recombinantly produced α-1 antitrypsin to facilitate its isolation and/or purification from processing fluid streams for subsequent therapeutic use.
The University of North Carolina at Chapel Hill (USA)
North Carolina State University (USA)
Inventor
Hirsch, Matthew Louis
Song, Liujiang
Gilger, Brian Christopher
Abstract
This invention relates to vectors for delivery of ary lsulfatase B to the eye (e.g., cornea) of a subject and methods of using the same for treatment and pre-vention of corneal clouding and blindness in a subject due to mucopolysaccharidosis VI (MPS-VI) and other MPS VI-associated manifestations in the eye.
Various examples are provided related to dynamic nonlinear droop control (DNDC). In one embodiment, a method for DNDC for direct current (DC) power conversion includes receiving an indication of an output of a DC power converter, generating a control signal based upon the indication, and adjusting operation of the DC power converter in response to the generated control signal. The indication can be a scaled measurement of output current or output power of the DC power converter. The control signal is based at least in part upon the indication, the power converter voltage and DNDC parameters.
H02M 3/155 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
H02J 1/00 - Circuit arrangements for dc mains or dc distribution networks
100.
SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS
In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
patents
