The present disclosure provides compositions and methods related to the purification and/or isolation of antibodies. In particular, the present disclosure provides novel peptide ligands capable of targeting the fragment antigen binding (Fab) domain and/or single-chain variable fragment (scFv) of antibodies to facilitate the isolation and/or purification of antibodies from processing fluid streams. The novel ligands disclosed herein are capable of universal and subtype-specific biorecognition.
Disclosed herein are methods and compositions for detecting (+)-methamphetamine using dye-complexed and redox-tag-labeled aptamers that generate a detectable signal upon target binding.
In one aspect, the disclosure relates to precipitated hyperpolarized substrates, methods of making the same, contrast agents comprising the same, and methods of diagnosing and/or monitoring the progress of a disease using the same. In one aspect, the method comprises contacting a solution containing a first solvent and a hyperpolarized substrate with a non-polar organic solvent. In a further aspect, the precipitated hyperpolarized substrate can be separated from the first solvent, the non-polar organic solvent, or any combination thereof by filtration. In still another aspect, the method further includes redissolving the precipitated hyperpolarized substrate in a biocompatible solvent such as, for example, water or a physiologically-acceptable buffer. In any of these aspects, hyperpolarization of the substrate can be accomplished using Signal Amplification by Reversible Exchange (SABRE).
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
G01R 33/28 - Details of apparatus provided for in groups
4.
APPARATUS AND METHOD FOR IMPROVING YARN STRENGTH AND HAIRINESS IN SINGLES RING YARNS
The present invention provides a modified sustainable droplet-wet spinning technology aimed at enhancing hemp yarn quality. Implemented on a ring spinning machine, the technology delivers a controlled amount of water onto the top front roller which results in a more compact spinning triangle. The invention can be readily implemented on commercial ring spinning systems and improve both tenacity and hairiness of fibers comprising hemp.
This invention relates to molecular diagnostic tools for C. fimbriata to monitor and manage the pathogen in sweetpotato and other crop and forest systems where C. fimbriata can cause significant disease issues. Provided herein are methods to quickly detect and identify C. fimbriata in soil, wash water, diseased plants, or other complex samples.
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
Pursuant to embodiments of the present invention, a method of performing electronically controlled electrotherapy may include modifying or killing target cells and simultaneously modifying a secondary outcome by delivering electrical pulses and dynamically adjusting an energy delivery profile of the electrical pulses in response to a measurement. The secondary outcome may be a physical outcome, a biological outcome, and/or a systemic outcome.
The University of North Carolina at Chapel Hill (USA)
Inventor
Jiang, Xiaoning
Xu, Zhen
Zhang, Bohua
Wu, Huaiyu
Kim, Jinwook
Kim, Howuk
Dayton, Paul Alexander
Goel, Leela
Abstract
A method for sonothrombolysis mediated with contrast agents includes administering at least one contrast agent into a blood vessel of a patient. The method further includes controlling application of ultrasound energy to the at least one contrast agent within the blood vessel, wherein controlling the application of the ultrasound energy includes driving an ultrasound transducer with a signal having a first frequency component and a second frequency component different from the first frequency component.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
8.
METHODS TO RECONSTRUCT 3D IMAGE/MAP FOR THE STIFFNESS OF SOFT TISSUES
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
Guddati, Murthy
Elmeliegy, Abdelrahman
Urban, Matthew W.
Abstract
Various examples are provided related to methods and systems to reconstruct 3D image/map for the stiffness of soft tissues. In one example, a method includes obtaining particle velocities from generated mechanical waves in tissue of a subject; reconstructing a stiffness map of soft tissue in a region of interest (ROI) from the particle velocities; and generating an image of the stiffness map for rendering on a user device. In another example, a system includes an ultrasound scanner for shear wave elastography (SWE) and a computing or processing device that can obtain particle velocities; reconstruct a stiffness map of soft tissue in a ROI from the particle velocities; and generate an image of the stiffness map for rendering. The particle velocities can be generated from acoustic radiation forces produced by the ultrasound scanner.
The present disclosure provides materials and methods related to the purification of viral vectors. In particular, the present disclosure provides peptides, compositions, adsorbents, and related methods, capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from samples during the production and purification of lentivirus particles.
Provided are methods for detecting urogenital malignancies in dogs. In some embodiments, the methods include identifying a deletion or single nucleotide substitution within a BRAF gene and/or within a MAP2K1 gene present in or isolated from a biological sample from a. dog, wherein the presence of the deletion or single nucleotide substitution within the BRAF gene and/or within the MAP2K1 gene detects a urogenital malignancy, optionally transitional cell carcinoma/urothelial carcinoma, in the dog. In some embodiments, the deletion is within exon 12 of BRAF gene, optionally within the amino acid sequence KMLNVTAPTPQQL (SEQ ID NO: 3), and/or in within exon 2 or 3 of a M.AP2K1 gene, optionally within the amino acid sequence FLTQKQKVGE (SEQ ID NO: 4).
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
12.
METHODS, DEVICES, AND SYSTEMS FOR BIOMASS COMPOSTING AND CO2 CAPTURE
The present disclosure provides compositions, methods, devices, and systems related to biomass composting and carbon dioxide capture. In particular, the present disclosure provides compositions, methods, devices, and systems for the production of high purity carbon dioxide from a wide variety of biomass feedstock in a more efficient and cost-effective manner than conventional technologies.
C05F 17/10 - Addition or removal of substances other than water or air to or from the material during the treatment
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
This invention relates to recombinant Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) arrays and recombinant nucleic acid constructs encoding Type I-E CASCADE complexes, plasmids, retroviruses and bacteriophage comprising the same, and methods of use thereof for screening for variant cells of an organism.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Various examples are provided related to superfluorescence (SF) at room temperature. In one example, an upconversion nanoparticle (UCNP) includes a nanocrystal lattice doped with a rare earth element, the rare earth element distributed in the nanocrystal lattice with a coupling distance that produces anti-Stokes shifted SF. The rare earth element can be a Nd3+ ion.
‘NCORNSP-034SCVPG’ is a moderately compact, non-twining, semi-upright variety producing many short shoots. It is distinguishable from other cultivars on the market by its purple and green variegated cordate leaves. ‘NCORNSP-034SCVPG’ also exhibits good vigor and is well branched, a growth habit that promotes good plant production in the greenhouse for wholesale distributors. In greenhouse and field trials, ‘NCORNSP-034SCVPG’ has been shown to have stable variegation and is suitable for use as a landscape or containerized plant.
Various examples are provided related to gait kinematics. A methodology for human in the loop optimization (HILO) for use of a hip exoskeleton is presented. In one example, a method includes monitoring a gait phase of an exoskeleton and controlling switching time between admittance parameters associated with actuator control of the exoskeleton, where the switching time is controlled based upon the monitored gait phase. The admittance parameters can be predetermined and can be user specific. The time of the switching can be determined from use of the exoskeleton and can be determined using reinforcement learning.
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (USA)
Inventor
Roy, Tuhin
Guddati, Murthy
Urban, Matthew W.
Capron, Charles B.
Abstract
Various examples are provided related to estimation of viscoelasticity of an arterial or venous wall. In one example, a method includes obtaining ultrasound data of an arterial or venous wall for a defined acoustic radiation force; and determining viscoelasticity of the arterial or venous wall. The viscoelasticity can be determined based upon correlation between measured and simulated wall velocity of the ultrasound data in a space-time, a wavenumber-frequency, wavenumber-time, or space-frequency domain; or in a sequential manner by determining the elastic part of the modulus by matching measured and simulated phase velocities and determining the viscoelasticity part by matching measured and simulated wall velocities; or a combination of both. The simulated velocity can be determined for a wall thickness and viscoelastic modulus of the arterial or venous wall through full wave analysis. In another example, a system includes an ultrasound scanner and a computing device that can implement the method.
Various examples are provided related to diversity based deep learning. In one example, a learned diversity neural network (LDNN) system includes an input layer; an output layer; and at least one hidden layer including at least one activation function neuronal network. The at least one activation function neuronal network includes an input node, an output node, and a plurality of intermediate nodes coupled between the input and output nodes and isolated from other nodes or other activation function neuronal networks of the at least one hidden layer.
Methods of preparing melt-spun polyacrylonitrile (PAN) fibers are described. The fibers can be used as carbon fiber precursors and/or carbonized and graphitized to provide carbon fibers. The methods can include melt-spinning mixtures of PAN and a meltable solvent, such as dimethyl sulfone. In some methods, the mixtures also include lignin and/or can include waste PAN or PAN copolymers prepared from bio-derived monomers. Carbon fibers and carbon fiber composites prepared from the melt-spun fibers are also described.
D01F 6/38 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from copolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds comprising unsaturated nitriles as the major constituent
D01F 9/00 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments
D01F 9/17 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from products of vegetable origin or derivatives thereof, e.g. from cellulose acetat from lignin
D01F 9/22 - Carbon filamentsApparatus specially adapted for the manufacture thereof by decomposition of organic filaments from polyaddition, polycondensation or polymerisation products from macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from polyacrylonitriles
24.
PACKAGING COATINGS, PACKAGING PRODUCTS, AND METHODS OF MAKING
Provided are barrier films, packaging products including barrier films, and methods of making paper/packaging products including barrier films. The barrier films can have antimicrobial properties and can include nanofibrillated cellulose treated with hemp extractives. The nanofibrillated cellulose can be obtained from autohydrolysed hemp pulp. The antimicrobial packaging products or paper products can be made by obtaining pulp fibers from autohydrolyzed hemp hurds, mechanically grinding the pulp fibers to obtain nanofibrillated cellulose, solvent casting the nanofibrillated cellulose films in an aqueous system, treating the nanofibrillated cellulose films with hemp extractives, and applying the hemp extractive treated films to a substrate.
B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor
B29K 1/00 - Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
B32B 9/02 - Layered products essentially comprising a particular substance not covered by groups comprising animal or vegetable substances
B32B 9/06 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance of paper or cardboard
B65D 65/42 - Applications of coated or impregnated materials
25.
4-PHENYL-2-PYRROLIDINONES AND METHODS OF USING THEREOF
Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/12 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
Disclosed is a composition comprising (a) a lignocellulosic material and/or a cellulosic material; and (b) a cellulose derivative. A process for preparing the composition is also disclosed. The process can comprise providing a cellulose derivative in a solvent; and mixing a lignocellulosic material and/or a cellulosic material into the solvent. The lignocellulosic material and/or the cellulosic material can comprise 90% of particles ranging from 0.01 to 5 mm in size. The lignocellulosic material and/or the cellulosic material can be derived from a biomass residue.
C08L 97/02 - Lignocellulosic material, e.g. wood, straw or bagasse
B33Y 70/00 - Materials specially adapted for additive manufacturing
C08J 3/00 - Processes of treating or compounding macromolecular substances
C08J 3/09 - Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
Compositions and methods for reducing the level of nornicotine and N′-nitrosonornicotine (NNN) in tobacco plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for a root-specific nicotine demethylases, CYP82E10, and variants thereof, that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Compositions of the invention also include tobacco plants, or plant parts thereof, comprising a mutation in a gene encoding a CYP82E10 nicotine demethylase, wherein the mutation results in reduced expression or function of the CYP82E10 nicotine demethylase. Seed of these tobacco plants, or progeny thereof, and tobacco products prepared from the tobacco plants of the invention, or from plant parts or progeny thereof, are also provided. Methods for reducing the level of nornicotine, or reducing the rate of conversion of nicotine to nornicotine, in a tobacco plant, or plant part thereof are also provided. The methods comprise introducing into the genome of a tobacco plant a mutation within at least one allele of each of at least three nicotine demethylase genes, wherein the mutation reduces expression of the nicotine demethylase gene, and wherein a first of these nicotine demethylase genes encodes a root-specific nicotine demethylase involved in the metabolic conversion of nicotine to nornicotine in a tobacco plant or a plant part thereof. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
C12Q 1/6895 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
28.
2,3-PYRROLIDINEDIONE CONJUGATES AND METHODS OF USING THEREOF
Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compounds can also exhibit activity against Gram negative biofilms. In some cases, the compounds can exhibit both biofilm modulation properties and antimicrobial activity. Compositions comprising these compounds, as well as methods of using thereof, are also described. For example, the compounds described herein can be used in human and animal health (e.g., for the treatment of infection), agriculture, marine coatings, and other coating applications related to prevention of biofilm (e.g., dental, medical, etc.).
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
Sustainable paper-based packaging materials, e.g., packaging materials comprising agro-based microfibrillated cellulose (A-MFC), are described. The packaging materials include coatings and films prepared from A-MFC derived from hemp hurds, cocoa pod husks, and other agro-residues or byproducts and having a high level of primary and/or secondary fines. Methods of preparing the A-MFC can involve a reduced amount of energy compared to wood-derived materials and the packaging materials can have enhanced barrier and mechanical properties, such as enhanced oil and grease resistance.
Various examples are provided related to soft crawling robots. In one example, a robot includes a bimorph structure including a liquid crystal elastomer (LCE) ribbon and a nanowire composite film; and electrical connections for coupling the nanowire network to a controlled low voltage source. The nanowire composite film includes a nanowire network forming conductive channels embedded below a surface of the nanowire composite film. Energizing a defined conductive channel can produce out-of-plane deformation in a portion of the bimorph structure to induce directional locomotion of the robot.
B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
B62D 29/04 - Superstructures characterised by material thereof predominantly of synthetic material
31.
PORPHYRIN-HYDROPORPHYRIN COMPOUNDS, COMPOSITIONS COMPRISING THE SAME AND METHODS OF USE THEREOF
Described herein are compounds that include a first porphyrin; and a first hydroporphyrin, wherein the first porphyrin is attached to the first hydroporphyrin. The compound may be a luminescent compound (e.g., a fluorescent compound). Also provided are particles and compositions including compounds described herein. Further provided are methods of making and using the particles and methods of making the same.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
The use of nonanal and similar aldehydes as an insect attractant is described. For example, compositions and methods for attracting and/or trapping insects involving the use of two active components. one including a C7-C11 aldehyde, e.g., nonanal, and a second including an aggregation pheromone, a kairomone, a food, and/or a fermentation-based attractant are described. In addition, methods and compositions for attracting male insects of the genus Helicoverpa, Chloridea, or Heliothis using a C7-C11 aldehyde and/or 1-hexanol, along with another sex pheromone component, are described.
A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
‘NCORNSP-033SCMP’ is a compact, non-twining, semi-upright variety producing many short shoots. It is distinguishable from other cultivars by its palmate, deeply lobed leaves with 7-9 lobes, a compact habit, and semi-erect mounding plant architecture. The purple leaves, deep-lobing, quantity of lobes, short internodes, and the plant architecture distinguishes ‘NCORNSP-033SCMP’ amongst the current ornamental sweetpotatoes in the marketplace. ‘NCORNSP-033SCMP’ also exhibits good vigor and is very well branched, a growth habit that promotes good plant production in the greenhouse for wholesale distributors. In greenhouse and field trials, ‘NCORNSP-033SCMP’ has been shown to be suitable for use as a landscape or containerized plant.
The present invention relates to vortex ultrasound transducers and methods of therapeutic ultrasound treatment. A device for therapeutic ultrasound treatment includes a jacket for insertion within a blood vessel of a patient and an ultrasound transducer located within the jacket and comprising a plurality of active elements that are arranged such that, when activated, the ultrasound transducer is configured to generate ultrasound energy with a swirling movement that produces a mechanical shear stress over a target area within the blood vessel of the patient.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
Various examples are provided related to a cardiac valve repair device. In one example, the device includes an outer structure with outer blocks, and inner blocks. Each outer block can include an outer magnet pack disposed within in outer block void, at least one tension wire channel extending through the outer block between a first end and a second end and along the outer block void, a connection point on each of the first end and the second end, and attachment openings on each of a first side and a second side extending between the first end and the second end. The outer structure can also include tension wires extending through corresponding tension wire channels and connectors that can couple the outer blocks. Each inner block includes an inner magnet pack disposed within an inner block void and attachment openings that correspond to the attachment openings of the outer blocks.
A hyperpolarization system including a solution and at least one magnetic field controller. The solution includes at least parahydrogen, a polarization transfer complex (PTC), and substrate molecules. The at least one magnetic field controller is configured to apply a static ultra-low magnetic field to the solution and apply an alternating ultra-low magnetic field to the solution. Through application of the ultra-low magnetic fields to the solution, the system hyperpolarizes at least some of the substrate molecules.
The present disclosure provides materials and methods related to the production of peptides and polypeptides from engineered microorganisms. In particular, the present disclosure provides compositions and methods for producing a genetically modified microorganism (e.g., yeast cell) with enhanced protein expression and/or secretion.
In one aspect, the disclosure relates to a method for hyperpolarizing the long-lived singlet state of 13C2 pyruvate with parahydrogen and transferring the polarization to methyl pyruvate protons for detection, or to protons in other target analytes having a long-lived hyperpolarized singlet state and protons weakly couple into the singlet spin pair. In a further aspect, the method can be conducted on conventional, proton-only MRI systems. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
The invention relates to textile fibres, and particularly, although not exclusively, to textile microfibres and/or textile nanofibres, and their conversion into carbon nanomaterials. The invention extends to methods for converting non-biodegradable textile micro- and nanofibres and micro- and nanoplastics into harmless, non-toxic and/or biodegradable/biocompatible end-products, and encompasses apparatus and/or reactors used to perform these methods.
The present disclosure provides materials and methods related to gene stacking. In particular, the present disclosure provides gene stacking systems and components thereof and methods for delivering target DNA inserts to acceptor vectors and target cells such as plant cells. The provided gene stacking systems and components thereof enable an increased DNA cargo size limit, such as an acceptor vector configured to contain up to 300 kb of target DNA inserts. The provided gene stacking systems and components thereof also enable editing of constructs post-assembly. Additionally, the provided gene stacking systems are compatible with all major Type IIS cloning technologies in plants.
The present disclosure provides compositions and methods related to the delivery of therapeutic medicines to the heart for treating a cardiac injury, such as those that occur due to a myocardial infarction (MI). In particular, the present disclosure provides novel hydrogel-based compositions that safely and effectively deliver a therapeutic agent to the pericardial cavity of the heart to treat the cardiac injury.
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
44.
COMPOSITIONS AND METHODS RELATED TO EXTRACELLULAR VESICLE THERAPEUTIC DELIVERY PLATFORM
The present disclosure provides compositions and methods related to engineered extracellular vesicles (EVs). In particular, the present disclosure provides a novel delivery platform for administering therapeutic agents to a subject using engineered EVs. As provided herein, EVs can be used to deliver biologically active cargo (e.g., mRNA, tumor antigens, small molecule drugs) to a subject to treat and/or prevent disease (e.g., viral infection, cancer, etc.).
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
45.
METHODS FOR PREPARING AND USING AT LEAST ONE PROTECTIVE COATING ON INDUSTRIAL COMPONENTS AND STORAGE SYSTEMS
Methods for preparing and using at least one protective coating on industrial articles and storage systems are disclosed. In one example, the industrial components are dry storage cannisters for spent nuclear fuel or other waste materials. An example method for preparing at least one protective coating on dry storage cannisters for spent nuclear fuel and waste includes dissolving a dispersant in an organic solvent. The method further includes adding a polymer-derived ceramic (PDC) to the organic solvent and dissolved dispersant to create a pre-ceramic solution. The method further includes applying the pre-ceramic solution on a metal and/or alloy of industrial articles and storage systems such as the dry storage cannisters.
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
Methods of preparing fibers comprising cellulose esters are described. The fibers include bicomponent core-sheath fibers where the core comprises one or more cellulose esters and the sheath comprises a polyolefin prepared by co-extrusion of mixtures comprising a cellulose ester and mixtures comprising a polyolefin, as well as substantially solid body fibers prepared by melt-spinning a mixture comprising one or more cellulose ester and a meltable solvent. Also described are fibers comprising cellulose esters, e.g., the fibers prepared by the disclosed methods, and related articles, such as textiles, clothing, synthetic fibers, and faux fur. The fibers can include colorants (e.g., colorants derived from natural materials) and/or flame retardants.
D01F 8/02 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from cellulose, cellulose derivatives, or proteins
D01F 1/07 - Addition of substances to the spinning solution or to the melt for making fire- or flame-proof filaments
D01F 8/06 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyolefin as constituent
D02G 3/02 - Yarns or threads characterised by the material or by the materials from which they are made
D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed
D03D 15/225 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads cellulose-based artificial, e.g. viscose
D03D 15/283 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads synthetic polymer-based, e.g. polyamide or polyester fibres
D03D 15/292 - Conjugate, i.e. bi- or multicomponent, fibres or filaments
D03D 15/513 - Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads heat-resistant or fireproof
47.
REDOX CATALYSTS AND PROCESSES FOR EFFICIENT OXIDATIVE DEHYDROGENATION OF ALKYLAROMATICS
The present invention provides novel redox catalysts and processes using the redox catalyst for the oxidative dehydrogenation of alkylaromatics. The catalyst enables the dehydrogenation reaction to produce an alkenylaromatic and hydrogen, the selective hydrogen combustion reaction of lattice oxygen with the hydrogen to produce steam, and carbon monoxide/dioxide (COx) management by mitigating COx production, capturing the COx, and/or or otherwise providing COx resistance.
C07C 5/32 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by dehydrogenation with formation of free hydrogen
B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
B01J 23/78 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with alkali- or alkaline earth metals or beryllium
B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
In various exemplary embodiments, the present disclosure provides novel water-absorbent textile-based gas-liquid-solid contactors for carbon dioxide (CO2) gas separation, as well as novel methods for producing and using these materials. The water-absorbent textile-based contactors of the present invention allow aqueous liquids to penetrate and travel intimately throughout the water-absorbent textile structure. The textile structure comprises many fibers with small diameters which creates a very high surface area. When exposed to a gas, the gas will be in contact with liquid spread throughout the solid wetted textile structure, all three phases “gas-liquid-solid” are in intimate contact. The textile contactor itself has superior performance compared to conventional packing materials, and, when combined with biocatalysts, the performance improves even more dramatically. By incorporating a biocatalyst, the invention enables use of benign solvents that have otherwise been overlooked in conventional systems due to poor kinetics.
Various examples are provided related to physically-timed keys. In one example, a method to provide a physically-timed physical unclonable function key includes providing a grid of metastable metal particles on undercooled metal particles; and inducing particle coalescence and growth of individual metastable metal particles through photon stimulation thereby forming a point-based pattern in the grid of metastable metal particles. Each point in the grid of metastable metal particles can carry predefined information or bear a specified information density. The method can further include initiating a physical timer of the grid of metastable metal particles by application of an external mechanical perturbation thereby triggering a phase relaxation of the individual metastable metal particles.
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
B23K 26/352 - Working by laser beam, e.g. welding, cutting or boring for surface treatment
A device for therapeutic ablative treatment of residual plaque on, in, and/or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and/or axial direction of the jacket from within the stent to ablate the residual plaque.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 17/00 - Surgical instruments, devices or methods
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Methods of preparing mono- and multi-component fibers comprising polylactic acid (PLA) are described. Exemplary fibers include co-extruded bicomponent core-sheath fibers where the core includes PLA and the sheath includes polyolefin. The fibers can include various colorants, such as colorants derived from natural materials and/or flame retardants. Also described are fibers comprising PLA, e.g., the fibers prepared by the disclosed methods, and related articles, such as textiles, clothing, synthetic fibers, and faux fur.
D01F 8/14 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyester as constituent
D01F 1/07 - Addition of substances to the spinning solution or to the melt for making fire- or flame-proof filaments
D01F 6/62 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyesters
D01F 8/06 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyolefin as constituent
52.
COMPOSITIONS AND METHODS FOR PURIFYING BIOLOGICAL FLUIDS
The present disclosure provides materials and methods related to the purification of a biologic from a biological fluid. In particular, the present disclosure provides compositions, and related methods, comprising peptide ligands capable of removing process-related impurities (e.g., host cell proteins, nucleic acids, and media components) and product-related impurities (e.g., product fragments, product aggregates, and inactive forms derived from product degradation by or association with other species in the cell culture harvest) from biological fluids during the production of a biologic.
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 5/107 - Tetrapeptides the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
C07K 5/11 - Tetrapeptides the side chain of the first amino acid containing more amino groups than carboxyl groups, or derivatives thereof, e.g. Lys, Arg
C07K 5/113 - Tetrapeptides the side chain of the first amino acid containing more carboxyl groups than amino groups, or derivatives thereof, e.g. Asp, Glu, Asn
C07K 5/117 - Tetrapeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp
A novel localized, mechanical HIFU (LM-HIFU) transcatheter device that can ablate cancer cells and disrupt the stromal barrier in tumors, enhancing the efficacy of therapeutics and increasing immune cell infiltration. A miniaturized dual-lumen catheter device is configured to deliver M-HIFU to a tumor that does not have the anatomic limitations of conventional HIFU, and enables access to a primary or metastatic tumor regardless of the location.
Disclosed herein are colloidal mixtures including fibrin nanoparticles. The mixtures are useful to treat wounds and promote healing. The mixtures can also include a blood co-factor, thrombin, and a calcium salt.
The present disclosure provides vaccine compositions, kits, and/or vectors for preventing, decreasing, reducing, and/or ameliorating spread of bacterial pathogens causing Clostridial dermatitis/Gangrenous dermatitis/Cellulitis in poultry animals, and methods of use thereof.
The present invention relates to modifications of berberine bridge enzyme-like nucleic acids and their use in modulation of nicotine biosynthesis in plants.
The present disclosure provides compositions and methods related to tobacco plants. In particular, the present disclosure provides novel methods for producing tobacco plants, and any related tobacco products, having low nicotinic alkaloid content. Tobacco plants produced according to the methods of the present disclosure exhibit reduced levels of nicotinic alkaloids (e.g., nicotine) compared to both naturally-occurring and transgenic tobacco plants, and thus represent a commercially valuable alternative to currently available tobacco varieties.
Disclosed herein is a novel Cas9 protein. Further described herein are fusion proteins, compositions, and methods comprising the same. The novel Cas9 protein may be used, for example, in compositions and methods for modulating expression of a gene, for correcting a mutant gene, and for treating a disease.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
C12N 15/90 - Stable introduction of foreign DNA into chromosome
60.
Side-Channel Aware Training for Commercial Machine Learning Accelerators
Various examples are provided related to side-channel awareness. In one example, a method for side-channel awareness training includes generating trained models by stochastically training neural network models using a common training dataset; generating an inference model based upon random selection of parameters from one or more of the trained models; and training the inference model with the selected parameters. The trained inference model can be executed on an edge Tensor Processing Unit (TPU). The models can be trained offline. An input signal can be processed using the trained inference model to generate an output signal for transmission.
The present technology provides methods of combining mutations in N-methylputrescine oxidase (MPO) gene isoforms with mutations in the three major berberine bridge enzyme-like (BBL) genes to produce low-nicotine tobacco plants and which prevent the accumulation of anatabine in the tobacco plants. Also provided are methods of combining these mutations to produce tobacco plants, tobacco cells, and tobacco products having reduced nicotine content and which avoid the unwanted consequence of elevated anatabine levels in the tobacco plants, cells, and products.
A system, method, and device for retaining an implanted medical device is disclosed, the device including: a sleeve body extending circumferentially around a first longitudinal axis. The sleeve body defines a first aperture on a first end of the sleeve body and a second aperture on a second end of the sleeve body. The second end is spaced apart longitudinally from the first end of the sleeve body. The device further includes a sheath coupled to an inner surface of the sleeve body and extending circumferentially around a second longitudinal axis. The sheath defines a third aperture on a first end of the sheath and a fourth aperture on a second end of the sheath. The second end of the sheath is spaced apart from the first end of the sheath.
A polymer solar cell ink for organic solar cell (OSC) devices is provided. The polymer solar cell ink includes at least one solid state additive. The polymer solar cell ink further includes a donor polymer. The polymer solar cell ink further includes a nonfullerene acceptor (NFA).
The present disclosure relates to a photoreactor and method of use thereof. In an aspect, the photoreactor can be configured as a solar panel comprising a channel containing a heterogeneous photocatalyst. When water or another hydrogen-containing liquid is pumped through the photoreactor, it contacts the photocatalyst in the presence of UV or visible irradiation, simultaneously releasing hydrogen and separating the hydrogen via a gas-permeable membrane. In an aspect, the photoreactor can be used in a method for continuous production of high-purity H2 gas, the method comprising dehydrogenating tetrahydroquinoline (THQ) to form quinoline under visible light using a Rh/TiO2 heterogeneous photocatalyst. In another aspect, the catalyst includes Rh particles photodeposited on TiO2 microparticles. In a further aspect, the method can include regenerating THQ from quinoline using a water gas shift (WGS) reaction.
B01J 19/12 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing electromagnetic waves
B01J 8/06 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds in tube reactorsChemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds the solid particles being arranged in tubes
B01J 19/24 - Stationary reactors without moving elements inside
C01B 3/26 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds of hydrocarbons using catalysts
67.
COMPOSITIONS AND METHODS RELATED TO SOMATIC EMBRYOGENESIS IN ROSE PLANTS
The present disclosure provides compositions and methods for producing a rose plant using somatic embryogenesis. In particular, the present disclosure provides novel methods and media for rose callus induction, embryoid suspension, and embryo regeneration. Unlike currently available techniques, the novel compositions and methods provided herein produce high yields of competent cells and high frequencies of rose somatic embryogenesis.
The present disclosure provides compositions and methods related to the culturing of trophoblast stem cells (TSCs). In particular, the present disclosure provides novel formulations and methods for inducing and maintaining trophoblast stem cells obtained from cytotrophoblasts (CTBs) obtained from a placenta at birth. The compositions and methods described herein allow for the development of in vitro models of early human placental development and establish a platform for therapeutic discoveries.
The present disclosure provides materials and methods related to increasing viral resistance of plants. In particular, the present disclosure provides antiviral hairpin constructs having a stem region, wherein the stem region includes one or more polynucleotide sequences, wherein each of the one or more polynucleotide sequences individually have at least 70% identity or complementarity to a sequence from a target virus. Also provided are methods of increasing virus resistance or preventing viral infection in a plant comprising providing an antiviral hairpin construct or a nucleic acid encoding an antiviral hairpin construct to the plant.
‘NCCH3’ is a new cultivar of flowering dogwood with a unique combination of traits including large white bracts, large glossy leaves, a fast growth rate, and showy fall color.
The present disclosure provides compositions and methods related to opioid detection. In particular, the present disclosure provides aptamer-based colorimetric assays for the visualization and identification of specific opioids (natural, semi-synthetic, synthetic and the derivatives and analogs thereof) in a manner that is rapid, specific, and sensitive.
A wearable ultrasound device may include an array of ultrasound transducers, wherein each ultrasound transducer comprises: a matching layer on a top side, an active layer adjacent the matching layer, a first backing layer adjacent the active layer, a second backing layer adjacent the first backing layer; and an epoxy bonding material interspaced between each of the matching layer, the active layer, the first backing layer, and the second backing layer, wherein the array of ultrasound transducers is surrounded by a PDMS filling, whereby the active layer is configured to communicate a signal in response to mechanical deformation.
Various examples are provided related to ceramic substrate windings and their application. In one example, a ceramic substrate coil includes a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate, the at least one coil trace forming at least a partial loop about the ceramic substrate surface. In another example, a permanent magnet machine includes a rotor and a stator including ceramic coils. Each of the ceramic coils include a ceramic substrate and at least one coil trace disposed on a first surface of the ceramic substrate. The ceramic coils are positioned, and the coil traces are connected to form a stator winding of the permanent magnet machine.
H02K 3/26 - Windings characterised by the conductor shape, form or construction, e.g. with bar conductors consisting of printed conductors
H02K 1/12 - Stationary parts of the magnetic circuit
H02K 3/02 - Windings characterised by the conductor material
H02K 9/19 - Arrangements for cooling or ventilating for machines with closed casing and closed-circuit cooling using a liquid cooling medium, e.g. oil
H02K 9/22 - Arrangements for cooling or ventilating by solid heat conducting material embedded in, or arranged in contact with, the stator or rotor, e.g. heat bridges
74.
ATOMIC LAYER ETCHING OF METALS USING NOVEL CO-REACTANTS AS HALOGENATING AGENTS
The disclosed and claimed subject matter relates to thermal atomic layer etch (ALE) processing of metals and alloys thereof (e.g., cobalt and cobalt alloys) using thionyl chloride (SOCl2) or a combination of thionyl chloride and pyridine.
The present disclosure is directed to a multi-variant control system for an industrial facility. In one form of a method, a processor monitors a behavior of a distributed control system with respect to at least a set of uncontrolled variables, a set of controlled variables, and a set of monitored variables; trains a model based on the monitored behavior utilizing at least one of artificial intelligence or machine learning; and identifies, based on the model, a subset of controlled variables for optimization. Further, the processor monitors a behavior of the industrial facility without the use of the distributed control system; optimizes, based on the monitored behavior, the subset of controlled variables to obtain a target result and restrict variation of values of the set of monitored values; and executes a control system for the industrial facility based on the optimization of the subset of controlled variables.
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
G05B 13/02 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
76.
CHROMATOGRAPHY MEDIUM FOR PURIFYING TARGET BIOLOGICS
The present disclosure provides materials and methods related to the purification of a biologic. The present disclosure provides materials and methods related to the purification of a biologic. In particular, the present disclosure provides a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.
C07K 1/16 - ExtractionSeparationPurification by chromatography
B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
78.
POLYMERIC FLUOROPHORES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF PREPARING AND USING THE SAME
Described herein are polymeric fluorophores that include a dye, a polymer, and optionally a bioconjugate group. A polymeric fluorophore may have a structure represented by: A-B-C or C-A-B, wherein A is a dye; B is a polymer comprising one or more hydrophobic unit(s) and one or more hydrophilic unit(s); and optionally C, wherein C, when present, comprises a bioconjugate group. Also described herein are compositions comprising the polymeric fluorophores and methods of preparing and using the same.
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
79.
PARALLELING POWER SEMICONDUCTORS WITH DIFFERENT SWITCHING FREQUENCIES
Various examples are provided related to operation of parallel semiconductors with different switching frequencies. In one example, a method of reducing conduction and switching losses in a high current switching circuit includes controlling two hybrid switches to conduct concurrently or alternately, each of the hybrid switches include a wide bandgap device and a silicon power device. Controlling of the silicon power device is at a first gate switching frequency and controlling of the wide bandgap device is at a second gate switching frequency, where the first gate switching frequency is lower than the second gate switching frequency. The silicon power device can be switched at a frequency of about 50 or 60 Hertz. The wide bandgap device can be switched at a frequency greater than 1 kHz.
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
A cargo container system, comprising: a vehicle with a cargo compartment; a cargo container configured to fit within the cargo compartment; and, a weight balance adjustment mechanism, comprising at least one of a load sensor and a position sensor, configured to adjust the position of the cargo container within the cargo compartment using data received from the at least one of a load sensor and a position sensor
G05D 3/20 - Control of position or direction using feedback using a digital comparing device
B62D 33/10 - Superstructures for load-carrying vehicles characterised by the connection of the superstructure to the vehicle frame comprising means for the suspension of the superstructure on the frame
B64D 9/00 - Equipment for handling freightEquipment for facilitating passenger embarkation or the like
B65D 88/14 - Large containers rigid specially adapted for transport by air
81.
METHODS FOR MANUFACTURING METAL OXIDE INFUSED CONFORMAL COATING MATERIAL AND METAL OXIDE INFUSED CONFORMAL COATING MATERIAL MADE USING SAME
A method for manufacturing and applying a metal oxide coating for shielding an object from particle radiation includes heating a quantity of a resin of a polyurethane system and mixing a metal oxide with the quantity of the resin of the polyurethane system to form a mixture. The method further includes mixing a quantity of a hardener of the polyurethane system with the mixture to form a metal oxide infused conformal coating (MOICC). The method further includes applying the MOICC to an object to shield the object from particle radiation and curing the MOICC.
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
Inventor
Jiang, Xiaoning
Kim, Jinwook
Ma, Jianguo
Dai, Xuming
Abstract
A catheter-implemented transducer device for intravascular thrombolysis, is described herein. Such a transducer device includes a catheter defining a longitudinal axis and having opposed proximal and distal ends. At least one ultrasonic transducer arrangement is disposed about the distal end. The ultrasonic transducer arrangement is oriented with acoustic waves propagating parallel or perpendicular to the longitudinal axis. Optionally, the ultrasonic transducer arrangement is configured as a multi-layer stacked structure of ultrasonic transducer elements. Optionally, the ultrasonic transducer arrangement is a laser ultrasonic transducer arrangement. Optionally, the ultrasonic transducer arrangement is configured to operate in a lateral mode.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
A61B 18/26 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor for producing a shock wave, e.g. laser lithotripsy
83.
GENETIC APPROACH FOR ACHIEVING ULTRA LOW NICOTINE CONTENT IN TOBACCO
The present invention relates to tobacco products from plants comprising mutated berberine bridge enzyme-like nucleic acids and the recessive nic1 and/or nic2 alleles and methods of making the same.
Systems and methods for monitoring sleep are disclosed. According to an aspect, a method includes emitting light into tissue. The method also includes detecting light backscattered from the tissue. Further, the method includes determining a sleep pattern based on the backscattered light.
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
86.
BIOSENSOR AND METHODS OF IN-SITU MEASURING OF NUTRIENT CONTENT OF A CROP CULTIVATION SUBSTRATE
The subject matter described herein is directed to systems, detection devices and enzyme sensors for real-time determination of the concentration levels of nutrients in a crop cultivation substrate using thermal signals and change in enthalpy per unit of enzyme. Methods of using the systems, detection devices and enzyme sensors for agricultural applications are described.
C12N 11/14 - Enzymes or microbial cells immobilised on or in an inorganic carrier
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01K 7/02 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using thermoelectric elements, e.g. thermocouples
G01K 7/16 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements
87.
HYDROFORMYLATION PROCESS FOR PREPARING LINEAR AND BRANCHED ALDEHYDES
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
Described are processes for preparing linear and branched aldehydes, which comprises reacting an olefin with hydrogen and carbon monoxide in the presence of a catalyst solution comprising rhodium, a hydroformylation solvent, and a fluorophosphite ligand having the general formula (I).
C07C 45/50 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
B01J 23/46 - Ruthenium, rhodium, osmium or iridium
The present disclosure provides components and systems for targeted protein degradation in cells (e.g., in plant cells). In particular, the present disclosure provides a protein containing the Leucine-Rich Repeat (LRR) and novel E3 ligase (NEL) domains of SspH1 for use with Homology Region 1b (HR1b) domain of human PKN1 for degrading target proteins.
The present disclosure provides compositions, methods, and systems related to a dual-affinity ratiometric quenching bioassay. In particular, the present disclosure provides novel compositions and methods that combine selective biorecognition and quenching of fluoescence signals for rapid and sensitive quantification of proteins in complex samples.
G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
90.
SEQUENCING AND STRATEGIES FOR ENHANCING INTRAVASCULAR THROMBUS DISRUPTION WITH PHASE-CHANGE CAVITATION ENHANCING AGENTS
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (USA)
THE REGENTS OF THE UNIVERSITY OF MICHIGAN (USA)
Inventor
Dayton, Paul Alexander
Kim, Jinwook
Jiang, Xiaoning
Zhang, Bohua
Wu, Huaiyu
Xu, Zhen
Abstract
A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
In one aspect, the disclosure relates to compositions including a collagen hydrogel and a flavonoid, wherein at least a portion of the collagen hydrogel is crosslinked by the flavonoid, methods of making the cosmetic and pharmaceutical compositions comprising the same, and methods of healing wounds using the same. The disclosed compositions are cytocompatible and can protect cells from oxidative damage through preventing damage from and/or reducing accumulation of reactive oxygen species (ROS). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Compounds comprising a tetrapyrrole macrocycle that includes a radionuclide; a hydrogelator attached to the tetrapyrrole macrocycle; a water solubilizing group attached to the hydrogelator; and a cleavage site that is between the hydrogelator and the water solubilizing group are described herein along with their methods of use. Two or more compounds of the present invention may two or more compounds may self-assemble (e.g., aggregate), optionally in vivo.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
93.
ENCAPSULATION OF NUTRITIONAL AND/OR COMPOUNDS FOR CONTROLLED RELEASE AND ENHANCING THEIR BIOAVAILABILITY BY LIMITING CHEMICAL OR MICROBIAL EXPOSURE
The present invention provides methods for recovering metals, including rare earth metals, from mixed metals. An example is the recovery of metals from electronic waste. The method of separation is based on the inversion and/or lowering of the thermodynamic energy barrier by using one or more stressors applied at appropriate ratios to create lower energy points in the thermodynamic energy landscape of the mixed metals. Example stressors include a) a chemical stress, b) a mechanical stress, c) a thermal stress, d) and electromagnetic radiation and/or light stress, an interfacial stress, and/or a magnetic flux gradient stress.
A non-shedding hybrid nonwoven web comprised of 99% by mass of functional material(s) co-mingled with the filaments. High level of particle retention within the fabric is provided without the aid of adhesives, binders, adhesive polymers, or post processes. This composite web has a multi-layered structure with a uniform distribution of sorptive particles and desired opposed color contrast on each side. The process includes providing two converging streams of blown polymeric filaments, passive feed of functional material(s) in between the filament streams, and collecting the hybrid webs.
D04H 1/407 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing absorbing substances, e.g. activated carbon
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
D04H 1/56 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving in association with fibre formation, e.g. immediately following extrusion of staple fibres
D04H 3/16 - Non woven fabrics formed wholly or mainly of yarns or like filamentary material of substantial length characterised by the method of strengthening or consolidating with bonds between thermoplastic yarns or filaments produced by welding with bonds between thermoplastic filaments produced in association with filament formation, e.g. immediately following extrusion
Methods of mineralizing hemp fiber to provide hemp fibers mineralized with calcium carbonate are described. Also described are mineralized hemp fibers and compositions including the mineralized hemp fibers. The mineralized hemp fibers can be hemp fibers with calcium carbonated deposited on the hemp fiber surface. The compositions including the mineralized hemp fibers can be cementitious or non-cementitious. Also described are methods of preparing “green” concrete comprising mineralized hemp.
The loss of cross-linking abilities in highly substituted alginate scaffolds is a significant problem affecting the use of alginate polymers in implants, cell delivery, and tissue engineering. Disclosed are modified alginate scaffolds that retain their gelation properties under high chemical modification, as well as methods of making and using thereof.
Screw dislocations play a significant role in the growth of crystalline structures by providing a continuous source of surface steps, which represent available sites for crystal growth. Here we show that pure screw dislocations can become helical by the absorption of defects (e.g., vacancies), and develop attractive interaction with another helical dislocation to form a double helix of screw dislocations. These single and double helix of screw dislocations can result in the formation of interesting nanostructures with large Eshelby twists. Examples of the formation of a double helix during thermal annealing of screw dislocations in magnesium oxide are presented. These large effective Burgers also unravel the mechanism for the formation of nanopipes and micropipes with hollow cores and nanotubes with Eshelby twists in technologically important materials, such as SiC, GaN and ZnO that are utilized in a variety of advanced solid state devices.
patents
