LIPID NANOPARTICLES FOR DELIVERING NUCLEIC ACID TO PERIPHERAL BLOOD MONONUCLEAR CELLS, AND METHOD FOR DELIVERING NUCLEIC ACID TO PERIPHERAL BLOOD MONONUCLEAR CELLS USING SAME
National University Corporation Chiba Unversity (Japan)
Inventor
Nakai, Yuta
Tange, Kota
Akita, Hidetaka
Tanaka, Hiroki
Sakurai, Yu
Miyama, Ryo
Abstract
The present invention provides lipid nanoparticles for delivering nucleic acid to peripheral blood mononuclear cells that can improve the efficiency of nucleic acid delivery to peripheral blood mononuclear cells, and a method for delivering nucleic acid to peripheral blood mononuclear cells by using same. Lipid nanoparticles for use in delivering a nucleic acid to a peripheral blood mononuclear cell, containing an ionic lipid represented by the formula (1), a phospholipid that is 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups have not less than 20 carbon atoms and at least one of the acyl groups is an alkenoyl group, cholesterol, and a dimyristoylglycerol PEG represented by the formula: CH2(OR6)—CH(OR7)—CH2(OR8) (symbols in the formula are as described in the specification), and a method for delivering a nucleic acids to a peripheral blood mononuclear cell by using same.
The present invention provides lipid nanoparticles for delivering nucleic acid to peripheral blood mononuclear cells that can improve the efficiency of nucleic acid delivery to peripheral blood mononuclear cells, and a method for delivering nucleic acid to peripheral blood mononuclear cells by using same. Lipid nanoparticles for use in delivering a nucleic acid to a peripheral blood mononuclear cell, containing an ionic lipid represented by the formula (1), a phospholipid that is 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups have not less than 20 carbon atoms and at least one of the acyl groups is an alkenoyl group, cholesterol, and a dimyristoylglycerol PEG represented by the formula: CH2(OR6)—CH(OR7)—CH2(OR8) (symbols in the formula are as described in the specification), and a method for delivering a nucleic acids to a peripheral blood mononuclear cell by using same.
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
2.
METHOD FOR PRODUCING POLYOXYETHYLENE DERIVATIVE, METHOD FOR QUANTITATING POLYOXYETHYLENE COMPOUND, AND LABELING REAGENT FOR ANALYSIS USE
A method for producing a high molecular weight polyoxyethylene derivative having a derivatized hydroxyl group is disclosed. The method includes labeling an unreacted high molecular weight polyoxyethylene compound having a hydroxy group using a labeling reagent in a deuterated solvent, and quantitating a labeled solution by a pre-saturation method and a proton nuclear magnetic resonance spectroscopy using inverse gated decoupling. The method allows a prompt quantitation of unreacted high molecular weight polyoxyethylene compound having a hydroxy group with a high accuracy.
C08G 65/332 - Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides or esters thereof
C08G 65/331 - Polymers modified by chemical after-treatment with organic compounds containing oxygen
C08G 65/333 - Polymers modified by chemical after-treatment with organic compounds containing nitrogen
C08G 65/334 - Polymers modified by chemical after-treatment with organic compounds containing sulfur
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
3.
METHOD FOR PRODUCING ACTIVE CARBONIC ACID ESTER OF POLYETHYLENE GLYCOL, AND ACTIVE CARBONIC ACID ESTER OF POLYETHYLENE GLYCOL
Activated polyethylene glycol with high purity can be obtained by a method including:
a step (a) of reacting polyethylene glycol having a hydroxyl group with one or more active carbonic acid reagents selected from the group consisting of disuccinimidyl carbonate and p-nitrophenylchloroformate in presence of a base in an aprotic solvent which is immiscible with water, to obtain a composition containing an active carbonic acid ester of polyethylene glycol and the active carbonic acid reagent being unreacted,
a step (b) of partially removing the active carbonic acid reagent by filtering the composition obtained in the step (a), and then obtaining a composition by adding an alcohol containing an acidic functional group to react with the unreacted active carbonic acid reagent, and
a step (c) of removing a reaction product of the alcohol containing an acidic functional group and the active carbonic acid reagent, the alcohol containing an acidic functional group, and a decomposition product of the active carbonic acid reagent by washing the composition obtained in the step (b) with water.
A vibration structure (1) is provided with a vibration mass (10), a support part (20), and an elastic part (30). The vibration mass (10) is a plate-shaped portion. The support part (20) is a portion having a space (21) capable of accommodating the vibration mass (10). The elastic part (30) is an elastically deformable portion that connects the vibration mass (10) to the support part (20). The elastic part (30) extends along an outer peripheral edge (13) of the vibration mass (10), and supports the vibration mass (10) such that the vibration mass can vibrate in a direction in which the front surface (11) and the back surface (12) of the vibration mass (10) face the support part (20). The vibration mass (10) has a plurality of corners (14) on the outer peripheral edge (13). The width (W) of a plurality of corners (31) of the elastic part (30) respectively located at the plurality of corners (14) of the vibration mass (10) is wider than the width (w) of sides (32, 33) of the elastic part (30). The widths (W, w) are each distances in directions in which the front surface (11) and the back surface (12) extend.
H04R 1/28 - Transducer mountings or enclosures designed for specific frequency responseTransducer enclosures modified by provision of mechanical or acoustic impedances, e.g. resonator, damping means
G10K 13/00 - Cones, diaphragms, or the like, for emitting or receiving sound in general
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (Japan)
Inventor
Tange, Kota
Yoshioka, Hiroki
Nakai, Yuta
Akita, Hidetaka
Sakurai, Yu
Tanaka, Hiroki
Yoshikawa, Keito
Abstract
The present invention provides a lipid nanoparticle used for delivering a nucleic acid to a lymphatic endothelial cell, including an ionic lipid represented by the formula (1), cholesterol, and a dimyristoylglycerol PEG with a number average molecular weight of PEG chain of 1,000 to 3,000, wherein an amount of the dimyristoylglycerol PEG is not less than 3 mol % with respect to the total of the ionic lipid represented by the formula (1) and the cholesterol (the symbols in the formula (1) are as defined in the specification).
The present invention provides a lipid nanoparticle used for delivering a nucleic acid to a lymphatic endothelial cell, including an ionic lipid represented by the formula (1), cholesterol, and a dimyristoylglycerol PEG with a number average molecular weight of PEG chain of 1,000 to 3,000, wherein an amount of the dimyristoylglycerol PEG is not less than 3 mol % with respect to the total of the ionic lipid represented by the formula (1) and the cholesterol (the symbols in the formula (1) are as defined in the specification).
A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
6.
PRESSURE-REGULATING VALVE FOR POWER STORAGE MODULE
A pressure-regulating valve for a power storage module includes a valve body portion that opens in response to pressure in a power storage module to release the pressure in the power storage module, and an electrolyte reservoir portion provided between the valve body portion and the power storage module, and capable of storing the electrolyte leaking from an inside of the power storage module to a valve body portion side.
The present invention provides a nucleic acid amplification-promoting agent consisting of a polymer containing a constitutional unit derived from a monomer having a phosphorylcholine group.
C12Q 1/6848 - Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
A sealing device is arranged between two relatively displaceable members containing an object to be sealed, for example, a drive shaft of an electric vehicle, and a housing for the drive shaft. A sealing body made of conductive rubber provided in the sealing device is fixed in a state of contact with the housing by an outer peripheral seal, and brings a sealing surface provided on a conductive lip into surface contact with the drive shaft to seal the object. A grease groove is provided on the sealing surface to retain grease having conductivity. The grease is filled between the drive shaft and the sealing surface, and forms a conducting circuit along with the sealing body which makes the drive shaft acting as an antenna for electromagnetic noise and the housing conductive.
F16J 15/3232 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip having two or more lips
F16J 15/16 - Sealings between relatively-moving surfaces
F16J 15/3212 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip provided with tension elements, e.g. elastic rings with metal springs
F16J 15/3284 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings characterised by their structureSelection of materials
An annular gasket made of elastomer contacts with an inner peripheral surface of a hole in an outer member and an outer peripheral surface of an inner member to shut off an inner space of the outer member from an atmospheric space. The gasket includes a first wider portion, a second wider portion, a third wider portion, a first narrower portion, and a second narrower portion. The maximum distance between a first outer peripheral groove and the inner peripheral surface of the hole, the maximum distance between a second outer peripheral groove and the inner peripheral surface of the hole, the maximum distance between a first inner peripheral groove and the outer peripheral surface of the inner member, and the maximum distance between a second inner peripheral groove and the outer peripheral surface of the inner member are each at least 0.05 mm in a compressed state of the gasket.
KOCHI PREFECTURAL PUBLIC UNIVERSITY CORPORATION (Japan)
Inventor
Fujimura, Toshinobu
Nakasato, Katsumi
Iizuka, Muneaki
Sato, Kyohei
Kawaharamura, Toshiyuki
Fukue, Miyabi
Liu, Li
Abstract
Provided is a heat dissipation substrate in which a metal member is provided adjacent to one surface of an insulating layer. The metal member has a material made from copper, a copper alloy, aluminum, or an aluminum alloy and has a sheet shape having a thickness of 0.2-20 mm inclusive. The insulating layer is formed from a first insulating layer and a second insulating layer, and the first insulating layer and the second insulating layer are metal oxide layers including mutually different aluminum oxides. The first insulating layer is a metal oxide layer having a thickness of 0.01-0.2 μm inclusive and a porosity of 10% or less. The second insulating layer is a metal oxide layer having a thickness of 0.3-30 μm inclusive and a porosity of 10% or less.
A crude polyethylene glycol derivative containing a polyethylene glycol derivative having at least one selected from the group consisting of a functional group capable of reacting with a bio-related substance, a functional group serving as a precursor of the functional group, and a protective group for the functional group at a terminal thereof, and impurities are mixed with a mixed organic solvent made from an organic solvent A and an organic solvent B to form a slurry, and the slurry is subjected to repulping washing, and then the polyethylene glycol derivative is recovered from the mixed organic solvent, and the polyethylene glycol derivative is dissolved in a good solvent and then the polyethylene glycol derivative is recovered, and the relation: 0.5≤Y×T≤30 is satisfied as defined herein.
This shock-absorbing stopper is disposed between a flange part having a first annular surface protruding from the outer circumferential surface of a shaft movable in the axial direction and a protruding part having a second annular surface that protrudes toward the shaft from the inner circumferential surface of a tubular housing accommodating the shaft, the second annular surface being apart from the first annular surface. The shock-absorbing stopper comprises: a metal ring in contact with the first annular surface; an annular shock-absorbing body provided between the metal ring and the second annular surface and joined to the metal ring; and an annular member provided between the shock-absorbing body and the second annular surface and joined to the shock-absorbing body, wherein the shock-absorbing body contains a rubber-like elastic material, the metal ring is an annular flat plate, the annular member is apart from the metal ring and provided on the radially inner side of the shock-absorbing body, and the annular member is of higher rigidity than the shock-absorbing body.
A dust cover includes a cover, a cylinder including a first end in a first direction along a central axis of the cylinder and a second end opposite to the first end, an annular first portion connected to the first end, and an annular second portion extending from an outer circumferential surface of the cylinder radially outward. The first portion includes an outer circumferential surface including a first surface inclined radially outward relative to the central axis. The second portion includes a surface facing in the first direction and including a second surface disposed in the first direction from a reference plane perpendicular to the central axis and including the second end, the second surface being at an angle greater than 0 degrees relative to the reference plane. The cover includes an annular seal surrounding the cylinder and being in contact with the first surface and the second surface.
The problem addressed by the present application is to provide a rubber composition having excellent vibration-proofing and sound-deadening properties. The rubber composition disclosed by the present application is a crosslinked rubber composition containing ethylene propylene diene rubber (EPDM), 110–190 parts by mass of carbon black per 100 parts by mass of the ethylene propylene diene rubber, 10–35 parts by mass of an aromatic modified terpene resin per 100 parts by mass of the ethylene propylene diene rubber, a crosslinking agent, and oil. The nitrogen adsorption specific surface area of the carbon black is 70–120 m2/g, the iodine adsorption capacity is 70–125 mg/g, and the DBP oil absorption capacity is 50–100 cm3/100 g.
C08L 23/16 - Ethene-propene or ethene-propene-diene copolymers
C08L 45/02 - Compositions of homopolymers or copolymers of compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic or in a heterocyclic ring systemCompositions of derivatives of such polymers of coumarone-indene polymers
C08L 91/00 - Compositions of oils, fats or waxesCompositions of derivatives thereof
The sunscreen composition contains 2-51 mass% of a component (A), 9-80 mass% of a component (B), 0.1-14 mass% of a component (C), 0.1-10 mass% of a component (D), 5-40 mass% of a component (E), and 6-57 mass% of a component (F). The mass ratio ((A)/(B)) of the component (A) and the component (B) is 5/95-60/40. Component (A): isoparaffin having an average carbon number of 50-250. Component (B): isoparaffin having an average carbon number of 20-24. Component (C): an emulsifier such as a sorbitan fatty acid ester having an HLB of 2-10. Component (D): a polyhydric alcohol that has 2-6 carbon atoms and is dihydric or trihydric. Component (E): an ultraviolet scattering agent. Component (F): water.
An ultrasonic probe includes at least one piezoelectric element configured to transmit and receive ultrasonic waves. The at least one piezoelectric element includes a piezoelectric material formed by a sol-gel process, and at least one electrode being in contact with the piezoelectric material and containing a conductive elastomer.
H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals
B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
H10N 30/06 - Forming electrodes or interconnections, e.g. leads or terminals
H10N 30/078 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by liquid phase deposition by sol-gel deposition
A torsional damper is provided having a hub in which a boss adapted to be fixed to a rotating shaft, such as a crankshaft of an engine, and an annular rim are integrally provided via a plurality of stays, and an annular vibration ring connected to an outer circumferential surface of the rim via an elastic body. The stays have a circumferential width dimension that does not exceed one-quarter of the wavelength of the axial resonant frequency of the hub, and are thickened within a range in which the axial thickness dimension does not exceed one-half of the wavelength of the axial resonant frequency of the hub. Thickening of the stays is implemented by, for example, setting the axial thickness dimension thereof to a length equal to or more than one-quarter of the wavelength of the axial resonant frequency of the hub. The stays have an axially inclined shape.
F02B 67/06 - Engines characterised by the arrangement of auxiliary apparatus not being otherwise provided for, e.g. the apparatus having different functionsDriving auxiliary apparatus from engines, not otherwise provided for of mechanically-driven auxiliary apparatus driven by means of chains, belts, or like endless members
18.
FLOW PATH DEVICE AND METHOD FOR MANUFACTURING SAME
A flow path device (1) is provided with: a base (4) having a first surface (4a) and a second surface (4b) that face away from each other; and a pair of first electrode (10) and second electrode (11). The base (4) has a flow path (7) that extends along the first surface (4a) and the second surface (4b), and the pair of first electrode (10) and second electrode (11) form an electric field that intersects the flow path (7) along a direction in which the first surface (4a) and the second surface (4b) face away.
Provided is an additive for CMP, which contains a polycarboxylic acid-based copolymer that contains, as constituent monomers, 5-95 mol% of (a) a compound represented by formula (1): R1O(AO)nR2(wherein R1represents a hydrocarbon group having 1-18 carbon atoms; R2 represents an unsaturated hydrocarbon group having 2-5 carbon atoms; AO represents one or more types of oxyalkylene groups each having 2-4 carbon atoms; and n represents the average number of moles of oxyalkylene groups added and is a numerical value of 1-100), 0-95 mol% of (b) a maleic acid-based compound, and 0-60 mol% of (c) a compound copolymerizable with the compound (a) and the compound (b) (wherein the total amount of the compound (b) and the compound (c) is 5-95 mol%) and that has a weight average molecular weight of 14,000 or less. As a result, it becomes possible to provide a technique that can prevent the aggregation of abrasive grains and can improve a polishing speed without using grains of a surface-modified metal oxide or the like as the abrasive grains.
H01L 21/304 - Mechanical treatment, e.g. grinding, polishing, cutting
B24B 37/00 - Lapping machines or devicesAccessories
C08F 16/12 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical by an ether radical
C09G 1/02 - Polishing compositions containing abrasives or grinding agents
A rubber product capable of easily and accurately detecting the presence or absence of leakage and a position of the leakage is provided. A rubber product includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction. The rubber product is a sealing member (sealing product 10) for sealing a gap between two members, wherein the sealing member includes a gas chromic material that changes a color thereof reversibly or changes an electric resistance value thereof, due to oxidation-reduction reaction, and has a ring shape.
G01M 3/22 - Investigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipes, cables, or tubesInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for pipe joints or sealsInvestigating fluid tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using special tracer materials, e.g. dye, fluorescent material, radioactive material for valves
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
22.
ZINC CARBOXYLATE SALT FOR PRODUCTION OF SEMICONDUCTOR NANOPARTICLE
A zinc carboxylate salt used in production of a semiconductor nanoparticle, in which a ratio of carboxylic acids having 8 to 10 carbon atoms in whole of carboxylic acids that form the zinc carboxylate salt is 80.0% by mass or more, and an average branching degree of the whole of the carboxylic acids that form the zinc carboxylate salt is in the range of 1.1 to 2.9. The present invention can provide a zinc salt used for easily producing a semiconductor nanoparticle having a core/shell type structure that has excellent optical properties in the case where two or more types of shell precursors are used to produce the semiconductor nanoparticle having a core/shell type structure.
C07C 53/128 - Acids containing more than four carbon atoms the carboxyl group being bound to a carbon atom bound to at least two other carbon atoms, e.g. neo-acids
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
B82Y 40/00 - Manufacture or treatment of nanostructures
C07C 53/126 - Acids containing more than four carbon atoms
An antifogging agent composition which contains a copolymer (A), colloidal silica (B) and a solvent (C), wherein: (A) is a (meth)acrylate copolymer obtained from a monomer mixture which contains monomers (a-1) to (a-3); (C) contains water (C-1), a C1-4 monovalent alcohol-based solvent (C-2), a solvent (C-3) which has one or more functional groups per molecule selected from a ketone group, an ester group, two or more ether groups, a thioketone group and an amide group, and has a boiling point of 100-200° C., inclusive, and a glycol ether-based solvent (C-4) represented by general formula (5) (R10—O—R11—OH); and the combined total of (C-1) to (C-4) relative to 100 parts by mass of the combined total of (A) and (B), and the mass ratios of (C-3) and (C-4) relative thereto, are specific amounts. Also disclosed is an antifogging article including an antifogging coating formed from the antifogging agent composition on a base material.
[Problem] The purpose of the present invention is to provide a polyether-modified organopolysiloxane which has good water solubility without impairing the characteristics of siloxane, while having a polyether chain. [Solution] The present invention provides a polyether-modified organopolysiloxane which is represented by formula (1) and has a block copolymer structure comprising a polyblock structure of oxyethylene and a polyblock structure of oxypropylene. (In the formula, each R independently represents a group selected from among an alkyl group having 1 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, and an aralkyl group having 7 to 10 carbon atoms; x represents an integer of 1 to 100; and each R1independently represents a group represented by formula (2).) (In the formula, R2 represents an alkyl group having 1 to 12 carbon atoms or an acetyl group; n represents an integer of 2 to 10; a represents an integer of 3 to 60; b represents an integer of 3 to 60; b/(a + b) is within the range of 0.3 to 0.8; and oxypropylene in parentheses with the subscript a and oxyethylene in parentheses with the subscript b respectively have polyblock structures in the sequence shown in formula (2).)
A pressure-regulating valve for a power storage module is a pressure-regulating valve for a power storage module in which a case accommodating a valve body in a valve chamber is attached to a power storage device (10), and the case has a sealing surface that is provided with a sealing member and is to contact the power storage device, and an attaching portion attachable to the power storage device by moving along a predetermined slide direction along the sealing surface.
A cushioning stopper includes a ring shaped elastic body that is mountable in a mounting space, and an elastic body restraining member covering part of a periphery of the elastic body and preventing expansion of the elastic body. The elastic body has a first body between two axially displaceable members, and compressed in an axial direction by the two members to expand radially outward when the distance between the two members is reduced, and a second body projecting outward from a peripheral surface of the first body on one end in the axial direction, the elastic body restraining member has an L-shaped cross section covering an end face on the one end side of the elastic body and a peripheral surface of the second body, and the second body has a recess on an end face opposite to the one end side in the axial direction, which is recessed inwardly.
An acetal-type releasable polyoxyethylene derivative containing an amino group, the derivative being characterised by being represented by a specific formula; a method for producing the same; and an acetal-type releasable polyoxyethylene conjugate containing an amino group.
A gasket (1) includes a body portion (10) in an annular shape having a basal surface (11) to contact a bottom surface (113) of a groove(110) and a top surface (12) to contact a second member (200) and extending over an entire circumferential direction of the gasket (1), a first protrusion pair (20) protruding from the body portion (10) respectively toward both side surfaces (111, 112) of the groove (110) and extending over the entire circumferential direction; and a second protrusion pair (30) protruding from the first protrusion pair (20) respectively toward both the side surfaces (111, 112). Respective second protrusions (31, 32) of the second protrusion pair (30) are disposed at a same position in the circumferential direction, and tip ends (31f, 32f) of the respective second protrusions (31, 32) are formed in a planar shape to be along the side surfaces of the groove (110). A first gasket width (W1) of the gasket (1) is smaller than a groove width (W0), and a second gasket width (W2) is larger than the groove width (W0).
A ketal-type releasable polyoxyethylene derivative is expressed by the Formula (1), (2), (3) or (4) as defined herein, and is to be cleaved under a physiological condition, and in the Formulae (1), (2), (3) and (4), B1 represents a hydrogen atom or —C(R1)(R2)OC(O)E1, E1 represents a leaving group, P1 represents a residue obtained by removing a terminal hydroxyl group from a polyoxyethylene derivative having the terminal hydroxyl group, w represents an integer of 1 to 8, R1, R2, R3, R4, R5 and R12 each independently represent a hydrocarbon group having 1 to 10 carbon atoms or a hydrogen atom, R6 represents an optionally substituted hydrocarbon group having 1 to 24 carbon atoms, R7, R8, R9, R10 and R11 each independently represent an electron-withdrawing substituent, an electron-donating substituent, or a hydrogen atom, and m represents 0 or 1.
A flow path member that forms a flow path through which a refrigerant flows by being bonded to a plate-shaped member, the flow path member comprising: a plate part that has a first surface and a second surface facing in the opposite direction to the first surface and that is configured from an elastic material; a first connection part that protrudes from the first surface; and a second connection part that protrudes from the first surface. An introduction port for introducing a refrigerant into the flow path is provided on the outermost end surface of the first connection part, a discharge port for discharging the refrigerant from the flow path is provided on the outermost end surface of the second connection part, and a first opening that communicates with the introduction port and a second opening that communicates with the discharge port are provided in the second surface.
The present invention provides a cryoprotectant for cells that contains an amphoteric polymer having a specific cationic group and a specific anionic group, a hydrophobic amino acid, and a water-soluble cellulose.
The present invention relates to a rubber composition containing a fluorosilicone rubber and silver particles, and a bioelectrode containing the rubber composition.
This hair cosmetic contains (A) 0.1-12 mass% of isoparaffin in which the average number of carbon atoms is 50-250, (B) 0.2-19 mass% of isoparaffin in which the average number of carbon atoms is 20-24, (C) 0.5-5 mass% of at least one compound selected from the group consisting of a quaternary ammonium salt represented by formula (1) and an aliphatic amidoamine represented by formula (2) and salts thereof, (D) 1-10 mass% of an alcohol having 14-24 carbon atoms, and water, the mass ratio ((A)/(B)) between (A) and (B) being 1/20-3/2.
The present invention provides a method for producing a highly-pure branched PEG compound, the method comprising: a step (1a) for mixing, in the presence of a solvent, a porous metal complex with a mixture containing a branched PEG compound and, as an impurity, a linear PEG compound to adsorb the linear PEG compound on the porous metal complex; a step (2a) for removing the porous metal complex having adsorbed the linear PEG compound from the mixture containing the branched PEG compound and the porous metal complex having adsorbed the linear PEG compound to obtain a solution containing the branched PEG compound; and a step (3) for recovering the branched PEG compound from the solution containing the branched PEG compound.
C08G 65/30 - Post-polymerisation treatment, e.g. recovery, purification, drying
B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
The present invention provides a stabilizer for a nucleic acid solution, which is a polymer containing a structural unit derived from a monomer represented by formula (1), wherein the definition of symbols in the formula is as described in the description.
A sealing device (1) is for sealing an annular gap. The sealing device (1) is provided with one seal ring (2). The one seal ring (2) exhibits desired sealing performance with respect to a fluid even in a low-temperature environment.
A method for producing a polyethylene glycol derivative having a carboxyl group at a terminal has a step 1, a step 2, a step 3, and a step 4. Step 1: A polyethylene glycol compound is subjected to an oxidation reaction using an N-oxyl compound to obtain a polyethylene glycol derivative having a carboxyl group at a terminal. A reducing agent is then added to quench the oxidation reaction to obtain a mixed aqueous solution containing a reduced form of the N-oxyl compound and a polyethylene glycol derivative having a carboxyl group at a terminal. Step 2: The mixed aqueous solution which has been adjusted to a pH of 3.0 or less is mixed with an organic solvent containing one or more selected from the group consisting of aromatic hydrocarbons, carboxylic acid alkyl esters, and halogenated hydrocarbons, at 0°C or higher, and the mixture is separated into an organic layer and a water layer. Step 3: The organic layer obtained in step 2 and an aqueous solution adjusted to a pH of 3.0 or less are mixed at 0°C or higher, and the mixture is separated into an organic layer and a water layer. Step 4: A polyethylene glycol derivative having a carboxyl group is recovered by concentrating the organic layer obtained in step 3.
A pressure regulating valve is attached to each of a plurality of power storage modules. The pressure regulating valve allows internal spaces of the power storage modules to be open, respectively, and has a short-circuit preventing structure for preventing an electrolytic solution coming outside of the power storage modules from causing a short circuit with another power storage module or a short circuit between other power storage modules.
H01M 50/325 - Re-sealable arrangements comprising deformable valve members, e.g. elastic or flexible valve members
H01M 50/59 - Means for preventing undesired use or discharge for preventing incorrect connections inside or outside the batteries characterised by the protection means
An ophthalmic composition according to the present invention comprises: (A) 0.01-0.5 w/w% of a copolymer which has structural units represented by formula (1a) to formula (1c), in which the molar ratio a:b:c between the structural units is 100 : 10-400 : 2-50, and which has a weight-average molecular weight of 5,000-2,000,000; (B) 0.001-0.02 w/w% of benzalkonium chloride; and/or (C) 0.001-0.05 w/w% of chlorhexidine gluconate. The present invention makes it possible to provide an ophthalmic composition that exhibits sufficient preservative efficacy and protects corneal cells.
The present invention provides a method for producing ligand-modified lipid nanoparticles encapsulating a nucleic acid, said method comprising the following steps a) to c), etc. Step a) Mixing an alcohol solution comprising an ionic lipid, a sterol, and a PEG lipid with an acidic buffer solution having a pH of 1-6.5, thereby obtaining a suspension of lipid nanoparticles that do not include a nucleic acid. Step b) Mixing the lipid nanoparticles that do not include a nucleic acid with a nucleic acid solution, thereby obtaining a suspension of lipid nanoparticles that encapsulate a nucleic acid. Step c) Mixing the suspension of lipid nanoparticles that encapsulate a nucleic acid with a ligand-bonded lipid, thereby obtaining a suspension of ligand-modified lipid nanoparticles that encapsulate a nucleic acid.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A center bearing support suitable for suppressing the decrease in vibration absorbing capability in a high-frequency region is realized.
A center bearing support suitable for suppressing the decrease in vibration absorbing capability in a high-frequency region is realized.
The center bearing support includes an outer ring 3 that has a cylindrical shape and is attached to a member on a vehicle body side in such a manner that an outer peripheral surface 3b thereof is in contact with the member, an inner ring 2 that has a cylindrical shape and is attached to the center bearing in such a manner that an inner peripheral surface 2b thereof is in contact with an outer periphery of the center bearing, and an elastic body 1 that is connected to an inner peripheral surface 3a of the outer ring 3 and an outer peripheral surface 2a of the inner ring 2 and expands in a bellows-like bent shape which is convex toward one direction along the propeller shaft between the inner peripheral surface 3a of the outer ring 3 and the outer peripheral surface 2a of the inner ring 2, wherein the elastic body 1 includes a base part 15 that has a shape of a bent plate and expands in the bellows-like bent shape while maintaining a constant thickness thereof, between the inner peripheral surface 3a of the outer ring 3 and the outer peripheral surface 2a of the inner ring 2, and a convex part 14 that is layered on a convex surface 11a of a bent portion of the base part 15 and protrudes toward one direction, and the base part 15 and the convex part 14 are integrally formed of an elastic material.
There is provided a battery buffering member that has heat insulating performance by including heat insulating members, and the heat insulating performance is hardly deteriorated even when the buffering member is compressed under an external force in a thickness direction thereof. The battery buffering member comprises an elastic member having protruding portions, and heat insulating members that are plate-like structures having through-holes formed thereon, wherein the heat insulating members are disposed on one surface side and the other surface side of the elastic member, respectively, and the protruding portions of the elastic member protrude from the through-holes of the heat insulating members.
H01M 50/293 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by spacing elements or positioning means within frames, racks or packs characterised by the material
H01M 10/658 - Means for temperature control structurally associated with the cells by thermal insulation or shielding
H01M 50/242 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by physical properties of casings or racks, e.g. dimensions adapted for protecting batteries against vibrations, collision impact or swelling
A method for producing an activated polyethylene glycol compound having a carbamate bond between a polyethylene glycol moiety and a functional group capable of reacting with a bio-related substance or a precursor of the functional group, includes: reacting a polyethylene glycol raw material having a nitrophenyl group at a terminal thereof with an amine compound having the functional group capable of reacting with the bio-related substance or the precursor of the functional group in a solution containing an aprotic solvent to obtain a reaction mixture containing the activated polyethylene glycol compound and 4-nitrophenol; adding a basic aqueous solution having a pH of 10 or more and 14 or less to the reaction mixture to obtain a two-phase mixture; and separating an organic layer of the two-phase mixture from an aqueous layer of the two-phase mixture and recovering the activated polyethylene glycol compound from the organic layer.
A cushioning sheet having an elastic body and including a flat plate, and a plurality of protruding portions that protrudes from the flat plate, an interior of each protruding portion being a cavity that opens in an opposite direction to a protrusion direction, wherein at least one of an inner surface and an outer surface of the protruding portion is provided with a groove that serves as a deformation starting point when the protruding portion is compressed and deformed.
F16F 1/44 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by the mode of stressing loaded mainly in compression
F16F 1/373 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by having a particular shape
F16F 1/376 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by having a particular shape having projections, studs, serrations or the like on at least one surface
H01M 50/242 - MountingsSecondary casings or framesRacks, modules or packsSuspension devicesShock absorbersTransport or carrying devicesHolders characterised by physical properties of casings or racks, e.g. dimensions adapted for protecting batteries against vibrations, collision impact or swelling
A method for producing a laminate includes: a first applying step of applying a first adhesive to a first surface of a first member, the first member being made of silicone rubber, the first adhesive including a silane coupling agent having epoxy groups; a second applying step of applying a second adhesive to a second surface of a second member, the second member being made of polystyrene, the second adhesive including a silane coupling agent having amino groups; and a bonding step of the first surface of the first member and the second surface of the second member to each other with the first adhesive and the second adhesive.
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 25/08 - Layered products essentially comprising natural or synthetic rubber comprising rubber as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
B32B 37/10 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the pressing technique, e.g. using direct action of vacuum or fluid pressure
B32B 37/12 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
46.
DISPERSANT FOR CONDUCTIVE PASTE AND CONDUCTIVE PASTE
The present invention provides a dispersant for a conductive paste containing a component (A) represented by formula (1) and a component (B) represented by formula (2), wherein the content of the component (A) is 93-99.9 mass% and the content of the component (B) is 0.1-7 mass% with respect to the entire dispersant. Formula (1): R1CO-NH-(R2)-OH (in formula (1), R1CO represents an aliphatic acyl group that has 6-22 carbon atoms and may have a hydroxy group, and R2represents an alkylene group having at least 2 and no more than 3 carbon atoms). Formula (2): R3CO-OH (in formula (2), R3CO represents an aliphatic acyl group having 6-22 carbon atoms).
A method of manufacturing a hub seal is provided. In the method, a lip reaction force F/hub diameter D and a lip surface roughness R are selected from within a designed region, which is a region of the lip reaction force F/hub diameter D and the lip surface roughness R, set in advance on the basis of a value (lip reaction force F/hub diameter D) given by dividing a reaction force F, which is a value of a reaction force of the side lip in an in-use state, by a hub diameter D, which is a value of a diameter of a hub, and the lip surface roughness R, which is a value of a surface roughness of a seal surface of the side lip. The hub seal is designed such that the lip reaction force F/hub diameter D and the lip surface roughness R become the selected lip reaction force F/hub diameter D and lip surface roughness R. The hub seal is manufactured based on the designed hub seal.
A method for manufacturing a seal body includes a belt-like body forming step including a crosslinking agent adding step in which a crosslinking agent is added to a compound containing a halogen group-containing monomer as a constituent unit and mixed, a kneading step for kneading the obtained mixture, a pressurizing step for pressurizing the kneaded material, and a cutting step for cutting the pressurized body into a belt-like body, and a press-fixing step including a press-fixing/heating step of press-fixing one end and the other end of the belt-like body to form an endless seal body.
C09J 133/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
B29D 99/00 - Subject matter not provided for in other groups of this subclass
The present invention provides a novel sealing device capable of suppressing friction even in boundary lubrication or mixed lubrication. A sealing device (1) comprises a seal member (6). The seal member (6) contains a rubber composition. The rubber composition contains a compound having a functional group at a terminal and having an aliphatic hydrocarbon group having 4 or more carbon atoms.
This oil/seal lubrication system comprises a seal member, and a slide member that moves relative to the seal member and comes into contact with the seal member via lubricating oil. The seal member contains an inorganic filler, and at least one of the seal member and the lubricating oil contains an ashless friction modifier.
124n2122 represents a C2-5 unsaturated hydrocarbon group, and n is the average number of moles of an oxyalkylene group added and represents 1-10. The present invention makes it possible to provide a dispersant which can exhibit a good dispersion effect and reduce the viscosity of a slurry composition even when the ratio of an inorganic powder is varied or the dispersant is added in a small amount.
Provided are a gear and a gear damper that enable noise reduction and offer excellent versatility. A gear includes: a metal gear body; and a damper unit that is provided to cover at least a meshing surface of each of teeth in the gear body and has a surface made of an elastic body. As a result, the gear enables noise reduction and offers excellent versatility.
The present invention provides a modifier for solid electrolytes that comprises: an ionic compound which comprises a pyrrolidinium cation and an anion including fluorine or a cyano group; a borate ester which has a polymerizable functional group; and a lithium salt.
H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
H01G 11/56 - Solid electrolytes, e.g. gelsAdditives therein
A carbonate (meth)acrylate composition contains 99 to 99.99 mass % of carbon (meth)acrylate and 0.01 to 1 mass % of an ascorbic acid derivative represented by formula (1),
A carbonate (meth)acrylate composition contains 99 to 99.99 mass % of carbon (meth)acrylate and 0.01 to 1 mass % of an ascorbic acid derivative represented by formula (1),
A carbonate (meth)acrylate composition contains 99 to 99.99 mass % of carbon (meth)acrylate and 0.01 to 1 mass % of an ascorbic acid derivative represented by formula (1),
in the formula (1), R1, R2 and R3 independently represent a hydrogen atom, an alkyl group having a carbon number of 1 to 20 or an acyl group having a carbon number of 1 to 20, respectively.
A plate shaped gasket mounting member having an endless gasket endlessly formed integrally therewith has through holes in a gasket mounting area. The gasket includes an endless first base disposed on an opposing surface, that extends along the mounting area, and that has a width which is wider than a hole size of each through hole, an endless second base disposed on a non-opposing surface, that extends along the mounting area, and that has a width wider than the hole size of each through hole and narrower than the first base, a third base disposed within each through hole and connects the first base and the second base, and a lip that protrudes, so that a distal end thereof is not included in an extension region of each through hole, from the first base in a direction away from each of the opposing surface and the extension region.
Provided is a thermoplastic resin composition containing a thermoplastic resin (L), a paraffin-based hydrocarbon solvent (M), and a styrene-based elastomer (N), wherein: the thermoplastic resin (L) is at least one selected from the group consisting of a polycarbonate resin, and a resin having a rubbery polymer, a vinyl cyanide-based monomer, and an aromatic vinyl-based monomer as a constituent unit; the paraffin-based hydrocarbon solvent (M) has an aniline point of at least 110 °C; and the styrene-based elastomer (N) is a block copolymer including a polymer block having polystyrene and a polymer block having a conjugated diene compound. The thermoplastic resin composition has excellent noise-reduction characteristics while maintaining or improving the low-temperature impact resistance of a thermoplastic resin.
C08L 51/04 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to rubbers
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
C08L 69/00 - Compositions of polycarbonatesCompositions of derivatives of polycarbonates
C08L 91/00 - Compositions of oils, fats or waxesCompositions of derivatives thereof
NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITY (Japan)
Inventor
Hanada, Yuki
Sakai, Yohei
Sato, Hiroyuki
Tadokoro, Chiharu
Abstract
This sealing device seals a gap between two members that rotate relatively around an axis. The device is provided with: a metal ring that is fixed to one of the two members and forms an annular shape around the axis; and an elastic body that is supported by the metal ring and forms an annular shape around the axis. The elastic body has an annular base part that is joined to the metal ring, and a cylindrical side lip that protrudes from the base part and contacts the other member of the two members. The outer peripheral surface of the side lip is provided with a plurality of ribs that are spaced apart from each other in the circumferential direction centered on the axis.
F16J 15/3204 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip
F16J 15/3252 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings provided with casings or supports with rigid casings or supports
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (Japan)
Inventor
Tange, Kota
Yoshioka, Hiroki
Nakai, Yuta
Akita, Hidetaka
Sakurai, Yu
Tanaka, Hiroki
Iwasaki, Koki
Abstract
The present invention provides a lipid nanoparticle including an ionic lipid represented by the following formula (1) wherein the symbols are as defined in the specification and an activated PEG lipid-bonded ligand having cell directivity.
The present invention provides a lipid nanoparticle including an ionic lipid represented by the following formula (1) wherein the symbols are as defined in the specification and an activated PEG lipid-bonded ligand having cell directivity.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
Disclosed is a battery which includes: a plurality of cells; a plurality of buffer sheets 100 which are each disposed between adjacent cells; and a coolant passage for flowing a coolant so that the coolant passes through a region where the buffer sheet 100 is disposed between adjacent cells. This battery is characterized in that the buffer sheets 100 each include: a flat plate part 110; a plurality of projection parts 120 that protrude to both surface sides of the flat plate part 110; and a plurality of through holes 130 that are provided so as to penetrate both surfaces of the flat plate part 110.
A hub seal (1) is provided with a seal body (3) and a slinger (4). The seal body (3) is provided with a reinforcing ring (10) and an elastic body part (20). The slinger (4) is provided with a flange part (31) and a cylindrical part (32). An outer cylindrical surface (3a), which is a surface of cylinder form, is formed on the seal body (3). The elastic body part (20) has a side lip (21) farther to the inner periphery than the outer cylindrical surface (3a). The cylindrical part (32) of the slinger (4) is positioned farther to the outer periphery than the side lip (21) and has at the inner end an annular weir part (33) that extends toward the outer periphery. The outer cylindrical surface (3a) faces the cylindrical part (32) from the outer peripheral side. Between the outer cylinder surface (3a) and an end (33a) of the weir part (33), there is formed a first gap (S1) of which the radial width (W1) is less than the radial width (W2) of a second gap (S2) formed between the outer cylinder surface (3a) and a portion of the weir part (33) that faces the outer cylinder surface (3a) and that is not the end (33a).
F16C 19/18 - Bearings with rolling contact, for exclusively rotary movement with bearing balls essentially of the same size in one or more circular rows for both radial and axial load with two or more rows of balls
F16C 33/78 - Sealings of ball or roller bearings with a diaphragm, disc, or ring, with or without resilient members
F16J 15/3232 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip having two or more lips
F16J 15/3256 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings provided with casings or supports with rigid casings or supports comprising two casing or support elements, one attached to each surface, e.g. cartridge or cassette seals
A hub seal (1) is provided with a seal body (3) and a slinger (4). The slinger (4) is provided with a flange part (31) and a tubular part (32). An outer tubular surface (3a) is formed on the seal body (3). A labyrinth lip (40) extends toward the tubular part (32) of the slinger (4) on the outer peripheral side with respect to the side lip (21). The tubular part (32) of the slinger (4) has a weir part (33). The outer tubular surface (3a) forms a first gap (S1) and a second gap (S2) between the outer tubular surface (3a) and the tubular part (32). The weir part (33) forms a third gap (S3) between the weir part (33) and a part of an elastic body part (20). The labyrinth lip (40) forms a fourth gap (S4) between the labyrinth lip (40) and the tubular part (32). A space (S5) between the tubular part (32) and the side lip (21) communicates with the outside of the second gap (S2) via the fourth gap (S4), the third gap (S3), the first gap (S1), and the second gap (S2).
F16C 19/38 - Bearings with rolling contact, for exclusively rotary movement with bearing rollers essentially of the same size in one or more circular rows, e.g. needle bearings for both radial and axial load with two or more rows of rollers
F16J 15/3232 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings with at least one lip having two or more lips
F16J 15/3256 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings provided with casings or supports with rigid casings or supports comprising two casing or support elements, one attached to each surface, e.g. cartridge or cassette seals
A sealing device and a sealing structure with which an improvement is achieved in terms of suppressing the infiltration of foreign matter such as muddy water. An elastic seal includes a main lip, a side lip, and an intermediate lip, and a second annular recess formed along an outer peripheral surface of the side lip is recessed in a central axis direction of an inner ring and toward a sealing target space side by a greater depth than a first annular recess formed between the side lip and the intermediate lip.
This sealing device is configured by joining two members which are like a case and cover, with a metal divided gasket sandwiched therebetween. The divided gasket is divided into a plurality of pieces that each have, at front and back surfaces thereof, a flat seal surface which is covered with an elastic body. The individual pieces are connected with hinges so as to form an annular shape when assembled. The hinges each bridge across seal surfaces of two adjacent pieces and rotate about an axis orthogonal to the lengthwise direction of the two adjacent pieces, thereby connecting the two pieces in a foldable manner. At least one of the two members is provided with a recess that accommodates a hinge protruding from the seal surface. The recess is filled with a liquid gasket that covers a portion where the two adjacent pieces are connected.
The present invention addresses the problem of providing a hydrophilicity-imparting agent capable of imparting hydrophilicity and low-friction properties to a resin. A hydrophilicity-imparting agent for solving the aforementioned problem includes: a cis amide that is an amide of a C16-24 aliphatic amine a and a C16-24 fatty acid b, at least one of the aliphatic amine a and the fatty acid b including a cis-unsaturated structure, and no trans-unsaturated structures being included in the aforementioned structure; and a trans amide that is an amide of a C16-24 aliphatic amine c and a C16-24 fatty acid d, at least one of the aliphatic amine c and the fatty acid d including a trans-unsaturated structure, and no cis-unsaturated structures being included in the aforementioned structure. The mass ratio of the cis amide and the trans amide is 99.9:0.1 to 50:50.
An anti-vibration rubber composition is provided in which the ratio of the storage elastic modulus E′ at −30° C. to the storage elastic modulus E′ at 90° C. after crosslinking (−30° C./90° C.) is 6.4 or less, as measured with reference to JIS K6394: 2007.
A gear structure includes a gear member including: an outer circumferential surface provided with a plurality of gear teeth; and an inner circumferential surface disposed in an inward direction from the outer circumferential surface; an annular mass body disposed in the inward direction from the inner circumferential surface; and an elastic body interposed between the gear member and the mass body.
A sheet-shaped cushioning rubber including a planar base portion and a three-dimensional portion formed to rise from the base portion toward one side in a sheet thickness direction, the planar base portion and the three-dimensional portion being alternately provided in one direction of a sheet plane, wherein the three-dimensional portion includes a hollow portion that opens toward the other side in the sheet thickness direction. The three-dimensional portion is integrally provided with a first rising surface that is continuous from the base portion, a top surface, a second rising surface on a side opposite to the first rising surface, and a pair of rising surfaces on both sides in a sheet width direction, and the hollow portion opens only toward the other side in the sheet thickness direction.
F16F 1/376 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by having a particular shape having projections, studs, serrations or the like on at least one surface
F16F 1/371 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by inserts or auxiliary extension elements, e.g. for rigidification
F16F 1/377 - Springs made of plastics, e.g. rubberSprings made of material having high internal friction characterised by having a particular shape having holes or openings
F16F 3/087 - Units comprising several springs made of plastics or the like material
F16F 15/08 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system using elastic means with rubber springs
F16M 11/22 - Undercarriages with or without wheels with approximately constant height, e.g. with constant length of column or of legs
A fluororubber composition comprising 0.1 to 1 parts by weight of a compound represented by the general formula:
A fluororubber composition comprising 0.1 to 1 parts by weight of a compound represented by the general formula:
A fluororubber composition comprising 0.1 to 1 parts by weight of a compound represented by the general formula:
(wherein any two of R1, R2, and R5 are lower alkyl groups having 1 to 5 carbon atoms, preferably a tert-butyl group or a tert-amyl group, and the remaining one is hydrogen, and X is a methyl group or a hydroxyl group) and having a number average molecular weight Mn of 200 to 300, based on 100 parts by weight of peroxide-crosslinkable fluororubber. The fluororubber composition that can be vulcanized at a high speed and has excellent scorch stability. Moreover, the crosslinked product can obtain stable product quality.
The present invention provides four-branched water-soluble polymers for medical use that are represented by the following formula (1) or the formula (2) (the symbols in the following formulas are as defined in the specification.
The present invention provides four-branched water-soluble polymers for medical use that are represented by the following formula (1) or the formula (2) (the symbols in the following formulas are as defined in the specification.
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
C08G 65/32 - Polymers modified by chemical after-treatment
A gear structure includes a gear member including an outer circumferential surface provided with a plurality of gear teeth, and a band member surrounding the gear member and pressing the plurality of gear teeth inwardly.
The present invention provides an ester synthesized from a component A that is at least one selected from C2-8 divalent alcohols, a component B that is at least one selected from C2-10 divalent carboxylic acids, and a component C that is at least one selected from C4-6 hydroxycarboxylic acids having two or more carboxy groups.
This sealing structure is provided with: a first member in which a mounting hole is formed; a second member that faces the first member; a fastener that is inserted into the mounting hole and fastens the first member and the second member; and a gasket that includes a plurality of constituent parts positioned between the first member and the second member. The plurality of constituent parts include a first constituent part that includes a first end surface, and a second constituent part that includes a second end surface facing the first end surface. The fastener is positioned between the first end surface and the second end surface.
This electrode for living bodies is provided with: a porous base material in which a plurality of pores are formed; and a conductive coating material that coats the surface of the porous base material and the inner surfaces of the plurality of pores.
A sealing device is provided to achieve sealing between an outer-periphery-side member and an inner-periphery-side member that are able to relatively rotate, and includes: an outer seal member to be attached to the outer-periphery-side member; and an inner seal member to be attached to the inner-periphery-side member. The outer seal member includes an annular member that includes an inner tubular portion extending along an axis direction and a seal lip portion that slide-contacts the inner seal member on a side closer to an internal space than the annular member. The inner seal member includes an inner contact portion that includes a plurality of protrusions and slide-contacts the inner tubular portion. A length of a region of the inner contact portion where the plurality of protrusions are formed is longer than a minimum interval between facing portions of the outer seal member and the inner seal member.
This rubber composition contains (A) a polymer, (B) a crosslinking agent, and (C) a coloring agent. The coloring agent (C) does not contain an inorganic black pigment. As a rubber sheet, the rubber composition demonstrates: a minimum transmittance at a wavelength of 800-1600 nm of 50% or greater; a minimum transmittance at a wavelength of 900-1100 nm of 80% or greater; a maximum transmittance at a wavelength of 300-700 nm of 40% or less; and a maximum transmittance at a wavelength of 300-650 nm of 1% or less.
A sealing device includes an annular reinforcing ring fixed to a housing, an annular elastic member that includes a fixing portion fixed to the reinforcing ring, and a lip that protrudes from the fixed portion and is in slidable contact with an outer peripheral surface of a shaft, and at least one annular spring that presses the lip against the outer peripheral surface of the shaft, the lip being between the at least one spring and the outer peripheral surface of the shaft. The elastic member is made of an electrically conductive elastic material. A contact surface, which is a part of the lip and is in contact with the outer peripheral surface of the shaft, is straight when viewed in a cross section defined by a plane that includes a central axis of the elastic member. A width of the at least one annular spring is greater than its thickness.
F16J 15/3284 - Sealings between relatively-moving surfaces with elastic sealings, e.g. O-rings characterised by their structureSelection of materials
F16J 15/324 - Arrangements for lubrication or cooling of the sealing itself
H02K 5/10 - Casings or enclosures characterised by the shape, form or construction thereof with arrangements for protection from ingress, e.g. of water or fingers
A sealing device is configured to seal a clearance between a housing and a shaft of a hydraulic cylinder. The sealing device includes an annular packing that is disposed within the clearance and comprises an elastic material, and a back-up ring that is in contact with the packing. The back-up ring has a contact surface that is in contact with the shaft, and a portion including at least the contact surface of the back-up ring comprises a resin composition that includes a base material and a filler material. The base material comprises a polyamide resin, and the filler material comprises a polyolefin resin that is compatible with the polyamide resin.
A sealing structure having a circular pillar-shaped shaft that has an annular groove, which is continuous in a circumferential direction, on an outer circumferential surface, a housing having a shaft hole into which the shaft is inserted, a seal ring which seals a gap between the shaft and the housing, and a backup ring disposed on the low-pressure side of the seal ring inside the annular groove, wherein: there is a tapered surface α on the low-pressure side of the groove bottom of the annular groove; a taper angle θα is 15° to 50°; the backup ring has a tapered surface β; and a taper angle θβ is larger than the taper angle θα.
17 - Rubber and plastic; packing and insulating materials
Goods & Services
Gaskets; Junctions for pipes, not of metal; Joint packings; O-rings; Washers of rubber or vulcanized fiber; Chemical fiber, not for textile use; Rings of rubber; Rubber cords and laces; Industrial packaging containers of rubber; Rubber stoppers; Rubber lids and caps for industrial packaging containers; Electrical insulating materials; Adhesive tapes, other than stationery and not for medical or household purposes; Plastic semi-worked products; Rubber [raw or semi-worked]; bands, of synthetic resin.
This laminate comprises: a first member, which is made of a silicone rubber; a second member, which is made of a polycarbonate; and a bonding layer which is formed from a silane coupling agent having a glycidyl group and by which the first member is bonded to the second member.
B32B 25/08 - Layered products essentially comprising natural or synthetic rubber comprising rubber as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
C09J 5/02 - Adhesive processes in generalAdhesive processes not provided for elsewhere, e.g. relating to primers involving pretreatment of the surfaces to be joined
A heat conducting structure (1) comprises a soft heat conducting member (10) that is a soft member having thermal conductivity. The soft heat conducting member (10) is a member that is capable of maintaining the shape thereof. The soft heat conducting member (10) is filled between a heat dissipating member (2) and a receiving member (3).
A seal material (100) comprises a seal material body (10) that fulfills a sealing function between members, and a detection unit (20) that changes color when in contact with a gas to be detected.
NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (Japan)
Inventor
Tange, Kota
Yoshioka, Hiroki
Nakai, Yuta
Akita, Hidetaka
Sakurai, Yu
Tanaka, Hiroki
Fujita, Shoya
Abstract
The present invention provides a lipid nanoparticle used for delivering a nucleic acid to a brain tissue, including an ionic lipid represented by the formula (1), phospholipid, cholesterol, and a dimyristoylglycerol PEG with a number average molecular weight of PEG chain of 4,000 to 6,000, wherein an amount of the dimyristoylglycerol PEG is 1 to 6 mol % with respect to the total of the ionic lipid represented by the formula (1), the phospholipid, and the cholesterol (the symbols in the formula (1) are as defined in the specification).
The present invention provides a lipid nanoparticle used for delivering a nucleic acid to a brain tissue, including an ionic lipid represented by the formula (1), phospholipid, cholesterol, and a dimyristoylglycerol PEG with a number average molecular weight of PEG chain of 4,000 to 6,000, wherein an amount of the dimyristoylglycerol PEG is 1 to 6 mol % with respect to the total of the ionic lipid represented by the formula (1), the phospholipid, and the cholesterol (the symbols in the formula (1) are as defined in the specification).
A pipe connection tool (11) for connecting two pipes is mainly configured from a cylindrical elastic body (21) made of rubber, connection parts (22A, 22B) respectively fitted to the two pipes being provided at both ends, and a film part (23) being provided in a center portion. A first reinforcing ring (31) is embedded in one connection part (22A), and a second reinforcing ring (41) is embedded in the other connection part (22B). The first reinforcing ring (31) has a first cylindrical part (32) and a first flange (33), and the second reinforcing ring (41) has a second cylindrical part (42) and a second flange (43). The first flange (33) receives the force of a jig in a direction from the other connection part (22B) toward the one connection part (22A), and the second flange (43) receives, on the outer-peripheral side of the elastic body (21), the force of a jig in a direction from the one connection part (22A) toward the other connection part (22B).
[Problem] To provide a gasket which has high shape conformability to an object to be brought into contact therewith, and has excellent pressure resistance and heat resistance. [Solution] A gasket 1 comprises: a plurality of flow path parts 10, each of which is a cylindrical member and has a pair of openings 11, 12; and a base body 20 which has a front surface 21 and a back surface 22 that constitute a pair of surfaces opposite to each other. The base body 20 has elasticity. The flow path parts 10 are held by the base body 20 so as to form flow paths for a sealing target object such that the openings 11, 12 respectively open in the front surface 21 and the back surface 22 of the base body 20. The hardness of the base body 20 is lower than the hardness of the flow path parts 10.
A hollow fiber membrane module 10 comprises: an outer case 100; an inner case 200; a hollow fiber membrane bundle 300 composed of a plurality of hollow fiber membranes filled in an annular gap between the outer case 100 and the inner case 200; a first sealing part 410; and a second sealing part 420, the hollow fiber membrane module 10 having formed therein a membrane exterior passage, which passes from an opening in the inner case 200, through a first through hole 230, past the exteriors of the plurality of hollow fiber membranes, and to a second through hole 130, and, and a membrane interior passage, which passes through the interiors of the plurality of hollow fiber membranes, said hollow fiber membrane module 10 being characterized in that a cylindrical member 500 having a plurality of third through-holes 510 that form a part of the membrane exterior passage is provided between the hollow fiber membrane bundle 300 and the outer case 100.
A fuel cell composite sheet having high handleability and a method for manufacturing a fuel cell composite sheet. The fuel cell composite sheet includes a frame body, a membrane electrode assembly which is disposed in the frame body and which includes a gas diffusion layer, and a holding member as a sheet. The holding member is harder than the frame body and holds the membrane electrode assembly. It is possible to prevent warpage by holding the membrane electrode assembly by using the holding member. This makes it possible to improve handleability at the time of molding, assembling, and the like.
A gasket includes protrusion portions that respectively protrude to contact side surfaces facing each other of the groove to which the gasket is to be attached, an upper side seal lip portion that is formed to contact one of surfaces facing each other between members, a lower side seal lip portion that is formed to contact another one of the surfaces facing each other between the members, and a joining portion that joins the upper side seal lip portion and the lower side seal lip portion, wherein the joining portion extends along a virtual straight line in a section of the gasket, the upper side seal lip portion has upper side seal lips extending side by side between the protrusion portions in the joining portion, the lower side seal lip portion has lower side seal lips extending side by side between the protrusion portions in the joining portion, each of the upper side seal lips is tapered, and each of the lower side seal lips is tapered.
A pressure-regulating valve for a power storage module includes a case having a recessed part, and a through-hole formed in a bottom portion of the recessed part, a valve body positioned in the recessed part and capable of opening and closing the through-hole by elasticity, and a plug body that closes the recessed part, and the case and the plug body are attachably and detachably fixed.
H01M 50/325 - Re-sealable arrangements comprising deformable valve members, e.g. elastic or flexible valve members
F16K 17/02 - Safety valvesEqualising valves opening on surplus pressure on one sideSafety valvesEqualising valves closing on insufficient pressure on one side
H01M 50/308 - Detachable arrangements, e.g. detachable vent plugs or plug systems
Provided is a sealing structure capable of suppressing, when a gasket is mounted on a mounting groove, a part of the gasket from getting loose from the mounting groove. A gasket 300 is provided with: an annular gasket body part 310 mounted on a mounting groove 210; and a plurality of protrusions 320 provided on an inner peripheral surface of the gasket body part 310 at intervals in a circumferential direction. In a state before the gasket 300 is mounted on the mounting groove 210, and a first member and a second member are fixed, the gasket 300 is characterized in that the protrusion 320 contacts a side wall surface on one side of the mounting groove 210, and the gasket body part 310 has a meandering part 312 not in contact with side wall surfaces on both sides of the mounting groove 210.
The disclosure provides a steering dust seal which seals a gap between a shaft hole of a column hole provided in a dashboard and a steering shaft. The steering dust seal includes an annular mounting portion attached to an inner peripheral surface of the shaft hole, an annular bumper facing the steering shaft in a non-contact state, a bellows connecting the mounting portion and the bumper, and a seal lip extending from the bumper to contact with the steering shaft. A lip included in the seal lip is covered over its entire circumference with a resin-made sliding portion having a friction coefficient preventing abnormal noise from occurring due to a stick-slip phenomenon between the rotating steering shaft and the sliding portion.
Provided is an electrically conductive structure with which it is possible to suppress deterioration of conductive performance in a use state while saving space. The electrically conductive structure (1) comprises a holding member (2) that has annular electric conductivity around an axis x, and an electrically conductive member (3) that is annular around the axis (x). The electrically conductive member (3) has a gap (10) that is provided so as to extend in at least one radial direction, and an electrically conductive body (20) that is electrically conductive and extends around at least one axis x. The electrically conductive member (3) is held by the holding member (2). The electrically conductive body (20) has a pair of ends (20a, 20b) in the direction around the axis x. The gap (10) is continuous with the ends (20a, 20b) of the electrically conductive body (20).
The present invention provides an analysis method including separating a compound of the formula (1):
The present invention provides an analysis method including separating a compound of the formula (1):
The present invention provides an analysis method including separating a compound of the formula (1):
contained in a polyoxyethylene derivative by reversed-phase chromatography, and detecting the compound with an ultraviolet visible spectrometer detector, in which ultraviolet light with a wavelength shorter than 200 nm as the detection wavelength is used, and an acidic substance with a maximum molar absorption coefficient of not more than 20 M−1cm−1 at 190 to 200 nm and a pKa of not more than 4 is used as an additive to the mobile phase for analysis.
The present invention addresses the problem of providing a sealing device capable of achieving long-term electrical conductivity between a rotary shaft and a housing at low cost and in a space-saving manner. The problem is solved by a sealing device that is disposed in and seals a gap between an outer surface of a rotary shaft and an inner surface of a housing having a shaft hole into which the rotary shaft is inserted, the inner surface forming the shaft hole, and that can provide electrical conductivity between the housing and the rotary shaft pressed against the inner surface of the housing forming the shaft hole when the rotary shaft rotates.
A sealing device (1) comprises: a reinforcement ring (10); and an elastic body part (20) that has a seal lip (21) and that is formed from an elastic body attached to the reinforcement ring (10). An atmosphere-side surface (23) of a lip distal end (22) of the seal lip (21) includes: a suppression part (30) for suppressing leakage of a sealed fluid to an atmosphere side (a) during forward rotation of a rotating shaft (50); and a storage part (40) for storing the sealed fluid leaked to the atmosphere side (a) during reverse rotation of the rotating shaft. The suppression part (30) has a plurality of screw projections (31) that serve to return the leaked sealed fluid to a sealed object side (b) by means of a pump function when the rotating shaft rotates forward. The storage part (40) has a dam section (41) that, when the rotating shaft rotates in reverse, serves to dam the sealed fluid leaked to the atmosphere side (a).
An EPDM composition that includes 1 to 12 parts by weight of liquid polybutadiene and 1 to 12 parts by weight of a plant-derived component-containing terpene resin based on 100 parts by weight of a plant-derived component-containing ethylene-propylene-diene terpolymer. The EPDM composition is obtained by adding, to EPDM that has, at least in part, a plant-derived component with low environmental impact, liquid polybutadiene, which is compatible with EPDM and can improve roll processability by reducing the compound viscosity, and further using a specific amount of a plant-derived component-containing terpene resin for the biomass degree, which is reduced due to the addition of the liquid. The rate of change in biomass degree is less than ±1.5% in comparison to a composition to which liquid polybutadiene and a plant-derived component-containing terpene resin are not added.
An object is to provide a polydimethylsiloxane-containing monomer that exhibits satisfactory compatibility with a hydrophilic monomer and a hydrophilic polymer, in which a polymerization product obtained by polymerizing a composition including the polydimethylsiloxane-containing monomer, the hydrophilic monomer, and the hydrophilic polymer has an anti-lipid adhesion property. It has been recognized that a polydimethylsiloxane-containing monomer having a phosphorylcholine group and a hydroxy group can achieve the object, and thus the present disclosure has been completed.
C08L 83/10 - Block- or graft-copolymers containing polysiloxane sequences
C08G 77/00 - Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon
C08G 77/20 - Polysiloxanes containing silicon bound to unsaturated aliphatic groups
C08G 77/28 - Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen, and oxygen sulfur-containing groups
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
Provided is a hollow fiber membrane module that allows reducing pressure loss of a dry gas and a moist gas. A hollow fiber membrane module has: a hollow fiber membrane bundle; a case in which the hollow fiber membrane bundle is accommodated; a pair of sealing and fixing parts that fixes the hollow fiber membrane bundle to the case; intra-membrane channels; and extra-membrane channels. Moisture in the moist gas is supplied into the dry gas by virtue of the membrane separation effect of the hollow fiber membranes. A first channel is provided, which runs through the case from one end side to the other end side and through which part of the dry gas flows without passing through the intra-membrane channels.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
H01M 8/04119 - Arrangements for control of reactant parameters, e.g. pressure or concentration of gaseous reactants with simultaneous supply or evacuation of electrolyteHumidifying or dehumidifying
Disclosed is an oil agent for cosmetic preparations, the oil agent containing 5-60% by mass of an isoparaffin that has an average number of carbon atoms of 50-250 (component (A)), 30-90% by mass of an isoparaffin that has an average number of carbon atoms of 20-24 (component (B)), and 0.3-10% by mass of an isoparaffin that has 14 carbon atoms or a paraffin (component (C)). The mass ratio ((A)/(C)) of the component (A) to the component (C) is 1-150, and the mass ratio ((B)/(C)) of the component (B) to the component (C) is 5-100.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 1/00 - Make-up preparationsBody powdersPreparations for removing make-up
The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i):
The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i):
The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i):
(in the above-mentioned formula, each symbol is as described in the specification), and a pH-responsive transport carrier which is useful as a transport carrier for safely and efficiently performing delivery of low-molecular-weight drugs and the like to tumor tissues.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
