An amplifier circuit with a high pass filter is constructed to include an operational amplifier (op amp) with a feedback loop in which a capacitor is in parallel with a field effect transistor (FET) configured as a gate tunneling resistor. To configure as a gate tunneling resistor, the source and drain of the FET are tied together, and large resistance is provided through the thin oxide layer between the gate and the source/drain. A bias voltage to the FET can be provided through a separate FET, also configured as a gate tunneling resistor. Additional gate tunneling FETs, also in parallel with the capacitor, can be switched into the circuit in order to provide different resistances, and thus different corner frequencies of the filter. Bias voltages may be supplied by one or more gate tunneling FETs. A fully differential op amp can have complementary feedback loops from its differential outputs, each feedback loop employing one or more gate tunneling FETs.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Computer software and hardware; Computer software and hardware for use in relation to assistive technology; downloadable software as a medical device; downloadable computer software; scientific instrumentation; computer software relating to the medical field; Downloadable computer programs using machine learning; Downloadable computer programs using artificial intelligence; microchips
(2) Surgical and medical devices in relation to assistive technology; medical devices; medical electrodes; medical implants; medical apparatus and instruments, namely microchips, electrodes, and electronics; parts and fittings for all the aforesaid goods (1) Software as a service; Design and development of computer software; design and development of computer software for use with medical technology; medical and scientific research; science and technological services
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Computer software and hardware; downloadable software as a medical device; scientific instrumentation; downloadable computer software; downloadable software for processing and visualising electric signals; computer software relating to the medical field; software applications for use with mobile devices for monitoring and managing patient medical information; medical simulators; Scientific and medical data downloadable via the internet; Computer software for use in medical decision support systems; Downloadable computer programs
(2) Surgical and medical devices; medical electrodes; medical implants for use in the brain; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Computer software and hardware; downloadable software as a medical device; scientific instrumentation; downloadable computer software; downloadable software for processing and visualising neural signals; computer software relating to the medical field; software applications for monitoring and managing patient medical information; medical simulators; Scientific and medical data downloadable via the internet; Computer software for use in medical decision support systems; Downloadable computer programs; chargers; portable chargers; wireless chargers
(2) Surgical and medical devices; medical electrodes; medical implants for use in the brain; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer software and hardware; software as a medical device; scientific instrumentation for measuring, recording, analysing and storing neural signals; downloadable computer software; downloadable software for processing neural signals; computer software relating to the medical field; medical simulators; computer programs using machine learning in the fields of neuroscience; computer programs using artificial intelligence in the fields of neuroscience. Surgical and medical devices; Surgical and medical devices in relation to assistive technology; Surgical and medical devices for neural signal processing; medical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics; electrotherapeutic medical devices; cortical implants; cortical electrodes; parts and fittings for all the aforesaid goods. Software as a service; Design and development of computer software for evaluation and calculation of neural data; design and development of computer software for use with medical technology; design and development of neural data processing software; medical and scientific research in the field of neuroscience; medical and scientific research, namely, research and development in the field of neuroscience; science and technological services, namely research and design in the field of neuroscience research, neural engineering, surgical procedures, medical implant and medical sensor technology.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer software and hardware; Computer software and hardware for use in relation to assistive technology; downloadable software as a medical device; downloadable computer software; scientific instrumentation; computer software relating to the medical field; Downloadable computer programs using machine learning; Downloadable computer programs using artificial intelligence; microchips. Surgical and medical devices in relation to assistive technology; medical devices; medical electrodes; medical implants; Electrodes for medical purposes; parts and fittings for all the aforesaid goods. Software as a service; Design and development of computer software; design and development of computer software for use with medical technology; medical and scientific research; science and technological services.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Computer software and hardware; downloadable software as a medical device; scientific instrumentation; downloadable computer software; downloadable software for processing and visualising neural signals; computer software relating to the medical field; software applications for monitoring and managing patient medical information; medical simulators; Scientific and medical data downloadable via the internet; Computer software for use in medical decision support systems; Downloadable computer programs
(2) Surgical robots; medical robots for use in neurosurgery; medical robots for use in eye surgery; Robotic medical apparatus, for the insertion of implants into the brain; parts and fittings for all the aforesaid goods
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Computer software and hardware; software as a medical device; scientific instrumentation for measuring, recording, analysing and storing neural signals; downloadable computer software; downloadable software for processing neural signals; computer software relating to the medical field; medical simulators; computer programs using machine learning in the fields of neuroscience; computer programs using artificial intelligence in the fields of neuroscience
(2) Surgical and medical devices; Surgical and medical devices in relation to assistive technology; Surgical and medical devices for neural signal processing; medical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics; electrotherapeutic medical devices; cortical implants; cortical electrodes; parts and fittings for all the aforesaid goods (1) Software as a service; Design and development of computer software for evaluation and calculation of neural data; design and development of computer software for use with medical technology; design and development of neural data processing software; medical and scientific research in the field of neuroscience; medical and scientific research, namely, research and development in the field of neuroscience; science and technological services, namely research and design in the field of neuroscience research, neural engineering, surgical procedures, medical implant and medical sensor technology
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded computer software and hardware for use in relation to restoring visual perception; downloadable and recorded software as a medical device for treating neuromuscular and vision disorders; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software for use in relation to restoring visual perception in the fields of neuroscience and vision; medical simulators to simulate prosthetic vision; downloadable and recorded computer programs using machine learning for use in relation to restoring visual perception in the fields of neuroscience and vision; downloadable and recorded computer programs using artificial intelligence for use in relation to restoring visual perception in the fields of neuroscience and vision surgical and medical devices for use in assistive technology in relation to restoring visual perception; surgical and medical devices for use in restoring visual perception; surgical and medical devices for use in restoring visual functions; surgical and medical devices for neural signal processing; medical electrodes; medical implants for use in the brain comprising or primarily comprising artificial material; medical apparatus and instruments, namely, microchips, electrodes, and electronics for processing neural signals; electrotherapeutic medical devices, namely, neurostimulation devices for restoring visual perception; stimulating and recording electrode implants for restoring visual perception comprising or primarily comprising artificial material; cortical implants comprising or primarily comprising artificial material; cortical electrodes for restoring visual perception; systems for restoring visual perception, namely electrodes and stimulators for research and development in the fields of neuroscience and vision for medical use; medical and surgical apparatus, namely, instruments and devices for restoring visual perception; component parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
downloadable and recorded computer software and hardware for use in treating or diagnosing neurological conditions; downloadable and recorded computer software and hardware for use in treating or restoring visual perception; downloadable and recorded computer software and hardware for use in relation to assistive technology and restoration of visual perception; downloadable and recorded computer software and hardware that provides an interface between the brain and computer systems; downloadable and recorded software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing electric signals; downloadable and recorded computer software relating to the medical field for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded software applications for use with mobile devices for monitoring and managing patient medical information; medical simulators for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific and medical data downloadable via the internet; downloadable and recorded computer software for use in medical decision support systems; downloadable computer programs using machine learning in the fields of neuroscience, assistive technology, vision perception and ophthalmology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable computer programs using artificial intelligence in the fields of neuroscience, assistive technology, vision perception and ophthalmology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions surgical and medical devices in relation to assistive technology for use in treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; surgical and medical devices for neural signal processing; medical electrodes; medical implants for use in the brain comprising or primarily comprising artificial material; medical apparatus and instruments, namely, microchips, electrodes, and electronics for processing neural signals; component parts and fittings for all the aforesaid goods, none of the aforesaid goods relating to joint replacement, orthopaedic surgery or artificial limbs Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded computer software and hardware for use in relation to assistive technology; downloadable and recorded computer software and hardware that provides an interface between the brain and computer systems; downloadable software as a medical device; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software relating to the medical field; downloadable and recorded software applications for monitoring and managing patient medical information; medical simulators; scientific and medical data downloadable via the internet; downloadable and recorded computer software for use in medical decision support systems; downloadable computer programs using machine learning in the fields of neuroscience and assistive technology; downloadable computer programs using artificial intelligence in the fields of neuroscience and assistive technology; chargers; portable chargers; wireless chargers Surgical and medical devices in relation to assistive technology; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; surgical and medical devices for neural signal processing; medical electrodes; medical implants for use in the brain; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Downloadable and recorded computer software and hardware for use in relation to assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded computer software and hardware that provides an interface between the brain and computer systems; downloadable software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software relating to the medical field for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded software applications for monitoring and managing patient medical information; medical simulators; scientific and medical data downloadable via the internet; downloadable and recorded computer software for use in medical decision support systems; downloadable computer programs using machine learning in the fields of neuroscience and assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable computer programs using artificial intelligence in the fields of neuroscience and assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions Surgical robots; medical robots for use in neurosurgery; medical robots for use in eye surgery; robotic medical apparatus, for the insertion of implants into the brain; component parts and fittings for all the aforesaid goods
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
downloadable and recorded computer software and hardware for use in relation to assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded computer software and hardware that provides an interface between the brain and computer systems; downloadable software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software relating to the medical field for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices surgical and medical devices in relation to assistive technology for use in treating or diagnosing neurological, psychiatric, and nervous system disorders and conditions; medical devices for use as brain computer interfaces; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain comprising or primarily comprising artificial material; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; component parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded software as a medical device; downloadable and recorded computer software relating to the medical field; downloadable and recorded computer software relating to neurological conditions; downloadable and recorded computer software and hardware for use in relation to restoring visual perception; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software and hardware for use in relation to assistive technology; downloadable and recorded computer software and hardware for use in relation to the treatment and restoration of visual perception; downloadable and recorded computer software and hardware for use in treating or diagnosing neurological conditions; downloadable and recorded computer software and hardware that provides an interface between the brain, computer systems or assistive devices; downloadable software as a medical device; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing electrical and neural signals; downloadable and recorded software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices; downloadable and recorded software applications for monitoring and managing patient medical information; medical simulators; scientific and medical data downloadable via the internet; downloadable and recorded computer software for use in medical decision support systems; downloadable computer programs using machine learning in the fields of neuroscience, assistive technology, vision perception and ophthalmology; downloadable computer programs using artificial intelligence in the fields of neuroscience, assistive technology, vision perception and ophthalmology; chargers; portable chargers; wireless chargers Surgical robots; medical apparatus; medical devices; medical robots for use in neurosurgery; medical apparatus for use in neurosurgery; robotic medical apparatus, for the insertion of implants into the brain; surgical and medical devices in relation to assistive technology; medical devices for use as a brain computer interface; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in restoring visual perception and functions; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain; electrotherapeutic medical devices, namely neurostimulation devices for restoring visual perception; cortical implants; cortical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded computer software relating to the medical field for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded computer software for use in relation to treating, monitoring, and analyzing neurological conditions; downloadable and recorded computer software and hardware for use in relation to restoring visual perception; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software and hardware for use in relation to assistive technology; downloadable and recorded computer software and hardware for use in relation to the treatment and restoration of visual perception; downloadable and recorded computer software and hardware for use in treating or diagnosing neurological conditions; downloadable and recorded computer software and hardware that provides an interface between the brain, computer systems or assistive devices; downloadable software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing electrical and neural signals; downloadable and recorded software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices; downloadable and recorded software applications for monitoring and managing patient medical information; medical simulators for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific and medical data downloadable via the internet; downloadable and recorded computer software for use in medical decision support systems; downloadable computer programs using machine learning in the fields of neuroscience, assistive technology, vision perception and ophthalmology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable computer programs using artificial intelligence in the fields of neuroscience, assistive technology, vision perception and ophthalmology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; battery chargers; portable power chargers; wireless chargers Surgical robots; medical apparatus for use in treating or diagnosing neurological, psychiatric, and nervous system disorders and conditions; medical devices for use in treating or diagnosing neurological, psychiatric, and nervous system disorders and conditions; medical robots for use in neurosurgery; medical apparatus for use in neurosurgery; robotic medical apparatus, for the insertion of implants into the brain; surgical and medical devices in relation to assistive technology for use in treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; medical devices for use as a brain computer interface; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in restoring visual perception and functions; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain comprising or primarily comprising artificial material; electrotherapeutic medical devices, namely neurostimulation devices for restoring visual perception; cortical implants comprising or primarily comprising artificial material; cortical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; component parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable and recorded computer software and hardware for use in relation to assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded computer software and hardware that provides an interface between the brain and computer systems; downloadable software as a medical device for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; scientific instrumentation for measuring, recording, analyzing and storing neural signals; downloadable software for processing and visualizing neural signals; downloadable and recorded computer software relating to the medical field for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable and recorded software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices; downloadable computer programs using machine learning in the fields of neuroscience and assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions; downloadable computer programs using artificial intelligence in the fields of neuroscience and assistive technology for use in relation to treating, monitoring, and analyzing neurological, psychiatric, and nervous system disorders and conditions Surgical and medical devices in relation to assistive technology for use in treating or diagnosing neurological, psychiatric, and nervous system disorders and conditions; medical devices for use as brain computer interfaces; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain comprising or primarily comprising artificial material; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; component parts and fittings for all the aforesaid goods Software as a service (SaaS) services featuring software that provides an interface between the brain and computer systems
A rapid, image processing algorithm for avoiding blood vessels in robotic surgery is disclosed in which a microscopic or other image of a target area is subject to a difference in Gaussians, among other filters, to detect the outlines of vasculature and then segmented. Projections from the borders of each vascular segment are arrayed to determine distances across the blood vessels from different points along the vascular segment. A single diameter is assigned to each vascular segment, and pixels within the segment are associated with the diameter. When a target coordinate is given, any pixel within a certain distance of the coordinate is polled in order to determine if it is part of a blood vessel above a certain size. If it is, then a robotic end effector is halted or redirected.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a medical device; computer software relating to the medical field; computer software relating to neurological conditions; computer software and hardware for use in relation to restoring visual perception; downloadable software for processing and visualising neural signals; Computer software and hardware for use in relation to assistive technology; Computer software and hardware for use in relation to the treatment and restoration of visual perception; Computer software and hardware for use in treating or diagnosing neurological conditions; computer software and hardware that provides an interface between the brain, computer systems or assistive devices; downloadable software as a medical device; scientific instrumentation for measuring, recording, analysing and storing neural signals; downloadable software for processing and visualising electrical and neural signals; software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices; software applications for monitoring and managing patient medical information; medical simulators; Scientific and medical data downloadable via the internet; Computer software for use in medical decision support systems; Downloadable computer programs using machine learning in the fields of neuroscience, assistive technology, vision perception and ophthalmology; Downloadable computer programs using artificial intelligence in the fields of neuroscience, assistive technology, vision perception and ophthalmology; chargers; portable chargers; wireless chargers. Surgical robots; medical apparatus; medical devices; medical robots for use in neurosurgery; medical apparatus for use in neurosurgery; Robotic medical apparatus, for the insertion of implants into the brain; Surgical and medical devices in relation to assistive technology; medical devices for use as a brain computer interface; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in restoring visual perception and functions; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; Surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; Surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain; electrotherapeutic medical devices, namely neurostimulation devices for restoring visual perception; cortical implants; cortical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods. Design and development of computer software for evaluation and calculation of neural and optical data; design and development of computer software for use with medical technology; design and development of neural and optical data processing software; medical and scientific research in the field of neuroscience, assistive technology, vision perception and ophthalmology; medical and scientific research, namely, research and development in the field of neuroscience, assistive technology, vision perception and ophthalmology; science and technological services, namely research and design in the field of neuroscience research, neural engineering, surgical procedures, vision perception, ophthalmology, assistive technology, medical implant and medical sensor technology.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a medical device; computer software relating to the medical field; computer software relating to neurological conditions; computer software and hardware for use in relation to restoring visual perception; downloadable software for processing and visualising neural signals; Computer software and hardware for use in relation to assistive technology; Computer software and hardware for use in relation to the treatment and restoration of visual perception; Computer software and hardware for use in treating or diagnosing neurological conditions; computer software and hardware that provides an interface between the brain, computer systems or assistive devices; downloadable software as a medical device; scientific instrumentation for measuring, recording, analysing and storing neural signals; downloadable software for processing and visualising electrical and neural signals; software applications for use with mobile devices or a computer for monitoring and managing brain computer interface devices; software applications for monitoring and managing patient medical information; medical simulators; Scientific and medical data downloadable via the internet; Computer software for use in medical decision support systems; Downloadable computer programs using machine learning in the fields of neuroscience, assistive technology, vision perception and ophthalmology; Downloadable computer programs using artificial intelligence in the fields of neuroscience, assistive technology, vision perception and ophthalmology; chargers; portable chargers; wireless chargers. Surgical robots; medical apparatus; medical devices; medical robots for use in neurosurgery; medical apparatus for use in neurosurgery; Robotic medical apparatus, for the insertion of implants into the brain; Surgical and medical devices in relation to assistive technology; medical devices for use as a brain computer interface; surgical and medical devices for use in medical treatment of physical paralysis; surgical and medical devices for use in restoring visual perception and functions; surgical devices for implanting brain computer interface and cortical implants; medical devices for use in facilitating communication and control of software and hardware; medical devices namely, an implantable brain to computer interface for facilitating communication and control of software and hardware; Surgical and medical devices for use in facilitating communication, movement, sensory and visual functions; Surgical and medical devices namely, an implantable brain to computer interface for restoring communication, movement, sensory and visual functions; medical devices for neural signal processing; medical electrodes; medical implants for use in the brain; electrotherapeutic medical devices, namely neurostimulation devices for restoring visual perception; cortical implants; cortical electrodes; medical apparatus and instruments, namely microchips, electrodes, and electronics for processing neural signals; parts and fittings for all the aforesaid goods. Design and development of computer software for evaluation and calculation of neural and optical data; design and development of computer software for use with medical technology; design and development of neural and optical data processing software; medical and scientific research in the field of neuroscience, assistive technology, vision perception and ophthalmology; medical and scientific research, namely, research and development in the field of neuroscience, assistive technology, vision perception and ophthalmology; science and technological services, namely research and design in the field of neuroscience research, neural engineering, surgical procedures, vision perception, ophthalmology, assistive technology, medical implant and medical sensor technology.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
25 - Clothing; footwear; headgear
Goods & Services
Medical devices, namely, invasive devices, for use in
treating or diagnosing neurological conditions. Mugs and water bottles sold empty. Clothing, namely, shirts and jackets; hats.
Systems and methods confirm a wireless pairing between an implanted device, such as a neural implant, and an external device, such as a computer or mobile device. The implanted device receives signals from the external device, which may be a varying magnetic field or a set of neural signals. The implanted device decodes the signals to identify a pairing code. Based on determining the pairing code, the implanted device may use this to perform a method of pairing which is not vulnerable to man-in-the-middle attacks. Alternatively, the implanted device can securely provide a pairing code to a helper device which can surface the pairing code to the user for confirmation.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
25 - Clothing; footwear; headgear
Goods & Services
Medical devices, namely, invasive devices, for use in
treating or diagnosing neurological conditions. Mugs and water bottles sold empty. Clothing, namely, shirts and jackets; hats.
23.
DIE RECONSTITUTION AND HIGH-DENSITY INTERCONNECTS FOR EMBEDDED CHIPS
Methods of manufacturing a sealed electrical device for embedded integrated circuit (IC) chips are described, as well as the resulting devices themselves. The sealed electrical device is created by removing material from a substrate to form a pocket in the substrate. An unencapsulated, or bare, IC chip can be placed within the pocket with connection pads of the IC chip facing outward. A gap between the IC chip and a side of the pocket can be filled with a filler. An uncured polymer can be cast over the substrate, which can be allowed to cure into a flat polymer sheet. Conductive traces can be patterned on the polymer sheet and to the connection pads of the IC chip. The conductive traces can then be coated with polymer to form a ribbon cable. Substrate can then be removed from underneath the ribbon cable, leaving substrate around the pocket to protect the IC chip.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
25 - Clothing; footwear; headgear
Goods & Services
(1) Medical devices, namely, invasive devices, for use in treating or diagnosing neurological conditions.
(2) Mugs and water bottles sold empty.
(3) Clothing, namely, shirts and jackets; hats.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
25 - Clothing; footwear; headgear
Goods & Services
(1) Medical devices, namely, invasive devices, for use in treating or diagnosing neurological conditions.
(2) Mugs and water bottles sold empty.
(3) Clothing, namely, shirts and jackets; hats.
26.
Dicing and partial dicing release of lithographed device
The disclosure provides a method for fabricating a cantilever section in a structure, which includes providing a structure comprising a substrate, a compliant layer and a sacrificial layer therebetween; cutting part-way through the substrate to create an at least one linear partial cut; releasing the sacrificial layer from the structure; and breaking the substrate along the at least one linear partial cut to generate a cantilever section in a substrate.
B32B 38/00 - Ancillary operations in connection with laminating processes
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
B32B 27/28 - Layered products essentially comprising synthetic resin comprising copolymers of synthetic resins not wholly covered by any one of the following subgroups
Systems and methods are disclosed for a lead, needle, and cannula that are sized and shaped for ease of needle threading and positioning, e.g., for implanting the lead into biological tissue. The lead has an opening at one end surrounded by an expanded region. The needle has a ledge in a side of the needle. The cannula has an exit gate with an aperture sized to accept the expanded region of the lead. A portion of the needle is held inside the cannula and can extend or retract therein. When the expanded region of the lead is threaded through the exit gate aperture, the needle is configured to extend through the opening of the lead and catch the lead on the ledge. The needle is further configured to extend past the exit gate of the cannula while pulling the lead through the slot and free of the aperture.
Techniques for compressing neural signals are disclosed herein. The neural signal compression techniques can include lossless compression, lossy compression, binned spike compression, and spike-band power compression. Lossless compression can compress neural signals using a difference predictor to encode compressed neural signals via binary and unary coding. Lossy compression can compress neural signals using quantized wavelet transforms to generate an encoded bit-stream of compressed neural signals. Binned spike and spike-band power compression can leverage the sparse nature of neural signals to threshold the neural signals for generating an appended bit-stream of compressed neural signals.
Techniques for static and dynamic input multiplexing for high-density neural signal recording are disclosed herein. A multiplexer can receive a first set of neural signals via inputs. A subset of the first set of neural signals above a threshold can be determined. A group of the inputs corresponding to the subset of the first set of neural signals can be determined. Operation of the multiplexer can be modified to block inputs not in the identified group of the inputs. A second set of neural signals can be received into the multiplexer via the group of the inputs. The second set of neural signals can be transmitted to a plurality of channels of an amplifier while blocking inputs not in the identified group of the inputs. The second set of neural signals can be amplified using the amplifier. The amplified second set of neural signals can be transmitted for further processing.
Techniques for static and dynamic input multiplexing for high-density neural signal recording are disclosed herein. A multiplexer can receive a first set of neural signals via inputs. A subset of the first set of neural signals above a threshold can be determined. A group of the inputs corresponding to the subset of the first set of neural signals can be determined. Operation of the multiplexer can be modified to block inputs not in the identified group of the inputs. A second set of neural signals can be received into the multiplexer via the group of the inputs. The second set of neural signals can be transmitted to a plurality of channels of an amplifier while blocking inputs not in the identified group of the inputs. The second set of neural signals can be amplified using the amplifier. The amplified second set of neural signals can be transmitted for further processing.
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G06F 16/28 - Databases characterised by their database models, e.g. relational or object models
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
31.
Capacitive shield for charger artifact reduction for implants
A set of shielded coils for wireless power transmission into a medical implant is described in which the external, power transmission coil is blocked at least on one side by a shield with a broken ring and radial fingers while the power receiver coil inside the medical implant is surrounded by a shield having a broken ring connecting radial fingers and ribs around its circumference. The finger and rib configurations minimizes eddy currents in the shields. A ground plane of the implant's internal circuitry, which is within the shield along with the receiver coil, can cap off the cupped receiver shield to form a Faraday cage with it. The metal or other conductive shielding prevents large electric fields from the coils from penetrating into the tissue of the subject while simultaneously allowing magnetic fields inductively couple the coils for charging. An implant with sensitive electrodes that measure minute voltages from a brain or other tissues is protected from capacitively driven voltage swings or other transients during charging.
H02J 50/70 - Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields
A61N 1/372 - Arrangements in connection with the implantation of stimulators
Disclosed is a craniotomy milling system, which includes a computer numerical milling machine having a spindle configured to be positioned relative to a craniotomy location of a cranium of a patient and an end mill. The craniotomy milling system includes a controller for controlling the feed rate of the end mill. The craniotomy milling system includes an impedance measurement system and an axial force sensor. The craniotomy milling system includes a processor electrically coupled with a controller, the impedance measurement system, and the axial force sensor. The processor is configured to send a signal to the controller to change the feed rate of the end mill in response to a change in impedance or a change in axial force.
A61B 17/16 - Instruments for performing osteoclasisDrills or chisels for bonesTrepans
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G05B 19/18 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
The disclosure provides a soak tester apparatus for testing an implantable enclosure having an impedance engine, a multiplexer and a removably attached cartridge, which cartridge has a plurality of threads, comprising a Faraday cage housing; a receptacle disposed within the Faraday cage housing, wherein the receptacle is configured to host an implantable enclosure having an impedance engine, a multiplexer and a removably attached cartridge, which cartridge has a plurality of threads; and a pigtail disposed within the Faraday cage housing having a charging coil configured to power the implantable enclosure.
Disclosed is a brain implant placement apparatus, which includes a base member contoured to rest against a cranium of a patient. The brain implant apparatus including a pivot arm hingedly coupled to the base member and configured to rotate from a first configuration to a second configuration. The brain implant placement apparatus including an implant attachment member coupled to the pivot arm via a rotating attachment mechanism and further comprising a receiving portion configured to removably couple with a brain implant and rotate the brain implant. In the first configuration, the pivot arm is positioned such that the receiving portion of the implant attachment member is facing upward. In the second configuration, the pivot arm is positioned such that the receiving portion of the implant attachment member is facing substantially downwards.
An implantable device and method of manufacture include a substantially hermetic polychlorotrifluoroethylene (PCTFE) enclosure with closely-spaced wires extending out of the enclosure. The implantable device includes a PCTFE first portion of an enclosure and a PCTFE second portion of the enclosure. The first and second portions are configured to mate with each other to form the enclosure. A plurality of insulated wires extend between the first and second portions of the enclosure. Each of the insulated wires are parallel to each other and separated by less than 150 micrometers (μm) from a neighboring wire. A thermal weld seam of PCTFE is disposed between the first portion of the enclosure and the second portion of the enclosure and conformally adheres around insulation of each wire such that the enclosure is sealed.
H01L 23/08 - ContainersSeals characterised by the material of the container or its electrical properties the material being an electrical insulator, e.g. glass
H01B 3/30 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes
H01L 21/52 - Mounting semiconductor bodies in containers
36.
POLYMER ENCLOSURE WITH WIRE PASSTHROUGH FOR IMPLANTABLE DEVICE
An implantable device and method of manufacture include a substantially hermetic polychlorotrifluoroethylene (PCTFE) enclosure with closely-spaced wires extending through a slit in the enclosure. A method for manufacturing the implantable device includes cutting a slit in a piece of polymer and extending a plurality of insulated wires through the slit. Each of the insulated wires are parallel to a neighboring wire of the insulated wires. The piece of polymer is thermally bonded around each wire of the plurality of insulated wires such that the piece of polymer is sealed around insulation of each wire with a portion of each wire extending through the piece of polymer.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
H01B 3/30 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes
H01B 7/04 - Flexible cables, conductors, or cords, e.g. trailing cables
Accelerated testing apparatuses for implants are described, as well as methods for accelerated testing implants. The accelerated testing apparatus includes a cabinet having multiple bays and a vessel insertable and removable from any of the multiple bays. The vessel includes a watertight basin, a radio-frequency (RF) transparent lid configured to mate with the basin, and a plurality of fixtures within the vessel. Each fixture is adapted to anchor a device-under-test while submersed within the vessel. The accelerated testing apparatus also includes a reservoir disposed within the cabinet, a heater connected with the reservoir, a pump configured to circulate liquid between the reservoir and the vessel, an antenna within the cabinet for communication with the device-under-test, and at least one computer server operatively connected with the antenna.
G01R 31/00 - Arrangements for testing electric propertiesArrangements for locating electric faultsArrangements for electrical testing characterised by what is being tested not provided for elsewhere
A coil formed from a flexible polymer substrate that is printed with metal traces is disclosed in which the flexible substrate has notches that align each loop as the substrate is wound into a ring. The notches are precisely spaced so that the diameter of each loop is well controlled. As the substrate is wound, adhesive is applied along its length to fill gaps between each loop's layer. Ideally, the adhesive has a similar dielectric constant as the polymer substrate. The resulting coil has loops of metal traces separated by precise a thickness of dielectric. The precision in spacing between metal layers and dielectric allows the coil to be designed for self-resonance.
Methods involving interpreting signals from a brain-machine interface (BMI) are described, as well as methods involving adjusting an implanted or wearable BMI device. The method includes receiving neural signals from a brain of a subject into a BMI decoder. The method includes determining an activity change of the subject based on a sensor. The method includes routing the neural signals from a first model to a second model in the BMI decoder based on the determined activity change. The method includes translating, using the second model in the BMI decoder, the neural signals into a command. The method includes sending the command to a controller.
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06F 3/0484 - Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
The disclosure provides a biological brain-computer interface comprising genetically modified cells engrafted onto an adult mammal (e.g., mouse) above cortical layer 1, forming an artificial cortical layer termed layer zero (L0). Following engraftment, L0 goes through a developmental process characterized by synchronous waves of activity that gradually recede to resemble spontaneous cortical activity. Axons and dendrites from L0 nondestructively infiltrated the host cortex and formed synaptic connections necessary for bidirectional communication with the brain.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The disclosure provides a biological brain-computer interface comprising genetically modified cells engrafted onto an adult mammal (e.g., mouse) above cortical layer 1, forming an artificial cortical layer termed layer zero (L0). Following engraftment, L0 goes through a developmental process characterized by synchronous waves of activity that gradually recede to resemble spontaneous cortical activity. Axons and dendrites from L0 nondestructively infiltrated the host cortex and formed synaptic connections necessary for bidirectional communication with the brain.
Methods and systems of using a laser beam to weld an object with a non-flat surface, including curved surfaces, are described, where at least one piece of the object is transparent. An optical guide with a flat surface and an interface surface is placed on a piece of an object to welded. The interface surface is fabricated to form-fit the non-flat surface of the object to be welded, and is opposite the flat surface. A liquid optical medium is applied between the non-flat surface and the interface surface, filling any gaps or surface defects. The laser beam is then transmitted through the optical guide, liquid optical medium, and into the object to be welded, to a location to be welded. The laser beam then welds the object to be welded at pre-determined points.
A space-saving configuration for electronics is disclosed in which at least four circuit boards are arranged to form sides of a five-or-greater sided geometric prism that are perpendicular to a common plane. That is, they are stood up on their sides and connected with flex cable to approximate a cylinder. Each circuit board can include one or more sides with electrical components. The circuit boards make up at least half of the five-or-greater sided geometric prism such that the circuit boards wrap at least halfway around. A common connector on one of the circuit boards can be configured to receive power from an underlying motherboard, and flex cables connecting adjacent circuit boards in series distribute power received from the connector to each of the circuit boards in series.
A three-level encoding transmitter is disclosed in which a transmitter circuit is configured to receive an input data signal including binary data and transmit an encoded data signal. The transmitter circuit can include an inverter circuit configured transmit first and second voltages for each logical level of the binary data. A transmission control circuit can cause the inverter circuit to transmit the voltages or deactivate the inverter circuit based on a first control signal. The transmitter circuit can further include an idle circuit configured to transmit an idle voltage between the first and second voltages when there is no data transmission. The idle circuit may transmit the idle voltage based on a second control signal. The first and second control signals may be configured to only be active when the other is inactive.
The embodiments disclosed herein relate to chips used to receive and process neurological events in brain matter as captured by electrodes. Such chips may include an array of amplifiers and electrodes to receive neurological voltage signals, the chip including a config circuitry in communication with the array of amplifiers and a controller, the config circuitry configured to receive program instructions and instruct the amplifiers of a voltage threshold and instruct the controller to pass on signals from only specific rows and columns of amplifiers, the controller in communication with the array of amplifiers, the controller configured to packetize the neurological voltage signals into data packets.
Disclosed are methods related to guiding robotic surgery using optical coherence tomography (OCT) and computer-readable media and computer systems executing the methods. They may include receiving a series of cross-sectional slices of 3D space obtained from an OCT probe over biological tissue and processing and filtering the series of slices. The processing and filtering may include spatially smoothing the intensity values of each slice, thresholding each slice after it has been blurred, performing a connected-component analysis to identify blobs on the thresholded slice, filtering the blobs, performing edge detection, and invoking a selective median filter. The processing and filtering can be used to construct a depth map from the received series of cross-sectional slices in order to guide a robotic end effector, based on the depth map.
A61B 19/00 - Instruments, implements or accessories for surgery or diagnosis not covered by any of the groups A61B 1/00-A61B 18/00, e.g. for stereotaxis, sterile operation, luxation treatment, wound edge protectors(protective face masks A41D 13/11; surgeons' or patients' gowns or dresses A41D 13/12; devices for carrying-off, for treatment of, or for carrying-over, body liquids A61M 1/00)
A method is described for real-time detecting and classifying of a characteristic signal, such as a neural spike, and forwarding information for further processing if it meets certain criteria. A system (e.g., an on-chip system implanted in a subject's cranium with limited processing power) receives an electrical biological signal. The system filters the signal to generate a filtered signal and fits the filtered signal to a model. The system identifies a set of fit values based on the model, the set of fit values comprising a plurality of sample amplitude values and a respective plurality of time values. Based on the fit values, the system computes a set of characteristic values. The system compares the characteristic values to a corresponding set of threshold values. Based on the comparison, the system determines whether the received biological signal corresponds to a neural spike and, if a spike is detected, forwards on information.
Methods of manufacturing a biocompatible, hermetic feedthrough monolithically integrated with a biocompatible ribbon cable are described, as well as the resulting devices themselves. The hermetic feedthrough is created by placing glass over a mold of doped silicon or other material with a higher melting temperature than the glass and heating it to reflow the glass into the mold. The glass is then ground or otherwise removed to reveal a flat surface, and tiny pillars that were in the mold are isolated in the glass to form electrically conductive vias. The flat surface is used to cast a polymer and build up a ribbon cable, photolithographically or otherwise, that is monolithically attached to the vias.
A brain-machine interface (BMI) is described in which many flexible electrodes for implanting within a subject's brain run to a cylindrical sensor device configured to fit inside a burr hole in the cranium. The devices contain sealed electronics that convert analog neural voltages to digital signals, or vice versa, and connects through a serial cable to a subcutaneous relay on the mastoid region (behind the subject's ear) or other suitable location. The relay draws power from and communicates with an externally worn device and distributes the power to the devices. The externally worn device communicates wirelessly or through a tether to a base station computer for data analysis and/or stimulation.
Disclosed is a sandwich assembly containing a thin film electrode array for use with high density electrodes. To minimize the volume required by the associated electronics, the electrode array and integrated circuits are sandwiched over a Printed Circuit Board (PCB), which may have other integrated circuits on an opposite side. Among other things, the disclosed apparatus, system, and method improve over previous systems by providing holes and vias that facilitate communication between a custom chip above the PCB and a field-programmable gate array (FPGA) below. The thin film electrode array can be fastened by bucking a pillar of stacked gold or other metal balls to rivet, the thin film flex circuit. The system can include a thin film array having embedded wire traces and holes, a PCB having vias aligned with the holes, chips including an analog-to-digital converter (ADC) sandwiching the thin film, and solder connections from the chips through the holes to the vias.
Disclosed are methods related to guiding robotic surgery using optical coherence tomography (OCT) and computer-readable media and computer systems executing the methods. They may include receiving a series of cross-sectional slices of 3D space obtained from an OCT probe over biological tissue and processing and filtering the series of slices. The processing and filtering may include spatially smoothing the intensity values of each slice, thresholding each slice after it has been blurred, performing a connected-component analysis to identify blobs on the thresholded slice, filtering the blobs, performing edge detection, and invoking a selective median filter. The processing and filtering can be used to construct a depth map from the received series of cross-sectional slices in order to guide a robotic end effector, based on the depth map.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
A61B 90/30 - Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
Methods of manufacturing a biocompatible, hermetic feedthrough monolithically integrated with a biocompatible ribbon cable are described, as well as the resulting devices themselves. The hermetic feedthrough is created by placing glass over a mold of doped silicon or other material with a higher melting temperature than the glass and heating it to reflow the glass into the mold. The glass is then ground or otherwise removed to reveal a flat surface, and tiny pillars that were in the mold are isolated in the glass to form electrically conductive vias. The flat surface is used to cast a polymer and build up a ribbon cable, photolithographically or otherwise, that is monolithically attached to the vias.
H01L 23/043 - ContainersSeals characterised by the shape the container being a hollow construction and having a conductive base as a mounting as well as a lead for the semiconductor body
H01L 23/00 - Details of semiconductor or other solid state devices
C03C 19/00 - Surface treatment of glass, not in the form of fibres or filaments, by mechanical means
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
H01L 21/60 - Attaching leads or other conductive members, to be used for carrying current to or from the device in operation
A method is described for real-time detecting and classifying of a characteristic signal, such as a neural spike, and forwarding information for further processing if it meets certain criteria. A system (e.g., an on-chip system implanted in a subject's cranium with limited processing power) receives an electrical biological signal. The system filters the signal to generate a filtered signal and fits the filtered signal to a model. The system identifies a set of fit values based on the model, the set of fit values comprising a plurality of sample amplitude values and a respective plurality of time values. Based on the fit values, the system computes a set of characteristic values. The system compares the characteristic values to a corresponding set of threshold values. Based on the comparison, the system determines whether the received biological signal corresponds to a neural spike and, if a spike is detected, forwards on information.
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G06F 16/28 - Databases characterised by their database models, e.g. relational or object models
The embodiments disclosed herein relate to chips used to receive and process neurological events in brain matter as captured by electrodes. Such chips may include an array of amplifiers and electrodes to receive neurological voltage signals, the chip including a config circuitry in communication with the array of amplifiers and a controller, the config circuitry configured to receive program instructions and instruct the amplifiers of a voltage threshold and instruct the controller to pass on signals from only specific rows and columns of amplifiers, the controller in communication with the array of amplifiers, the controller configured to packetize the neurological voltage signals into data packets.
The disclosure provides an apparatus and methods for performing a piotomy on a mammal comprising: performing a craniotomy to remove the skull and expose dura mater; removing the dura mater and arachnoid mater to expose subarachnoid space; and performing a piotomy using a laser to create a hole and expose the cerebral cortex.
A61B 18/20 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
A61B 18/00 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
56.
Sandwich assembly scheme for thin film electrode array and integrated circuits on both sides of printed circuit board (PCB) and method of manufacture
Disclosed is a sandwich assembly containing a thin film electrode array for use with high density electrodes. To minimize the volume required by the associated electronics, the electrode array and integrated circuits are sandwiched over a Printed Circuit Board (PCB), which may have other integrated circuits on an opposite side. Among other things, the disclosed apparatus, system, and method improve over previous systems by providing holes and vias that facilitate communication between a custom chip above the PCB and a field-programmable gate array (FPGA) below. The thin film electrode array can be fastened by bucking a pillar of stacked gold or other metal balls to rivet the thin film flex circuit. The system can include a thin film array having embedded wire traces and holes, a PCB having vias aligned with the holes, chips including an analog-to-digital converter (ADC) sandwiching the thin film, and solder connections from the chips through the holes to the vias.
H01L 23/00 - Details of semiconductor or other solid state devices
A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
H01L 23/48 - Arrangements for conducting electric current to or from the solid state body in operation, e.g. leads or terminal arrangements
A system and method for implanting devices into biological tissue (e.g., brain tissue). The system may include a biocompatible probe, an integrated circuit (IC) chip tethered to the probe, a cartridge comprising a temporary attachment surface by which the probe is removably coupled to the cartridge and a fastener for removably coupling the IC chip to the cartridge, a needle to reversibly engage with the probe, a robotic arm to hold the needle, a camera, and a microprocessor controller. The microprocessor controller may control the robotic arm and the needle using the to remove the probe from the temporary attachment surface using the needle, pierce the biological tissue with the needle and the probe, withdraw the needle while leaving the probe within the biological tissue; and detach the IC chip from the cartridge, leaving the IC chip with the biological tissue, the IC chip still tethered to the probe
Disclosed are biocompatible multi-electrode devices capable of being implanted in sensitive tissue, such as the brain, and methods for fabricating such arrays. The disclosed arrays can be implanted in living biological tissue with a single needle insertion. The devices can include linear arrays with contacts along an edge, linear arrays with multiple electrodes per opening in a parylene support layer, multi-thread electrode arrays, tree-like electrode arrays, and combinations thereof. In an embodiment, a compliant electrode apparatus can comprise a biocompatible and bio-implantable compliant dielectric having a top edge defined by a top and a side along a length of the dielectric, insulated electrical traces oriented along the length of the dielectric, and electrode contacts coupled to the traces and situated on the side along the length of the dielectric, wherein an exposed portion of a respective electrode contact protrudes beyond the top edge of the dielectric.
Disclosed are biocompatible multi-electrode devices capable of being implanted in sensitive tissue, such as the brain, and methods for fabricating such arrays. The disclosed arrays can be implanted in living biological tissue with a single needle insertion. The devices can include linear arrays with contacts along an edge, linear arrays with multiple electrodes per opening in a parylene support layer, multi-thread electrode arrays, tree-like electrode arrays, and combinations thereof. In an embodiment, a compliant electrode apparatus can comprise a biocompatible and bio-implantable compliant dielectric having a top edge defined by a top and a side along a length of the dielectric, insulated electrical traces oriented along the length of the dielectric, and electrode contacts coupled to the traces and situated on the side along the length of the dielectric, wherein an exposed portion of a respective electrode contact protrudes beyond the top edge of the dielectric.
Systems and methods that use computer vision techniques in connection with robotic surgery are discussed. A robotic surgery system may include an implantable device engagement sub-system, a targeting sub-system, and/or an insertion verification sub-system. The system may use computer vision techniques to facilitate implanting a micro-manufactured bio-compatible electrode device in biological tissue (e.g., neurological tissue such as the brain) using robotic assemblies. The system can attach, via robotic manipulation, the electrode to an engagement element of an insertion needle. The system can further irradiate the electrode using a near-ultraviolet (near-UV) wavelength of light, obtain images of the electrode with light fluoresced from the polymer portion in response to the irradiating, triangulate a 3D location of the electrode, analyze a target tissue contour using computer vision, select an insertion site, and surgically implant the micron-scale electrode at the insertion site via robotic assembly and based on the triangulated location.
A system and method for implanting devices into biological tissue (e.g., brain tissue). The system may include a biocompatible probe, an integrated circuit (IC) chip tethered to the probe, a cartridge comprising a temporary attachment surface by which the probe is removably coupled to the cartridge and a fastener for removably coupling the IC chip to the cartridge, a needle to reversibly engage with the probe, a robotic arm to hold the needle, a camera, and a microprocessor controller. The microprocessor controller may control the robotic arm and the needle using the to remove the probe from the temporary attachment surface using the needle, pierce the biological tissue with the needle and the probe, withdraw the needle while leaving the probe within the biological tissue; and detach the IC chip from the cartridge, leaving the IC chip with the biological tissue, the IC chip still tethered to the probe.
A61B 17/00 - Surgical instruments, devices or methods
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
Systems and methods that use computer vision techniques in connection with robotic surgery are discussed. A robotic surgery system may 'include an implantable device engagement sub-system, a targeting sub-system, and/or an insertion verification sub-system. The system may use computer vision techniques to facilitate implanting a micro-manufactured bio-compatible electrode device in biological tissue (e.g., neurological tissue such as the brain) using robotic assemblies. The system can attach, via robotic manipulation, the electrode to an engagement element of an insertion needle. The system can further irradiate the electrode using a near-ultraviolet (near-UV) wavelength of light, obtain images of the electrode with light fluoresced from the polymer portion in response to the irradiating, triangulate a 3D location of the electrode, analyze a target tissue contour using computer vision, select an insertion site, and surgically implant the micron-scale electrode at the insertion site via robotic assembly and based on the triangulated location.
The embodiments disclosed herein relate to chips used to receive and process neurological events in brain matter as captured by electrodes. Such chips may include an array of amplifiers and electrodes to receive neurological voltage signals, the chip including a config circuitry in communication with the array of amplifiers and a controller, the config circuitry configured to receive program instructions and instruct the amplifiers of a voltage threshold and instruct the controller to pass on signals from only specific rows and columns of amplifiers, the controller in communication with the array of amplifiers, the controller configured to packetize the neurological voltage signals into data packets.
21 - HouseHold or kitchen utensils, containers and materials; glassware; porcelain; earthenware
25 - Clothing; footwear; headgear
Goods & Services
Medical devices, namely, invasive devices, for use in treating or diagnosing neurological conditions. Mugs and water bottles sold empty. Clothing, namely, shirts and jackets; hats.
