Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.
Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.
C07C 323/65 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 239/26 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.
C07C 323/65 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
C07D 239/26 - Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 261/08 - Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/501 - PyridazinesHydrogenated pyridazines not condensed and containing further heterocyclic rings
A61K 31/535 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
122 are as defined herein, and pharmaceutical compositions comprising these organosulfur compounds. Uses of the organosulfur compounds and the pharmaceutical compositions for treating infection and/or for treating inflammation and/or for reducing the formation of blood clots.
C07C 323/65 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
C07D 307/38 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
C07D 333/18 - Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
The present invention relates to the ability of vinyldithiins, analogues and derivatives thereof to regulate sodium absorption and fluid homeostasis and to treat of disorders with symptoms related to elevated sodium transport and difficulties associated with mucociliary clearance. The invention provides pharmaceutical compositions comprising vinyldithiins, analogues and derivatives thereof, for reducing sodium ion uptake in cells, by modulating activity of an epithelial sodium channel (ENaC) and/or Na+/K+-ATPase solute pump.
The present invention relates to the use of ajoene, analogues and derivatives thereof to regulate sodium absorption and fluid homeostasis and to treat disorders with symptoms related to elevated sodium transport and difficulties associated with mucociliary clearance. The invention provides pharmaceutical compositions comprising ajoene or an analogue or derivative thereof, for reducing sodium ion uptake in cells. This may be achieved by modulating the activity of an epithelial sodium channel (ENa C) and/or a Na+/K+ - ATPase.
The present invention provides an antimicrobial composition comprising honey and ajoene for use in treating or preventing a skin and/or wound infection in a subject. Methods for treating or preventing a skin and/or wound infection, comprising administering a therapeutically or prophylactically effective amount of an antimicrobial composition comprising honey and ajoene to a subject in need thereof are also described.
05 - Pharmaceutical, veterinary and sanitary products
31 - Agricultural products; live animals
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations; veterinary preparations; nutraceutical preparations; dietetic food for medical or healthcare purposes; dietetic beverages for medical or healthcare purposes; dietetic substances for healthcare or medical purposes; chemical preparations for medical, pharmaceutical and/or veterinary purposes; biological preparation for medical, pharmaceutical and/or veterinary purposes; chemico-pharmaceutical preparations; chemical preparations to treat mildew, wheat blight and/or wheat smut; nutritional supplements; nutraceutical supplements; food supplements; dietary supplements; health food supplements made from plant extracts; plant extracts for pharmaceutical use; plant extracts for nutraceutical use; plant extracts for dietetic use; plant extracts for medical use; plant extracts for nutritional purposes; acaricides; algicides; alginate dietary supplements for pharmaceutical purposes; amino acids for medical purposes; amino acids for veterinary purposes; enzyme preparations for medical purposes; enzymes preparations for veterinary purposes; anthelmintics; antibiotics; antiparasitic preparations; appetite suppressants for medical purposes; drugs for medical purposes; herbal teas for medical purposes; enzymes for medical purposes; fumigation preparations for medical purposes; enzyme dietary supplements; enzymes preparations for pharmaceutical purposes; yeast dietary supplements; yeast for pharmaceutical purposes; dietary fiber; bacterial poisons; biocides; by-products of the processing of cereals for dietetic and/or medical purposes; lotions for pharmaceutical purposes; lotions for veterinary purposes; meal for pharmaceutical purposes; sanitary preparations for medical purposes; dietetic substances adapted for food for babies; plasters, material for dressings; material for stopping teeth, dental wax; medicines for dental purposes; medicines for human; medicines for veterinary purposes; mouthwashes for medical purposes; porcelain for dental prostheses; disinfectants; preparations for destroying dry rot fungus and/or vermin; fungicides; herbicides; medicinal herbs and infusions; insect repellents; insecticides; parasiticides; pesticides. Agricultural, horticultural and/or forestry products not included in other classes; grains not included in other classes; fresh fruits; fresh vegetables; seeds; natural plants; natural flowers; foodstuffs for animals; algae for human or animal consumption; weeds for human or animal consumption; pet food; fruit residue; additive to animal feed not for medical purposes; animal feed not for medical purposes; animal and/or livestock fattening preparations; edible chews for animals; by-products of the processing of cereals, for animal consumption; cattle cake; cattle food; grains for human or animal consumption; wheat germ and/or yeast for animal consumption; meal for animals; stall food for animals; mash for fattening livestock; strengthening animal forage. Scientific services for scientific research; technological services for scientific research; technical research; scientific laboratory services; bacteriological research; biological research; chemical analysis; chemical research; cosmetic research; chemistry services; research and/or development in the bio-pharmaceutical and/or nutraceutical field; collection and analysis of data in the bio-pharmaceutical and/or nutraceutical field; research in the bio-pharmaceutical and/or nutraceutical field; provision of scientific and/or technical information in the bio-pharmceutical and/or nutraceutical field; provision of consultancy services in the bio-pharmaceutical and/or nutraceutical field.
The present invention provides an antimicrobial composition comprising at least one garlic extract and one or more of a bioflavonoid and/or an organic acid as well as the use of the same for treating or preventing bacterial, fungal or parasitic infections.
A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
A61K 31/255 - Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
The present invention relates to a process for producing ajoene from allicin via a polymeric substrate, comprising the steps of heating allicin or an allicin solution at a predetermined temperature range such that at least a portion of the allicin is converted to ajoene to form an ajoene solution; and separating the ajoene from the ajoene solution; wherein at least one of the heating or separating steps is conducted via a polymeric substrate. The process for producing ajoene from allicin via a polymeric substrate further comprises a step of retaining the allicin or the allicin solution on the polymeric substrate before the heating step is conducted within or out of the polymeric substrate. The present invention also relates to ajoene or a composition comprising ajoene obtained by the process thereof.
C07C 319/24 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
C07C 323/65 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
The present invention is directed to a process for the preparation of ajoene which comprises the step of heating an acidic solution comprising allicin, and to ajoene which may be prepared by this process. The invention also relates to processes for the preparation of allicin in which (1) allinase plant source is mechanically treated, the product is subjected to centrifugal forces and the solution of allinase thus prepared is contacted with an aqueous solution of aliin; or (2) a solution comprising diallyl disulphide is oxidised in the presence of potassium peroxomonosulphonate at 0 to 30 °C and the resulting allicin is extracted into an organic solvent. Additionally, the invention relates to a process for increasing the concentration of allicin in an aqueous solution by freezing the aqueous solution.
C07C 319/22 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
C07C 323/65 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
C12P 11/00 - Preparation of sulfur-containing organic compounds
