Various aspects of this patent document relate to a method to extract an oil from a plant material using an apparatus by first exposing the plant material to a heated gas stream at a temperature sufficient to volatilize the oil from the plant material, and then rapidly cooling the gas stream to liquefy the oil.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
Various aspects of this disclosure relate to the simultaneous production and distillation of furfural, 5-(hydroxymethyl)furfural, 5-methylfufural, guaiacol, eugenol, vanillin, 2-methoxy-3-methylphenol, 2-methoxy-4-methylphenol, 2-methoxy-5-methylphenol, syringol, syringaldehyde, 2,6-dimethoxy-3-methylphenol, 2,6-dimethoxy-4-methylphenol, 2,6-dimethylphenol, and/or 2,6-dimethoxy-4-(prop-2-enyl)phenol to produce a distillate comprising one or more of the aforementioned molecules. In selected embodiments, the distillate is produced from a natural product and replicates the flavor and/or aroma of the natural product.
Various aspects of this patent document relate to liquid compositions comprising cannabidiol, which have either freezing points or glass-liquid transition temperatures less than the melting point of pure cannabidiol.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A24B 15/167 - Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
A61K 31/00 - Medicinal preparations containing organic active ingredients
Various aspects of this disclosure relate to the simultaneous production and distillation of furfural, 5-(hydroxymethyl)furfural, 5-methylfufural, guaiacol, eugenol, vanillin, 2-methoxy-3-methylphenol, 2-methoxy-4-methylphenol, 2-methoxy-5-methylphenol, syringol, syringaldehyde, 2,6-dimethoxy-3-methylphenol, 2,6-dimethoxy-4-methylphenol, 2,6-dimethylphenol, and/or 2,6-dimethoxy-4-(prop-2-enyl)phenol to produce a distillate comprising one or more of the aforementioned molecules. In selected embodiments, the distillate is produced from a natural product and replicates the flavor and/or aroma of the natural product.
Various aspects of this disclosure relate to biphasic compositions comprising one or both of solid-phase carbonate and solid-phase phosphate, which are capable of buffering a liquid phase to stabilize a liquid-phase anion.
Various aspects of the disclosure relate to methods and systems for extracting plant oil from plant material. A system may comprise a microwave emitter, an extraction chamber, and a cooling chamber. Microwave radiation emitted by the microwave emitter may dielectrically heat a microwave absorbing agent, which may heat the plant oil of the plant material. Plant oil of the plant material may be volatized in the extraction chamber and may be directed into the cooling chamber to be condensed.
This patent document describes excipients that allow certain bioactive agents that exist as hydrophobic molecules to be reformulated as anions that display improved hydrophilicity, which can improve the bioavailability and pharmacokinetics of broad classes of pharmaceuticals.
A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/4741 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
Various aspects of this disclosure relate to excipients comprising a solid phase and a liquid phase, wherein the solid phase has a surface-area-to-volume ratio of at least 500 per meter, which improves the bioavailability and pharmacokinetics of various hydrophobic ingredients. Compositions comprising such excipients can be utilized to disperse a hydrophobic ingredient in a beverage, which improves the bioavailability and pharmacokinetics of the dispersed hydrophobic ingredient.
Various aspects of this disclosure relate to (1) methods to perform a ring contraction in the gas phase, (2) compositions obtainable by such methods, and (3) reaction vessels that contain compositions that comprise either a reactant or a product of the ring contraction.
C07C 45/67 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton
10.
COMPOSITIONS FOR LOW-TEMPERATURE DISTILLATION OF HIGH-BOILING-POINT MOLECULES
Various aspects of this disclosure relate to a composition, comprising a gas phase and a condensed phase, wherein the gas phase comprises a molecule; the condensed phase comprises the molecule; the gas phase has a temperature and a pressure; the molecule has a boiling point at the pressure of the gas phase; the boiling point of the molecule is less than the temperature of the gas phase; the molecule has a vapor pressure at the temperature of the gas phase; the vapor pressure of the molecule is less than the pressure of the gas phase; the condensed phase consists of one or both of a solid phase and a liquid phase; the condensed phase is suspended in the gas phase; and the condensed phase has a surface-area-to-volume ratio of at least 500 per meter.
Various aspects of this disclosure relate to the discovery that converting a solid or a liquid into an aerosol allows the distillation of molecules from the aerosol in seconds at temperatures that are significantly less than the boiling points of the molecules. Various aspects of this disclosure relate to the discovery that mute plants can be extracted at both ambient temperatures and temperatures significantly less than the boiling points of the volatile molecules of the mute plants by capturing the volatile molecules in a solvent such as ethanol.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
B01D 3/30 - Fractionating columns with movable parts or in which centrifugal movement is caused
Various aspects of this disclosure relate to a composition, comprising a liquid phase that comprises a plurality of cations, an anion, a molecule, a base, and a solvent, wherein the plurality of cations, the anion, the molecule, and the base are solutes that are dissolved in the solvent; each cation of the plurality of cations is a metal cation or an ammonium cation; the molecule is a cannabinoid; the solvent is not water; the solvent has a solubility in water at 37 degrees Celsius of at least 25 grams per liter; each cation of the plurality of cations has a net charge of 1, 2, or 3; the anion has a net charge of −1; the molecule lacks a net charge; the base has a net charge of −1; the composition has a molar concentration for the anion, the molecule, the base, and each cation of the plurality of cations; the composition has an equivalent concentration for each cation of the plurality of cations, which is equal to the molar concentration of a cation multiplied by the net charge of the same cation; the composition has a combined equivalent concentration of the plurality of cations, which is equal to the sum of the equivalent concentrations of the cations of the plurality of cations; the combined equivalent concentration is no less than the molar concentration of the anion; the combined equivalent concentration is greater than the molar concentration of the base; the molar concentration of the anion is greater than the molar concentration of the molecule; the molar concentration of the solvent is at least 100 times greater than the molar concentration of the base; the liquid phase comprises the solvent at a greater concentration by mass than any other chemical species that is present in the liquid phase; the molecule has an acid dissociation constant in water of at least 50 femtomolar and no greater than 50 nanomolar for conversion of the molecule into the anion; the solvent has an acid dissociation constant in water of at least 50 attomolar for conversion of the solvent into the base; the acid dissociation constant of the molecule is at least 10 times greater than the acid dissociation constant of the solvent; the molecule has an octanol-water partition coefficient at 37 degrees Celsius that is greater than 1; the molecule has a solubility in water, which is the maximum thermodynamically-stable molar concentration of the molecule that can be dissolved in distilled water as a solute that is solvated by water at atmospheric pressure and 21 degrees Celsius; and the molar concentration of the anion is greater than the solubility of the molecule in water. In some embodiments, the composition is effective to inhibit TNF-alpha mediated signaling pathways in a human.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
13.
PRODUCTS AND METHODS RELATED TO THE DISTILLATION OF MOLECULES FROM AEROSOLS
Various aspects of this disclosure relate to the discovery that converting a solid or a liquid into an aerosol allows the distillation of molecules from the aerosol in seconds at temperatures that are significantly less than the boiling points of the molecules. Various aspects of this disclosure relate to the discovery that mute plants can be extracted at both ambient temperatures and temperatures significantly less than the boiling points of the volatile molecules of the mute plants by capturing the volatile molecules in a solvent such as ethanol.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
14.
PRODUCTS AND METHODS RELATED TO THE DISTILLATION OF MOLECULES FROM AEROSOLS
Various aspects of this disclosure relate to the discovery that converting a solid or a liquid into an aerosol allows the distillation of molecules from the aerosol in seconds at temperatures that are significantly less than the boiling points of the molecules. Various aspects of this disclosure relate to the discovery that mute plants can be extracted at both ambient temperatures and temperatures significantly less than the boiling points of the volatile molecules of the mute plants by capturing the volatile molecules in a solvent such as ethanol.
Various aspects of this disclosure relate to a composition, comprising a gas phase and a condensed phase, wherein the gas phase comprises a molecule; the condensed phase comprises the molecule; the gas phase has a temperature and a pressure; the molecule has a boiling point at the pressure of the gas phase; the boiling point of the molecule is less than the temperature of the gas phase; the molecule has a vapor pressure at the temperature of the gas phase; the vapor pressure of the molecule is less than the pressure of the gas phase; the condensed phase consists of one or both of a solid phase and a liquid phase; the condensed phase is suspended in the gas phase; and the condensed phase has a surface-area-to-volume ratio of at least 500 per meter.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
Various aspects of this disclosure relate to a composition, comprising a gas phase and a condensed phase, wherein the gas phase comprises a molecule; the condensed phase comprises the molecule; the gas phase has a temperature and a pressure; the molecule has a boiling point at the pressure of the gas phase; the boiling point of the molecule is less than the temperature of the gas phase; the molecule has a vapor pressure at the temperature of the gas phase; the vapor pressure of the molecule is less than the pressure of the gas phase; the condensed phase consists of one or both of a solid phase and a liquid phase; the condensed phase is suspended in the gas phase; and the condensed phase has a surface-area-to-volume ratio of at least 500 per meter.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C07D 311/78 - Ring systems having three or more relevant rings
C07C 29/80 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
18.
COMPOSITIONS, CONTAINERS, AND METHODS RELATED TO FLAVYLIUM EXCIPIENTS
Various aspects of this disclosure relate to a composition, comprising a liquid phase that consists of chemical species that comprise tetrahydrocannabinol, one or more flavyliums, and a solvent, wherein each chemical species of the liquid phase has a concentration in the liquid phase; the tetrahydrocannabinol is dissolved in the liquid phase at a concentration of at least 0.1 percent and no greater than 8 percent by mass; each flavylium of the one or more flavyliums is a substituted 2-phenylchromenylium that consists of carbon, hydrogen, and oxygen atoms; the solvent is miscible with water; and the liquid phase comprises the solvent at a greater concentration by mass than any other chemical species of the liquid phase.
This disclosure relates to the discovery that improved flavors and fragrances can be manufactured during a rapid heating and cooling process that performs simultaneous thermal decomposition of a reactant and distillation of the thermal decomposition product. Various aspects of this disclosure relate to the discovery that the rate of thermal decomposition and distillation can be varied to produce a range of flavor and fragrance molecules in formats compatible with direct addition to consumer products.
C07D 307/68 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C08H 8/00 - Macromolecular compounds derived from lignocellulosic materials
C07D 307/36 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
21.
Method and apparatus for extracting botanical oils
Various aspects of this patent document relate to a method to extract an oil from a plant material using an apparatus by first exposing the plant material to a heated gas stream at a temperature sufficient to volatilize the oil from the plant material, and then rapidly cooling the gas stream to liquefy the oil.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
C11B 9/02 - Recovery or refining of essential oils from raw materials
This patent document discloses compositions comprising novel combinations of cannabinoids, terpenes, and thermal degradation products that can be obtained, for example, by the vapor-phase decarboxylation of a cannabis extract.
A61K 31/336 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/047 - Hydroxy compounds, e.g. alcoholsSalts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
23.
BIPHASIC COMPOSITIONS COMPRISING ONE OR BOTH OF CARBONATE AND PHOSPHATE
Various aspects of this disclosure relate to biphasic compositions comprising one or both of solid-phase carbonate and solid-phase phosphate, which are capable of buffering a liquid phase to stabilize a liquid-phase anion.
Various aspects of this disclosure relate to biphasic compositions comprising one or both of solid-phase carbonate and solid-phase phosphate, which are capable of buffering a liquid phase to stabilize a liquid-phase anion.
Various aspects of this disclosure relate to excipients comprising a solid phase and a liquid phase, wherein the solid phase has a surface-area-to-volume ratio of at least 500 per meter, which improves the bioavailability and pharmacokinetics of various hydrophobic ingredients. Compositions comprising such excipients can be utilized to disperse a hydrophobic ingredient in a beverage, which improves the bioavailability and pharmacokinetics of the dispersed hydrophobic ingredient.
Various aspects of this disclosure relate to a composition, comprising a liquid phase that consists of chemical species that comprise a solvent and solutes, wherein: each solute of the solutes is dissolved in the solvent of the liquid phase; each chemical species of the liquid phase has a concentration by mass in the liquid phase; the concentration by mass of the solvent in the liquid phase is greater than the concentration by mass of each solute of the liquid phase; the solvent is glycerol; the solutes comprise a cannabinoid; the liquid phase has a pressure and temperature; the cannabinoid has a solubility in glycerol at the pressure and temperature; the concentration by mass of the cannabinoid in the liquid phase is greater than the solubility of the cannabinoid in glycerol at the pressure and temperature; the composition is formulated for oral consumption; and the composition comprises at least 0.1 and no greater than 6 food calories per gram of the composition.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Various aspects of this disclosure relate to (1) methods to perform a ring contraction in the gas phase, (2) compositions obtainable by such methods, and (3) reaction vessels that contain compositions that comprise either a reactant or a product of the ring contraction.
C07C 5/29 - Rearrangement of carbon atoms in the hydrocarbon skeleton changing the number of carbon atoms in a ring while maintaining the number of rings
C07C 13/23 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring with a cyclohexadiene ring
C07C 13/15 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a five-membered ring with a cyclopentadiene ring
C07C 5/22 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by isomerisation
30.
COMPOSITIONS FOR LOW-TEMPERATURE DISTILLATION OF HIGH-BOILING-POINT MOLECULES
Various aspects of this disclosure relate to a composition, comprising a gas phase and a condensed phase, wherein the gas phase comprises a molecule; the condensed phase comprises the molecule; the gas phase has a temperature and a pressure; the molecule has a boiling point at the pressure of the gas phase; the boiling point of the molecule is less than the temperature of the gas phase; the molecule has a vapor pressure at the temperature of the gas phase; the vapor pressure of the molecule is less than the pressure of the gas phase; the condensed phase consists of one or both of a solid phase and a liquid phase; the condensed phase is suspended in the gas phase; and the condensed phase has a surface-area-to-volume ratio of at least 500 per meter.
Various aspects of this disclosure relate to the discovery that converting a solid or a liquid into an aerosol allows the distillation of molecules from the aerosol in seconds at temperatures that are significantly less than the boiling points of the molecules. Various aspects of this disclosure relate to the discovery that mute plants can be extracted at both ambient temperatures and temperatures significantly less than the boiling points of the volatile molecules of the mute plants by capturing the volatile molecules in a solvent such as ethanol.
Various aspects of this disclosure relate to compositions comprising (i) one or more decarboxylated cannabinoids and (ii) either (a) cellulose I, (b) nucleic acids that comprise one or more nucleotide sequences that encode a geranyl-pyrophosphate-olivetolic acid geranyltransferase, (c) protein that comprises one or more amino acid sequences that encode a geranyl-pyrophosphate-olivetolic acid geranyltransferase, (d) two of a, b, and c, or (e) each of a, b, and c.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
Various aspects of this patent document relate to bioactive compositions comprising anions that are converted into hydrophobic bioactive molecules either ex vivo prior to administration to a subject or in situ subsequent to administration to a subject. Such compositions display improved bioavailability and pharmacokinetics relative to compositions that comprise the hydrophobic bioactive molecules instead of the anions.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
This patent document describes excipients that allow certain bioactive agents that exist as hydrophobic molecules to be reformulated as anions that display improved hydrophilicity, which can improve the bioavailability and pharmacokinetics of broad classes of pharmaceuticals.
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
35.
CANNABIGEROL AND CANNABIGEROL DERIVATIVES FOR USE TO TREAT HEALTH CONDITIONS IN HUMANS
Various aspects of this patent document relate to the findings that cannabigerol ("CBG") and CBG derivatives are tumor necrosis factor alpha ("TNF-alpha") signaling pathway inhibitors that are effective to treat pain, inflammation, and obesity in pre-clinical models and that CBG and CBG derivatives also display efficacy against a wide range of health conditions in humans including anxiety, insomnia, cramping, restless-legs syndrome, Irritable Bowel Syndrome, Crohn's disease, plaque psoriasis, and peripheral neuropathy.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 43/00 - Drugs for specific purposes, not provided for in groups
36.
COMPOSITIONS AND METHODS RELATED TO CANNABINOID ANIONS
Various aspects of the disclosure relate to compositions comprising a cannabinoid anion, wherein the cannabinoid anion is the conjugate base of a cannabinoid molecule, and the cannabinoid molecule has an acid dissociation constant in water of at least 50 femtomolar and no greater than 50 nanomolar for conversion of the cannabinoid molecule into the cannabinoid anion. In some embodiments, a composition is effective to inhibit TNF-alpha-mediated signaling pathways in a human.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
This disclosure relates to a composition, comprising a liquid phase that comprises a plurality of cations, an anion, a molecule, a base, and a solvent, wherein the plurality of cations, the anion, the molecule, and the base are solutes that are dissolved in the solvent. Each cation of the plurality of cations is a metal cation or an ammonium cation, the molecule is a cannabinoid, the solvent is not water. The molecule has a solubility in water, which is the maximum thermodynamically-stable molar concentration of the molecule that can be dissolved in distilled water as a solute that is solvated by water at atmospheric pressure and (21) degrees Celsius, and the molar concentration of the anion is greater than the solubility of the molecule in water. In some embodiments, the composition is effective to inhibit TNF-alpha mediated signaling pathways in a human.
A61K 45/08 - Mixtures of an active ingredient and an auxiliary substance neither being chemically characterised, e.g. antihistaminicum and surface active substance
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
38.
CONTAINERS, COMPOSITIONS, AND METHODS RELATED TO CANNABINOID ANIONS
Various aspects of this patent document relate cannabinoid anions including methods to produce cannabinoid anions, compositions comprising cannabinoid anions, containers that contain compositions comprising cannabinoid anions, and methods to consume cannabinoid anions.
Various aspects of this patent document relate to beverage concentrates that comprise active ingredients, containers comprising beverage concentrates, and methods to prepare beverage formulations from beverage concentrates.
Various aspects of this patent document relate to compositions and methods to purify cannabinoids from impurities by crystallization without the use of alkanes.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
B01D 15/02 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor with moving adsorbents
B01D 15/04 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor with ion-exchange materials as adsorbents
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
C07C 29/84 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation by extractive distillation
C07C 7/14 - Purification, separation or stabilisation of hydrocarbonsUse of additives by crystallisationPurification or separation of the crystals
42.
Compositions with novel cannabinoid and terpene profiles
This patent document discloses combinations of cannabinoids, terpenes, terpene oxidation products, and stereoisomers of cannabinoids and terpene oxidation products.
Various aspects of this patent document relate to beverage concentrates that comprise active ingredients, containers comprising beverage concentrates, and methods to prepare beverage formulations from beverage concentrates.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 9/00 - Medicinal preparations characterised by special physical form
A23L 2/395 - Dry compositions in a particular shape or form
Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.
C07D 311/78 - Ring systems having three or more relevant rings
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
C07C 29/80 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
45.
COMPOSITIONS AND METHODS RELATED TO ISOMERS OF CURCUMIN
Various aspects of this disclosure relate to compositions comprising anionic forms of structural isomers of curcumin that can be prepared from curcumin using acid-base chemistry, and other aspects relate to methods to administer such compositions.
C07C 49/647 - Unsaturated compounds containing a keto group being part of a ring having unsaturation outside the ring
C07C 49/713 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
C07C 49/248 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 49/235 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the aromatic rings
C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
Various aspects of the disclosure relate to methods and systems for extracting plant oil from plant material. A system may comprise a microwave emitter, an extraction chamber, and a cooling chamber. Microwave radiation emitted by the microwave emitter may dielectrically heat a microwave absorbing agent, which may heat the plant oil of the plant material. Plant oil of the plant material may be volatized in the extraction chamber and may be directed into the cooling chamber to be condensed.
Various aspects of this patent document relate to liquid compositions comprising cannabidiol, which have either freezing points or glass-liquid transition temperatures less than the melting point of pure cannabidiol.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A24B 15/167 - Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
Various aspects of this patent document relate to bioactive compositions comprising anions that are converted into hydrophobic bioactive molecules either ex vivo prior to administration to a subject or in situ subsequent to administration to a subject. Such compositions display improved bioavailability and pharmacokinetics relative to compositions that comprise the hydrophobic bioactive molecules instead of the anions.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
A61K 31/566 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol having an oxo group in position 17, e.g. oestrone
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Various aspects of the disclosure relate to compositions comprising a liquid phase that comprises a cannabinoid anion, wherein the cannabinoid anion is the conjugate base of a cannabinoid molecule, and the cannabinoid molecule has an acid dissociation constant in water of at least 50 femtomolar and no greater than 50 nanomolar for conversion of the cannabinoid molecule into the cannabinoid anion.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
This disclosure generally relates to gas-phase methods to simultaneously purify and decarboxylate cannabinoids in about two seconds, which are about 100-10,000 times more efficient than conventional purification and decarboxylation strategies. The methods also recover thermolabile cannabinoids such as cannabigerol at significantly higher yields than conventional methods.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
This disclosure generally relates to gas-phase methods to simultaneously purify and decarboxylate cannabinoids in about two seconds, which are about 100-10,000 times more efficient than conventional purification and decarboxylation strategies. The methods also recover thermolabile cannabinoids such as cannabigerol at significantly higher yields than conventional methods.
Various aspects of this patent document relate to bioactive compositions comprising anions that are converted into hydrophobic bioactive molecules either ex vivo prior to administration to a subject or in situ subsequent to administration to a subject. Such compositions display improved bioavailability and pharmacokinetics relative to compositions that comprise the hydrophobic bioactive molecules instead of the anions.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61P 5/02 - Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
This patent document describes excipients that allow certain bioactive agents that exist as hydrophobic molecules to be reformulated as anions that display improved hydrophilicity, which can improve the bioavailability and pharmacokinetics of broad classes of pharmaceuticals.
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 47/50 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
57.
COMPOSITIONS COMPRISING NOVEL CANNABINOID AND TERPENE PROFILES
This patent document discloses compositions comprising novel combinations of cannabinoids, terpenes, and thermal degradation products that can be obtained, for example, by the vapor-phase decarboxylation of a cannabis extract.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 47/06 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
Various aspects of this patent document relate to a method to extract an oil from a plant material using an apparatus by first exposing the plant material to a heated gas stream at a temperature sufficient to volatilize the oil from the plant material, and then rapidly cooling the gas stream to liquefy the oil.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 9/02 - Recovery or refining of essential oils from raw materials
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
Various aspects of this patent document relate to pharmaceutical compositions comprising cannabinoid anions for use as medicaments and compositions comprising cannabinoid anions for use to manufacture such medicaments.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 39/00 - General protective or antinoxious agents
60.
METHODS OF PREVENTING AND TREATING HEALTH CONDITIONS USING CANNABINOID ANIONS
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Various aspects of this patent document relate to pharmaceutical compositions comprising cannabinoid anions for use as medicaments and compositions comprising cannabinoid anions for use to manufacture such medicaments.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61P 39/00 - General protective or antinoxious agents
62.
METHODS TO SEPARATE CANNABINOIDS FROM IMPURITIES BY CRYSTALLIZATION
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
C07C 7/14 - Purification, separation or stabilisation of hydrocarbonsUse of additives by crystallisationPurification or separation of the crystals
A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Various aspects of this disclosure relate to compositions comprising (i) one or more decarboxylated cannabinoids and (ii) either (a) cellulose I, (b) nucleic acids that comprise one or more nucleotide sequences that encode a geranyl-pyrophosphate-olivetolic acid geranyltransferase, (c) protein that comprises one or more amino acid sequences that encode a geranyl-pyrophosphate-olivetolic acid geranyltransferase, (d) two of a, b, and c, or (e) each of a, b, and c.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Various aspects of this patent document relate to compositions that comprise an anion that is the conjugate base of a hydrophobic molecule that has a pKa, for example, of at least 7 and no greater than 12. These compositions display improved properties when formulated to interact with an organism because the anions carry negative charges that allows them to both dissolve in water-miscible liquids and maximize their surface area. Interaction with an organism results in at least partial conversion of the anion into the hydrophobic molecule after which the hydrophobic molecule partitions out of a water-miscible liquid and into the organism.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Various aspects of this patent document relate cannabinoid anions including methods to produce cannabinoid anions, compositions comprising cannabinoid anions, containers that contain compositions comprising cannabinoid anions, and methods to consume cannabinoid anions.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
70.
Compositions comprising non-crystalline forms of cannabidiol
Various aspects of this patent document relate to liquid compositions comprising cannabidiol, which have either freezing points or glass-liquid transition temperatures less than the melting point of pure cannabidiol.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A24F 47/00 - Smokers’ requisites not otherwise provided for
Various aspects of this patent document relate to (i) compositions comprising cannabidiol, which have either a freezing point or a glass-liquid transition temperature of less than the melting point of pure cannabidiol, (ii) containers that contain such compositions, and (iii) methods to manufacture cannabidiol products.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61J 3/00 - Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
72.
COMPOSITIONS COMPRISING NON-CRYSTALLINE FORMS OF CANNABIDIOL
Various aspects of this patent document relate to (i) compositions comprising cannabidiol, which have either a freezing point or a glass-liquid transition temperature of less than the melting point of pure cannabidiol, (ii) containers that contain such compositions, and (iii) methods to manufacture cannabidiol products.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Various aspects of the disclosure relate to compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol.
C07D 311/78 - Ring systems having three or more relevant rings
C07C 29/80 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
75.
METHOD AND APPARATUS FOR EXTRACTING BOTANICAL OILS
Various aspects of the disclosure relate to methods and systems for extracting oil from plant material. A system may comprise a gas moving device, an extraction chamber, and a condensation surface. Oil of the plant material may be volatized in the extraction chamber and then propelled by the gas moving device to the condensation surface to be collected. In various embodiments, the systems and methods allow the extraction of oil from plant material with little or no solvent.
B01D 45/12 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
Various aspects of this patent application relate to methods to separate a cannabinoid molecule from other molecules of a decarboxylated cannabinoid extract.
C07C 39/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic part, with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
C07C 37/50 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
C07C 37/72 - SeparationPurificationStabilisationUse of additives by physical treatment by liquid-liquid treatment
C07C 37/84 - SeparationPurificationStabilisationUse of additives by physical treatment by crystallisation
This patent document discloses combinations of cannabinoids, terpenes, terpene oxidation products, and stereoisomers of cannabinoids and terpene oxidation products.
A61K 31/00 - Medicinal preparations containing organic active ingredients
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
80.
Methods of administering anionic cannabinoid molecules dissolved in water
Various aspects of this patent application relate to methods to separate a cannabinoid molecule from other molecules of a decarboxylated cannabinoid extract.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
An apparatus for extracting an oil from plant material includes an extraction chamber for plant material. The plant material is exposed to a heated gas stream with a temperature sufficient to volatilize on oil from the plant material. The gas stream is rapidly cooled to liquefy the oil into entrained droplets. The oil is collected with a collection solvent.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 9/02 - Recovery or refining of essential oils from raw materials
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
Compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
Various aspects of the disclosure relate to compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol.
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
C07C 39/19 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
85.
Methods to separate cannabidiol and tetrahydrocannabinol
Various aspects of this patent document relate to methods to separate cannabidiol and tetrahydrocannabinol by adjusting their solubility in alcohol and water solutions.
Various aspects of the disclosure relate to methods and systems for extracting plant oil from plant material. A system may comprise a microwave emitter, an extraction chamber, and a cooling chamber. Microwave radiation emitted by the microwave emitter may dielectrically heat a microwave absorbing agent, which may heat the plant oil of the plant material. Plant oil of the plant material may be volatized in the extraction chamber and may be directed into the cooling chamber to be condensed.
Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.
C07C 37/50 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.
C07D 311/78 - Ring systems having three or more relevant rings
C07C 29/80 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.
C07C 37/50 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
Various aspects of this disclosure relate to methods to lower the activation energy of the cannabinoid decarboxylation reaction by performing the decarboxylation reaction in the gas phase.
C07C 37/48 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by exchange of hydrocarbon groups which may be substituted, from other compounds, e.g. transalkylation
C07C 35/21 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
92.
Methods of producing anionic cannabinoid molecules dissolved in water
Various aspects of the disclosure relate to methods and systems for extracting oil from plant material. A system may comprise a gas moving device, an extraction chamber, and a condensation surface. Oil of the plant material may be volatized in the extraction chamber and then propelled by the gas moving device to the condensation surface to be collected. In various embodiments, the systems and methods allow the extraction of oil from plant material with little or no solvent.
B01D 45/12 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
B01D 45/16 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces generated by the winding course of the gas stream
94.
Method and apparatus for extracting botanical oils
An apparatus for extracting an oil from plant material includes an extraction chamber for plant material. The plant material is exposed to a heated gas stream with a temperature sufficient to volatilize on oil from the plant material. The gas stream is rapidly cooled to liquefy the oil into entrained droplets. The oil is collected with a collection solvent.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
C11B 9/02 - Recovery or refining of essential oils from raw materials
Various aspects of the disclosure relate to methods and systems for extracting plant oil from plant material. A system may comprise a microwave emitter, an extraction chamber, and a cooling chamber. Microwave radiation emitted by the microwave emitter may dielectrically heat a microwave absorbing agent, which may heat the plant oil of the plant material. Plant oil of the plant material may be volatized in the extraction chamber and may be directed into the cooling chamber to be condensed.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
Various aspects of the disclosure relate to methods and systems for extracting oil from plant material. A system may comprise a gas moving device, an extraction chamber, and a condensation surface. Oil of the plant material may be volatized in the extraction chamber and then propelled by the gas moving device to the condensation surface to be collected. In various embodiments, the systems and methods allow the extraction of oil from plant material with little or no solvent.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
B01D 45/12 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces
B01D 45/14 - Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces generated by rotating vanes, discs, drums or brushes
B01D 47/05 - Separating dispersed particles from gases, air or vapours by liquid as separating agent by condensation of the separating agent
97.
IMPROVED METHOD AND APPARATUS FOR EXTRACTING BOTANICAL OILS
A system for extracting oil from plant material includes a gas moving device propelling a gas stream, the gas stream being a stream of air or gas with or without entrained vapor, solids or droplets of liquid therein. The gas stream is directed through an extraction chamber, which is operable to volatize at least a portion of an oil from a plant material such that the volatilized oil is disposed in the gas stream as an extracted oil. A collection chamber is in communication with the extraction chamber such that the gas stream flows through the collection chamber. The collection chamber has collection solvent operable to collect at least a portion of the extracted oil from the gas stream. A liquid collector is in fluid communication with the collection chamber for collecting at least a portion of the collection solvent and extracted oil.
A system for extracting oil from plant material includes a gas moving device propelling a gas stream, the gas stream being a stream of air or gas with or without entrained vapor, solids or droplets of liquid therein. The gas stream is directed through an extraction chamber, which is operable to volatize at least a portion of an oil from a plant material such that the volatilized oil is disposed in the gas stream as an extracted oil. A collection chamber is in communication with the extraction chamber such that the gas stream flows through the collection chamber. The collection chamber has collection solvent operable to collect at least a portion of the extracted oil from the gas stream. A liquid collector is in fluid communication with the collection chamber for collecting at least a portion of the collection solvent and extracted oil.
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
An apparatus for extracting an oil from plant material includes an extraction chamber for plant material. The plant material is exposed to a heated gas stream with a temperature sufficient to volatilize on oil from the plant material. The gas stream is rapidly cooled to liquefy the oil into entrained droplets. The oil is collected with a collection solvent.
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
An apparatus for extracting an oil from plant material includes an extraction chamber for plant material. The plant material is exposed to a heated gas stream with a temperature sufficient to volatilize on oil from the plant material. The gas stream is rapidly cooled to liquefy the oil into entrained droplets. The oil is collected with a collection solvent.
B01D 3/34 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping with one or more auxiliary substances
C11B 1/10 - Production of fats or fatty oils from raw materials by extracting
C11B 1/12 - Production of fats or fatty oils from raw materials by melting out
C11B 3/12 - Refining fats or fatty oils by distillation
patents
