Abstract

A reaction-path search system calculates a reaction path in a structure formed of multiple atoms as a change in a structure represented by a positional relationship of the multiple atoms. The reaction-path search system including: a structural change calculation unit which calculates a change in the structure in which a result of a function FAFIR(Q) is at the minimum; a differential coefficient calculation unit which calculates at least one of a second differential coefficient b or a third differential coefficient a of E(Q) at the positions of the multiple atoms; and an equilibrium state change calculation unit which causes the structural change calculation unit to calculate the change in the structure in transition from the first equilibrium state to the second equilibrium state, prior to the other fragment pairs with lower priority than the fragment pair with higher priority based on the magnitude of a and b.

IPC Classes  ?

• G16C 20/40 - Searching chemical structures or physicochemical data
• G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes

Abstract

A reservoir device receives input of time series sensor data measured in a predetermined process and outputs a reservoir feature value based on a result of processing using an input weight multiplier and a connection weight multiplier, in which the input weight multiplier weights the input sensor data, using a value determined by a periodic function as an input weight, and the connection weight multiplier performs weighted addition of data indicating states of nodes, using a value determined by a periodic function as a connection weight between two nodes among the nodes.

IPC Classes  ?

• G06F 30/28 - Design optimisation, verification or simulation using fluid dynamics, e.g. using Navier-Stokes equations or computational fluid dynamics [CFD]

Abstract

An antitumor agent according to the present disclosure contains, as an active ingredient, at least one component selected from the group consisting of ribozyme nucleic acids, antisense nucleic acids, RNAi-inducing nucleic acids, dominant negative variants, and aptamers, and vectors that express the same.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/15 - Medicinal preparations
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Provided is a method for efficiently producing heterologous T cell receptor or chimeric antigen receptor gene-introduced leukocytes.　The present invention relates to: a method for producing modified leukocytes, such as T cells to which heterologous a T-cell receptor or a chimeric antigen receptor gene has been introduced, by adding a ferroptosis inhibitor during the production step; and modified leukocytes produced by the method according to the present invention.

IPC Classes  ?

• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 1/04 - Preserving or maintaining viable microorganisms
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/13 - Immunoglobulins
• C12N 15/62 - DNA sequences coding for fusion proteins
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

Abstract

The present invention provides a neurite outgrowth promoter for promoting neurite growth on nerve cells of a postnatal mammalian individual for use in a condition in which an effective amount of a glial cell-derived neurotrophic factor (GDNF) is not present, the neurite outgrowth promoter containing at least one protein selected from the group consisting of: GDNF family receptor α1 (GFRα1): GFRα1 mutants having an amino acid sequence that has at least 90% sequence identity with the amino acid sequence of GFRα1, the GFRα1 mutants having neurite outgrowth activity; fusion proteins that have neurite outgrowth activity and that are obtained by fusing GFRα1 or a GFRα1 mutant with another peptide; and chemically modified proteins that have neurite outgrowth activity and that are obtained by chemically modifying one or a plurality of amino acid residues in GFRα1, a GFRα1 mutant, or a fusion protein. The present invention also provides a pharmaceutical composition for inducing nerve regeneration.

IPC Classes  ?

• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators

Abstract

The objective of the present invention is to alleviate a work load at the time of start-up in a prediction system equipped with a reservoir. This prediction system includes: a calibration-verified AI device in which a plurality of physical reservoirs for processing time-series signals are connected to each other; and a trained prediction device that reads outputs from the plurality of physical reservoirs included in the calibration-verified AI device while adding reading weights and outputs a predicted value. The calibration-verified AI device has the plurality of physical reservoirs verified to be calibrated so that the physical properties of the physical reservoirs are the same by adding M-series noise to the time-series signals. The trained prediction device has read weights duplicated from another trained prediction device that reads outputs from a plurality of other physical reservoirs having the same physical properties as the plurality of physical reservoirs while adding reading weights and outputs a predicted value, and that has read weights updated by training.

IPC Classes  ?

• G06N 3/044 - Recurrent networks, e.g. Hopfield networks
• G06N 3/065 - Analogue means

Abstract

The purpose of the present invention is to provide an annular device that, in comparison to convention annular devices, suppresses the effects of frictional force which occurs between the annular device and the palpebral conjunctiva during blinking, and that has excellent stability on the eyeball when worn. This purpose is achieved by, for example, an annular device that is to be worn on the surface of the sclera and that comprises: an opening which exposes the cornea; and main body which has a non-slab-off region and a slab-off region formed such that the maximum thickness thereof gradually decreases from a right end part side to an upper end part side and to a lower end part side, and from a left end part side to the upper end part side and to the lower end part side.

IPC Classes  ?

• A61F 9/007 - Methods or devices for eye surgery

Abstract

Provided is a particle beam treatment system capable of more effectively radiating a particle beam. This particle beam treatment system comprises: a radiation device 25 for radiating particle beams B1, B2; and a control device 40 for controlling the radiation device. The control device causes the plurality of particle beams B1, B2, which are for different purposes but are of the same type, to be radiated from the radiation device to an irradiation subject 31 at different timings.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G21K 5/04 - Irradiation devices with beam-forming means

Abstract

A metal porous body includes a framework having a three-dimensional mesh structure, wherein the framework includes a plurality of columnar supporting portions and a node portion that connects the plurality of columnar supporting portions, the framework is provided with a plurality of opening holes opened in a surface of the framework, and the framework contains at least one selected from a group consisting of nickel, cobalt, iron, tin, copper, and chromium.

IPC Classes  ?

• C25B 11/031 - Porous electrodes
• C25B 11/046 - Alloys

Abstract

The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity. The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity. The present invention provides a pharmaceutical composition comprising a compound exhibiting coronavirus proliferation inhibitory activity. A pharmaceutical composition comprising a compound represented by the formula: wherein Y is N; R1 is substituted or unsubstituted aromatic heterocyclyl; R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl; R3 is substituted or unsubstituted aromatic heterocyclyl; —X— is —NH—; m is 0 or 1; R5a is a hydrogen atom; R5b is a hydrogen atom; n is 1; R4a is a hydrogen atom; and R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof.

IPC Classes  ?

• A61K 31/53 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The purpose of the invention described herein is to provide a compound having a novel chemical structure that is usable for lipid nanoparticles. Disclosed are a compound represented by formula (I) (in the formula, R1and R2are each independently a C10-24 chain hydrocarbon group, R3 is a C1-22 chain hydrocarbon group) and lipid nanoparticles containing the compound.

IPC Classes  ?

• C07F 9/09 - Esters of phosphoric acids
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy

Abstract

The present invention provides: a neutral lipid capable of suppressing the phase transition of endosomal membranes caused by phosphatidylcholine from being inhibited; and a lipid nanoparticle containing said neutral lipid. The present invention pertains to an ionic neutral lipid comprising a compound represented by general formula (I). [In formula (I), R1 is a C1-22 hydrocarbon group; three R1's in one molecule may be the same group or different groups; a1 and a2 are each independently an integer of 0 to 4; b1 and b2 are 0 or 1, satisfying b1+b2=1; R2 and R3 are each independently a hydrogen atom or a C1-3 alkyl group; and R4 is an anionic group.]

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• C07C 237/08 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms

Abstract

An optical filter includes a first multiplexer having a first input end, a second input end, a first output end, and a second output end, a first waveguide optically coupled to the first input end, a second waveguide optically coupled to the second input end, a third waveguide optically coupled to the first output end, a fourth waveguide optically coupled to the second output end, and a ring resonator optically coupled to the third waveguide and the fourth waveguide.

IPC Classes  ?

• H01S 3/083 - Ring lasers
• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

33 (0 ≤ x ≤ 0.5) or PLTZ.

IPC Classes  ?

• H10N 30/853 - Ceramic compositions
• H10N 30/076 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by vapour phase deposition
• H10N 30/88 - MountsSupportsEnclosuresCasings

Abstract

Provided is a compound which is synthesized using an amino acid that can be easily procured in the marketplace and used industrially, has activity for inhibiting adhesion of fouling present in sea water, and has low toxicity. The present invention relates to: a dipeptide containing a proline residue which is represented by formula (1), or a tripeptide containing a proline residue and a phenylalanine residue [in the formula, R13-103-10 hydrocarbon group, R2and R31-81-8 hydrocarbon group or the like, and R41-61-6 hydrocarbon group or the like]; and a composition for inhibiting adhesion of marine fouling, which contains this compound.

IPC Classes  ?

• C07K 5/097 - Tripeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp, e.g. thyroliberin, melanostatin
• A01N 43/36 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
• A01P 7/00 - Arthropodicides
• A01P 9/00 - Molluscicides
• C07K 5/078 - Dipeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp

Abstract

122 includes a dichloroacetyl group.) These copolymers or polymeric micelles which are formed from these copolymers in an aqueous medium have a tumor-specific radiation enhancement effect and enhance the therapeutic effect of radiation therapy on tumors. Consequently, the present invention provides a medical use of these copolymers or polymeric micelles for exerting such an effect.

IPC Classes  ?

• C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
• A61K 9/10 - DispersionsEmulsions
• A61K 9/51 - Nanocapsules
• A61K 31/765 - Polymers containing oxygen
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

outoutoutoutoutvfnoisefgfg of the floating gate transistor FG in accordance with the probability p.

IPC Classes  ?

• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• G06F 7/58 - Random or pseudo-random number generators
• G06G 7/60 - Analogue computers for specific processes, systems, or devices, e.g. simulators for living beings, e.g. their nervous systems
• G11C 16/04 - Erasable programmable read-only memories electrically programmable using variable threshold transistors, e.g. FAMOS

Abstract

The present disclosure is directed to a plasma measurement device comprising: a laser light source configured to apply laser light to plasma; and a spectrum measurement unit configured to receive scattered light from the plasma and measure a wavelength spectrum of the scattered light; and an arithmetic unit configured to calculate an electron temperature and an electron density of the plasma, based on the measured wavelength spectrum, wherein the spectrum measurement unit includes a spectroscope having an incidence slit, the incidence slit including: two blades movable in X-direction in an XY-plane perpendicular to a traveling direction of the scattered light; and at least one blade movable in Y-direction perpendicular to X-direction, edges of at least three of the blades forming a slit shape, thereby relaxing the structural constraints for plasma measurement and performing measurement with higher accuracy.

IPC Classes  ?

• G01J 3/443 - Emission spectrometry
• G01J 3/44 - Raman spectrometryScattering spectrometry

Abstract

The present invention pertains to a dehydrogenation catalyst for producing propylene by a dehydrogenation reaction of propane, said catalyst comprising MFI type zeolite, elemental platinum, and elemental M, wherein: the molar ratio (Si/Al) of silicon to elemental aluminum of the MFI type zeolite is 50 or more; the elemental M is at least one element selected from the group consisting of elemental germanium, elemental copper, elemental indium, elemental iron, elemental ruthenium, and elemental rhenium; and the elemental platinum and the elemental M are located in a channel of the MFI type zeolite.

IPC Classes  ?

• B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
• B01J 37/08 - Heat treatment
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam
• B01J 37/18 - Reducing with gases containing free hydrogen
• C07B 61/00 - Other general methods
• C07C 5/333 - Catalytic processes
• C07C 11/06 - Propene

Abstract

This collagen yarn contains collagen nanofibrils, and has a diameter of 10-50 μm and a total length of 2 × 105times or more greater than the diameter, wherein the collagen nanofibrils exhibit high alignment properties along the longitudinal direction of the collagen yarn, the high alignment properties are indicated by a fact that the refractive index difference determined by a birefringence measurement performed on a hydrated collagen yarn is 4.3 × 10-4 or more, and the hydrated collagen yarn is obtained by immersing the collagen yarn in a neutral phosphate buffer solution.

IPC Classes  ?

• D01F 4/00 - Monocomponent artificial filaments or the like of proteinsManufacture thereof
• A61L 27/24 - Collagen
• D01D 5/06 - Wet spinning methods

Abstract

A method of manufacturing an optical filter is a method of manufacturing an optical filter including two or more waveguides having four or more sections in which a number of modes of light propagating through the four or more sections is two or more. The method includes designing lengths of the four or more sections, and forming the two or more waveguides based on the lengths of the four or more sections. The designing includes designing the lengths of the four or more sections based on differentiation of propagation constants of the sections with respect to a temperature and widths of the sections.

IPC Classes  ?

• G02B 5/28 - Interference filters
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Provided are a pressure sensor and the like that are capable of accurately detecting, as a surface, a pressure applied to an object from the outside.　The present invention is provided with: a plurality of sensor pixels PX that are arranged in a surface formation, the sensor pixels PX being each equipped with a membranous pressure-sensitive film 2 having a resistance value that varies by the front surface of the pressure-sensitive film 2 being pressed, and a first electrode layer 4 and a second electrode layer 6 laminated only on the back surface of the pressure-sensitive film 2; and a drive circuit that drives each of the sensor pixels PX, the drive circuit detecting, according to variations in the resistance values caused by pressing the plurality of sensor pixels PX, the pressure of the pressing for each of the sensor pixels PX.

IPC Classes  ?

• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes

Abstract

A method for producing a cyclic peptide, comprising using a penicillin-binding protein-type thioesterase (PBP-type TE) or a tyrocidine synthase TycC thioesterase domain (TycC-TE) as a catalyst, wherein a diol as a leaving group is attached to a carboxyl group of a C-terminal residue of a substrate; and a method for producing a peptide serving as the substrate using a solid phase carrying a diol.

IPC Classes  ?

• C07K 7/50 - Cyclic peptides containing at least one abnormal peptide link
• C12N 9/16 - Hydrolases (3.) acting on ester bonds (3.1)

Abstract

The present invention enables easy acquisition of an excellent electrical contact while using electrodes made of a metal other than thallium.　A radiation detector 1 is provided with: a crystal 2 containing thallium bromide as the main component; and electrodes 3 and 4 which are in contact with the crystal 2 so as to sandwich the crystal 2 therebetween in an X direction and which are made of a metal other than thallium. Portions of the crystal 2 in contact with the electrodes 3 and 4 are doped with at least one of strontium, lead, thallium, and bromine.

IPC Classes  ?

• G01T 1/24 - Measuring radiation intensity with semiconductor detectors
• C30B 11/00 - Single-crystal-growth by normal freezing or freezing under temperature gradient, e.g. Bridgman- Stockbarger method
• C30B 13/00 - Single-crystal growth by zone-meltingRefining by zone-melting
• C30B 29/12 - Halides

Abstract

Provided are: a positive electrode body of a solid electrolytic capacitor that has a high withstand voltage and a low leakage current; a solid electrolytic capacitor; a method for manufacturing the positive electrode body of the solid electrolytic capacitor; and a method for manufacturing the solid electrolytic capacitor. This positive electrode body comprises: a valve action metal substrate; and a dielectric oxide film on the valve action metal substrate. The dielectric oxide film comprises: a void layer on a surface layer side of the dielectric oxide film; and a void repair layer on the side of the dielectric oxide film that interfaces with the valve action metal substrate. This positive electrode body is formed by first chemical conversion processing, void introduction processing, and second chemical conversion processing. In the first chemical conversion processing, a prescribed chemical conversion voltage is applied to the valve action metal substrate. In the void introduction processing, the positive electrode body is immersed in one or more of an acidic solution, an alkaline solution, and pure water. In the second chemical conversion processing, a chemical conversion voltage lower than that of the first chemical conversion treatment is applied.

IPC Classes  ?

• H01G 9/07 - Dielectric layers
• H01G 9/00 - Electrolytic capacitors, rectifiers, detectors, switching devices, light-sensitive or temperature-sensitive devicesProcesses of their manufacture

Abstract

A pharmaceutical composition for treating peripheral nerve injury, includes a substance that inhibits the formation of neutrophil extracellular traps (NETs) outside the parenchyma of injured peripheral nerves, for example, a substance that inhibits the accumulation of neutrophils in injured peripheral nerves, a substance that suppresses the expression or inhibits the function of macrophage migration inhibitory factor (MIF), etc. Further provided is a method for evaluating the peripheral nerve regeneration-promoting activity of a test substance using, as an indicator, the activity to inhibit the formation of NETs outside the parenchyma of injured peripheral nerves, for example, the activity to inhibit the accumulation of neutrophils in injured peripheral nerves, the activity to suppress the expression of MIF or the activity to inhibit the function thereof, etc.

IPC Classes  ?

• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/42 - Oxazoles
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 38/46 - Hydrolases (3)
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

A method according to the present disclosure is a method of manufacturing a multiplexer/demultiplexer including a substrate, a first port for inputting light, and a second port for outputting light, the first port and the second port being provided in the substrate. The method includes designing positions of a plurality of holes such that three adjacent holes among the plurality of holes are arranged in a triangle lattice, and forming the plurality of holes in a surface of the substrate.

IPC Classes  ?

• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,

Abstract

Provided is a cathode electrode catalyst for ammonia electrosynthesis that contains a perovskite-type metal oxynitride. The perovskite-type metal oxynitride includes, as main metal elements: A, which is at least one element selected from the group consisting of Ba, Sr, and Ca and which contains 50 mol% or more of Ba; and Mo or B, which is at least one element selected from the group consisting of Ta, Nb, and W. The perovskite-type metal oxynitride satisfies a prescribed formula.

IPC Classes  ?

• C25B 11/073 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material
• B01J 27/24 - Nitrogen compounds
• C01C 1/04 - Preparation of ammonia by synthesis
• C25B 1/27 - Ammonia

Abstract

The present disclosure provides an anti-PD-L1 antibody capable of repeated administration even to animals other than rat. The present disclosure further provides a novel therapeutic strategy using an inhibitor targeting PD-1/PD-L1. A pharmaceutical composition which comprises a COX-2 inhibitor and is administered before, after or simultaneously with the administration of an inhibitor targeting PD-1/PD-L1. A potentiator for the immunostimulatory effect of an inhibitor targeting PD-1/PD-L1, which comprises a COX-2 inhibitor. The present disclosure also provides an anti-PD-1 antibody capable of repeated administration even to animals other than rat. An anti-PD-1 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLEYSDGYTY (SEQ ID NO: 164), CDR2 having the amino acid sequence of GVS and CDR3 having the amino acid sequence of FQATHDPDT (SEQ ID NO: 165) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GFSLTSYY (SEQ ID NO: 166), CDR2 having the amino acid sequence of IRSGGST (SEQ ID NO: 167) and CDR3 having the amino acid sequence of ARTSSGYEGGFDY (SEQ ID NO: 168) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above-described anti-PD-1 antibody as an active ingredient. A method for preparing the anti-PD-1 antibody is also provided.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

A particle discrimination mechanism includes: a channel in which a plurality of first nanoparticles each including an absorber having a predetermined absorption level and a plurality of second nanoparticles each of which does not include the absorber having the predetermined absorption level exist, the channel including a first input section and a second input section; a laser that outputs first light, which is absorbed by the absorber having the predetermined absorption level, in a direction from the first input section toward the second input section; a laser that outputs second light, which is not absorbed by the absorber having the predetermined absorption level but is scattered or absorbed by the second nanoparticles, in a direction from the second input section toward the first input section.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Provided is a treatment support system capable of easily determining a radiation treatment device desirable for a patient. An arithmetic processing device 101 predicts a treatment effect index for each treatment modality of a radiation treatment device 202 by using a region of interest which corresponds to a part related to the irradiation of a patient with radioactive ray in a three-dimensional fluoroscopic image showing the patient, and also using parameter information which indicates a value of a parameter for the prediction of a treatment effect index for evaluating the effect of a radiation treatment for each treatment modality of the radiation treatment device 202 for performing the radiation treatment.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

The invention provides a method for combusting of a hybrid rocket fuel, comprising supplying aqueous solution of hydrogen peroxide to a combustion chamber provided with a solid fuel, wherein a concentration of hydrogen peroxide in the aqueous solution of hydrogen peroxide is less than 65% by weight, and the method for combusting comprises at least one of: (i) supplying oxygen and the aqueous solution of hydrogen peroxide to the combustion chamber, and (ii) heating the aqueous solution of hydrogen peroxide before supplying the aqueous solution of hydrogen peroxide to the combustion chamber.

IPC Classes  ?

• F02K 9/72 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant thereforControl thereof using liquid and solid propellants, i.e. hybrid rocket-engine plants
• F23K 5/22 - Vaporising devices

Abstract

The present invention provides lipid nanoparticles each containing a pH-sensitive cationic lipid represented by formula (I) [wherein a represents an integer of 3 to 5; b represents 0 or 1; R1 and R2 each independently represent a group represented by general formula (A) (wherein R11 and R12 each independently represent a linear or branched C1-15 alkyl group; c represents an integer of 1 to 7: and e represents an integer of 4 to 12); and X represents a group represented by general formula (B) (wherein d represents an integer of 0 to 3; and R3 and R4 each independently represent a C1-4 alkyl group or a C2-4 alkenyl group, in which R3 and R4 may be bonded to each other to form a 5- to 7-membered nonaromatic hetero ring) or a 5- to 7-membered nonaromatic hetero ring group]. (R1)(R2)C(OH)-(CH2)a-(O-CO)b-X (I) (R11)(R12)HC-(CH2)c-(CO-O)-(CH2)e-(A) -(CH2)d-N(R3)(R4) (B)

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle

Abstract

It is an object to provide an optical filter, a method of manufacturing an optical filter, a method of designing, a design apparatus, and a program for designing non-transitory computer-readable recording medium which can suppress both the temperature dependency and the waveguide length. An optical filter includes three or more waveguides, and a plurality of sections provided in the three or more waveguides, respectively. Modes of light propagating through the sections of the three or more waveguides are different from each other.

IPC Classes  ?

• G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
• G02B 5/20 - Filters
• G02B 5/28 - Interference filters
• G02B 6/27 - Optical coupling means with polarisation selective and adjusting means

Abstract

Provided is a curette having the function of making it possible to easily confirm the orientation of an affected site surface in a body cavity. This curette comprises: a shaft part 2 that extends in a linear rod shape; and a head part 3 that is provided at the tip end of the shaft part 2. The shaft part 2 is provided with a posture recognition part 5 that, if the head part 3 is at a surface, can recognize the vertical direction n1 of said surface and, if the head part 3 is not at a surface, can recognize the direction in which the tip of the head part is pointing.

IPC Classes  ?

• A61B 17/56 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor

Abstract

A method for generating spectral data according to the present invention involves generating spectral data pertaining to a microparticle sample that includes at least one microparticle, wherein: the method includes a step for acquiring a measurement spectrum from microparticles disposed within a through-hole in a substrate; the through-hole has an inclined structure in which the width continuously decreases from one surface of the substrate toward the other surface thereof; at least part of the inner surface of the through-hole is configured from a metal that exhibits plasmon resonance; and in the step for acquiring the measurement spectrum, the measurement spectrum is acquired while the interior of the through-hole is irradiated with light.

IPC Classes  ?

• G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

The present invention provides an antiviral agent formed from a compound represented by general formula (A-1) or (A-2) shown below [wherein in the formulas, R1 represents O, S, Se or =N—OR11; R2 represents O, S, Se or ═N—OR11; R3 represents —O—R12, —S—R13 or a guanidino group; R11 represents H, an alkyl group or an aryl group; R12 and R13 each independently represent an alkyl group or an aryl group; R4 represents H, —CO—R14 or —O—P(OH)(═O)—O—R15; R14 and R15 each independently represent an alkyl group or an aryl group; R5 and R6 each independently represent H or —CO—R16; and R16 represents an alkyl group of 1 to 6 carbon atoms or an aryl group], a salt of the compound, or a solvate of the compound or salt.

IPC Classes  ?

• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• A61P 31/14 - Antivirals for RNA viruses
• C07H 19/067 - Pyrimidine radicals with ribosyl as the saccharide radical

Abstract

This cement composition for fixing carbon dioxide contains a cement composition and a carbon dioxide absorption liquid containing a carbon dioxide absorbent. This cement hardened body for fixing carbon dioxide includes a cement hardened body and a carbonate carried on the cement hardened body. This method for fixing carbon dioxide has: a step for kneading a carbon dioxide absorption liquid containing a carbon dioxide absorbent into a cement composition; a step for hardening the cement composition containing the carbon dioxide absorbent to obtain a cement hardened body for fixing carbon dioxide; and a step for bringing the atmosphere into contact with the cement hardened body for fixing carbon dioxide, and fixing the carbon dioxide contained in the atmosphere to the cement hardened body for fixing carbon dioxide.

IPC Classes  ?

• C04B 28/02 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing hydraulic cements other than calcium sulfates
• C04B 24/12 - Nitrogen containing compounds
• C04B 40/02 - Selection of the hardening environment

Abstract

Disclosed is a polymer material that comprises: a cyclic polymer which has one or more annular parts; and a crosslinked polymer which has a plurality of linear parts, and in which the plurality of linear parts are bonded to each other at crosslinking points so as to form a crosslinked body. At least some of the cyclic polymers in the polymer material each have an annular part that is penetrated by a linear part of the crosslinked polymer. The ratio of the amount of the cyclic polymer to the amount of the crosslinked polymer may be 15% by mass or more.

IPC Classes  ?

• C08L 101/00 - Compositions of unspecified macromolecular compounds
• C08L 83/04 - Polysiloxanes

Abstract

Provided are: an amino acid compound, for scanning, capable of rapidly synthesizing a modified peptide and assessing the activity of the modified peptide; a modified peptide for scanning; a kit for scanning; and a scanning method for active sites in a peptide. This amino acid compound for scanning is to be used for scanning active sites in a peptide when being introduced so as to substitute a portion of amino acids in a peptide, and is a compound having, in a portion of the structure thereof, a 1,2-amino alcohol or is a substitution product of the same. The present invention also pertains to a modified peptide for scanning, a kit for scanning, and a scanning method for active sites in a peptide.

IPC Classes  ?

• C07C 271/34 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of rings other than six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 31/04 - Antibacterial agents
• C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• C07K 1/04 - General processes for the preparation of peptides on carriers

Abstract

This structural color member (1) has a base material (2) and an oxide film (3) that is formed of a metal oxide and that covers the base material (2). The oxide film (3) includes a porous layer (31) that includes a plurality of pores (311) and that is disposed on the base material (2), and a dense layer (32) that does not include the pores (311) and that is laminated on the porous layer (31). When the thickness of the oxide film (3) is measured at various positions, the thickness of the oxide film (3) at each measurement position is within the ranges of 150 nm to 1000 nm and 0.75 times to 1.25 times the average value of the thickness of the oxide film (3).

IPC Classes  ?

• C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
• B32B 7/023 - Optical properties
• B32B 9/00 - Layered products essentially comprising a particular substance not covered by groups
• C25D 11/26 - Anodisation of refractory metals or alloys based thereon

Abstract

An object is to prevent eavesdropping in quantum key distribution. A synchronization signal reception device receives a synchronization signal that is an optical signal for defining a timing at which a quantum signal is detected, and outputs a reference signal corresponding to the synchronization signal. A clock signal generation unit generates a clock signal in response to the reference signal. A photon detection device detects a photon of the quantum signal in response to the clock signal. A timing of the clock signal randomly changes within a predetermined range.

IPC Classes  ?

• H04L 9/08 - Key distribution
• H04B 10/70 - Photonic quantum communication
• H04L 9/12 - Transmitting and receiving encryption devices synchronised or initially set up in a particular manner

Abstract

This adsorbent contains a copolymer of a cationic functional group-containing monomer or an anionic functional group-containing monomer and an aromatic group-containing monomer, the copolymer having a specific structure in at least a part thereof.

IPC Classes  ?

• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/30 - Processes for preparing, regenerating or reactivating
• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• C08F 8/44 - Preparation of metal salts or ammonium salts
• C08F 220/10 - Esters

Abstract

The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Provided is a compound represented by Formula (I): The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Provided is a compound represented by Formula (I): wherein carbon atom a and carbon atom b are each a carbon atom constituting ring A, the ring A is substituted aromatic carbocycle or the like, R1 is substituted or unsubstituted aromatic heterocyclyl or the like, R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl or the like, m is 1 or the like, R5as are each independently a hydrogen atom or the like, R5bs are each independently a hydrogen atom or the like, n is 1 or the like, R4a is a hydrogen atom or the like, and R4a is a hydrogen atom or the like. Alternatively, provided is a pharmaceutically acceptable salt of the compound.

IPC Classes  ?

• C07D 471/04 - Ortho-condensed systems
• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/5386 - 1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
• A61P 31/14 - Antivirals for RNA viruses
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 487/08 - Bridged systems
• C07D 491/048 - Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

Provided are: a pH-sensitive cationic lipid which can be more easily synthesized through a small number of steps without requiring any organometal reaction or use of any relatively expensive starting materials; and lipid nanoparticles including the lipid. Disclosed is a pH-sensitive cationic lipid comprising a compound represented by general formula (I) or (I'). R1, Z2, s, Z1, and X are as defined in the description.

IPC Classes  ?

• C07D 211/62 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• C07D 295/15 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

A common-mode voltage canceller cancels a common-mode voltage that is generated in accompaniment with operation of an inverter that converts direct-current power to alternating-current power. The common-mode voltage canceller includes a common-mode transformer that generates a cancellation voltage that has a polarity reverse to the common-mode voltage. The common-mode transformer is disposed on a direct-current power line that supplies the direct-current power to the inverter.

IPC Classes  ?

• H02M 1/12 - Arrangements for reducing harmonics from AC input or output
• H02M 1/15 - Arrangements for reducing ripples from DC input or output using active elements
• H02M 1/44 - Circuits or arrangements for compensating for electromagnetic interference in converters or inverters

Abstract

It is provided an area design proposal system for proposing equipment placement and configuration of a regional energy system comprising: a long-term operation optimization module configured to output an optimum solution for the equipment placement and configuration through use of a long-term operation algorithm with input of parameters including energy equipment information, vehicle equipment information, an energy equipment introduction cost, a vehicle introduction cost, and an initial cost upper limit amount; and a short-term operation optimization module configured to calculate short-term operation evaluation results, which are evaluation results of the equipment placement and configuration, through use of a short-term operation algorithm with input of the output from the long-term operation optimization module and short-term environmental fluctuation factors, and wherein the long-term operation optimization module is configured to optimize the equipment placement and configuration with input of the short-term operation evaluation results.

IPC Classes  ?

• G06F 30/18 - Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling

Abstract

Provided is a spatial light modulation device which can be driven at a frame rate higher than that of a two-dimensional light modulator. A spatial light modulation device (10) includes a two-dimensional light modulator (11) including a cell group (C) in which cells are arranged in a matrix manner, and a scanning optical system (cylindrical lens 14, scanning mirror 16, objective lens 17). The scanning optical system repeatedly carries out a first conversion step (S11) of converting a two-dimensional beam (L21) into a one-dimensional beam (L11), a modulation step (S12) of generating a spatially modulated one-dimensional beam (L12), and a second conversion step (S13) of converting the modulated one-dimensional beam (L12) into a two-dimensional beam (L22), while changing a column of the cell group (C) which the one-dimensional beam (L11) is caused to enter in the modulation step (S12).

IPC Classes  ?

• G02B 26/10 - Scanning systems
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

This method for producing fine particles involves hydrolysis in a reaction solution that includes intermediate particles, a hydrolytic enzyme, and a solvent including water, wherein: the intermediate particles have two or more hydrophobic core parts and a linking group linking the two or more core parts; the linking group has a hydrolyzable group; and the hydrolyzable group is hydrolyzed to form fine particles including one or more core parts and having an average particle diameter smaller than the average particle diameter of the intermediate particles.

IPC Classes  ?

• C12P 1/00 - Preparation of compounds or compositions, not provided for in groups , by using microorganisms or enzymesGeneral processes for the preparation of compounds or compositions by using microorganisms or enzymes

Abstract

The present invention pertains to a pharmaceutical composition for preventing or treating refractory bone defects, the pharmaceutical composition comprising: human dental pulp stem cells; and a porous scaffold material having bone-inducing ability. Preferably, the human dental pulp stem cells are cultured together with the scaffold material, and are applied to a bone defect part to assist in the regeneration of bone tissue containing cancellous bone.

IPC Classes  ?

• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane
• A61K 47/02 - Inorganic compounds
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/20 - Polysaccharides
• A61L 27/24 - Collagen
• A61L 27/36 - Materials for prostheses or for coating prostheses containing ingredients of undetermined constitution or reaction products thereof
• A61L 27/38 - Animal cells
• A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

This automatic conveyance system is provided with a plurality of conveyance devices and a management device that manages the plurality of conveyance devices. The management device is capable of executing: a task assignment process for assigning a task to each of the conveyance devices; and a task optimization process for switching conveyance tasks when a conveyance cost is calculated for the case in which assigned conveyance tasks are switched between two of the conveyance devices different from each other and if the calculated conveyance cost is less than a conveyance cost at the time of the task assignment process, or when a conveyance cost is calculated for the case in which the assigned conveyance tasks and unassigned conveyance tasks are switched and if the calculated conveyance cost is less than a conveyance cost in which the unassigned conveyance tasks are assigned to any of the conveyance devices. The management device executes the task optimization process while the conveyance devices processes the tasks assigned by the task assignment process.

IPC Classes  ?

• B65G 1/00 - Storing articles, individually or in orderly arrangement, in warehouses or magazines
• B65G 1/137 - Storage devices mechanical with arrangements or automatic control means for selecting which articles are to be removed

Abstract

Disclosed is a combination vaccine for the prevention of influenza and new coronavirus infections. As a combination vaccine for vaccination against influenza and new coronaviruses, an inactivated whole virus particle vaccine, in which viral particles of an influenza virus and viral particles of a new coronavirus are inactivated respectively, is prepared. This vaccine induces neutralizing antibodies against the respective viruses without affecting vaccine effects so that protective effects against the attacks of the respective viruses are obtained. Further, the combination vaccine having this combination well induces neutralizing antibodies and exhibits protective effects against the attacks of the viruses even without adding an adjuvant.

IPC Classes  ?

• A61K 39/145 - Orthomyxoviridae, e.g. influenza virus
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses
• A61P 37/04 - Immunostimulants

Abstract

The present invention provides a composition for inducing immune tolerance, the composition containing: pluripotent stem cells that have the ability to form teratoma cells; or teratoma cells derived from the pluripotent stem cells. The present invention also provides a method for inducing immune tolerance in a mammalian individual, the method including administering an effective amount of the pluripotent stem cells or the teratoma cells to a mammal individual for which immune tolerance is desired. By inducing immune tolerance in a mammalian individual by an immune-tolerance-inducing composition and an immune tolerance inducer, autoimmune diseases can be treated and allogeneic transplantation can be performed under a condition in which a reduced amount of an immunosuppressant is used compared to the amount conventionally used, or under a condition in which no immunosuppressant is used.

IPC Classes  ?

• A61K 35/545 - Embryonic stem cellsPluripotent stem cellsInduced pluripotent stem cellsUncharacterised stem cells
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C12N 5/09 - Tumour cells
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 5/0735 - Embryonic stem cellsEmbryonic germ cells

Abstract

It is desirable to provide a novel biomaterial and the like for tendon repair. Provided is a biomaterial for tendon repair containing a hydrogel formed by means of a cross-linking reaction between a reactive group A and a reactive group B, wherein the hydrogel contains a water-soluble polymer having the reactive group A, and mesenchymal stem cells having the reactive group B.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/20 - Polysaccharides
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

Provided is a microbial nucleic acid detection method, etc., that permits fast, easy, and highly accurate measurement of the concentration of a target nucleic acid and can also ensure an adequate measurement range (dynamic range). The microbial nucleic acid detection method comprises: a step in which a probe solution, which is a solution of a gold nanoparticle probe in which DNA that binds specifically to the target nucleic acid is modified with gold nanoparticles, is mixed with an extract obtained by subjecting a sample to nucleic acid extraction treatment, sodium chloride, at least, is also added and the mixture is heated to prepare a sample mixed solution; a step in which an absorption spectrum of the probe solution is acquired; a step in which an absorption spectrum of a blank solution is acquired, the blank solution being is a sample-free solution obtained by adding sodium chloride to the probe solution and heating; a step in which an absorption spectrum of the sample mixed solution is acquired; and a calculation step in which the concentration of the target nucleic acid in the sample is estimated based on the absorption spectra of the probe solution, the blank solution, and the sample mixed solution.

IPC Classes  ?

• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

HAlHAlAl of the mass ratio of aluminum atoms in the range from the surface of the protective film (3) to a position at a depth of 1 μm is 0.2-0.7.

IPC Classes  ?

• C25D 11/18 - After-treatment, e.g. pore-sealing

Abstract

The present invention enables highly accurate markerless tracking of tumor movement on the basis of a real-time image. A movement tracking device that tracks the movement of a target and a tissue in a specific region is provided, comprising: a movement estimating unit that acquires an estimated 3D motion which is obtained by estimating a three-dimensional movement of the target and the tissue on a real-time basis, and an estimated 2D motion which is obtained by estimating a two-dimensional movement of the target and the tissue on a real-time basis; an image acquisition unit that acquires a reference 2D image which is a two-dimensional image of the specific region at a predetermined reference time and a real-time 2D image which is a two-dimensional image of the specific region at real time; an image simulator that uses the estimated 2D motion and the reference 2D image to generate a pseudo real-time 2D image that simulates the two-dimensional image of the specific region at real time; and an estimation correction unit that corrects the estimated 3D motion on the basis of a comparison between the pseudo real-time 2D image and the real-time 2D image.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A phase modulator calibration method includes steps of: providing a first delay interferometer to be used as a phase calibration reference and a second delay interferometer in which a phase modulator to be calibrated is installed in an optical path; for each of the first and second delay interferometers, measuring a delay time based on a time interval between pulses split from one input pulse and synchronizing the delay time with a cycle of a transmission clock; for the first delay interferometer, adjusting a phase difference so that input continuous-wave laser light produces an intensity-enhancing interference at an output; and determining the control signal with a calibration circuitry formed by connecting the first delay interferometer as a front stage and the second delay interferometer as a rear stage in a cascaded manner.

IPC Classes  ?

• G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference

Abstract

6486488O including slightly oxidized copper-coated copper particles being slightly oxidized copper particles having an average particle diameter of 1 nm to 20 nm inclusive and a medium, wherein the content of the slightly oxidized copper-coated copper particles is greater than 85 mass %.

IPC Classes  ?

• C09J 1/00 - Adhesives based on inorganic constituents
• B22F 1/00 - Metallic powderTreatment of metallic powder, e.g. to facilitate working or to improve properties
• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 1/14 - Treatment of metallic powder
• B22F 7/08 - Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting of composite workpieces or articles from parts, e.g. to form tipped tools with one or more parts not made from powder
• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys

Abstract

The present invention addresses the problem of providing: (i) a reduction method for reducing a substrate, which is composed of one or more compounds each having an unsaturated bond, by means of a mechanochemical treatment using at least a proton source and a metal including one or more elements selected from among alkali metals and alkaline earth metals; and (ii) a reduction method which enables the achievement of a reaction product that is similar to the reaction product by Birch reduction, with which the reaction can be carried out under mild temperature conditions in the ambient atmosphere without using liquid ammonia and high activity in the reduction reaction can be exhibited without using any solvent or substantially without using an organic solvent, and which enables the achievement of a reaction product with a high yield within a short time by a simple operation and is applicable to a wide range of substrates. The present invention provides, as a means for solving the problem, a reduction method for reducing a substrate (A) by a mechanochemical treatment using at least a metal (B) and a proton source (C), wherein: the substrate (A) is composed of one or more compounds each having an unsaturated bond; and the metal (B) includes one or more elements that are selected from among alkali metals and alkaline earth metals.

IPC Classes  ?

• C07C 5/11 - Partial hydrogenation
• C07B 31/00 - Reduction in general
• C07B 35/02 - Reduction
• C07C 5/05 - Partial hydrogenation
• C07C 13/23 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring with a cyclohexadiene ring
• C07C 13/48 - Completely or partially hydrogenated naphthalenes
• C07C 13/58 - Completely or partially hydrogenated anthracenes
• C07C 13/547 - Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with three condensed rings at least one ring not being six-membered, the other rings being at the most six-membered
• C07C 15/18 - Polycyclic non-condensed hydrocarbons containing at least one group with formula
• C07C 29/19 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds in six-membered aromatic rings
• C07C 33/14 - Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
• C07C 41/20 - Preparation of ethers by reactions not forming ether-oxygen bonds by hydrogenation of carbon-to-carbon double or triple bonds
• C07C 43/303 - Compounds having groups having acetal carbon atoms bound to acyclic carbon atoms
• C07C 51/36 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
• C07C 57/26 - Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07C 233/05 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• C07C 269/04 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
• C07C 271/12 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Abstract

Provided is a sulfide solid electrolyte that has a novel crystal structure and exhibits an ionic conductivity, the sulfide solid electrolyte containing a lithium atom, a phosphorus atom, a sulfur atom, and at least one kind of halogen atom selected from a chlorine atom and a bromine atom, and having a specific diffraction peak in powdery X-ray diffractometry using CuKα line, and a method for producing a sulfide solid electrolyte, the method including mixing a solvent 1 having a heteroatom and a raw material 1 containing specific atoms to prepare a mixture, preparing a solution that contains a raw material 2 containing a halogen atom and a solvent 2 having a heteroatom, mixing the mixture and the solution to prepare a fluid, and heating the fluid.

IPC Classes  ?

• H01M 10/0562 - Solid materials
• C01B 25/14 - Sulfur, selenium, or tellurium compounds of phosphorus

Abstract

Provided is a reaction heat utilization system capable of enhancing temperature controllability in a reactor and utilizing reaction heat generated in the reactor with higher efficiency. This reaction heat utilization system comprises: a reactor that accommodates a heat storage unit including a plurality of latent heat storage bodies; a supply unit that supplies one of a first fluid and a second fluid to the reactor in a switchable manner; and a discharge unit that discharges generated fluid generated through a chemical reaction from the reactor. Each latent heat storage body has a core part including a latent heat storage material, and a shell part that has a melting point higher than that of the latent heat storage material and that seals the latent heat storage material therein. The first fluid includes a starting fluid that causes an exothermic reaction in the reactor and/or the second fluid includes a starting fluid that causes an endothermic reaction in the reactor. The reaction heat utilization system is configured to switch alternately between a heat storage mode in which heat is stored in the heat storage unit as a result of the first fluid being supplied from the supply unit to the reactor, and a heat radiation mode in which heat is released from the heat storage unit as a result of the second fluid being supplied from the supply unit to the reactor.

IPC Classes  ?

• F28D 20/02 - Heat storage plants or apparatus in generalRegenerative heat-exchange apparatus not covered by groups or using latent heat
• C07C 1/04 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon monoxide with hydrogen
• C07C 1/22 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only oxygen atoms as hetero atoms by reduction
• C07C 9/04 - Methane

Abstract

Disclosed is a ceramic reversible cell which contains at least one substance selected from the group consisting of perovskite type metal oxides, hydrates of the perovskite type metal oxides, and hydrides of the perovskite type metal oxides, wherein: the at least one substance selected from the group consisting of perovskite type metal oxides, hydrates of the perovskite type metal oxides, and hydrides of the perovskite type metal oxides contains A (wherein A is at least one element selected from the group consisting of Ba, Sr and Ca), B (wherein B is at least one element selected from the group consisting of Zr, Sn, Ce, Ti and Hf) and M (wherein M is at least one element selected from the group consisting of In, Fe, Cr and Mn) as main metal atoms; and hydride ions are contained therein when equilibrium is reached by bringing dried hydrogen into contact with the ceramic reversible cell, the dried hydrogen satisfying a specific formula and having a moisture content of 20 ppm or less in terms of volume ratio at 500°C to 900°C.

IPC Classes  ?

• C25B 13/07 - DiaphragmsSpacing elements characterised by the material based on inorganic materials based on ceramics
• C01G 25/02 - Oxides
• C04B 35/50 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on rare earth compounds
• C04B 35/488 - Composites
• C25B 1/042 - Hydrogen or oxygen by electrolysis of water by electrolysis of steam
• C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 13/04 - DiaphragmsSpacing elements characterised by the material
• H01M 8/12 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte
• H01M 8/1246 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides

Abstract

[Problem] To provide a screening method for candidate compounds capable of serving as a preventive or therapeutic agent for suppressing individual deaths of honeybees due to viral infection and to provide a preventive or therapeutic agent tied to suppression of honeybee mass deaths due to viral infection. [Solution] The cause of mass deaths of honeybee was identified as intestinal tract damage due to a virus-derived protease mediated by mites, and it was discovered that individual deaths and intestinal tract damage were suppressed in the virus infection group by administration of viral dsRNA. Furthermore, it was discovered that individual deaths in the virus infection group were suppressed by inhibiting the virus-derived protease by administering E-64 ([(2S,3S)-3-carboxyoxylan-2-carbonyl]-L-leucine (4-guanidinobutyl) amide hemihydrate).

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• A61K 31/336 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
• A61P 31/12 - Antivirals
• C12Q 1/37 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving peptidase or proteinase

Abstract

Provided are a lignin degradation catalyst that exhibits excellent lignin degradability and that is readily separated after degradation reaction, a method for producing the catalyst, and a method for degrading lignin. The lignin degradation catalyst according to the present invention contains a substrate and at least one metal compound immobilized on the substrate, wherein the at least one metal compound contains a copper compound. The method for producing a lignin degradation catalyst according to the present invention includes the step of brining a porous copper substrate into contact with a solution containing an oxidant to obtain a substrate having a copper compound immobilized thereon, or the step of subjecting a porous copper substrate to electro-oxidation to obtain a substrate having a copper compound immobilized thereon.

IPC Classes  ?

• B01J 23/889 - Manganese, technetium or rhenium
• B01J 23/72 - Copper
• B01J 23/755 - Nickel
• B01J 23/83 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with rare earths or actinides
• B01J 23/94 - Regeneration or reactivation of catalysts comprising metals, oxides or hydroxides of the iron group metals or copper
• B01J 35/56 - Foraminous structures having flow-through passages or channels, e.g. grids or three-dimensional monoliths
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 38/02 - Heat treatment
• C07C 41/01 - Preparation of ethers
• C07C 45/32 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by oxidation with molecular oxygen
• C07C 51/21 - Preparation of carboxylic acids or their salts, halides, or anhydrides by oxidation with molecular oxygen

Abstract

[Problem] To provide a metal heating furnace and a method for combusting ammonia by using a metal heating furnace, whereby it becomes possible to combust ammonia while effectively reducing nitrogen oxides. [Solution] Provided is a metal heating furnace 10 in which ammonia is combusted as a fuel with fire F from a burner nozzle 31 provided in a furnace wall 11. The metal heating furnace 10 is provided with: a plurality of ammonia injection nozzles 41, 42, 43 which are arranged at intervals in the fire F-extending direction in a ceiling wall 13 and through which ammonia is injected in a direction orthogonal to the fire F-extending direction; and a control device 100 which adjusts the amounts of ammonia to be ejected through the ammonia ejection nozzles 41, 42, 43 for every ammonia ejection nozzle 41, 42, 43.

IPC Classes  ?

• F27D 7/02 - Supplying steam, vapour, gases or liquids
• F23C 1/00 - Combustion apparatus specially adapted for combustion of two or more kinds of fuel simultaneously or alternately, at least one kind of fuel being either a fluid fuel or a solid fuel suspended in air
• F23C 99/00 - Subject matter not provided for in other groups of this subclass
• F23D 14/02 - Premix gas burners, i.e. in which gaseous fuel is mixed with combustion air upstream of the combustion zone
• F23J 7/00 - Arrangement of devices for supplying chemicals to fire
• F23K 5/00 - Feeding or distributing other fuel to combustion apparatus
• F23N 1/00 - Regulating fuel supply
• F27B 5/16 - Arrangements of air or gas supply devices
• F27B 5/18 - Arrangement of controlling, monitoring, alarm or like devices

Abstract

The present invention provides: lipid nanoparticles that are for editing mitochondrial genome and that each include an RNA-guided DNA nuclease and a guide RNA; and a dispersion containing, in a dispersion medium, said lipid nanoparticles as a dispersoid. The present invention also provides a pharmaceutical composition that contains said lipid nanoparticles and that is for preventing or treating mitochondrial diseases, particularly a pharmaceutical composition for preventing or treating MELAS. The present invention further provides methods for producing the lipid nanoparticles and the dispersion.

IPC Classes  ?

• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• A61K 9/10 - DispersionsEmulsions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/51 - Nanocapsules
• A61K 38/46 - Hydrolases (3)
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 15/09 - Recombinant DNA-technology

Abstract

A water electrolysis electrode for use in a water electrolysis device in which a hydrogen-producing reaction electrode and an oxygen-producing reaction electrode are brought into contact with water and a voltage is applied between both electrodes to produce hydrogen and oxygen, said water electrolysis electrode having, on at least a portion of a surface thereof, one or more structures selected from the group consisting of a plurality of nanostructures and a plurality of microstructures which, during water electrolysis, interact with at least one type of polarization selected from the group consisting of electronic polarization of a chemical reaction intermediate during water electrolysis and vibrational polarization of water molecules.

IPC Classes  ?

• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
• C25B 11/04 - ElectrodesManufacture thereof not otherwise provided for characterised by the material

Abstract

Provided is a magnetic core in which power feeding efficiency and robustness against position error are increased. A magnetic core of the present disclosure comprises: a base portion; a column portion extending upward from the base portion; a cap portion connected to the column portion; and a wall portion extending upward from the base portion and provided to surround the column portion in plan view. The cap portion opposes the base portion in the vertical direction, and extends outside the column portion in plan view. The cap portion is smaller than the base portion in plan view, and is positioned inside the outer edge of the wall portion. The upper end of the wall portion is positioned lower than the upper surface of the cap portion.

IPC Classes  ?

• H01F 27/24 - Magnetic cores
• H01F 38/14 - Inductive couplings
• H02J 50/10 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
• H02J 50/90 - Circuit arrangements or systems for wireless supply or distribution of electric power involving detection or optimisation of position, e.g. alignment

Abstract

This life design proposal system comprises a computer having a calculation device that executes a predetermined calculation process, and a storage device connected to the calculation device, wherein the calculation device includes a reception unit that receives a life plan desired by a user and a balance of well-being desired by the user; an extraction unit that extracts a subject that matches the received life plan; and an output unit that outputs data on a plurality of role models including the age at which a life event occurred and well-being at the time of each life event, on the basis of the satisfaction level of the extracted subject in the life events.

IPC Classes  ?

• G06Q 50/10 - Services

Abstract

This forceps system comprises: a tubular guide sheath (2); a forceps (3) that has an openable and closable gripping section (7), and is inserted into the guide sheath (2) in the longitudinal direction of the guide sheath (2); and an orientation adjustment mechanism (8, 9) that is provided in the guide sheath (2) and the forceps (3), and adjusts the orientation of the gripping section (7) relative to the guide sheath (2). The guide sheath (2) has a shielding section (4) provided in a circumferential portion of a tip end part of the guide sheath (2). The orientation adjustment mechanism (8, 9) adjusts the gripping section (7) disposed at the tip end part of the guide sheath (2) to a predetermined orientation where the openable and closable side of the gripping section (7) faces away from the shielding section (4).

IPC Classes  ?

• A61B 17/29 - Forceps for use in minimally invasive surgery
• A61B 10/06 - Biopsy forceps

Abstract

[Problem] To provide an industrial furnace that can combust ammonia effectively and facilitate reduction in nitrogen oxides. [Solution] An industrial furnace 1 uses flame F from a burner 10 to combust ammonia which is supplied along with combustion air and fuel gas to the burner 10. Tips of tube-shaped ammonia injection nozzles 21, 22, 23, 24, which are arranged in communication with the wall surface of a furnace body 2 in the furnace 1 and which are provided so as to inject only ammonia, are protruded inward to the furnace body 2 from the wall surface. The entirety of the ammonia injection nozzles 21, 22, 23, 24 are formed by using a catalyst C which decomposes ammonia into hydrogen and nitrogen.

IPC Classes  ?

• F23K 5/00 - Feeding or distributing other fuel to combustion apparatus
• F23C 1/00 - Combustion apparatus specially adapted for combustion of two or more kinds of fuel simultaneously or alternately, at least one kind of fuel being either a fluid fuel or a solid fuel suspended in air
• F23C 13/08 - Apparatus in which combustion takes place in the presence of catalytic material characterised by the catalytic material
• F23K 5/08 - Preparation of fuel
• F23K 5/10 - Mixing with other fluids

Abstract

The present invention relates to manganese dioxide suitable as a raw material of an electrode material for a polyvalent metal ion secondary battery. The manganese dioxide according to the present invention has an α-type crystal structure. Ammonium ions are incorporated in the α-type crystal structure. The manganese dioxide according to the present invention has an average crystallite size of at most 5.0 nm, as measured using the Scherrer method based on X-ray diffraction, and a BET specific surface area of at least 100 m2/g.

IPC Classes  ?

• C01G 45/02 - Oxides
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium

Abstract

A solid material sustainedly releasing ethylene gas, the solid material comprising a silver-containing zeolite and a dehydrating agent, wherein a layer comprising the silver-containing zeolite and a layer comprising the dehydrating agent are preferably arranged so that the ethylene gas released from the silver-containing zeolite passes through the layer comprising the dehydrating agent.

IPC Classes  ?

• C09K 3/00 - Materials not provided for elsewhere
• A23B 7/152 - Preserving or ripening with chemicals not covered by group or in the form of gases, e.g. fumigationCompositions or apparatus therefor in a controlled atmosphere comprising other gases in addition to CO2, N2, O2 or H2O
• A23L 19/12 - Products from fruits or vegetablesPreparation or treatment thereof of tuberous or like starch containing root crops of potatoes
• C01B 39/14 - Type A
• C01B 39/22 - Type X

Abstract

The present invention relates to manganese dioxide suitable as a raw material of an electrode material for a polyvalent metal ion secondary battery. The manganese dioxide according to the present invention has an α-type crystal structure. Ammonium ions are incorporated in the α-type crystal structure. The manganese dioxide according to the present invention has an average crystallite size of at most 5.0 nm, as measured using the Halder-Wagner method based on X-ray diffraction, and a BET specific surface area of at least 100 m2/g.

IPC Classes  ?

• C01G 45/02 - Oxides
• H01M 4/48 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides
• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium

Abstract

A treatment planning system is configured to create a treatment planning for radiotherapy and includes a processing device and a memory. The memory stores a plurality of calculation models, and the processing device uses at least two of the plurality of calculation models to calculate calculation values of biological effect indices representing an effect of radiotherapy with respect to a condition for radiotherapy, and searches for the condition so that at least two of the calculation values to be calculated approach a predetermined target value.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

There are provided a method for detecting amyloid-β bound to a brain-neuronal-cell-derived exosome in blood, the method including: a step of binding amyloid-β bound to the brain-neuronal-cell-derived exosome in blood to an amyloid-β-specific binding substance that specifically binds to amyloid-β, labeled with a nucleic acid fragment; and a step of detecting the amyloid-β-specific binding substance, and a method for evaluating an accumulation level of amyloid-β in a brain, the method including: a step of detecting amyloid-β bound to the brain-neuronal-cell-derived exosome in blood; and a step of evaluating an accumulation level of amyloid-β in a brain based on the detected amount of the amyloid-β.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: Polyoxyethylene derivatives represented by the following formula (1) provided by the present invention: wherein the symbols in the formula are as defined in the specification, can form conjugates with polypeptide that can be degraded over a long time under physiological conditions to release the polypeptide.

IPC Classes  ?

• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• C12N 9/22 - Ribonucleases

Abstract

The present disclosure is directed to an ignition device including a housing, a bulk fuel, and at least two lead wires as electrodes. The bulk fuel is made of a plastic material, such as polylactic acid (PLA) or epoxy resin. The bulk fuel contains an internally dispersed powdery conductive material, thereby obtaining a conductive solid fuel. One end of the lead wire is partially embedded in the bulk fuel. The other end of the lead wire is connected to a power source. A portion of the bulk fuel is gasified by energizing the lead wire, and the gasified fuel is combusted by reaction with an oxidant.

IPC Classes  ?

• F02K 9/95 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant thereforControl thereof characterised by starting or ignition means or arrangements
• F02K 9/08 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant thereforControl thereof using solid propellants

Abstract

Provided are a diagnosis method and a testing method for muscular dystrophy in cats. The diagnosis method is for determining whether a cat under examination has developed muscular dystrophy, wherein information about the dystrophin gene of the cat under examination is acquired from a biological sample collected from the cat under examination, and on the basis of the information, it is determined whether the cat under examination has developed muscular dystrophy. Further, the testing method is for determining whether a cat under examination or a descendant thereof has a risk of developing muscular dystrophy, wherein information about the dystrophin gene of the cat under examination is acquired from a biological sample collected from the cat under examination, and on the basis of the information, it is determined whether the cat under examination or a descendant thereof has a risk of developing muscular dystrophy.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• A01K 67/02 - Breeding vertebrates
• C12N 15/12 - Genes encoding animal proteins
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

The present invention relates to a method for comprehensively detecting autoantigens of an immune-mediated disease in a short period of time. A method for detecting autoantigens of an immune-mediated disease according to the present invention comprises: a step for bringing antibodies obtained from an immune-mediated-disease sample, and a lysate of animal tissue, into contact with each other; a step for eluting proteins that are bonded to the antibodies; and a step for performing mass spectrometry of the eluted proteins without performing electrophoresis.

IPC Classes  ?

• G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The purpose of the present disclosure is to provide a pharmaceutical composition having an excellent therapeutic effect on the treatment of central nervous system diseases.　A pharmaceutical composition for transnasal administration to be used for treating central nervous system diseases and containing a purified product of extracellular vesicles, in which the purified product of extracellular vesicles is obtained by a method for producing a purified product of extracellular vesicles, the method comprising: (i) a purification step in which a solution to be treated containing extracellular vesicles and foreign substances is brought into contact with an exclusive anion exchange carrier to obtain a treated solution containing the extracellular vesicles; and (ii) a membrane filtration step in which the treated solution is subjected to membrane filtration to obtain a concentrated solution of the extracellular vesicles. The pharmaceutical composition for transnasal administration has an excellent therapeutic effect on the treatment of central nervous system diseases.

IPC Classes  ?

• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• B01D 61/14 - UltrafiltrationMicrofiltration
• B01D 61/16 - Feed pretreatment
• B01D 61/22 - Controlling or regulating
• B01D 63/02 - Hollow fibre modules
• B01J 41/10 - Inorganic material
• B01J 41/13 - Macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 41/16 - Cellulose or woodDerivatives thereof
• B01J 41/18 - Carbon, coal or tar
• B01J 41/20 - Anion exchangers for chromatographic processes

Abstract

The present invention provides lipid nanoparticles that contain a pH-sensitive cationic lipid and a polyalkylene glycol-modified lipid. The pH-sensitive cationic lipid fraction of the total lipids that constitute the lipid nanoparticles is 10-25 mol %, the polyalkylene glycol-modified lipid fraction of the total lipids that constitute the lipid nanoparticles is 0.5-1.75 mol %, and the number average particle size of the lipid nanoparticles is at least 150 nm.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders

Abstract

A dispersion for an X-ray target in which gold nanoparticles and sodium alginate or a calcium phosphate-based bone reinforcing material are dispersed, in which the gold nanoparticles are in contact with the sodium alginate or the calcium phosphate-based bone reinforcing material.

IPC Classes  ?

• A61K 49/04 - X-ray contrast preparations

Abstract

[Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties. [Problem] To provide an ultrasonic physical properties measurement device that suppresses the generation of a secondary flow inside a cylinder, is more portable, and can suppress changes in physical properties. [Solution] An ultrasonic physical properties measurement device 1 that: uses ultrasonic waves to measure the flow velocity profile of fluids that flow inside a cylinder 2, by rotating the cylinder 2 backwards and forwards in a fixed cycle; and calculates the physical properties of fluid from the flow velocity profile. The cylinder 2: has an upper end surface 21 and lower end surface 22 that are penetrated such that fluid can flow therethrough; and comprises a rotation mechanism 3 that supports all or part of the cylinder 2 in a state of immersion in the fluid and rotates the cylinder 2 backwards and forwards.

IPC Classes  ?

• G01F 1/66 - Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by measuring frequency, phase shift or propagation time of electromagnetic or other waves, e.g. using ultrasonic flowmeters

Abstract

A cell mass-forming member that is capable of easily forming a cell mass and superior in industrial mass productivity; a culture container equipped with the cell mass-forming member; a method for producing cultured cells using the cell mass-forming member; and cultured cells with a cell mass-forming member that are equipped with the cell mass-forming member. The cell mass-forming member has a base material, an adhesion inhibition area and a cell adhesion area are formed on the surface of the base material; a micro-concavo-convex structure area including a plurality of convex portions is formed in the cell adhesion area; and a hydrophilic coating layer is formed on both the adhesion inhibition area and the cell adhesion area. The culture container and the cultured cells with a cell mass-forming member are equipped with the cell mass-forming member. The method for producing cultured cells includes using the cell mass-forming member.

IPC Classes  ?

• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
• C12N 5/09 - Tumour cells

Abstract

The problem addressed is: to provide a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material as a radical initiator for reactions in which the polymer mechanoradical initiator component is not incorporated into the reaction product; to provide a reaction method for radical reduction of an organic halogen compound using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material; to provide a reaction method for radical cyclization of an organic halogen compound using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material; or to provide a reaction method for C-H fluorination of a compound having a C-H bond based on a secondary carbon or a tertiary carbon using a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material. Provided as a solution are: (i) a polymer mechanoradical initiator obtained by mechanochemical treatment of an organic polymer material, wherein the polymer mechanoradical initiator is used in reactions in which the polymer mechanoradical initiator is not incorporated into the reaction product; (ii) a reaction method for radical reduction and/or radical cyclization of a substrate using a polymer mechanoradical initiator, wherein the reaction method includes a step that performs mechanochemical treatment of at least an organic polymer material and a substrate inside a reactor and the substrate contains an organic halogen compound; and (iii) a reaction method for C-H fluorination of a substrate using a polymer mechanoradical initiator, wherein the reaction method includes a step that performs mechanochemical treatment of at least an organic polymer material, a substrate, and a fluorination reagent inside a reactor and the substrate contains a compound having a C-H bond based on a secondary carbon or a tertiary carbon.

IPC Classes  ?

• C07B 61/00 - Other general methods
• C07B 31/00 - Reduction in general
• C07C 5/00 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
• C07C 9/15 - Straight-chain hydrocarbons
• C07C 13/567 - FluorenesCompletely or partially hydrogenated fluorenes
• C07C 13/615 - Adamantanes
• C07C 15/14 - Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
• C07C 15/24 - Polycyclic condensed hydrocarbons containing two rings
• C07C 15/30 - Phenanthrenes
• C07C 17/23 - Preparation of halogenated hydrocarbons by dehalogenation
• C07C 23/02 - Monocyclic halogenated hydrocarbons
• C07C 25/18 - Polycyclic aromatic halogenated hydrocarbons
• C07C 45/65 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by splitting-off hydrogen atoms or functional groupsPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by hydrogenolysis of functional groups
• C07C 49/78 - Acetophenone
• C07C 209/74 - Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
• C07C 211/54 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
• C07D 209/30 - IndolesHydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
• C07D 209/82 - CarbazolesHydrogenated carbazoles
• C07D 307/06 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
• C07D 307/79 - Benzo [b] furansHydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
• C07D 309/10 - Oxygen atoms
• C07D 333/76 - Dibenzothiophenes

Abstract

[Problem] To provide an industrial furnace which burns ammonia effectively while achieving a reduction in nitrogen oxides, without a particular increase in cost. [Solution] In an industrial furnace 100 equipped with a regenerative burner comprising a pair of burners 10, 20: air nozzles 11, 21 for discharging combustion air into the furnace are provided in furnace walls 101, 102 in positions at the centers of the burners 10, 20; fuel nozzles 12, 22 for discharging a fossil fuel into the furnace are provided on one of two sides sandwiching the air nozzles 11, 21, and ammonia nozzles 13, 23 for discharging ammonia into the furnace are provided on the other side; and the ammonia is burned using the burners 10, 20.

IPC Classes  ?

• F23D 14/22 - Non-premix gas burners, i.e. in which gaseous fuel is mixed with combustion air on arrival at the combustion zone with separate air and gas feed ducts, e.g. with ducts running parallel or crossing each other
• F23C 1/00 - Combustion apparatus specially adapted for combustion of two or more kinds of fuel simultaneously or alternately, at least one kind of fuel being either a fluid fuel or a solid fuel suspended in air
• F23D 14/84 - Flame spreading or otherwise shaping
• F23L 15/00 - Heating of air supplied for combustion
• F23L 15/02 - Arrangements of regenerators
• F27D 7/02 - Supplying steam, vapour, gases or liquids

Abstract

An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.] An object of the present invention is to provide an industrially easily available hatching factor on Globodera pallida larvae, a control agent and a control method using the same. The Globodera pallida control agent of the present invention contains, as an active ingredient, at least one selected from a compound of formula (I) below, a stereoisomer thereof, and a salt thereof [wherein Ar represents a substituted or unsubstituted phenyl group or the like; R1 each independently represents a group such as a substituted or unsubstituted C1 to 6 alkyl group and a substituted or unsubstituted C2 to 6 alkenyl group; R2 represents a hydrogen atom or a substituted or unsubstituted C1 to 6 alkyl group; the partial structure —Y—X— represents a group represented by *—N(Rb)—C(═X1)—**; X1 each independently represents an oxygen atom or a sulfur atom; Rb represents hydrogen atom or the like; where * indicates a binding position to the carbon atom having two R1, and ** indicates a binding position to Z; and Z represents a substituted or unsubstituted methylene group, or a substituted or unsubstituted dimethylene group.]

IPC Classes  ?

• A01N 43/18 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with sulfur as the ring hetero atom
• A01N 43/08 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with oxygen as the ring hetero atom
• A01N 43/10 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom five-membered rings with sulfur as the ring hetero atom
• A01N 43/36 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
• A01N 43/38 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
• A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
• A01N 43/80 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms, as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
• A01P 5/00 - Nematocides

Abstract

A catalyst structure for synthesis gas production is used to produce a synthesis gas that includes carbon monoxide and hydrogen. The structure includes a carrier with a porous structure that comprises a zeolite-type compound; first catalyst particles that contain at least one iron-group element selected from the group consisting of nickel, iron, and cobalt; and a second catalyst that contains at least one transition metal element with redox capacity. The carrier includes, inside thereof, mutually communicating passages; the first catalyst particles are present at least in the passages of the carrier; and the second catalyst is present at least in the interior or on an outer surface of the carrier.

IPC Classes  ?

• B01J 29/035 - Crystalline silica polymorphs, e.g. silicalites
• B01J 35/45 - Nanoparticles
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/10 - Heat treatment in the presence of water, e.g. steam
• C01B 3/40 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of gaseous or liquid organic compounds with gasifying agents, e.g. water, carbon dioxide, air by reaction of hydrocarbons with gasifying agents using catalysts characterised by the catalyst

Abstract

The present invention addresses the problem of providing a method for producing a homo-coupling reaction product, whereby it becomes possible to substantially eliminate the use of an organic solvent, to carry out a reaction under a mild reaction condition by a simple reaction operation, to use a broad range of organic halogen compounds as starting materials, to produce a reaction product within a short time with high yield, and to produce a reaction product having a higher molecular weight. As a solution for the problem, a method for producing a homo-coupling reaction product of an organic halogen compound represented by formula (I): A1mm (wherein A1 represents any one of an m-valent aromatic hydrocarbon group which may have a substituent, an m-valent aromatic heterocyclic group which may have a substituent, an m-valent heterocyclic group which may have a substituent, an m-valent aliphatic hydrocarbon group which may have a substituent, and an m-valent unsaturated aliphatic hydrocarbon group which may have a substituent; X represents any one of a chlorine atom, a bromine atom and an iodine atom, in which, when there are a plurality of X's, the X's may be the same as or different from each other; and m represents the number of X's and is an integer of 1 or more) is provided, in which the organic halogen compound represented by formula (I) is reacted by a mechano-chemical method in the presence of a nickel catalyst under the following condition (a) and/or the following condition (b). Condition (a): the amount of a solvent to be used is 0.8 mL or less relative to 1 mmol of the organic halogen compound. Condition (b): a hetero-atom-containing compound is present.

IPC Classes  ?

• C07B 37/04 - Substitution
• C07B 61/00 - Other general methods
• C07C 1/26 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon starting from organic compounds containing only halogen atoms as hetero atoms
• C07C 15/14 - Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
• C07C 15/38 - Polycyclic condensed hydrocarbons containing four rings
• C07C 15/52 - Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic part substituted by unsaturated hydrocarbon radicals polycyclic non-condensed containing a group with formula
• C07C 41/30 - Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
• C07C 43/205 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a non-condensed ring
• C07C 45/68 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton by increase in the number of carbon atoms
• C07C 49/784 - Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
• C07C 67/343 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisationPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by change of size of the carbon skeleton by increase in the number of carbon atoms
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 209/68 - Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
• C07C 211/54 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
• C07C 255/51 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings containing at least two cyano groups bound to the carbon skeleton
• C07D 209/82 - CarbazolesHydrogenated carbazoles
• C07D 295/135 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• C07D 333/52 - Benzo [b] thiophenesHydrogenated benzo [b] thiophenes
• C07D 333/76 - Dibenzothiophenes
• C07F 5/04 - Esters of boric acids
• C08G 61/00 - Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule

Abstract

Provided are: a sulfide solid electrolyte production method which provides, at a high production efficiency, a sulfide solid electrolyte that contains lithium atoms, phosphorus atoms, sulfur atoms, and oxygen atoms, and that has high water resistance, the method including mixing a raw-material-containing substance and a protonic organic solvent containing oxygen atoms to thereby prepare a solution; and a sulfide solid electrolyte that contains lithium atoms, phosphorus atoms, sulfur atoms, and oxygen atoms, and that has a prescribed diffraction peak in an X-ray diffraction measurement using a CuKα ray.

IPC Classes  ?

• H01B 13/00 - Apparatus or processes specially adapted for manufacturing conductors or cables
• C01B 25/14 - Sulfur, selenium, or tellurium compounds of phosphorus
• H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
• H01B 1/10 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances sulfides
• H01M 10/052 - Li-accumulators
• H01M 10/0562 - Solid materials

Abstract

An object of the present invention is to provide a separation system and a separation method that can separate deuterium from a fluid containing light hydrogen and deuterium with high separation efficiency while suppressing equipment deterioration. The present invention provides a separation system including a plurality of separation devices connected in series; each of the plurality of separation devices includes an electrolyte membrane to which an anode catalyst layer and a cathode catalyst layer are provided; a first inflow passage through which a first fluid containing light hydrogen and deuterium flows in, and a first outflow passage through which a second fluid having a lower deuterium content than that of the first fluid flows out are connected to an anode flow passage, a second inflow passage through which a third fluid flows into and a second outflow passage through which a fourth fluid containing light water and heavy water flows out are connected to a cathode flow passage; at least a separation device provided at the most upstream side among the plurality of separation devices is a first separation device into which a gas containing water vapor flows as a third fluid, and from which the third fluid and deuterium that has moved from the anode catalyst layer into the cathode catalyst layer are discharged as the fourth fluid.

IPC Classes  ?

• B01D 59/40 - Separation by electrochemical methods by electrolysis
• B01D 59/42 - Separation by electrochemical methods by electromigrationSeparation by electrochemical methods by electrophoresis
• C25B 1/01 - Products
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 9/70 - Assemblies comprising two or more cells

Abstract

The objective of the present invention is to provide a method for producing a layered composite metal oxide crystal material, which can be utilized as a positive electrode material for a lithium ion secondary battery or the like, in a milder condition, and methods for producing a positive electrode and a lithium ion secondary battery using the above method. The method for producing a layered composite metal oxide crystal material according to the present invention, wherein the layered composite metal oxide crystal material comprises a composite metal oxide represented by the formula: LixMOy wherein M is 1 or 2 or more of transition metals, and a part of the M may be substituted with Al and/or Mg, x is the number of 1 or more and 2 or less, y is the number of 2 or more and 3 or less, a value of x+n is 2×y, wherein n is an average valence of the transition metal M, is characterized in comprising the step of calcining a mixture comprising a monovalent anion salt of lithium, a monovalent anion salt of sodium and/or potassium, and a monovalent anion salt of the transition metal at 150° C. or higher and 400° C. or lower in the presence of a water molecule and oxygen.

IPC Classes  ?

• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• C01G 51/00 - Compounds of cobalt
• C01G 53/00 - Compounds of nickel
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/1391 - Processes of manufacture of electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
• H01M 10/0587 - Construction or manufacture of accumulators having only wound construction elements, i.e. wound positive electrodes, wound negative electrodes and wound separators

Abstract

A slide number estimation apparatus (2000) acquires a slide image (30). The slide image (30) an image of a specimen slide (20) obtained from a tissue piece (10) of a subject. The slide number estimation apparatus (2000) estimates the number of tumor cells included in a region of interest (22) of the specimen slide (20) corresponding to the obtained slide image (30) using the slide image (30). The slide number estimation apparatus (2000) estimates the number of the specimen slides (20) to be obtained from the tissue piece (10) for conducting a predetermined test based on the estimated number of tumor cells.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof: A compound represented by Formula (1), Formula (2), or Formula (3), or a salt thereof, or a solvate thereof: wherein R1, R2, and R3 are the same or different and each represent a hydrazine group, an N-hydroxy-acetylamino group, or an N-hydroxy-formylamino group.

IPC Classes  ?

• C07C 291/10 - Isocyanides
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61P 31/04 - Antibacterial agents
• A61P 31/10 - Antimycotics

Abstract

This prediction device comprises an operational circuit, a storage device, and a communication circuit. The storage device stores correlation information showing correlations between temporal changes in the intensity of each typhoon of a plurality of typhoons and temporal changes in index values of lightning discharges that occurred in the area of influence of each typhoon. The correlation information includes time differences between the time at which the index values of lightning discharges reached a maximum and the times at which the intensity of each typhoon reached a maximum within the period of time from the outbreak of the typhoon to the extinction of the typhoon. The operational circuit acquires lightning data including the position and time of the occurrence of lightning discharges observed during a prescribed period of time, acquires typhoon data including the center position and intensity of an observed typhoon, calculates, on the basis of the lightning data, an index value of lightning discharges that occurred within a prescribed range from the center position, generates lightning discharge information indicating the temporal change in the calculated index value, and calculates a predicted value of the intensity of the typhoon on the basis of the correlation information, lightning discharge information, and the intensity of the typhoon at the latest observation time in the typhoon data.

IPC Classes  ?

• G01W 1/10 - Devices for predicting weather conditions

Abstract

The present invention provides a method for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity, and a kit for quantitatively detecting virus-derived RNA and/or DNA in an environmental sample or a fecal sample with high sensitivity.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6851 - Quantitative amplification
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof: A copper chelating agent that contains at least one compound selected from the group consisting of a compound represented by Formula (1), a compound represented by Formula (2), a compound represented by Formula (3), a compound represented by Formula (4), a salt thereof, and a solvate thereof:

IPC Classes  ?

• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61P 39/04 - Chelating agents

Abstract

Provided is a pharmaceutical composition for treating and/or preventing renal cystic ciliopathy, the composition containing a retinoic acid receptor (RAR) agonist.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/203 - Retinoic acids
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 15/09 - Recombinant DNA-technology