A method of determining a phase correction to apply to a corrective element, comprising the steps of: acquiring low-resolution images; determining pixel intensity values in the low-resolution images; adding pixels one at a time in order of decreasing intensity; back-propagating each image to a pupil plane to obtain an estimate; and measuring a coupling efficiency to phase points to determine an optimum phase.
G02B 27/00 - Optical systems or apparatus not provided for by any of the groups ,
H04B 10/073 - Arrangements for monitoring or testing transmission systemsArrangements for fault measurement of transmission systems using an out-of-service signal
H04B 10/112 - Line-of-sight transmission over an extended range
2.
METHOD FOR CORRECTING MULTIPATH LIGHT PROPAGATION IN STRUCTURED-LIGHT 3D SCANNERS
A method of measuring a 3D shape of an object comprising a target semi-transparent surface, the method comprising the steps of: with a projector, projecting a first light signal having a predetermined pattern and a predetermined frequency from at least one projector column towards at least one location on a scene; with an image capture device, receiving a second light signal from the at least one location of the scene at an image capture device pixel; measuring an intensity signal received at the image capture device pixel; with the measured intensity signal, generating a correspondence map between the at least one projector column illuminating the at least one location of the scene and the image capture device pixel with coordinates receiving the light signal from the at least one location of the scene; and with the correspondence map, determining 3D coordinates of the at least one location of the scene.
G01B 11/25 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures by projecting a pattern, e.g. moiré fringes, on the object
3.
SCALABLE TWO-DIMENSIONAL OPTICAL PHASED ARRAYS WITH REDUCED SIDE LOBES
An emission to free space of a beam with suppressed sidelobes includes providing light to optical antennas separated by a set of spacings substantially larger than a wavelength of light and forming a two-dimensional optical phased array. Phases of light emitted by the optical antennas are distributed uniformly with equalized weights within a full range in substantially all directions of a far-field distribution except a direction of a single beam characterized by an intensity distribution that comprises a central lobe with substantially suppressed sidelobes. The suppression of the sidelobes is at least 10 decibels compared to the central lobe.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles non-covalently interacting with at least a portion of a polymer material via π-π bonding, hydrogen bonding, electrostatic interactions stronger than van der Waals interactions, or any combination thereof. The piezoelectric particles may be dispersed in the polymer material and remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further including a polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
A method of manufacturing a component for use in an aircraft, includes obtaining a composite panel of the aircraft and applying an ink to the panel to provide a coated panel. The ink comprises a metal compound, an organic amine, and a polymeric binder. The coated panel is subjected to sintering to yield the component.
B05D 5/12 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain a coating with specific electrical properties
B05D 1/02 - Processes for applying liquids or other fluent materials performed by spraying
B05D 3/02 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
B05D 3/06 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
B05D 3/14 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by electrical means
B64C 1/12 - Construction or attachment of skin panels
A method and apparatus for inscribing a Bragg grating in the core of an optical waveguide. Electromagnetic radiation at a chosen wavelength passes through a diffractive optical element optimized for the wavelength such that a beam is generated on the waveguide having an interference pattern so as to form a Bragg grating in the core of the optical waveguide, the beam being sufficiently intense to cause a permanent (Type II) change in the index of refraction in the core in the form of at least one elongated micropore. The Bragg grating period can be selected to promote coupling of guided light into a radiation mode for detection by a detector to form a spectrometer. The Bragg grating is characterized by a scattering loss less than 10−5 dB per grating period at the Bragg resonance but outcoupling efficiency at visible wavelengths of 0.03% per grating period.
HIS MAJESTY THE KING IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCE (Canada)
Inventor
Orth, Antony
Stewart, Terrence
Picard, Michel
Drouin, Marc-Antoine
Theberge, Francis
Abstract
A target located method and apparatus for the detection of lasers directed at the target using neuromorphic cameras which improve the detection by use of defocus.
HIS MAJESTY THE KING IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCE (Canada)
Inventor
Hu, Hang
Ooi, Hsu Kiang
Hu, Anguang
Abstract
According to the invention an apparatus is provided for encoding electronic spectra comprising a unit for generating eigenfunctions of quantum angular momenta to transform the Coulomb operator of electronic spectra into an isospectral diagonal form and a un it for decomposing said isospectral diagonal form into atomic orbital angular momentum blocks.
G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
G16C 20/70 - Machine learning, data mining or chemometrics
10.
METHODS AND SYSTEM FOR CHARACTERIZING AND CALIBRATING A WEARABLE HELMET-MOUNTED DIGITAL VISUAL AUGMENTATION DEVICE WITH AN AR/VR DISPLAY
A method for characterizing and calibrating a helmet-mounted digital visual augmentation device for a user, wherein the method comprises: with cameras mounted on the helmet, acquiring stereo images of a calibration target; calibrating a position of the user's eyes; with a projection system, projecting structured-light patterns associated with the target on an AR/VR display; acquiring a 3D model of the AR/VR display and obtaining a shape of the AR/VR display; mapping between AR/VR display pixel coordinate and the position in 3D on the calibration target in front of the user's eyes where the pixel is perceived by the user; encoding deviations of the projection system based on the mapping, wherein the 3D model of the AR/VR display is in a same reference frame as the cameras mounted on the helmet; using at least one machine learning model to correct deviations between an image of the target as seen from a point of view of the user's eyes and an image of the target captured by the cameras; and generating a digital twin of the digital visual augmentation device.
An active die comprising a tubular housing, a piston disposed in an interior of the housing, a piston stop coupled with the housing and a spring device proximal a rearward end of the housing. The spring device comprises a spring washer stack with a plurality of disc spring washers. The piston comprises a cylindrical piston body with a piston crown, and the piston stop comprises a piston stop die surface adjacent and about the piston crown. The piston crown and the piston stop die surface together define a die cavity. The piston is responsive to force applied at the piston crown to compress the spring device to increase a variable depth of the die cavity and to increase a variable counterforce at the piston crown. The active die and method are useful to prevent cracking of a mechanical joint button caused by joining low ductility materials during self-piercing riveting.
According to the invention a method and system are provided for one public key signature and encryption using butterfly key expansion by employing Kyber and Dilithium to support unlinkability and unforgeablity against malicious registration and certificate authorities, alone or in concert.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
According to the invention a transistor is provided. This transistor is formed using an electrolyte slat and is suitable in uses especially, requiring a printable, wearable and/or flexible solution compatible with low silver migration in transistor electrodes.
An exobrake is an externally applied apparatus to reinforce a robotic arm to improve a load capacity, or control, thereof. It includes a brake having a rotary end and a stator end, and mounting hardware for securing these ends the robotic arm to straddle a single actuated revolute joint of the robotic arm between the rotary and stator ends. By aligning the rotary end with the axis of the revolute joint, the exobrake can operate to minimally impact the robotic arm's mobility when the brake is released, and to provide a higher stiffness at the joint when the brakes are applied. The robotic arm is thereby enabled to perform tasks requiring greater loads, especially those that are developed by the end effector or an environment, as opposed to the actuators of the robotic arm.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
The present document describes a pharmaceutical composition comprising a) a lipid nanoparticle operable to encapsulate a therapeutic agent, comprising a core and an external surface, said therapeutic agent being encapsulated within said core; said lipid nanoparticle having a size of said lipid nanoparticle of from about 30 to about 80 nm, or a pegylated lipid comprising a distearoyl-rac-glycerol (DSG)-PEG and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(DSPE)-PEG-DBCO; or a combination of: a size of from about 30 to about 80 nm and a pegylated lipid comprising a DSG-PEG and DSPE-PEG-DBCO; and b) an antibody or antigen-binding fragment thereof operable to transmigrate the blood-brain barrier (BBB), wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDR1, CDR2 and CDR3), operably linked to said external surface of said lipid nanoparticle.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A method for metering a small volume of liquid is provided that leverages a dynamic redistribution provided by surface tension. A sample is made to over fill a metering cup, and occupy part of a surrounding overflow chamber, while providing a free surface above the metering cup and a rim surrounding the cup. Then retraction of the overflow volume to a critical point causes redistribution of the sample and a cleaving of the sample into a metered volume within the cup, and an overflow volume that is extracted.
The present invention concerns new strains of cyanogenic bacteria, and more particularly alkali-tolerant Pseudomonas bacteria, that are useful to gold mining activities. These bacteria are useful to leach gold from any source including ores, concentrates or waste material. They have the ability to effectively produce cyanide at alkaline pH.
An extrudable ceramic composition comprises piezoelectric ceramic particles and carbon nanomaterial particles suspended in a carrier medium. A piezoelectric ceramic material is produced by curing the composition. The carbon nanomaterials are used as additives to extrudable ceramic compositions (e.g., piezoelectric compositions such as PZT/polymer composites, PZT/sol-gel composites, PZT emulsion pastes and the like). The addition of carbon nanomaterials imparts both beneficial rheological properties (shear thinning) and improved piezoelectric performance to the ceramic material.
C04B 35/491 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates containing also titanium oxide or titanates based on lead zirconates and lead titanates
B33Y 70/00 - Materials specially adapted for additive manufacturing
An extrudable composition includes: an aqueous phase comprising acidic water and piezoelectric ceramic particles suspended in the water; and, an organic phase having an organic solvent, a curable polymer precursor or both an organic solvent and a curable polymer precursor. The composition is 3-D printable to form a self-supporting structure and may be infiltrated with an organic polymer material or cured so that the curable polymer precursor forms an organic polymer material thereby forming a piezoelectric composite having piezoelectric ceramic particles in a co-continuous phase.
C08J 9/28 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
A photoresin composition for photopatterning in an oxygen-containing environment has a viscosity of about 300 cP or higher and contains: a reactive monomer with no hydrogen atoms having a bond-dissociation energy of less than about 410 kJ/mol, the hydrogen atoms; a non-amine reducing agent; and, a Norrish Type II photo-initiator. A volumetric additive manufacturing (VAM) process involves: immersing a solid base object in a liquid photoresin composition containing a photo-initiator and a multifunctional material; removing the solid base object with a film coating thereon from the liquid photoresin composition; and, selectively irradiating the composition at the surface of the object with patterned light to initiate covalent grafting or adhesion of the multifunctional material to the surface of the object to pattern only a portion of the surface of the object, where the portion of the surface of the object corresponds to the selectively irradiated surface of the object.
C09D 11/101 - Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
B33Y 50/02 - Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
B33Y 80/00 - Products made by additive manufacturing
C08L 33/08 - Homopolymers or copolymers of acrylic acid esters
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
Highly directional off-chip couplers comprise a periodic or quasi-periodic plurality of diffractive elements covered by a material with a high refractive index such that radiation is enabled toward the upper cladding and frustrated toward the substrate. The geometry of the diffractive elements is precisely chosen to control the radiated field profile. Thus, the device can be used as an ultra-efficient surface grating for coupling light between the chip and an optical fiber or photodetector, as an optical antenna arranged in a phased array configuration, or as an ultra-low-loss chip interconnecting system.
Volumetric Additive Manufacturing allows for the rapid printing of objects by transmitting images into a reservoir holding resin, using wavelengths of light associated with a photocuring characteristic of the resin. Feedback based control can be enabled through the use of optical scattering tomography based imaging of the object during the printing process. Through capturing a set of images representing the scattering of a non-curing light, an isosurface representing the object during printing can be generated. The differences between the isosurface and the expected shape of the object can be used as an input into a control process or they can be displayed to an operator so that printing can be terminated when the printing of the object is complete.
The present disclosure relates generally to compounds, compositions, antibodies, and methods for raising and utilising an immune response in a subject, comprising administering to a subject an isolated or synthesised Pseudomonas aeruginosa glycan, optionally linked to a carrier protein in the form of a glycoconjugate. Further provided is an antibody that selectively binds a Pseudomonas aeruginosa glycan or glycoconjugate as described in this disclosure.
Described herein are BBB-transporting fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating various CNS diseases and conditions, e.g., any mucopolysaccharidosis type with CNS manifestations.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
Disclosed are devices with dynamic optical properties suitable for use as security or authentication devices, for example for documents or items of importance or value, in order to help prevent counterfeit of the same. Such devices, at least in selected embodiments, enable observation of dynamic changes or moving entities within the device by collective or enhanced imaging of the dynamic changes or moveable entities, the motion or position of which may otherwise be difficult to observe, or indiscernible to, the naked eye.
Described herein are ARSB fusion proteins, polynucleotides encoding the fusion proteins and mammalian cells genetically modified to express and secrete the fusion proteins, as well as compositions, implantable devices and device preparations comprising the fusion proteins or genetically modified cells secreting the fusion proteins, and methods of making and using the same for treating MPS-6.
A label for determining a level of a substance in a container, the label comprising: a substrate configured to conform to the container, the substrate having: a first section supporting a light emitter configured to emit light into the container; and a second section supporting a light detector configured to detect the emitted light; and a processor connected to the detector, the processor configured to determine the level of the substance based on the detected light.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a polymer material comprising at least one thermoplastic polymer, at least one polymer precursor, or any combination thereof, and a plurality of piezoelectric particles dispersed in at least a portion of the polymer material. The piezoelectric particles may interact non-covalently with at least a portion of the polymer material, be covalently bonded to at least a portion of the polymer material, and/or be reactive with at least a portion of the polymer material. The compositions may be extrudable and formable into a self-standing three-dimensional structure upon being extruded. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B29K 23/00 - Use of polyalkenes as moulding material
B29K 105/00 - Condition, form or state of moulded material
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C08K 9/04 - Ingredients treated with organic substances
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
29.
RESOURCE EFFICIENT QUANTUM KERNEL WITH ITERATIVE APPENDING FOR SUPPORT VECTOR MACHINES
A quantum logic circuit comprising: a plurality of quantum logic gates configured in a nested structure comprising layers; wherein each of the layers operates on a number of qubits to encode F features from at least one data point, wherein the number of qubits in a preceding layer is higher than the number of qubits in a subsequent layer, and wherein the F features are coherently aggregated in each subsequent layer without measurement thereby reducing the number of qubits required to encode the F features for processing.
Examples are disclosed herein relating to detecting a change in a substrate. A system can include a transducer that can be frequency matched to a substrate and to provide an electrical signal that can characterize a reflected sound wave by the substrate. The system can include an acoustic wave analysis system to detect a change in a physical characteristic of the substrate.
The present document describes antibodies or antigen-binding fragments that bind specifically to a target antigen, wherein the antibodies or antigen-binding fragments comprise complementarity determining regions (CDR1, CDR2 and CDR3) and an added O-glycosylation sequon glycosylated with an O-glycan having the general formula (I): wherein R1 is an initial N-acetylgalactosamine (GalNAc); n=1, or 2; R2 are each independently absent, galactose (Gal), GalNAc, N-Acetylglucosamine (GlcNAc), or a sialic acid; R3 are each independently absent, Gal or a sialic acid; and R4 are each independently absent or a sialic acid. Also described are compounds comprising the antibodies or antigen-binding fragments comprising a functional moiety operably linked to said O-glycan, compositions comprising the same, and methods of preparing such compounds.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
32.
PROCESS FOR PURIFYING SEMICONDUCTING SINGLE-WALLED CARBON NANOTUBES
A process for purifying semi-conducting single-walled carbon nanotubes (sc-SWCNTs) provides electronic grade materials with sc-SWCNT purity in excess of 99.99%. An initial dispersion containing sc-SWCNTs and metallic SWCNTs (m-SWCNTs) dispersed in a non-polar organic liquid medium is exposed to a fiber-like adsorption medium. The fiber-like adsorption medium preferentially adsorbs m-SWCNTs over sc-SWCNTs from the initial dispersion. A purified dispersion is collected after exposure of the initial dispersion to the fiber-like adsorption medium. In the purified dispersion a weight ratio of m-SWCNTs to sc-SWCNTs is smaller than a weight ratio of m-SWCNTs to sc-SWCNTs in the initial dispersion.
C01B 32/174 - DerivatisationSolubilisationDispersion in solvents
H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
33.
TRICKLE-BED SCRUBBER AND SCRUBBING PROCESS WITH WOODCHIP PACKED BED
A scrubbing medium, such as cooking oil, is trickle flowed through a packing material that includes woodchips. Gas, such as from a gasifier, is flowed through the packing material and the scrubbing medium to scrub the gas of tar and particulates. The gas may further flow through a polishing material, such as charcoal. The woodchips include a mixture of coarse and fine woodchips with at least about 25% fine woodchips. A flow of scrubbed gas with reduced tar and particulates in outputted.
A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.
A composition comprising a mixture of two or more stereoisomers of a synthetic charged isoprenoid glycolipid of Formula (I), or a pharmaceutically acceptable salt thereof, in which n is 0 or 1, R and R′ are independently hydrogen or hydroxyl, each Y is independently hydrogen or a sulfate group, and wherein at least one Y is a sulfate group, and less than 25% of the synthetic charged isoprenoid glycolipid molecules in the mixture comprise an archaeol moiety of the configuration (R)-2,3-bis(((3R,7R,11R)-3,7,11,15-tetramethylhexadecyl)oxy) propan-1-ol. Further provided are archaeosomes and immunogenic compositions comprising the composition, use of the composition as an adjuvant or immunostimulant, and processes for synthesizing the composition.
A composition comprising a mixture of two or more stereoisomers of a synthetic charged isoprenoid glycolipid of Formula (I), or a pharmaceutically acceptable salt thereof, in which n is 0 or 1, R and R′ are independently hydrogen or hydroxyl, each Y is independently hydrogen or a sulfate group, and wherein at least one Y is a sulfate group, and less than 25% of the synthetic charged isoprenoid glycolipid molecules in the mixture comprise an archaeol moiety of the configuration (R)-2,3-bis(((3R,7R,11R)-3,7,11,15-tetramethylhexadecyl)oxy) propan-1-ol. Further provided are archaeosomes and immunogenic compositions comprising the composition, use of the composition as an adjuvant or immunostimulant, and processes for synthesizing the composition.
C07H 15/06 - Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of a saccharide radical being a hydroxyalkyl group esterified by a fatty acid
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
C07C 41/09 - Preparation of ethers by dehydration of compounds containing hydroxy groups
A coherent feed forward quantum neural network comprising: a first layer for encoding of input data onto at least one qubit; a second layer comprising a network of controlled parameterized rotation gates and uncontrolled parameterized bias gates; an output layer, wherein a measurement is performed on the final qubit or final set of qubits; and whereby the measurement is only performed once within the coherent feed forward quantum neural network in the output layer.
An apparatus is provided that includes an infrasound microphone for positioning in a soundscape containing turbulence such as may be caused by an aircraft within a radius of the microphone. The apparatus also includes a processor configured to receive an input waveform from the microphone and to perform a signature analysis on the input waveform. The processor is configured to configured to isolate features from the waveform. The isolated features can represent the turbulence. The apparatus may include an output device, such as an aircraft navigation system which can be controlled to update flight paths of other aircraft, based on the isolated features. Various other apparatuses, systems and methods are proposed.
The disclosure relates to methods for diagnosing, detecting or screening for COVID-19 in a subject. The method comprises measuring the concentration of at least two sphingolipids in a blood sample. The sphingolipids are selected from Cer(d18:1/16:0), Cer(d18:1/26:0), 1-O-nervonoyl-Cer(d18:1/18:2), HexCer(d18:1/22:0), Cer(d18:1/18:0) and PE-Cer(d18:1/24:0). The method further comprises determining a ratio of the concentration of the at least two sphingolipids and comparing the ratio with a reference value, wherein a differential between the ratio and the reference value is indicative that the subject has or likely has COVID-19. Also provided is a kit for use with the method disclosed herein.
Here is disclosed isolated or purified monoclonal antibodies, or an antigen-binding fragments thereof, which binds to human CD3, and which comprises: a CDRH1 amino acid sequence of SEQ ID NO: 150, a CDRH2 amino acid sequence of SEQ ID NO: 151, a CDRH3 amino acid sequence of SEQ ID NO: 152, a CDRL1 amino acid sequence of SEQ ID NO: 153, a CDRL2 amino acid sequence of SEQ ID NO: 154, and a CDRL3 amino acid sequence of SEQ ID NO: 155. Also provided are recombinant polypeptides comprising said monoclonal antibody, or an antigen-binding fragment thereof, such as multivalent antibodies, including bispecific T-cell engagers. Also described are chimeric antigen receptors (CARs) for CAR-T therapy comprising any one of the monoclonal antibodies, or antigen-binding fragments thereof. Nucleic acids encoding the aforementioned antibodies, fragments, and polypeptides are also disclosed, along with therapeutic applications in the treatment of and autoinflammatory disease or cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
40.
METHOD AND SYSTEM FOR OBJECT DETECTION AND AVOIDANCE FOR AN AUTONOMOUS VEHICLE
A method and system for object detection and avoidance for an autonomous vehicle is provided. The system comprises a plurality of directional antennas, at least one multi-channel transceiver and a controller. The controller is programmed with computer-executable instructions for detecting, a plurality of radio echo signals from one or more objects, estimating maneuver performance limitations of the autonomous vehicle based on the radio echo signals, and generating at least one collision avoidance maneuver for the at least one autonomous vehicle based on the plurality of maneuver performance limitations and collision risk logic.
A modulation method comprising steps of: a) generating a first signal having a first train of short pulses having a first frequency, and a second signal having a second train of short pulses having a second frequency, wherein each of the signals are associated with a negative or positive sign; b) maintaining a narrow frequency difference between the frequencies; c) imposing chirped modulation on each of the signals to achieve a desired spectral resolution, such that each signal is associated with a chirp having a first sign and a second sign; and d) switching between the signs for each signal over a frequency range, and detecting for each frequency of said frequency range, a spectral response resulting from a transfer of said modulation between the signals wherein the chirp sign of each of the signals is different, thereby obtaining hyperspectral data of said spectral response over said frequency range.
A method for creating arrays of quantum dots, the method comprising the steps of: providing a semiconductor comprising a quantum well, subsurface regions of photosensitive dopants and a plurality of conducting gates deposited on a surface of the semiconductor; generating light from a source; directing the light onto a transmission diffractive optical element to generate a periodic interference pattern; creating an elongated quantum dot or a plurality of elongated quantum dots inside the semiconductor by applying voltages to a first plurality of the conducting gates or by means of mesa etching; irradiating the semiconductor with the interference pattern generated by the transmission diffractive optical element to periodically change the charge state of the photosensitive dopants, thereby inducing a periodic electrostatic potential near the plurality of elongated quantum dots and thus partitioning the elongated quantum dots into smaller quantum dots defined by the light-induced periodic electrostatic potential.
A method is provided for preparing a semiconductor wafer for fabricating a semiconductor heterostructure device, or for fabricating the semiconductor heterostructure device on the semiconductor wafer. The method comprises dry etching at least one epitaxial layer to produce a dry-etched semiconductor wafer defining a mesa structure. Then, an etchant gas is flowed through a reaction chamber to remove material from sidewalls of the mesa structure and thereby produce a cleaned semiconductor wafer in which the sidewalls of the mesa structure undercut a mask layer and have reduced surface defects in comparison to the sidewalls of the mesa structure of the dry-etched semiconductor wafer. Then, an overgrowth layer is grown on the sidewalls of the mesa structure of the cleaned semiconductor wafer.
Provided is an additive for a stretchable and/or flexible electrically conductive ink, the additive comprising: small liquid molecules with a high dielectric constant; wherein the additive improves electrical conductivity of the stretchable and/or flexible electrically conductive ink, and wherein the stretchable and/or flexible electrically conductive ink comprises a binder and electrically conductive particles.
A computer-implemented method for communications network maintenance, the method comprising the steps of: acquiring raw data associated with the communications network a plurality of datasets; preprocessing the raw data by converting the raw data into a predefined data format to form a plurality of datasets and correcting any inconsistencies in the plurality of datasets; training a neural network with the plurality of datasets to detect at least one of an anomalous event and a network anomaly event, and localizing the communications network anomaly event to infer at least one root cause for the communications network anomaly event; and creating and executing a self-maintenance scheme to mitigate against effects of the at least one of the anomalous event and the communications network anomaly event.
Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component present therein. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles dispersed in at least a portion of a polymer matrix comprising first polymer material and a sacrificial material, the sacrificial material being removable from the polymer matrix to define a plurality of pores in the polymer matrix. The piezoelectric particles may remain substantially non-agglomerated when combined with the polymer matrix. The sacrificial material may comprise a second polymer material. The compositions may define a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes may comprise forming a printed part by depositing the compositions layer-by-layer and introducing porosity therein.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
B29C 64/165 - Processes of additive manufacturing using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
C08L 53/02 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
C08L 67/04 - Polyesters derived from hydroxy carboxylic acids, e.g. lactones
C09D 4/06 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
There is provided a method for depositing a TiO2—Cr2O3 ceramic coating on a substrate. The method includes mixing a powder of sprayable nanostructured titanium(IV) oxide (n-TiO2) and a powder of chromium(III) oxide (Cr2O3), thereby obtaining a n-TiO2—Cr2O3 powder blend. The method also includes thermal spraying particles of the n-TiO2—Cr2O3 powder blend on the substrate at an in-flight particle temperature of or greater than 2350° C. and a particle in-flight velocity of or greater than 350 m/s, thereby obtaining a coated substrate.
C04B 35/46 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on titanium oxides or titanates
C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C23C 4/12 - Coating by spraying the coating material in the molten state, e.g. by flame, plasma or electric discharge characterised by the method of spraying
C23C 24/04 - Impact or kinetic deposition of particles
F16K 5/06 - Taps or cocks comprising only cut-off apparatus having at least one of the sealing faces shaped as a more or less complete surface of a solid of revolution, the opening and closing movement being predominantly rotary with plugs having spherical surfacesPackings therefor
F16K 25/00 - Details relating to contact between valve members and seats
F16K 25/04 - Arrangements for preventing erosion, not otherwise provided for
49.
METHOD AND SYSTEM FOR TARGET DETECTION AND CLASSIFICATION TO AID DRONE DEFENCE SYSTEMS
A model-based artificial intelligence (Al) system and method that applies trained decision- making on extracted features for target classification, including at least one sensor for detecting a point target, an interactive multiple model (IMM) filter for extracting features related to motion kinematics of the point target, and a classifier for applying trained decision-making on the extracted features to determine classification of the point target
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/40 - Extraction of image or video features
A graphical user interface is generated with flight data of an unmanned aerial vehicle that is controllable by a surface-based pilot with a remote control. The graphical user interface is outputted to an observer computing device that is remote from the surface-based pilot. The graphical user interface provides the flight data to an observer at the observer computing device. Flight data may include video, flight parameters, geographic location, and similar data to facilitate a task carried out by the pilot and the remote observer, such as the inspection of infrastructure.
Flight data of an unmanned aerial vehicle or UAV is determined while the unmanned aerial vehicle is under control of a surface-based pilot. An overlay that describes the flight data is generated. The overlay may present operational data, such as altitude and speed; video, such as captured from a camera at the UAV; or a combination of such. The overlay combined with a real view of the unmanned aerial vehicle is displayed to the surface-based pilot.
Provided are methods, expression systems, kits, and vectors for constitutive and/or cumate-inducible expression of a gene of interest in CHO cells. The expression systems and methods described herein employ CHO cells that are stably transfected with a nucleic acid molecule encoding a reverse cumate transactivator (rcTA), the expression of which is regulated by a cymene repressor (CymR). for constitutive and/or cumate-inducible expression of a gene of interest.
Flight data of an unmanned aerial vehicle or UAV is determined while the unmanned aerial vehicle is under control of a remote pilot. An overlay that describes the flight data is generated. Further, an alert indication is generated on the condition of deviation of the UAV from center of view.
The present application relates biodegradable polymer material and electrochemical devices. More specifically, the present application relates to biodegradable polymer materials, their use in electrochemical devices and a method for preparing the same. More specifically, the biodegradable polymer material of the present application relates to comprises a polyester backbone; and redox active functionalities grafted to the polyester backbone, where the redox active functionalities may be selected from a stabilized radical species, a viologen species, a naphthalene diimide, and a quinone species.
A system and a method of detecting an introduction event of a substance into a water distribution system (WDS) are provided. The method comprises: receiving, by a processor, emergency call data including location data and timing data of emergency calls; generating, by the processor, an input data representation of the location data and the timing data of emergency calls; providing, by the processor, the input data representation to an event detection model trained to detect the introduction event using training data representations generated by simulating dispersion of the substance within the WDS; and generating, by the processor, an event detection output indicating an occurrence of the detected introduction event.
Compounds, e.g., radioimmunoconjuguates including a chelating moiety or a metal complex thereof, a linker, and an EGFRVIII targeting moiety. Pharmaceutical compositions of such compounds and methods of treatment for conditions. e.g., cancer, using such compounds or pharmaceutical compositions.
C07D 257/02 - Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
57.
HUMANIZED ANTI-EGFR VIII ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS THEREOF
Antigen-binding agents such as humanized antibodies or antigen-binding fragments thereof, that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRVIII-specific humanized antibodies or antigen-binding fragments thereof may be used for the treatment of cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
A61K 39/00 - Medicinal preparations containing antigens or antibodies
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A rail assembly for use with a bogie wheel includes two rail segments having mating end segments abutting against each other, and joined by a connecting bolt that traverse the mating end segments. A bogie for use with a rail includes a support frame, a chassis movably attached to the support frame, and an elastomeric bearing disposed between and in bearing engagement with the support frame and the chassis, to limit movement of the chassis relative to the support frame. A bogie wheel includes a central hub adapted for direct mounting to a bogie chassis, a tread, and a bearing assembly permitting rotation of the tread relative to the hub. An inflatable seal assembly for sealing between a first member and a second member includes an inflatable bladder, a membrane attached to the first member, and a tension spring attached to the membrane to bias the membrane against the bladder.
A system and method are provided for optical beamforming and interferometry using digital source modulation. In one aspect, a digitally-modulated calibration signal is included in the optical target source, for use by receiving mirrors and equipment to continuously lock onto, track, and remove atmospheric and instrumental temporal distortion effects. By using this digitally-modulated calibration signal throughout the optical signal chain any variations that both it and the science/pay load signal undergo can be removed, leading to lower cost optical mirrors and optical interferometers, as well as allowing for larger optical apertures
A method of calibrating measurement of aerosol absorption is provided. A pump beam capable of operating with at least two wavelengths is directed to overlap with a probe beam in a gas in a sample region, wherein the first pump beam wavelength overlaps with an absorption line of a gaseous species of the gas and the second pump beam wavelength does not. Resulting first and second photothermal signals are detected. A light absorption value of the gaseous species is determined based on the first photothermal signal and the second photothermal signal. The light absorption value is stored, for recalling in calibrating the measurement of aerosol absorption. A method of measuring aerosol absorption and a self-calibrating apparatus for measurement of aerosol absorption are also provided.
A method and apparatus are set forth for volumetric additive manufacturing (VAM) wherein light rays that are used to determine tomographic projections are modelled using ray tracing, in order to account for projector non-telecentricity and etendue in all three dimensions. The path of rays from each light source (e.g. pixel) are computed as they propagate through the VAM system. Optical effects such as refraction, transmission loss, absorption, etendue, and non-telecentricity are intrinsically accounted for via ray tracing. Using these rays, the required dose to solidify the photosensitive resin is computed.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
B29D 11/00 - Producing optical elements, e.g. lenses or prisms
A coupler for coupling an RF connector to an ultrasound sensing element. The coupler includes a conductive coupler body with a first end and a second end. The first end includes a pad retaining recess with a compressible conductive pad positioned in and protruding from the pad retaining recess. The second end either includes an opening for receiving a male pin of a radio frequency (RF) connector or is shaped to be press-fitted into the female pin opening of an RF connector, to conductively connect the pin with the coupler body. A sensor connector is also disclosed.
H01R 24/54 - Intermediate parts, e.g. adapters, splitters or elbows
G01H 11/08 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by detecting changes in electric or magnetic properties by electric means using piezoelectric devices
A semiconductor optical laser cavity with suppressed mode-hopping having facet optical coatings with optimized spectral properties favoring laser emission at a desired wavelength range, and suppressing mode-hopping towards undesired emission wavelengths.
Provided herein are methods of producing virus from a culture of host cells. The methods include providing a culture of host cells which has been infected by the virus; contacting the host cells with a first buffer comprising a detergent and incubating the host cells in the presence of the first buffer for a first period of time thereby producing a cell lysate; contacting the cell lysate with a second buffer comprising an endonuclease for a second period of time to degrade the host cell nucleic acids; and collecting the virus.
The presently disclosed methods provide for preparing a stable hydrophobic self-assembled monolayer (SAM) coating, that includes preparing a SAM solution by combining a SAM compound with an initial solvent and an additional solvent and mixing, in a sealed container, the SAM solution at a first fixed temperature at a constant rotational speed for a first fixed time interval. The SAM coating is then prepared by treating a substrate to achieve pristine state, and heating the substrate at a second fixed temperature for a second fixed time interval. Then within a sealed container, immersing the substrate in the SAM solution for a third fixed time interval. Following the completion of the third fixed time interval, the substrate is removed from the sealed container and treated with the initial solvent and the additional solvent to remove excess SAM material, and heated at a third fixed temperature.
B05D 7/14 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
B05D 3/00 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
A ridge fluidic device comprising: a substrate and a fluidic component comprising at least one fluidic channel, wherein the at least one fluidic channel is adapted to conduct a fluid and retain the fluid within the at least one fluidic channel: wherein the at least one fluidic channel comprises porous material having a hydrophilic surface; and wherein the at least one fluidic channel is formed on the substrate via a deposition process.
Described are various embodiments of a refractory lance assembly and a composite refractory lance. In one embodiment, a refractory lance assembly is provided that comprises: an immersion tube having an immersion tip immersible within a melt and an extension tube coupled at an opposed end thereof to form a longitudinally extended composite tube therewith defining an optical path therein, wherein said longitudinally extended composite tube is injectable, in use. with an inert gas to form and probe an immersed melt surface. The assembly further comprises a shroud longitudinally encasing the composite tube and injectable with inert gas to mitigate fluid contamination of the composite tube and immersed melt surface.
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (Canada)
Inventor
Kulka, Marianna
Semenchenko, Valentyna
Sim, Valerie
Willows, Steven Derald
Woodside, Micheal
Abstract
The present document describes IgE antibodies that bind specifically to prion protein (PrP), which may provide lower levels of degranulation from an activated mast cell bound with said IgE antibodies compared to an activated mast cell bound with an HE1 control IgE monoclonal antibody. This work shows that recombinant anti-PrP IgEs can activate LAD2 cells to release enzymes that can degrade PrP, suggesting that IgEs may be useful in targeting diseases that involve protein aggregation.
C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
The present application provides two dimensional benzo[4,5]imidazo[2,1-a]isoindole incorporated non-fullerene electron acceptors having the structure of Formula I (I), and processes for the synthesis and manufacture thereof. Also provided are semiconductor materials, polymers, oligomers, films and membranes incorporating the non-fullerene acceptor of Formula (I), and the optoelectronic devices made therefrom.
The present application provides two dimensional benzo[4,5]imidazo[2,1-a]isoindole incorporated non-fullerene electron acceptors having the structure of Formula I (I), and processes for the synthesis and manufacture thereof. Also provided are semiconductor materials, polymers, oligomers, films and membranes incorporating the non-fullerene acceptor of Formula (I), and the optoelectronic devices made therefrom.
C07D 495/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
H10K 30/30 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising bulk heterojunctions, e.g. interpenetrating networks of donor and acceptor material domains
H10K 85/60 - Organic compounds having low molecular weight
A contaminant sensor for use in an air flow path of a fuel cell system upstream of a fuel cell, the fuel cell including a cell catalyst layer having a catalyst layer composition. The sensor may include a detection electrode including a sensing element having a composition that is the same as the catalyst layer composition, such that the output of the sensor can correspond to the response of the fuel cell. The output of the sensor may be processed to detect a contamination event without applying a calibration factor to the output. When contaminants are detected or detected at a quantity or rate above a predetermined threshold, an air filter may be replaced or an alert may be generated to warn a user to replace an air filter. The sensor may be manufactured by using a sample of the catalyst, without the composition of the sample being disclosed.
A composition for use in a photo-active device has: a charge transfer network of single walled carbon nanotubes (SWCNT) having at least 95 wt % of semiconducting single walled carbon nanotubes (sc-SWCNT) based on total weight of the SWCNT, the sc-SWCNT containing at least 30 wt % of one chiral type of sc-SWCNT based on total weight of the sc-SWCNT; and, a solution processible electron trapping material of a fullerene compound, the electron trapping material in contact with the charge transfer network of SWCNT. The composition is readily prepared from solution processible components and is highly sensitive in a narrow wavelength band. The composition is particularly useful in photoconductors and phototransistors that operate on the infrared region of the electromagnetic spectrum.
H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
H10K 71/40 - Thermal treatment, e.g. annealing in the presence of a solvent vapour
H10K 85/20 - Carbon compounds, e.g. carbon nanotubes or fullerenes
H10K 101/30 - Highest occupied molecular orbital [HOMO], lowest unoccupied molecular orbital [LUMO] or Fermi energy values
H10K 101/40 - Interrelation of parameters between multiple constituent active layers or sublayers, e.g. HOMO values in adjacent layers
A monolithic non-classical light source employs nanowires that are grown from a silicon-on- insulator fabrication. The nanowires are grown to be substantially horizontal to the plane of the insulator, which allows for them to be coupled to waveguides. A quantum dot within the nanowire can generate the non-classical light in response to being excited through an external stimulus such as a pump light. The non-classical light can be coupled into a waveguide or transmitted through free-space. The monolithic nature of the light source allows for lithographic processes to be used to create much of the structure of the light source before nanowires are epitaxially grown in place.
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
H01S 5/04 - Processes or apparatus for excitation, e.g. pumping
74.
ANTI-MESOTHELIN (MSLN) SINGLE DOMAIN ANTIBODIES AND THERAPEUTIC CONSTRUCTS
The present disclosure provides anti-MSLN single domain antibodies (sdAb), as well as constructs comprising the sdAbs. The constructs include multivalent antibodies comprising any one of the sdAbs, such constructs including bispecific T-cell engagers (BiTEs), bispecific natural killer cell engagers (BiKEs), and trispecific killer cell engagers (TriKEs). Also described are chimeric antigen receptors (CARs) for CAR-T and CAR-NK therapy comprising any one of the aforementioned sdAbs. Uses of these molecules in the treatment of cancers (in particular, solid cancers) are also described.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
A bottom grating semiconductor device, such as a DFB laser, and method of fabricating a bottom grating semiconductor device for increasing Kappa value, comprising overgrowing a planarization layer on a grating layer of the semiconductor device, wherein the grating layer includes a plurality of Bragg gratings, etching back the planarization layer to a desired thickness over the grating layer, and growing an active layer on the etched back planarization layer.
H01L 21/203 - Deposition of semiconductor materials on a substrate, e.g. epitaxial growth using physical deposition, e.g. vacuum deposition, sputtering
H01L 21/304 - Mechanical treatment, e.g. grinding, polishing, cutting
76.
LIPOPROTEIN LIPASE EXPRESSION CONSTRUCTS, VIRAL PARTICLES, AND THERAPEUTIC APPLICATIONS THEREOF
Herein are described recombinant nucleic acid molecules for improved expression of human lipoprotein lipase compared to GlyberaTM. The recombinant nucleic acid molecule comprises a promoter for driving expression of hLPLS447X, and comprising the sequence of any one of SEQ ID NOs: 13 to 16 or a sequence having at least 80% sequence identity thereto; an expression cassette encoding the hLPLS447Xand a polyadenylation signal, and optionally comprising a woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) or a truncated WPRE. The polyadenylation signal may be from human growth hormone. The WPRE or truncated WPRE may be entirely absent. Also described are recombinant AAV viral particles comprising the recombinant nucleic acid, which may be used in therapeutic applications, such as treating plasma lipidemia and/or lipoprotein lipase deficiency. Also described are intramuscular and intravenous administration of AAV8 serotype particles yielding improvements compared to GlyberaTM per unit dose.
Systems and methods relating to the estimation of battery state of health (SOH) and/or battery state of charge (SOC) without the need for lengthy charge-discharge cycles. A testing system uses a machine learning trained estimation model to provide estimates for battery SOH or battery SOC based on battery test results for specific battery characteristics based on battery chemistry. The testing system, once the battery chemistry is entered, automatically applies tests to the battery and calculates values for specific characteristics based on the test results. The values for the specific characteristics are then used by the trained estimation model to estimate battery SOH or battery SOC. The system is based on a data driven approach to estimating battery state of health and/or battery state of charge based on the selection of specific characteristics (or parameters) and correlating values for these characteristics with battery state of health and/or battery state of charge.
The present invention relates, in general, to polypeptides capable of neutralizing SARS-CoV-2 and providing ACE2 enzymatic activity, and uses of these polypeptides for treating disorders related coronaviral infections (COVID-19) and the accompanying acute respiratory distress syndrome (ARDS) and major organ injuries, and methods of making such molecules.
A scalable batteryless power supply is provided for harvesting light energy and powering a load, comprising a light energy harvester; a circuit for periodically sampling an output voltage of the energy harvester and in response generating a reference voltage; and a plurality of cascaded energy storage branches for storing energy from the energy harvester and powering the load, wherein each energy storage branch triggers charging of a downstream energy storage branch provided the voltage thereacross remains above the reference voltage.
H02J 1/00 - Circuit arrangements for dc mains or dc distribution networks
H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the networkCircuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
The present disclosure relates to a material having a three-dimensional shape. In particular, the material has a three-dimensional shape comprising a first phase and a second phase. The first phase comprises a crosslinked polymer and the second phase comprises a second polymer that is present in a concentration gradient within the crosslinked polymer to form an interpenetrating network having a concentration gradient.
C08L 51/08 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
F16F 15/04 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system using elastic means
A technique for centrifugal micro-aliquoting on a centrifugal microfluidic chip having a membrane provided opposite a microwell array, the membrane actuable to effectively enclose microwells, displacing the liquid into adjacent microwells, or away from the array. As meniscus and like effects can be minimized, a more uniform volume may be aliquoted in comparison with structures that rely on an air-interface. As the membrane can be actuated during centrifugation, via a pneumatic blade or slip ring, aliquots can be isolated before centrifugation stops. As the liquid becomes enclosed by the membrane and microwells, they are effectively incapable of cross¬ contamination or fluid exchange, and entrained bubbles can be avoided.
Described herein are antibodies that specifically recognize the SARS-CoV-2 spike (S) polypeptide, compositions comprising said antibodies, uses thereof, and methods employing said antibodies. Each antibody specifically recognizes the S1-RBD domain, S1-NTD domain, or S2 subunit of the SARS-CoV-2 spike polypeptide. Some antibodies are cross-reactive with variants of SARS-CoV-2 and other coronavirus spike polypeptides, such as SARS-CoV S, pangolin CoV S, bat SARS-like CoV S, and civet SARS-CoV S.
HHH), compositions comprising said antibodies, and uses and methods of use thereof. Compositions comprising more than 1 anti-VHH antibody are broadly reactive with VHH proteins providing a reagent for detecting VHHs generally. Methods for the detection of the surface expression of a sdAb domain from Lama glama on a cell, and methods of stimulating or blocking activation, expansion, or both of a chimeric antigen receptor (CAR)-T cell, using the antibody or antigen-binding fragment thereof are also disclosed.
C07K 16/42 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against immunoglobulins (anti-idiotypic antibodies)
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
DPEP-1 binding agents, including antibodies, and pharmaceutical compositions containing the same are described. Also provided are methods for using and manufacturing such binding agents, antibodies and pharmaceutical compositions, as well as methods of their use for treating or preventing a disorder in a human subject in need thereof.
It is provided a metallic textile and a process for producing same, the metallic textile comprising a titanium textile layer having an interlocking dendritic microstructure, a porosity of from 20 to 95 %. The titanium textile layer can have a flexibility sufficient to allow the titanium textile layer to be rolled on itself. The metallic textile can be incorporated in a rolled product and/or used as porous transport layer in an electrolytic cell.
ee of parallel leading edges of two or more wings to provide a blown wing enhancement that permits pitch transition during flight with greater control throughout the transition. The PPLA preferably has at least three substantially parallel wings, and at least four proprotors, each of which proprotors: affixed to a bracing extended between two of the at least three wings. Hover mode and forward flight modes can both have excellent control, allowing for better flight efficiency.
B64C 39/08 - Aircraft not otherwise provided for having multiple wings
B64C 27/26 - Compound rotorcraft, i.e. aircraft using in flight the features of both aeroplane and rotorcraft characterised by provision of fixed wings
SOCIÉTÉ DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES ET GÉNIE S.E.C. (Canada)
NATIONAL RESEARCH COUNCIL OF CANADA (Canada)
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (Canada)
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (Canada)
QUANTUM SILICON INC. (Canada)
Inventor
Pioro-Ladrière, Michel
Foote, Ryan Howard
Wolkow, Robert A.
Pitters, Jason
Coish, William
Fehse, Felix
Abstract
A quantum magnetometer for measuring a magnetic field is provided. A Pauli Spin Blockade (PSB) system having, the at least discrete physical feature with a given spin state tunnel coupled to each of a source and a drain, is provided. The at least discrete physical feature is positioned between the source and the drain. A detector is configured to detect a magnetic field-dependent spin state at one or more of the source lead or the drain lead. An amplifier is configured to amplify the detected magnetic field-dependent transport current in some inventive embodiments.
A permanent magnet (PM) for use in an electric machine including at least one cavity containing a phase change material (PCM) integrated with said PM, the PCM having a phase transition temperature between about 80° C. to about 200° C., and preferably a latent heat of at least 50 KJ/kg, wherein in PM, each cavity is a blind, elongated chamber extending from one side of the PM, having two smaller dimensions and a larger dimension of each cavity is oriented substantially in a same direction, wherein the PM is composed of a hard magnetic phase, a binder phase and PM having an ultimate tensile strength of at least 150 Megapascal (MPa), wherein PM is mounted on a rotor of an electric machine and is formed by cold spray additive manufacturing (CSAM)
B33Y 80/00 - Products made by additive manufacturing
H02K 1/02 - Details of the magnetic circuit characterised by the magnetic material
H02K 15/03 - Processes or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of stator or rotor bodies having permanent magnets
A method for timing aperture synthesis arrays comprising the steps of: (a) coupling a plurality of independent crystal oscillators, each of the plurality of independent crystal oscillators having a unique output frequency; (b) digitally synchronizing the plurality of independent crystal oscillators in phase; (c) combining the unique output frequencies; and (d) obtaining a stable digital reference signal for timing at least one remote radio device of the aperture synthesis array.
The present disclosure relates to a method and system for preparing multimetal alloy nanoparticles (MMA NPs) such as high entropy alloy nanoparticles (HEA NPs). The method comprises: introducing a metal source comprising a plurality of metals into a thermal zone of a plasma torch to obtain a metal vapour comprising the plurality of metals; substantially homogenizing the metal vapour by plasma expansion and turbulence; cooling the metal vapour to co-nucleate and co-condense the MMA NPs; and collecting the MMA NPs. The system comprises a reactor comprising a reaction chamber; a plasma torch; an inlet for introducing a multimetal source to the plasma torch; the reaction chamber configured to substantially homogenize metal vapour by creating one or more of plasma expansion or turbulence; the reactor configured to cool the metal vapor to co-nucleate and co-condense the MMA NPs; and a collecting device.
B22F 9/12 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from gaseous material
Methods and systems for synchronizing at least one remote local oscillator with a central local oscillator, comprising receiving a remote local oscillator signal from at least one remote local oscillator and a master local oscillator signal from the central local oscillator and in response determining a round-trip phase measurement of temporal delay variability of the duplex real-time link between the remote station and central station, measuring frequency vs. time of the remote local oscillator signal relative to the master oscillator, adjusting the measured frequency vs. time according to the round-trip phase measurement to remove effects of temporal delay variability over the duplex real-time link telemetry, digitally filtering the measured frequency to remove variations in frequency on timescales<10× the round-trip delay and that are known not to be intrinsically due to the remote local oscillator, generating a phase increment signal from the filtered measured frequency, receiving and adjusting the local oscillator signal according to the phase increment signal and in response generating a derived digital domain clock signal that tracks the master local oscillator signal and converting the derived digital domain clock signal to an ultra-low phase-noise time domain voltage clock signal.
H03L 7/14 - Details of the phase-locked loop for assuring constant frequency when supply or correction voltages fail
H03L 7/093 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal using special filtering or amplification characteristics in the loop
A wideband resampling channelizer is provided, comprising a plurality of signal processing modules for generating a plurality of output channels that are adjusted for phase and frequency and tagged with an output time stamp in relation to the input data samples, and a control module for controlling the plurality of signal processing modules based on a plurality of configuration parameters such that channelization and resampling operations are combined.
G08C 13/00 - Arrangements for influencing the relationship between signals at input and output, e.g. differentiating, delaying
G01D 5/252 - Selecting one or more conductors or channels from a plurality of conductors or channels, e.g. by closing contacts a combination of conductors or channels
G01V 3/12 - Electric or magnetic prospecting or detectingMeasuring magnetic field characteristics of the earth, e.g. declination or deviation operating with electromagnetic waves
Herein are described isolated or purified anti-Tfr single domain antibodies or antigen-binding fragments thereof, comprising a complementarity determining regions (CDRs) from any one of SEQ ID NOs: 16 to 20. Also described are anti-Tfr single domain antibodies having a CDR1 sequence selected from the group consisting of GSTFSINA (SEQ ID NO:1), TLALEHYA (SEQ ID NO:4), GFTFSRYP (SEQ ID NO:7), GFTFSNYY (SEQ ID NO:10), and GRTFSVYA (SEQ ID NO:13); a CDR2 sequence of IRNGGST (SEQ ID NO:2), VGKDDTTT (SEQ ID NO:5), IDSTGTRT (SEQ ID NO:8), IDTNGLNT (SEQ ID NO:11), and ISSGGTT (SEQ ID NO:14); and a CDR3 sequence of LADLPGDVIA (SEQ ID NO:3), AIGPVSGCNCLLDNSRDYEY (SEQ ID NO:6), GHVGYEL (SEQ ID NO:9), AAEEEKPYHAYWFSTTDSDYDY (SEQ ID NO:12), and NLGDYWTGDYRPSGY (SEQ ID NO:15). Also described are humanized variants and recombinant constructs, such as fusion constructs, along with applications in delivery of cargo molecules across the blood brain barrier (BBB).
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A digital clean-up oscillator and associated method are provided for cleaning jitter from a noisy clock signal, comprising receiving a reference clock oscillator signal and the noisy clock signal to be cleaned: measuring the frequency of the reference clock signal in the time domain of the noisy clock signal: filtering any frequency variations from the measured frequency of the reference clock signal on timescales shorter than a phase change interval Tau_clean over which jitter in the noisy clock signal is to be cleaned; generating a phase increment signal DDS_pinc based on the measured and filtered frequency of the reference clock signal: clocking the phase increment signal DDS_pinc with the reference clock signal for generating an output digital phase ramp signal φ_DDS(t) that tracks the frequency of the noisy clock signal with phase wander removed on timescales less than the phase change interval Tau_clean; and converting the output digital phase ramp signal φ_DDS(t) to an output jitter-cleaned time domain clock signal frequency locked to the noisy clock signal.
H03L 7/093 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal using special filtering or amplification characteristics in the loop
H03L 7/14 - Details of the phase-locked loop for assuring constant frequency when supply or correction voltages fail
A system is provided for coupling light that has been distorted by atmospheric turbulence into an optical data output, comprising a beamlet generator for receiving and focusing distorted wave front beamlets in free space onto an integrated circuit having a photonic adaptive optics system for outputting a single corrected coherent combination of beamlets to the optical data output.
Methods and systems for reducing solar cell degradation are provided. The methods and systems related to frequently applying large reverse bias current-voltage (J-V) sweeps to the cell to reduce the rates of internal degradation of the solar cells. The frequent sweeps serve to detrap charge carriers formed in the cell due to photo-oxidative damage. This detrapping reduces the rate of power conversion efficiency (PCE) degradation throughout the life of the solar cell.
An electrochemical device is disclosed and may include an electrolyte composition disposed between the anode and the cathode and a water vapor barrier which may include a biodegradable material, where the water vapor barrier is disposed to prevent water vapor escaping from the electrochemical device. The water vapor barrier further may include poly lactic acid or a metalized coating. The water vapor barrier further may further include multiple layers and have a water vapor transmission rate (WVTR) less than or equal to 2 wt % over 24 hours. Embodiments of the water vapor barrier may also include a polymeric biodegradable material or a metalized coating disposed onto the biodegradable material. The water vapor barrier may also include multiple layers and may have a water vapor transmission rate (WVTR) less than or equal to 1 mg per cm2 over 24 hours.
The present invention provides a method and system to correctly sample, at a central location, a signal at a second clock frequency from a remote antenna when the signal is at a first clock frequency. The present invention provides an improved method of incoherent clocking to correctly sample a signal from a remote antenna at a clock frequency of a central location, such as a central site of a radio telescope array. The signal contains a “tracer” which is related to the frequency of the remote antenna. The tracer phase is written into a dual-port memory at the first clock frequency and then read from the memory at the second clock frequency. The tracer phase is transferred across digital clock domains using Gray-doe methods so that phase coding errors do not occur.
A system for the online sorting of ore samples based on mineralogy analysis includes a conveyor moving a stream of the ore samples along a conveying path, a LIBS module, a height measuring device, a focus controller and an airflow system. The LIBS module projects a LIBS laser beam along an optical path focused on an analysis spot of dimensions of the order of one or a few mineral components of the ore samples, and collects a returning LIBS light signal. The height measuring device and focus controller collaborate to adjust in real-time the focus of the LIBS laser beam to move the analysis spot perpendicularly to the conveyor according to a height of the ore samples crossing the optical path. The air flow system moves particles away from the optical path. A processing unit performs the mineralogy analysis of the ore sample based on the LIBS light signal.
B07C 5/342 - Sorting according to other particular properties according to optical properties, e.g. colour
B07C 5/02 - Measures preceding sorting, e.g. arranging articles in a stream, orientating
G01N 21/71 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
G01N 21/84 - Systems specially adapted for particular applications
100.
OPTO-ELECTRONIC DETECTION OF MULTI-COPTERS USING PROPELLERS SPECTRAL SIGNATURES
