National Cheng Kung University

Taiwan, Province of China

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A61B 5/00 - Measuring for diagnostic purposes Identification of persons 28
A61K 38/00 - Medicinal preparations containing peptides 14
A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum 14
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1.

METHOD FOR EVALUATING BODY COMPOSITION AND SYSTEM FOR USING THEREOF

      
Application Number 18942902
Status Pending
Filing Date 2024-11-11
First Publication Date 2025-07-03
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Su, Pei-Fang
  • Tsai, Yi-Shan
  • Lai, Yu-Hsuan
  • Liu, Yi-Chia

Abstract

The present invention provides a method for evaluating body composition and a system for using thereof. The method comprises inputting a body composition index and an individual variable to a body composition prediction model so as to produce a body composition evaluation index. The body composition index, comprising a muscle index, a fat index or a comprehensive index, is measured according to a medical image, and the individual variable corresponds to an individual variable of the medical image. The system is configured to obtain the body composition index and the individual variable, and produces the body composition evaluation index accordingly. By using the method and the system, a quantile and a body age evaluation value of a corresponding individual among a normal population can be obtained, and requires only a medical image or a body composition index produced according thereto, which assists judgement of the individual's health status.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons

2.

SINGLE-INDUCTOR MULTIPLE-OUTPUT DC-DC CONVERTER

      
Application Number 18395905
Status Pending
Filing Date 2023-12-26
First Publication Date 2025-06-26
Owner
  • National Cheng Kung University (Taiwan, Province of China)
  • Himax Technologies Limited (Taiwan, Province of China)
Inventor
  • Fan, Ming-Yan
  • Chen, Yi-Fu
  • Chen, Bo-Rui

Abstract

A single-inductor multiple-output DC-DC converter includes a first power switch controlled by a first power switch signal and a second power switch controlled by a second power switch signal, connected in series between a positive supply voltage and a negative supply voltage, and interconnected at an input node; a single inductor with a first end connected to the input node; a plurality of output switches, controlled by corresponding output switch signals, connected in parallel with first ends connected to a second end of the inductor, second ends of the output switches, acting as output nodes, providing corresponding output voltages respectively; and a dual mode charge controller coupled to receive an input voltage at the input node, to receive the output voltages, to receive a state flag, and configured to accordingly generate the first and second power switch signals and the output switch signals.

IPC Classes  ?

  • H02M 1/00 - Details of apparatus for conversion
  • H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load

3.

TRANSFORMER DEVICE AND PLASMA GENERATING APPARATUS CONTAINING THE SAME

      
Application Number 18624205
Status Pending
Filing Date 2024-04-02
First Publication Date 2025-06-26
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Liao, Jiunn-Der
  • Cheng, Ming-Hsien

Abstract

A transformer device comprises: a magnetic element; a first induction coil assembled on the magnetic element; a second induction coil corresponding to the first induction coil, wherein the second induction coil and the first induction coil have the same axis but have no physical contact; a fixing element comprising a first winding base and a motor stator, wherein the magnetic element and the first induction coil are assembled on the first winding base and combined with the motor stator with a first locking element; and a rotating element comprising a second winding base and a motor rotor, wherein the second induction coil is assembled on the second winding base and combined with the motor rotor with a second locking element. Moreover, the above-mentioned transformer device is connected to a plasma generating device to obtain a plasma generating apparatus, and a circular large-area plasma coverage is achieved after rotating.

IPC Classes  ?

  • H01F 27/06 - Mounting, supporting, or suspending transformers, reactors, or choke coils
  • H01F 27/28 - CoilsWindingsConductive connections
  • H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

4.

METHOD FOR PREDICTING PROGNOSTIC INDICATIONS OF PANCREATIC CANCER PATIENTS

      
Application Number 18810801
Status Pending
Filing Date 2024-08-21
First Publication Date 2025-06-19
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Po See
  • Shan, Yan-Shen
  • Yen, Chia-Jui
  • Liu, Ping-Yen
  • Lin, Cheng-Feng

Abstract

The present invention relates to a method for predicting a prognostic indications of pancreatic cancer patient, comprising: providing a sample, wherein the sample is peripheral blood; isolating the sample to obtain an object, wherein the object includes gene loci, protein or blood cell; detecting a reference parameter from the object for estimating a prognostic indicators of pancreatic cancer patient; and estimating the prognostic indications of pancreatic cancer patient by using a model.

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
  • G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
  • G16H 10/20 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for electronic clinical trials or questionnaires
  • G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records

5.

INTELLIGENT ENERGY MANAGEMENT SYSTEM AND METHOD THEREOF

      
Application Number 18801850
Status Pending
Filing Date 2024-08-13
First Publication Date 2025-06-12
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Tieng, Hao
  • Ou, Ting-Chia
  • Cheng, Fan-Tien

Abstract

Based on the hybrid architecture of green intelligent manufacturing (GiM), a generic framework for an intelligent energy management system (iEMS) includes the relationships, objective function, and constraints among stage I: production scheduling, stage II: facility control, and stage III: microgrid integration. iEMS uses the cyber-physical agent (CPA) to collect the big data required in the three stages. In particular, the production scheduling results of stage I are inputted to stage II for facility control. Then, the optimal energy baseline generated from the first two stages, are inputted to stage III. At the same time, iEMS interacts with the intelligent carbon-emission management system (iCMS) to consider indirect carbon emission costs and direct carbon emission costs in three stages. iEMS can minimize the power supply cost of microgrid and help GiM accelerate achieving net zero carbon emissions.

IPC Classes  ?

  • H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks

6.

LASER DEVICE AND LASER GENERATION METHOD

      
Application Number 18434834
Status Pending
Filing Date 2024-02-07
First Publication Date 2025-06-12
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chu, Shu-Chun
  • Tsai, Zheng Xian
  • Chang, Kuo-Chih

Abstract

A laser device includes an energy supply unit used to generate an initial light beam, a beam splitting unit, reflection units, an optical switch unit and an optical modulation unit. The beam splitting unit split the initial light beam into a first input light beam and a second input light beam. The reflection units are respectively disposed on propagation paths of the first input light beam and the second input light beam to form a first resonance cavity and a second resonance cavity, where the first resonance cavity and the second resonance cavity are respectively used to reflect the first input light beam and the second input light beam back and forth. The optical switch unit transforms the first input light beam into a pulsed laser. The optical modulation unit controls an output optical field of the first input light beam and the second input light beam.

IPC Classes  ?

  • H01S 3/106 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling devices placed within the cavity
  • H01S 3/11 - Mode lockingQ-switchingOther giant-pulse techniques, e.g. cavity dumping

7.

SINGLE-INDUCTOR BIPOLAR-OUTPUT CONVERTER

      
Application Number 18531533
Status Pending
Filing Date 2023-12-06
First Publication Date 2025-06-12
Owner
  • National Cheng Kung University (Taiwan, Province of China)
  • Himax Technologies Limited (Taiwan, Province of China)
Inventor
  • Cai, Meng-Xun
  • Tsai, Chien-Hung

Abstract

A single-inductor bipolar-output converter includes a power stage that generates a positive output voltage and a negative output voltage; a first error amplifier that generates a first error signal according to the positive output voltage; a second error amplifier that generates a second error signal according to the negative output voltage; a summation device that generates a sum signal by adding the first error signal and the second error signal; and a tunable gain control circuit coupled to receive the first error signal and configured to generate an amplified first error signal with a tunable gain.

IPC Classes  ?

  • H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
  • H02M 1/00 - Details of apparatus for conversion

8.

NEGATIVE PRESSURE WOUND THERAPY ADVISORY SYSTEM, NEGATIVE PRESSURE WOUND THERAPY METHOD AND NON-TRANSITORY COMPUTER-READABLE MEDIA

      
Application Number 18795289
Status Pending
Filing Date 2024-08-06
First Publication Date 2025-06-12
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Wu, Chia-Ching
  • Wang, Shyh-Hau
  • Huang, Da-Ming
  • Huang, Wan-Ching
  • Pan, Shin-Chen
  • Hung, Kuo-Shu
  • Lee, I Ying

Abstract

A negative pressure therapy advisory system and a negative pressure therapy method by using the advisory system are provided. The method includes: an image preprocessing step and a dressing advisory step. The image preprocessing step includes: an image correction step, an image segmentation step and an image classification step to build a wound model, and to determine a wound injury degree, a wound shape, and blood vessels or anatomical tissue landmarks. The dressing advisory step provides a dressing geometry of a dressing shape in accordance with the wound model, in which the wound/dressing shape is a 2D shape or 3D shape. The method further includes: performing a negative pressure advisory step with respect to negative pressure wound therapy of the wound, or correcting colors of a wound pattern in the wound image by using a color reference calibrator. The system is configured to perform the above method.

IPC Classes  ?

  • A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
  • G06T 7/00 - Image analysis
  • G06T 7/10 - SegmentationEdge detection
  • G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

9.

VIRTUAL METROLOGY METHOD BASED ON A LONG SEQUENCE TIME-SERIES PREDICTION FRAMEWORK AND SYSTEM THEREOF

      
Application Number 18805548
Status Pending
Filing Date 2024-08-15
First Publication Date 2025-06-12
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Tieng, Hao
  • Yang, Haw-Ching
  • Cheng, Fan-Tien

Abstract

Right decisions can only be made via understanding future trends. For example, energy consumption prediction is the basis of all Energy Management Systems (EMS). Any EMS decision-making must rely on the energy consumption prediction value for subsequent power grid planning or factory management. These prediction values play decisive roles in planning and management. A virtual metrology method based on a long sequence time-series prediction framework develops the Automatic Virtual Metrology (AVM) which can provide accurate predictive future trends to increase decision-making accuracy (such as production scheduling or facility control). The built-in period calculator module is used to automatically find out a best memorizing length, a best forecasting length and a best full-periodic pattern length for the long sequence time-series prediction framework. The procedure of advanced dual-phase algorithm is enhanced to achieve self-updating with time for the AVM based on the long sequence time-series prediction framework.

IPC Classes  ?

  • G06F 30/18 - Network design, e.g. design based on topological or interconnect aspects of utility systems, piping, heating ventilation air conditioning [HVAC] or cabling
  • G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme

10.

METHOD FOR PROCESSING SUBSTRATE BY USING LASER AND SYSTEM THEREOF

      
Application Number 18960038
Status Pending
Filing Date 2024-11-26
First Publication Date 2025-06-12
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Lo, Yu-Lung
  • Karnam, Dileep
  • Yang, Chia-Hua

Abstract

The invention provides a method for processing a substrate by using laser, which includes: a substrate providing step, providing a substrate; a fluid applying step, applying a fluid on the substrate; and a laser applying step, applying a laser to the substrate under the fluid so as to perform a laser processing on the substrate, wherein the types of laser processing include drilling, cutting, grooving, trimming or trenching. At the same time, the present invention also discloses a system for processing a substrate by using laser. Through the selection of different fluid types, the present invention can achieve different laser processing effects so as to meet market demands.

IPC Classes  ?

  • G06N 3/0475 - Generative networks
  • B23K 26/14 - Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beamNozzles therefor
  • B23K 26/38 - Removing material by boring or cutting
  • B23K 101/40 - Semiconductor devices

11.

GRIP STRENGTH TRAINING AND MEASURING DEVICE

      
Application Number 18926824
Status Pending
Filing Date 2024-10-25
First Publication Date 2025-06-05
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chang, Chien-Hsiang
  • Lin, Yang-Cheng
  • Kuo, Yen-Chieh
  • Wu, Pei-Yun
  • Wu, Po-Ting
  • Lien, Wei-Chih
  • Liu, Bo

Abstract

A grip strength training and measuring device includes a main body configured for fingers to abut against and press, a penetrating hole penetrating through the main body to define a accommodating space, a pressure sensor arranged in the accommodating space and including a pressure sensing unit to detect a pressure magnitude and a pressing time transmitting from the main body to the pressure sensor when fingers press the main body and to output pressure measurement data, a processor electrically connected to the pressure sensing unit to receive the pressure measurement data, and a feedback device electrically connected to the processor to generate a first feedback, under a control of the processor, when the pressure measurement data does not reach a predetermined value, and to generate a second feedback differing from the first feedback, under the control of the processor, when the pressure measurement data reaches the predetermined value.

IPC Classes  ?

  • A63B 23/16 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously for upper limbs for hands or fingers

12.

DETECTION AND PROTECTION MECHANISM FOR FAKE RELAY STATION IN TELECOMMUNICATION NETWORK

      
Application Number 18960638
Status Pending
Filing Date 2024-11-26
First Publication Date 2025-06-05
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Li, Jung-Shian
  • Liu, I-Hsien
  • Lee, Meng-Huan

Abstract

A detection and protection system for fake relay stations in a telecommunication network comprises a core network, which comprises a threat detection device comprising a radio terminal and a processor; and a plurality of signal relay stations, wherein the radio terminal is communicated with the signal relay stations, the threat detection device performs a wireless signal scanning, and the processor identifies the signal relay stations according to a result of the wireless signal scanning and judges whether there are fake relay stations among the signal relay stations; wherein, the processor decodes the information in the result of the wireless signal scanning, compares the identification information of each signal relay station in the information with a white list, so as to identify whether the signal relay stations include fake relay stations which do not belong to the white list, wherein the white list contains the identification information of legitimate relay stations; and wherein in case that the fake relay stations are identified, the processor sends out an alarming message.

IPC Classes  ?

  • H04W 12/122 - Counter-measures against attacksProtection against rogue devices
  • H04W 12/40 - Security arrangements using identity modules

13.

SYSTEM AND METHOD FOR AUTOMATICALLY CAPTURING AND REPLAYING IMAGES, AND NON-TRANSITORY COMPUTER READABLE STORAGE MEDIUM

      
Application Number 18955013
Status Pending
Filing Date 2024-11-21
First Publication Date 2025-05-29
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Wang, Jeen-Shing
  • Chiang, Wei-Chun
  • Huang, Shih-Chuan

Abstract

A system and method for automatically capturing and replaying images. The method is applied to the system to automatically capture and replay an image of a sporting motion. The system includes a signal sensing device installed at a handheld sport equipment for sensing a sporting motion of the player holding the handheld sport equipment so as to output a sensing signal. The method includes steps of: capturing a sporting video of the sporting motion of the player holding the handheld sport equipment by an image capturing device; identifying a strike motion conforming to a specific strike from the sensing signal by an electronic device; automatically extracting a swing image corresponding to the strike motion from the sporting video captured by the image capturing device by the electronic device; and playing the swing image.

IPC Classes  ?

  • H04N 21/85 - Assembly of contentGeneration of multimedia applications
  • G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
  • G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
  • G06V 10/12 - Details of acquisition arrangementsConstructional details thereof
  • G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
  • G06V 20/40 - ScenesScene-specific elements in video content

14.

Encapsulation Method Using Extracellular Vesicle as Carrier

      
Application Number 18789139
Status Pending
Filing Date 2024-07-30
First Publication Date 2025-05-29
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Hsu, Wei-Hsuan
  • Hsu, Qiao-Yu
  • Lee, Bao-Hong

Abstract

A novel encapsulation method using extracellular vesicles as carriers. When encapsulating required substances, high pressure processing (HPP) is used to greatly increase the encapsulating efficiency of extracellular vesicles, so as to improve the low encapsulating efficiency of traditional passive encapsulation methods. The method is able to improving the use efficiency of required substances, and also having the advantage of the capability to be mass-produced.

IPC Classes  ?

  • A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
  • A61K 38/44 - Oxidoreductases (1)

15.

ADJUSTABLE UPPER LIMB WEARABLE DEVICE

      
Application Number 18926851
Status Pending
Filing Date 2024-10-25
First Publication Date 2025-05-29
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chang, Chien-Hsiang
  • Lin, Yang-Cheng
  • Wu, Pei-Yun
  • Kuo, Yen-Chieh
  • Wu, Po-Ting
  • Lien, Wei-Chih
  • Liu, Bo

Abstract

The present invention provides an adjustable upper limb wearable device including: a main body having a first surface and a second surface, and the first surface is connected to the second surface to form a wearable structure. A positioning hole located on a connection line between the first surface and the second surface. A first sensor fixing bracket configured on the connection line adjacent to the positioning hole, and a first sensor is detachably configured within the first sensor fixing bracket. The adjustable upper limb wearable device can not only be worn easily, but also allow users to quickly position the sensor fixing brackets by aligning the positioning hole with the user's acromion to ensure the sensors are correctly positioned.

IPC Classes  ?

  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • A63B 24/00 - Electric or electronic controls for exercising apparatus of groups
  • A63B 71/06 - Indicating or scoring devices for games or players

16.

Lean-Electrolyte Lithium-Sulfur Cell and a Method of Manufacturing the Same

      
Application Number 18417040
Status Pending
Filing Date 2024-01-19
First Publication Date 2025-05-08
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chung, Sheng-Heng
  • Yu, Guan-Ting

Abstract

The present invention provides a lean-electrolyte lithium-sulfur cell, comprising: a cathode which contains a carbon substrate assembled with a sulfur active material to form a sulfur loading of at least 6 mg/cm2; and an anode which is produced by depositing lithium metal onto a carbon substrate; the carbon substrate of the cathode is a carbon structural material having a carbon nanotube-to-graphene weight ratio of 45:55 to 55:45; the carbon substrate of the anode is a carbon structural material having a carbon nanotube-to-graphene weight ratio of 20:80 to 30:70.

IPC Classes  ?

  • H01M 10/052 - Li-accumulators
  • H01M 4/02 - Electrodes composed of, or comprising, active material
  • H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
  • H01M 4/134 - Electrodes based on metals, Si or alloys
  • H01M 4/36 - Selection of substances as active materials, active masses, active liquids
  • H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators

17.

DETECTION AGENT, DETECTION SYSTEM AND METHOD THEREOF

      
Application Number 18501302
Status Pending
Filing Date 2023-11-03
First Publication Date 2025-05-08
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Syu, Guan-Da
  • Ho, Tzong-Shiann
  • Tsai, Tien-Chun

Abstract

A detection agent, a detection system, and a method thereof are provided. The detection agent includes magnetic barcode beads. Each of the magnetic barcode beads has different two-dimensional edge and is conjugated with a corresponding protein. The protein includes a receptor binding domain of a spike protein or a nucleocapsid protein from a virus or a variant of the virus. The detection system includes the detection agent and a barcode bead fluorescence reader to read a fluorescence signal generated by each of the magnetic barcode beads. The method includes the steps of adding a serum of the subject to the detection agent followed by adding a fluorescently labeled anti-human immunoglobulin antibody and reading a fluorescence signal generated by each of the magnetic barcode beads and discriminating each of the magnetic barcode beads by the barcode bead fluorescence reader to quantify the anti-human immunoglobulin antibody.

IPC Classes  ?

  • G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
  • C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus
  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

18.

TRANSFORMED STRAIN AND METHOD FOR DEGRADING PET BY USING THE SAME

      
Application Number 18938396
Status Pending
Filing Date 2024-11-06
First Publication Date 2025-05-08
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Ng, I-Son
  • Yu, Jie-Yao
  • Ting, Wan-Wen
  • Hsiang, Chuan-Chieh

Abstract

The present invention provides a transformed strain, comprising: a host cell; a first nucleotide sequence, located inside the host cell, the first nucleotide sequence encoding a PETase, which is derived from Ideonella; and a second nucleotide sequence, located inside the host cell, the second nucleotide sequence comprising a first chaperon nucleotide sequence or a second chaperon nucleotide sequence; wherein the first chaperon nucleotide sequence encodes a molecular chaperon protein (GroELS), and the second chaperon nucleotide sequence encodes a lipase secretion chaperone protein (LsC). The present invention also provides a method for degrading plastic, using said transformed strain for degrading a plastic having PET.

IPC Classes  ?

  • C12N 1/20 - BacteriaCulture media therefor
  • C08J 11/10 - Recovery or working-up of waste materials of polymers by chemically breaking down the molecular chains of polymers or breaking of crosslinks, e.g. devulcanisation
  • C12N 9/18 - Carboxylic ester hydrolases
  • C12N 15/70 - Vectors or expression systems specially adapted for E. coli
  • C12R 1/19 - Escherichia coli

19.

MICRONEEDLE, MICRONEEDLE PATCH AND METHOD OF MANUFACTURING A MICRONEEDLE

      
Application Number 18788854
Status Pending
Filing Date 2024-07-30
First Publication Date 2025-05-01
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chen, Mei-Chin
  • Sheu, Ming-Thau
  • Chang, Chih-Chi
  • Yeh, Chien-Chien

Abstract

A microneedle is provided in some embodiments of the present disclosure, including a supporting portion, a needle tip portion and an adhesion layer. The needle tip portion is disposed above the supporting portion, including an active substance. The adhesion layer is disposed between the supporting portion and the needle tip portion, including an adhesive material and a viscosity-reducing substance distributed in the adhesive material. A microneedle patch and a method are further provided in some embodiments of the present disclosure.

IPC Classes  ?

  • A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

20.

Composite Structure, Method for Manufacturing the same and Non-Volatile Optical Memory Device

      
Application Number 18539313
Status Pending
Filing Date 2023-12-14
First Publication Date 2025-05-01
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Chia-Yun
  • Liu, Zhe-Hao
  • Lin, Kuan-Han
  • Li, Jheng-Yi

Abstract

A composite structure includes a dielectric layer, a two-dimensional graphene layer and a carbon quantum dot film. The dielectric layer is disposed on a first surface of a silicon substrate. The two-dimensional graphene layer is disposed on the dielectric layer. The carbon quantum dot film is disposed on the two-dimensional graphene layer.

IPC Classes  ?

  • H01L 29/16 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only elements of Group IV of the Periodic System in uncombined form
  • H10B 69/00 - Erasable-and-programmable ROM [EPROM] devices not provided for in groups , e.g. ultraviolet erasable-and-programmable ROM [UVEPROM] devices

21.

UPPER LIMB REHABILITATION DEVICE

      
Application Number 18418791
Status Pending
Filing Date 2024-01-22
First Publication Date 2025-05-01
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Hsu, Hsiu-Yun
  • Kuo, Li-Chieh
  • Yang, Kang-Chin
  • Chuang, Ping-Han

Abstract

An upper limb rehabilitation device includes a support mechanism, a flexion and extension rehabilitation mechanism, and a twist rehabilitation mechanism. The flexion and extension rehabilitation mechanism includes a sliding seat unit mounted on and movable forwardly and rearwardly relative to the support mechanism, and an arm rest seat mounted on the sliding seat unit for an arm of an upper limb of a patient to rest thereon. The arm rest seat is configured to be actuated by a flexion and extension movement of the arm of the upper limb of the patient to drive forward and rearward movement of the sliding seat unit relative to the support mechanism. The twist rehabilitation mechanism includes a handgrip unit mounted on the sliding seat unit and rotatable leftward and rightward relative to the same for a hand of the upper limb of the patient to grip.

IPC Classes  ?

  • A61H 1/02 - Stretching or bending apparatus for exercising

22.

VERTICAL SMELTING SYSTEM

      
Application Number 18929193
Status Pending
Filing Date 2024-10-28
First Publication Date 2025-05-01
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Lin, Shih-Kang
  • Chiu, Yu-Ning
  • Shiau, Jia-Shyan
  • Cheng, Ping-Chieh
  • Lu, Ke-Miao

Abstract

A vertical smelting system is disclosed by the present disclosure. The vertical smelting system comprises a high-temperature heating device, a reaction sample loading device, a reaction product receiving device, a cooling device, and a transmission device. The reaction sample loading device is detachably connected to the high-temperature heating device, and extends downwardly from the high-temperature heating device. The reaction product receiving device located below the reaction sample loading device is detachably connected to the reaction sample loading device. The cooling device is located below the high-temperature heating device. The transmission device respectively connected to the reaction sample loading device and the reaction product receiving device is configured to drive the reaction sample loading device to move relative to the high-temperature heating device, and is further configured to drive the reaction product receiving device to move relative to the reaction sample loading device.

IPC Classes  ?

23.

ADHESIVE CELL TISSUE GELS

      
Application Number 19011416
Status Pending
Filing Date 2025-01-06
First Publication Date 2025-05-01
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor Huang, Lynn L.H.

Abstract

A cell tissue gel, comprising one or more matrix molecules cross-linked with a cross-linking agent, and a quenching agent bound to a reactive group of the cross-linking agent, wherein the quenching agent contains a moiety that is capable of reacting with the reactive group of the cross-linking agent and the one or more matrix molecules contain one or more functional groups that are capable of cross-linking with the reactive group, the amount of the reactive group of the cross-linking agent being equal to or less than a total amount including the amount of the one or more functional groups and the amount of the moiety.

IPC Classes  ?

  • A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
  • A61K 38/18 - Growth factorsGrowth regulators
  • A61K 38/19 - CytokinesLymphokinesInterferons
  • A61K 38/30 - Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
  • A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
  • A61L 24/08 - Polysaccharides
  • A61L 24/10 - PolypeptidesProteins
  • A61L 27/20 - Polysaccharides
  • A61L 27/22 - Polypeptides or derivatives thereof
  • A61L 27/24 - Collagen
  • A61L 27/38 - Animal cells
  • A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
  • A61L 27/52 - Hydrogels or hydrocolloids
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • C08B 11/02 - Alkyl or cycloalkyl ethers
  • C08B 11/12 - Alkyl or cycloalkyl ethers with substituted hydrocarbon radicals substituted with acid radicals substituted with carboxylic radicals
  • C08B 15/00 - Preparation of other cellulose derivatives or modified cellulose
  • C08B 15/10 - Crosslinking of cellulose
  • C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
  • C08B 37/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
  • C08G 12/46 - Block or graft polymers prepared by polycondensation of aldehydes or ketones on to macromolecular compounds
  • C08G 69/10 - Alpha-amino-carboxylic acids
  • C08H 1/00 - Macromolecular products derived from proteins
  • C08H 1/06 - Macromolecular products derived from proteins derived from horn, hoofs, hair, skin, or leather
  • C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
  • C08L 77/04 - Polyamides derived from alpha-amino carboxylic acids
  • C08L 89/06 - Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
  • C09J 105/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
  • C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

24.

METHOD OF BONDING MULTIPLE COPPER ELEMENTS AND METHOD OF BONDING MULTIPLE DIELECTRIC LAYERS

      
Application Number 18910945
Status Pending
Filing Date 2024-10-09
First Publication Date 2025-04-17
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Lin, Shih-Kang

Abstract

A method of bonding multiple copper elements and a method of bonding multiple dielectric layers are disclosed. The method of bonding multiple copper elements comprises steps of: oxidizing a first copper element to form a first copper oxide structure on a surface of the first copper element, and oxidizing a second copper element to form a second copper oxide structure on a surface of the second copper element; immersing the first copper element and the second copper element into a reaction solution containing noble metal ions for a Galvanic reaction, so that the first copper oxide structure is replaced with a first noble metal oxide structure, and the second copper oxide structure is replaced with a second noble metal oxide structure; and bonding the first noble metal oxide structure and the second noble metal oxide structure, so that the first copper component and the second copper component are connected.

IPC Classes  ?

25.

SEMI-SOLID ALLOY THERMAL INTERFACE COMPOSITION AND METHOD FOR DISSIPATING HEAT FROM AN ELECTRONIC COMPONENT USING THE SAME

      
Application Number 18913190
Status Pending
Filing Date 2024-10-11
First Publication Date 2025-04-17
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Lin, Shih-Kang
  • Huang, Chih-Yao
  • Yang, Chih-Han

Abstract

A semi-solid alloy thermal interface composition and method for dissipating heat from an electronic component using the same are disclosed in the present disclosure. The semi-solid alloy thermal interface material comprises, based on total atoms of 100 at. %, 0.1-10 at. % of Bi, 20-30 at. % of In, and 65-75 at. % of Sn. In a method for dissipating heat from an electronic component using the semi-solid alloy thermal interface material, the semi-solid alloy thermal interface material is disposed between a chip and a heat sink, wherein the semi-solid alloy thermal interface material is completely solid at a room-temperature, and has a liquid content ranging from 0.1 to 70 mol % based on a total mole of 100 mol % of the semi-solid alloy thermal interface composition at a temperature of 40 to 130° C.

IPC Classes  ?

  • H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
  • C22C 13/02 - Alloys based on tin with antimony or bismuth as the next major constituent
  • C22C 28/00 - Alloys based on a metal not provided for in groups
  • C22C 30/02 - Alloys containing less than 50% by weight of each constituent containing copper
  • C22C 30/04 - Alloys containing less than 50% by weight of each constituent containing tin or lead

26.

USE AND DETECTION METHOD OF FLAVIVIRUS PROTEIN MICROARRAY

      
Application Number 18480009
Status Pending
Filing Date 2023-10-03
First Publication Date 2025-04-03
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Syu, Guan-Da
  • Ho, Tzong-Shiann

Abstract

A use and detection method of flavivirus protein microarray are provided. The flavivirus protein microarray having an amino acid sequence of SEQ ID NO: 1, an amino acid sequence of SEQ ID NO: 3, and an amino acid sequence of SEQ ID NO: 13 may be used to distinguish dengue patients with mild case from hospitalized case. The flavivirus protein microarray having an amino acid sequence of SEQ ID NO: 3 and an amino acid sequence of SEQ ID NO: 4 may be used to distinguish dengue patients with mild case and hospitalized non-severe case from hospitalized severe case. The method for distinguishing dengue patients with mild case from hospitalized case comprises steps of providing the flavivirus protein microarray, subsequently adding a non-protein blocking reagent, a serum of the dengue patient, and a fluorescently labeled anti-human immunoglobulin antibody to the flavivirus protein microarray and reading an optical signal.

IPC Classes  ?

  • G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
  • G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

27.

PULSED-PLASMA THRUSTER USING UNBALANCED THETA-PINCH

      
Application Number 18404653
Status Pending
Filing Date 2024-01-04
First Publication Date 2025-03-27
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chang, Po-Yu
  • Chen, Te-Yueh

Abstract

A pulsed-plasma thruster using an unbalanced theta-pinch includes a gas-puff generator, an ionization convergent-divergent nozzle, and an accelerating coil set. The gas-puff generator supplies a gas puff in a pulsed manner; and the accelerating coil set is arranged on a side of a throat of the ionization convergent-divergent nozzle. After the gas puff enters the ionization convergent-divergent nozzle, an electric arc is generated between the pair of electrodes of the ionization convergent-divergent nozzle so that the gas puff is ionized and forms a plasma plume, and the electrodes are utilized to drive the accelerating coil set to generate axially non-uniform magnetic fields, to accelerate the plasma plume. Based on this, the control of thrust force generation is simple and reliable, with high energy utilization efficiency.

IPC Classes  ?

  • F03H 1/00 - Use of plasma to produce a reactive propulsive thrust

28.

SINGLE-LAYERED HOLLOW TRANSMISSION SHAFT

      
Application Number 18368121
Status Pending
Filing Date 2023-09-14
First Publication Date 2025-03-20
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Lan, Chao-Chieh

Abstract

A single-layered hollow transmission shaft comprises a hollow shaft body. The hollow shaft body has a power-inputting end and a power-outputting end, which are formed at two opposite ends of the hollow shaft body, and at least one multi-start helix set. The multi-start helix set has a left-coiling multi-start helix section and a right-coiling multi-start helix section, which are arranged axially and have an equal pitch, number of circles, number of starts of helix and width of helix. By a single-layered structure and a structural design of the multi-start helix set, the single-layered hollow transmission shaft provides sufficient space for wiring of communication and can transmit power with pure torque while the shaft rotates, therefore increasing precision of torque detection, and can detect torque while rotating at high speed without installing any other external element and without affecting size of the space inside the shaft.

IPC Classes  ?

29.

BIOELECTRIC NEUROMODULATION METHODS AND SYSTEMS FOR NEUROPATHIC PAIN RELIEF

      
Application Number 18957670
Status Pending
Filing Date 2024-11-23
First Publication Date 2025-03-20
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Liu, Wentai
  • Shen, Meng-Ru
  • Lee, Jung-Shun
  • Wong, Chia-En
  • Chen, Li-Hsien
  • Hsu, Ya-Ting

Abstract

A method and system device to generate and deliver an electric field to a target a peripheral nerve with customized electric fields according to the nerve of interest, which may be superficial or deep in the human body, to elicits action potentials of the target nerve. The system utilizes a stimulator circuit which receives parameters of a stimulation protocol from an external control device, and assembles basic building waveforms, counters, and timers which when combined are directed to a current/voltage driver hardware (CDC) that generates the stimulation protocol.

IPC Classes  ?

  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

30.

METAL-NANOPARTICLE-FREE SURFACE-ENHANCED RAMAN SCATTERING SUBSTRATE, AND A METHOD OF MANUFACTURING THE SAME

      
Application Number 18386176
Status Pending
Filing Date 2023-11-01
First Publication Date 2025-02-27
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chung, Chen-Kuei
  • Yu, Chung-Yu
  • Ku, Chin-An

Abstract

The present invention provides a metal-nanoparticle-free surface-enhanced Raman scattering substrate, which comprises: an anodic aluminum oxide substrate with three-dimensional cavities, and a metal nano-film on the anodic aluminum oxide substrate. The surface-enhanced Raman scattering substrate of the present invention does not need to use metal nanoparticles, but instead uses a structure of metal nanofilm to generate a surface plasmonic resonance. Therefore, compared with the traditional surface-enhanced Raman scattering substrate with an addition of metal nanoparticles, the surface-enhanced Raman scattering substrate of the present invention has better uniformity, stability and reproducibility. The present invention utilizes an anodic aluminum oxide substrate with three-dimensional cavities, so that the surface-enhanced Raman scattering substrate has high sensitivity, high stability, and high reproducibility. The present invention also provides a method of manufacturing the substrate with simple procedure, which allows a rapid manufacturing process and makes the surface-enhanced Raman scattering substrate with three-dimensional cavities.

IPC Classes  ?

  • C25D 11/12 - Anodising more than once, e.g. in different baths
  • B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

31.

FOOD DETECTION SYSTEM AND FOOD DETECTION METHOD

      
Application Number 18386163
Status Pending
Filing Date 2023-11-01
First Publication Date 2025-02-27
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chung, Chen-Kuei
  • Yu, Chung-Yu
  • Lin, Ding-Yan

Abstract

The present invention provides a food detection system including: an extraction equipment, a liquid to be identified, a laser light source, a Raman spectrometer, and a metal-nanoparticle-free surface-enhanced Raman scattering substrate. Without an addition of metal nanoparticles, the surface-enhanced Raman scattering substrate of the present invention has better stability and reproducibility compared to those traditional surface-enhanced Raman scattering substrate with metal nano particles. The present invention utilizes an anodic aluminum oxide substrate with two-dimensional and three-dimensional cavities, so that the surface-enhanced Raman scattering substrate has high sensitivity, high stability, and high reproducibility, and may therefore shorten the detection time and production cost of food detection. The invention also provides a food detection method using the food detection system, which is cheap, fast, stable and reliable.

IPC Classes  ?

32.

ACCELERATOR SYSTEM AND METHOD TO EXECUTE DEPTHWISE SEPARABLE CONVOLUTION

      
Application Number 18509381
Status Pending
Filing Date 2023-11-15
First Publication Date 2025-02-20
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Chung-Ho
  • Xie, Cheng-You

Abstract

An accelerator system includes an off-chip memory, a bus, and an accelerator. The off-chip memory includes a first buffer. The accelerator includes a second buffer, a third buffer, a fourth buffer, an instruction fetching module, a load module, a storage module, a convolution control module, and a computation module. The instruction fetching module fetches instructions from the off-chip memory via the bus. The load module loads input data from the off-chip memory via the bus. The storage module stores the output data to the off-chip memory via the bus. The computation module performs convolution computations based on the input map and multiple kernels allocated by the convolution module. In response to loading the input data or instruction from the off-chip memory, the requested input data or instruction is transferred from the off-chip memory and temporarily stored in the first buffer.

IPC Classes  ?

  • G06F 13/16 - Handling requests for interconnection or transfer for access to memory bus
  • G06F 7/544 - Methods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using non-contact-making devices, e.g. tube, solid state deviceMethods or arrangements for performing computations using exclusively denominational number representation, e.g. using binary, ternary, decimal representation using unspecified devices for evaluating functions by calculation
  • G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead

33.

Multiple-reference-embedded comparator and comparison method thereof

      
Application Number 18234874
Grant Number 12308843
Status In Force
Filing Date 2023-08-16
First Publication Date 2025-02-20
Grant Date 2025-05-20
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Wang, Jia-Ching
  • Kuo, Tai-Haur

Abstract

A multiple-reference-embedded comparator (MREC) circuit includes a tail current source circuit; an input transistor pair, coupled to the tail current source circuit, configured to receive differential input voltages and perform a first pre-amplification to generate first differential amplified voltages according to the differential input voltages; and a plurality of embedded reference (ER) branches, each coupled to the input transistor pair, each configured to perform a second pre-amplification to generate second differential amplified voltages according to the first differential amplified voltages, and to perform a discrete-time comparison to generate differential output voltages according to the second differential amplified voltages.

IPC Classes  ?

  • H03K 5/24 - Circuits having more than one input and one output for comparing pulses or pulse trains with each other according to input signal characteristics, e.g. slope, integral the characteristic being amplitude

34.

METHODS OF TREATING PANCREATIC CANCER BY USING BET INHIBITOR AND PARP INHIBITOR

      
Application Number 18523965
Status Pending
Filing Date 2023-11-30
First Publication Date 2025-02-13
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Shan, Yan-Shen
  • Su, Wen-Pin
  • Hou, Ya-Chin

Abstract

Disclosed herein is a method of treating a pancreatic cancer in a subject who is responsive to a platinum-based therapy. The method comprises administering to the subject an effective amount of a BET inhibitor and an effective amount of a PARP inhibitor. According to some embodiments of the present disclosure, the BET inhibitor is mivebresib, JQ1, or AZD5153, and the PARP inhibitor is rucaparib, veliparib, or olaparib.

IPC Classes  ?

  • A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
  • A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
  • A61P 35/00 - Antineoplastic agents

35.

METHOD FOR PRODUCING SUSTAINABLE AVIATION FUEL

      
Application Number 18486371
Status Pending
Filing Date 2023-10-13
First Publication Date 2025-02-06
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Wang, Wei-Cheng

Abstract

A method for producing a sustainable aviation fuel includes (a) subjecting a feedstock containing an oil to a first reaction with hydrogen in the presence of a first catalyst so that the oil is hydrogenated to saturation and deoxygenated, thereby obtaining a first product containing hydrocarbons, the first reaction being carried out at a temperature ranging from 385° C. to 415° C.; and (b) subjecting the first product to a second reaction with hydrogen in the presence of a second catalyst so that the hydrocarbons in the first product are cracked and isomerized, thereby obtaining the sustainable aviation fuel, the second catalyst including a silicoaluminophosphate-11 (SAPO-11) carrier loaded with nickel and citric acid, the nickel being present in an amount ranging from 12 wt % to 30 wt % based on 100 wt % of the second catalyst.

IPC Classes  ?

  • C10G 3/00 - Production of liquid hydrocarbon mixtures from oxygen-containing organic materials, e.g. fatty oils, fatty acids
  • B01J 23/755 - Nickel
  • B01J 29/85 - Silicoaluminophosphates [SAPO compounds]
  • B01J 37/02 - Impregnation, coating or precipitation
  • C10G 45/64 - Refining of hydrocarbon oils using hydrogen or hydrogen-generating compounds to change the structural skeleton of some of the hydrocarbon content without cracking the other hydrocarbons present, e.g. lowering pour pointSelective hydrocracking of normal paraffins characterised by the catalyst used containing crystalline alumino-silicates, e.g. molecular sieves
  • C10G 47/20 - Crystalline alumino-silicate carriers the catalyst containing other metals or compounds thereof

36.

MEDICAL IMAGE-BASED SYSTEM FOR PREDICTING LESION CLASSIFICATION, AND METHOD FOR USING THEREOF

      
Application Number 18429759
Status Pending
Filing Date 2024-02-01
First Publication Date 2025-01-30
Owner
  • National Cheng Kung University (Taiwan, Province of China)
  • National Cheng Kung University Hospital (Taiwan, Province of China)
Inventor
  • Tsai, Yi-Shan
  • Lai, Yu-Hsuan
  • Lai, Cheng-Shih
  • Chen, Chao-Yun
  • Wu, Meng-Jhen
  • Lin, Yi-Chuan
  • Chiang, Yi-Ting
  • Fang, Peng-Hao
  • Kuo, Po-Tsun
  • Chiu, Yi-Chih

Abstract

The present invention disclose a medical image-based system for predicting lesion classification and a method thereof. The system comprises a feature data extracting module for providing a raw feature data based on a medical image, and a predicting module for outputting a predicted class and a risk index according to the raw feature data. The predicting module comprises a classification unit for generating the predicted class and a prediction score corresponding thereto according to the raw feature data, and a risk evaluation unit for generating the risk index according to the prediction score. The system provides medical personnels a reference score and a risk index to determine progression of a certain disease.

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G06T 7/00 - Image analysis
  • G06V 10/40 - Extraction of image or video features
  • G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

37.

SHEAR MODE PIEZOELECTRIC ACCELEROMETER

      
Application Number 18457919
Status Pending
Filing Date 2023-08-29
First Publication Date 2025-01-30
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Li, Cheng-Ying
  • Chu, Sheng-Yuan

Abstract

A shear mode piezoelectric accelerometer includes a ring-shaped piezoelectric element, a central shaft, a mass block, a first electrode, and a second electrode. The ring-shaped piezoelectric element includes an outer ring wall and an inner ring wall. The central shaft is made of conductive material and is fixed through the inner ring wall of the ring-shaped piezoelectric element. The mass block is made of conductive material and includes a fixed element and a weight element. The fixed element has a fixed hole and is fixed to the outer ring wall of the ring-shaped piezoelectric element by fitting the fixed hole. The weight element is located on the fixed element on the opposite side away from the fixed hole. The first electrode is electrically connected to the central shaft. The second electrode is electrically connected to the mass block.

IPC Classes  ?

  • G01P 15/09 - Measuring accelerationMeasuring decelerationMeasuring shock, i.e. sudden change of acceleration by making use of inertia forces with conversion into electric or magnetic values by piezoelectric pick-up
  • G01P 1/02 - Housings

38.

METHOD FOR PRODUCING ENERGETIC GAS FROM CARBON DIOXIDE

      
Application Number 18493352
Status Pending
Filing Date 2023-10-24
First Publication Date 2025-01-30
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Wang, Wei-Cheng
  • Yang, Yung-Hsiang

Abstract

A method for producing an energetic gas from carbon dioxide includes the steps of: impregnating a plurality of alumina particles into a nickel-based aqueous solution to form a crude product, followed by subjecting the crude product to a drying treatment and then to a calcination treatment at a temperature ranging from 550° C. to 650° C., so as to obtain a supported catalyst; activating the supported catalyst with hydrogen, so as to obtain an activated supported catalyst; and subjecting hydrogen and carbon dioxide to a methanation reaction at a total gas hourly space velocity ranging from 4000 h−1 to 5000 h−1 in the presence of the activated supported catalyst, so as to form methane serving as an energetic gas.

IPC Classes  ?

  • C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen
  • B01J 21/04 - Alumina
  • B01J 23/755 - Nickel
  • B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/08 - Heat treatment
  • B01J 37/18 - Reducing with gases containing free hydrogen

39.

ACOUSTIC METASURFACE STRUCTURE

      
Application Number 18353949
Status Pending
Filing Date 2023-07-18
First Publication Date 2025-01-23
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chen, Jung-San
  • Kuo, Tzu-Huei
  • Wang, Wei-Chun
  • Lo, Wen-Yang
  • Wang, Cheng-Yi

Abstract

An acoustic metasurface structure is configured to absorb sounds. The acoustic metasurface structure comprises a main body, an externally-connecting configuration and an inner configuration. The externally-connecting configuration and the inner configuration are respectively formed inside the main body. An externally-connecting tube of the externally-connecting configuration is in fluid communication with an external environment and an externally-connecting cavity of the externally-connecting configuration. An inner tube of the inner configuration is in fluid communication with the externally-connecting cavity and an inner cavity of the inner configuration. With the externally-connecting configuration and the inner configuration forming a series-type structure in the main body, the acoustic metasurface structure increases an acoustic impedance. Therefore, under circumstances of the main body having a limited volume, frequencies, on which absorption coefficient peaks of the acoustic metasurface structure land, are lowered, and an absorption coefficient of the acoustic metasurface structure toward low frequencies is increased.

IPC Classes  ?

  • G10K 11/172 - Methods or devices for protecting against, or for damping, noise or other acoustic waves in general using resonance effects
  • G10K 11/162 - Selection of materials
  • G10K 11/36 - Devices for manipulating acoustic surface waves

40.

FLOW GUIDING DEVICE FOR CARBON CAPTURE SYSTEM

      
Application Number 18499740
Status Pending
Filing Date 2023-11-01
First Publication Date 2025-01-23
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Wang, Wei-Cheng

Abstract

A flow guiding device for a carbon capture system includes a connecting unit and a flow guiding unit connected to the connecting unit. The connecting unit includes a communicating member defining a gas flow channel, a main housing diverging gradually from the communicating member, and a gas rectifier disposed opposite to the communicating member and having a plurality of air holes. The flow guiding unit includes a guiding member defining an flow channel in fluid communication with the gas flow channel and having a plurality of through holes in fluid communication with the flow channel, a main body diverging gradually from the guiding member, and a flow disturbing member disposed at a terminal portion of the main body and having a plurality of flow distributing holes. The main body cooperates with the main housing to define an annular flow channel therebetween that is in fluid communication with the through holes.

IPC Classes  ?

  • B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

41.

HUMAN INDUCED PLURIPOTENT STEM CELLS-DIFFERENTIATED CARDIOMYOCYTES, METHODS OF PRODUCING THE SAME, AND USES THEREOF IN TREATING CARDIAC DISEASES

      
Application Number 18353885
Status Pending
Filing Date 2023-07-18
First Publication Date 2025-01-23
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Liu, Yen-Wen
  • Shan, Yan-Shen

Abstract

Disclosed herein is an isolated population of cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs), wherein the isolated population of cardiomyocytes comprises genomic deletions in HCN1 and HCN4 genes. According to some embodiments of the present disclosure, the isolated population of cardiomyocytes further comprises genomic deletions in HCN2 and HCN3 genes. Also disclosed herein are methods of producing the isolated population of cardiomyocytes, and methods of treating subjects suffering from cardiac diseases by administering the isolated population of cardiomyocytes to the subjects.

IPC Classes  ?

  • A61K 35/34 - MusclesSmooth muscle cellsHeartCardiac stem cellsMyoblastsMyocytesCardiomyocytes
  • A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
  • C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
  • C12N 9/22 - Ribonucleases
  • C12N 15/11 - DNA or RNA fragmentsModified forms thereof
  • C12N 15/90 - Stable introduction of foreign DNA into chromosome

42.

OFFSET OVERLAP TYPE OF MODULATED FERROMAGNETIC POLE PIECE RING AND METHOD THEREOF

      
Application Number 18631126
Status Pending
Filing Date 2024-04-10
First Publication Date 2025-01-16
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Tsai, Mi-Ching
  • Huang, Po-Wei
  • Yang, Wen-Hao
  • Chang, Tsung-Wei

Abstract

An offset overlap type of a modulated ferromagnetic pole piece ring and a manufacturing method thereof are provided. The modulated ferromagnetic pole piece ring comprises a plurality of ring pieces overlapped with each other. At least one ring piece comprises a plurality of main ribs, a plurality of inner ribs, and a plurality of outer ribs. The main ribs are arranged in a circular manner with intervals in between, and a plurality of first gaps and a plurality of second gaps are formed alternately between the main ribs, wherein the inner ribs are respectively located in the first gaps, and the outer ribs are respectively located in the second gaps.

IPC Classes  ?

  • H02K 49/10 - Dynamo-electric clutchesDynamo-electric brakes of the permanent-magnet type

43.

MULTI-DIMENSIONAL STRAIN SENSING DEVICE, METHOD FOR SENSING TYPES OF EXTERNAL MOTIONS AND FOR FORMING TERNARY VALUED LOGIC DEVICE BY THE SAME, AND TERNARY VALUED LOGIC SYSTEM

      
Application Number 18219300
Status Pending
Filing Date 2023-07-07
First Publication Date 2025-01-09
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Dutta, Jit
  • Liu, Chuan Pu

Abstract

A multi-dimensional strain sensing device includes a flexible substrate, two piezoelectric semiconducting films, a first pair of electrodes and a second pair of electrodes. The two piezoelectric semiconducting films are formed on opposite sides of the flexible substrate respectively. The first pair of electrodes are formed on one of the two piezoelectric semiconducting films and opposite to the flexible substrate. The second pair of electrodes are formed on the other one of the two piezoelectric semiconducting films and opposite to the flexible substrate. The present disclosure further proposes a method for sensing types of external motions by the multi-dimensional strain sensing device, a method for forming a ternary valued logic device by the multi-dimensional strain sensing device and a ternary valued logic system.

IPC Classes  ?

  • G01L 1/16 - Measuring force or stress, in general using properties of piezoelectric devices

44.

ORGANIC/INORGANIC COMPOSITE STRUCTURE, METHOD FOR MANUFACTURING THE SAME AND SENSING DEVICE

      
Application Number 18227323
Status Pending
Filing Date 2023-07-28
First Publication Date 2024-12-12
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Chia-Yun
  • Li, Jheng-Yi
  • Wu, Tsung-Yen

Abstract

An organic/inorganic composite structure includes a silicon substrate and a conductive polymer layer. The silicon substrate includes a plurality of microstructures disposed on a surface of the silicon substrate. The conductive polymer layer is disposed on the plurality of microstructures. A spaced distance is between the conductive polymer layer and the surface of the silicon substrate.

IPC Classes  ?

  • H10K 39/00 - Integrated devices, or assemblies of multiple devices, comprising at least one organic radiation-sensitive element covered by group
  • H10K 39/30 - Devices controlled by radiation
  • H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating

45.

Antibody Binding to CHI3L1 for Treating Cancer

      
Application Number 18698648
Status Pending
Filing Date 2022-09-30
First Publication Date 2024-12-05
Owner
  • National Cheng Kung University (Taiwan, Province of China)
  • AP Biosciences, Inc. (Taiwan, Province of China)
Inventor
  • Wang, Yi-Ching
  • Chang, Chih-Peng
  • Su, Pei-Chia
  • Kuo, I-Ying
  • You, Jhong-Jhe
  • Her, Jeng-Horng

Abstract

An antibody or an antigen-binding portion thereof binding to CHI3L1 includes a heavy chain variable region and a light chain variable region. The antibody or the antigen-binding portion thereof targeting CHI3L1 not just inhibit activated AKT and ERK signals, cancer cells migration, tumor progression, tumor fibrosis, angiogenesis and cancer-induced muscle loss such as cachexia, but modulate TME toward an immunostimulatory phenotype.

IPC Classes  ?

  • C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
  • A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
  • A61K 39/00 - Medicinal preparations containing antigens or antibodies
  • A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
  • A61P 35/00 - Antineoplastic agents

46.

PIPELINE FOR SEPARATION AND DETECTION OF ULTRASHORT SINGLE-STRANDED CELL-FREE DNA

      
Application Number US2024030795
Publication Number 2024/243418
Status In Force
Filing Date 2024-05-23
Publication Date 2024-11-28
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Cheng, Jordan
  • Wong, David
  • Huang, Allen
  • Swarup, Neeti
  • Choi, Irene

Abstract

A method of isolating ultrashort single-stranded cell-free DNA (uscfDNA) separately from other cell-free DNA, such as mononucleosomal cell-free DNA (mncfDNA) is described as well as methods of using the isolated mncfDNA and uscfDNA for detecting biomarkers and diagnosing diseases and disorders.

IPC Classes  ?

  • C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
  • C12N 15/11 - DNA or RNA fragmentsModified forms thereof
  • C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
  • C12Q 1/686 - Polymerase chain reaction [PCR]
  • C12Q 1/6869 - Methods for sequencing
  • C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof

47.

INVERTER-BASED COMPARATOR

      
Application Number 18797259
Status Pending
Filing Date 2024-08-07
First Publication Date 2024-11-28
Owner
  • National Cheng Kung University (Taiwan, Province of China)
  • Himax Technologies Limited (Taiwan, Province of China)
Inventor
  • Fan, Philex Ming-Yan
  • Chen, Yi-Fu
  • Chen, Bo-Rui

Abstract

An inverter-based comparator includes an output stage circuit including a P-type output transistor and an N-type output transistor; a first inverter having a first transition voltage with an input node coupled to an input voltage and an output node generating a first inverted voltage and coupled to a gate of the N-type output transistor; and a second inverter having a second transition voltage with an input node coupled to the input voltage and an output node generating a second inverted voltage and coupled to a gate of the P-type output transistor. The first inverter and the second inverter each includes an inverter that includes a first inverter branch composed of at least one first P-type transistor and at least one first N-type transistor; and a second inverter branch composed of at least one second P-type transistor, at least one second N-type transistor and at least two tuning switches.

IPC Classes  ?

  • H03K 5/24 - Circuits having more than one input and one output for comparing pulses or pulse trains with each other according to input signal characteristics, e.g. slope, integral the characteristic being amplitude

48.

GASEOUS FUEL PRODUCTION SYSTEM

      
Application Number 18473508
Status Pending
Filing Date 2023-09-25
First Publication Date 2024-11-21
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Wang, Wei-Cheng

Abstract

A gaseous fuel production system is adapted for producing a gaseous fuel from an object, and includes at least two adsorbing devices, a mixture space, a first detector, an air extractor pump, and a second detector. The at least two adsorbing devices are adapted for adsorbing a target gas. Each of the mixture space and the air extractor pump is connected downstream of the at least two adsorbing devices. Each of the at least two adsorbing devices is convertible between an adsorbing state, in which the adsorbing device adsorbs the target gas and the first detector measures a first concentration of the target gas in the mixture space, and a desorption state, in which the target gas is extracted from the adsorbing device by the air extractor pump and the second detector measures a second concentration of the target gas in a fluid located downstream of the air extractor pump.

IPC Classes  ?

  • C01B 3/22 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of gaseous or liquid organic compounds

49.

L-SHAPED FIELD EFFECT TRANSISTOR AND CORRESPONDING FABRICATION METHODS FOR ANGSTROM TECHNOLOGY NODES

      
Application Number 18656915
Status Pending
Filing Date 2024-05-07
First Publication Date 2024-11-21
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Wang, Yeong-Her
  • Hsieh, Chin-Cheng
  • Yang, Chiung-Yi
  • Lu, Darsen Duane
  • Lee, Yao-Jen

Abstract

The proposed L-shaped field effect transistor comprises a horizontal FET and a vertical FET, wherein one end of the former is in contact with one end of the latter. Thus, the gates (or gate channels) of the two FETs can be separated by a distance so as to reduce mutual interference and simplify fabrication. When the two transistors are made of different materials, the contact area therebetween is small and the gates (or gate channels) of the two FETs are separated by a distance. Thus, the negative effect of interface defects close to the contact area can be reduced. To be compared to planar complementary FET (even FinFET and GAAFET), the proposed L-shaped FET can occupy a similar wafer area and have a similar overall thickness after subsequent metallization.

IPC Classes  ?

  • H01L 27/092 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate complementary MIS field-effect transistors
  • H01L 21/8238 - Complementary field-effect transistors, e.g. CMOS
  • H01L 23/528 - Layout of the interconnection structure

50.

POLYPEPTIDE APPLIED TO INHIBITION OF INTRACELLULAR LIPID ACCUMULATION AND SYNTHESIS METHOD THEREOF

      
Application Number 18576106
Status Pending
Filing Date 2022-03-04
First Publication Date 2024-11-07
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Sun, Hungyu
  • Qin, Nong
  • Chuang, Yungchun
  • Cheng, Yuwei
  • Duan, Shuangdi
  • Gao, Yating

Abstract

A biological polypeptide applied to inhibition of intracellular lipid accumulation and a synthesis method thereof are provided. An amino acid sequence of the polypeptide is shown in SEQ ID NO: 1 in sequence listing. The polypeptide has relatively high target affinity and high activity, and can exhibit remarkably high activity at extremely low dosages and concentrations. The polypeptide inhibits binding of clusterin and sterol O-acyltransferase by exerting competition on the clusterin to reduce the activity of the sterol O-acyltransferase, so as to achieve functions of controlling physiological metabolism in organisms, such as relieving lipid accumulation in hepatocytes, resisting tumor occurrence, assisting anti-cancer drugs in inhibiting tumor growth, and the like. A synthesis process of the polypeptide is simple; the molecular weight of the polypeptide is small, and the artificial synthesis efficiency is high; through a solid-phase synthesis method, the difficulty of product purification in each step is greatly reduced.

IPC Classes  ?

  • A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
  • C07K 1/04 - General processes for the preparation of peptides on carriers

51.

PHARMACEUTICAL COMPOSITION FOR TREATING KELOID AND USES THEREOF

      
Application Number 18662966
Status Pending
Filing Date 2024-05-13
First Publication Date 2024-11-07
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor Huang, Lynn L.H.

Abstract

A method of treating a keloid in a subject, comprising: applying a pharmaceutical composition to a keloid or an area at risk of forming a keloid in a subject, wherein the composition includes an effective amount of a hyaluronan and an effective amount of a collagen, the weight ratio per unit volume of the hyaluronan to the collagen being greater than 1.

IPC Classes  ?

  • A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
  • A61K 31/728 - Hyaluronic acid
  • A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

52.

CYCLIC EXPOSURE SCANNING SYSTEM HAVING DISTRIBUTED MULTI-LENS AND METHOD THEREOF

      
Application Number 18619278
Status Pending
Filing Date 2024-03-28
First Publication Date 2024-10-03
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Lee, Yung-Chun
  • Miau, Ting-Hsuan
  • Wu, Chun-Ying

Abstract

The present invention provides a cyclic exposure scanning system having distributed multi-lens and method thereof. The system includes a processor, a platform, an optical engine, a first optical imaging device, a second optical device and a light guide structure. By executing the method of the present disclosure by the system, the optical engine projects the first optical image and the second optical image respectively. The first optical image is guided to the first optical imaging device and the second optical image is sequentially guided to the second optical imaging device through the light guide structure. The first optical imaging device and the second optical imaging device receives and projects the first and second optical images onto the corresponding exposure areas, respectively. Such that efficiency and light source utilization may be significantly increased.

IPC Classes  ?

  • G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

53.

COMMUNICATION METHOD AND COMMUNICATION SYSTEM USING TWO-DIMENSIONAL PRIMARY SYNCHRONIZATION SIGNALS

      
Application Number 18461527
Status Pending
Filing Date 2023-09-06
First Publication Date 2024-09-26
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chen, Chao-Yu
  • Lin, Hsuan-Po
  • Huang, Zhen-Ming

Abstract

A communication method and communication system using two-dimensional primary synchronization signals are provided. The communication system includes a base station and a user equipment. The communication method includes: providing a two-dimensional synchronization array collection having a zero correlation zone; generating plural primary synchronization signals (PSSs) in accordance with the two-dimensional synchronization array collection; generating a synchronization signal block (SSB) in accordance with the primary synchronization signals, in which the synchronization signal block is adapted for new radio (NR) technology, and each one of the primary synchronization signals corresponds to plural orthogonal frequency division multiplexing (OFDM) symbols and plural subcarrier signals; and performing a communication operation by using the synchronization signal block.

IPC Classes  ?

  • H04L 5/00 - Arrangements affording multiple use of the transmission path

54.

COMPOSITIONS AND USES THEREOF IN TREATING CANCERS

      
Application Number 18185630
Status Pending
Filing Date 2023-03-17
First Publication Date 2024-09-19
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Shan, Yan-Shen
  • Chen, Chang-Jung
  • Wang, Hao-Chen

Abstract

Disclosed herein is a composition comprising a lipid nanoparticle and a double-stranded oligodeoxynucleotide (dsODN) encapsulated in the lipid nanoparticle. According to the embodiments of the present disclosure, the dsODN comprises two strands complementary to each other, in which the first strand comprises the nucleotide sequence of SEQ ID NO: 1. Also disclosed herein are methods of treating cancers by using the present composition.

IPC Classes  ?

55.

SEMICONDUCTOR STRUCTURE

      
Application Number 18674953
Status Pending
Filing Date 2024-05-27
First Publication Date 2024-09-19
Owner
  • TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD. (Taiwan, Province of China)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Kung, Te-Ming
  • Wang, Ying-Lang
  • Chen, Kei-Wei
  • Lee, Wen-Hsi
  • Chang, Shu Wei

Abstract

A semiconductor structure includes a substrate, a nanowire disposed over the substrate, a metal gate electrode layer and a gate dielectric layer. A dielectric layer is formed on the substrate. The nanowire has a first portion and a second portion. The nanowire has a first portion and a second portion, the first portion of the nanowire comprises a first semiconductor layer and a second semiconductor layer surrounded by the first semiconductor layer, the second portion comprises the second semiconductor layer. The metal gate electrode layer surrounds the first portion of the nanowire. The gate dielectric layer is disposed between the metal gate electrode layer and the nanowire.

IPC Classes  ?

  • H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
  • H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
  • H01L 21/324 - Thermal treatment for modifying the properties of semiconductor bodies, e.g. annealing, sintering
  • H01L 21/8234 - MIS technology
  • H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched

56.

Method of manufacturing colorful thermal insulation film

      
Application Number 18178825
Grant Number 12163242
Status In Force
Filing Date 2023-03-06
First Publication Date 2024-09-12
Grant Date 2024-12-10
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chung, Chen-Kuei
  • Yu, Chung-Yu
  • Chen, Tsung-Han

Abstract

A method of manufacturing colorful thermal insulation films is provided. A substrate is connected with a metal adhesion layer and then the metal adhesion layer is connected with a porous anodic aluminum oxide (AAO) layer. A porosity of the AAO layer is changed by pore-widening. Thereby the thermal insulation film produced shows the color by the structure color of the AAO layer. Thus no dyes and organic compounds are required to be added during manufacturing process and environmental pollution caused by these substances can be avoided. The pore-widening changes the porosity of the AAO layer and further provides convenient color adjustment so that the colorful thermal insulation film with different colors can be produced easily. Besides providing attractive appearance, the colorful thermal insulation film filters out light with specific wavelengths.

IPC Classes  ?

  • C23C 28/00 - Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of main groups , or by combinations of methods provided for in subclasses and
  • C23C 14/18 - Metallic material, boron or silicon on other inorganic substrates
  • C23C 14/20 - Metallic material, boron or silicon on organic substrates
  • C23C 14/24 - Vacuum evaporation
  • C23C 14/34 - Sputtering
  • C25D 5/54 - Electroplating of non-metallic surfaces
  • C25D 5/56 - Electroplating of non-metallic surfaces of plastics
  • C25D 11/04 - Anodisation of aluminium or alloys based thereon
  • C25D 11/14 - Producing integrally coloured layers
  • C25D 11/16 - Pretreatment
  • C25D 11/18 - After-treatment, e.g. pore-sealing
  • C25D 11/24 - Chemical after-treatment

57.

NEAR-OPTIMAL SCHEDULING SYSTEM FOR CONSIDERING PROCESSING-TIME VARIATIONS AND REAL-TIME DATA STREAMING AND METHOD THEREOF

      
Application Number 18327163
Status Pending
Filing Date 2023-06-01
First Publication Date 2024-09-05
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Tsai, Tsung-Han
  • Yan, Bing
  • Luh, Peter B.
  • Yang, Haw-Ching
  • Bragin, Mikhail A.
  • Cheng, Fan-Tien

Abstract

A near-optimal scheduling system for considering processing-time variations and real-time data streaming includes a data parser module, a publish subscribe mechanism module, a processing time prediction module and a scheduling optimization module. In the processing time prediction module, an orthogonal greedy algorithm and a recurrent neural network are used to extract key features and then predict varying operation processing time. By formulating the scheduling problem in an integer programming form, an ordinal-optimization (OO) embedded decomposition and coordination method is established in the scheduling optimization module to provide dynamic and near-optimal schedules in a computationally efficient manner. Moreover, a publish subscribe mechanism is developed in the publish subscribe mechanism module by using subscribe and publish methods to realize real-time needs. Through this mechanism, the messages (updated production states) are published as specific topics and subscribed by the required modules of a manufacturing execution system without hierarchy delays.

IPC Classes  ?

  • G06Q 10/0631 - Resource planning, allocation, distributing or scheduling for enterprises or organisations
  • G06N 3/0442 - Recurrent networks, e.g. Hopfield networks characterised by memory or gating, e.g. long short-term memory [LSTM] or gated recurrent units [GRU]
  • G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
  • G06Q 50/04 - Manufacturing

58.

CONTACT LENS FOR PHOTODYNAMIC INACTIVATION OF GERMS, PRODUCT AND METHOD OF TREATING FUNGAL KERATITIS BY APPLYING THE SAME

      
Application Number 18506757
Status Pending
Filing Date 2023-11-10
First Publication Date 2024-09-05
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Wong, Tak-Wah
  • Hung, Jia-Horung

Abstract

The present invention is of using contact lenses for photodynamic inactivation of germs, a product, and a method of treating fungal keratitis by applying the same. The contact lens is to continuously release a photoactive solution containing a photosensitizer such as rose bengal and hydrogen peroxide to the ocular surface. The photosensitizer would be activated while these contact lenses are applied and exposed to daylight or other artificial lights in the environment. After activation, the photosensitizer will produce singlet oxygen and reactive oxygen species to inhibit the growth of fungi, thereby treating fungal keratitis without having the patient experiences eye pain or discomfort. Moreover, since the photoactive solution excludes any antifungal agents, the contact lenses for photodynamic inactivation of germs of the present invention can not only improve drug-resistant fungal keratitis but also prevent the germs from developing antimicrobial resistance.

IPC Classes  ?

  • A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
  • A45C 11/00 - Receptacles for purposes not provided for in groups
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 33/40 - Peroxides
  • A61L 12/06 - Radiation, e.g. ultraviolet or microwaves
  • A61P 31/10 - Antimycotics

59.

LEAF VEIN ABSORPTION METHOD AND FUNCTIONAL MODIFICATION MATERIAL FOR PLANT

      
Application Number 18534697
Status Pending
Filing Date 2023-12-10
First Publication Date 2024-08-22
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Yen, Chen-Piao
  • Tu, Sheng-Lung
  • Ting, Jyh-Ming
  • Su, Yen-Hsun

Abstract

Disclosed are a leaf vein absorption method and a functional modification material for plant. The functional modification material has a covering with a functional material and a protector with a polymeric stabilizing material. The functional material is a unitary, a multivariate, or a high-entropy compound, or a semiconducting or an optoelectronic material. The covering covers a surface of a plant organ, wherein the covering comprises a stomata expansion material to enable the functional material to be absorbed into a plant through stomata. The protector covers a surface of the covering. The functional material is capable of maintaining its functional presence on a surface of the plant until the plant organ undergoes natural apoptosis. Through an absorption technology of leaf veins on the surface of the plant, special functions can be achieved without modifying or implanting plant genes.

IPC Classes  ?

  • A01H 1/00 - Processes for modifying genotypes
  • A01H 1/02 - Methods or apparatus for hybridisationArtificial pollination
  • A01N 43/16 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom six-membered rings with oxygen as the ring hetero atom
  • A01N 59/06 - AluminiumCalciumMagnesiumCompounds thereof

60.

CLUSTER-BASED FEDERATED LEARNING BOOKING PLATFORM, BOOKING SYSTEM, AND BOOKING METHOD THEREOF

      
Application Number 18417005
Status Pending
Filing Date 2024-01-19
First Publication Date 2024-08-15
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chung, Pau-Choo
  • Yang, Wei-Jong
  • Chuang, Chao-Chun
  • Chiu, Yen-Jung
  • Wang, Yu-Tai

Abstract

The present invention discloses a federated learning booking platform with a clustered architecture includes a second user end having a dataset and a training end including a main server and a sub-server operated under an assignment from the main server. The main server includes a service server, and the sub-server includes a backup server. The service server is configured to receive the booking information and communicate with the backup server and the first user end based on the booking information. The backup server is configured to store the dataset of the second user end. When the first user end enters the booking information, the first user end trains in synchronization with the backup host. Such that, the training success rate may be significantly improved.

IPC Classes  ?

  • G06Q 10/02 - Reservations, e.g. for tickets, services or events

61.

BLOCK COPOLYPEPTIDES AND USE THEREOF

      
Application Number 18150733
Status Pending
Filing Date 2023-01-05
First Publication Date 2024-07-11
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Jan, Jeng-Shiung
  • Chen, Yu-Fon

Abstract

Provided is a block copolypeptide comprising a first positively charged peptide segment consisting of 5 to 20 substituted or unsubstituted L-lysine, L-arginine, L-ornithine, or L-homoarginine. The block copolypeptide can suppresse the migration and adhesion of cancer cells, reduce tumor growth, and modulate intestinal microbiota, particularly increasing the population of Akkermansia muciniphila. Provided are also a method for treating cancer and a method for increasing the proportion of Akkermansia muciniphila (Akk) in the gut, including administering an effective amount of the block copolypeptide to the subject in need thereof.

IPC Classes  ?

  • C07K 7/00 - Peptides having 5 to 20 amino acids in a fully defined sequenceDerivatives thereof
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 35/00 - Antineoplastic agents

62.

Computing in Memory Accelerator for Applying to a Neural Network

      
Application Number 18118153
Status Pending
Filing Date 2023-03-07
First Publication Date 2024-07-04
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chiou, Lih-Yih
  • Chen, Yun-Ru
  • Chen, Tsung-Chi

Abstract

A computing in memory accelerator for applying to a neural network includes a memory, a data buffer unit, a pooling unit, a loss computing unit, a first macro circuit, a second macro unit, a third macro unit, and a multiplexer. The memory is used for saving data. The data buffer unit is coupled to the memory and used to buffer data outputted from the memory. The pooling unit is coupled to the memory and used to pool data for acquiring a maximum pooling value. The loss computing unit is coupled to the memory and used to compute output loss. The first macro circuit, the second macro unit, and the third macro unit are coupled to the data buffer unit. The multiplexer is coupled to the pooling unit, the first macro circuit, the second macro unit, and the third macro unit and used to generate output data.

IPC Classes  ?

  • G06F 17/16 - Matrix or vector computation
  • G06F 3/06 - Digital input from, or digital output to, record carriers

63.

Fibronectin type III domain-based protein and application thereof

      
Application Number 17977247
Grant Number 12338276
Status In Force
Filing Date 2022-10-31
First Publication Date 2024-06-27
Grant Date 2025-06-24
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Chuang, Woei-Jer

Abstract

The present invention provides a protein, and the protein includes a 10th human fibronectin type III domain and has a first mutation at an amino acid residue with a cysteine residue and a second mutation at another amino acid residue with another cysteine residue, wherein the first mutation and the second mutation take place at a region of the 10th human fibronectin type III domain other than a loop FG so that a disulfide bond is formed between the cysteine residue formed by the first mutation and the cysteine residue formed by the second mutation.

IPC Classes  ?

  • C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
  • A61K 38/00 - Medicinal preparations containing peptides
  • A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

64.

SMART BIO-INSPIRED MATERIAL DESIGN PLATFORM

      
Application Number AU2022051540
Publication Number 2024/130292
Status In Force
Filing Date 2022-12-20
Publication Date 2024-06-27
Owner
  • CHIEN, Chih-Yung (Australia)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Yu, Chi-Hua
  • Tseng, Bor-Yann
  • Chen, Yu-Wen
  • Chen, Chuin-Shan
  • Chan, Tzu-Ching

Abstract

The present invention discloses a smart bio-inspired material design platform to satisfy multi-objective material design featuring complex micro structure for the future. The platform sets mechanical properties of a simulative material element via establishing a reduced model. A distribution of the simulative material element is simulated so as to output a material simulative parameter. A deep learning framework is combined in the platform for computing and evaluating an optimal material design that meets a target material parameter. Specifically, the reduced model can be based on data provided by any test of material mechanical properties, and the deep learning framework evaluates whether a biomimetic material design meets demand of the optimal target material parameter according to a standardized reward function model. The platform is applicable to multi-objective simulative material design, and is greatly potential for futuristic applications.

IPC Classes  ?

  • G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation
  • B33Y 50/00 - Data acquisition or data processing for additive manufacturing
  • G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
  • G05B 19/4099 - Surface or curve machining, making 3D objects, e.g. desktop manufacturing
  • G06F 30/17 - Mechanical parametric or variational design
  • G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
  • G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
  • G06F 113/10 - Additive manufacturing, e.g. 3D printing
  • G06F 113/26 - Composites
  • G06N 3/0464 - Convolutional networks [CNN, ConvNet]

65.

METHOD OF INHIBITING LIPOGENESIS WITH UBIQUITIN-SPECIFIC PEPTIDASE 24 INHIBITOR COMPOSITION

      
Application Number 18498472
Status Pending
Filing Date 2023-10-31
First Publication Date 2024-06-20
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Hung, Chien-Chung

Abstract

The present invention relates to a method of inhibiting lipogenesis with a ubiquitin-specific peptidase 24 (USP24) inhibitor composition. The USP24 inhibitor composition, which includes a carbonyl substituted phenyl compound, can specifically inhibit lipogenesis and hepatic lipid accumulation in a high-fat individual, thereby being applied to a method of inhibiting lipogenesis and hepatic lipid accumulation in a high-fat subject.

IPC Classes  ?

  • A61K 31/5415 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
  • A61P 3/06 - Antihyperlipidemics

66.

METHOD FOR REACTIVE ION ETCHING

      
Application Number 18077171
Status Pending
Filing Date 2022-12-07
First Publication Date 2024-06-13
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Tse-Ming
  • Huang, Chiu-Hua
  • Kao, Ching-Hua
  • Hsieh, Yu-Chiang

Abstract

A method for reactive ion etching includes multiple steps of: (a) placing a film to be etched in a vacuum chamber; (b) introducing an etching gas into the vacuum chamber; (c) starting a reactive ion etching to etch the film via the etching gas in a first duration; (d) in a second duration, stopping reactive ion etching and extracting the remaining gas in the vacuum chamber to make the vacuum chamber be in a high-clean state; and (e) repeating step (b) to (d) until an etching depth of the film is reached to a predetermined value.

IPC Classes  ?

  • C09K 13/08 - Etching, surface-brightening or pickling compositions containing an inorganic acid containing a fluorine compound

67.

WATER-SOLUBLE PHOTOSENSITIVE COMPOSITION OF PHOTODYNAMIC ENVIRONMENTAL DISINFECTION AND METHOD OF ENVIRONMENTAL DISINFECTION BY USING THE SAME

      
Application Number 18351532
Status Pending
Filing Date 2023-07-13
First Publication Date 2024-06-06
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Wong, Tak-Wah
  • Yu, Chun-Keung
  • Lin, Ming-Yeng

Abstract

The present invention is appertaining to a water-soluble photosensitive composition of photodynamic environmental disinfection and method of environmental disinfection by using the same. In this method, a short-term atomization step and a white light irradiation step with a low light dose are performed on the water-soluble photosensitive composition composed of water, low-concentration methylene blue and hydrogen peroxide to obtain photoactivated atomized particles, which can be performed in a sequential or simultaneous manner. The obtained photoactivated atomized particles can effectively inhibit the pathogenicity and/or the infectivity of viruses in the environment, and therefore, be applied to the method of photodynamic environmental disinfection.

IPC Classes  ?

  • A61L 2/22 - Phase substances, e.g. smokes, aerosols
  • A61L 9/14 - Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances

68.

METHODS FOR TREATING CANCERS BY USING NANOFRAMES OF PRUSSIAN BLUE OR AN ANALOGUE THEREOF AND ITS PRODUCTION METHODS

      
Application Number 18073612
Status Pending
Filing Date 2022-12-02
First Publication Date 2024-06-06
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Yeh, Chen-Sheng
  • Li, Wei-Peng
  • Wang, Liu-Chun

Abstract

Disclosed herein is drawn to a method for producing a nanoframe of Prussian blue (PB) or an analogue thereof (PBA). The producing method comprises: (a) mixing a nanocube of PB or PBA with an acid solution to form a mixture; and (b) heating the mixture of the step (a) in an oil bath at 80-100° C. for 0.5 hours-1 month to produce the nanoframe of PB or PBA. Also encompassed herein is a method for treating a cancer in a subject in need thereof, which comprises administering an effective amount of a nanocube or a nanoframe of PB or PBA to the subject.

IPC Classes  ?

  • A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
  • A61K 33/26 - IronCompounds thereof
  • A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 35/00 - Antineoplastic agents

69.

SOLID-STATE POLYMER ELECTROLYTE FOR LITHIUM BATTERY

      
Application Number 18528829
Status Pending
Filing Date 2023-12-05
First Publication Date 2024-06-06
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Teng, Hsisheng
  • Nguyen, Thi Tuyet Hanh
  • Nguyen, Le Minh
  • Wu, Wen-Hsiang
  • Lin, Yu-Hsing

Abstract

A solid-state polymer electrolyte for lithium batteries is provided. The solid-state polymer electrolyte includes a solid-state network polymer electrolyte, formed by a modified poly(ethylene oxide) polymer material and an epoxy alkane crosslinking agent to form a poly(ethylene oxide) network structure, wherein the modified poly(ethylene oxide) high molecular weight material has an amino end, and the solid-state network polymer electrolyte comprises a lithium salt, The ratio of ethylene oxide (EO) to lithium (Li) in the solid-state network polymer electrolyte is 1:1 to 3:1, and a poly(vinylidene fluoride)-based polymer is doped in the solid-state network polymer electrolyte.

IPC Classes  ?

  • H01M 10/0565 - Polymeric materials, e.g. gel-type or solid-type
  • H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
  • H01M 10/052 - Li-accumulators
  • H01M 10/0568 - Liquid materials characterised by the solutes

70.

HEARING AIDING APPARATUS INTEGRATING IMAGE-ACOUSTICS POSITIONING, OMNIDIRECTIONAL ACOUSTIC RECEPTION, AND WARNING

      
Application Number 18337820
Status Pending
Filing Date 2023-06-20
First Publication Date 2024-05-30
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Du, Yi-Chun

Abstract

A hearing aiding apparatus integrating image-acoustics positioning, omnidirectional acoustic reception, and warning includes an apparatus body, an acoustic-receiving unit, an image-capturing unit, a warning device, and a control unit. The apparatus body has a playing unit. The acoustic-receiving unit captures audio signals around the apparatus body in a 360-degree range. The audio signals include ambient sounds and speaking voices. The image-capturing unit captures human-face images around the apparatus body. The control unit stores human-face images, speaking voices, and special ambient sound audios. The control unit receives the audio signals and the human-face images and uses computer vision to identify and enhance the speaking voices associated with the human-face images. Then the playing unit plays the speaking voices. The control unit issues a warning message via the warning device when receiving an ambient sound identical to a pre-stored special ambient sound.

IPC Classes  ?

  • G08B 21/18 - Status alarms
  • G06V 40/16 - Human faces, e.g. facial parts, sketches or expressions
  • G10L 25/51 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination
  • H04N 23/57 - Mechanical or electrical details of cameras or camera modules specially adapted for being embedded in other devices
  • H04N 23/611 - Control of cameras or camera modules based on recognised objects where the recognised objects include parts of the human body
  • H04N 23/67 - Focus control based on electronic image sensor signals
  • H04N 23/90 - Arrangement of cameras or camera modules, e.g. multiple cameras in TV studios or sports stadiums
  • H04R 25/00 - Deaf-aid sets

71.

METHOD OF PRODUCING A MEDICAL IMPLANT ADOPTING ADDITIVE MANUFACTURING

      
Application Number 18518644
Status Pending
Filing Date 2023-11-24
First Publication Date 2024-05-30
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Yeh, Ming-Long
  • Wu, Guan-Lin
  • Yen, Chin-En
  • Feng, Ching

Abstract

The present invention discloses a method of producing a medical implant adopting additive manufacturing including: distributing magnesium-zinc-zirconium alloy powder on a substrate to form a powder layer; generating a high-energy beam within a specific power range and directing the high-energy beam to the powder layer through a probe to sinter a region of the powder layer; distributing the plurality of magnesium-zinc-zirconium alloy powder on the sintered region of the powder layer; and repeating above steps until the medical implant is formed.

IPC Classes  ?

  • B22F 12/41 - Radiation means characterised by the type, e.g. laser or electron beam
  • B22F 10/64 - Treatment of workpieces or articles after build-up by thermal means

72.

METAL ELECTRODE OF CERAMIC CAPACITOR AND METHOD OF FORMING THE SAME

      
Application Number 18173799
Status Pending
Filing Date 2023-02-24
First Publication Date 2024-05-23
Owner
  • YAGEO CORPORATION (Taiwan, Province of China)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Hsiang, Hsing-I
  • Yen, Fu-Su
  • Huang, Chi-Yuen
  • Lee, Chun-Te
  • Yang, Kai-Hsun
  • Wang, Shih-Ming

Abstract

A metal electrode of a ceramic capacitor and a method of forming the same are provided. The method includes mixing metal powders and a barium titanate organic-precursor to obtain precursor powders; adding an adhesive to the precursor powders to obtain a metal slurry; performing a molding process to the metal slurry to obtain a film material; performing a binder burn-out process to the film material to obtain a degumming film; and performing a sintering process to the degumming film to obtain the metal electrode. By mixing specific amount of barium titanate organic-precursor with the metal powders, the barium titanate metallic organic-precursor can be transformed to barium titanate in the following process, and barium titanate can be dispersed between the metals homogeneously. Therefore, electrode continuity can be increased.

IPC Classes  ?

73.

Level-shifting amplifier with gain error reduction

      
Application Number 17991809
Status Pending
Filing Date 2022-11-21
First Publication Date 2024-05-23
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Wang, Jia-Ching
  • Kuo, Tai-Haur

Abstract

An amplifier circuit includes an input terminal, configured to receive an input voltage; an output terminal, configured to output an output voltage; a multi-stage operational amplifier, coupled to the input terminal and the output terminal, and configured to amplify the input voltage to the output voltage, comprising a plurality of amplifiers; and a plurality of level-shifting networks, each coupled between two of the plurality of amplifiers, configured to reduce a gain error of each output of the plurality of amplifiers; and a feedback capacitor, coupled between the input terminal and the output terminal.

IPC Classes  ?

  • H03F 1/32 - Modifications of amplifiers to reduce non-linear distortion

74.

Ternary prussian blue analogue and method of preparing the same

      
Application Number 18058409
Grant Number 12128385
Status In Force
Filing Date 2022-11-23
First Publication Date 2024-05-23
Grant Date 2024-10-29
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Ting, Jyh-Ming
  • Yang, Kai-Hasiang

Abstract

3 and represented by the Formula (1) as defined herein, and can be used as a catalyst for oxygen evolution reaction. The method includes separately dissolving transition metal salts, ferrocyanide of alkali metals, and alkali metal salts in different solutions; adding the first two solutions to the third solution; mixing; precipitating; and drying. The ternary Prussian blue analogue catalyst is prepared by a simple and low-energy-consuming co-precipitation method, and the ternary Prussian blue analogue exhibit excellent electrocatalytic property through the synergistic effect of multiple transition metals.

IPC Classes  ?

  • B01J 23/04 - Alkali metals
  • B01J 23/22 - Vanadium
  • B01J 23/26 - Chromium
  • B01J 23/745 - Iron
  • B01J 23/75 - Cobalt
  • B01J 23/755 - Nickel
  • B01J 23/78 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with alkali- or alkaline earth metals or beryllium
  • B01J 23/847 - Vanadium, niobium or tantalum
  • B01J 23/86 - Chromium
  • B01J 27/26 - Cyanides
  • B01J 35/30 - Catalysts, in general, characterised by their form or physical properties characterised by their physical properties
  • B01J 35/39 - Photocatalytic properties
  • B01J 35/40 - Catalysts, in general, characterised by their form or physical properties characterised by dimensions, e.g. grain size
  • B01J 35/64 - Pore diameter
  • B01J 37/02 - Impregnation, coating or precipitation
  • B01J 37/03 - PrecipitationCo-precipitation
  • B01J 37/04 - Mixing
  • B01J 37/08 - Heat treatment

75.

CATALYST FOR FUEL CELLS AND METHODS OF PREPARING THE SAME

      
Application Number 18058979
Status Pending
Filing Date 2022-11-28
First Publication Date 2024-05-23
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Ting, Jyh-Ming
  • Wei, Zi-Yun

Abstract

The present disclosure provides a catalyst for urea oxidation reaction, a method of preparing the same, and a use thereof. The catalyst for urea oxidation reaction includes transition metal oxides forming on a metal substrate, and the transition metals includes Fe, Co, and Ni. The method for preparing the catalyst includes contacting the metal substrate with a homogeneous solution to obtain the catalyst for urea oxidation reaction, and the homogeneous solution includes transition metal nitrate precursors and a sulfur precursor. The method of the present application is a low-cost, high-efficiency, and simple process that can be mass produced.

IPC Classes  ?

  • H01M 4/90 - Selection of catalytic material
  • H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
  • H01M 4/88 - Processes of manufacture

76.

ELECTRODE STRUCTURE AND ITS MANUFACTURING METHOD AND BATTERY STRUCTURE INCLUDING THE SAME

      
Application Number 18510995
Status Pending
Filing Date 2023-11-16
First Publication Date 2024-05-23
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Fung, Kuan-Zong
  • Tsai, Shu-Yi

Abstract

An electrode structure used for a solid-state battery comprises a conductive structure and an electrode material, wherein the conductive structure comprises a conductor and a plurality of continuous pores formed on the conductor, and the conductor exhibits both of electronic conduction and ionic conduction materials. The electrode material comprises a plurality of active material particles, which are used to fill the continuous pores and in electrical contact with each other to form an electrical connection with the conductive structure. The manufacturing method of the electrode structure and its application in the battery structure are also disclosed.

IPC Classes  ?

  • H01M 4/80 - Porous plates, e.g. sintered carriers
  • H01M 4/02 - Electrodes composed of, or comprising, active material

77.

Non-volatile static random access memory

      
Application Number 18087279
Grant Number 12224008
Status In Force
Filing Date 2022-12-22
First Publication Date 2024-05-23
Grant Date 2025-02-11
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Lu, Darsen Duane
  • Baig, Mohammed Aftab
  • Huang, Siao-Shan
  • Chang, Fu Yuan

Abstract

A non-volatile static random access memory includes: a static random access memory, a reading element and a first embedded non-volatile memory. The static random access memory includes a first inverter, a second inverter and two transistors, an output terminal of the first inverter and the input terminal of the second inverter are electrically connected to each other to serve as a Q node, an input terminal of the first inverter and an output terminal of the second inverter are electrically connected to each other to serve as a QB node, and the two transistors are electrically connected to the Q node and the QB node, respectively. The reading element is electrically connected to the Q node. The first embedded non-volatile memory is electrically connected to the QB node.

IPC Classes  ?

  • G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements
  • G06F 3/06 - Digital input from, or digital output to, record carriers
  • G11C 14/00 - Digital stores characterised by arrangements of cells having volatile and non-volatile storage properties for back-up when the power is down

78.

ARTIFICIAL TANZANITE AND ITS MANUFACTURING METHOD

      
Application Number 17985282
Status Pending
Filing Date 2022-11-11
First Publication Date 2024-05-16
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chen, Yen-Hua
  • Ni, Jia-Cheng

Abstract

An artificial tanzanite comprises aluminosilicate and vanadium, wherein the content of the aluminosilicate is in a range from 1 mass % to 30 mass % and the content of the vanadium is in a range from 1000 ppm to 40000 ppm. The artificial tanzanite is prepared by a method comprising: providing a synthetic raw material, wherein the synthetic raw material comprises the aluminosilicate, silicon-containing oxide, vanadium-containing oxide, and calcium-containing salt; and heating the synthetic raw material to a synthetic temperature, and keeping the synthetic raw material under a synthetic pressure to carry out synthetic reaction to form the artificial tanzanite after a period of synthetic time.

IPC Classes  ?

79.

FUNCTIONAL POWDER DELIVERY DEVICE AND SYSTEM THEREOF

      
Application Number 17988041
Status Pending
Filing Date 2022-11-16
First Publication Date 2024-05-16
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Lin, Xi-Zhang
  • Shih, Ya-Wen
  • Hwang, Sheng-Jye

Abstract

The present invention discloses a functional powder delivery device for precise locating and quantifying when delivering the functional powder to a site in need in a patient. Meanwhile, the device avoids negative pressure effect in the output catheter when airflow is switched, and thus prevents pollution or jam in the output catheter due to splash or back flow of body fluid. The device ensures tube clearance of the output catheter by maintaining continuous airflow, and a special design of airflow switch allows switching to airflow of large volume to carry the powder when required. Through continuous positive airflow in the tube system, the functional powder can be delivered to the site in need by a continuous powder flow, which overcomes drawbacks of the delivery devices in prior arts. In addition, the design of foot pedal can help endoscopist for a solo operation. The serial connecting parts can adapt for various size of bottles of various types of functional powder.

IPC Classes  ?

  • A61M 16/06 - Respiratory or anaesthetic masks
  • A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
  • A61M 16/08 - BellowsConnecting tubes
  • A61M 16/20 - Valves specially adapted to medical respiratory devices

80.

SYSTEM AND METHOD OF GENERATING KNOWLEDGE GRAPH AND SYSTEM AND METHOD OF USING THEREOF

      
Application Number 17986782
Status Pending
Filing Date 2022-11-14
First Publication Date 2024-05-02
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Lu, Wen-Hsiang
  • Tung, Chia-Ming
  • Liou, Ding-Jhe

Abstract

A method of generating knowledge graph, performed by a processing device, includes: obtaining a knowledge document, performing word segmentation and part-of-speech tagging on the knowledge document to generate a number of tagged words, obtaining a number of sentences from the tagged words according to a default sentence pattern, wherein each of the sentences includes a subject, an adverb, a verb and an object, and the adverb corresponding to an adverb type, for each of the sentences, performing: using the subject as a first entity of a triple, using the object as a second entity of the triple, and using the adverb type and the verb as a relation in the triple, and forming a knowledge graph using the triple corresponding to each of the sentences.

IPC Classes  ?

  • G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates
  • G06F 40/117 - TaggingMarking up Designating a blockSetting of attributes
  • G06F 40/253 - Grammatical analysisStyle critique
  • G06F 40/35 - Discourse or dialogue representation
  • G06N 5/02 - Knowledge representationSymbolic representation

81.

CATALYST FOR OER/ORR AND METHODS OF PREPARING THE SAME

      
Application Number 18054480
Status Pending
Filing Date 2022-11-10
First Publication Date 2024-05-02
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Ting, Jyh-Ming
  • Lin, Kai-Wei

Abstract

Provided a catalyst for OER/ORR, including: an alloy oxide core having a particle size of 30 to 40 nm; and a carbon layer having a thickness of 1 to 7 nm, which is coated on a surface of the alloy oxide core, wherein the alloy oxide is a ternary to quinary alloy oxide, and the metal element contained in the alloy oxide is a transition metal element. Also provided is a method for preparing catalysts for OER/ORR by an electrospinning process. Accordingly, the prepared catalyst has excellent OER and ORR characteristics.

IPC Classes  ?

  • H01M 4/90 - Selection of catalytic material
  • C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
  • D01D 1/02 - Preparation of spinning solutions
  • D01D 5/00 - Formation of filaments, threads, or the like
  • D01F 9/08 - Man-made filaments or the like of other substancesManufacture thereofApparatus specially adapted for the manufacture of carbon filaments of inorganic material
  • H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
  • H01M 4/96 - Carbon-based electrodes

82.

CORE-SHELL CATHODE AND A LITHIUM-SULFUR BATTERY USING THE SAME

      
Application Number 18088069
Status Pending
Filing Date 2022-12-23
First Publication Date 2024-05-02
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chung, Sheng-Heng
  • Wu, Yun-Chen

Abstract

The present invention provides a core-shell cathode characterized by comprising: a shell comprising an electrically conductive, porous carbon material; and a core, which is an inner cavity enclosed within the shell, wherein the core contains an active material and an electrolyte, and the active material comprises liquid polysulfide having the general formula Li2Sx, wherein 4≤x≤8; the shell comprises a first layer, an O-ring and a second layer sequentially stacked from bottom to top to form the inner cavity to contain the active material and the electrolyte. The present invention also provides a lithium-sulfur battery using said core-shell cathode, which attains both high sulfur loading and high sulfur content, and simultaneously satisfies high energy density, high capacity retention and high cycle stability under lean-electrolyte condition.

IPC Classes  ?

  • H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
  • H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
  • H01M 10/052 - Li-accumulators

83.

EXAMINATION SYSTEM AND EXAMINATION METHOD THEREOF

      
Application Number 18404746
Status Pending
Filing Date 2024-01-04
First Publication Date 2024-05-02
Owner
  • DELTA ELECTRONICS, INC. (Taiwan, Province of China)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chen, Chih-Yang
  • Chung Chan, Pau-Choo
  • Tseng, Sheng-Hao

Abstract

An examination system is provided. The examination system includes an optical detector and analyzer. The optical detector emits a detection light source toward a target object and detects a respondent light which is induced from the target object in response to the detection light source to generate image data. The image data indicates a detection image. The analyzer receives the image data and determines which region of the target object the detection image belongs to according to the image data. When the analyzer determines that the detection image belongs to a specific region of the target object, the analyzer extracts at least one feature of the image data to serve as a basis for classification of the specific region.

IPC Classes  ?

  • G06V 30/142 - Image acquisition using hand-held instrumentsConstructional details of the instruments
  • A61B 5/00 - Measuring for diagnostic purposes Identification of persons
  • G06F 18/2433 - Single-class perspective, e.g. one-against-all classificationNovelty detectionOutlier detection
  • G06T 7/00 - Image analysis
  • G06T 7/11 - Region-based segmentation
  • G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
  • G06V 10/54 - Extraction of image or video features relating to texture
  • G06V 10/72 - Data preparation, e.g. statistical preprocessing of image or video features
  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

84.

HOT-PRESSED CARBON/SULFUR COMPOSITE ENERGY-STORAGE CATHODE, A METHOD OF MANUFACTURING THE CATHODE, AND THE LITHIUM-SULFUR BATTERY USING THE SAME

      
Application Number 18088241
Status Pending
Filing Date 2022-12-23
First Publication Date 2024-05-02
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chung, Sheng-Heng
  • Wu, Cheng-Che

Abstract

The present invention provides a hot-pressed carbon/sulfur composite energy-storage cathode utilized in a lithium-sulfur battery, comprising: a conductive porous substrate with specific surface area of 1˜100 m2/g before sulfur loading, and a sulfur layer formed on the conductive porous substrate by hot-pressing method; the cathode has a sulfur loading of 8 mg/cm2 and a sulfur content of 73 wt %. The lithium-sulfur battery of the present invention, with the significant enhancement of the loading and the content of the active material achieved by the hot-pressed carbon/sulfur composite energy-storage cathode, may have the effect of high cyclability and high energy density in a lean-electrolyte lithium-sulfur battery with a low electrolyte-to-sulfur ratio of 7˜4 μL/mg.

IPC Classes  ?

  • H01M 4/04 - Processes of manufacture in general
  • H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
  • H01M 4/66 - Selection of materials
  • H01M 10/052 - Li-accumulators

85.

BIOMASS TREATMENT METHOD, BIOCHAR AND COMPOSITE MATERIAL

      
Application Number 18118712
Status Pending
Filing Date 2023-03-07
First Publication Date 2024-04-18
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Chen, Wei-Hsin
  • Lee, Kuan-Ting

Abstract

A biomass treatment method includes steps as follows. A biomass and sodium percarbonate are provided, wherein the biomass includes hemicellulose, cellulose and/or lignin. The biomass and the sodium percarbonate are mixed.

IPC Classes  ?

  • C09C 1/44 - Carbon
  • C04B 14/02 - Granular materials
  • C08K 3/04 - Carbon
  • C09D 7/61 - Additives non-macromolecular inorganic
  • C10B 53/02 - Destructive distillation, specially adapted for particular solid raw materials or solid raw materials in special form of cellulose-containing material
  • C10B 57/06 - Other carbonising or coking processesFeatures of destructive distillation processes in general using charges of special composition containing additives
  • C10B 57/14 - Features of low-temperature carbonising processes

86.

QUANTUM CIRCUIT OF COIFLET C6 WAVELET TRANSFORM AND INVERSE TRANSFORM AND MANUFACTURING METHOD THEREOF

      
Application Number 17988676
Status Pending
Filing Date 2022-11-16
First Publication Date 2024-04-18
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Hwang, Chi-Chuan

Abstract

A quantum circuit of Coiflet'C6 wavelet transform includes a B quantum circuit, a Q2n·Q2n quantum circuit, and an A quantum circuit. The B quantum circuit is configured to receive a first part of data of n-dimension and generate a first intermediate result. The Q2n·Q2n quantum circuit is configured to receive a second part of the data and generate a first result. The Q2n·Q2n quantum circuit is coupled to the B quantum circuit to receive the first intermediate result and generate a second intermediate result. The A quantum circuit is coupled to the Q2n·Q2n quantum circuit to receive the second intermediate result and generate a second result. The present disclosure also proposes a manufacturing method of a Coiflet'C6 wavelet transform quantum circuit and a Coiflet'C6 wavelet inverse transform quantum circuit.

IPC Classes  ?

  • G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
  • G06F 17/16 - Matrix or vector computation

87.

MAGNETIC MULTI-POLE PROPULSION ARRAY SYSTEM

      
Application Number 18084519
Status Pending
Filing Date 2022-12-19
First Publication Date 2024-04-18
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Li, Yueh-Heng
  • Wu, Yu-Ting
  • Huang, Chao-Wei
  • Lo, Wei-Cheng
  • Hsieh, Hsun-Chen
  • Huang, Ping-Han
  • Huang, Yi-Long
  • Liu, Sheng-Wen
  • Lien, Wei-Cheng

Abstract

A magnetic multi-pole propulsion array system is applied to at least one external cathode and includes a plurality of magnetic multi-pole thrusters connected adjacent to each other. Each magnetic multi-pole thruster includes a propellant provider, a discharge chamber, an anode and a plurality of magnetic components. The propellant provider outputs propellant. The discharge chamber is connected with the propellant provider to accommodate the propellant. The anode is disposed inside the discharge chamber to generate an electric field. The plurality of magnetic components is respectively disposed on several sides of the discharge chamber. One of the several sides of the discharge chamber of the magnetic multi-pole thruster is applied for one side of a discharge chamber of another magnetic multi-pole thruster.

IPC Classes  ?

  • B64G 1/40 - Arrangements or adaptations of propulsion systems
  • H02N 11/00 - Generators or motors not provided for elsewhereAlleged perpetua mobilia obtained by electric or magnetic means

88.

SMART SENSORIZED GRIPPER

      
Application Number 17952803
Status Pending
Filing Date 2022-09-26
First Publication Date 2024-04-04
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor Lan, Chao-Chieh

Abstract

A smart sensorized gripper connected to and controlled by a controlling device comprises a gripper base, a driving assembly, two moving assemblies, two gripping assemblies, two angle sensors and a displacement sensor. The driving assembly and the sensors are disposed on the gripper base and connected to the controlling device. The driving assembly drives the gripping assemblies to grip and release an object through the moving assemblies. An axial force along a Z-direction and a gripping force along an X-direction of the smart sensorized gripper are controlled by sensing crank elements of the gripping assemblies with the angle sensors and sensing a displacement of a moving element of the driving assembly with the displacement sensor, increasing functionality and positioning precision. The sensors are disposed at the gripper base to avoid extra electrical wirings on the gripping assemblies, simplifying the wirings and reducing the cost.

IPC Classes  ?

  • B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
  • B25J 9/16 - Programme controls

89.

Test Strip Carrier, System and Method for Test Strip Detection

      
Application Number 17985909
Status Pending
Filing Date 2022-11-14
First Publication Date 2024-03-28
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Lin, Yu-Cheng
  • Weng, Wei-Chien
  • Chen, Yi-Hsuan

Abstract

A test strip detecting system includes a test strip, a test strip detecting carrier and a mobile communication apparatus. The test strip detecting carrier includes a container structure, positioning markers and colorimetric calibrating blocks, and the colorimetric calibrating blocks are embedded inside the positioning markers. The test strip is placed in the container structure and reacts with a specimen to generate color blocks. The mobile communication apparatus controls an image capture unit to capture an original image of the test strip placed in the test strip detecting carrier; detects the positioning markers in the original image to obtain a plurality of coordinates of the positioning markers; performs image coordinate calibration according to the plurality of coordinates to generate a calibrated image; and performs a colorimetric calibration for the color blocks and the colorimetric calibrating blocks according to the calibrated image so as to generate a test result.

IPC Classes  ?

  • G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
  • G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
  • G01N 21/84 - Systems specially adapted for particular applications
  • G06T 7/90 - Determination of colour characteristics

90.

HYBRID SYSTEM AND METHOD FOR DISTRIBUTED VIRTUAL POWER PLANTS INTEGRATED INTELLIGENT NET ZERO

      
Application Number 18051521
Status Pending
Filing Date 2022-11-01
First Publication Date 2024-03-21
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Ou, Ting-Chia
  • Tieng, Hao
  • Cheng, Fan-Tien
  • Tsai, Tsung-Han
  • Li, Yu-Yong

Abstract

Embodiments of the present invention provide a hybrid system and method for distributed virtual power plants integrated intelligent net zero. In this method, a cyber physical agent (CPA) is utilized to collect a carbon emission information and an energy management information, and then an artificial intelligence (AI) optimization model of an intelligent central dispatch platform is utilized to obtain a power dispatch manner of the distributed virtual power plants based on the carbon emission information and the energy management information, such that the power dispatch manner of the distributed virtual power plants meets the requirements of enterprise economic benefits and net zero carbon emissions at the same time.

IPC Classes  ?

  • H02J 3/00 - Circuit arrangements for ac mains or ac distribution networks
  • G06Q 40/04 - Trading Exchange, e.g. stocks, commodities, derivatives or currency exchange

91.

HYBRID SYSTEM AND METHOD OF CARBON AND ENERGY MANAGEMENTS FOR GREEN INTELLIGENT MANUFACTURING

      
Application Number 18051525
Status Pending
Filing Date 2022-11-01
First Publication Date 2024-03-21
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Tieng, Hao
  • Cheng, Fan-Tien
  • Ou, Ting-Chia
  • Tsai, Tsung-Han
  • Li, Yu-Yong

Abstract

A hybrid method for green intelligent manufacturing (GiM) combines the carbon reduction and the energy saving into the intelligent manufacturing based Industry 4.1 cloud platform. GiM assists companies to achieve the goal of net zero transition and help them advance to Industry 4.2 as soon as possible by simultaneously taking carbon footprint and energy issues into account. GiM collects large volumes of essential data (including carbon footprint) via cyber physical agents (CPAs), and sends them to two critical services of carbon management and intelligent energy management system (iEMS) deployed on the cloud platform. The two critical services optimize the energy dispatch schedule by strictly following the requirements of energy saving, carbon reduction, and net zero. Then, the state of zero defects of intelligent manufacturing achieved in Industry 4.1 can be upgraded to net zero of GiM in Industry 4.2.

IPC Classes  ?

92.

HAND TRAINING METHOD WITH FORCE FEEDBACK AND HAND TRAINING DEVICE

      
Application Number 18370431
Status Pending
Filing Date 2023-09-20
First Publication Date 2024-03-21
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Su, Fong-Chin
  • Kuo, Li-Chieh
  • Chieh, Hsiao-Feng
  • Lin, Chien-Ju
  • Hsu, Hsiu-Yun

Abstract

The present invention discloses a force feedback hand training method including: providing a training game content and adjusting the training game content based on predetermined parameters; displaying the training game content on a display; determining whether an input button position of at least one input signal from a hand training device matches a predetermined input button position; and storing a determination result in a storage module.

IPC Classes  ?

  • A63F 13/24 - Constructional details thereof, e.g. game controllers with detachable joystick handles
  • A63F 13/218 - Input arrangements for video game devices characterised by their sensors, purposes or types using pressure sensors, e.g. generating a signal proportional to the pressure applied by the player
  • A63F 13/22 - Setup operations, e.g. calibration, key configuration or button assignment
  • A63F 13/285 - Generating tactile feedback signals via the game input device, e.g. force feedback

93.

FUSION PROTEIN CONTAINING TISSUE PLASMINOGEN ACTIVATOR OR ITS VARIANT AND TARGETING INTEGRIN ALPHA(IIB)BETA(3) AND THE APPLICATION THEREOF

      
Application Number 17978532
Status Pending
Filing Date 2022-11-01
First Publication Date 2024-03-14
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor Chuang, Woei-Jer

Abstract

The present invention provides a fusion protein, which includes: (a) a tissue plasminogen activator or a variant thereof; (b) a disintegrin or a variant thereof; and (c) a linker positioned between the tissue plasminogen activator or the variant thereof and the disintegrin or the variant thereof and the linker having an amino acid sequence selected from SEQ ID Nos.: 1-7. The present invention also provides a method for treating or preventing a disease related to thrombosis by using the foregoing fusion protein.

IPC Classes  ?

  • C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
  • A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
  • C07K 14/46 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates

94.

BIOMARKER FOR EARLY DETECTION OF ALZHEIMER DISEASE

      
Application Number 18351583
Status Pending
Filing Date 2023-07-13
First Publication Date 2024-03-07
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Lee, Gwo-Giun
  • Kung, Te-Han
  • Chao, Tzu-Cheng
  • Kuo, Yu-Min

Abstract

The present disclosure relates to a method for providing biomarker for early detection of Alzheimer's Disease (AD), and particularly to a method that is able to enhance the accuracy of predicting AD from Mild Cognitive Impairment (MCI) patients using the Hippocampus magnetic resonance imaging (MRI) scans and Mini-Mental State Examination (MMSE) data. The providing MRI images containing the anatomical structure of Hippocampus biomarker and MMSE data as a training data set; training a processor using the training data set, and the training comprising acts of receiving MRI images and MMSE data as a testing data set from a target; and classifying the test data by the trained processor to include aggregating predictions.

IPC Classes  ?

  • G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
  • G06N 3/08 - Learning methods

95.

Optical measurement system

      
Application Number 17894164
Grant Number 12196550
Status In Force
Filing Date 2022-08-24
First Publication Date 2024-02-01
Grant Date 2025-01-14
Owner National Cheng-Kung University (Taiwan, Province of China)
Inventor
  • Liu, Chien-Sheng
  • Shih, Wen-Yu

Abstract

An optical measurement system measuring optical parameters of an object is provided. The object includes at least two light-transmitting layers. The optical measurement system includes a light source module, an image capture module, and a controller. The light source module emits at least two measurement light beams toward the object. The measurement light beams are respectively incident on the object at different angles. The image capture module receives light spots formed on a sensing surface of the image capture module by at least two first light beams after the measurement light beams are reflected by the object and at least two second light beams after the measurement light beams are refracted and reflected between the object. The controller is electrically connected to the image capture module to obtain positions of the light spots. The controller calculates the optical parameters of the object according to the positions of the light spots.

IPC Classes  ?

  • G01B 9/02015 - Interferometers characterised by the beam path configuration
  • G01B 11/06 - Measuring arrangements characterised by the use of optical techniques for measuring length, width, or thickness for measuring thickness
  • G01B 11/26 - Measuring arrangements characterised by the use of optical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of optical techniques for testing the alignment of axes
  • G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length

96.

REHABILITATION DEVICE

      
Application Number 18208239
Status Pending
Filing Date 2023-06-09
First Publication Date 2024-02-01
Owner National Cheng Kung University (Taiwan, Province of China)
Inventor
  • Kuo, Yao-Lung
  • Chang, Chih-Han
  • Kuo, Li-Chieh
  • Yang, Kang-Chin
  • Lin, Yu-Chen
  • Chuang, Ping-Han

Abstract

A rehabilitation device includes a base unit, a circuit unit, a rolling unit, and a holding unit. The circuit unit includes a distance measuring element, which is partially exposed on a bottom surface of the base unit and can measure the moving distance of the base unit after the base unit contacts a plane. The rolling unit includes a plurality of rollers partially protruding from the base unit, a driving member, and at least one auxiliary wheel driven by the driving member. The rollers are continuously in contact with the plane, and the auxiliary wheel is driven to contact the plane. The rollers can make the base unit slide, allowing the user to stretch their upper limbs by themselves. When the user moves to his own limit position, the auxiliary wheel can be driven to gradually increase the moving distance of the base unit, so that the upper limb can be continuously stretched, and the limit of the extension distance and joint movement angle of the upper limb can be gradually increased.

IPC Classes  ?

  • A61H 15/00 - Massage by means of rollers, balls, e.g. inflatable, chains, or roller chains

97.

ELECTRICAL NERVE STIMULATION

      
Application Number 18227791
Status Pending
Filing Date 2023-07-28
First Publication Date 2024-02-01
Owner
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
  • The Regents of the University of California (USA)
Inventor
  • Hsueh, Yuan-Yu
  • Liu, Wentai
  • Chen, Szu Han
  • Tseng, Wan-Ling
  • Lin, Chun-Wei

Abstract

A nerve stimulation system includes an electrode, an electrode controlling device coupled to the electrode and configured to control the electrode to electrically stimulate a peripheral nerve according to a nerve stimulation signal, and a signal generating device coupled to the electrode controlling device and configured to generate the nerve stimulation signal. The nerve stimulation signal is a signal with a square envelope. The square envelope periodically includes an on-time period with a pulse amplitude and an off-time period without the pulse amplitude, and a ratio of the on-time period and the off-time period is not less than 1, and a length of the off-time period is not longer than 5 seconds.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

98.

Sweep voltage generator and display panel

      
Application Number 18078092
Grant Number 11967272
Status In Force
Filing Date 2022-12-09
First Publication Date 2024-01-25
Grant Date 2024-04-23
Owner
  • AUO Corporation (Taiwan, Province of China)
  • National Cheng-Kung University (Taiwan, Province of China)
Inventor
  • Lin, Chih-Lung
  • Huang, Yi-Chen
  • Liu, Chih-I
  • Lai, Po-Cheng
  • Deng, Ming-Yang
  • Wu, Chia-En
  • Chuang, Ming-Hung
  • Peng, Chia-Tien

Abstract

A sweep voltage generator and a display panel are provided. The sweep voltage generator includes an output node, a current generating block and a voltage regulating block. The output node is used to provide a sweep signal. The current generating block is coupled to the output node, includes a detection path for detecting an output load variation on the output node, and adjusts the sweep signal provided by the output node based on the output load variation. The voltage regulating block is coupled to the output node for regulating a voltage of the output node.

IPC Classes  ?

  • G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
  • G09G 3/20 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix

99.

BIOELECTRIC NEUROMODULATION FOR HEMATOPOIESIS REGULATION DURING CHEMOTHERAPY

      
Application Number 18205274
Status Pending
Filing Date 2023-06-02
First Publication Date 2024-01-18
Owner
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (USA)
  • NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Liu, Wentai
  • Shen, Meng-Ru
  • Chen, Li-Hsien
  • Hsu, Ya-Ting

Abstract

A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current/Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and/or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.

IPC Classes  ?

  • A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
  • A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode

100.

DEPOSITION APPARATUS

      
Application Number 18173763
Status Pending
Filing Date 2023-02-23
First Publication Date 2024-01-11
Owner NATIONAL CHENG KUNG UNIVERSITY (Taiwan, Province of China)
Inventor
  • Chang, Yu Chi
  • Chen, Zhao-Cheng

Abstract

A deposition apparatus includes a chamber, a susceptor, several injection pipes, and a plasma device. The susceptor is disposed within the chamber and is configured to carry a substrate. The injection pipes are respectively disposed in and pass through an upper portion of the chamber and are located over the susceptor. A nozzle of each of the injection pipes is tangent to an inner side surface of the chamber, so that several process gases ejected through the nozzles of the injection pipes respectively rotate along the inner side surface of the chamber. The process gases at least include a precursor gas. The plasma device is disposed in and passes through a top of the chamber, and is configured to generate plasma within the chamber to activate the precursor gas to form activators.

IPC Classes  ?

  • C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
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