Arkansas Children's Hospital Research Institute, Inc. (USA)
Inventor
Johnson, Tara
Strasser, Timothy
Burcham, Landon
Scott, Jacob
Meza, Ricardo
Abstract
An automated therapeutic device and methods thereof for heating and extending a patients curled fingers is provided. The device includes a rigid base extending from a patients hand to elbow, a plurality of fingerlets, each operable to attach to a finger of the patient, a plurality of extending elements, each extending element operable to reversibly attach to the rigid base and reversibly attach to one of the plurality of fingerlets, and a heating element operable to reversibly attach to the rigid base and distribute heat along the patient's anterior forearm.
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE (USA)
Inventor
Nienaber, Thomas
Villafranca, Adria Abella
Sexton, Kevin
Sanford, Joseph
Perez, Sarah
Abstract
Disclosed herein is an endotracheal tube cuff having a first layer, a second layer, and one or more sensors in a space between the first and second layers. The one or more sensors are operable to measure pressure between the endotracheal tube cuff and a tracheal wall of a patient. Also disclosed herein are methods of detecting a leak and preventing ischemia using the endotracheal tube cuff.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
G01L 7/02 - Measuring the steady or quasi-steady pressure of a fluid or a fluent solid material by mechanical or fluid pressure-sensitive elements in the form of elastically-deformable gauges
3.
METHODS AND SYSTEMS FOR PREDICTING THE EFFECT OF INHALED AND INFUSED ANESTHETICS
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE (USA)
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (USA)
Inventor
Sexton, Kevin
Wu, Jingxian
Jensen, Morten
Jensen, Hanna
Bonasso, Patrick
Henry, Kaylee
Sanford, Joseph
Al-Alawi, Ali
Dassinger Iii, Melvin
Abstract
Disclosed herein are systems and methods for non-invasively predicting a hemodynamic state and/or an anesthetic depth of a patient, such as a pediatric patient. The method may include receiving a peripheral venous pressure (PVP) waveform from the patient, cleaning the PVP waveform, transforming the PVP waveform into the frequency domain, and automatically predicting the hemodynamic state and/or the anesthetic depth of the patient.
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE, INC. (USA)
Inventor
Johnson, Tara
Strasser, Timothy
Burcham, Landon
Scott, Jacob
Meza, Ricardo
Abstract
An automated therapeutic device and methods thereof for heating and extending a patient's curled fingers is provided. The device includes a rigid base extending from a patient's hand to elbow, a plurality of fingerlets, each operable to attach to a finger of the patient, a plurality of extending elements, each extending element operable to reversibly attach to the rigid base and reversibly attach to one of the plurality of fingerlets, and a heating element operable to reversibly attach to the rigid base and distribute heat along the patient's anterior forearm.
A61H 1/02 - Stretching or bending apparatus for exercising
A61H 23/02 - Percussion or vibration massage, e.g. using supersonic vibrationSuction-vibration massageMassage with moving diaphragms with electric or magnetic drive
A63B 21/00 - Exercising apparatus for developing or strengthening the muscles or joints of the body by working against a counterforce, with or without measuring devices
A63B 23/16 - Exercising apparatus specially adapted for particular parts of the body for limbs, i.e. upper or lower limbs, e.g. simultaneously for upper limbs for hands or fingers
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (USA)
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE, INC. (USA)
Inventor
James, Laura P.
Hinson, Jack
Roberts, Dean
Gill, Pritmohinder S.
Abstract
The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP- prptein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
6.
ACETAMINOPHEN-PROTEIN ADDUCT ASSAY DEVICE AND METHOD
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS (USA)
ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE, INC. (USA)
Inventor
Lumpkin, Charles, K., Jr.
Abstract
Compositions that stimulate osteoblastogenesis and the activity of osteoblasts are disclosed. Methods of stimulating osteoblastogenesis and the activity of osteoblasts are disclosed. Methods of treating a mammal for a bone condition by stimulating osteoblastogenesis and the activity of osteoblasts are disclosed. According to the present invention, a composition comprising a TNF blocker is administered to the mammal in an amount effective to stimulate osteoblastogenesis.
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