Deep draw formed or shaped blister containers in various configurations are made from a two or more step process of shaping a blister recess in which a first step draws the film to provide the maximum amount of area ratio for the final blister recess and a second step shapes the blister recess. Containers can contain food or nutritional products including sterilized nutritional products for humans or for pets.
B65B 47/04 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved by application of mechanical pressure
B65B 25/00 - Packaging other articles presenting special problems
B65B 41/00 - Supplying or feeding container-forming sheets or wrapping material
B65B 47/00 - Apparatus or devices for forming pockets or receptacles in or from sheets, blanks, or webs, comprising essentially a die into which the material is pressed or a folding die through which the material is moved
2.
DEVICES AND SYSTEMS FOR AIR ASSISTED DRY POWDER ADMINISTRATION
The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The disclosed devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.
A61M 16/01 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes specially adapted for anaesthetising
A61M 16/10 - Preparation of respiratory gases or vapours
A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
B05D 7/14 - Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to metal, e.g. car bodies
B05D 5/06 - Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures to obtain multicolour or other optical effects
3.
DEVICES AND METHODS FOR PACKAGING AND DISPENSING UNIT DOSES OF PERSONAL CARE PRODUCTS
Packaging and delivery systems for personal care products and methods of providing samples or single units of use, include dispensing devices that produce a spray, mist, or stream delivery of measured amounts of personal care products packaged in internally pierced blister unit doses which protect the quality of the unused product and reduce the amount of product wasted in providing samples.
A piercing device for use in internally pierced blister delivery devices include a base, a piercer body and an internal fluid path. The internal fluid path includes one or more inlet channels into a central cavity which is connected to one or more delivery channels and exit openings. The cavity is defined by angular walls and top to create turbulence in the fluid flow and to produce a controllable spray, mist, drops, plume or stream delivery. The piercer body also provides a pointed lancet disposed in the center of the exit openings for piercing the lidstock of a formed blister.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
5.
FULLY SELF-CONTAINED UNIT DOSE DEVICES FOR ALLERGY SKIN TESTING
The present invention discloses a system for applying antigens or other diagnostic substances to the skin of a subject for allergy testing. The system is comprised of fully contained predetermined quantities of antigenic or other testing material contained in sealed unit doses that maintain sterility and provide for precise handling and administration. Each unit dose contains an internal mechanism. The mechanism provides for piercing the laminate and comprises an internal channel for fluid communication, and may have abrasive protrusions at the tip for piercing or abrading the skin surface to aid in generating a diagnostic response. The unit dose or doses may be housed in devices that provide for administration of the test material to the subject wherein the applicator section may contain protrusions for piercing or abrading the skin of a subject.
Devices for delivery of medical compositions in either liquid or powder form include a piercing device for piercing a flexible sheet material in which when contained in a flexible blister dosage form, the piercing device serves as a delivery channel for compositions contained in the blister. The device is configured to reduce or inhibit puncture flap interference with the delivered spray or mist by forming a substantial non-contact drape in the material prior to puncture.
The present disclosure is directed to processes for manufacturing shaped articles for unit-dose packaging with at least one formed recess (e.g., a blister), in particular for unit-dose packaging of pharmaceutical dosage forms, hi certain embodiments, the first step of the process is directed to drawing the film material (e.g., metal-plastic foil) with one or more plungers to form a primary contour, the contour having a depth of at least 100% and up to 150% of the depth of the formed recess. The second stage involves shaping the primary contour with one or more plunger(s) to the desired formed recess, with a depth that is less than the depth of the primary contour, while substantially maintaining the surface area of the primary contour formed in the first stage. The formed recess may be formed using warm-forming or cold-forming techniques.
B65D 85/42 - Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for ampoulesContainers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for lamp bulbsContainers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for electronic valves or tubes
B65D 83/04 - Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
Dosage forms containing pharmaceutical compositions for use in devices to produce a spray or mist delivery of the compositions include dosage blister compartments and a dispensing blister compartment, wherein crushing of the compartments delivers the compositions in a desired spray pattern. Certain dosage forms include a plurality of dosage chambers each containing a component or a portion of a pharmaceutical composition, the contents of which are mixed or combined just prior to or during administration.
Intranasal delivery devices include dosage forms containing medical compositions for use in the intranasal devices, and methods of delivering medical compositions to the nasal mucosa of users. The devices dispense a predetermined quantity of fluid into the nasal passage of a user, in which the predetermined quantity of fluid is contained in, or produced in a dosage form or blister that is crushed by a plunger with sufficient force to drive the dosage form against a piercing mechanism, piercing the dosage form and forcing the liquid contents from the dosage form and through a delivery channel into a spray to be directed into the nasal passage of a user. The plunger is connected to a trigger device by a linkage that confers a mechanical advantage to the trigger mechanism.
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