Abstract

Provided herein are computer-implemented methods of predicting a biomolecule sequence to which a target antibody binds. In some embodiments, the methods include passing at least one target antibody data set through a model that relates antibody binding to biomolecule sequence, wherein the model was created using one or more antibody-biomolecule binding data sets produced by determining binding affinity values of one or more reference antibodies to biomolecules in a biomolecule library, and wherein the target antibody data set is representative of one or more attributes of the target antibody and is sufficient for the model to produce a prediction of one or more biomolecule sequences to which the target antibody binds, and outputting from the model one or more predicted cognate epitope sequences and/or one or more predicted off-target biomolecule sequences to which the target antibody binds. Related systems, computer readable media, and additional methods are also provided.

IPC Classes  ?

• G16B 20/30 - Detection of binding sites or motifs
• G06N 3/00 - Computing arrangements based on biological models
• G06N 3/02 - Neural networks
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• G06N 20/00 - Machine learning

Abstract

Aspects of the present invention relate to a tray device including a frame having a top surface, a bottom surface, and a thickness, wherein the top surface of the frame has a first recessed region having a sidewall around at least a portion of a perimeter, and a ledge extending laterally from the bottom of the sidewall of the first recessed region, wherein the sidewall defines at least a portion of a first shape, a second recessed region having a sidewall around at least a portion of a perimeter, and a ledge extending laterally from the bottom of the sidewall of the second recessed region, wherein the sidewall defines at least a portion of a second shape, and wherein the depth of the first recessed region is deeper into the thickness of the tray than the depth of the second recessed region.

IPC Classes  ?

• B01L 9/00 - Supporting devicesHolding devices

Abstract

A method for fabricating a layered sorbent film is disclosed. The method includes forming a first sorbent layer by adhering a particulate sorbent material to a first adhesive surface of an adhesive film, the adhesive film further including a second adhesive surface coupled to a sacrificial liner. The method also includes removing the sacrificial liner from the adhesive film by exposure to a release medium, uncovering the second adhesive surface, and then forming a second sorbent layer by adhering the particulate sorbent material to the uncovered second adhesive surface. The method may also include separating a first release liner from the first adhesive surface of the adhesive film, uncovering the first adhesive surface. The sacrificial liner may be sufficiently rigid that while the sacrificial liner is coupled to the second adhesive surface, the first release liner may be removed from the adhesive film without causing mechanical damage.

IPC Classes  ?

• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/30 - Processes for preparing, regenerating or reactivating

Abstract

A walking rover system with a rover, a base station, and a tether extending between the rover and the base station. The rover has a rover body, a plurality of mobilizing legs, and a plurality of stabilizing legs. The stabilizing legs have one degree of freedom and the mobilizing legs have three degrees of freedom. The mobilizing legs and the stabilizing legs may alternate around the rover body such that each of the mobilizing legs is separated from adjacent mobilizing legs by a stabilizing leg and each of the stabilizing legs is separated from adjacent stabilizing legs by a mobilizing leg. The tether is configured to transmit electricity from the base station to the rover, transmit data gathered by the rover back to the base station, and support a weight of the rover and act as a mechanical rappel line between the base station and the rover.

IPC Classes  ?

• B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
• B25J 9/16 - Programme controls
• B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
• B25J 19/02 - Sensing devices

Abstract

Provided herein are methods of detecting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a sample. The methods include contacting the sample with a plurality of gold nanoparticles (AuNPs) and/or other plasmonic metal nanoparticles (MNPs) that are conjugated with at least two sets of antibodies, or antigen binding portions thereof, that binds to at least first and second epitopes of SARS-CoV-2 proteins, such as receptor-binding domain (RBDs) under conditions sufficient for the antibodies, or the antigen binding portions thereof, to bind to the first and second epitopes of the SARS-CoV-2 proteins in the sample to produce bound SARS-CoV-2 proteins. The methods also include detecting the SARS-CoV-2 proteins when aggregations of the bound SARS-CoV-2 proteins form with one another. Related compositions, reaction mixtures, devices, kits, and systems are also provided.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/553 - Metal or metal coated

Abstract

Provided herein are lipid nanoparticle complex with nanoparticles cloaked in monocyte plasma membrane. The nanoparticles of the lipid nanoparticle complex can be loaded with imaging agents. Also provided are methods of using the lipid nanoparticle complex for targeting and imaging of atherosclerosis in a subject in need thereof.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/00 - Preparations for testing in vivo
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

A framework that brings together application development, resource management, and accelerator design into a single compilation and runtime toolchain. In one example aspect, a method for enabling execution of multiple software applications on an embedded system includes receiving a first invocation of an Application Programing Interface (API) function by a first software application and a second invocation of the API function by a second software application, and determining available computing resources corresponding to the API function. The method includes selecting, based on one or more characteristics associated with the available computing resources, a first set of computing resources and a second set of computing resources. The method also includes scheduling the first invocation of the API function using the first set of computing resources and scheduling the second invocation of the API function using the second set of computing resources.

IPC Classes  ?

• G06F 8/41 - Compilation
• G06T 1/20 - Processor architecturesProcessor configuration, e.g. pipelining
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 9/38 - Concurrent instruction execution, e.g. pipeline or look ahead
• G06F 13/00 - Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
• G06F 15/78 - Architectures of general purpose stored program computers comprising a single central processing unit

Abstract

222222222-consuming microorganisms in the aqueous medium.

IPC Classes  ?

• B01D 53/46 - Removing components of defined structure
• B01D 53/62 - Carbon oxides
• B01J 41/04 - Processes using organic exchangers
• B01D 71/76 - Macromolecular material not specifically provided for in a single one of groups

Abstract

A system and method for training the machine learning models of the multiple-input multiple-output (MIMO) communication systems. The system and method cluster the training data based on the device position. Then, separate models are trained based on the data for each position. The system and method can be applied to the design of machine learning-based beamforming, precoding, channel compression, channel estimation, and codebook design among other applications. The system uses the implicit or explicit user position information to select the right zone-specific model and its parameters.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04W 24/02 - Arrangements for optimising operational condition

Abstract

The present invention provides nanoparticles or conjugates comprising at least one ligand that selectively targets major facilitator superfamily domain-containing protein-2a (MFSD2A). In various embodiments, the nanoparticles or conjugates of the invention target at least one cell comprising MFSD2A (e.g., endothelial cells of blood brain barrier). In some embodiments, the nanoparticles or conjugates of the invention cross the blood brain barrier and/or blood retinal barrier. In other aspects, the present invention relates to methods for in vivo delivery of diagnostic and/or therapeutic agents to a brain. In other aspects, the present invention relates to methods of preventing or treating a neurological or cognitive disease or disorder using the nanoparticles or conjugates of the invention.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides devices, systems, and methods for selectively functionalizing electrodes in bioelectronic devices and for bridging gaps between electrodes.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

2222.

IPC Classes  ?

• B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/34 - Chemical or biological purification of waste gases
• B01D 53/81 - Solid phase processes

Abstract

The present invention provides antimicrobial nanoparticles or compositions thereof comprising at least one phytochemical or bioactive compound, at least one lipid, at least one surfactant, and at least one vitamin E. In some embodiments, the antimicrobial nanoparticles or compositions thereof further comprise at least one coating agent. In some embodiments, the antimicrobial nanoparticles or compositions thereof are an edible coating. In various aspects, the present invention relates to methods of reducing or inhibiting the activity or level of or preventing the growth of at least one microorganism on a surface of an element. In some aspects, the present invention relates to methods of increasing a shelf-life of food and/or maintaining and improving food nutrients and/or nutrition values. In other aspects, the present invention relates to methods of delivering at least one nutritional or bioactive agent for preventing and treating various disorders and diseases.

IPC Classes  ?

• A61K 31/355 - Tocopherols, e.g. vitamin E
• A23B 7/16 - Coating with a protective layerCompositions or apparatus therefor
• A23L 33/15 - Vitamins
• A61K 9/51 - Nanocapsules
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Synthesizing an ionene polymer includes combining a soft segment, a hard segment, and a solvent to yield a mixture, and heating the mixture to yield the ionene polymer. The soft segment includes bromine end-capped poly(tetramethylene oxide (Br-PTMOn-Br), and the hard segment comprises a linear aliphatic compound or 1,4-diazabicyclo[2.2.2]octane (DABCO).

IPC Classes  ?

• C08G 73/02 - Polyamines

Abstract

In accordance with some embodiments of the disclosed subject matter, systems, methods, and media for automatically transforming a digital image into a simulated pathology image are provided. In some embodiments, the method comprises: receiving a content image from an endomicroscopy device; receiving, from a hidden layer of a convolutional neural network (CNN) trained to recognize a multitude of classes of common objects, features indicative of content of the content image; receiving, providing a style reference image to the CNN; receiving, from another hidden layer of the CNN, features indicative of a style of the style reference image; receiving, from the hidden layers of the CNN, features indicative of content and style of a target image; generating a loss value based on the features of the content image, the style reference image, and the target image; minimizing the loss value; and displaying the target image with the minimized loss.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

66666266666 -with HO- in the layer to yield the membrane, wherein the membrane comprises a PSf-PDADMA(OH) block copolymer.

IPC Classes  ?

• B01D 71/66 - Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/68 - PolysulfonesPolyethersulfones
• C08G 75/20 - Polysulfones
• B01D 71/06 - Organic material

Abstract

A bioproduct manufacturing system is disclosed. The system comprises a hollow-fiber primary membrane gas absorber comprising a shell side and a lumen, wherein the primary membrane gas absorber is configured to receive a carbonate salt-based solvent on the shell side and a gas mixture comprising oxygen, nitrogen, and carbon dioxide in the lumen, at least one runway algal cassette reactor-photobioreactor, and a growth medium circulating between the primary membrane gas absorber and the at least one runway algal cassette reactor-photobioreactor. The at least one runway algal cassette reactor-photobioreactor comprises at least one growth chamber coupled to and in fluid communication with a headspace channel so as to define an interior volume, a first condenser coupled to and in fluid communication with the headspace channel, and a harvest line in fluid communication with the at least one growth chamber and coupled to a filter.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/04 - Apparatus for enzymology or microbiology with gas introduction means
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

A system and method for gesture sensor using radio-frequency signals. In some embodiments, a system includes a band configured to fit on the wrist of a user. The band may include a first electromagnetic coupling circuit having a first feed port, the first electromagnetic coupling circuit being configured to: receive a first drive signal at the first feed port, couple the first drive signal to tissues of the wrist, receive a first reflected signal from the tissues of the wrist, and couple the first reflected signal to the first feed port.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G01S 7/02 - Details of systems according to groups , , of systems according to group
• G01S 13/06 - Systems determining position data of a target
• H01P 5/12 - Coupling devices having more than two ports
• H01Q 1/22 - SupportsMounting means by structural association with other equipment or articles
• H01Q 13/20 - Non-resonant leaky-waveguide or transmission-line antennas Equivalent structures causing radiation along the transmission path of a guided wave

Abstract

This invention is directed to systems, compositions, and methods of producing food.

IPC Classes  ?

• C05G 5/40 - Fertilisers incorporated into a matrix
• A01G 18/20 - Culture media, e.g. compost
• A23L 31/00 - Edible extracts or preparations of fungiPreparation or treatment thereof
• C05C 9/00 - Fertilisers containing urea or urea compounds
• C05D 9/02 - Other inorganic fertilisers containing trace elements
• C05G 3/50 - SurfactantsEmulsifiers

Abstract

A system comprising a memory to store instructions and a processor to execute the instructions stored in the memory to receive a plurality of Computed Tomography Pulmonary Angiography (CTPA) exams as input image data, each exam in the plurality of exams comprising a varying plurality of individual images. The system annotates each of the slices with one of a pulmonary embolism (PE) present label or PE absent label, annotates each of the exams with one of a plurality of labels each indicating a different PE state and location, performs a slice-level PE classification to determine the presence or absence of PE for each of the slices, and performs and outputs, via an Embedding-based Vision Transformer (E-ViT), an exam-level diagnosis using the slice-level classifications.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 20/70 - Labelling scene content, e.g. deriving syntactic or semantic representations
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

Aspects of the present invention relate to a method for using electrical impedance tomography (EIT) to reconstruct electrical property distributions in a patient subjected to an electrode array, including the steps of measuring electrode outputs from the electrode array configured to an anatomical position of the patient, and mapping the electrical property distributions of the measured electrode outputs with a deep neural network (DNN).

IPC Classes  ?

• A61B 5/0536 - Impedance imaging, e.g. by tomography
• G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
• A61B 5/0295 - Measuring blood flow using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• G06T 11/00 - 2D [Two Dimensional] image generation

Abstract

Example systems and methods include measurement of physiological signals emitted from the human body to distinguish humans from automated bots on the Internet as well as integrate biometric sensors to capture physiological and acoustic signals indicative of natural human speech.

IPC Classes  ?

• G10L 17/20 - Pattern transformations or operations aimed at increasing system robustness, e.g. against channel noise or different working conditions

Abstract

The disclosure is drawn towards sustainable functionalization and methods of use thereof.

IPC Classes  ?

• C12P 7/20 - Glycerol
• C12N 9/18 - Carboxylic ester hydrolases
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• C12P 13/02 - Amides, e.g. chloramphenicol
• C12P 19/02 - Monosaccharides

Abstract

A system can identify a quantitative biomarker for migraine in real-time from electrophysiological measurements and can be made using current wearable devices. The system uses the quantitative biomarker to track the onset and offset of migraine and also the degree of migraine pain which can be incorporated to guide and control occipital nerve stimulation parameters.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61B 5/293 - Invasive

Abstract

Example systems and methods include measurement of physiological signals emitted from the human body to distinguish humans from automated bots on the Internet as well as integrate biometric sensors to capture physiological and acoustic signals indicative of natural human speech.

IPC Classes  ?

• G06V 40/40 - Spoof detection, e.g. liveness detection
• G06V 40/70 - Multimodal biometrics, e.g. combining information from different biometric modalities
• G10L 15/25 - Speech recognition using non-acoustical features using position of the lips, movement of the lips or face analysis
• G10L 17/26 - Recognition of special voice characteristics, e.g. for use in lie detectorsRecognition of animal voices
• G06F 18/21 - Design or setup of recognition systems or techniquesExtraction of features in feature spaceBlind source separation
• G06N 3/02 - Neural networks
• G06N 20/00 - Machine learning
• G10L 17/06 - Decision making techniquesPattern matching strategies
• G10L 25/03 - Speech or voice analysis techniques not restricted to a single one of groups characterised by the type of extracted parameters
• G10L 25/57 - Speech or voice analysis techniques not restricted to a single one of groups specially adapted for particular use for comparison or discrimination for processing of video signals

Abstract

A high electron mobility transistor current-aperture vertical electron transistor includes a drain electrode, a source electrode, gate electrode, an n− doped drift layer comprising β-Ga2O3, a first n++ Ga2O3 layer between the drain electrode and the n− doped drift layer, a current blocking layer, a second n++ Ga2O3 layer between the current blocking layer and the source electrode, and a delta-doped β-(AlxGa1-x)2O3/Ga2O3 heterostructure between the portion of the n doped drift layer and the gate electrode. A portion of the n− doped drift layer defines an aperture in the current blocking layer.

IPC Classes  ?

• H01L 29/778 - Field-effect transistors with two-dimensional charge carrier gas channel, e.g. HEMT
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or

Abstract

An environmental monitoring system with a plurality of sensor units and an imaging system. The sensor units are configured to be distributed over a monitored area and to collect spatiotemporal data. Each of the sensor units may have a temperature sensor, an air pressure sensor, a humidity sensor, a clock, and/or a Wi-Fi transceiver. The sensor units are configured to communicatively couple together to form a sensor network. The imaging system may be configured both for handheld use and for mounted use. The imaging system may have a camera and a spectrometer. The imaging system is configured to generate a real-time semantic map of the area and position the sensor units on the semantic map. The environmental monitoring system is configured to use the semantic map and the spatiotemporal data to predict a need of the monitored area and variation of the need across the monitored area.

IPC Classes  ?

• G01J 3/28 - Investigating the spectrum
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G06V 20/10 - Terrestrial scenes

Abstract

A Ga2O3 heterojunction bipolar device includes a first electrode, a second electrode, a β-Ga2O3 substrate between the first electrode and the second electrode, and a NiOx layer in contact with (201), (001), or (010) plane of the β-Ga2O3 substrate. A surface of the β-Ga2O3 substrate defines a (201), (001), or (010) plane, and the interface between the NiOx layer and the β-Ga2O3 substrate is a p-n heterojunction. Fabricating the Ga2O3 heterojunction bipolar device includes depositing a first electrode on a surface of a Ga2O3 substrate defining a (201), (001), or (010) plane of the β-Ga2O3 substrate, depositing a NiOx layer on an opposite surface of the substrate, and depositing a second electrode on the NiOx layer to yield the device.

IPC Classes  ?

• H01L 29/737 - Hetero-junction transistors
• H01L 29/04 - Semiconductor bodies characterised by their crystalline structure, e.g. polycrystalline, cubic or particular orientation of crystalline planes
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or
• H01L 29/66 - Types of semiconductor device

Abstract

Described herein are compositions comprising RNA origami (RNAOG) which include 5-fluorouracil (5FU) or analogues thereof are described which can be used to both directly treat a cancer by inhibiting a biochemical pathway overexpressed in a cancer cell and indirectly treat a cancer by inducing an anti-cancer immune response. Also described herein are methods of using said compositions for treating cancer, inducing an anti-cancer immune response, and/or killing a cancer cell.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/443 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
• A61K 31/513 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents

Abstract

A system implements a modeling (ClassGP) and an optimization (ClassBO) framework that models heterogeneous functions with knowledge of individual partitions within classes, i.e., heterogeneous functions including non-stationary functions which can be divided into locally stationary functions over partitions of input space with an active stationary function in each partition. The framework constructs a class likelihood for the class by combining log marginal likelihoods associated with each partition of the plurality of partitions within the class. The framework aims to improve analysis of systems that are characterized by a discrete and finite number of “classes” of behaviors.

IPC Classes  ?

• G06F 17/13 - Differential equations

Abstract

The present disclosure provides an anti-galectin-1 monoclonal antibody and methods of its use to detect intracellular or cell surface galectin-1. The disclosure also provides methods for using the anti-galectin-1 antibody to detect β-galactoside on a cell surface.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A high-altitude balloon payload with a frame, a GPS and compass module, a flight controller, a sensor probe, an orientation control system and an antenna. The frame is configured to be suspended from a high-altitude balloon. The GPS and compass module is mounted on the frame and is configured to collect location data and orientation data of the frame. The flight controller is mounted on the frame and is configured to control the orientation of the frame based on the location data and the orientation data. The orientation control system is mounted on the frame, operatively coupled to the flight controller, and configured to provide control of the orientation of the frame. The sensor probe is positioned on the frame and configured to take atmospheric measurements. The antenna is configured to establish a radio telemetry link with a ground station and wirelessly communicate the atmospheric measurements to the ground station.

IPC Classes  ?

• B64U 10/30 - Lighter-than-air aircraft, e.g. aerostatic aircraft
• B64U 20/87 - Mounting of imaging devices, e.g. mounting of gimbals
• B64U 50/31 - Supply or distribution of electrical power generated by photovoltaics
• B64U 101/35 - UAVs specially adapted for particular uses or applications for science, e.g. meteorology

Abstract

A method of adaptively scanning a selected area that includes selecting an imaging mode, performing a scan of the selected area using the imaging mode, detecting an item of interest, automatically selecting a new imaging mode in response to detecting the item of interest, and performing a scan of the item of interest using the new imaging mode. The imaging mode may determine at least one of a scanning pattern, a scanning speed, and a scanning rate. Spectral data and image data may be gathered and used to detect the item of interest. The method may also include providing a scanning spectrometer system that has a gimbal system configured to provide at least two degrees of freedom to the scanning spectrometer system. The gimbal system may have a spectrometer and a camera each mounted on the gimbal system and configured to gather the spectral data and the image data, respectively.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• B25J 19/02 - Sensing devices
• G01J 3/06 - Scanning arrangements
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/28 - Investigating the spectrum
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

Provided herein are methods of quantifying protein folding and stability. Some embodiments provide methods of detecting a misfolded target protein that include determining a growth rate or relative fitness of a first cell population that comprises a first fusion polypeptide comprising a first variant of a target protein disposed between segments of a toxic indicator protein, which segments together induce the first cell population to grow at a lower rate when the target protein is relatively less misfolded than when the target protein is relatively more misfolded, and determining that the growth rate or fitness of the first cell population varies from a growth rate or fitness of a second cell population that comprises a second fusion polypeptide comprising a second variant of the target protein disposed between the segments of the toxic Indicator protein. Related nucleic acids, kits, and systems are also provided.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/36 - Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Described herein are means for systematically generating transparent models for computer vision and image recognition utilizing deep learning non-transparent black box models. According to a particular embodiment, there is a specially configured system for generating an explainable AI model by performing operations, including: training a Convolutional Neural Network (CNN) to classify objects; training a Convolutional Neural Network (CNN) to classify objects from training data having a set of training images; training a multi-layer perceptron (MLP) to recognize both the objects and parts of the objects; generating the explainable AI model based on the training of the MLP; receiving an image having an object embedded therein, wherein the image forms no portion of the training data for the explainable AI model; executing the CNN and the explainable AI model within an image recognition system, and generating a prediction of the object in the image via the explainable AI model; recognizing parts of the object; providing the parts recognized within the object as evidence for the prediction of the object; and generating a description of why the image recognition system predicted the object in the image based on the evidence comprising the recognized parts.

IPC Classes  ?

• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G06V 10/778 - Active pattern-learning, e.g. online learning of image or video features

Abstract

An electro-regeneration system for a sorbent includes a vessel having an inlet and an outlet, a pump fluidly coupled to the inlet, an anode positioned at least partially in the vessel, and a cathode positioned at least partially in the vessel. The cathode includes an electrically conductive sorbent. A power source is electrically coupled to the anode and the cathode. Regenerating a PFAS-laden sorbent includes applying current from the power source to the cathode, thereby electrostatically repelling the PFAS from the electrically conductive sorbent, and regenerating the sorbent to yield a regenerated sorbent.

IPC Classes  ?

• C02F 1/28 - Treatment of water, waste water, or sewage by sorption
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis
• H01M 4/96 - Carbon-based electrodes
• B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes

Abstract

The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

IPC Classes  ?

• A61K 9/06 - OintmentsBases therefor
• A61K 38/20 - Interleukins
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons

Abstract

The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

A computer implemented system ("ExAct") generates counterfactual explanations for chronic disease prevention and management. Leveraging insights from adversarial learning, ExAct characterizes the decision boundary for high-dimensional data and performs a grid search to generate actionable interventions. ExAct is unique in integrating prior knowledge about user preferences of feasible explanations into the process of counterfactual generation. ExAct is evaluated extensively using four real-world datasets and external simulators.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
• G06N 3/08 - Learning methods
• G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data

Abstract

The present disclosure provides devices, systems, and methods related to bioelectronic devices. In particular, the present disclosure provides bioelectronic devices, and methods of making bioelectronic devices, comprising conductive anchors and conductive anchor binding moieties to minimize contact resistance of a protein-of-interest coupled to electrodes in the bioelectronic devices. The bioelectronic devices and methods of the present disclosure are useful for a variety of applications, including the direct measurement of protein activity.

IPC Classes  ?

• H10K 85/00 - Organic materials used in the body or electrodes of devices covered by this subclass
• G01N 27/327 - Biochemical electrodes
• G01N 33/487 - Physical analysis of biological material of liquid biological material
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Abstract

A surgical clip with one or more premagnetized elements is configured to be delivered with an endoscope or similar device, and a system and method for manipulating tissue during a surgical procedure using such a surgical clip, are provided. At least one magnetic field source arranged external to an animal body is moved using at least one robotic actuator, and a magnetic field generated thereby is used to alter position of one or more surgical clips affixed to tissue. A surgical clip includes a tubular body structure, a grasping element, and internal elements within the body structure, wherein at least portions of one or more of the body structure and the internal elements comprise a premagnetized material configured to cooperate with a magnetic end effector external to the animal body to permit manipulation of tissue.

IPC Classes  ?

• A61B 17/10 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for applying or removing wound clampsWound clamp magazines
• A61B 17/08 - Wound clamps
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for

Abstract

A surgical clip with a tethered magnetic element configured to be delivered with an endoscope or similar device, and a system and method for manipulating tissue during a surgical procedure using such a surgical clip, are provided. At least one magnetic field source arranged external to an animal body is moved using at least one robotic actuator, and a magnetic field generated thereby is used to alter position of one or more surgical clips affixed to tissue. A surgical clip includes a tubular body structure, a grasping element, and internal elements within the body structure. While the surgical clip grasps tissue, the tethered magnetic element is configured to cooperate with a magnetic end effector external to the animal body for manipulation of tissue.

IPC Classes  ?

• A61B 17/10 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for applying or removing wound clampsWound clamp magazines
• A61B 17/08 - Wound clamps
• A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
• A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for

Abstract

A system infers continuous potential energy landscapes, including barrier heights and friction coefficients, from smFRET data without the need to discretely approximate a state-space. The system operates within a Bayesian nonparametric paradigm by placing priors on the family of all possible potential curves, and leverages a Structured-Kernel-Interpolation Gaussian Process prior to help curtail computational cost. The system enables decoding information about continuous energy potential landscapes along a continuous coordinate for biological interactions (e.g., protein folding and binding) using a single dataset, including rarely visited barriers between putative potential minima. As such, the system allows resolution enhancement for probing biophysical systems to obtain deeper insight into protein folding, protein binding, and the physics of molecular motors.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks

Abstract

A method of manufacturing a semiconductor device comprising the steps of: providing an inkjet printer having a conductive nozzle in a zero gravity or microgravity environment; positioning a substrate at an outlet of the conductive nozzle; printing a metal material with the inkjet printer to form at least one metal layer on the substrate; and printing an insulating material with the inkjet printer to form an insulating layer on at least a portion of the first metal layer; wherein the conductive nozzle is configured to form a Taylor Cone with the metal material or the insulating material. Related devices are also disclosed.

IPC Classes  ?

• B41J 2/06 - Ink jet characterised by the jet generation process generating single droplets or particles on demand by electric or magnetic field
• B41J 2/135 - Nozzles
• B41J 2/14 - Structure thereof
• G11C 13/00 - Digital stores characterised by the use of storage elements not covered by groups , , or
• H10B 63/00 - Resistance change memory devices, e.g. resistive RAM [ReRAM] devices
• H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching
• B41J 2/01 - Ink jet

Abstract

A system and method for airborne dispensing. In some embodiments, the system includes a hopper and a metering wheel. The metering wheel may be configured to extract pellets, one at a time, from the hopper.

IPC Classes  ?

• A01C 7/12 - Seeders with feeding-wheels
• A01C 19/02 - Arrangements for driving working parts of fertilisers or seeders by a motor
• A01C 17/00 - Fertilisers or seeders with centrifugal wheels
• A01C 7/20 - Parts of seeders for conducting and depositing seed
• B64D 1/16 - Dropping or releasing powdered, liquid or gaseous matter, e.g. for fire-fighting

Abstract

A non-contact maternal / fetal physiological activity monitoring system includes a radar sensor (e.g., mm-wave radar emitter and receiver) and a signal processor configured to select at least one pair of range and angle coordinates of a received radar signal, and for each range and angle coordinate pair: generate a selected heart activity signal, perform high-pass or bandpass filtering, and process a filtered heart activity signal to generate an estimated heart rate signal and audio signal (including a cardiac acoustic signal). Heart rate and audio signals may be generated for maternal, fetal, or both maternal and fetal subjects.

IPC Classes  ?

• A61B 5/024 - Measuring pulse rate or heart rate
• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves
• G01S 13/88 - Radar or analogous systems, specially adapted for specific applications
• G01S 13/58 - Velocity or trajectory determination systemsSense-of-movement determination systems

Abstract

Quantum circuits for QFT and Inverse QFT (IQFT) are disclosed that can be applied for use in signal and speech, analysis synthesis and compression. A unique method perceptual selection of QFT components is also outlined.

IPC Classes  ?

• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms

Abstract

A suction cup device is operable for precisely-controlled attachment and detachment with an object surface, and can include attachment actuators that activate to form a seal between the suction cup device and the object surface by decreasing a cavity pressure of the suction cup device. Following attachment, the attachment actuators can deactivate to hold the seal in a “passive” mode. For detachment from the object surface, the suction cup device can include detachment actuators that increase the cavity pressure to break the seal and release the object surface from the suction cup device.

IPC Classes  ?

• B25J 15/06 - Gripping heads with vacuum or magnetic holding means

Abstract

A model implemented by a processor and trained for patch embedding of anatomical consistency captures the anatomical structure consistency between patients of different genders and weights and between different views of the same patient, which enhances the interpretability for medical image analysis. The model is trained via a self-supervised learning (SSL) framework that captures both global and local patterns embedded within medical images.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.

IPC Classes  ?

• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage

Abstract

A system and method for atmospheric water extraction is disclosed. The system includes at least one extraction structure, each having a desiccant material and movable between adsorption and desorption configurations. The system also includes a condensing chamber in fluidic communication with the extraction structure, the condensing chamber configured to receive and condense water vapor into liquid water on a cooling surface. The system also includes a heating subsystem that is thermal liquid-based, with the thermal liquid in thermal contact with a heat source. The adsorption configuration includes the extraction structure being exposed to an atmosphere such that the desiccant is in fluidic contact with an airflow. The desorption configuration includes the desiccant being in fluidic communication with the cooling surface and in thermal communication with the thermal liquid such that the desiccant is heated to at least a release temperature, causing the desiccant to release adsorbed water vapor.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/26 - Drying gases or vapours

Abstract

Embodiments of the present disclosure pertain generally to head and neck squamous cell carcinomas (HNSCCs) related to human papillomavirus subtype 16 (HPV16) infections. More particularly, the present disclosure provides novel immunogenic epitopes from HPV16 E2, E6 and E7 antigens restricted by common human leukocyte antigen (HLA) alleles for the diagnosis and treatment of HNSCC. The HPV16 epitopes identified in the present disclosure can be used in combination with blockade of HPV16+ HNSCC-specific checkpoints for targeted immunotherapy.

IPC Classes  ?

• A61K 39/12 - Viral antigens
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/20 - Antivirals for DNA viruses
• A61P 35/00 - Antineoplastic agents

Abstract

This disclosure is related to materials with highly stable and reversible water sorption and retention properties, as well as formulations and methods for their manufacture and uses. Composite materials of the present disclosure can avoid weeping or leakage of liquid water at wide ranges in ambient relative humidities so as to be suitable for a variety of applications including thermal management, thermal energy storage, atmospheric water generation and dehumidification systems. Composites disclosed herein can comprise an ionomeric material and in some embodiments, a hygroscopic or deliquescent salt. Furthermore, composites disclosed herein can also include a water vapor permeable or support polymer material providing support for reversible expansion or volume changes during water vapor sorption/desorption cycling via porous and/or elastic character, thereby avoiding mechanical restriction that could cause weeping or leakage of liquid water.

IPC Classes  ?

• B01J 20/26 - Synthetic macromolecular compounds
• B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
• B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
• B01J 20/34 - Regenerating or reactivating
• C09K 5/04 - Materials undergoing a change of physical state when used the change of state being from liquid to vapour or vice-versa
• H02S 40/42 - Cooling means

Abstract

A system and method for estimating an angle of arrival. In some embodiments, the system includes an array antenna and a processing circuit. The array antenna may be curved, and may include a first radiator having a first resonant frequency and a second radiator having a second resonant frequency different from the first resonant frequency. The processing circuit may be configured to receive a signal from the array antenna and to calculate, from the signal, an estimated angle of arrival of electromagnetic radiation corresponding to the signal.

IPC Classes  ?

• G01R 29/10 - Radiation diagrams of antennas
• G01R 29/08 - Measuring electromagnetic field characteristics
• H01Q 21/20 - Arrays of individually energised antenna units similarly polarised and spaced apart the units being spaced along, or adjacent to, a curvilinear path

Abstract

Described herein is a method of purifying contaminated fluid influent, the method comprising: providing a reactor comprising a reactor inlet, a reactor outlet, and a purification composition; circulating contaminated fluid influent through the reactor to create a slag-treated fluid; providing a biochemical reactor comprising a biochemical reactor inlet, a biochemical reactor outlet, and a purification media; and circulating the slag-treated fluid through the biochemical reactor to generate a purified fluid. Also described herein is a contaminated fluid influent purification system, comprising: a reactor having a reactor inlet, a reactor outlet, and a purification composition; a biochemical reactor having a biochemical reactor inlet, a biochemical outlet, and a purification media; a settling tank; and a mixing tank; wherein the mixing tank is fluidly connected to a contaminated fluid influent source, the reactor and the settling tank; and wherein the settling tank is fluidly connected to the mixing tank and the biochemical reactor.

IPC Classes  ?

• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C02F 3/28 - Anaerobic digestion processes
• C02F 101/10 - Inorganic compounds
• C02F 101/20 - Heavy metals or heavy metal compounds
• C02F 103/10 - Nature of the water, waste water, sewage or sludge to be treated from quarries or from mining activities

Abstract

This disclosure is related to materials with highly stable and reversible water sorption and retention properties, as well as formulations and methods for their manufacture and uses. Composite materials of the present disclosure can avoid weeping or leakage of liquid water at wide ranges in ambient relative humidities so as to be suitable for a variety of applications including thermal management, thermal energy storage, atmospheric water generation and dehumidification systems. Composites disclosed herein can comprise an ionomeric material and in some embodiments, a hygroscopic or deliquescent salt. Furthermore, composites disclosed herein can also include a water vapor permeable or support polymer material providing support for reversible expansion or volume changes during water vapor sorption/desorption cycling via porous and/or elastic character, thereby avoiding mechanical restriction that could cause weeping or leakage of liquid water.

IPC Classes  ?

• C08K 3/16 - Halogen-containing compounds
• C08K 3/34 - Silicon-containing compounds
• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
• C08L 39/04 - Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
• C08L 5/08 - ChitinChondroitin sulfateHyaluronic acidDerivatives thereof
• C08L 75/00 - Compositions of polyureas or polyurethanesCompositions of derivatives of such polymers
• C08L 75/04 - Polyurethanes
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08L 61/04 - Condensation polymers of aldehydes or ketones with phenols only
• H02S 10/30 - Thermophotovoltaic systems

Abstract

Described herein are peptide-based coating molecules for stabilizing DNA nanostructures and imparting biological activity. In one embodiment, a dense coating of peptides along the outside of the DNA nanostructure facilitates endolysosomal escape and improves cell delivery. Also described herein are nanoparticle compositions comprising a DNA nanostructure functionalized with an endolysosomal escape peptide coating or one or more antibodies.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/51 - Nanocapsules
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids

Abstract

This disclosure provides compositions and methods for treating and/or preventing monkeypox infection and/or symptoms post-infection, the method including administering a composition including at least one attenuated vaccinia virus, the at least one attenuated vaccinia virus including a modification to the coding sequence of E3L.

IPC Classes  ?

• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• A61K 39/285 - Vaccinia virus or variola virus
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C12N 15/39 - Poxviridae, e.g. vaccinia virus, variola virus

Abstract

A composite catalyst includes a nickel foam and cobalt, copper, or both electrodeposited on the nickel foam. Making the composite catalyst includes contacting the nickel foam with an aqueous solution comprising copper, cobalt, or both, and electrodepositing nanodomains of copper, cobalt, or both, respectively, on the nickel foam. Electrochemically converting nitrate to ammonia includes contacting an electrode and a cathode comprising the composite catalyst in an electrochemical cell with an aqueous solution including nitrate, adsorbing the nitrate onto the copper, the cobalt, or both, reducing the nitrate to yield nitrite, and reducing the nitrite to yield ammonia.

IPC Classes  ?

• C25B 1/27 - Ammonia
• B01J 23/72 - Copper
• B01J 23/75 - Cobalt
• B01J 23/755 - Nickel
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide

Abstract

An apparatus includes a body and a plurality of members extending from the apparatus configured to form carvings with different geometries along 2D layered semiconductor material. The apparatus includes conductive pins positioned along the plurality of members that accommodate individual sensing of current-voltage characteristics per carving. The carvings can include small stripes and the apparatus can probe the electrical resistance of the small stripes of 2D layered semiconductors where the geometry defines strong current confinement, thus enabling the rapid extraction of sheet resistance for rapid comparison between material quality.

IPC Classes  ?

• G01R 31/26 - Testing of individual semiconductor devices
• H01L 21/66 - Testing or measuring during manufacture or treatment

Abstract

Aryl diimine first row metal compounds are described, as well as their synthesis and use as catalysts for the hydrofunctionalization of unsaturated organic compounds and main group element-main group element bond formation by dehydrogenative coupling.

IPC Classes  ?

• C07F 13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic Table
• C07F 15/02 - Iron compounds
• C07F 15/04 - Nickel compounds
• C07F 15/06 - Cobalt compounds

Abstract

A system and method for the automatic stimulation of a vagus nerve for post-stroke rehabilitation is disclosed. The system includes an application subsystem having an electrode positioned to stimulate the vagus nerve and coupled to a user outside of a surgical setting. The system also includes a waveform generator communicatively coupled to the electrode, and a triggering subsystem including a receiver configured to detect the presence of a tag. The triggering subsystem is communicatively coupled to waveform generator and is configured to automatically trigger the stimulation of the vagus nerve upon detecting the presence of the tag. The tag is located proximate a rehabilitation context such that the tag is detected when the user is using the rehabilitation context, resulting in the vagus nerve of the user being automatically stimulated by the electrode in response to the user's post-stroke rehabilitation training.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes
• A61N 5/06 - Radiation therapy using light

Abstract

Provided are antibodies specific for the long isoform of QSOX1 and methods of using these antibodies to detect and measure the levels of the presence of the long and short isoforms of QSOX1 in a sample.

IPC Classes  ?

• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes
• G01N 33/573 - ImmunoassayBiospecific binding assayMaterials therefor for enzymes or isoenzymes
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents

Abstract

A device for time-resolved electron microscopy includes a nozzle and a piezoelectric droplet generator. The nozzle includes a chamber defining an inlet and an outlet, a first channel in fluid communication with the inlet of the chamber, and a second channel in fluid communication with the chamber. The piezoelectric droplet generator is coupled to the first channel and to a sample source. The piezo-electric droplet generator is configured to generate and provide droplets of the sample to the chamber. The second channel is configured to provide a substrate solution to the chamber, and the droplets of the sample and the substrate solution mix in the chamber and form a fluid stream when exiting the outlet for capture on an EM slide for study.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A functional ultrathin battery separator and method for fabricating the same is disclosed. The battery separator includes a polymer substrate that is flexible, and a functional barrier layer deposed on the polymer substrate. The functional barrier layer is polycrystalline and includes a metal-organic framework and a plurality of micropores. The functional barrier layer is able to flex with the polymer substrate. The functional barrier layer is compact, such that diffusion pathways through the functional barrier layer are limited to a cutoff size, and such that the diffusion pathways that are largest are located within grains of the polycrystalline functional barrier layer rather than between grains. The battery separator may be less than 10 μm thick, and the polymer substrate may be less than 9 μm thick. The metal-organic framework may be ZIF-8, and the functional barrier layer may be less than 2 μm thick.

IPC Classes  ?

• H01M 50/403 - Manufacturing processes of separators, membranes or diaphragms
• H01M 50/429 - Natural polymers
• H01M 50/449 - Separators, membranes or diaphragms characterised by the material having a layered structure
• H01M 50/46 - Separators, membranes or diaphragms characterised by their combination with electrodes

Abstract

The disclosure relates to recombinant modified NYVAC vectors encoding one or more virus immunogens (or antigens), preferably derived from a coronavirus or an influenza virus, for use in immunological compositions, as well as methods for making and using the same.

IPC Classes  ?

• C12N 15/863 - Poxviral vectors, e.g. vaccinia virus
• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61P 31/14 - Antivirals for RNA viruses
• C07K 14/165 - Coronaviridae, e.g. avian infectious bronchitis virus

Abstract

A system for implementation within a visual sensing pipeline facilitates dynamic voltage scaling for image sensors, enabling image sensors to capture frames at varying fidelities for improved energy efficiency. The system includes hardware and software interfaces to enable dynamic voltage scaling, and are demonstrated with integration into an RPi-based streaming platform. The system is evaluated with representative IoT/AR workloads over various voltage scheduling policies.

IPC Classes  ?

• H04N 25/709 - Circuitry for control of the power supply
• H04N 23/80 - Camera processing pipelinesComponents thereof
• H04N 25/60 - Noise processing, e.g. detecting, correcting, reducing or removing noise

Abstract

A computer-implemented model is trained or otherwise configured for real-time production control. The model incorporates a plurality of classes of residence time control and optimizes produce performance by managing an associated machine's behavior according to real-time system states. The model can formulate a Markov decision process and feature-extraction method and feature-based approximation architecture to reduce state space of the model. Simulation is employed in training to estimate parameters of feature-based approximate architecture to obtain a lookahead function of the Markov decision process.

IPC Classes  ?

• G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators

Abstract

A device for passive collection of atmospheric carbon dioxide is disclosed. The device includes a release chamber having an opening and a sorbent regeneration system. The device also includes a capture structure coupled to the release chamber, having at least one collapsible support and a plurality of tiles spaced along the collapsible support. Each tile has a sorbent material. The capture structure is movable between a collection configuration and a release configuration. The collection configuration includes the capture structure extending upward from the release chamber to expose the capture structure to an airflow and allow the sorbent material to capture atmospheric carbon dioxide. The release configuration includes the collapsible support being collapsed and the plurality of tiles being sufficiently enclosed inside the release chamber that the sorbent regeneration system may operate on the plurality of tiles to release captured carbon dioxide from the sorbent material and form an enriched gas.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents

Abstract

Described are platforms, systems, media, and methods for evaluating, monitoring, and/or treating a subject for brain injury based on machine learning analysis of one or more of brain imaging features, clinical features, demographic features, or speech features.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06N 20/00 - Machine learning

Abstract

Provided herein are systems for repelling insects that include at least one row of multiple insulated conductor wires (ICWs) disposed substantially parallel to one another. The systems also include an electrical power supply operably connected to the at least one row of multiple ICWs. The electrical power supply is configured to provide electrical power to the at least one row of multiple ICWs such that charged particles move between the neighboring pairs of ICWs in the at least one row of multiple ICWs when the electrical power is provided to the at least one row of multiple ICWs by the electrical power supply. Related methods and other aspects are also provided.

IPC Classes  ?

• A01M 1/22 - Stationary means for catching or killing insects by electric means
• A01M 1/24 - Arrangements connected with buildings, doors, windows, or the like
• A01M 29/24 - Scaring or repelling devices, e.g. bird-scaring apparatus using electric or magnetic effects, e.g. electric shocks, magnetic fields or microwaves
• H01B 3/30 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances plasticsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances resinsInsulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of organic substances waxes
• H05C 1/06 - Circuits or apparatus for generating electric shock effects providing pulse voltages operating only when touched

Abstract

222 and form an enriched gas.

IPC Classes  ?

• B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
• B01D 53/06 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with moving adsorbents
• B01D 53/62 - Carbon oxides

Abstract

Tridentate platinum, palladium, and gold complexes of Formulas A-I and A-II and tridentate iridium and rhodium compounds of Formulas B-I, B-II, and B-III suitable for delayed fluorescent and phosphorescent or phosphorescent emitters in display and lighting applications. Tridentate platinum, palladium, and gold complexes of Formulas A-I and A-II and tridentate iridium and rhodium compounds of Formulas B-I, B-II, and B-III suitable for delayed fluorescent and phosphorescent or phosphorescent emitters in display and lighting applications.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• C07F 1/12 - Gold compounds
• C07F 9/6568 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
• C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H05B 33/14 - Light sources with substantially two-dimensional radiating surfaces characterised by the chemical or physical composition or the arrangement of the electroluminescent material
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers
• H10K 101/10 - Triplet emission

Abstract

A system and methods are provided for analyzing an object. The method includes collecting image data of the object, where the image data includes a panoramic image capturing at least one entire 360-degree circumferential view of the object. The method also includes cropping the panoramic image to create a prepared image containing a single 360-degree view of the object, processing the prepared image to produce a processed image, and quantifying features of the object via the processed image.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/70 - Determining position or orientation of objects or cameras
• G06T 7/90 - Determination of colour characteristics
• G06T 7/11 - Region-based segmentation
• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06Q 50/02 - AgricultureFishingForestryMining
• H04N 23/951 - Computational photography systems, e.g. light-field imaging systems by using two or more images to influence resolution, frame rate or aspect ratio

Abstract

A nanostructure comprising: a) a base plate sheet comprising a single-duplex layer comprised of DNA origami configured in a planar arrangement, b) a pore configured within the center of the base plate sheet, and c) a multi-duplex layer-thick wall comprising a single-duplex layer comprised of DNA origami that extends downward from the base plate sheet on the periphery of the pore, wherein the base plate sheet comprises a single-stranded DNA region on the bottom surface for lipid membrane anchor modification.

IPC Classes  ?

• C12Q 1/6825 - Nucleic acid detection involving sensors
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

A method and reactor for a hybrid thermo-electrochemical cycle using a layered reactive element is disclosed. The method includes heating the reactive element with a heat source, the reactive element having a metal oxide core that is redox-active, an outer layer, and an ion conductor layer between the core and the outer layer. The method includes increasing a chemical potential of oxygen in the core, driving O2− ions out as O2, the chemical potential increased through applying a first bias voltage between the core and the outer layer. The method includes exposing the reactive element to an input gas, and decreasing the chemical potential of oxygen in the core, driving oxygen from the input gas into the core leaving a gas product, the chemical potential decreased through applying a second bias voltage between the core and the outer layer. The first and second bias voltages have opposite polarity.

IPC Classes  ?

• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• C25B 1/042 - Hydrogen or oxygen by electrolysis of water by electrolysis of steam
• C25B 1/23 - Carbon monoxide or syngas
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 11/067 - Inorganic compound e.g. ITO, silica or titania
• C25B 13/07 - DiaphragmsSpacing elements characterised by the material based on inorganic materials based on ceramics
• C25B 15/021 - Process control or regulation of heating or cooling

Abstract

Carbonized cellulose fiber electrodes for high-frequency electrochemical capacitors and method for fabricating the same is disclosed. The method includes carbonizing a cellulose fiber substrate by subjecting the cellulose fiber substrate to a rapid pyrolysis process in a preheated furnace having an inert environment at a pyrolysis temperature of at least 1000° C., resulting in a carbonized cellulose substrate. The method also includes preparing a hydrothermal solution, and depositing vertically oriented nanoflakes on the carbonized cellulose substrate by immersing the carbonized cellulose substrate in the hydrothermal solution and conducting a hydrothermal reaction, thereby forming the electrode. The vertically oriented nanoflakes may be composed of MoS2. The cellulose fiber substrate may be a cellulose tissue sheet. The electrochemical capacitor includes at least two electrodes, each having vertically oriented nanoflakes deposited on a carbonized cellulose substrate, and an electrolyte positioned between each pair of the at least two electrodes.

IPC Classes  ?

• H01G 4/008 - Selection of materials
• H01G 4/01 - Form of self-supporting electrodes

Abstract

A system for producing gas streams for use in synthetic fuel production through CO2 capture and water splitting is disclosed. The system includes a CO2 capture device configured to receive a CO2-containing stream and including an aqueous alkaline solution. The alkaline solution includes hydroxide and/or carbonate ions. The CO2 capture device generates a carbon-rich solution when the alkaline solution absorbs CO2. The carbon-rich solution includes carbonate and/or bicarbonate ions. The system also includes an electrolyzer fluidically coupled to the CO2 capture device, and defining a volume including an anode region having an anode, and a cathode region having a cathode. The volume includes an electrolyte solution having a pH gradient generated by an electric current, causing the electrolyte solution to be acidic in the anode region and alkaline in the cathode region. The carbon-rich solution is received into the electrolyzer. The electrolyzer generates hydrogen, oxygen, and CO2 streams.

IPC Classes  ?

• B01D 53/96 - Regeneration, reactivation or recycling of reactants
• B01D 53/62 - Carbon oxides
• B01D 53/78 - Liquid phase processes with gas-liquid contact
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 1/50 - Processes
• C25B 9/19 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms
• C25B 15/08 - Supplying or removing reactants or electrolytesRegeneration of electrolytes

Abstract

Provided herein are methods of detecting an African swine fever virus (ASFV) biomarker in a sample. The methods include contacting the sample with a plurality of plasmonic metal nanoparticles (MNPs) that are conjugated with a set of ASFV proteins, or fragments thereof, that comprise an epitope that binds to an anti-ASFV antibody in the sample to produce bound anti-ASFV antibodies, or contacting the sample with a plurality of MNPs that are conjugated with a set of antibodies, or antigen binding portions thereof, that binds to an epitope of an ASFV protein in the sample to produce bound ASFV proteins. The methods also include detecting the ASFV biomarker in the sample when aggregations of the bound anti-ASFV antibodies form with one another or when aggregations of the bound ASFV proteins form with one another. Related compositions, reaction mixtures, devices, kits, and systems are also provided.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

Examples of implementation and training of artificial intelligence models developed with self-supervised learning for medical image analysis are disclosed. The models as trained leverage training from discriminative learning, restorative learning, and adversarial learning in a unified manner to glean complementary visual information from unlabeled medical images for fine-grained semantic representation learning. The models as trained provide features suitable for generalizable representation of medical input images many organs, diseases, and modalities.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

Multi-stage distributed beamforming for distributed mosaic wireless networks is provided. Embodiments described herein present systems, devices, and methods that provide increased range, data rate, and robustness to interference and jamming. A distributed mosaic wireless network includes a transmitter, a receiver, and one or more distributed clusters of radios referred to herein as mosaics or relay mosaics. Each mosaic consists of several distributed, cooperative radio transceivers (e.g., mosaic nodes) that relay a signal sent by the transmitter towards the receiver. In some embodiments, a single-stage beamforming technique is implemented whereby the transmitter sends a signal to a first mosaic, which then relays this signal by beamforming to the receiver. In some embodiments, a multi-stage beamforming technique is implemented whereby the transmitter sends a signal to a first mosaic, which then relays this signal by beamforming to a second mosaic, which then relays this signal by beamforming to the receiver.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04B 1/04 - Circuits
• H04L 1/16 - Arrangements for detecting or preventing errors in the information received by using return channel in which the return channel carries supervisory signals, e.g. repetition request signals
• H04L 25/02 - Baseband systems Details

Abstract

The present disclosure relates to methods for monitoring effectiveness of a treatment of an autism spectrum disorder (ASD) by analyzing an ASD patient's gut microbiota based on stool samples. Also provided are software for implementing the methods, and kits for performing the methods.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

A neuromodulation device is provided that comprises a flexible layer comprising a non-conductive material, in which the layer is positioned in at least a partially tubular shape. The neuromodulation device comprises at least one cathodic band comprising at least one conductive cathodic contact housed by the layer. The neuromodulation device comprises an anodic band comprising at least one anodic contact housed by the layer. The neuromodulation device comprises is configured to receive a wireless signal to power and activate the at least one cathodic contact and the at least one anodic contact in a coordinated reset cycle.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/02 - ElectrotherapyCircuits therefor Details
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/378 - Electrical supply

Abstract

The present invention provides nanoparticles or compositions thereof comprising resveratrol and/or quercetin, or derivatives, prodrugs, or pharmaceutically acceptable salts thereof, at least one lipid, at least one surfactant, and at least one vitamin E. In some embodiments, the nanoparticles or compositions thereof further comprise at least one targeting agent. In some embodiments, the nanoparticles or compositions thereof are targeted for an adipose tissue of interest. In some aspects, the present invention provides methods of activating brown adipose tissue or browning white adipose tissue or beige adipose tissue of interest. In some aspects, the present invention provides methods of reducing body fat, inducing weight loss, and/or improving glucose homeostasis and insulin sensitivity. In some aspects, the present invention provides methods of optimizing the composition of the gut microbiota. In some aspects, the present invention provides methods of treating or preventing various diseases or disorders, such as obesity.

IPC Classes  ?

• A61K 31/05 - Phenols
• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 9/51 - Nanocapsules
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/06 - Antihyperlipidemics
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Systems & methods for sorting single-walled carbon nanotubes (SWNTs) using an iDEP-based sorting device. The device includes an inlet channel with a constriction and the inlet channel splits into multiple different channels after the constriction—the multiple channels includes a center channel and at least one side channel. A sample is introduced into the iDEP sorting device containing a plurality of SWNTs of different lengths suspended in a fluid. An electrical field is applied to the sample between a first electrode in the center channel and a second electrodes at a proximal end of the inlet channel. The applied electrical field causes longer SWNTs to move towards the side channels while the shorter SWNTs move towards the center channel. Accordingly, a first plurality of shorter SWNTs is then collected from the center channel and a second plurality of longer SWNTs is collected from the at least one side channel.

IPC Classes  ?

• C01B 32/172 - Sorting
• B03C 5/02 - Separators

Abstract

Provided herein are methods of differentiating cell types in a cell population. The methods include removing at least some non-Chimeric Antigen Receptor (CAR)-T cells from a fluidic sample obtained from a subject without centrifuging the fluidic sample to produce a purified fluidic sample. The fluidic sample comprises CAR-T cells and the non-CAR-T cells. The methods also include capturing cells in the purified fluidic sample on a surface that comprises binding moieties that bind at least to the CAR-T cells to produce a captured cell population. In addition, the methods also include distinguishing the CAR-T cells from the non-CAR-T cells in the captured cell population using a trained machine learning model to produce a captured CAR-T cell population data set. Additional methods as well as related devices and systems are also provided.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning

Abstract

A composite electrode includes a polypyrrole matrix, and metal nanoparticles coupled to the polypyrrole matrix. Assessing the presence of an analyte includes placing the composite electrode in a solution to be tested for the analyte, applying an electrical current to the electrode, and assessing the presence of an oxidation peak at a predetermined voltage with respect to a reference electrode. The presence of the oxidation peak at the predetermined voltage indicates the presence of the analyte. Fabricating the composite electrode includes electropolymerizing a polypyrrole matrix onto a metal substrate, separating the polypyrrole matrix from the metal substrate, and electrodepositing the metal nanoparticles onto the polypyrrole matrix to yield the electrode.

IPC Classes  ?

• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/48 - Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage

Abstract

Composite material can include a matrix material, a fiber dispersed in the matrix material, and an ultraviolet (UV)-light sensitive mechanophore grafted to a surface of the fiber. A method for making a fiber-reinforced polymer composite can include contacting a fiber in a first solution, rinsing and then drying intermediate fiber, contacting dried fiber in a third solution, rinsing, and then drying the rinsed fiber thereby generating functionalized fiber that is sensitive to ultraviolet light. The functionalized fiber can be combined with a polymer matrix material, cured, and irradiated, thereby generating a fiber-reinforced polymer composite.

IPC Classes  ?

• C08J 5/08 - Reinforcing macromolecular compounds with loose or coherent fibrous material using pretreated fibrous materials glass fibres
• C08J 3/28 - Treatment by wave energy or particle radiation
• C08J 5/04 - Reinforcing macromolecular compounds with loose or coherent fibrous material
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis

Abstract

A system disclosed herein applies a parameterized sensing and localization error model for use by connected devices to improve cooperative sensor fusion by estimating errors using key prediction factors (e.g., distance and velocity) at different tiers. The parameterized sensing and localization error model implements a local sensor fusion process for fusing measurements from sensors of a connected device and a global sensor fusion process for fusing measurements from many connected devices. The local sensor fusion process generates a covariance matrix that incorporates a measured distance and the global sensor fusion process generates a covariance matrix that incorporates a measured velocity combined with the local sensor fusion result. Results show an average improvement of 1.42× in RMSE vs. a typical fixed error model on a 1/10 scale test-bed.

IPC Classes  ?

• B60W 60/00 - Drive control systems specially adapted for autonomous road vehicles
• B60W 50/00 - Details of control systems for road vehicle drive control not related to the control of a particular sub-unit
• H04W 4/44 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for communication between vehicles and infrastructures, e.g. vehicle-to-cloud [V2C] or vehicle-to-home [V2H]

Abstract

Organic light emitting devices (OLEDs) with emissive layers containing both phosphorescent Pt complexes and fluorescent emitters, are described. The devices presented employ both fluorescent and phosphorescent Pt complexes in order to redistribute the excited states to primarily reside on known stable fluorescent emitters to achieve high device operational stability but maintain the high efficiency characteristic of phosphorescent OLEDs.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• H10K 101/00 - Properties of the organic materials covered by group

Abstract

Donor-acceptor type thermally activated delayed fluorescent emitters based on imidazo[1,2-F]phenanthridine and analogues for full color displays and lighting applications.

IPC Classes  ?

• H10K 85/60 - Organic compounds having low molecular weight
• C07D 471/14 - Ortho-condensed systems
• C07D 471/20 - Spiro-condensed systems
• C07D 471/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups in which the condensed systems contains four or more hetero rings
• C07D 491/147 - Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
• C07D 491/22 - Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or in which the condensed system contains four or more hetero rings
• C07D 495/14 - Ortho-condensed systems
• C07D 495/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• H10K 50/11 - OLEDs or polymer light-emitting diodes [PLED] characterised by the electroluminescent [EL] layers

Abstract

A stepwise incremental pre-training for integrating discriminative, restorative, and adversarial learning in an AI model. Exemplary systems include means for receiving a training dataset for training a unified AI model. The unified AI model applies each of discriminative, restorative, and adversarial learning operations through three transferable components: a discriminative encoder, a restorative decoder, and an adversarial encoder. Stepwise incremental pre-training operations train the unified AI model, including pre-training the discriminative encoder via discriminative learning and attaching the trained discriminative encoder with the restorative decoder to form a skip-connected encoder-decoder, pre-training the skip-connected encoder-decoder via joint discriminative and restorative learning, and associating the pre-trained skip-connected encoder-decoder with the adversarial encoder. Training of the AI model is finalized by performing full discriminative, restorative, and adversarial learning on the training dataset using the unified AI model.

IPC Classes  ?

• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
• G06N 3/088 - Non-supervised learning, e.g. competitive learning
• G06N 3/094 - Adversarial learning
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

The present invention provides a method of culturing microorganisms normally grown on a solid in liquid media, methods of use thereof to determine the presence or absence of the microorganism in a sample, and methods of use in a mutation accumulation assay.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

A low-cost robotic shake table and method for operating the same is disclosed. The shake table includes a chassis having a pedestal slidably coupled to two linear shafts. The shake table also includes a motion system having a stepper motor, a transmission, and a motor driver, with the stepper motor coupled to the pedestal through the transmission. The shake table includes a perception system having a camera, an accelerometer coupled to the pedestal, and a plurality of fiducial markers coupled to the pedestal, and a microcontroller communicatively coupled to the motor driver and the perception system. The microcontroller is configured to receive an input motion data, produce a set of translational velocities based upon the input motion data, and convert the set of translational velocities into a control signal that will cause the stepper motor to move the pedestal along the linear shafts according to the translational velocities.

IPC Classes  ?

• G01M 7/02 - Vibration-testing

Abstract

The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neurotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘Prevotella-like enterotype’ compared to neurotypical subjects. The relative abundance of genera Prevotella, Coprococcus, Prevotellaceae and Veillonellaceae are significantly lower in autistic children than in neurotypical children. Further, Prevotella, is one of the three main classifiers for the human enterotypes, along with Bacteriodes and Ruminococcus. These three core genera are among main contributors in the principle component analysis. ‘Prevotella-like enterotype’ was absent in the autistic group, while neurotypical samples showed an even distribution among the three enterotypes. The present disclosure provides for an understanding the association between gut microbiota, health, and disease states, and provides for potential diagnostic and therapeutic targets.

IPC Classes  ?

• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
• A61K 35/741 - Probiotics
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Preparing hybrid-treated plastic particles from waste plastic includes combining waste plastic particles with bio-oil to yield a mixture, irradiating the mixture with microwave radiation to yield oil-treated plastic particles, and contacting the oil-treated plastic particles with carbon-containing nanoparticles to yield hybrid-treated plastic particles. The hybrid-treated plastic particles have a bio-oil modified surface and a coating comprising carbon-containing nanoparticles on the bio-oil modified surface of the plastic particle. In some examples, a diameter of the plastic particle is in a range between 250 μm and 750 μm, and a thickness of the coating is in a range of 1 nm to 20 nm. A modified binder includes an asphalt binder or a concrete binder and a multiplicity of the treated plastic particles. The modified binder typically includes 5 wt % to 25 wt % of the hybrid-treated plastic particles.

IPC Classes  ?

• B29B 9/16 - Auxiliary treatment of granules
• B29B 13/08 - Conditioning or physical treatment of the material to be shaped by using wave energy or particle radiation
• C04B 26/26 - Bituminous materials, e.g. tar, pitch
• C08K 3/04 - Carbon
• C09D 7/61 - Additives non-macromolecular inorganic

Abstract

A fast-tracking phase-locked-loop (PLL) with an analog mixer for phase detection and correction is provided. A frequency lock loop architecture as described herein is used for a PLL that can lock the phase of a local oscillator to an input reference signal of arbitrarily high frequency, even if the local oscillator and the input reference signal frequencies are originally very far apart. To accommodate arbitrarily high frequency input reference signals, embodiments use an analog mixer for the phase detector, rather than a phase-frequency detector (PFD). The analog mixer can be designed to operate on input signals with frequencies of 10's of GHz, whereas the PFD is limited to input frequencies of less than 1 GHz. Embodiments use a new architecture utilizing the concept of Hartley Image Rejection receiver architecture in a frequency lock loop, which enables the PLL to adjust the local oscillator frequency to be brought within the frequency locking range of the analog mixer.

IPC Classes  ?

• H03L 7/087 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal using at least two phase detectors or a frequency and phase detector in the loop
• H03L 7/081 - Details of the phase-locked loop provided with an additional controlled phase shifter
• H03L 7/093 - Details of the phase-locked loop concerning mainly the frequency- or phase-detection arrangement including the filtering or amplification of its output signal using special filtering or amplification characteristics in the loop

Abstract

Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism

Abstract

A method of forming a monocrystalline nitinol film on a single crystal silicon wafer can comprise depositing a first seed layer of a first metal on the single crystal silicon wafer, the first seed layer growing epitaxially on the single crystal silicon wafer in response to the depositing the first seed layer of the first metal; and depositing the monocrystalline nitinol film on a final seed layer, the monocrystalline nitinol film growing epitaxially on the final seed layer in response to the depositing the monocrystalline nitinol film. The method can form a multilayer stack for a micro-electromechanical system MEMS device.

IPC Classes  ?

• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
• B81B 7/00 - Microstructural systems
• C30B 25/06 - Epitaxial-layer growth by reactive sputtering
• C30B 25/18 - Epitaxial-layer growth characterised by the substrate
• C30B 29/52 - Alloys
• C30B 29/68 - Crystals with laminate structure, e.g. "superlattices"

Abstract

Described herein are nucleic acid complexes for the targeted delivery of nucleic acid based prodrug and a nucleic acid based protein degrader which are conditionally activated in the presence of a selected gene target or chemical and biological stimuli. The nucleic acid complexes involve double-stranded DNA, XNA, DNA/XNA/RNA hybrids, and DNA nanostructures (Conditional Proteolysis Gene silencing Targeting Chimera "PROGENTAC").

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12Q 1/6813 - Hybridisation assays
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 35/00 - Antineoplastic agents
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical