Basilea Pharmaceutica International AG, Allschwil

Italy

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IPC Class
A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin 1
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics 1
C07D 501/12 - SeparationPurification 1
C07D 501/54 - Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms 1
Found results for  patents

1.

CRYSTALLINE (6R,7R)-7-{2-(5-AMINO-[1,2,4]THIADIAZOL-3-YL)-2-[(Z)-TRITYLOXYIMINO]-ACETYLAMINO}-3-[(R)-1'-TERT-BUTOXYCARBONYL-2-OXO-[1,3']BIPYRROLIDINYL-(3E)-YLIDENEMETHYL]-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID BENZHYDRYL ESTER; ITS MANUFACTURE AND USE

      
Document Number 02721440
Status In Force
Filing Date 2009-04-14
Open to Public Date 2009-10-22
Grant Date 2012-12-11
Owner BASILEA PHARMACEUTICA INTERNATIONAL AG, ALLSCHWIL (Italy)
Inventor
  • Alpegiani, Marco
  • Cabri, Walter
  • Heubes, Markus
  • Longoni, Davide
  • Schleimer, Michael

Abstract

A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.

IPC Classes  ?

  • A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
  • A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
  • C07D 501/12 - SeparationPurification
  • C07D 501/54 - Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms