Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

IPC Classes  ?

• A61F 2/28 - Bones
• A61L 27/10 - Ceramics or glasses
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

IPC Classes  ?

• A61F 2/28 - Bones
• A61L 27/10 - Ceramics or glasses
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix

Abstract

This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61B 6/03 - Computed tomography [CT]
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

IPC Classes  ?

• A61F 2/28 - Bones
• A61L 27/10 - Ceramics or glasses
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix

Abstract

This invention relates to porous microparticulate carriers that incorporate radioisotopes to form radiomicroparticles for radiation therapy and imaging. The invention also provides methods of preparing the microparticles and methods of treatment using the radiomicroparticles.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C03C 10/04 - Silicate or polysilicate crystalline phase, e.g. mullite, diopside, sphene, plagioclase

Abstract

This invention relates to porous microparticulate carriers that incorporate radioisotopes to form radiomicroparticles for radiation therapy and imaging. The invention also provides methods of preparing the microparticles and methods of treatment using the radiomicroparticles.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61P 35/00 - Antineoplastic agents
• A61K 103/32 - Yttrium
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
• C03C 3/14 - Silica-free oxide glass compositions containing boron
• C03C 12/00 - Powdered glassBead compositions

Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

IPC Classes  ?

• A61F 2/28 - Bones
• A61L 27/10 - Ceramics or glasses
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body

Abstract

This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging.

IPC Classes  ?

• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61B 6/03 - Computed tomography [CT]
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

IPC Classes  ?

• A61F 2/28 - Bones
• C03B 19/06 - Other methods of shaping glass by sintering
• C03C 4/00 - Compositions for glass with special properties
• C03C 11/00 - Multi-cellular glass
• A61L 27/10 - Ceramics or glasses
• A61L 27/56 - Porous or cellular materials
• A61L 31/02 - Inorganic materials
• A61L 31/14 - Materials characterised by their function or physical properties
• A61L 15/08 - Stiffening bandages containing inorganic materials, e.g. plaster of Paris
• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61L 24/02 - Surgical adhesives or cementsAdhesives for colostomy devices containing inorganic materials
• C03B 19/10 - Forming beads
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/58 - Materials at least partially resorbable by the body
• C03B 32/02 - Thermal crystallisation, e.g. for crystallising glass bodies into glass-ceramic articles
• C03C 3/04 - Glass compositions containing silica

Abstract

3 as a principal glass former, BaO, and other components and wherein the glass material is substantially alkali-free and contains less than 30% crystalline material.

IPC Classes  ?

• C03C 3/064 - Glass compositions containing silica with less than 40% silica by weight containing boron
• C03C 8/02 - Frit compositions, i.e. in a powdered or comminuted form
• C03C 8/24 - Fusion seal compositions being frit compositions having non-frit additions, i.e. for use as seals between dissimilar materials, e.g. glass and metalGlass solders
• H01M 8/0282 - Inorganic material
• H01M 2/06 - Arrangements for introducing electric connectors into or through cases
• C03C 8/04 - Frit compositions, i.e. in a powdered or comminuted form containing zinc
• C03C 3/066 - Glass compositions containing silica with less than 40% silica by weight containing boron containing zinc
• C03C 3/068 - Glass compositions containing silica with less than 40% silica by weight containing boron containing rare earths
• H01M 8/02 - Fuel cellsManufacture thereof Details
• H01M 8/12 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte

Abstract

This invention relates to a method for making strontium-phosphate microparticles that incorporate radioisotopes for radiation therapy and imaging.

IPC Classes  ?

• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Abstract

This invention relates to strontium-phosphate microparticles that incorporate radioisotopes for radiation therapy and imaging.

IPC Classes  ?

• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
• C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium

Abstract

This invention relates to strontium-phosphate microparticles that incorporate radioisotopes for radiation therapy and imaging.

IPC Classes  ?

• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• A61M 36/14 - Radioactive dressings
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment

Abstract

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

IPC Classes  ?

• A61F 2/28 - Bones
• A61L 27/10 - Ceramics or glasses
• A61L 27/12 - Phosphorus-containing materials, e.g. apatite
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 27/58 - Materials at least partially resorbable by the body
• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix

Abstract

A sealant for forming a seal between at least two solid oxide fuel cell components wherein the sealant comprises a glass material comprising B2O3 as a principal glass former, BaO, and other components and wherein the glass material is substantially alkali-free and contains less than 30% crystalline material.

IPC Classes  ?

• H01M 2/06 - Arrangements for introducing electric connectors into or through cases
• H01M 2/08 - Sealing materials
• C03C 3/064 - Glass compositions containing silica with less than 40% silica by weight containing boron

Abstract

This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.

IPC Classes  ?

• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes