Abstract

Disclosed herein are capped RNA molecules comprising one or more modified nucleotides at position +3 or higher with reference to a 5' terminus of the RNA molecule, and methods of making the same. The capped RNA molecules may be made by ligating a 5'-capped modified RNA oligonucleotide to the 3' terminus of an RNA molecule. Also provided are compositions comprising one or more of the capped RNA molecules provided herein, and methods of using said compositions for therapeutic applications, such as in the treatment or prevention of a disease in a subject, such as SARS-CoV-2.

IPC Classes  ?

• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/86 - Viral vectors

Abstract

Linear time-invariant (LTI) filters are a staple of modern signal processing. LTI filters perform many operations including signal estimation, bandpass/ stopband selection, encoding/decoding, modulation/demodulation, etc. Most modem LTI filters operate in the digital domain due to the flexibility of programming digital processors. However, this means that the incoming signal must be digitized. This introduces the signals to the bottlenecks and latency of digital computing, where digital electronics cannot process the increasing high data-rate and high-bandwidth data in dense spectral environments in real-time. The programmable analog LTI (PA-LTI) architecture is a hardware accelerator that performs real-time LTI operations in the analog domain and is fully programmable, enabling unprecedented acceleration of front-end PHY layer communications processing. Conventional analog LTI processors, such as RLC circuits or amplifiers, can perform only one LTI function. A PA-LTI processor can be digitally programmed to implement any arbitrary finite impulse response (FIR) LTI operation in the analog domain.

IPC Classes  ?

• H04B 1/10 - Means associated with receiver for limiting or suppressing noise or interference
• H03H 21/00 - Adaptive networks
• H03H 11/12 - Frequency selective two-port networks using amplifiers with feedback
• H03H 11/04 - Frequency selective two-port networks
• H03H 15/02 - Transversal filters using analogue shift registers

Abstract

222/CO mixture to methanol using the electrode.

IPC Classes  ?

• C25B 3/07 - Oxygen containing compounds
• C25B 3/26 - Reduction of carbon dioxide
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/065 - Carbon
• C25B 11/085 - Organic compound

Abstract

232222 gas onto ultramafic rocks; and 3) collection and separation of percolated fluid form water- ultramafic rocks to extract valuable trace elements therefrom. The integrated system can deliver reactants through a subsurface for reaction with rocks disposed below ground, and outlets for collecting the products from the earth.

IPC Classes  ?

• C01B 3/02 - Production of hydrogen or of gaseous mixtures containing hydrogen
• C01B 3/04 - Production of hydrogen or of gaseous mixtures containing hydrogen by decomposition of inorganic compounds, e.g. ammonia
• C01B 3/06 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents

Abstract

In a method for transferring van der Waals materials, a van der Waals material is grown on or transferred onto a source substrate. A support layer is adhered to the van der Waals material. The source substrate with the van der Waals material is then immersed in a weak base solution, producing an electrical double layer at and between surfaces of (a) the van der Waals material and (b) the source substrate, wherein the electrical double layers generate a repulsive force that detaches the van der Waals material from the source substrate. The support layer with the adhered van der Waals material is separated from the source substrate. The support layer with the adhered van der Waals material is then applied to a target substrate. The support layer is then removed from the van der Waals material, leaving the van der Waals material adhered to the target substrate.

IPC Classes  ?

• B32B 37/02 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by a sequence of laminating steps, e.g. by adding new layers at consecutive laminating stations
• B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate

Abstract

A computer-implemented method determines distribution of one or more amino acids in a cellular condensate. At least one perceptron layer to a protein language model. The at least one perceptron layer adapts the protein language model for predicting a probability of distribution of an amino acid sequence into a cellular condensate, thereby producing a modified protein language model. The modified protein language model is trained on a training dataset, which is a plurality of training amino acid sequences, each of which is annotated with one or more cellular condensates into which it partitions, thereby generating a trained protein language model. A test dataset of one or more test amino acid sequences can be applied to the trained protein language model to determine probability of partitioning of the one or more test amino acid sequences in the cellular condensate.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 40/20 - Supervised data analysis

Abstract

A method, carried out by one or more processing devices, is used for mapping cells on Earth that contain communications terminals to communications spacecraft or aircraft, as appropriate, referred to as satellite routing. The method comprises: grouping the cells into groups or clusters by applying clustering techniques; mapping the groups of cells to spacecraft or aircraft; and outputting parameters usable to control at least one spacecraft or aircraft to provide service to the assigned cells. The invention also relates to a system, computer program products, and a method and system for simulating a satellite routing.

Abstract

Geologic hydrogen production and related systems and methods are generally described.

IPC Classes  ?

• C01B 3/06 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents
• E21B 43/16 - Enhanced recovery methods for obtaining hydrocarbons
• E21B 43/26 - Methods for stimulating production by forming crevices or fractures

Abstract

22). Some aspects are related to electrocatalysts comprising copper nanoparticles having shapes and/or compositions that may desirably affect their electrocatalytic performance, for instance, the related faradaic efficiencies and/or product distributions obtained during electrocatalysis using the nanoparticles. Still other aspects are generally directed to related methods of making and/or using the electrocatalysts and/or systems.

IPC Classes  ?

• H01M 4/12 - Processes of manufacture of consumable metal or alloy electrodes
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A robotic system has a hand with multiple finger whose state is controllable by a controller, an imaging device for providing depth images of the hand and objects held by the hand, and the controller. The controller implements a policy computation for processing data determined from depth images of an object held by the hand to provide commands for the hand to reorient the object held in the hand while maintaining support of the object during the reorientation. A training system determines values of configurable parameters of the policy computation module by processing data representing simulated manipulation of a plurality of shapes of objects by the hand, for example, using a reinforcement learning procedure.

Abstract

The disclosure provides apparatus and methods related to the assessment of the fragility and/or deformability of cells, comprising applying negative pressure to an interior volume defined by a hollow member that comprises a fenestration, wherein the negative pressure is sufficient to(1 ) partially aspirate a cell into the interior volume of the hollow member through the fenestration at a time to, and (2) following to, rupture the cell at a time tr, resulting in the complete aspiration of the cell into the interior volume of the hollow member, and measuring a time to rupture of the cell (T) between tr and to. The apparatus and methods provided herein use small sample volumes and provide improved sensitivity and reproducibility over existing methods of assessing cell fragility and/or deformability. The apparatus and methods provided herein are useful for, e.g., evaluating the quality of stored blood to facilitate decisions regarding transfusion and diagnosing a disease, disorder, or condition.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Fluidic devices and programmable fluidic systems, which mimic fluid flow mechanisms found in biological systems are described herein. Methods of using and making such devices and systems are also disclosed.

IPC Classes  ?

• B01F 27/21 - Mixers with rotary stirring devices in fixed receptaclesKneaders characterised by their rotating shafts
• B01F 27/23 - Mixers with rotary stirring devices in fixed receptaclesKneaders characterised by the orientation or disposition of the rotor axis
• B01F 27/85 - Mixers with rotary stirring devices in fixed receptaclesKneaders with stirrers rotating about a substantially vertical axis with two or more stirrers on separate shafts
• F04D 29/20 - Mounting rotors on shafts
• B01F 27/806 - Mixers with rotary stirring devices in fixed receptaclesKneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative positionMeans for fixing the receptacle with vertical displacement of the stirrer, e.g. in combination with means for pivoting the stirrer about a vertical axis in order to co-operate with different receptacles
• B01F 27/2124 - Shafts with adjustable length, e.g. telescopic shafts

Abstract

Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal (GI) tract, but traditional vaccination strategies typically elicit little or no mucosal antibody responses. Disclosed herein is a vaccine comprising a nanoemulsion and an immunogen non-covalently conjugated to the surface of the nanoemulsion by an amphiphilic linker, wherein the vaccine is suitable for inducing a mucosal antibody response in the gastrointestinal tract. Also disclosed are methods of using the vaccine to immunize a subject by intraperitoneal administration of an effective amount of the vaccine, alone or with an adjuvant.

IPC Classes  ?

• A61K 9/10 - DispersionsEmulsions
• A61K 39/39 - Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/51 - Nanocapsules
• C08G 69/10 - Alpha-amino-carboxylic acids

Abstract

Pharmaceutical compositions are disclosed. The pharmaceutical compositions include an antimicrobial compound. The compositions can also include a pharmaceutically acceptable carrier. Discovery methods for discovery of antimicrobial compounds are also disclosed. The discovery methods employ a trained machine learning model to identify substructures of chemical compounds that are predicted to exhibit antimicrobial activity. Antimicrobial activity of known compounds can be discovered and antimicrobial compounds with identified substructures can be generated and/or synthesized.

IPC Classes  ?

• A61P 31/04 - Antibacterial agents
• C07D 207/14 - Nitrogen atoms not forming part of a nitro radical
• G06N 3/00 - Computing arrangements based on biological models

Abstract

Some aspects are generally related to electrocatalysts, for example, for use during electrocatalysis. In some embodiments, the electrocatalysts may be included in a system configured to perform electrocatalysis. For instance, a system may include an electrode that is associated with a first oligo- or polynucleotide and an electrocatalyst that is associated with a second oligo- or polynucleotide. According to some such embodiments, the first and second oligo- or polynucleotides may at least partially base pair and substantially tether the electrocatalyst to the electrode. In some cases, the electrocatalyst comprises nanoparticles comprising copper (Cu), which may be suitable to be configured in a system for the electrocatalytic reduction of carbon dioxide (CO2). Some aspects are related to electrocatalysts comprising copper nanoparticles having shapes and/or compositions that may desirably affect their electrocatalytic performance, for instance, the related faradaic efficiencies and/or product distributions obtained during electrocatalysis using the nanoparticles. Still other aspects are generally directed to related methods of making and/or using the electrocatalysts and/or systems.

IPC Classes  ?

• B22F 9/00 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• C01G 3/00 - Compounds of copper

Abstract

Surface modification of nanoparticles (NPs) via the layer-by-layer (LbL) technique is a approach to generate targeted drug delivery vehicles. A simple and scalable synthesis method for LbL-NPs that can be adapted for clinical translation is of great interest. Presented herein is a robust and scalable method of polymer deposition onto nanoparticles.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• A61K 31/74 - Synthetic polymeric materials

Abstract

Compositions, articles, and methods related to batteries (e.g., sodium-ion batteries) including carbon nanostructure (e.g., carbon nanotube) composites are generally described. In certain embodiments, a composite comprises: (i) an electrochemically active material comprising a bis-tetraamino-benzoquinone molecule and/or a dimer, tautomer, oligomer, polymer, and/or derivative thereof; and (ii) at least one carbon nanotube (CNT). In some embodiments, the composite may be suitable for use as an electrode and/or an electrode material in an electrochemical cell. In certain embodiments, the electrochemical cell is a battery (e.g., a rechargeable battery, such as a sodium-ion battery).

IPC Classes  ?

• H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds
• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/583 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx

Abstract

Systems and methods are disclosed for high torque density mechanical couplings with variable slip control. The disclosed couplings can achieve order-of-magnitude (∼10x) improvements in torque density over existing magnetic and fluid options by leveraging combined normal, frictional, and inertial forces acting on sliding mechanical elements to transmit torque. The disclosed couplings can allow for continuous modulation of high-torque loads while naturally achieving lockup at maximum engagement and remaining well-suited to forced-convection cooling in high-heat-dissipation scenarios. Additionally, the disclosed couplings can be configured to achieve "one-way clutching" behavior while retaining the ability to speed-synchronize (transmit load under partial slip) and achieve lockup. These characteristics make the disclosed couplings well suited to a variety of applications and fields, including automotive and mobile robotics applications, such as active control of vehicle differential slip, where high torque density and slip control are both of critical importance.

IPC Classes  ?

• B60B 35/12 - Torque-transmitting axles
• F16D 3/50 - Yielding couplings, i.e. with means permitting movement between the connected parts during the drive with the coupling parts connected by one or more intermediate members
• F16H 13/06 - Gearing for conveying rotary motion with constant gear ratio by friction between rotary members with members having orbital motion
• F16D 3/00 - Yielding couplings, i.e. with means permitting movement between the connected parts during the drive
• F16H 55/32 - Friction members

Abstract

This disclosure provides a device for assessing forces in tissues and methods of use thereof. The device may be used, for instance, to probe forces associated with characteristics to regulate spatial displacement of a tissue in one or more directions. The device may have at least two rigid attachment points for supporting a tissue and connected to a compliant mechanism to allow displacement of a tissue in a direction x, wherein tissue displacement is constrained in at least one direction other than x. The device may have a compliant mechanism with a stiffness value in a displacement direction that is lower than a stiffness value of the tissue in the displacement direction and/or at least one of the rigid attachment points having a stiffness value in the displacement direction that is higher than a stiffness value of the tissue in the displacement direction.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/22 - ErgometryMeasuring muscular strength or the force of a muscular blow

Abstract

Electrochemical cells (e.g., batteries) that operate across extreme temperatures (e.g., greater than or equal to 50 °C and/or less than or equal to 0 °C), and related methods, are generally described.

IPC Classes  ?

• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 10/052 - Li-accumulators
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

The techniques described herein relate to secure large language models. An example method includes training at least one pre-trained model using training data to generate a set of parameters for configuring portion(s) of the at least one pre-trained model to generate an output associated with the training data, generating data association(s) of one or more users and the set of parameters, performing the above among different sets of training data to generate a plurality of sets of parameters, each of which corresponding to a different one of the different sets of training data, and for at least one user of the user(s), identifying, by using the data association(s), one or more of the sets of parameters that correspond to the at least one user, and generating a trained model for the at least one user based on a combination of the at least one pre-trained model and the identified parameters.

Abstract

Disclosed herein are methods of modular construction of 0D-state tunnel junction devices and methods of use thereof.

IPC Classes  ?

• H10N 60/10 - Junction-based devices
• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H10H 20/811 - Bodies having quantum effect structures or superlattices, e.g. tunnel junctions
• G06N 10/00 - Quantum computing, i.e. information processing based on quantum-mechanical phenomena

Abstract

A method of synthetizing a photonic crystal is disclosed. The method uses nanoparticles to seed the creation of siloxane-based nanoparticles, having a diameter as small as 20 nm. The seed nanoparticles may be gold nanoparticles and the silane may be 3-(trimethoxysilyl)propyl methacrylate (TPM). These siloxane-based nanoparticles are separated from a basic solution and are used to create the photonic crystal. This may be achieved using drop casting, centrifugation or another method. The siloxane-based nanoparticles are then assembled into a photonic crystal. The photonic crystal may reflect light in the visible spectrum in an angle independent manner.

IPC Classes  ?

• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G02B 1/02 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of crystals, e.g. rock-salt, semiconductors
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements

Abstract

The present disclosure is directed to systems, devices, and methods for electrodialysis-based home-scale water desalination. The system can include an electrodialysis (ED) stack that includes a separately disposed electrode rinse stream that is in a closed-loop configuration with the ED stack. The electrode rinse stream can flow from a separate rinse storage vessel and can, optionally, include an auxiliary pump dedicated to pumping the electrode rinse to the ED stack. The ED stack can include one or more compression molded spacers disposed between the electrodes and membranes thereof and endcapend caps on the periphery of the ED stack to reduce a volume of the system to allow for point of use operation. The system and its components can be packaged within dimensions of a reverse osmosis cabinet, which can provide for in-home installation and use.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 1/461 - Treatment of water, waste water, or sewage by electrochemical methods by electrolysis

Abstract

The present disclosure relates to RNAi DNA oligonucleotides for the suppression of an immune response and use in methods of one step construction of allogenic CAR cells capable of avoiding a host rejection.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells

Abstract

Disclosed herein is a sensor, comprising a cable structure having a plurality of cords stitched together in a crown sinnet configuration and at least one conductive element integrated into the cable structure to form a plurality of loops. At least two different loops of the plurality can contact each other in response to a geometric change in the cable structure, thereby changing a resistance of the conductive element. In some embodiments, the geometric change is caused by at least one of a: tension of the cable structure; compression of the cable structure; or bending of the cable structure.

IPC Classes  ?

• G01B 7/16 - Measuring arrangements characterised by the use of electric or magnetic techniques for measuring the deformation in a solid, e.g. by resistance strain gauge
• B32B 5/12 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments characterised by the relative arrangement of fibres or filaments of adjacent layers
• D02G 3/40 - Yarns in which fibres are united by adhesivesImpregnated yarns or threads

Abstract

Disclosed are methods of modulating the surface acidity of a catalyst and methods of catalyzing chemical reactions with a modified catalyst. Also disclosed are methods and reactors for catalyzing chemical reactions with catalysts having modulated surface acidity.

Abstract

Embodiments of the present disclosure are directed towards a heterogenous catalyst composition formed from using a crystalline porous metal-organic framework (MOF) that reacts in an inverse electron-demand Diels-Alder reaction with a phosphorous ligand to produce a heterogeneous catalyst precursor. The heterogeneous catalyst precursor can react with a Group VIII transition metal catalyst precursor compound to form the heterogeneous catalyst composition that can be used for the hydroformylation of olefins, among other reactions.

IPC Classes  ?

• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• B01J 31/24 - Phosphines
• C07C 45/50 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reaction with carbon monoxide by oxo-reactions
• C07C 47/02 - Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony

Abstract

Disclosed are compositions, kits, systems, and methods for treating or healing a wound. The compositions can include a carrier composition with a gas-entrapping material and a gas entrapped within the carrier composition.

IPC Classes  ?

• A61K 33/00 - Medicinal preparations containing inorganic active ingredients
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

This disclosure provides novel integrases for site-specific genetic engineering. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with the novel integrases.

IPC Classes  ?

• C12N 9/22 - Ribonucleases

Abstract

Provided herein are zwitterionic polymer (ZIP)-lipids and pharmaceutically-acceptable salts thereof; lipid nanoparticles (LNPs) comprising such ZIP-lipids; formulations comprising ZIP-lipid containing LNPs; methods of delivering ZIP-lipid containing LNPs, or formulations thereof, to a subject; and methods of treating a disease, dirsorder or condition comprising administering ZIP-lipid containing LNPs, or formulations thereof, to a subject.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61P 11/00 - Drugs for disorders of the respiratory system
• C08F 265/10 - Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group on to polymers of amides or imides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links

Abstract

Existing clinically adopted epicardial pacing leads mostly rely on surgical suturing or insertion of electrodes to the heart tissue. However, these approaches can cause tissue trauma during application and/or retrieval of the implants, potentially causing detrimental complications such as bleeding, tissue damage, and/or device failure. The present invention reports a bioadhesive epicardial pacing lead for atraumatic epicardial monitoring and stimulation of the heart in vivo to overcome the limitations of existing bioelectronic implants. The bioadhesive pacing lead is composed of an insulation layer, a conductive bioadhesive interface, a built-in reservoir, an electrode lead wire, and a fluidic channel. The bioadhesive pacing lead shows robust mechanical and electrical properties, biocompatibility, continuous epicardial monitoring and pacing capability, and rapid on-demand atraumatic employment and removal.

IPC Classes  ?

• A61L 31/14 - Materials characterised by their function or physical properties
• A61N 1/362 - Heart stimulators

Abstract

e.g.e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.

IPC Classes  ?

• A61K 38/39 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• C08G 75/04 - Polythioethers from mercapto compounds or metallic derivatives thereof
• C08G 75/12 - Polythioether-ethers
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• A61L 27/52 - Hydrogels or hydrocolloids

Abstract

Disclosed herein are compounds (e.g, compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, isotopically labeled compounds, and prodrugs thereof), and pharmaceutical compositions, kits, methods, and uses thereof. The compounds disclosed herein are inhibitors of TOX protein and are useful for treating diseases (e.g., immune diseases, proliferative diseases, and viral infections).

IPC Classes  ?

• A61P 31/12 - Antivirals
• A61P 35/00 - Antineoplastic agents
• A61P 37/00 - Drugs for immunological or allergic disorders
• C07D 221/16 - Ring systems of three rings containing carbocyclic rings other than six-membered
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 405/04 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 409/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/435 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom

Abstract

e.g.e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases).

IPC Classes  ?

• C07C 237/22 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• A61K 9/51 - Nanocapsules
• C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Abstract

Methods and systems for evaluating performance of classifier models trained on noisy labels. Using predicted labels for a classifier model, noisy labels, and parameters of the model, a probability of detection and/or a probability of false alarm are determined. Additional predicted labels and/or additional correct labels may also be used to determine the probabilities. A performance evaluation of the trained classifier model is output based on the at least one of the representation of the probability of detection and/or the representation of the probability of false alarm. Using the performance evaluation, it may be determined whether to deploy or undeploy the trained classifier model. Classifier models may be deployed to a classification environment where input data for a classifier model is received and one or more labels are applied to the input data using the classifier model.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

Epitaxial growth of crystalline materials using confined directional growth and related articles and systems are generally described.

IPC Classes  ?

• C30B 25/04 - Pattern deposit, e.g. by using masks
• C30B 29/02 - Elements
• C30B 29/16 - Oxides
• C30B 29/40 - AIIIBV compounds
• C30B 29/46 - Sulfur-, selenium- or tellurium-containing compounds

Abstract

A method and device for stimulating cerebrospinal fluid flow is disclosed. The method may include acquiring an electroencephalography (EEG) signal from a human subject, predicting a target feature of the EEG based on the EEG signal, and playing an auditory stimulus to coincide with the target feature of the EEG learned by a neural network. The target feature may include a peak of a slow wave. The method may include using a recurrent neural network to predict the target feature for a human subject.

IPC Classes  ?

• A61B 5/372 - Analysis of electroencephalograms
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

ABSTRACT Systems and methods for treating neurological disorders, such as epilepsy, where a drug delivery device is implanted adjacent to a micro-region within the brain for local administration of a drug thereto, where local administration of the drug into the micro-region is effective to treat the neurological disorder while substantially avoiding adverse side effects.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61P 25/08 - AntiepilepticsAnticonvulsants
• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis

Abstract

Disclosed herein are everting devices including flexible inflatable structures configured to safely and efficiently lift a subject or other object from a supporting surface. In some embodiments, a flexible inflatable structure may be configured to form a sling used to lift a subject or other object. In other embodiments, everting devices may include end effectors that are everted through an internal channel of a flexible inflatable structure to an exterior everted portion of the flexible inflatable structure as the everting device is transitioned to the fully everted configuration. In other embodiments, a wheelchair may include an everting device with a flexible inflatable structure that is configured to form at least a portion of a seat of the wheelchair in the everted configuration.

IPC Classes  ?

• A61G 7/10 - Devices for lifting patients or disabled persons, e.g. special adaptations of hoists thereto

Abstract

Electrostatic catalysis in chemical synthesis is known to boost reaction rates and selectively produce certain reaction products. Earlier studies required external electric field (EEF) of more than 10 MV/cm and alignment of EEF with the reaction axis. Such large and oriented EEF is unfeasible for large-scale implementation. Disclosed herein is a method of spontaneously shifting the band energy at the tip of an individual single-walled carbon nanotube (SWCNT) in a high-permittivity growth environment, with its other end in contact with a low work function electrode, such as hafnium carbide or titanium carbide. By adjusting the band energy at a point where there is a substantial disparity in the density of states (DOS) between semiconducting (s-) and metallic (m-) SWCNTs, effective electrostatic catalysis for s-SWCNT growth is achieved. The disclosed method enables the production of high-purity (99.92%) s-SWCNT horizontal arrays with stable chirality twist, aided by weak EEF as a perturbation.

IPC Classes  ?

• C01B 32/159 - Carbon nanotubes single-walled
• C01B 32/162 - Preparation characterised by catalysts
• C01B 32/164 - Preparation involving continuous processes
• C01B 32/168 - After-treatment
• D01F 11/16 - Chemical after-treatment of man-made filaments or the like during manufacture of carbon by physicochemical methods
• D01F 9/12 - Carbon filamentsApparatus specially adapted for the manufacture thereof

Abstract

Methods, articles, and systems involving the removal of material from surfaces are generally described.

IPC Classes  ?

• C12M 1/26 - Inoculator or sampler
• C12M 1/00 - Apparatus for enzymology or microbiology
• C25F 1/00 - Electrolytic cleaning, degreasing, pickling, or descaling

Abstract

The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., de-myelinating disease, neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy).

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61N 5/06 - Radiation therapy using light
• C12N 15/86 - Viral vectors
• C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Current measurements for avalanche forecasting are usually taken by digging snow pits or probing. These methods are mostly either fast and qualitative or slow and quantitative. The method disclosed herein offers an approach that is both fast and quantitative and could be useful to backcountry skiers and ski patrollers. The air-dropped system disclosed herein would also be useful for characterizing snow water content, which is useful for estimating city water supplies, particularly in draught-stricken places. Existing ways of measuring sown water content involve taking precise density measurements in particular locations, but these air-dropped techniques could be performed over a much wider area to get a better idea of the distribution of the water content, leading to better estimates of city water supply.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• B64U 10/00 - Type of UAV
• G01D 21/02 - Measuring two or more variables by means not covered by a single other subclass
• G01K 1/14 - SupportsFastening devicesArrangements for mounting thermometers in particular locations

Abstract

Nanoelectronic devices and bioelectronic hybrids thereof are described herein. Methods of making and using such devices and hybrids are also described. The nanoelectronic devices and bioelectronic hybrids can be used, for example, in medical applications. For example, the bioelectronic hybrids can be non-surgically implanted to provide stimulation or modulation to a target site or region in a subject.

IPC Classes  ?

• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Abstract

The invention relates to a method for producing a stacked structure comprising a layer of semiconductor material bonded to a substrate, which comprises: producing a heterostructure by: • forming an intermediate layer made of a two-dimensional material on a growth substrate (1); patterning the intermediate layer with a plurality of openings to form a patterned intermediate layer (3); growing a semiconductor material on the patterned intermediate layer (3) by epitaxial lateral overgrowth to form a continuous epitaxial layer (4) on the patterned intermediate layer; forming a first assembly by bonding the heterostructure to a handling substrate (6), the continuous epitaxial layer being located at the bonding interface; separating the first assembly at the patterned intermediate layer (3) so as to obtain a second assembly resulting from transferring the continuous epitaxial layer (4) from the heterostructure to the handling substrate (6).

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• H01L 21/18 - Manufacture or treatment of semiconductor devices or of parts thereof the devices having potential barriers, e.g. a PN junction, depletion layer or carrier concentration layer the devices having semiconductor bodies comprising elements of Group IV of the Periodic Table or AIIIBV compounds with or without impurities, e.g. doping materials
• H01L 21/762 - Dielectric regions

Abstract

The determination of chemical mixture components is vital to a multitude of scientific fields. Oftentimes various spectroscopic methods are employed to decipher the molecular composition of these complex mixtures. The sheer density of spectral features of different molecules present in such observations may make unambiguous assignment to individual species using these methods challenging. Yet, components of a mixture are commonly chemically related due to environmental processes or shared precursor molecules. Therefore, along with investigating the spectroscopic signals, analysis of the structural and chemical relevance of a molecule is an important consideration when determining which species are present in a mixture. Machine-learning molecular embedding methods are used with a relevance module to determine the likelihood of a molecule being present in a mixture based on the other known species, chemical priors, and spectroscopic information. By incorporating this metric, the mixture components can be identified with extremely high accuracy (∼ 97%).

IPC Classes  ?

• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01R 33/46 - NMR spectroscopy
• G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Abstract

The invention provides methods for diagnosing eosinophilic esophagitis (EoE) in a subject and methods for determining an EoE state (active or remission) in a subject. The methods include detecting elevated expression levels of GPR15 protein or a fragment thereof and/or CD38 protein or a fragment thereof in a biological sample from the subject. Panels, compositions, and kits are also provided.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Abstract

A novel sustainable prefabricated foundation design is presented that is, preferably, intended to be made entirely of polymers (e.g., recycled thermoplastic polymers such as polyethylene terephthalate (PET)).

IPC Classes  ?

• E02D 27/02 - Flat foundations without substantial excavation

Abstract

Systems, apparatuses, and methods for providing a human-computer interface include and/or implement a wearable imaging probe configured to image an internal structure of a body of a wearer; and a memory storing a machine learning algorithm, wherein the machine learning algorithm is configured to receive an imaging data from the wearable imaging probe and determine a pose of the wearer based on the imaging data.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06N 20/00 - Machine learning
• G06F 1/16 - Constructional details or arrangements
• G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
• G06V 10/143 - Sensing or illuminating at different wavelengths
• G06V 40/20 - Movements or behaviour, e.g. gesture recognition

Abstract

Disclosed herein are lanthanide-doped upconverting nanoparticles and methods of making the same. Also disclosed are methods of imaging target proteins and methods of performing single particle tracking comprising the upconverting nanoparticles of this disclosure.

IPC Classes  ?

• C09K 11/77 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing rare earth metals
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• A61K 47/02 - Inorganic compounds
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 49/00 - Preparations for testing in vivo
• C01F 17/36 - Compounds containing rare earth metals and at least one element other than a rare earth metal, oxygen or hydrogen, e.g. La4S3Br6 halogen being the only anion, e.g. NaYF4
• G01N 21/64 - FluorescencePhosphorescence
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Abstract

Described is a frequency multiplier inverter and related systems and techniques.

IPC Classes  ?

• H02M 3/00 - Conversion of DC power input into DC power output
• H02M 7/516 - Self-oscillating arrangements

Abstract

Methods for inhibiting, reducing, or stopping the growth of central nervous system cancers, such as brain tumors, or cancers influenced by the nervous system are described herein. The methods also include, in some instances, reducing or maintaining the size or volume of such cancers. Such methods are useful for treating and combatting aggressive brain cancers.

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 2/00 - Magnetotherapy
• A61N 1/20 - Applying electric currents by contact electrodes continuous direct currents

Abstract

Disclosed herein are modified RNAs comprising region-specific nucleotide modifications, and methods of making the same. Also disclosed are DNA-RNA-DNA (DRD) hybrid polynucleotides and methods of making the same. The modified RNAs and DRD hybrid polynucleotides may be made by phased extension of a primer annealed to one or more single stranded DNA templates using multiple distinct mixtures of nucleotide triphosphates. Also provided are compositions comprising one or more of the modified RNAs or DRD hybrid polynucleotides provided herein, and methods of using said compositions for therapeutic applications.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

Disclosed is a method of detecting and/or quantifying a paramagnetic metal ion in a sample, comprising: (a) preparing the sample containing the paramagnetic metal ion in a hydrochloric acid, or a nitric acid, or a perchloric acid solution; and (b) establishing a standard curve between a relaxation rate R1 (or R2) and a standard paramagnetic metal ion concentration, using a Micromagnetic Resonance Relaxometry (MRR) device; (c) determining the R1 (or R2) of the sample and quantifying the paramagnetic metal ion according to the standard curve; wherein the concentration of the paramagnetic metal ion is at least 0.1 µM. Also disclosed is a method of identifying a risk of a disease, diagnosing a disease, or monitoring status of a disease in a patient, wherein the disease is associated with an amount of a paramagnetic metal ion in the patient, comprising the paramagnetic metal ion detecting and/or quantifying method as disclosed herein.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01R 33/465 - NMR spectroscopy applied to biological material, e.g. in vitro testing
• G01R 33/50 - NMR imaging systems based on the determination of relaxation times

Abstract

The technology is directed to transgene constructs that use at least one intron to provide interspecies biocontainment. The transgene construct can comprise a polypeptide coding sequence interrupted by at least one heterologous intron sequence. Also described herein are nucleic acids, pharmaceutical compositions, and preparations comprising such transgene constructs. Method of uses of such transgene constructs and associated compositions are also disclosed herein.

IPC Classes  ?

• A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

A pair of metasurfaces are used in a microendoscope to provide imaging over a 172° field-of-view with a depth-of-focus extending from 0.3 mm to >300 mm. The range of operating wavelength can be from 450 nm to 1550 nm. The resolution of the microendoscope can be as fine as 115 line-pairs per mm. The dimensions of the microendoscope's meta-optical imager can be as small as approximately 1 mm x 1 mm x 1 mm.

IPC Classes  ?

• G02B 23/24 - Instruments for viewing the inside of hollow bodies, e.g. fibrescopes
• H04N 23/958 - Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging
• A61B 1/045 - Control thereof
• G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements

Abstract

The present disclosure relates to a CROPseq-multi vector for multiplexed perturbation and decoding in pooled genetic screens. The present disclosure also relates to multiplexed perturbation and decoding for optical pooled screens with the CROPseq-multi vector. The CROPseq-multi vector provides a universal solution for multiplexed perturbation and decoding in pooled screens.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay

Abstract

The present disclosure provides, among other things, a copolymer, wherein the copolymer comprises: a first block comprising diketopyrrolopyrrole; and a second block comprising thiophene functionalized with a polar side group. Also disclosed herein are compositions and sensors comprising the copolymer, and methods of detecting an analyte, the methods comprising: contacting a sensor of the present disclosure with a sample comprising the analyte; and measuring an electrical property of the sensor in contact with the sample.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• C07D 333/10 - Thiophene
• C08F 32/08 - Homopolymers or copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
• F02M 26/46 - Sensors specially adapted for EGR systems for determining the characteristics of gases, e.g. composition
• G01D 21/00 - Measuring or testing not otherwise provided for

Abstract

Compounds which effect the Complement cascade by, for example, inhibition of the C3aR receptor are provided. The compound may have the structure of Formula (I). The disclosure further provides methods of use of these compounds, kits and compositions comprising these compounds, and synthetic methods involving these compounds.

IPC Classes  ?

• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 231/38 - Nitrogen atoms
• C07D 471/04 - Ortho-condensed systems
• A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Abstract

22) and an excited-state photoacid (e.g., an organic excited-state photoacid such as pyranine), such that a proton activity of at least a portion of the solution (e.g., proximal to a liquid-gas interface and/or a liquid-solid interface) is increased, wherein the increase in the proton activity induces, at least in part, one or more reactions resulting in at least some of the dissolved target species molecules changing to a gaseous state.

IPC Classes  ?

• B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption

Abstract

Local quantum communication networks for general-purpose quantum computing may use millions of physical qubits to encode thousands of logical qubits, presenting a substantial hardware architecture challenge. Our modular Quantum System-on-Chip (QSoC) architecture uses a quantum microchiplet (QMC) that features compact two-dimensional arrays of diamond color centers with a resonant dielectric antenna integrated on a foundry-processed chip. Our QSoC architecture enables full connectivity for quantum memory arrays in a set of different resonant frequencies and offers the possibility of further scaling the solid-state physical qubit number via larger and denser QMC arrays and optical frequency multiplexing networking. Our QSoC architecture can efficiently generate a large scale fully connected qubit state by tuning the emitters' emission frequency. Larger qubit resources can achieve a connected qubit cluster state with less tunabiliy. Our QSoC architecture can be readily extended to other solid-state quantum memory platforms.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G06N 10/20 - Models of quantum computing, e.g. quantum circuits or universal quantum computers
• H03K 19/0948 - Logic circuits, i.e. having at least two inputs acting on one outputInverting circuits using specified components using semiconductor devices using field-effect transistors using MOSFET using CMOS
• H10H 29/14 - Integrated devices comprising at least one light-emitting semiconductor component covered by group comprising multiple light-emitting semiconductor components

Abstract

Systems that can recover metal resources, such as lithium and lithium ions, and can also sequester carbon dioxide, and related methods, are generally described.

IPC Classes  ?

• C22B 26/10 - Obtaining alkali metals
• C22B 26/12 - Obtaining lithium
• B01D 53/62 - Carbon oxides
• B01D 53/46 - Removing components of defined structure

Abstract

Various embodiments of an integrated system for capturing carbon dioxide and converting it into at least one useful product is described herein. Carbon dioxide, in some embodiments, can be captured via liquid mist, separated from a gas stream electrostatically, and converted into at least one product using any of myriad of conversion apparatuses. In some embodiments, the integrated system can remove carbon dioxide from a combustion exhaust stream.

IPC Classes  ?

• C25B 1/23 - Carbon monoxide or syngas
• C01B 32/40 - Carbon monoxide
• C07C 51/15 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis

Abstract

in vitroin vitroin vitro system for modeling Alzheimer's disease and potential applications of the models by adding more cellular compartments

IPC Classes  ?

• C12M 1/18 - Multiple fields or compartments
• C12N 5/07 - Animal cells or tissues

Abstract

Alkali metal fuel cells, and related systems and methods, are generally described. The description herein comprises materials, designs, and methods of use for an electrical power system using a metal comprising sodium metal as an energy carrier or fuel in an electrochemical reactor wherein the reactant comprises oxygen and comprises materials and designs for an electrolytic reactor producing at least a metal from a metal chloride.

IPC Classes  ?

• H01M 12/06 - Hybrid cellsManufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type with one metallic and one gaseous electrode

Abstract

Described herein are hybrid pre-miRNAs comprising user-defined targeting sequences. In some embodiments, these hybrid pre-miRNAs have greater stability when encoded by engineered self-replicating ribonucleic acids (RNAs) ("replicons") compared to non-hybrid pre-miRNAs. Also provided herein are engineered replicons comprising hybrid pre-miRNAs and, optionally, encoding additional payloads.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Disclosed herein are DSB-Prism constructs, a reporter-based (e.g., fluorescence-based) vector system for interrogating and analyzing DNA double-strand break (DSB) repair pathways, distinguishing error-free non-homologous end joining (EF-NHEJ), mutagenic NHEJ (mut-NHEJ), alternative end joining (alt-EJ), homologous recombination (HR), and single-strand annealing (SSA). In some forms the system uses a combination of fluorescent markers and genetic tools to facilitate identification of repair mechanisms utilized by cells after DSB. DSB-Prism evaluates genetic mutations, impacts of drugs, or deficiencies in DNA repair pathways. This system is applicable in numerous diseases including, but not limited to, cancer or neurodegenerative diseases or disorders.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
• C07K 19/00 - Hybrid peptides
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A magnet has a co-wound voltage sensor for high temperature superconductor (HTS) quench detection that is mechanically robust, has excellent electrical noise rejection, and can be readily integrated into existing manufacturing methods. The magnet includes one or more stackable, electrically conductive plates having several grooves into which are wound a magnet coil conductor comprising HTS tape, and in which are co-wound, proximate to the coil conductor, an insulated, two-conductor cable forming the voltage sensor. Several such cables may be co-wound along all or a portion of the coil to provide redundant or spatial measurement of normal zone formation. The grooves also may include one or more quench heaters that form part of a quench protection system (QPS) which induces a controlled magnet quench when the voltage sensor detects a normal zone having non-zero resistance within the coil conductor.

IPC Classes  ?

• H01F 6/02 - QuenchingProtection arrangements during quenching
• G01K 1/14 - SupportsFastening devicesArrangements for mounting thermometers in particular locations
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H02H 9/04 - Emergency protective circuit arrangements for limiting excess current or voltage without disconnection responsive to excess voltage
• H02H 7/00 - Emergency protective circuit arrangements specially adapted for specific types of electric machines or apparatus or for sectionalised protection of cable or line systems, and effecting automatic switching in the event of an undesired change from normal working conditions

Abstract

Provided are compositions and methods for detecting an auxin, as well as methods of preparing the compositions The compositions of the present disclosure provide a polymer of a polyamic sodium salt adsorbed on a single-walled carbon nanotube (SWNT), wherein the polymer of the polyamic sodium salt adsorbed on the SWNT forms a combination of corona phases comprising a selective binding site for an auxin. The composition may be used in a method for detecting the presence of auxin, the levels of auxin or the distribution of auxin in one or more cells in vitro or in vivo.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C01B 32/159 - Carbon nanotubes single-walled
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
• B82Y 40/00 - Manufacture or treatment of nanostructures
• A01G 7/00 - Botany in general

Abstract

Provided herein are compounds, such as compounds of Formulae (I), (I'), (XI), (XII), and (XIII), and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of agents, including polynucleotides such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, spleen diseases, lung diseases, painful conditions, psychiatric disorders, musculoskeletal diseases, metabolic disorders, inflammatory diseases, and autoimmune diseases). Also provided herein are methods of synthesis of compounds of Formulae (I'), (XI), (XII), (XIII), and (VIII).

IPC Classes  ?

• C07D 259/00 - Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
• C07D 471/10 - Spiro-condensed systems
• C07D 243/08 - Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
• C07D 255/00 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61K 31/395 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems

Abstract

The present disclosure provides methods (referred to herein as "Thick-STARmap"and "Thick-RIBOmap"), probes, compositions, kits, and systems for profiling RNA expression and/or translation in thick tissue (e.g., 20-350 micron) samples. Also provided by the present disclosure are methods for diagnosing a disease or disorder in a subject based on a profile of RNA expression and/or translation in a cell tissue, or other biological sample. Methods of screening for or testing a candidate agent capable of modulating RNA expression and/or translation are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder in a subject in need thereof. Oligonucleotide probes useful for performing the methods described herein are also provided by the present disclosure. Additionally, the present disclosure provides kits comprising any combination of the oligonucleotides described herein.

IPC Classes  ?

• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6841 - In situ hybridisation

Abstract

Systems for transferring a subject or other load from a first surface to a second surface using everting flexible inflatable structures are described. In some embodiments, a transfer system may be positioned adjacent to a second surface and one or more everting flexible inflatable structures may be moved to an extended configuration. The one or more everting flexible inflatable structures may then evert towards and under the subject or other object. The one or more everting flexible inflatable structures may then be inflated to lift the subject or other object. The flexible inflatable structure may then be moved to a retraced configuration, over a second surface to move the subject or other object onto the second surface. The subject may be lowered onto the second surface as the flexible inflatable structures are deflated and inverted.

IPC Classes  ?

• A61G 7/10 - Devices for lifting patients or disabled persons, e.g. special adaptations of hoists thereto
• A61G 7/00 - Beds specially adapted for nursingDevices for lifting patients or disabled persons
• A61G 13/12 - Rests specially adapted thereforArrangements of patient-supporting surfaces

Abstract

The present invention pertains to the fields of antibody technology, biochemistry, medicine, pharmacology, infection biology, and anti-viral therapy. More specifically, it discloses antibodies, particularly single-domain antibodies, e.g., VHH antibodies that bind an assembled HIV-1 capsid such that the capsid is prevented from entering the permeability barrier of nuclear pore complexes, also called the FG phase. Through the effects of these antibodies, HIV-1 is effectively prevented from entering the cell's nucleus and thus blocked in its life cycle.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

in vivo in situ in situ in a subject. In particular, the solid oral dosage forms, methods, and kits disclosed herein are particularly useful for drugs that require more than once daily administration (e.g, drugs that have short half-lives).

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/24 - Layered or laminated unitary dosage forms
• A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
• A61K 31/43 - Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula , e.g. penicillins, penems
• A61P 25/16 - Anti-Parkinson drugs
• A61P 31/04 - Antibacterial agents
• A61P 35/00 - Antineoplastic agents

Abstract

Described herein are circuits and systems for performing multiplication that are fast, reliable, and highly scalable. Some embodiments of the present disclosure provide an integrated circuit with a first circuit configured to multiply a first input by a first programmable scalar value using a first fixed impedance, a second circuit configured to multiply a second input by a second programmable scalar value using a second fixed impedance, and a third circuit configured to update the first programmable scalar value based on a signal propagated via the second circuit. Some embodiments of the present disclosure provide an integrated circuit with an array of multiplication circuits, each multiplication circuit having a selectable path with an impedance, and a state update circuit configured to control selection of the selectable path based on an output signal provided by a selectable path of another of the array of multiplication circuits.

IPC Classes  ?

• G06N 3/065 - Analogue means
• G06F 7/523 - Multiplying only
• G06N 3/084 - Backpropagation, e.g. using gradient descent

Abstract

Provided herein are compositions, systems, and methods for delivering cargo to a cell. The compositions, systems, and methods comprise one or more engineered Arc polypeptides, engineered delivery vesicles containing the one or more engineered Arc polypeptides, and delivering a cargo to a cell using the engineered delivery vesicles.

IPC Classes  ?

• A61K 38/00 - Medicinal preparations containing peptides

Abstract

A method for manufacturing a wearable ultrasound probe is provided. The method includes forming a plurality of slits in a layer of piezoelectric material. Each slit has a kerf size less than 40 μm and a center-to-center separation between 150 μm and 250 μm. The slits define edges of a plurality of ultrasound transducer elements that are formed in the piezoelectric material. The ultrasound transducer elements are configured to produce an acoustic radiation force impulse (ARFI) in a tissue. The method further includes adhering the layer of piezoelectric material to a matching layer and implanting a bio-adhesive layer onto the matching layer. The bio-adhesive layer is configured to adhere to skin of a subject.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• B06B 1/06 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction

Abstract

The present disclosure relates to methods of detecting and/or quantifying one or more target nucleic acid molecules in a sample, comprising: a) contacting the sample with a reaction mix comprising: i) reagents for amplifying the target nucleic acid molecules; ii) an Argonaute (Ago) enzyme, one or more guide single stranded uncleic acid molecules, and one or more reporter nucleic acid molecules; and iii) a pyrophosphatase (PPase) for regenerating Mg2+in the reaction mix; b) partitioning the mixture of the sample and the reaction mix into a plurality of compartments; c) amplifying the one or more target uncleic acid molecules in each compartment to obtain amplified target nucleic acid molecules; and d) detecting a signal in each compartment based on cleavage of the reporter nucleic acid molecules by the Ago enzyme in the presence of the amplified target nucleic acid molecules and guide single stranded nucleic acid molecules.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

Systems and methods for obtaining real-time, continuous measurements of a sample of a biological cell culture through tubing of a bioreactor by using a magnetic resonance relaxometer (MRR) device. The system pumps samples through tubing of a bioreactor (which comprises a bioreactor vessel holding the biological cell culture and the tubing through which a sample may be pumped). A portion of this tubing is routed through the MRR device and measurements are performed using magnetic resonance without the samples every leaving the bioreactor. Specifically, the return signals produced by the media (for example, water) in which the sample exists are analyzed to make inferences about the cells in the sample. The samples are then pumped back into the bioreactor vessel and returned to the culture such that none of the cells are destroyed while the measurements are obtained.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• C12N 5/07 - Animal cells or tissues

Abstract

Systems for assisting with a user's posture are disclosed. In some embodiments, the techniques described herein relate to a robotic system including a first base, one or more robotic limbs operatively connected to the first base and configured to be engaged with a body of a user of the robotic system, one or more sensors configured to sense pose information of the user proximate to the base, and one or more processors configured to determine a posture of the user based at least in part on the sensed pose information. The one or more processors may be configured to control the one or more robotic limbs to be engaged with the user's body based at least in part on the determined posture of the user.

IPC Classes  ?

• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices

Abstract

A method of detecting one or more variants in the GEN1 genetic locus in a sample from a subject suffering from a cancer, or a healthy subject not yet diagnosed with cancer, wherein if the GEN1 mutation is detected, then a therapeutic agent inhibiting MUS81, EME1, or both is administered. The tumor cells or tissue are heterozygous for the variant(s) of GEN1 or have a loss of heterozygosity. The inhibitors used to target MUS81, EME1, or both are either small molecules, antibodies, PROTACs, bi-functional molecules, recombinant gene therapy vectors, RNAi agents, antisense RNA agents, or a gene editing system.

IPC Classes  ?

• A61K 31/15 - Oximes (C=N—O—)Hydrazines (N—N)Hydrazones (N—N=)
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/12 - Genes encoding animal proteins
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 15/86 - Viral vectors
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 1/16 - YeastsCulture media therefor
• C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material

Abstract

Described herein are methods, devices, materials, and systems for extracting target materials from iron-rich feedstocks. The iron-rich feedstock may be red mud, a natural occurring mineral, and/or a waste stream. The target materials may include a main constituent of the feedstock, a rare earth element, a precious metal, and/or a platinum group element. The invention may use a combination of electrochemical reactions and physical separation methods.

IPC Classes  ?

• C22B 3/20 - Treatment or purification of solutions, e.g. obtained by leaching
• C22B 3/32 - Carboxylic acids
• C22B 3/04 - Extraction of metal compounds from ores or concentrates by wet processes by leaching

Abstract

The invention relates to compositions and methods for RNA editing. In particular, ribozymes can be utilized to enhance RNA trans-splicing.

IPC Classes  ?

• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 38/46 - Hydrolases (3)
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors
• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)

Abstract

An apparatus for imaging a cavity. The apparatus comprises an enclosure, comprising a distal end, a proximal end, and a transparent portion therebetween. The proximal end comprises at least one electrical connection, and the transparent portion is transparent to an illumination signal; and a flexible tether, operably connected to the electrical connection of the proximal end of the enclosure. The enclosure further comprises an image acquisition device, an illumination source, and an annular reflector, wherein the illumination source is configured to generate the illumination signal comprising illumination beams, the annular reflector being configured to direct at least some of the illumination beams through the transparent portion of the enclosure at the cavity, thereby generating a reflected signal comprising reflected beams, the annular reflector being further configured to direct at least some of the reflected beams at the image acquisition device, the image acquisition device being configured to capture one or more images based on the reflected signal.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
• A61B 1/06 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements

Abstract

The present disclosure provides engineered OMEGA guide molecules, trans-oligonucleotide activated OMEGA guide systems, and compositions and systems comprising engineered IscB polypeptides. Methods of modifying target polynucleotides using the compositions and systems described herein are also provided.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/22 - Ribonucleases
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

An integrated pixel cell for a display device and/or optical communication device, an LED array, and method of fabricating an integrated pixel cell for a display device and/or optical communication device. The integrated pixel cell for a display device and/or optical communication device comprises a light emitting element; a photo detecting element; CMOS circuitry for the light emitting element and the photo detecting element, wherein the CMOS circuitry, the light emitting element and the photo detecting element are provided on a same substrate of the integrated pixel cell; wherein the photo detecting element is configured to detect a part of radiated light from the light emitting element; and wherein output voltages or currents of the light emitting element and the light detecting element are detectable by a calibration circuit to calibrate the light emitting element's current or light intensity.

IPC Classes  ?

• H10F 55/155 - Radiation-sensitive semiconductor devices covered by groups , or being structurally associated with electric light sources and electrically or optically coupled thereto wherein the radiation-sensitive semiconductor devices control the electric light source, e.g. image converters, image amplifiers or image storage devices wherein the radiation-sensitive devices and the electric light source are all semiconductor devices formed in, or on, a common substrate
• H10F 55/255 - Radiation-sensitive semiconductor devices covered by groups , or being structurally associated with electric light sources and electrically or optically coupled thereto wherein the electric light source controls the radiation-sensitive semiconductor devices, e.g. optocouplers wherein the radiation-sensitive devices and the electric light source are all semiconductor devices formed in, or on, a common substrate
• H10F 39/10 - Integrated devices
• H10F 39/18 - Complementary metal-oxide-semiconductor [CMOS] image sensorsPhotodiode array image sensors

Abstract

The present disclosure provides products and methods for facilitating brain lipid transport in a subject. In some aspects the products are useful for slowing the progression of or preventing the development of Alzheimer's Disease or for treating Alzheimer's disease. The products include reconstituted lipoprotein particles (rLPs). Libraries and screening of libraries to identify additional rLPs are also disclosed.

IPC Classes  ?

• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/1275 - Lipoproteins or protein-free species thereof, e.g. chylomicronsArtificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]Precursors thereof

Abstract

A multi-axis actuated tailcone for an autonomous underwater vehicle (AUV) is provided. The AUV includes a removeable, interchangeable drive module, active and passive roll compensation, and removeable and interchangeable shrouds and fins for optimizing hydrodynamic performance. The tailcone includes a hull having an exterior surface and defining a cavity. A motor may include a shaft disposed at least partially within the hull. A drive module may be disposed in the cavity. The drive module includes one or more drivers. A plurality of fins are disposed about an exterior surface of the hull. Each fin is coupled to one of the one or more drivers. A propeller assembly is coupled to the shaft and includes a shroud.

IPC Classes  ?

• B63G 8/20 - Steering equipment
• B63G 8/00 - Underwater vessels, e.g. submarines

Abstract

A procedure for using a scanning transmission electron microscope to determine atomic position is disclosed. A diagnostic scan pattern is executed and areas of high intensity in the resulting detector output are identified. These areas may represent the position of atoms in the sample. This output is then compared to the known or measured lattice structure of the sample, and the coordinates of the identified atoms are adjusted based on the comparison. This procedure avoids exposing a target region of interest, compensates for drift, and allows for precision to be improved compared to the case where the procedure is not used, reaching values that may be better than 10 picometers.

IPC Classes  ?

• G01N 23/225 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes
• H01J 37/06 - Electron sourcesElectron guns
• H01J 37/244 - DetectorsAssociated components or circuits therefor

Abstract

The invention relates to moiré synaptic transistors and crossbar array comprising M columns and N rows of moiré synaptic transistors. The moiré synaptic transistor comprises a top gate, a bottom gate, and an asymmetric moiré heterostructure disposed between the top gate and the bottom gate; and a source and a drain spatial-apart formed on the asymmetric moiré heterostructure to define a conductance channel in the asymmetric moiré heterostructure therebetween, and wherein the top gate and the bottom gate are capacitively coupled with the conductance channel.

IPC Classes  ?

• H10D 30/67 - Thin-film transistors [TFT]
• G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means

Abstract

This disclosure relates to lipidated synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The lipidated synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.

IPC Classes  ?

• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 38/08 - Peptides having 5 to 11 amino acids

Abstract

Some aspects are related to articles for delivering therapeutic agents to a location internal to a subject. In some embodiments, the articles may include a reservoir configured to contain a therapeutic agent, a magnetic component, and a tether linking the reservoir and the magnetic component. In some embodiments, a plurality of the articles may be ingested by a subject, and the magnetic component of the articles may self- assemble into a drug delivery system at a location internal of the subject. The reservoirs of the articles may contain a large amount of a therapeutic agent (e.g., up to 50 grams of therapeutic agent) in the system, in some embodiments, and the system may be configured to release the therapeutic agent over a long time (e.g., up at 365 days). Still other aspects are related to methods of administering and/or using the articles and systems, kits containing the same, or the like.

IPC Classes  ?

• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Abstract

This disclosure relates to reversible affinity selection methods useful for the isolation and enrichment of covalent peptide inhibitors directly from large synthetic peptide libraries. Also disclosed herein are synthetic peptides for targeting HPV16 E6 and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• B01D 15/34 - Size-selective separation, e.g. size-exclusion chromatographyGel filtrationPermeation
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C40B 20/00 - Methods specially adapted for identifying library members

Abstract

The disclosure provides compositions and methods for identifying subjects having hepatocyte stress associated with a risk for developing hepatocellular carcinoma (HCC), and therapeutic methods for reducing a subject's risk of HCC, for example, by inhibiting RELB, SOX4, or HMGCS2.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Hydrogel-based heterogenous catalysts, e.g., for oxidation of organic molecules, and related articles, systems, and methods, are generally described herein.

IPC Classes  ?

• B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
• B01J 35/20 - Catalysts, in general, characterised by their form or physical properties characterised by their non-solid state
• C07C 2/84 - Preparation of hydrocarbons from hydrocarbons containing a smaller number of carbon atoms by condensation of hydrocarbons with partial elimination of hydrogen oxidative coupling catalytic

Abstract

Mycobacterium tuberculosisMycobacterium tuberculosis-derived sequences for use as immunogens and vaccine compositions.

IPC Classes  ?

• A61K 39/04 - Mycobacterium, e.g. Mycobacterium tuberculosis
• A61P 31/06 - Antibacterial agents for tuberculosis
• C12N 15/861 - Adenoviral vectors

Abstract

Aspects of the present disclosure relate, at least in part, to nucleic acids for expression of engineered genes in chloroplasts. In some embodiments, an engineered gene comprises a heterologous regulatory sequence (e.g., a promoter, a translation regulatory sequence, and/or RNA-binding proteins binding sequences). In some embodiments, nucleic acids described herein are useful for expressing peptides and/or proteins at levels that are controllable and not normally achieved when said genes are in their normal cellular environment. In some embodiments, nucleic acids described herein are useful in, for example, improving plant performance, providing resistance to plant pathogens, increasing plant growth, and production of agents which are therapeutic to a mammalian subject. In some embodiments, nucleic acids and methods described herein may be used for production of genetically engineered plants and/or seeds (e.g., of an edible crop or crops harvested for plant-based materials used in the manufacture of clothing, construction materials, etc.).

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/67 - General methods for enhancing the expression
• C12N 15/82 - Vectors or expression systems specially adapted for eukaryotic hosts for plant cells
• C12N 5/04 - Plant cells or tissues

Abstract

Disclosed herein are anti-PAPP-A synthetic peptides showing potent inhibitory activity with pronounced selectivity towards PAPP-A and over other members of metzincin family, methods of making such synthetic peptides, and methods of using such synthetic peptides for active site-directed inhibition of PAPP-A.

IPC Classes  ?

• A61K 38/55 - Protease inhibitors
• A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

Disclosed are injectable needles. Also disclosed are methods of delivering a therapy to a subject in need thereof using the injectable needles.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin