Abstract

Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ≤1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance>94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.

IPC Classes  ?

• G10K 11/168 - Plural layers of different materials, e.g. sandwiches
• B32B 7/027 - Thermal properties
• B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
• B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
• E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance

Abstract

A gene-targeting chimera including an adeno-associated virus (AAV) and a nanoparticle is disclosed. The nanoparticle may include a silica shell coating. The AAV and nanoparticle may be covalently attached using a linking chemistry. The nanoparticle may include a magnetic nanoparticle (MNP), a magnetic nanodisc (MND), or a quantum dot (QD). The gene-targeting chimeras may retain the tropism of original AAV serotype used. Additionally, The gene-targeting chimeras may also be able to be controlled using a magnetic field. The gene-targeting chimeras may enable nanoparticle delivery to specific cells and organs.

IPC Classes  ?

• C12N 15/86 - Viral vectors
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

Some aspects relate to a toroidal field (TF) coil for a tokamak. The TF coil includes a first inner leg having teeth on a side of the first inner leg. The corresponds to an interface between the TF coil and a second TF coil. The teeth extend along a direction having a component in a radial direction of the tokamak. The teeth are configured to mechanically engage with second teeth of a second inner leg of the second TF coil.

IPC Classes  ?

• G21B 1/05 - Thermonuclear fusion reactors with magnetic or electric plasma confinement
• G21B 1/11 - Thermonuclear fusion reactors Details
• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor

Abstract

Bulk nanocomposite materials comprising a solid support material and a plurality of elongated nanostructures distributed within the solid support material, and related systems and methods, are generally described. The elongated nanostructures occupy a volume fraction of at least 5 vol. %; less than or equal to 20 vol. % of the domain is occupied by voids having a volume of at least 10<7>micrometer<3>; the domain comprises a first dimension having a length of at least 1 centimeter; and the domain comprises a second dimension that is perpendicular to the first dimension, the second dimension having a length of at least 1 centimeter.

IPC Classes  ?

• B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Disclosed and claimed are mutation(s) or modification(s) of the CRISPR enzyme, for example a Cas enzyme such as a Cas9, which obtain an improvement, for instance a reduction, as to off-target effects of a CRISPR-Cas or CRISPR-enzyme or CRISPR-Cas9 system or complex containing or including such a mutated or modified Cas or CRISPR enzyme or Cas9. Methods for making and using and uses of such mutated or modified Cas or CRISPR enzyme or Cas9 and systems or complexes containing the same and products from such methods and uses are also disclosed and claimed.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

A lateral flow device, system and method can be used to detect an analyte by monitoring a change in an electronic property.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

According to one aspect of the disclosure, a system for performing quantum computations includes: a first environment for being maintained at an ambient temperature, having a classical computing processor; and a second environment for being maintained at a cryogenic temperature, having a plurality of qubits and a multiplexing circuit coupled to the plurality of qubits, each of the plurality of qubits having a gap transition frequency; wherein the classical computing processor is configured to change the states of each of the plurality of qubits by controlling the multiplexing circuit to couple particular ones of the plurality of qubits to a pulsed baseband waveform.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The present disclosure, in various embodiments, discloses hydrothermal methods, hydrothermally modified materials and dried hydrothermally modified materials. Certain dried hydrothermally modified materials can readily releases ionic species such as alkali metal ions (K+, Na+), silicate salts, and alkaline earth metal ions (Mg2+, Ca2+). Some dried hydrothermally modified materials can readily release aluminum ions and/or silicon, such as in the form of soluble silicates. Such processes and materials are useful, for example in economically preparing potassium releasing fertilizers.

IPC Classes  ?

• C05D 1/04 - Fertilisers containing potassium from minerals or volcanic rocks
• C05D 3/00 - Calcareous fertilisers
• C05D 5/00 - Fertilisers containing magnesium
• C05D 9/02 - Other inorganic fertilisers containing trace elements

Abstract

A detector for gamma irradiation comprises an oxygen ion conducting polycrystalline solid, has positively charged grain boundaries or negatively charged grain boundaries and is coupled to electrodes that measure changes in the polycrystalline solid's ionic conductance. The polycrystalline solid may include lightly doped Gd-doped CeO2, a polycrystalline ion conducting ceramic. The steady state passivation of space charge barriers at grain boundaries that may act as virtual electrodes, capturing radiation-induced electrons, in turn lowering space charge barrier heights, and thereby exclusively modulating the ionic carrier flow within the ceramic electrolytes. Such behavior may allow for an electrical response under low fields, i.e., <2 V/cm. The polycrystalline solids disclosed herein may be used in inexpensive, sensitive, low-power and miniaturizable solid-state devices, uniquely suited for operating in harsh (high temperature, high humidity, pressure, and/or corrosive) environments. The detectors disclosed herein may be suitable for simultaneous spectroscopy and dosimetry measurements.

IPC Classes  ?

• G01T 1/185 - Measuring radiation intensity with ionisation-chamber arrangements

Abstract

Disclosed herein is a hybrid electronic-ionic circuit comprising a first electrochemical ionic synapse (EIS), wherein in response to a non-zero electrical stimulus applied to the first EIS, the first EIS operates in a volatile operation mode to generate a delayed-onset self-resetting signal; and a second EIS, wherein in response to a non-zero electrical stimulus applied to the second EIS, the second EIS operates in a non-volatile operation mode and a conductance of the second EIS controls a strength of an output of the second EIS. In some embodiments, the non-zero electrical stimulus for the first EIS comprises one or more of a context signal or a variability signal. In some embodiments, the non-zero electrical stimulus for the second EIS comprises one or more of the delayed-onset self-resetting signal, a reward signal, or a context signal.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G01N 27/414 - Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS

Abstract

A control system and method locates a partially or fully occluded target object in an area of interest. The location of the occluded object may be determined using visual information from a vision sensor and RF-based location information. Determining the location of the target object in this manner may effectively allow the control system to “see through” obstructions that are occluding the object. Model-based and/or deep-learning techniques may then be employed to move a robot into range relative to the target object to perform a predetermined (e.g., grasping) operation. This operation may be performed while the object is still in the occluded state or after a decluttering operation has been performed to remove one or more obstructions that are occluding light-of-sight vision to the object.

IPC Classes  ?

• B25J 9/16 - Programme controls
• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme
• G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips

Abstract

Provided herein are antisense oligomer conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject one or more of the antisense oligomer conjugates described herein.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Abstract

Systems and methods for confining an optical signal in a non-linear optical quantum computing system are disclosed. An optical signal and a trap field are provided in the non-linear optical quantum computing system. The trap field propagates with and confines the optical signal in time and/or space. The non-linear optical quantum computing system may be structured as a ring, a single-pass waveguide or a segmented single-pass waveguide. In some cases, multiple optical signals may be input into the system and evaluated in a multiplexed fashion.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control
• G02F 1/365 - Non-linear optics in an optical waveguide structure

Abstract

Provided are engineered viral vectors, compositions comprising viral vectors, and methods of producing and using engineered viral vectors. The engineered viral vectors provided herein include capsid proteins derived from densovirus (DNV). Such DNV capsid proteins can assemble in mammalian cells and encapsulate adeno-associated virus (AAV) and/or DNV genomic DNA. The engineered viral vectors may be used as delivery vectors in target gene therapies.

IPC Classes  ?

• C12N 15/86 - Viral vectors

Abstract

The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides Cas proteins and their use in modifying target sequences.

IPC Classes  ?

• C12N 9/22 - Ribonucleases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

Systems and methods for targeted gene modification, targeted insertion, perturbation of gene transcripts, and nucleic acid editing. Novel nucleic acid targeting systems comprise components of CRISPR systems and transposable elements. CRISPR-associated transposons (CASTs) are bacterial RNA-guided Tn7-like transposons that can insert large DNA cargoes at targeted loci in bacteria. To adapt CAST for use on the human genome, Applicants screened 30 CAST I-B systems for activity on extrachromosomal DNA in human cells. Of the six active orthologs identified, Applicants engineered a I-B2 system from Tolypothrix sp. PCC7910 (TolCAST) to achieve RNA-guided DNA insertion in the genome of living human cells.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/22 - Ribonucleases
• C12N 9/64 - Proteinases derived from animal tissue, e.g. rennin
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Provided herein, in various embodiments, are methods and compositions comprising a Signal Regulatory Protein Alpha (SIRPα) therapeutic. In certain embodiments, the disclosure provides for methods and compositions for modulating SIRPα expression. In certain embodiments, the methods and compositions are useful in the treatment of a SIRPα-mediated disease or condition.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 9/51 - Nanocapsules
• A61P 35/00 - Antineoplastic agents

Abstract

According to embodiments of the present disclosure, a system includes: a microkernel having a low-level application programming interface (API) and providing memory protection domains to user-level processes; and an abstraction layer running on top of the microkernel and comprising a plurality of service extensions to the microkernel and configured to provide a high-level operating system (OS) API for use by one or more application processes running in user space, wherein different ones of the service extensions are configured to run within different ones of the memory protection domains provided by the microkernel.

IPC Classes  ?

• G06F 9/445 - Program loading or initiating
• G06F 9/30 - Arrangements for executing machine instructions, e.g. instruction decode
• G06F 9/54 - Interprogram communication

Abstract

A method and apparatus used in preparing a recrystallized metal alloy involve a cooling medium and a heating element to create a cold zone and a hot zone. An additively manufactured metal alloy preform is drawn in a draw direction from the cold zone towards the hot zone to form the recrystallized metal alloy. The cold zone and the hot zone create a surface temperature gradient on at least a portion of the preform of at least about 104 K m−1. The step of drawing causes an average grain size of at least a portion of the preform to increase in a direction parallel to the draw direction.

IPC Classes  ?

• B22F 10/64 - Treatment of workpieces or articles after build-up by thermal means
• B22F 10/28 - Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
• B22F 10/66 - Treatment of workpieces or articles after build-up by mechanical means
• B33Y 10/00 - Processes of additive manufacturing
• B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
• C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon

Abstract

Disclosed herein are silicates and/or salts and methods of production and uses thereof. For example, methods of producing an amorphous silicate and/or a salt from materials comprising silicates are disclosed. As another example, use of silicates and/or salts in the formation of cementitious materials is also disclosed.

IPC Classes  ?

• C04B 22/12 - Acids or salts thereof containing halogen in the anion, e.g. calcium chloride

Abstract

Provided herein are oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease in a subject in need thereof, comprising administrating to the subject oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates described herein.

IPC Classes  ?

• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

A novel active and passive wafer-scale fabric is disclosed that allows for the integration of very-large-scale integrated circuits (ICs) with hundreds of closely-spaced bare-die chips such as memory, GPUs, FPGAs and AI accelerators into a single wafer. The wafer-scale logic fabric allows the tiling of known good chips to make systems that perform as a single-chip monolithic device, despite comprising several smaller heterogeneous chips. This approach enables higher bandwidth and lower connectivity loss than conventional circuit board packaging, which is especially critical for AI computing and signal/image processing applications. Further, it also allows for multiple levels of high-density connections, since this architecture allows wiring between chips to be as small as the wiring within a chip. This wafer-scale platform combined with heterogeneous IP block/chiplets and μ-bump integration produces a chip-like wiring for the wafer-scale heterogeneous multi-chip system where part of chip can be removed or reconfigured.

IPC Classes  ?

• H01L 27/118 - Masterslice integrated circuits

Abstract

A reticle stage for a photolithography scanner is disclosed having a direct-drive ironless linear motor to actuate a short-stroke stage during a turnaround operation. The reticle stage may include a long stroke stage, an array of permanent magnets coupled to a beam, and at least one conductive coil mounted to the short-stroke stage without a ferromagnetic core. The beam may pass through the short-stroke stage and be coupled to one of the long-stroke stage or a balance mass, both of which may be disposed about the perimeter of the short-stroke stage. An electrical current applied to the coil may interact with the magnetic field from the permanent magnets to provide a force on the short-stroke stage.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

A reticle stage for a photolithography scanner having a pneumatic actuation system is disclosed. The pneumatic actuation system may provide a restoring force to a long-stroke stage during scan and turnaround operations. The reticle stage may have or define dual-chamber pneumatic pistons as energy storage devices to create turnaround forces for stage acceleration. As the long-stroke stage is driven by a linear motor a pressure differential is formed between the two pistons providing a net force opposing the direction of the long-stroke stage movement.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

Prompt embedding samples are drawn from a prior distribution and are passed into a pretrained model to receive a corresponding token label prediction for a batch of text data. Prompt embedding samples are accepted from a distribution of a first iteration; the accepted samples satisfy a condition of a distance function between a ground truth label and the corresponding token label prediction being less than a first tolerance. Embeddings are resampled from the accepted prompt embedding samples with probability proportional to weights and the resampled embeddings are perturbed via a perturbation kernel to obtain a new sample. The perturbed resampled embeddings are propagated through the pretrained model, and those that satisfy a condition are projected, where the second tolerance is decayed by one step per iteration. The projected resampled embeddings are concatenated with an embedding of a given input and inferencing is performed.

IPC Classes  ?

• G06F 40/284 - Lexical analysis, e.g. tokenisation or collocates

Abstract

The present invention relates to a composition comprising a polyimidazolium (PIM) compound for use in the treatment and/or prevention of mastistis in a mammal, and to methods of use.

IPC Classes  ?

• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61P 31/04 - Antibacterial agents
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors

Abstract

Systems and devices are disclosed for mobility assistance of users with instability or reduced mobility when walking. The mobility device can be a garment (e.g., pants, shorts) that includes a wearable harness embedded or otherwise associated with the garment in a manner that allows the garment to be worn without the harness being outwardly noticeable. The garment can be worn in conjunction with being connected to a walker or other mobility aid vehicle, as well as in everyday use. The harness associated with the garment provides support for the user while a majority of the harness is invisible from outside the garment. A connector can be utilized in conjunction with the same to help manage the connection between the harness and the mobility aid vehicle. The connector can include the ability to mitigate or stop a fall in response to parameters detected by sensors associated with the garment or system.

IPC Classes  ?

• A61H 3/00 - Appliances for aiding patients or disabled persons to walk about

Abstract

The introduction of low levels of cleavable comonomer additives into existing vinyl polymerization processes may facilitate the production of chemically deconstructable and recyclable variants with otherwise equivalent properties. The present disclosure describes cleavable comonomer approach as a viable strategy toward circular vinyl polymers. The present disclosure describes copolymers comprising m1 instances of the first repeating unit of Formula (i); m2 instances of the second repeating unit of Formula (ii-A) or (ii-B); and optionally one or more types of additional repeating units. The disclosure also provides compounds of the formula: or a tautomer or salt thereof. The present disclosure further describes methods of preparation, compositions, and kits. The introduction of low levels of cleavable comonomer additives into existing vinyl polymerization processes may facilitate the production of chemically deconstructable and recyclable variants with otherwise equivalent properties. The present disclosure describes cleavable comonomer approach as a viable strategy toward circular vinyl polymers. The present disclosure describes copolymers comprising m1 instances of the first repeating unit of Formula (i); m2 instances of the second repeating unit of Formula (ii-A) or (ii-B); and optionally one or more types of additional repeating units. The disclosure also provides compounds of the formula: or a tautomer or salt thereof. The present disclosure further describes methods of preparation, compositions, and kits.

IPC Classes  ?

• C08G 75/045 - Polythioethers from mercapto compounds or metallic derivatives thereof from mercapto compounds and unsaturated compounds

Abstract

Systems and methods for active and passive suppression of the transition from laminar to turbulent fluid flow in conduits for fluid transport, which include pipes, channels, and semi-confined passageways. Examples include implementations of a turbulence model that predicts a turbulence transition mode of a fluid within the conduit and systems and methods for modifying the fluid in the conduit to reduce or suppress the predicted turbulence transition mode and thereby prevent or delay transition of the fluid flow from laminar to turbulent. Examples include active and systems to introduce disturbances into the fluid flow that cancel, absorb, or reduce the predicted turbulence transition mode. Examples include conduit liners configured to absorb energy from the fluid flow at a frequency of the predicted turbulence transition mode. Examples include textures and surface geometries configured to transfer energy in the fluid flow from the predicted turbulence transition mode to a different frequency.

IPC Classes  ?

• F16L 55/02 - Energy absorbersNoise absorbers
• F15D 1/00 - Influencing the flow of fluids
• F15D 1/06 - Influencing the flow of fluids in pipes or conduits by influencing the boundary layer

Abstract

Applications of a Streptococcus Cas9 ortholog from Streptococcus macacae (Smac Cas9), possessing minimal adenine-rich PAM specificity, include an isolated Streptococcus macacae Cas9 protein or transgene expression thereof, a CRISPR-associated DNA endonuclease with PAM interacting domain amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein, and an isolated, engineered Streptococcus pyogenes Cas9 (Spy Cas9) protein with a PID as either the PID amino acid composition of the isolated Streptococcus macacae Cas9 (Smac Cas9) protein or of a CRISPR-associated DNA endonuclease with PID amino acid sequences that are at least 80% identical to that of the isolated Streptococcus macacae Cas9 protein. A method for altering expression of at least one gene product employs Streptococcus macacae Cas9 endonucleases in complex with guide RNA, for specific recognition and activity on a DNA target immediately upstream of either an “NAA” or “NA” or “NAAN” PAM sequence.

IPC Classes  ?

• C12N 15/74 - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

A photolithography system with an actuatable reticle stage is disclosed. Mechanical actuators coupled to a long-stroke reticle stage are driven to extend and mechanically contact a short-stroke stage during reticle stage turnaround. The actuators may be piezoelectric stack pushers or pneumatic bellows pushers. The pusher devices are controlled and driven to enable higher acceleration turnaround trajectories by applying forces via mechanical contact engaging during turnaround and disengaging before exposure begins during a scan.

IPC Classes  ?

• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor

Abstract

A computer-implemented method for task-guided graph augmentation and editing includes receiving an input graph in an observed financial transaction network. A data augmentation function is learned, where the data augmentation function maintains a true data distribution of the input graph. An augmented financial transaction network is generated that enhances performance of a downstream task and preserves topological and temporal properties of the input graph.

IPC Classes  ?

• G06Q 20/40 - Authorisation, e.g. identification of payer or payee, verification of customer or shop credentialsReview and approval of payers, e.g. check of credit lines or negative lists

Abstract

Disclosed are conjugates and methods of identifying ligands for substrates using said conjugates. Also disclosed herein are methods of making the conjugates.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Provided herein are compounds, such as compounds of Formulae (I) and (III), and compositions, methods, uses, and kits thereof. The compounds provided herein are poly(β-amino esters) useful for delivery of agents, such as vitamins and minerals, for the treatment and/or prevention of various diseases and conditions (e.g., micronutrient deficiency).

IPC Classes  ?

• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/07 - Retinol compounds, e.g. vitamin A
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/355 - Tocopherols, e.g. vitamin E
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/525 - Isoalloxazines, e.g. riboflavins, vitamin B2
• A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
• A61K 31/714 - Cobalamins, e.g. cyanocobalamin, vitamin B12
• A61K 33/18 - IodineCompounds thereof
• A61K 33/26 - IronCompounds thereof
• A61K 33/30 - ZincCompounds thereof
• C08G 73/06 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromoleculePolyhydrazidesPolyamide acids or similar polyimide precursors

Abstract

Removal of gas-evolving species from powders can be achieved before sintering occurs, reducing or eliminating gas evolution in a dense body that can lead to swelling, or lowering of density.

IPC Classes  ?

• B22F 3/10 - Sintering only
• B22F 1/10 - Metallic powder containing lubricating or binding agentsMetallic powder containing organic material

Abstract

A method of designing a metal alloy powder having a miscibility gap at low temperature is disclosed. The method includes identifying a first metal element and a second metal to form a metal alloy. selecting a third metal having a miscibility gap with the metal alloy. and mechanically alloying the third metal and the metal alloy to form a metal alloy powder having a nanoscale grain size. The metal alloy powder can be engineered to have a phase separation temperature at which diffusion of the third metal occurs to phase separate as a nanoscale phase. The nanoscale phase can redissolve at a transition temperature higher than the phase separation temperature.

IPC Classes  ?

• C22C 1/10 - Alloys containing non-metals
• C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon

Abstract

Disclosed are compositions comprising a lipid nanoparticle and a modified biomolecular corona. In some embodiments, the modified biomolecular corona comprises a fused cell-specific binding domain. In some embodiments, the modified biomolecular corona protein has been additionally modified such that it does not bind substantially to its natural receptor. In some embodiments, the fused cell-specific binding domain binds to a target cell.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 9/51 - Nanocapsules
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Abstract

Compositions comprising an electronically conductive polymer and a metal-organic framework (MOF), and related sensors and methods of sensing analytes, are generally described.

IPC Classes  ?

• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• H01B 1/12 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances organic substances
• H01B 1/22 - Conductive material dispersed in non-conductive organic material the conductive material comprising metals or alloys

Abstract

Disclosed herein are compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/54 - Interleukins [IL]
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 15/86 - Viral vectors

Abstract

A computer-implemented method and system for generating a predictive model include a computation engine learning a predictive model having missing or crippled data. A processor applies a formulated problem of missing or crippled data based learning to the predictive model. The computation engine reduces one or more tasks associated with the predictive model to a quadratically constrained quadratic problem (QCQP). The computation engine characterizes one or more solutions associated with the QCQP, where each of the one or more solutions is a loss function value.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

Disclosed herein are compositions comprising sterol-amino-phosphate compounds and methods of making and use thereof. Also disclosed herein are methods of making and methods of use of the compounds, compositions, and/or lipid particles disclosed herein. For example, the compounds and compositions are useful for treating a disease or disorder in humans and in animals. In some examples, the subject is a human male and the disease or disorder comprises male infertility.

IPC Classes  ?

• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61P 15/10 - Drugs for genital or sexual disordersContraceptives for impotence

Abstract

Methods involving physics-informed deep learning to help solve inverse problems of solid materials/structures related to unknown geometry include (1) identifying and characterizing unknown materials/structures and defects with accuracy and predictive capability and limited non-destructive measurements, and/or (2) designing geometrical features and parameters of solid materials and structures to achieve optimized and/or improved performance.

IPC Classes  ?

• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06N 3/08 - Learning methods
• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation

Abstract

Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.

IPC Classes  ?

• A61K 47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Several new techniques for designing nanophotonic scintillators which lead to optimal performance and novel functionalities. Important design concepts include the use of absorbing structures inspired by solar cells, angularly-selective structures, and metasurfaces. Scintillators based on conventionally overlooked materials (such as GaAs or GaN) are also disclosed, which are designed to reach efficiencies comparable or superior to state-of-the-art conventional scintillators (such as YAG:Ce and LYSO). Such scintillators provide important enhancement of scintillation yield arising from incorporation of nanophotonic patterns. Additionally, nanophotonic scintillators designed in conjunction with image post processing algorithms (such as deconvolution algorithms, tomographic reconstruction, etc.) are disclosed. These scintillators are designed in order to increase robustness, minimize the required dose/scan time or even the number of scans required in scintillation imaging. These new designs optimize the scintillator for optimal reconstruction.

IPC Classes  ?

• G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G21K 4/00 - Conversion screens for the conversion of the spatial distribution of particles or ionising radiation into visible images, e.g. fluoroscopic screens

Abstract

Structural variants of 2D polymers and composites thereof are described.

IPC Classes  ?

• C08G 69/28 - Preparatory processes
• C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs
• C08K 7/06 - Elements

Abstract

Liquid Crystal Elastomer (LCE) fibers, an apparatus for manufacturing, and a method for using the apparatus are provided. LCE fibers formed from each of a plurality of resin recipes can undergo reversible temperature driven actuation of the fiber. Each of the resin recipes forms a fiber having a different actuation temperature. The apparatus includes: an extrusion device, a drawing bobbin, a coating basin, a collector bobbin, a first plurality of curing devices, and a second plurality of curing devices, to transform a resin recipe into a LCE fiber. In operation, the extrusion device extrudes the resin through to the first plurality of curing devices for a partial cure. Once in contact with drawing bobbin the resin is coated in a fluid, and then pull through the second plurality of curing devices for a final cure by collector bobbin, where it can be collected and post-processed.

IPC Classes  ?

• C09K 19/38 - Polymers, e.g. polyamides
• B01J 27/24 - Nitrogen compounds
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
• B29C 48/05 - Filamentary, e.g. strands
• B29L 31/48 - Wearing apparel
• C08F 136/02 - Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds

Abstract

Compositions comprising fused aromatic systems and associated electrodes, electrochemical cells, and charge storage devices are generally described. Preferably, the aromatic comprising a bis-tetraamino-benzoquinone molecule and/or a tautomer, oligomer, and/or polymer thereof. Alternatively, the aromatic composition comprises an active material comprising a fused aromatic system comprising carbon atoms, hydrogen atoms, and a plurality of heteroatoms each replacing a carbon atom.

IPC Classes  ?

• H01G 11/58 - Liquid electrolytes
• C07D 241/46 - Phenazines
• H01G 11/48 - Conductive polymers
• H01M 4/60 - Selection of substances as active materials, active masses, active liquids of organic compounds

Abstract

The present disclosure provides site-selective conjugation of a pharmaceutical agent to an antibody using an affinity peptide. The antibody-pharmaceutical agent conjugates may be useful in treating, preventing, or diagnosing diseases in subjects.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C07K 1/107 - General processes for the preparation of peptides by chemical modification of precursor peptides

Abstract

Methods and systems for the electrochemical epoxidation of alkenes to generate an epoxide are described herein. Said methods and systems comprise: contacting an anode comprising an oxygen atom transfer electrocatalyst with an alkene in the presence of an electrolyte comprising water; applying a voltage to the anode and a cathode to generate the epoxide; wherein the oxygen atom transfer electrocatalyst comprises an at least partially oxidized palladium-platinum alloy characterized by the formula FX1: PdyPtzOx; wherein y is greater than 0 and less than 1; z is greater than 0 and less than 1; wherein the sum of y and z is equal to 1; and x is selected from the range of 0 to 2. The methods and systems disclosed herein comprise a significant advancement in the electrocatalytic epoxidation of alkenes in aqueous and mixed electrolytes using water as the oxygen atom transfer source.

IPC Classes  ?

• C25B 3/07 - Oxygen containing compounds
• C25B 3/23 - Oxidation
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 11/032 - Gas diffusion electrodes
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate
• C25B 11/065 - Carbon
• C25B 11/075 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound

Abstract

Compositions and methods for forming composites of polymer fibers, yarns, and textiles having enhanced elastocaloric and twistocaloric performance are provided herein. The composites can permit reversible temperature shifts within the materials, and can be used, for example, in energy conversion and thermal storage systems. These composites can be formulated by melt spinning the polymer fibers and using combinations of twisting and stretching of the polymer fibers. The fibers can include, for example, a base polymer that can be amorphous, or substantially amorphous, and desired alignment can occur, for example, by performing one or more of the various provided for techniques. In at least some embodiments, the composite materials can be further enhanced by including one or more phase change materials (PCMs), such as by cross-linking the one or more PCMs with one or more polymers and/or directly attaching the PCM(s) to the polymer(s).

IPC Classes  ?

• D01D 5/10 - Melt-spinning methods using organic materials
• D01D 5/098 - Melt-spinning methods with simultaneous stretching
• D01F 1/10 - Other agents for modifying properties
• D01F 6/30 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from copolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds comprising olefins as the major constituent
• D02G 3/44 - Yarns or threads characterised by the purpose for which they are designed

Abstract

Targeted metal ions can be harnessed from brines by feeding a mixed, aqueous, brine stream including the targeted metal ions and other dissolved ions through a water-recovery module on a first side of a first membrane. In the water-recovery module, water is passed from a monovalent-ion-rich stream on a second side of the first membrane through the first membrane into the mixed, aqueous, brine stream on the first side of the first membrane to produce a diluted, mixed, aqueous, brine stream. The diluted, mixed, aqueous, brine stream is then passed through a valency-selective ion-separation module to produce the monovalent-rich stream, and a multivalent-ion-rich stream, one of which includes a concentration of the targeted metal ions.

IPC Classes  ?

• B01D 61/58 - Multistep processes
• B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
• B01D 61/02 - Reverse osmosisHyperfiltration
• B01D 61/44 - Ion-selective electrodialysis
• C01D 15/02 - OxidesHydroxides
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• C02F 9/00 - Multistage treatment of water, waste water or sewage
• C02F 101/10 - Inorganic compounds
• C22B 3/22 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means
• C22B 3/42 - Treatment or purification of solutions, e.g. obtained by leaching by ion-exchange extraction
• C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
• C22B 26/12 - Obtaining lithium
• C22B 26/22 - Obtaining magnesium

Abstract

Systems and methods for nerve repair can include a polymer configured to form an elongated conduit to receive an in vivo nerve therein and provide a mechanical stabilization to the in vivo nerve. The polymer can be configured to degrade upon being subjected to a dissolution solution to remove the mechanical stabilization from the in vivo nerve.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for performing anastomosisButtons for anastomosis
• A61B 17/00 - Surgical instruments, devices or methods
• A61L 27/26 - Mixtures of macromolecular materials
• A61L 27/52 - Hydrogels or hydrocolloids
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/58 - Materials at least partially resorbable by the body
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers

Abstract

The present disclosure provides compositions, reagents, and methods for producing capped, circular RNA molecules, circularized RNA molecules, and in particular, circularized mRNA molecules encoding a polypeptide such as a therapeutic protein.

IPC Classes  ?

• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

Articles, systems, and methods related to the separation of at least a first species from at least a second species using nanoporous membranes are generally described.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
• B01D 61/24 - Dialysis
• B01D 69/06 - Flat membranes
• B01D 71/02 - Inorganic material
• B01D 71/56 - Polyamides, e.g. polyester-amides
• B01D 71/68 - PolysulfonesPolyethersulfones
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present disclosure provides, in some aspects, a humanized immunodeficient mouse model of human fibrosis. A humanized immunodeficient mouse model provided herein may be used, for example, for modeling human fibrosis, predicting human fibrosis, and testing putative fibrosis treatments.

IPC Classes  ?

• A01K 67/0271 - Chimeric vertebrates, e.g. comprising exogenous cells
• A01K 67/0278 - Knock-in vertebrates, e.g. humanised vertebrates

Abstract

Some aspects of the present disclosure are related to articles for measuring electrical signals internal to a subject, e.g., of the gastrointestinal tract (GI tract). The articles, in some embodiments, are ingestible and/or implantable. In some embodiments, the articles comprise a substrate comprising a plurality of electrodes, the substrate having a Young's elastic modulus of greater than or equal to 0.01 MPa and less than or equal to 200 MPa. In some such cases, the Young's elastic modulus of the substrate facilitates elastic recoil of the substrate such that at least a portion of the plurality of electrodes contact a surface of a tissue at the location internal to the subject (e.g., the GI tract) and thus facilitate measurement of electrical signals at the location internal to the subject. Other aspects are related to methods of using the articles, for example, to monitor electrical signals from the location internal to the subject.

IPC Classes  ?

• A61B 5/392 - Detecting gastrointestinal contractions
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/296 - Bioelectric electrodes therefor specially adapted for particular uses for electromyography [EMG]

Abstract

This invention provides compositions, reagents, methods, and kits for producing derivatized RNA molecules, particular mRNA molecules encoding a polypeptide and in particular a therapeutic protein, derivatized by linkage to a peptide, aptamer, synthetic DNA or RNA oligonucleotide or molecular probe, capable of targeting the derivatized RNA molecules to a particular subcellular location in a target cell.

IPC Classes  ?

• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes
• C12P 19/38 - Nucleosides

Abstract

Disclosed herein are particles, compositions, methods, and kits of particles comprising immunostimulatory agents that can be useful in the treatment or prevention of diseases, such as cancer.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 38/20 - Interleukins
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61P 35/00 - Antineoplastic agents

Abstract

A system and method for interactive visualization of knowledge provided by large language models (LLMs) is disclosed. The system advantageously organizes LLM responses into an interactive knowledge graph visualization. Additionally, the system enables the user to interactively expand a knowledge graph by further prompting the LLM to provide additional responses that include additional knowledge. When applied to the task of design ideation, the interactive knowledge graph visualization helps to mitigate design fixation and enhances the overall efficiency, quality, quantity, and depth of concepts in the ideation process.

IPC Classes  ?

• G06N 5/022 - Knowledge engineeringKnowledge acquisition

Abstract

Described herein are engineered antigen presenting cells that can be capable of modulating a target T-cell in a T-cell antigen specific manner. In some embodiments, the engineered APCs can include a modified antigen presentation pathway. Also described herein are methods of making and using the engineered antigen presenting cells.

IPC Classes  ?

• C12N 5/0781 - B cellsProgenitors thereof
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/13 - B-cells
• A61K 40/22 - Immunosuppressive or immunotolerising
• A61K 40/24 - Antigen-presenting cells [APC]
• A61K 40/32 - T-cell receptors [TCR]
• A61K 40/41 - Vertebrate antigens
• A61K 40/42 - Cancer antigens
• C07K 14/74 - Major histocompatibility complex [MHC]
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes

Abstract

A device configured to be implanted in a subject includes a sensing module, a therapeutic module, and a battery. The sensing module includes at least two of an accelerometer, an electrocardiogram (ECG) sensor, a photoplethysmogram (PPG) sensor, and a temperature sensor. The therapeutic module includes a drug reservoir and a reciprocating pump. The battery powers the sensing module and the therapeutic module. The sensing module is configured to detect a biological event in the subject and, upon detection of the biological event, send a signal to the therapeutic module. The therapeutic module is configured to receive the signal from the sensing module and, upon receiving the signal, administer a drug to the subject from the drug reservoir via the pump.

IPC Classes  ?

• A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
• A61M 5/142 - Pressure infusion, e.g. using pumps

Abstract

Disclosed herein are systems and techniques for seamless and scalable piezoresistive matrix-based intelligent textile development using digital flat-bed and circular knitting machines. Disclosed embodiments allow for combining and customizing functional conductive and polyester and spandex yarns, thus allowing for designing the aesthetics and architecting and engineering both the electrical and mechanical properties of the pressure sensing textile. In addition, by incorporating a melting fiber, disclosed embodiments allow for shaping and personalizing a three-dimensional piezoresistive fabric structure that can conform to the human body through thermoforming principles.

IPC Classes  ?

• D04B 15/66 - Devices for determining or controlling patterns
• D04B 1/16 - Other fabrics or articles characterised primarily by the use of particular thread materials synthetic threads
• D04B 1/24 - Weft knitting processes for the production of fabrics or articles not dependent on the use of particular machinesFabrics or articles defined by such processes specially adapted for knitting goods of particular configuration wearing apparel
• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
• G06F 3/045 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means using resistive elements, e.g. a single continuous surface or two parallel surfaces put in contact
• G06F 30/10 - Geometric CAD

Abstract

Disclosed embodiments may include systems and methods of a permanent magnet (PM) hybrid core inductor and fabrication methods thereof. The permanent magnet hybrid core may include a first set of members comprising a soft magnetic material, the first set of members forming a first gap between two end faces of the first set of members, and a second set of members comprising a permanent magnetic material and located adjacent to the first set of members, wherein the second set of members provides at least a partially parallel path to the first set of members for flow of magnetic flux lines. Some embodiments may include an inductor comprising the permanent magnet hybrid core, or a power conversion circuit including a switched capacitor circuit and a switching regulator, the switching regulator including an inductance, the inductance comprising an electrical conductor wound around a permanent magnet hybrid core.

IPC Classes  ?

• H01F 27/255 - Magnetic cores made from particles

Abstract

This disclosure relates to new multi-modal sensing array architectures that can sense normal and shear forces. Examples include resistive sensing arrays that are used to measure changes in the environment and manufacturing processes to produce multi-modal sensing arrays in a highly-automated and inexpensive fashion. Specifically, a manufacturing process includes a cutting operation and sewing/embroidery technique that creates a fully automated process to produce a resistive sensing array. The new manufacturing process enables the reduction of processing time and materials to produce a functioning sensor without limiting the designs space of achievable sensor geometries. Also presented are sensor reading methodologies for high-speed reading that are capable of sensing vibrations and a wide range of forces. Examples include the use of the new sensor arrays in wearable devices.

IPC Classes  ?

• G01L 1/20 - Measuring force or stress, in general by measuring variations in ohmic resistance of solid materials or of electrically-conductive fluidsMeasuring force or stress, in general by making use of electrokinetic cells, i.e. liquid-containing cells wherein an electrical potential is produced or varied upon the application of stress
• G06F 3/045 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means using resistive elements, e.g. a single continuous surface or two parallel surfaces put in contact

Abstract

A time varying laser which can operate by taking advantage of transitions between time varying quasi-energy levels which are present in the driven system is disclosed. This can allow for laser operation at frequencies which are new, compared to the operation of the laser in absence of time-modulation. It can also allow for a novel mode of operation in which the system provides gain at multiple frequencies simultaneously, in a coherent fashion which is fundamentally different from multi-mode behavior in conventional lasers. Additionally, in systems with sufficiently strong modulation, these principles can lead to lasers which produce gain even in the thermodynamic ground state of the system, leading to a new form of lasing without inversion (LWI). In addition, these techniques have the potential to be used to create lasers at high frequencies (UV-Xray) which have been difficult to achieve via conventional laser mechanisms.

IPC Classes  ?

• H01S 3/09 - Processes or apparatus for excitation, e.g. pumping

Abstract

A terahertz imaging system is disclosed. The terahertz imaging system includes a terahertz antenna array, made up of a plurality of antenna elements. Each antenna element includes a patch antenna, a one bit phase shifter, and a plurality of storage elements. The storage elements are used to store a plurality of phase states that are supplied to the one bit phase shifter. The one bit phase shifter is configured to either shift the phase of the incoming signal by 90 or 270, depending on the value of the phase state. The one bit phase shifter is also bidirectional, allowing it to phase shift transmitted signals and reflected signals. A plurality of these antenna elements are disposed in a semiconductor device, where the top metal layer is exposed. This top metal layer is used to create the patch antennas.

IPC Classes  ?

• H01Q 15/22 - Reflecting surfacesEquivalent structures functioning also as polarisation filter
• H01Q 15/24 - Polarising devicesPolarisation filters
• H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart

Abstract

The exponential growth in deep learning models is challenging existing computing hardware. Optical neural networks (ONNs) accelerate machine learning tasks with potentially ultrahigh bandwidth and nearly no loss in data movement. Scaling up ONNs involves improving scalability, energy efficiency, compute density, and inline nonlinearity. However, realizing all these criteria remains an unsolved challenge. Here, we demonstrate a three-dimensional spatial time-multiplexed ONN architecture based on dense arrays of microscale vertical cavity surface emitting lasers (VCSELs). The VCSELs, coherently injection-locked to a leader laser, operate at gigahertz data rates with a 7T-phase-shift voltage on the 10-millivolt level. Optical nonlinearity is incorporated into the ONN with no added energy cost using coherent detection of optical interference between VCSELs.

IPC Classes  ?

• G06N 3/067 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using optical means

Abstract

A cantilever may include a first dielectric layer that has a first intrinsic stress and a second dielectric layer overlying the first dielectric layer that has a second intrinsic stress that is different than the first intrinsic stress. The difference between the first and second intrinsic stresses may cause the cantilever to curve. A second dielectric layer can comprise a plurality of crossbars oriented at an angle relative to a length of the cantilever to reduce curvature in a width direction of the cantilever. The second dielectric layer can be patterned with a waveguide. The cantilever may be piezoelectrically actuated.

IPC Classes  ?

• H10N 30/20 - Piezoelectric or electrostrictive devices with electrical input and mechanical output, e.g. functioning as actuators or vibrators
• G02F 1/295 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection in an optical waveguide structure
• H01L 25/16 - Assemblies consisting of a plurality of individual semiconductor or other solid-state devices the devices being of types provided for in two or more different subclasses of , , , , or , e.g. forming hybrid circuits

Abstract

Methods for growing an epitaxial layer are described herein. In some embodiments, an epitaxial layer is grown over a structure comprising a crystalline substrate and a mask. The mask can be patterned with a plurality of elongated domains that help may facilitate the growth of the epitaxial layer with a reduced number of defects on the crystalline substrate. The mask may also facilitate the separation of the epitaxial layer from the crystalline substrate to form a separated epitaxial layer that is freestanding. In some embodiments, the method for growing an epitaxial layer may allow for heteroepitaxy of compound semiconductors on elemental substrates with a reduced number of defects despite polarity and/or lattice mismatches.

IPC Classes  ?

• H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
• C30B 25/04 - Pattern deposit, e.g. by using masks
• C30B 29/06 - Silicon
• C30B 29/08 - Germanium
• C30B 33/00 - After-treatment of single crystals or homogeneous polycrystalline material with defined structure

Abstract

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues of organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provide dare methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
• C12N 15/86 - Viral vectors

Abstract

Described in various embodiments herein are tiled amplification nucleic acid detection systems and uses thereof. In some embodiments, the nucleic acids amplified and detected are cell free DNA (cfDNA).

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/6888 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms

Abstract

An apparatus and method produce, from a Gaussian laser pulse, a sequence of laser rings having a spatiotemporal configuration such that impingement of the laser rings on a surface of a nuclear material in a target assembly produces constructively interfering shock waves that converge on a focal region of the nuclear material, thereby producing sufficient pressures and temperatures to form tritium in the focal region. The temporal and/or spatial intervals between the concentric pulsed laser rings are adjusted to substantially match propagation times of impingement from one ring to the next in a shock propagation layer of the target assembly. A second laser or neutron tube may be used to create a cavitation bubble at the focus. In addition to the shock waves generated in the plane of the surface, through-plane shock waves can be generated to increase the overall shock pressure.

IPC Classes  ?

• G21G 1/12 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes outside of nuclear reactors or particle accelerators by electromagnetic irradiation, e.g. with gamma or X-rays
• G21B 1/03 - Thermonuclear fusion reactors with inertial plasma confinement
• G21B 1/13 - First wallBlanketDivertor
• G21B 1/19 - Targets for producing thermonuclear fusion reactions
• G21B 1/23 - Optical systems, e.g. for irradiating targets, for heating plasma or for plasma diagnostics
• G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes

Abstract

The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides mutated Cas13 proteins and their use in modifying target sequences as well as mutated Cas13 nucleic acid sequences and vectors encoding mutated Cas13 proteins and vector systems or CRISPR-Cas13 systems.

IPC Classes  ?

• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• A61K 38/00 - Medicinal preparations containing peptides
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/6823 - Release of bound markers
• C12Q 1/6851 - Quantitative amplification

Abstract

RNA editing tools for use in systems designed to measure RNA in vivo and manipulate specific cell types are disclosed herein. An RNA sensor system comprising a) a single-stranded RNA (ssRNA) sensor comprising a stop codon and a payload; optionally wherein the ssRNA sensor further comprises a normalizing gene; and b) an adenosine deaminase acting on RNA (ADAR) deaminase; wherein the sensor is capable of binding to a ssRNA target to form a double-stranded RNA (dsRNA) duplex that becomes a substrate for the ADAR deaminase; wherein the substrate comprises a mispairing within the stop codon; and wherein the mispairing is editable by the ADAR deaminase, which editing can effectively remove the stop codon so as to enable translation and expression of the payload. A method of quantifying ribonucleic acid (RNA) levels using the RNA sensor system is also disclosed.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 9/50 - Proteinases
• C12N 9/78 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6897 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Abstract

Some aspects of the present disclosure are related to modified electrodes, for example, for use in fuel cells. In some cases, the electrode may comprise a mixed-ionic-electronic-conducting (MIEC) oxide and a basic oxide. In some cases, the basic oxide may alter the electron density of the MIEC oxide and improve its catalytic performance, for example, like the oxygen reduction reaction. For instance, the catalytic performance of a MIEC oxide comprising a perovskite towards the oxygen reduction reaction (ORR) may be improved by using a basic oxide comprising CaO and/or Li2O. Some aspects disclosed herein are directed to methods of preventing or treating chromia or silica poisoning of a MIEC oxide, wherein the method comprises treating the MIEC electrode with a basic oxide infiltrant.

IPC Classes  ?

• H01M 4/90 - Selection of catalytic material
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells

Abstract

Disclosed herein are metabolically engineered cells capable of producing carotenoids from acid whey.

IPC Classes  ?

• C12P 23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/10 - Transferases (2.)
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/90 - Isomerases (5.)
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12P 5/00 - Preparation of hydrocarbons

Abstract

Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.

IPC Classes  ?

• C04B 2/08 - Devices therefor
• B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
• C04B 7/06 - Portland cement using alkaline raw materials

Abstract

Parameters of a first transformer are accessed, and size dimensions of a second transformer that is to be trained and is larger than the first transformer are received. The parameters of the first transformer are linearly transformed using a combination of a width-growth operator and a depth-growth operator, wherein the linear transformation produces a set of new parameters, the set corresponding to the size dimensions of the second transformer. The second transformer is initialized with the set of new parameters.

IPC Classes  ?

• G06N 3/08 - Learning methods
• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks

Abstract

Compositions including solid forms of polypeptides such as crystalline antibodies, and related methods, are generally described. The compositions may include carriers such as hydrogels that at least partially encapsulate the solid form of the polypeptides (e.g., crystals, amorphous solids). Encapsulation with certain of the materials described may result in compositions containing relatively high loadings of polypeptides while in some instances retaining structural and functional properties of the polypeptides useful for certain types of administration to subjects (e.g., for prophylactic or therapeutic applications). In some instances, compositions having relatively low dynamic viscosities while having relatively high polypeptide loadings are provided.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 9/06 - OintmentsBases therefor

Abstract

Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In son embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• C12N 15/86 - Viral vectors

Abstract

Products, such as devices, prostheses, and materials, whose surfaces have been modified in order to impart beneficial properties to these products are disclosed. The surface-modified products have improved biocompatibility compared to a corresponding product that lacks the modification. Following implantation in a subject, the surface-modified products induce a lower foreign-body response, compared to a corresponding unmodified product.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 35/12 - Materials from mammalsCompositions comprising non-specified tissues or cellsCompositions comprising non-embryonic stem cellsGenetically modified cells
• A61K 35/36 - SkinHairNailsSebaceous glandsCerumenEpidermisEpithelial cellsKeratinocytesLangerhans cellsEctodermal cells
• A61K 35/39 - PancreasIslets of Langerhans
• A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
• A61L 27/04 - Metals or alloys
• A61L 27/10 - Ceramics or glasses
• A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• A61L 27/20 - Polysaccharides
• A61L 27/34 - Macromolecular materials
• A61L 27/54 - Biologically active materials, e.g. therapeutic substances
• A61L 27/56 - Porous or cellular materials
• A61L 29/14 - Materials characterised by their function or physical properties
• C08J 7/12 - Chemical modification

Abstract

The disclosure features compositions, systems, and methods for preparation and use of efficient RNA nuclear export of ribozyme-assisted circular RNA molecules (racRNAs). In embodiments, the methods involve characterizing a cell or tissue using racRNAs.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
• C12N 15/86 - Viral vectors
• C12Q 1/6841 - In situ hybridisation
• C12Q 1/6881 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• G16B 25/10 - Gene or protein expression profilingExpression-ratio estimation or normalisation
• G16B 50/30 - Data warehousingComputing architectures

Abstract

This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/22 - Ribonucleases
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/90 - Stable introduction of foreign DNA into chromosome

Abstract

In some aspects, the present disclosure pertains to methods for the electrochemical production of NH3 from nitrogen gas and a hydrogen-containing molecule in an electrochemical cell that comprises a cathode, an anode and a lithium-ion-containing electrolyte disposed between the cathode and the anode. The electrochemical cell is operated under conditions such that lithium ions in the electrolyte are converted to lithium metal at the cathode, the lithium metal reacting with nitrogen gas to form Li3N, and the Li3N reacting with protons in a proton donor to form NH3, lithium ions and a deprotonated proton donor. Moreover, the proton donor has a Kamlet-Taft alpha parameter (α) greater than 0.7 and a Kamlet-Taft beta parameter (β) greater than 0.5. Other aspects of the present disclosure pertain to systems for electrochemical production of NH3.

IPC Classes  ?

• C25B 1/27 - Ammonia
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• C25B 11/046 - Alloys

Abstract

The present disclosure provides cyclic silyl ethers of the formula: The present disclosure provides cyclic silyl ethers of the formula: The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.

IPC Classes  ?

• C07F 7/08 - Compounds having one or more C—Si linkages
• A61K 31/787 - Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C08G 61/06 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08L 83/04 - Polysiloxanes

Abstract

The present invention relates to recombinant targeting peptides, compositions comprising said targeting peptides and methods of targeted delivery of therapeutics suitable for the control, improvement and/or treatment of acne. More particularly, the present invention provides engineered targeting peptides that bind specifically to the cell wall of Cutibacterium acnes, capable of providing a homing mechanism for transporting nanoparticles comprising therapeutics to C. acnes. Accordingly, the present invention also provides methods and compositions comprising the recombinant targeting peptides for localized delivery of therapeutics to C. acnes.

IPC Classes  ?

• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 31/327 - Peroxy compounds, e.g. hydroperoxides, peroxides, peroxy acids
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 17/10 - Anti-acne agents
• C12N 9/36 - Hydrolases (3.) acting on glycosyl compounds (3.2) acting on beta-1, 4 bonds between N-acetylmuramic acid and 2-acetylamino 2-deoxy-D-glucose, e.g. lysozyme

Abstract

Described herein are medical devices and medical implements with high lubricity to flesh (or biological fluid) and/or inhibited nucleation on its surface. The device has a surface comprising an impregnating liquid and a plurality of micro-scale and/or nano-scale solid features spaced sufficiently close to stably contain the impregnating liquid therebetween. The impregnating liquid fills spaces between said solid features, the surface stably contains the impregnating liquid between the solid features, and the impregnating liquid is substantially held in place between the plurality of solid features regardless of orientation of the surface.

IPC Classes  ?

• A61L 31/14 - Materials characterised by their function or physical properties
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/02 - SuppositoriesBougiesBases for suppositories or bougies
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 9/70 - Web, sheet or filament bases
• A61L 15/34 - Oils, fats, waxes, or natural resins
• A61L 15/42 - Use of materials characterised by their function or physical properties
• A61L 27/28 - Materials for coating prostheses
• A61L 27/34 - Macromolecular materials
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 28/00 - Materials for colostomy devices
• A61L 29/08 - Materials for coatings
• A61L 29/14 - Materials characterised by their function or physical properties
• A61L 31/08 - Materials for coatings
• A61L 31/10 - Macromolecular materials

Abstract

The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

IPC Classes  ?

• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

Component errors prevent linear photonic circuits from being scaled to large sizes. These errors can be compensated by programming the components in an order corresponding to nulling operations on a target matrix X through Givens rotations X→T†X, X→XT†. Nulling is implemented on hardware through measurements with feedback, in a way that builds up the target matrix even in the presence of hardware errors. This programming works with unknown errors and without internal sources or detectors in the circuit. Modifying the photonic circuit architecture can reduce the effect of errors still further, in some cases even rendering the hardware asymptotically perfect in the large-size limit. These modifications include adding a third directional coupler or crossing after each Mach-Zehnder interferometer in the circuit and a photonic implementation of the generalized FFT fractal. The configured photonic circuit can be used for machine learning, quantum photonics, prototyping, optical switching/multicast networks, microwave photonics, or signal processing.

IPC Classes  ?

• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G01B 9/02001 - Interferometers characterised by controlling or generating intrinsic radiation properties

Abstract

An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

IPC Classes  ?

• C09J 7/32 - Water-activated, e.g. for gummed paper
• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• C08K 5/00 - Use of organic ingredients
• C09J 7/20 - Adhesives in the form of films or foils characterised by their carriers
• C09J 105/00 - Adhesives based on polysaccharides or on their derivatives, not provided for in groups or
• C09J 109/04 - Latex
• C09J 125/08 - Copolymers of styrene
• C09J 129/04 - Polyvinyl alcoholPartially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• C09J 133/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
• C09J 133/10 - Homopolymers or copolymers of methacrylic acid esters
• C09J 133/26 - Homopolymers or copolymers of acrylamide or methacrylamide
• C09J 151/00 - Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsAdhesives based on derivatives of such polymers
• C09J 175/00 - Adhesives based on polyureas or polyurethanesAdhesives based on derivatives of such polymers
• C09J 181/08 - Polysulfonates

Abstract

Described herein are nanoparticles comprising an LNP core with electrostatically adsorbed anionic polymers layered on the LNP surface. These nanoparticles comprise varying nucleic acid cargos and may further comprise targeting moieties covalently attached to the anionic polymers. Also provided are methods of administering cargo to a subject, methods of treatment, methods of editing a gene, and methods of reducing non-targeted cell uptake of nanoparticles.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

Abstract

The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorder.

IPC Classes  ?

• A61K 35/30 - NervesBrainEyesCorneal cellsCerebrospinal fluidNeuronal stem cellsNeuronal precursor cellsGlial cellsOligodendrocytesSchwann cellsAstrogliaAstrocytesChoroid plexusSpinal cord tissue
• A61K 31/14 - Quaternary ammonium compounds, e.g. edrophonium, choline
• A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

Described is an optimal-control system and method provide an efficient routine for differentiating the most general Unitary, Liouville, or Monte-Carlo Schrödinger equation associated with the control problem of interest.

IPC Classes  ?

• G06N 10/60 - Quantum algorithms, e.g. based on quantum optimisation, or quantum Fourier or Hadamard transforms
• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

Methods and compositions for treating a cutaneous wound to treat or limit development of a pathogenic bacterial infection are provided, involving administering to a subject having a cutaneous wound an amount effective of Corynebacteria spp., or a disclosed, composition, to treat or limit development of pathogenic bacterial infection of the wound.

IPC Classes  ?

• A61K 35/741 - Probiotics
• A61K 31/201 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having one or two double bonds, e.g. oleic or linoleic acid
• A61K 31/7004 - Monosaccharides having only carbon, hydrogen and oxygen atoms
• A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61P 31/04 - Antibacterial agents

Abstract

The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA with comparable levels of sensitivity and can differentiate targets from non-targets based on single base pair differences. Moreover, the embodiments disclosed herein can be prepared in freeze-dried format for convenient distribution and point-of-care (POC) applications. Such embodiments are useful in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, sensitive genotyping, and detection of disease-associated cell free DNA.

IPC Classes  ?

• C12Q 1/6869 - Methods for sequencing
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12P 19/34 - Polynucleotides, e.g. nucleic acids, oligoribonucleotides
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6809 - Methods for determination or identification of nucleic acids involving differential detection
• C12Q 1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

Described is a high-temperature superconductor (HTS) cable, comprising a plurality of HTS tapes, wherein all or part of a cross-section of at least one of the HTS tapes are removed to reduce the current carrying capacity of the HTS tape. Also described is a method for shaping the current density of a high-temperature superconductor (HTS) cable, wherein the HTS current density is carried by HTS tapes, and wherein the method comprises selective mechanical removal of all or part of the cross section of one or more of HTS tapes.

IPC Classes  ?

• H01B 12/02 - Superconductive or hyperconductive conductors, cables or transmission lines characterised by their form
• H01B 13/00 - Apparatus or processes specially adapted for manufacturing conductors or cables

Abstract

Methods for detecting the presence of a pathogen infection are described. In particular, this document provides a method of detecting target nucleic acids, such as pathogen-specific RNA, in a biological sample obtained from a subject, where the method comprises using one or more toehold switch sensors and an isothermal amplification step to detect the target nucleic acid. Methods specific for detecting and identify the presence of a virus such as Zika virus are also provided.

IPC Classes  ?

• C12Q 1/6827 - Hybridisation assays for detection of mutation or polymorphism
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage

Abstract

Femto-satellites are very small satellites that can be deployed in constellations from a larger mothership satellite for distributed measurement. They are too small to accommodate the GNSS receivers that many satellites use for navigation, but they can be located with an electromagnetic beam from the mothership satellite. The mothership satellite scans this beam across a constellation of femto-satellites. When the beam scans across a particular femto-satellite, the femto-satellite transmits an acknowledgement to the mothership satellite, e.g., by retroreflecting the beam or via a separate radio link. The beam can be modulated with commands for the femto-satellite, such as to make a measurement or transmit previously acquired data, as well with commands for determining the femto-satellite's location, such as a time stamp or beam pointing information. The femto-satellite can determine its location from the information modulated onto the beam or transmit the time stamp to the mothership satellite for localization.

IPC Classes  ?

• B64G 3/00 - Observing or tracking cosmonautic vehicles
• B64G 1/10 - Artificial satellitesSystems of such satellitesInterplanetary vehicles
• B64G 1/44 - Arrangements or adaptations of power supply systems using radiation, e.g. deployable solar arrays
• G01S 1/70 - Beacons or beacon systems transmitting signals having a characteristic or characteristics capable of being detected by non-directional receivers and defining directions, positions, or position lines fixed relatively to the beacon transmittersReceivers co-operating therewith using electromagnetic waves other than radio waves
• G01S 5/16 - Position-fixing by co-ordinating two or more direction or position-line determinationsPosition-fixing by co-ordinating two or more distance determinations using electromagnetic waves other than radio waves
• G01S 17/74 - Systems using reradiation of electromagnetic waves other than radio waves, e.g. IFF, i.e. identification of friend or foe

Abstract

This disclosure relates to synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

Abstract

Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors