The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.
A01K 67/0275 - Genetically modified vertebrates, e.g. transgenic
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 14/72 - ReceptorsCell surface antigensCell surface determinants for hormones
C12N 9/06 - Oxidoreductases (1.), e.g. luciferase acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/90 - Stable introduction of foreign DNA into chromosome
2.
DELIVERY, USE AND THERAPEUTIC APPLICATIONS OF THE CRISPR-CAS SYSTEMS AND COMPOSITIONS FOR TARGETING DISORDERS AND DISEASES USING PARTICLE DELIVERY COMPONENTS
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery particle formulations and/or systems comprising one or more components of a CRISPR-Cas system, which are means for targeting sites for delivery. The delivery particle formulations of the invention are preferably nanoparticle delivery formulations and/or systems. Also provided are vectors and vector systems some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
Wacker oxidation can be used as a signal transduction mechanism for the selective and sensitive detection of ethylene in air via chemiresistive sensing. Using this system, the senescence of lisianthus flowers and carnations can be monitored.
G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
This steel compositions for use in additive manufacturing are disclosed. In some embodiments, a metal alloy includes a majority iron in addition to carbon, molybdenum, vanadium, and tungsten. Overall, there may be a ratio of a combined atomic percentage of molybdenum, vanadium, and tungsten relative to carbon that is between or equal to 2:1 and 5:1. Other components such as grain refiners and/or oxidation resistant materials may also be included in such an alloy.
The present disclosure provides polymers comprising n12 instances of a moiety of Formula (I): or a salt thereof. The present disclosure also provides methods of preparing the polymers and methods of degrading the polymers. Contacting the polymers with a fluoride nucleophile (e.g., tetrabuty lammonium fluoride) or acid (e.g. octanoic acid) may degrade the polymers by cleaving the O—Si bonds. The polymers may be useful as degradable polymers, adhesives, coatings, elastomers, sealants, flexible foams, or structural materials.
A method includes receiving data characterizing a number of documents, including data associating each document with a number of utility scores. Each utility score characterizes a different type of utility of the document to a consumer of the document. A subset of the documents is selected for presentation to a user, the selecting being based at least in part on the respective utility scores associated with each of the documents and the subset of documents is provided for presentation to the user.
A doped (ultra-)wide bandgap ((U)WBG) semiconductor can demonstrate photoconductivity when illuminated with sub-bandgap light. Forming a rectifying semiconductor-metal junction on a suitably doped (U)WBG semiconductor enables a photoconductive semiconductor switch (PCSS) actuated by visible light with strong photoresponsivity and fast operation. A PCSS realized in Ge-doped AlN achieves an on/off ratio over one million, and a photoresponsivity of 2.8 A/W under sub-bandgap illumination at center wavelength 455 nm and power density as low as 1 mW/cm2. The PCSS can be turned off in under a second with a bias pulse that accelerates electron-hole recombination in the rectifying junction, quenching persistent photoconductivity. It also enables a semiconductor photodetector can measure very bright light without saturation or damage, and at elevated temperature. Such a photodetector realized in Ge-doped AlN demonstrates linear, non-saturating photoresponse for visible illumination power density up to ≥10.8 W/cm2 and operating temperature up to ≥200° C.
H10F 55/25 - Radiation-sensitive semiconductor devices covered by groups , or being structurally associated with electric light sources and electrically or optically coupled thereto wherein the electric light source controls the radiation-sensitive semiconductor devices, e.g. optocouplers wherein the radiation-sensitive devices and the electric light source are all semiconductor devices
H03K 17/78 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of opto-electronic devices, i.e. light-emitting and photoelectric devices electrically- or optically-coupled
H03K 17/94 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the way in which the control signals are generated
H10F 30/221 - Individual radiation-sensitive semiconductor devices in which radiation controls the flow of current through the devices, e.g. photodetectors the devices having potential barriers, e.g. phototransistors the devices being sensitive to infrared, visible or ultraviolet radiation the devices having only one potential barrier, e.g. photodiodes the potential barrier being a PN homojunction
H10F 55/20 - Radiation-sensitive semiconductor devices covered by groups , or being structurally associated with electric light sources and electrically or optically coupled thereto wherein the electric light source controls the radiation-sensitive semiconductor devices, e.g. optocouplers
H10F 77/00 - Constructional details of devices covered by this subclass
H10F 77/124 - Active materials comprising only Group III-V materials, e.g. GaAs
Described herein is evolution strategy that leverages highly efficient tRNA charging chemistry for cell-free ribosomal translation of proteins, including fluorogenic sensors. The fluorogenic sensors provided are capable of detecting targets, including antigens such as SARS-CoV-2 variants (e.g., Omicron variants).
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
C07H 1/00 - Processes for the preparation of sugar derivatives
C07H 23/00 - Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
A reactor system and method for oxidizing methane can include an environmentally friendly catalyst material that converts methane to an oxidized product at low temperatures and concentrations, for example, to reduce or eliminate methane in coal mine air, dairy barns, oil and gas fields, and direct air conversion applications.
Disclosed are methods for making lased poly(acrylonitrile) (PAN). Also disclosed herein are components (e.g., electrodes and batteries) comprising lased PAN.
A sample holder for advanced in-situ microscopy is described. The sample holder includes integrated devices to apply external fields and other stimuli to samples being inspected. The integrated devices can emulate operating environments for the samples. The sample holder and advanced microscopy can be used to study quantum characteristics and properties of samples.
Systems, methods, and other embodiments described herein relate to controlling a model using data fusion and a multi-modal conditional embedding for generating an object design. In one embodiment, a method includes constructing a completed parameter and an assembled component using completion models from an assembly graph, an incomplete parameter, and a component image about an object design. The method also includes generating input embeddings using encoding models associated with the completed parameter, the assembled component, and a text description. The method also includes computing a multi-modal conditional embedding using multi-modal fusion from the input embeddings. The method also includes controlling a foundational model using the multi-modal conditional embedding with a controlnet and outputting a generated object.
System and methods are provided for body motion tracking. The system includes one or more ultrasound systems configured to be worn by a subject and to acquire ultrasound data during motion of a first location on the subject. The system also includes one or more inertia measurement unit (IMU) systems configured to be worn on a second location on the subject and to measure inertia data associated with motion of the second location and a control system configured to integrate the ultrasound data and the inertia data to generate position data, the position data characterizing a motion of one of the first or second location on the subject.
G01C 21/16 - NavigationNavigational instruments not provided for in groups by using measurement of speed or acceleration executed aboard the object being navigatedDead reckoning by integrating acceleration or speed, i.e. inertial navigation
A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.
The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
C08F 4/74 - MetalsMetal hydridesMetallo-organic compoundsUse thereof as catalyst precursors selected from metals not provided for in group selected from refractory metals
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
15.
NOVEL COMBINATION OF RIFAXIMIN AND CLARITHROMYCIN FOR TREATING MULTIDRUG-RESISTANT MYCOBACTERIUM ABSCESSUS
The present invention relates to a novel synergistic combination of rifaximin and clarithromycin. The invention also relates to a kit comprising such combination, and such combination for use as pharmaceuticals, for instance in the treatment of bacterial diseases, including diseases caused by pathogenic mycobacteria such as clarithromycin-resistant and clarithromycin non-resistant non-tuberculosis mycobacteria.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Singapore-MIT Alliance For Research and Technology (Singapore)
Inventor
Han, Jongyoon
Chew, Sing Yian
Nguyen, Tan Dai
Tan, Zu Yao Jerome
Jeon, Hyungkook
Roxby, Daniel Ninio
Srirangam Ramanujam, Vaibavi
Abstract
The invention relates to methods and devices for size-based separation of undifferentiated cells from a population of cells using curvilinear microfluidic channels. The curvilinear microfluidic channels may be a spiral microfluidic channels. The differentiated cells are spinal cord progenitor cells (SCPCs), neural progenitor cells (NPCs) and/or cells differentiated therefrom. The method may comprise flowing an input population of cells through first and second sequentially connected and fluidically communicating curvilinear microfluidic channels, wherein the first channel is coupled to an inlet and the second channel is coupled to one or more outlets, wherein the first curvilinear microfluidic channel has a smaller cross-sectional area than the second curvilinear microfluidic channel.
Systems and methods related to drug delivery are provided. In one arrangement, a fluid is administered to a subject in drinkable form, which can partially or fully solidify in the stomach or another area of the gastrointestinal tract to form a drug release article or composition.
A method can include providing a first neural network connected to a second neural network. The first neural network can represent B+1 and the second neural network can represent electrical properties. The method can include training the first neural network and the second neural network jointly. The method can include determining, from the trained first neural network and the trained second neural network B+1, a prediction of and electrical properties at one or more predetermined locations. The method can include outputting the prediction of B+1 and EP.
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
19.
FUNCTIONAL OLIGOMERS AND FUNCTIONAL POLYMERS INCLUDING HYDROXYLATED POLYMERS AND CONJUGATES THEREOF AND USES THEREOF
The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups, e.g., —OH and/or —CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers May be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.
C08F 232/08 - Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
C08F 234/02 - Copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain and having one or more carbon-to-carbon double bonds in a heterocyclic ring in a ring containing oxygen
20.
Greater than Binary State Digital Logic for Superconductive Circuits
In some embodiments, a multistate memory cell includes; a storage loop comprising one or more superconducting devices and one or more inductive devices, the storage loop configured to maintain a quantized magnetic field representing a stored state of the multistate memory cell, the stored state from among a set of three or more distinct digital states; and at least three address lines each inductively coupled to the storage loop, wherein, in response to currents applied to the at least three address lines, the inductive couplings of the at least three address lines combine to force the quantized magnetic field to represent a particular one of the three or more distinct digital states.
G11C 15/04 - Digital stores in which information comprising one or more characteristic parts is written into the store and in which information is read-out by searching for one or more of these characteristic parts, i.e. associative or content-addressed stores using semiconductor elements
G11C 11/06 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using single-aperture storage elements, e.g. ring coreDigital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using multi-aperture plates in which each individual aperture forms a storage element
G11C 11/44 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using super-conductive elements, e.g. cryotron
Disclosed are methods for fabricating a porosity gradient electrode. Also disclosed are porous electrodes. In this process, a single-phase mixture of scaffold-forming polymers dissolved in a solvent is driven into two-phases by a non-solvent, yielding a scaffold which can subsequently be thermally annealed into a carbonaceous and electrochemically active material.
A method for group-level decision making via a census includes using an agent controller to determine one or more collective objectives, calculate a preference for each collective objective of the one or more collective objectives, where each preference is associated with an internal opinion, and receive an external opinion from each agent of one or more agents to form a weighted census. The method further includes using the agent controller to update the internal opinion based on the weighted census, select an option based on the internal opinion, select one or more actions corresponding to the selected option, and perform the one or more actions via the agent controller.
Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The invention, in some aspects, includes systems, methods and components of molecular recorders that encode the timing of transcriptional activity into the sequence of RNA, which can then enable a sequencing-based readout of the internal dynamics of cells.
Disclosed herein are methods, compositions, systems, and kits related to functional testing of polypeptide-target interactions, such as antigen/immune receptor interactions, in a single-cell format.
The present disclosure provides branched poly(β-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease.
The present disclosure provides branched poly(β-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease.
An accelerator device architecture for a computing chip includes a secure Boolean shared in-memory circuit for side-channel attack security. A cipher circuit is coupled to the in-memory circuit for bus probing attack security. A physical-unclonable function cell is coupled to the in-memory circuit. The physical-unclonable function cell is configured to generate a security key using memory in the in-memory circuit.
Systems and methods for the manufacture of improved quantum materials are provided. The techniques include generating, using a machine learning model, a regression model of a figure of merit describing the quantum material, the regression model being determined based at least in part on the characterized one or more quantum properties of individual samples of the quantum material and associated fabrication parameters. The techniques also include determining improved fabrication parameters using the regression model of the figure of merit and fabricating a new sample of the quantum material using the improved fabrication parameters.
G16C 10/00 - Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
G16C 20/70 - Machine learning, data mining or chemometrics
Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3′ Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5′ Group I self-splicing intron fragment.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
30.
METAL MATRIX COMPOSITES AND METHODS OF FORMULATING THE SAME
Metal matrix composites that include a base metal material and a ceramic additive to form composites strengthened by the additives to improve performance in extreme environments are disclosed. Typically the additive is about 2% of the total volume, up to about 10% of the total volume. The particle sizes are typically less than about 100 micrometers, and average about 40 micrometers, while maintaining a spherical shape of the same. The resulting composites can be used to print components for use in extreme environments, such as using additive manufacturing techniques like laser powder bed fusion. Techniques for formulating these composites, and for printing the resulting components using the composites, are also provided.
B33Y 70/10 - Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
C22C 29/00 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides
C22C 29/06 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides based on carbides or carbonitrides based on carbides, but not containing other metal compounds
C22C 29/14 - Alloys based on carbides, oxides, borides, nitrides or silicides, e.g. cermets, or other metal compounds, e. g. oxynitrides, sulfides based on borides
The present disclosure relates to improved metering hoppers for dispensing solid materials, particularly in the context of metered dispensation of solid pellets to feed reactors, in addition to associated methods, systems, and apparatuses. The disclosure relates, in various embodiments, to shielded metering hoppers configured to control the flow of solid material to a feed slot. In some cases, the disclosure relates to pressurized metering hoppers suitable for dispensing solid fuel into gas-generating reactors. Accordingly, the disclosure also relates to pressurized metering hoppers for solid materials, according to some embodiments.
Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IscB polypeptides, novel IscB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are rovided.
The present disclosure provides immunomodulatory fusion proteins comprising a collagen-binding domain operably linked to an immunomodulatory domain. The disclosure also features compositions and methods of using the same, for example, to treat cancer.
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
In some embodiments, a reactor and/or related may generate pressurized hydrogen within an internal volume by combining water and a water reactive material. In some embodiments, the reactor may include a flexible porous membrane configured to contain water reactive material disposed in an internal volume. In some embodiments, the reactor may include a support configured to support a water reactive material in an internal volume.
B01J 19/18 - Stationary reactors having moving elements inside
C01B 3/10 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents with metals by reaction of water vapour with metals
In some embodiments, electric thrusters and/or related methods may form bubbles with a liquid shell and a gas core. The bubbles may be electrically charged, and an accelerating potential is applied to the electrically charged bubbles to generate thrust.
The present disclosure is directed to systems, compositions, and methods for manufacturing objects with sharp edges having a high strength and hardness. To form the sharp edge, an object can be subjected to a compressive force that locally deforms the object to create the sharp edge. In some embodiments, deformation can occur by passing the material through a system of one or more opposed tapered rolls having one or more tapering angles for deforming the material. The tapered rolls can rotate and drive the material downstream to a next opposed pair of tapered rolls. The tapered rolls deform the material by changing the material microstructure, compressing the grains of the material in a predetermined location to create a more homogeneous microstructure. The local modification of the resulting microstructure increases the homogeneity as well as the hardness and strength of the material and prevents cracking and/or chipping of the material.
B21B 1/22 - Metal rolling methods or mills for making semi-finished products of solid or profiled cross-sectionSequence of operations in milling trainsLayout of rolling-mill plant, e.g. grouping of standsSuccession of passes or of sectional pass alternations for rolling bands or sheets of indefinite length
B21C 37/00 - Manufacture of metal sheets, rods, wire, tubes, profiles or like semi-manufactured products, not otherwise provided forManufacture of tubes of special shape
B21J 1/02 - Preliminary treatment of metal stock without particular shaping, e.g. salvaging segregated zones, forging or pressing in the rough
B24B 3/36 - Sharpening cutting edges, e.g. of toolsAccessories therefor, e.g. for holding the tools of cutting blades
Provided herein are non-PEGylated lipid nanoparticles comprising an outer polyanionic layer, compositions thereof, and methods of using said particles or compositions for therapeutic applications.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
38.
Viscoelastic Inorganic Glass Solid Electrolytes For Lithium Or Sodium Batteries
Described herein is a viscoelastic inorganic glass solid electrolyte material, comprising: LixAlEyGzJm, or NaxAlEyGzJm, wherein E denotes one or more elements selected from the group consisting of boron (B), phosphorus (P), silicon (Si), lanthanum (La), or cerium (Ce), G is a chalcogen element, J is a halide element, and wherein 0
Apparatus and methods for robust exoatmospheric positioning are described. Intensity modulated direct detection distance ranging can be used between a space-going craft and reflective satellites for accurate position estimation and guidance of the spacecraft along an intended flight path.
G01S 19/27 - Acquisition or tracking of signals transmitted by the system creating, predicting or correcting ephemeris or almanac data within the receiver
G01S 19/23 - Testing, monitoring, correcting or calibrating of a receiver element
G01S 19/49 - Determining position by combining or switching between position solutions derived from the satellite radio beacon positioning system and position solutions derived from a further system whereby the further system is an inertial position system, e.g. loosely-coupled
G04F 5/14 - Apparatus for producing preselected time intervals for use as timing standards using atomic clocks
40.
WIDE-RANGE SWITCHED-MODE POWER AMPLIFIER ARCHITECTURE
According to one embodiment, a power amplifier includes a plurality of switches and an output tank network. One or more of the switches are configured to generate one or more first intermediate waveforms having one or more first fundamental frequency components, and one or more of the switches are configured to generate one or more second intermediate waveforms by chopping the one or more first intermediate waveforms with controllable timing. The second intermediate waveforms have one or more second fundamental frequency components that are controllably reduced from those of the one or more first intermediate waveforms. The output tank network is configured to filter the one or more second intermediate waveforms to provide an output waveform to a load, the output waveform having one or more third fundamental frequency components. In some cases, all switches achieve zero voltage switching under different power and load conditions with resistive and reactive loads.
Described herein are multi-specific binding agents that bind A33 and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Also provided herein are methods of using multi-specific binding agents or compositions thereof for the detection, prevention, and/or therapeutic treatment of diseases characterized by expression of the A33 glycoprotein antigen, in particular, colorectal cancer.
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
Described in certain exemplary embodiments herein are engineered Anti-CRISPR (Acr) polypeptides and delivery systems engineered for delivery to the cytosol and/or nucleus of cells. In certain embodiments, an engineered Acr polypeptide comprises an Acr polypeptide operatively coupled to a cargo delivery molecule, wherein the cargo delivery molecule is capable of binding or otherwise interacting with a pore-forming polypeptide. Also described in certain exemplary embodiments are methods of Acr delivery to cells via the engineered Acr polypeptides and delivery systems of the present disclosure.
This disclosure provides a method for imaging lymph nodes and lymphatic vessels without a contrast agent. The method includes providing, using an optical source, an infrared illumination to a region of a subject having at least one lymphatic component, detecting a reflected portion of the infrared illumination directly reflected from the region using a sensor positioned thereabout, and generating at least one image indicative of the at least one lymphatic component in the subject using the reflected portion of the infrared illumination.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
What is described herein is a device for sensing a target, comprising a planar array of unique stochastic sensors, wherein each sensor is weakly cross-reactive with a unique determinant on the target; a means for capturing electrical signals from each sensor and the temporal duration of each signal; and a means for analyzing the cumulative signals from the array of stochastic sensors, and optionally further comprising a computer system for processing an algorithm for identifying the target based on the electrical signals from the sensors of the device.
What is disclosed herein are quadrupole mass filters (QMF) and related methods. The QMFs may have a relatively high surface roughness and/or be additively manufactured, wherein the QMF may be configured for ion filtering in a mass spectrometer. The methods may comprise: a. applying transverse sections to produce a dielectric part; b. masking one or more surfaces of the dielectric part to produce a partially masked dielectric part; c. positioning a metal on the partially masked dielectric part with a metal conductor to produce one or more electrically conductive surfaces on the printed part; and d. removing the mask from the printed part to produce a finished QMF; wherein the QMF is configured for ion filtering in a mass spectrometer.
Devices and methods for controlling a phase transition of a sample are provided. The device includes a heat transfer device adapted to be thermally connected with a sample, where the sample has a first phase and a second phase, with the sample being initially in the first phase; an image acquisition module adapted to acquire an image of the sample; and a control system, operably connected to the heat transfer device and the image acquisition module. The control system is configured to, while a termination condition is not met: cause heat transfer between the heat transfer device and the sample, thereby causing a phase transition of the sample from the first phase to the second phase; cause the acquisition module to acquire the image of the sample; based on the image of the sample, determine the position of a boundary between the first phase and the second phase of the sample; and based on the determined position of the boundary, determine whether the termination condition is met.
G01N 25/04 - Investigating or analysing materials by the use of thermal means by investigating changes of state or changes of phaseInvestigating or analysing materials by the use of thermal means by investigating sintering of melting pointInvestigating or analysing materials by the use of thermal means by investigating changes of state or changes of phaseInvestigating or analysing materials by the use of thermal means by investigating sintering of freezing pointInvestigating or analysing materials by the use of thermal means by investigating changes of state or changes of phaseInvestigating or analysing materials by the use of thermal means by investigating sintering of softening point
G01N 1/44 - Sample treatment involving radiation, e.g. heat
An initial protein sequence is identified and varied to generate a plurality of variants. An activity of the plurality of protein sequences is measured quantitatively. Each of the plurality of protein sequences is provided as an input to a large language model (LLM) to generate a corresponding plurality of embeddings in a latent space. A subset of the plurality of embeddings is used to train a top layer model. The plurality of embeddings are provided as inputs to the top layer model to generate outputs representing predictions of the activity of the plurality of protein sequences. A subset of the plurality of protein sequences is selected based on the top layer model outputs. The method repeats, with the selected subset of the plurality of protein sequences playing the role of the initial protein sequence in the initial iteration, until some termination criterion is satisfied.
In one embodiment, a method includes obtaining, by one or more sensors of a wearable device worn by a user, one or more biological signals of the user and determining, based on the one or more biological signals, a current sleep stage of the user. The method further includes determining, based at least on the determined sleep stage of the user, whether to provide a stimulation to the user; and in response to a determination to provide a stimulation to the user, then providing, by one or more electronic devices in the environment of the user, the stimulation to the user.
The techniques described herein relate to systems, apparatus, articles of manufacture, and methods for training robots for dexterous manipulation tasks. An example apparatus for training a robotic system includes an end effector configured to manipulate an object, a passive exoskeleton configured to be manipulated by a portion of a user's body to change one or more parameters of the end effector, one or more linkages coupling the end effector to the passive exoskeleton, wherein the one or more linkages transmit forces applied to the end effector, due to interactions of the end effector with a surrounding environment comprising the object, to the portion of the user's body through the passive exoskeleton, and one or more sensors coupled to the end effector and configured to sense the one or more parameters of the end effector, and output one or more signals indicative of the one or more parameters.
Systems and methods for electrochemical target species separation are described herein. In some embodiments, a target species can be transported, in response to an applied voltage, from a fluid in a first electrically conductive tube (e.g., a tubular electrode) that has a low concentration of the target species to a fluid in a second electrically conductive tube (e.g., a tubular electrode) that has a high concentration of the target species. The transport of the target species may involve the diffusion of the target species through porous walls of the first and second tube. In some embodiments, the target species comprises gases such as acid gases (some of which may be commonly exhausted from powerplants and/or industrial processes).
B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
Rapid charging and high energy density are valuable battery attributes. However, high performance batteries with both of these attributes can be difficult to achieve. Conventional high performance batteries rely on metal-based electrodes including materials that can be difficult to source. Batteries with high capacity, even during rapid charge-discharge cycling, are herein provided. According to some embodiments, a battery provided herein includes an organic electrode and an organic, non-aqueous solvent system. Constituents of the organic electrode may be additionally advantaged by the comparative case with which they may be sourced.
Described herein are engineered, non-naturally occurring systems and compositions comprising multimeric CRISPR-Cas complexes comprising a β-CASP polypeptide, a plurality of Cas polypeptides, and a guide molecule, packaging and delivery systems thereof, and methods of use thereof, for modifying target polynucleotides. In addition, described herein are engineered, non-naturally occurring systems and compositions comprising a class of small Cas proteins (Type II-B, II-C, and II-D Cas proteins) and methods of modifying target sequences using the Type II-B, II-C, II-D Cas proteins and systems thereof.
Described are concepts directed toward systems, structures and techniques to create low-resistance, high current capacity, demountable solder joint connections. Such systems, structures and techniques may be used to simultaneously create low-resistance, high current capacity, demountable solder joint connections at multiple locations between no insulation (NI) superconductors and in particular between NI high temperature superconductors (HTS) such as may be used in NI-HTS magnets.
A method for visual representation includes receiving a point cloud of an environment. The method also includes processing the point cloud at multiple levels of detail to produce multi-level data, the multi-level data including simplified geometric descriptions of the point cloud and/or a subset of points of the point cloud. The method further includes forming intermediate representations based on the multi-level data. The method still further includes determining features for the intermediate representations based on the simplified geometric descriptions and/or the subset of points. The method also includes generating a visual representation of the environment based on the determined features.
Techniques for detecting embolic information for a patient. The techniques may include obtaining data identifying an ultrasound signal associated with the patient, identifying a set of candidate embolic regions in the data, identifying a set of embolic regions from among the set of candidate embolic regions, and outputting embolic information corresponding to the set of embolic regions.
G01S 7/52 - Details of systems according to groups , , of systems according to group
G01S 15/89 - Sonar systems specially adapted for specific applications for mapping or imaging
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
57.
COMPOSITIONS AND METHODS FOR ENHANCING WNT SIGNALING FOR TREATING CANCER
Methods and compositions for enhancing Wnt signaling pathway activities in a tissue of a subject have been developed for the treatment of cancer, in particular cancers with one or more mutations in the APC (adenomatous polyposis coli) gene. Preferably, the amount of the compositions for enhancing Wnt signaling does not reduce or inhibit proliferation or viability of normal healthy cells in the subject. In some embodiments, pharmaceutical compositions including an effective amount of one or more GSK-3 inhibitors are administered to reduce cancer cell proliferation or viability in a subject. A preferred GSK-3 inhibitor is LY2090314 encapsulated within, or associated with nanoparticles. Dosage forms of LY2090314 encapsulated within, or associated with nanoparticles for administration are also described.
A61K 31/5517 - 1,4-Benzodiazepines, e.g. diazepam condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
A photonic system is provided. The photonic system comprises a first photonic component and a second photonic component. The photonic system additionally comprises a photonic ribbon cable comprising a waveguide extending from a first end of the photonic ribbon cable to a second end of the photonic ribbon cable and having a winding geometry configured to deform, enabling the first end of the photonic ribbon cable to be extended away from the second end of the photonic ribbon cable. The first end of the photonic ribbon cable is optically coupled to the first photonic component and the second end of the waveguide is optically coupled to the second photonic component.
G02B 6/293 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means
G02B 6/42 - Coupling light guides with opto-electronic elements
59.
UNIFIED GRAPH TRANSFORMER FOR FINANCIAL FRAUD DETECTION ON MASSIVE GRAPHS
A computer-implemented method for modeling graph-structured data using a graph transformer includes applying cross-type attention to a target node of the graph-structured data. The graph transformer is connected to a type-specific feed forward network to allow node features of different node types to be learned differently. Masked label embedding is applied to force learning and a prediction of a node label for a node having a masked label.
A photonic system including a cantilever, the cantilever including a plurality of waveguides spaced from one another in a width of the cantilever to project a plurality of respective beams, the plurality of respective beams spaced with a uniform pitch from one another along a dimension of the width, and a piezoelectric layer, the photonic system including one or more voltage sources to apply a voltage across the piezoelectric layer, such that the cantilever deflects along a length of the cantilever when the voltage is applied and a controller to drive the voltage to cause a center point of a tip of the cantilever to translate in a two-dimensional Lissajous pattern.
Qubit arrays, such as neutral atom arrays and ion arrays, provide versatile platforms for quantum information processing. However, in large-scale arrays, efficient photon collection remains a bottleneck for fast, non-destructive qubit readout and remote entanglement distribution. Our cavity-based approach enables fast, parallel operations over many qubits using multiple modes of a single optical cavity. By selectively shifting the relevant atomic transitions, each qubit can be coupled to a distinct cavity mode, allowing independent simultaneous processing. Practical systems support cavity-mode multiplexing with large numbers of modes, enabling rapid mid-circuit syndrome extraction and significantly enhancing entanglement distribution rate between remote atom arrays. Our technology provides a scalable solution to core challenges in qubit arrays, advancing the development of practical quantum technologies.
An apparatus comprising at least one photonic crystal cavity includes a grating comprising a first dielectric material and a nanobeam comprising a second dielectric material deposited on a surface of the grating, wherein a longitudinal axis of the nanobeam is oriented at a non-parallel angle to the grating. A photonic system comprises a photonic crystal cavity comprising a dielectric grating and a dielectric nanobeam deposited on a surface of the grating. A longitudinal axis of the nanobeam is oriented in a non-parallel arrangement to the grating, and a first distal region of the photonic crystal cavity is affixed to a substrate. A piezoelectric component comprises a free-floating distal region connected to a second distal region of the photonic crystal cavity. A voltage source is configured to apply a voltage to the piezoelectric component, generating strain in the photonic crystal cavity.
G02F 1/295 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection in an optical waveguide structure
Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3′ Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, and d) a 5′ Group I self-splicing intron fragment.
C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
C12N 15/11 - DNA or RNA fragmentsModified forms thereof
Analog optical neural networks (ONNs) can reduce the energy of matrix-vector multiplication in neural network inference below that of digital electronics. However, realizing this promise remains challenging due to digital-to-analog (DAC) conversion—even at low bit precisions b, encoding 2b levels of digital weights and inputs into the analog domain involves power-hungry electronics. Faced with similar challenges, telecommunications uses complex-valued Quadrature-Amplitude Modulation (QAM). QAM maximally exploits the complex amplitude to provide a quadratic 0(N2)→0(N) energy saving over intensity-only modulation. QAMNet, an ONN with lower energy consumption than existing ONNs, uses the complex nature of the amplitude of light with QAM. QAMNet accelerates complex-valued deep neural networks with accuracies indistinguishable from digital hardware. Compared to standard ONNs, QAMNet ONNs are (1) more accurate above moderate levels of total bit precision, (2) more accurate above low energy budgets, and (3) an optimal choice when hardware bit precision is limited.
Disclosed herein are fingers for gripper assemblies. The finger includes a gripper pad. The finger includes a mirror panel facing the gripper pad. The finger includes a first window extending between the gripper pad and the mirror panel. The finger includes a camera oriented to collect image data that includes a reflected view of gripper pad from the mirror and a view through the first window.
A system and method for simulating all-atom molecular dynamics using a novel approach that leverages Special Orthogonal Group 3—equivariant stochastic interpolants. The method allows for efficient and accurate simulations across large time steps while maintaining detailed atomic representations. Unlike traditional methods, this approach is trained on the direct transfer of distributions between consecutive time steps, bypassing the need to predict the Boltzmann distribution and avoiding the complexities of force integration. The method is also designed to be transferable across different molecular systems, generalizing from training on a subset to a broader range. Additionally, the invention incorporates mirror interpolants to predict dynamics within the same time step, followed by sampling from a Boltzmann distribution and simulating time dynamics using Langevin dynamics. This approach provides a highly efficient and scalable solution for simulating all-atom molecular dynamics, applicable to a wide range of molecular systems.
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
67.
Three-Dimensional Modular Asynchronous Parallel Computer and Methods of Construction Therefor
A computer system consists primarily of identical modular microcontroller units, interconnecting with one another in a three-dimensional lattice. During operation, each microcontroller communicates asynchronously by relying on token-passing between itself and its neighbors. Programming and construction of such microcontroller units occurs in one operation, through robotic pick-and-place operations that are configured through a graphical user interface. The graphical user interface includes simple drag and drop operations to facilitate a WYSIWYG depiction of the desired build and the final system. The design tools and automated assembly of the disclosed framework introduces system scalability and structural flexibility that are not available with existing supercomputing racks and chassis.
G06F 15/80 - Architectures of general purpose stored program computers comprising an array of processing units with common control, e.g. single instruction multiple data processors
68.
SYSTEMS AND METHODS FOR PREVENTING, MITIGATING, AND/OR TREATING DEMENTIA
Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.
A61M 21/00 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
The present disclosure provides, in some aspects, macromonomers of Formula (I), and salts thereof; methods of preparing the macromonomers, and salts thereof; Brush prodrugs (polymers); methods of preparing the Brush prodrugs; compounds of Formula (II); conjugates of Formula (III), and salts thereof; pharmaceutical compositions comprising a Brush prodrug, or a conjugate or a salt thereof; kits comprising: a macromonomer or a salt thereof, a Brush prodrug, a compound, a conjugate or a salt thereof, or a pharmaceutical composition; methods of using the Brush prodrugs, or conjugates or salts thereof; and uses of the Brush prodrugs, and conjugates or salts thereof. These chemical entities may be useful in delivering pharmaceutical agents to a subject or cell.
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/475 - QuinolinesIsoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
A61K 31/502 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
C08G 61/08 - Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
70.
STRONG, MODULAR, AND PROGRAMMABLE PLATE LATTICES HAVING KIRIGAMI CORRUGATIONS
Custom folded 3-dimensional plate lattices are modularly assembled to form structures with single and double curvature for use in structural engineering and robotics applications. The plate lattice structural corrugation uses a building block strategy and incorporates custom modified unit cells based on a Kirigami Expanded Miura pattern. This transformation involves expanding the top and bottom zig-zag crease lines into facets and orienting them in space. The structure of these lattices allows for the design of anisotropies in their flexural stiffness by alternating between the Maxwell criterion on bending-dominated and stretch dominated cells. These anisotropies can have value differences of up to 24 times with the same geometry, making them ideal for robotic morphing applications.
B32B 3/28 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer comprising a deformed thin sheet, e.g. corrugated, crumpled
B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
B29C 48/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired formApparatus therefor
B32B 15/085 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin comprising polyolefins
B32B 15/20 - Layered products essentially comprising metal comprising aluminium or copper
Described herein is a molten-salt Na—O2 battery which includes a first electrode including liquid Na in direct contact with a solid-state electrolyte; and a composite second electrode in contact with the solid-state electrolyte, wherein the composite second electrode includes: particles having an oxygen-active metal surface; and a molten salt comprising redox-active ions; and O2 in contact with the composite second electrode; where the solid-state electrolyte is disposed between the first electrode and the composite second electrode. Methods of making the battery and methods of producing electricity with the battery are also described.
H01M 4/36 - Selection of substances as active materials, active masses, active liquids
H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 10/054 - Accumulators with insertion or intercalation of metals other than lithium, e.g. with magnesium or aluminium
Described herein are techniques for designing proteins for binding to a target. In some embodiments, the techniques include: obtaining an amino acid sequence for a candidate protein that binds to the target with a candidate binding affinity; determining, for proteins in a set of proteins, probabilities that binding affinities between the proteins and the target are greater than the candidate binding affinity, and identifying a subset of the set of proteins based on the determined probabilities. Determining a first probability that a first binding affinity between a first protein and the target is greater than the candidate binding affinity may include: processing a first amino acid sequence of the first protein using a trained machine learning model to obtain a first output indicative of the first binding affinity; and determining the first probability using the first output indicative of the first binding affinity between the first protein and the target.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Aspects of the invention in particular relate to Cpf1 mutants having altered PAM specificity.
Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
Described herein are methods of generating engineered viral capsid variants. Also described herein are engineered viral capsid variants, engineered viral particles and formulations and cells thereof. Also described herein are vector systems containing an engineered viral capsid polynucleotide and uses thereof.
A novel family of die steels is disclosed. This family of die steels is strengthened through the formation of M2C precipitates and one or two additional precipitates, wherein M is one or more of chromium (Cr), vanadium (V), molybdenum (Mo) or tungsten (W). These additional precipitates may include copper precipitates, NiAl precipitates, and Ni(Al1-xMnx) precipitates. This creates a steel having an acceptable hardness, as well as excellent thermal conductivity.
The present disclosure relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipid and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
Current machine learning methods for target binding oligonucleotides design are limited to considering natural sequences in the targets. Here, Applicants generated novel target binding oligonucleotides—with multiple mismatches to any natural sequence—that are optimized for desired properties. These novel target binding oligonucleotides offer more sensitive and specific detection of, for example, pathogen genome variation than baseline design methods, and they illuminate a new, interpretable design rule that broadens nucleic acid sequence targeting.
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
79.
CONTINUOUS EMISSIONS MONITOR FOR DIRECTED-ENERGY BOREHOLE DRILLING
Apparatus and methods for monitoring emissions from a borehole to determine the composition of earthen material removed from the borehole are described. Monitoring can be done in real time as the borehole is being deepened with a millimeter-wave drilling beam.
G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
E21B 7/15 - Drilling by use of heat, e.g. flame drilling of electrically generated heat
E21B 49/00 - Testing the nature of borehole wallsFormation testingMethods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
80.
RECONFIGURABLE ANALOG CURRENT-DOMAIN IN-MEMORY COMPUTE SRAM DESIGN FOR LOW-POWER APPLICATIONS
A static random-access memory (SRAM) device a read-port coupled to a voltage-to-time (VTC) conversion block. The read-port comprises a first transistor coupled to a pair of cross-coupled inverters. A pass gate transistor is coupled to the first transistor. A current-source transistor is coupled to the pass gate transistor. A row of the SRAM device is configured to generate a read wordline signal multiplied by one or more SRAM stored weights in response to receiving a voltage vector. The row is further configured to generate analog outputs for a multiply and compute operation (MAC).
A respiratory monitoring system with improved detection of oxygen consumption is described. The system uses one or two mixing chambers and samples gases at selective locations for reliable detection of oxygen over extended periods of time with autonomous detection of calibration drift. The system can be used for indirect calorimetry and monitoring health of a subject.
The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.
C07C 29/14 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of a —CHO group
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ≤1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance >94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 9/04 - Layered products essentially comprising a particular substance not covered by groups comprising such substance as the main or only constituent of a layer, next to another layer of a specific substance
E06B 9/24 - Screens or other constructions affording protection against light, especially against sunshineSimilar screens for privacy or appearance
An eyedrop assist device is configured for use with an eyedrop bottle in an environment defining a horizontal. To that end, the eyedrop assist device has a body with a proximal end and a distal end. Importantly, the body has a receiving region to receive the eyedrop bottle and forming a longitudinal axis. The eyedrop assist device also has an angle calibrator configured to produce first indicium identifying when the longitudinal axis of the receiving region forms a first angle, and a tilt sensor. Preferably, the tilt sensor is configured to produce second indicium when the longitudinal axis of the longitudinal axis of the receiving region is tilted to form a second angle relative to the horizontal. Since they are for different purposes, the first and second angles are different angles.
A61F 9/00 - Methods or devices for treatment of the eyesDevices for putting in contact-lensesDevices to correct squintingApparatus to guide the blindProtective devices for the eyes, carried on the body or in the hand
A61B 17/00 - Surgical instruments, devices or methods
85.
POWER CONVERTER WITH CAPACITIVE ENERGY TRANSFER AND FAST DYNAMIC RESPONSE
A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. The converter can be used, for example, to power logic devices in portable battery operated devices.
H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
H02M 3/07 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode
H02M 3/155 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
C07C 229/30 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
C08G 63/66 - Polyesters containing oxygen in the form of ether groups
In some embodiments, a reactor and/or related methods may produce pressurized hydrogen gas by combining a reactant and water within a reactor chamber. The hydrogen gas may be siphoned from the reactor and used in associated systems.
B01J 8/08 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with moving particles
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
C01B 3/08 - Production of hydrogen or of gaseous mixtures containing hydrogen by reaction of inorganic compounds containing electro-positively bound hydrogen, e.g. water, acids, bases, ammonia, with inorganic reducing agents with metals
88.
COMPOSITIONS AND METHODS FOR TARGETING DENDRITIC CELL LECTINS
Compositions and methods of glycosylated virus-like particles (VLPs) displaying user-defined antigens and optionally encapsidating TLR ligands for targeting dendritic cell lectins have been developed. The VLPs employ ligands for a DC lectin e.g., DC-SIGN to activate dendritic cells (DC) and drive proliferation of antigen-specific CD8 and CD4-T cells specific for a user-defined antigen, such as a tumor antigens. In some forms, the compositions include aryl-mannose ligands to effectively generate DC-mediated TH-1 T cell responses to the user-defined antigen.
Described is a multi-output tunable matching networks (MOTMN) that can transfer energy from a single input to multiple outputs with varying load impedances coupled thereto while controlling one or more of: (1) an impedance (ZIN) seen at the input of the MOTMN; (2) a distribution of rf power to the multiple outputs of the MOTMN; and (3) phases (including relative phases) of rf signals propagating through the MOTMN.
A dataset of linkage mechanisms is obtained and an input representation of a given target curve is received. The dataset is searched to identify one or more linkage mechanisms of the dataset that approximate the input representation using computational techniques. The one or more identified linkage mechanisms are refined based on a global optimization algorithm and modifications are applied to the one or more refined linkage mechanisms using a butterfly extension. The one or more modified linkage mechanisms are presented as one or more digital three-dimensional models, respectively.
G06F 30/17 - Mechanical parametric or variational design
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
91.
Thermal Radiation Shield For A Superconducting Magnet
Described are structures and techniques for supporting a thermal radiation shield in a superconducting magnet. The thermal radiation shield can be supported off of a cold mass using low thermal conductivity structural supports. Structural supports, specifically thermal radiation shield supports and bumpers, may be installed between a cold mass and the radiation shield to mitigate deflections of the radiation shield. Thermal radiation shield supports are attached to both the cold mass and the radiation shield. Bumpers may be used in addition to thermal radiation shield supports and have a first end attached to either the cold mass or the thermal radiation shield and a second end not physically coupled to any structure.
Electric machines and related methods are generally described. In some embodiments, an electric machine may be integrated with a thermal management system for high specific power output performance. The construction and operational parameters of the systems may be 5 precisely designed to achieve high specific power outputs between 10 kW/kg and 25 KW/kg. The thermal management system may include a heat exchanger integrated directly into the electric machine for enhanced thermal transport out of the system. A fluid (e.g., air) may flow through various flow paths throughout the system to increase cooling of the system.
H02K 9/22 - Arrangements for cooling or ventilating by solid heat conducting material embedded in, or arranged in contact with, the stator or rotor, e.g. heat bridges
H02K 9/10 - Arrangements for cooling or ventilating by gaseous cooling medium flowing in closed circuit, a part of which is external to the machine casing
93.
Opto-Electronic Chiplets for Scalable Coherent Interconnects to Zero-Change VLSI Electronics
Optical chiplets can be mounted to zero-change VLSI chips to form an integrated electro-optical device. Control signals for controlling active optical devices on the optical chiplets can be provided from the VLSI chip and coupled to the active optical devices on the optical chiplets. The technology provides small-area, low-energy, RF optical interfaces for VLSI chips.
G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
G02F 1/03 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect
94.
Direct-drive Electrodialysis Separation Using Flow-commanded Current Control
An electrodialysis system controller is configured to be coupled to a power supply, and powered devices that include a pump, and an electrodialysis unit. The controller receives inputs including an input indicative of a flow rate through the electrodialysis unit, an input indicative of a concentration level of fluid in the electrodialysis unit, and an input indicative of a power differential (e.g., indicating a degree to which a power usage by the powered devices differs from available power of the power source), and provides outputs for controlling the powered devices, including an output for causing a variable current level to be applied in the electrodialysis unit, and an output for causing a variable fluid flow rate through the electrodialysis unit. The controller is configured to match the power usage to the available power, for example, to keep the power differential as small as possible, while maximizing the theoretical desalination rate of the electrodialysis system.
C02F 1/00 - Treatment of water, waste water, or sewage
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
95.
LINE SCANNING TEMPORALLY FOCUSED TWO-PHOTON LITHOGRAPHY SYSTEM
The present invention presents improved systems and methods for performing multi-photon lithography. A line-scanning temporally focused two-photon lithography (LS-TFTPL) technique is capable of patterning three-dimensional structures with high throughput. An example LS-TFTPL system may include a pulsed laser, first optical components for expanding light pulses into an elongated or line cross section, a digital micromirror device for modulating the light pulses with a linear pattern and dispersing spectral components of the modulated light pulses, and second optical components for focusing the dispersed spectral components of the modulated light pulse at a line in or on a target material. The focused spectral components may alter the target material within selected voxels along the line, where the selected voxels spatially correspond to the linear pattern.
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for
Systems, compositions, and methods related to injectable hydrogels are generally described. In some embodiments, a composition comprises a first polymer and a plurality of particles comprising a second polymer capable of forming a hydrogel at elevated temperatures, such as body temperature. The plurality of particles (e.g., hydrogel particles) may comprise an active substance, such as a biological material and/or a therapeutic agent. Together, the first polymer and the second polymer may interact with each other (e.g., the first polymer may interpenetrate the second polymer, and/or the first polymer may cross-link with the second polymer) at elevated temperatures to form a hydrogel. Interactions between the first and second polymer, and/or between hydrophobic domains thereof, may facilitate the relatively slow and/or controlled release of the active substance. In some embodiments, the plurality of particles may have advantageously high loadings of biological materials (e.g., antibodies, proteins, peptides).
The present disclosure features methods for modifying fertility. In some embodiments, the disclosure provides contraceptive compositions and methods of using the same.
Disclosed herein is a cathode for a lithium-ion battery having a formula:
Disclosed herein is a cathode for a lithium-ion battery having a formula:
Li2+u-vM2-u[XO4]xO4(1-x) where, 0≤u≤1, 0≤v≤2 and 0≤x≤1, wherein M is a transition metal element of manganese or a mixture of manganese and iron, and X is an element of phosphorus, silicon, sulfur, boron, or a mixture of these elements.
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
C01B 25/45 - Phosphates containing plural metal, or metal and ammonium
Meta-optic systems are described that include multi-function metasurfaces formed from a plurality of meta-atoms. A multi-function metasurface can exhibit two or more different optical functions for two or more different states of light incident on the metasurface. Different states of light include different polarizations, different wavelengths, and different angles of incidence. Different optical functions include distance sensing, converging, diverging, image formation, and patterned light formation. The multi-function metasurface can selectively impart different phase profiles to an incident beam depending on the incident beam's state of light.
G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
H04N 23/958 - Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging
patents
