B82Y 15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
2.
Utilization Of Halides To Improve Diamond Properties
Described herein is a diamond and diamond products comprising:
a NV0 or SiV0 defect, wherein the NV0 or SiV0 defect comprises a nitrogen atom or silicon atom replacing a carbon atom in the diamond and a neutral vacancy replacing a carbon atom adjacent to the nitrogen atom or silicon atom in the diamond;
a NV− or SiV− defect, wherein the NV− or SiV− defect comprises a nitrogen atom or silicon atom replacing a carbon atom in the diamond and a negatively-charged vacancy replacing a carbon atom adjacent to the nitrogen atom or silicon atom in the diamond; and
a halide atom.
Described herein are targeting moieties that can be capable of specifically targeting muscle cells and can include an n-mer motif. In some embodiments, the n-mer motif contains an RGD motif. Also described herein are vector systems, particles, polypeptides that can encode and/or contain one or more targeting moieties. Also described herein are methods of delivering a cargo to a cell, such as a muscle cell, using one or more of the targeting moieties described herein.
A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The present disclosure provides compositions which enable the delivery of cargo, including therapeutic agents such as RNA, to organs or tissues in addition to the liver, lungs, and spleen, such as brain, heart, kidney, and muscle tissue. More specifically, the compositions comprise a plurality of lipid particles comprising an agent, cationic lipids and ionizable lipid.
Microstructures, their use, and methods for making microstructures are provided, where the methods involve applying an external stimulus to a plurality of packed, polymeric microspheres, wherein the polymeric microspheres have a porosity of between about 20% to 99%, and wherein at least a boundary layer of the polymeric microspheres are in contact with a surface; such that the polymeric microspheres collapse into smaller and denser microspheres that join with adjacent microspheres at contact points to form a micronetwork, wherein the contact points comprise microstructures extruded from the polymeric microspheres.
B01J 13/02 - Making microcapsules or microballoons
B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
SYNTHESIS OF ESTER, CARBONATE, AND CARBAMATE-DERIVED NOVEL BIODEGRADABLE IONIZABLE LIPIDS FROM METHYL RICINOLEATE OR METHYL 12-HYDROXYSTEARATE AND ITS APPLICATIONS
Provided herein are compounds, such as compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, and isotopically labeled derivatives thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are lipids useful for delivery of polynucleotides, such as mRNA, for the treatment and/or prevention of various diseases and conditions (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, liver disease, spleen disease, lung disease, painful condition, psychiatric disorder, musculoskeletal disease, a metabolic disorder, inflammatory disease, or autoimmune disease).
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
C07C 229/12 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
C07C 229/16 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
C07D 207/06 - Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 255/02 - Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups not condensed with other rings
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
7.
Methods and Apparatus for Imaging with Conformable Ultrasound Patch
An ultrasound patch may conform to a curved surface of a large, curvilinear part of a human body, and may capture ultrasound images of underlying tissue for detection of disease. The patch may comprise a flexible, elastomeric substrate, in which phased arrays of piezoelectric ultrasound transducers are embedded. The phased arrays may steer ultrasound beams through a wide angle to image a large volume of tissue. Mechanical deformation of the flexible substrate as it conforms to a curvilinear body part may change the relative 3D positions of the phase arrays. However, localization may be performed to detect these 3D positions. Data captured by the phased arrays may be processed, to create an ultrasound image of the underlying tissue. A semi-flexible, intermediate layer may partially encapsulate each phased array, to distribute stress at an interface between the rigid phased array and more flexible substrate.
The use of elongated nanostructures in separators and associated devices and methods, including devices and methods for energy storage and/or use, are generally described. According to certain embodiments, the elongated nanostructures can extend from a first solid substrate to a second solid substrate. In some embodiments, the nanostructures penetrate a surface of the first solid substrate (e.g., a first electrode) and/or a surface of the second solid substrate (e.g., a second electrode). The elongated nanostructures can, according to certain embodiments, provide structural reinforcement between two substrates (e.g., between two electrodes) while maintaining electronic insulation between the two substrates.
A clutch device includes two pluralities of flexible members interleaved with each other. An overlapping region is defined where the flexible members overlap each other. Non-overlapping regions are on opposing sides of the overlapping region. The non-overlapping regions are regions in which the flexible members do not overlap each other. In a locked arrangement, an outer portion of each non-overlapping region extends at a first angle relative to the overlapping region. The first angle causes the flexible members to engage and interlock with each other. The outer portions of can be moved to a second angle different than the first angle to unlock the clutch device and allow the flexible members to disengage with and be separated from each other. The clutch device thus does not require continuous energy input while also having a high locking force that can be rapidly applied or released.
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
Systems, devices, and methods for the detection of analytes such as per- and polyfluoroalkyl substances (PFAS) in samples are generally described. Certain aspects of the present disclosure are related to systems for detecting analytes in samples. In some embodiments, a cartridge is used that comprises a plurality of microwells. The microwells can comprise, for example, a chamber and an optional cutout section. In some embodiments, the microwell has a volume of 0.001-1,000 pl (e.g., 0.1-100 pl), which can, for example, provide sufficient volume to detect the present of PFAS while also not being so large as to require a long amount of time before producing a result. In certain embodiments, the cartridge comprises a layer domain, which can hermetically seal the microwells. The layer domain can be, in some embodiments, configured to reseal after insertion of a needle.
G01N 9/24 - Investigating density or specific gravity of materialsAnalysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
G01N 9/24 - Investigating density or specific gravity of materialsAnalysing materials by determining density or specific gravity by observing the transmission of wave or particle radiation through the material
Described is a partitioned cable joint comprising a plurality of physically distributed joint elements with the plurality of joint elements taken together defining a joint length. Joint elements may have a first mounting region having a shape selected to accept one petal of superconducting cable and a second mounting region having a shape selected to accept one petal of a second conductor.
Disclosed herein are methods and systems utilizing CRISPR effector systems for assays and diagnostics. Embodiments herein provide tile probes in systems and methods for detection of multiple targets across a given genome or group of genomes, including in circulating nucleic acid samples.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
One or more unit-test cases are generated from a monolingual code corpus and the generated unit-test cases are filtered to generate a corpus of unit-test cases which have acceptability scores exceeding one or more predefined thresholds. One or more of the code samples of the monolingual code corpus are translated from a source language to a target language using a pretrained Large Language Model and the generated unit-test cases are translated from the source language to the target language. The LLM-translated code samples are validated using the translated unit-test cases and a parallel-data training corpus comprising the LLM-translated code samples that pass the validation is created. The pretrained large language model (LLM) is fine-tuned using the parallel-data training corpus, a given code segment is translated using the fine-tuned large language model (LLM), the translated given code segment is tested and the tested given code segment is deployed.
Provided herein are processes for preparing an oligomer (e.g., a morpholino oligomer). The synthetic processes described herein may be advantageous to scaling up oligomersynthesis while maintaining overall yield and purity of a synthesized oligomer.
Mammals rely on adaptive immunity to protect against infections and tumors, with the thymus playing a crucial role by producing T cells that target infected or cancerous cells. The thymus, however, undergoes functional decline with age, significantly impairing the immune system in the elderly. To investigate reversing this decline, compositions and methods for activation and differentiation of T cell progenitors in extrathymic tissues are disclosed that stimulate production of differentiated T cells. For example, LNP-mediated delivery of mRNAs encoding DLL-1, IL-7, and FLT3L to the liver is shown to create a temporary site for T cell maturation that enhances T cell-mediated immunity in aged mice without causing autoimmunity. This approach facilitates ectopic T cell development from hematopoietic precursors and activates dendritic cells, providing evidence that engineering adaptive immunity in vivo can effectively mitigate immune aging.
Described herein are muscle-specific targeting moieties and compositions including the muscle specific targeting motifs. Also described herein are uses of the muscle-specific targeting motifs and compositions including the muscle specific targeting moieties. In some embodiments, the muscle-specific targeting moieties and compositions including the muscle specific targeting moieties can be used to direct delivery of a cargo to a muscle cell.
Systems, devices, or methods described herein may involve a human augmentation device configured to estimate the state of at least one implanted magnetic target. In some example embodiments, the device may comprise an array of sensors configured to measure one or more target field characteristics. In some example embodiments, the device may comprise a processing element configured to acquire measurements of the one or more target field characteristics and apply information-theoretic processing of the measurements to estimate in real-time the state and error covariance of at least one target state vector. In some example embodiments, the device may comprise a processing element configured to control an actuator of the human augmentation device.
An object includes an object body formed from a build material and a marker embedded in a part of the object body. The marker is formed from a fluorescent marker material configured to emit radiation with a first wavelength when exposed to radiation with a second wavelength. The build material in the part of the object body is translucent to radiation with the first wavelength and the second wavelength.
G06K 7/12 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using a selected wavelength, e.g. to sense red marks and ignore blue marks
Provided herein are antisense oligomer conjugates. In one embodiment, the antisense oligomer conjugates comprise a phosphorodiamidate morpholino oligomer (PMO) which is covalently linked to a cell-penetrating peptide (CPP). Also provided herein are methods of treating a muscle disease, such as Duchenne muscular dystrophy, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject one or more of the antisense oligomer conjugates described herein.
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
41 - Education, entertainment, sporting and cultural services
Goods & Services
Educational services, namely, providing science educational mentoring services and programs; providing educational demonstrations; providing training and mentorship in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; developing curriculum for educators; organization of exhibitions for cultural or educational purposes; providing information relating to educational and entertainment activities and events for children; educational services, namely, providing a learning and innovation center featuring fully customized leadership, motivational, educational, and brainstorming training; providing information relating to education services; providing courses of instruction at the kindergarten level; providing courses of instruction at the primary level; providing courses of instruction at the high school level; providing courses of instruction at the undergraduate level; providing courses of instruction at the post-graduate level; educational services, namely, developing, arranging, and conducting educational conferences and programs in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; educational services, namely, providing classes and workshops in the fields of innovation, product design, product development, scientific research, entrepreneurship, problem solving, and business; arranging and conducting educational competitions for students in the fields of science, innovation, product design, product development, and business
23.
SYSTEMS AND METHODS FOR SEPARATION OF CARBON DIOXIDE
Polyamines are water-soluble polyelectrolytes with the amino groups that can be used to attach the polymers onto functional surfaces of fibrous materials. In addition, polyamines can be readily modified by (super)nucleophilic groups such as (alkyl)aminopyridines that enhance the polymer's ability to promote hydrolysis of organophosphorous chemical warfare agents. Furthermore, attachment of hydantoin moieties augments the number of the imide, amide, or amine groups groups on the polyamine's chain, which provides oxidizing properties to the resulting modified polyamine after halogenation. In one aspect, disclosed herein are polyamines with side chains modified to contain both (4-aminopyridine, APy) and 5-(4-hydroxybenzylidene)hydantoin (HBH) functionalities with enhanced content of the active bromine. Viricidal activity of the APy- and HBH-modified polyallylamine against human coronavirus (type 229E) was tested both in solution and on nylon-cotton fabric. The polymers are effective at inactivating the coronavirus, at both low concentrations and short exposure times.
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
C08F 226/06 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
25.
CONFORMABLE ULTRASOUND SCANNING AND IMAGING METHODS AND APPARATUS AND RELATED TECHNIQUES
Described herein is a patch, comprising: a honeycomb structure comprised of two or more cells, wherein each of the two or more cells include a window and one or more first attachment means; and a tracker comprised of a sensor and one or more second attachment means configured to mate with the first attachment means to arrange the sensor in the window, wherein the tracker is moved to different ones of the cells to traverse a path along the patch. In some embodiments, the two or more cells have a regular or irregular shape. In embodiments, there are two or more first attachment means and two or more second attachment means that mate to form a first position and a second position, wherein the tracker is configured move between the first position and the second position.
A multistage water treatment system that requires minimum energy and can be powered by low-grade energy sources, such as sunlight, is disclosed. The system may include multiple stages, where each stage comprises a hydrophobic membrane, a confined saline layer, and a condenser. Using a saline layer as the evaporator, as confined by a hydrophobic membrane, strong thermohaline convection is initiated to mitigate salt accumulation and enhance heat transfer. The multistage water treatment system is salt-resistant during continuous desalination of nearly saturated saline. Such a system enables water treatment by low-grade heat with water production exceeding the single-stage limit and ultrahigh salinity. This system is useful for water treatment, including seawater desalination, wastewater reclamation, residential water softening, and salt production from brine/seawater.
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (USA)
TRUSTEES OF DARTMOUTH COLLEGE (USA)
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (USA)
Inventor
Strey, Lilianne R.
Strey, Helmut
Granger, Richard M.
Edelman, Alan
Rackauckas, Christopher
Miller, Earl K.
Abstract
A system for generation and execution of brain circuit simulators includes at least one modular, hierarchical design comprising a plurality of micro-circuits. The system includes a neural control circuit simulator executing a simulation of the at least one design. The system includes a user interface comprising at least one interface element for manipulating output of the neural control circuit simulator. A method includes receiving, by a neural control circuit simulator, an identification of at least one modular, hierarchical design comprising a plurality of micro-circuits, the at least one modular, hierarchical design generated by a first user. The neural control circuit simulator executes a first simulation of the at least one design, using a first data set as simulation input. The neural control circuit simulator receives a second data set and executes a second simulation of the at least one modular, hierarchical design, using the second data set as simulation input.
FAN1FAN1 derived from the pre-mRNA in a target cell. The compositions and methods are particularly suited for treating, ameliorating, or delaying the onset of a trinucleotide repeat expansion disorder in a subject in need thereof.
Compositions and methods thereof for increasing endogenous FAN1 expression in a target cell are provided. Preferably, compositions include one or more splice switching antisense oligonucleotides targeting FAN1 exon 10-intron 10-exon 11 junction. The compositions are effective in increasing levels of functional FAN1 mRNA transcripts encoding FAN1 derived from the pre-mRNA in a target cell. The compositions and methods are particularly suited for treating, ameliorating, or delaying the onset of a trinucleotide repeat expansion disorder in a subject in need thereof.
Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under- utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.
Ingestible and/or implantable low power battery and signaling systems are generally provided. Advantageously, the systems and methods described herein may provide, in some embodiments, secure communication such that only authorized users and/or medical professionals can read sensor data and/or send valid commands to a system. Advantageously, the system and methods described herein may provide, in some embodiments, an energy-efficient security protocol to further improve the wireless communication (e.g., of an ingestible and/or implantable article). In some embodiments, the security protocol advantageously provides data encryption to protect sensor and command information and mutual authentication to prevent unauthorized access to both ingestible and external devices.
A61B 5/24 - Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.
C40B 50/06 - Biochemical methods, e.g. using enzymes or whole viable microorganisms
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12N 15/66 - General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligationUse of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
C40B 40/06 - Libraries containing nucleotides or polynucleotides, or derivatives thereof
C40B 40/08 - Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
G16B 50/30 - Data warehousingComputing architectures
Cyclic ruthenium benzylidene initiators useful for the controlled synthesis of functionalized cyclic macromolecules via ring-expansion metathesis polymerization.
C08F 132/04 - Homopolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having no condensed rings having one carbon-to-carbon double bond
C07F 15/00 - Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
A method for making a lithium salt film includes heating a substrate, spraying a mixture with a spray nozzle onto the substrate to form a precursor film, and annealing the precursor film to form the lithium salt film. The lithium salt film has a thickness of about 400 nm to about 100 pm. The spray mixture includes a first precursor comprising a lithium ion, a second precursor comprising an anion, and a solvent.
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
37.
READILY SOLUBLE AND THERMOSTABLE GLUCAGON FORMULATIONS AND DELIVERY FOR MINI-DOSING AND CLOSED -LOOP PROPHYLACTIC TREATMENT OF HYPOGLYCEMIA
Insulin therapy revolutionized the care of patients with diabetes, yet insulin-induced hypoglycemia remains a serious life-threatening complication of insulin therapy. Glucagon is a highly effective treatment for hypoglycemia; however, current dosage forms remain under-utilized due to poor patient compliance. High-density, readily soluble, and thermostable solid glucagon formulations applied with painless, application-specific microneedle-patches can treat hypoglycemia in type 1 diabetes patients who are awake or asleep. On-demand patches can prevent or treat mild hypoglycemia during the day, and enzyme-driven hypoglycemia-responsive patches can release glucagon autonomously during the night. These patches have excellent in vitro glucagon stability, loading, and release kinetics and can treat hypoglycemia in diabetic humans and animals. These delivery systems enable new modes of glucagon therapy, thereby expanding the clinical role of glucagon beyond the emergency setting.
Obtain, using at least one hardware processor, data characterizing a physical system governed by a physical conservation law. Apply, using the at least one hardware processor, contrastive learning to the data to automatically capture system invariants of the physical system. Employ, using the at least one hardware processor, a neural projection layer to guarantee that a corresponding dynamic machine learning model preserves the captured system invariants. Optionally, predict performance of the physical system using the corresponding dynamic machine learning model.
Disclosed are systems and methods for adjusting an infusion rate of a drug being delivered to a patient. The method includes extracting a fluid sample from the patient, isolating a drug filtrate by processing the fluid sample within a first time period, and analyzing the drug filtrate for a drug concentration using chromatography system, a mass spectrometry system, or both within a second time period. The method further includes comparing, using a control process, the drug concentration with a target concentration range, and adjusting the infusion rate of the drug to ensure the drug concentration is within the target concentration range.
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
40.
FLUORINATED SULFONAMIDE-BASED ELECTROLYTES FOR NON-LITHIUM BATTERIES THEREOF
Disclosed are compositions, electrolytes, electrochemical cells, and batteries comprising a halogenated sodium salt; a halogenated sulfonate; and a co-solvent.
A non-insulated superconducting magnet and related methods and systems are provided herein. In some aspects, the non-insulated superconducting magnet comprises at least one heating element configured to induce a quench of the non-insulated superconducting magnet by asymmetrically heating the non-insulated superconducting magnet. In some aspects, the non-insulated superconducting magnet comprises at least one cable comprising at least one heating element configured to induce quench of the non-insulated superconducting magnet by heating the non-insulated superconducting magnet. In some aspects, the non-insulated superconducting magnet comprises a first plate having at least one groove arranged in a plurality of turns, and a conductor disposed in the at least one groove, wherein a resistivity of the conductor varies along a length of the conductor.
A mobile physical telemedicine system includes a processing system and at least one robotic manipulator communicatively coupled to the processing system and configured to support and manipulate a body part of a subject. In some embodiments, the system includes a motion capture system communicatively coupled to the processing system and configured to capture a motion of the subject. In some embodiments, the system includes an adjustable therapy bench. In some embodiments, the system includes a base supporting the at least one robotic manipulator, the motion capture system, and the adjustable therapy bench. In some embodiments, the at least one robotic manipulator is configured to be controlled remotely by a clinical provider. In some embodiments, the at least one robotic manipulator is configured to be operated in an autonomous mode.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
43.
Chemical and Physical Sensing with a Reader and RFID Tags
A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial Near Field Communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
G08C 17/02 - Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
44.
ULTRA-HIGH RESOLUTION MAPPING OF 3D GENOME STRUCTURE USING REGION CAPTURE MICRO-C
A method for identifying nucleic acid regions which interact with each other in genomic DNA, the method including the steps of: (1) crosslinking genomic DNA (including chromatin) in cells; (2) digesting the crosslinked genomic DNA to obtain fragments; (3) fragment end labelling; (4) ligating nucleic acid fragments; (5) obtaining a purified DNA fraction of ligation products including mainly di-nucleosomes; (6) preparing a sequencing library from the DNA fraction of ligation products mainly di-nucleosomes; and (7) performing tiling region capture of a region of interest.
A method for identifying nucleic acid regions which interact with each other in genomic DNA, the method including the steps of: (1) crosslinking genomic DNA (including chromatin) in cells; (2) digesting the crosslinked genomic DNA to obtain fragments; (3) fragment end labelling; (4) ligating nucleic acid fragments; (5) obtaining a purified DNA fraction of ligation products including mainly di-nucleosomes; (6) preparing a sequencing library from the DNA fraction of ligation products mainly di-nucleosomes; and (7) performing tiling region capture of a region of interest.
Selection of processing steps/reagents in the disclosed method provides a significantly improved method when compared to prior methods such as Hi-C, Micro-C, Micro-Capture-C (MCC), and Tiled-Micro-Capture-C (TMCC) in terms of reduction in cost, significantly improved efficiency, with capture of genomic interactions including enhancer-promoter interactions such as microcompartments.
A multi-phase electrolyte film includes a first phase comprising a metal oxide, wherein the metal oxide is amorphous, crystalline, or a glass; and a second phase comprising a lithium salt having a decomposition temperature in air of greater than 200° C. or a lithium halide. The first phase is dispersed in the second phase and has an average particle size of 5 to 200 nanometers. Methods for the manufacture of the electrolyte film are also disclosed.
Provided herein are systems, devices, and methods for carbon capture and storage. A system for carbon capture and storage may comprise a chamber containing an aqueous solution, as well as a cathode and anode immersed in the aqueous solution. The system may further comprise a power supply connected to the cathode and the anode. The power supply may be configured to apply a voltage across the cathode and the anode, resulting in the electrochemical production of minerals as a solid precipitate.
Systems and methods disclose a practical implementation of optimal modulation (OM) for the Complex Additive White Gaussian Noise (CAWGN) channel. At the sender, we map from uniform distributions of data to non-uniform distributions of points in constellations by using a technique inspired by Huffman codes. We replace Gray codes with a bit mapping suited to our constellations, where different points may map to string of bits of different lengths. At the receiver, we perform distribution-aware detection. The differing lengths of bits for modulation points can used as a simple checking mechanism that, when combined with guessing random additive noise decoding (GRAND), yields bit-error-rate (BER) advantages.
The Research Foundation for the State University of New York (USA)
Inventor
Khaykovich, Boris
Zheng, Guiqiu
Sprouster, David
Abstract
A system for determining atomic structure and dynamics of salt under certain temperatures as a function of temperature above and below salt melting, contains a quartz tube containing a first end and a second end, and a graphite rod that is located within the quartz tube. The graphite rod contains a hollow center that extends from a top portion of the rod to a location prior to a bottom of the rod, wherein the bottom portion of the rod is enclosed. A sample of salt is located within the hollow center of the graphite rod. A filling material having the characteristics of not reacting to the graphite rod and not changing state with heating of the salt to a melting point of the salt, and wherein the filling material is positioned beneath the graphite rod between the second end of the quartz tube and the bottom of the graphite rod.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 1/44 - Sample treatment involving radiation, e.g. heat
49.
CONTROLLABLE TRANSFORMATION NETWORKS FOR RADIO FREQUENCY POWER CONVERSION
In one aspect, a system for transforming a radio frequency (RF) signal between a source and a load can include: a first port and a second port connected to different ones of the source and the load; a first filter connected to the first port; a second filter connected to the second port, at least one of the first and second filters operable to provide variable reactance using dynamic frequency tuning (DFT); a two-port switching network connected between the first filter and the second filter, the switching network comprising a plurality of switches; and a controller coupled to the switching network and to the source, the controller configured to operate the plurality of switches according to a switching pattern and to dynamically adjust a frequency of the RF signal to provide controllable impedance matching between the first port and the second port.
H02M 1/08 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters
H02M 5/293 - Conversion of AC power input into AC power output, e.g. for change of voltage, for change of frequency, for change of number of phases without intermediate conversion into DC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 7/5387 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
H03F 1/56 - Modifications of input or output impedances, not otherwise provided for
50.
Sequentially Stacked Multi-Stage Desalination System and Method
A sequentially stacked multi-stage desalination system includes a single pair of electrodes, including an anode and a cathode; at least one ion concentration polarization device; and at least one electrodialysis device coupled with the ion concentration polarization device and configured to receive liquid flow from the ion concentration polarization device. Each ion concentration device and electrodialysis device is positioned between the anode and the cathode.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
B01D 57/02 - Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. by electrophoresis
A system for rigid motion correction for magnetic resonance imaging (MRI) of a subject includes an input for receiving motion corrupted k-space data for the subject acquired using an MRI system, a motion parameter estimation module coupled to the input and configured to estimate motion parameters based on the motion corrupted k-space data, a motion correction neural network coupled to the input and the motion parameter estimation module and configured to generate motion corrected k-space data based on the motion corrupted k-space data and the estimated motion parameters, and a reconstruction module coupled to the motion correction neural network and configured to generate a motion corrected image from the motion corrected k-space data.
Described herein is an expander comprising a resonator having a resonator chamber and an input port, wherein the input port is configured to be coupled to a fluid source having a first pressure and a first temperature. In some embodiments, the expander comprises a first acoustic driver disposed at the input port of the resonator, wherein in response to pressure applied thereto, the first acoustic driver oscillates between an open state and a closed state to generate an acoustic wave within the resonator chamber. In some embodiments, the first acoustic driver comprises one of: a reed valve, a jet edge valve, a rotary valve, a high-speed computer controlled valve, or a solenoid valve. In some embodiments, in response to pressure applied thereto, the first acoustic driver oscillates between the open state and the closed state at a frequency that substantially matches a resonant frequency of the resonator chamber.
F03G 7/00 - Mechanical-power-producing mechanisms, not otherwise provided for or using energy sources not otherwise provided for
F25B 9/14 - Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
53.
REPLACING SYNTHETIC FERTILIZERS BY ENGINEERING CEREAL-ASSOCIATED NITROGEN-FIXING BACTERIA TO RELEASE UREA
Nitrogen is one of the primary nutrients essential to all forms of life. However, only a few plant species can live in a symbiotic relationship with nitrogen-fixing bacteria and nitrogen must first be converted to a form that plants can utilize. Accordingly, aspects of the present disclosure relate to providing nitrogen fixation to cereal plants using genetically engineered bacteria. In some embodiments, genetically engineered bacteria comprise engineered nucleic acids encoding one or more urea metabolism regulators and/or effect the activity of one or more urea metabolism regulators. In some embodiments, the genetically engineered bacterium release more extracellular urea compared to wildtype counterparts. In some embodiments, extracellular urea is ultimately broken down into ammonia and carbon dioxide which are subsequently used by a plant cell to produce amino acids and glucose, respectively.
Custom folded 3-dimensional plate lattices are modularly assembled to form structures with single and double curvature for use in structural engineering and robotics applications. The plate lattice structural corrugation uses a building block strategy and incorporates custom modified unit cells based on a Kirigami Expanded Miura pattern. This transformation involves expanding the top and bottom zig-zag crease lines into facets and orienting them in space. The structure of these lattices allows for the design of anisotropies in their flexural stiffness by alternating between the Maxwell criterion on bending-dominated and stretch dominated cells. These anisotropies can have value differences of up to 24 times with the same geometry, making them ideal for robotic morphing applications.
55.
BUILDING ENVELOPE REMOTE SENSING DRONE SYSTEM AND METHOD
Exemplary methods, systems, apparatus, and computer programs are disclosed for an unmanned aerial system (UAS) inspection system that includes an unmanned aerial system and analysis system for exterior building envelopes and energy performance evaluation and simulation. The UAS can autonomously and systematically collect data for a building's exterior using a payload comprising (i) nondestructive testing (NDT) sensors configured for imaging (visible, infrared, or more) the building and (ii) one or more multi-spectral sensors (LiDAR, ultrasound, radar, or more). The acquired sensor data are provided to an analysis system comprising computer vision (CV) and signal processing modules configured to analyze the acquired data to i) identify building objects (doors, windows, rooftop units, and others) ii) characterize envelope properties (components, heat resistivity, or others) and 3) identify initial thermal anomalies (thermal bridges, physical defects, or infiltration/exfiltration) in a processing pipeline.
G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
G01J 5/10 - Radiation pyrometry, e.g. infrared or optical thermometry using electric radiation detectors
G05D 1/689 - Pointing payloads towards fixed or moving targets
G05D 105/80 - Specific applications of the controlled vehicles for information gathering, e.g. for academic research
G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
An electrical joint includes a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions. Also described is a method of forming an electrical joint, comprising forming a conductive member having a first mounting region configured to connect to a first conductor and a second mounting region configured to connect to a second conductor, wherein the first conductor comprises a cable and a superconducting material within the conductive member and configured to conduct a current between the first and second mounting regions.
Additive manufacturing using bonding of voxels and related systems, devices, and articles are generally described. Certain embodiments are related to additive manufacturing with microscale resolution using solid-state kinetic bonding of microparticles or microfabricated thin-film voxels.
A high capacity current lead (10) comprises components that are electrically coupled using indium joints. The current lead includes a heat exchanger having a portion at room temperature (100) and a portion (200) within a vacuum cryostat. The room-temperature portion is temperature controlled against both overheating and over-cooling. The cryogenic portion (200) of the heat exchanger is electrically coupled to a coolant boiling chamber (300) using indium joints. The boiling chamber (300) has a lid and a base that may be electrically coupled using indium joints, or they may be brazed. The boiling chamber (300) is surrounded by a vacuum lid that may be electrically coupled to the base using indium joints, or brazed. The base is electrically coupled to a superconductor module (400) having high-temperature superconductor (HTS) tapes for conveying current to a device, such as a superconducting electromagnet.
Articles, compositions, and methods describing particles comprising micelles are generally described. In some embodiments, the micelles are configured to absorb pollutants from water and subsequently release the pollutants to a non-aqueous environment.
Multifunctional microelectronics fiber probes can be chronically implanted in tissue of awake-behaving animals for understanding brain-viscera communication. These fiber probes can be made using thermal drawing to make hundreds of meters of flexible fiber that incorporates features such as light sources, electrodes, thermal sensors, and microfluidic channels in a multilayered configuration. The fiber mechanics can be tuned for two distinct device layouts: (1) higher-modulus, flexible brain fibers for implantation into deep-brain; and (2) soft, compliant gut fibers for implantation into the small intestine. Brain fibers can modulate the deep-brain mesolimbic reward pathway. Gut fibers can perform peripheral optogenetic stimulation of vagal afferents from the intestine to stimulate brain reward neurons. Brain and gut fibers can be connected to a control module, for example, with a coiled, stretchable interconnect that is more flexible and stretches more than even soft gut fibers, in dual-organ (gut-brain) implantation.
Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.
Provided herein are oligonucleotides, cell-penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
63.
SYSTEMS, METHODS, COMPOSITIONS, AND DESIGNS FOR SYNTHESIS AND USE OF EXTREME-WATER-UPTAKE, LEAKAGE-FREE HYGROSCOPIC HYDROGELS
Systems, methods, compositions, and designs for synthesis and use of hygroscopic hydrogels are provided. Hygroscopic hydrogels can be used as scalable and low-cost sorbents for atmospheric water harvesting, dehumidification, passive cooling, and/or thermal energy storage. Sorbent materials can be loaded with salt by soaking the gel in an aqueous solution to form hygroscopic composites. The swelling dynamics of hydrogels in aqueous lithium-chloride solutions, its implications on hydrogel salt loading, as well as the resulting vapor uptake of the synthesized hydrogel-salt composites can be performed. Equilibrating the swelling process of the hydrogels can result in hydrogels with high water uptake and leak-free sorbents that significantly outperform comparative hydrogels.
Disclosed are systems and methods for dynamic occupational satiety stimulation. The system includes a device that includes at least one outer arm, a motor, and a controller that operates the motor to actuate the at least one outer arm. The controller operates the motor to pre-prandially extend the at least one outer arm away from a body of the device, and the controller further operates the motor to post-prandially contract the at least one outer arm.
65.
SYSTEMS, DEVICES, AND METHODS FOR ELECTRODIALYSIS-BASED HOME-SCALE DESALINATION
Systems, devices, and methods for electrodialysis-based home-scale water desalination are disclosed. The system can include an electrodialysis stack having one or more membranes that is in fluid communication with a pump and a valve manifold system for desalinating a feed stream pumped into the electrodialysis stack. Various circuit architectures for the manifold system are possible to obtain the desired recovery ratios that outperform conventional reverse osmosis symptoms. The pump, electrodialysis stack, and valve manifold system, and additional components of the electrodialysis system can be packaged within dimensions of a reverse osmosis cabinet, which can provide for in-home installation and use, while also minimizing points of failure.
The present invention provides polymer compositions for use in cosmetic nail polish compositions. More particularly, the present disclosure relates to the introduction of cleavable conomoner additives into an existing polymer composition to produce a chemically deconstructable composition. Methods and compositions for removing the nail polish composition are also disclosed.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
System and methods related to lyophilization of pharmaceutical products are disclosed. In some embodiments, vials of product are moved through a system using one or more movers which are electromagnetically levitated and moved through the system without making mechanical contact with each other or the system. Load lock chambers may allow a mover to enter from one process region's environment and then be brought to an environment condition of the next process region to allow materials to be passed through conditioning, nucleation, and/or vacuum drying regions prior to finally exit the system to an unloading zone. The movers may then be cleaned or reloaded with vials to begin the process again with a new load of vials.
A61K 9/19 - Particulate form, e.g. powders lyophilised
F26B 5/06 - Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
H02N 15/00 - Holding or levitation devices using magnetic attraction or repulsion, not otherwise provided for
The present disclosure provides methods of conducting phytoremediation of soil containing one or more contaminants comprising growing plants in soil treated with nanoparticles, wherein the plants uptake the nanoparticles.
B09C 1/10 - Reclamation of contaminated soil microbiologically or by using enzymes
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B09C 1/08 - Reclamation of contaminated soil chemically
69.
WINCHES FOR USE WITH INVERTING AND EVERTING ROBOTIC LIMBS
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventor
Barhydt, Kentaro
Osele, Obumneme Godson
Asada, Haruhiko, Harry
Abstract
Disclosed herein is a growing soft robot winch. The design may include a winch which comprises a drum and mandrel (e.g., a cylindrical shaft). The winch may be used to retain and retract a vine robot. The winch may use friction between adjacent portions of the vine robot wound onto the mandrel. One or more clamps configured to grasp the vine robot within a cavity formed in the mandrel may assist in retaining a distal end portion of the vine robot therein during operation. The mandrel may form part of a winch such that the vine robot wound thereon may be held on primarily by friction to apply large tensile loads to the attached vine robot.
F15B 15/10 - Fluid-actuated devices for displacing a member from one position to anotherGearing associated therewith characterised by the construction of the motor unit the motor being of diaphragm type
B25J 11/00 - Manipulators not otherwise provided for
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
B25J 21/00 - Chambers provided with manipulation devices
70.
Method and System for Data-Hiding Within Audio Transmissions
A method for hiding data within cover audio uses a set of sample codebook waveforms that are each assigned a unique representative digit value. A hidden data sequence representing the data is formed from the waveforms by concatenation of the waveforms assigned to the digit values of the data. The sequence is superimposed upon segments of the cover audio at a fractional amplitude. After transmission, the received signal is decompressed if necessary, the hidden data sequence is recovered from the cover audio, and the data is recovered from the hidden data sequence. This may be done by recovering the locations of the codebook waveforms and interpolating the time markers of the locations. The recovered data may be cleaned up by using estimated distances between successive cross-correlations to discard extraneous correlation peaks and sequence recurrence to probabilistically delete overlapping correlation peaks.
G10L 19/018 - Audio watermarking, i.e. embedding inaudible data in the audio signal
G10L 19/00 - Speech or audio signal analysis-synthesis techniques for redundancy reduction, e.g. in vocodersCoding or decoding of speech or audio signals, using source filter models or psychoacoustic analysis
Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of one or more n-mer inserts, that can include one or more RGD motifs, and/or one or more P-motifs. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.
The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups, e.g., —OH and/or —CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers may be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.
C08F 232/08 - Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings
C08F 234/02 - Copolymers of cyclic compounds having no unsaturated aliphatic radicals in a side chain and having one or more carbon-to-carbon double bonds in a heterocyclic ring in a ring containing oxygen
73.
RADIATIVELY RECUPERATED REACTOR SYSTEM AND RELATED METHODS, SUCH AS CHEMICAL LOOPING PROCESSES
What is disclosed relates to a novel reactor system design for chemical looping solar fuel production processes incorporating temperature swing between two or more zones, wherein two or more individual reactors are employed, and heat is recuperated between the reactors by means including radiative heat exchange. Each individual reactor comprising the overall system is isolated from other reactors and the external environment for gas exchange purposes, so that the inflow and outflow of chemical species from individual reactors can be controlled. Individual reactors are arranged in the form of a moving train, and heat exchange between a pair of reactors is facilitated by radiative exchange. External heat addition and removal between the system and its environment may be achieved by means including radiative heat exchange with the hot source and convective exchange with the cold source. This may include, in a particular embodiment, the use of solar irradiation. The disclosure also includes procedures for operating such a system.
Systems and methods for providing a configurable handle for assisting a user to perform an activity arc disclosed. A device may include a mobile base, a robotic arm attached to and supported by the mobile base, and a handle attached to the robotic arm. The handle may be configured to be grasped by and support a user during the activity and the robotic arm may be configured to position the handle in a desired pose relative to the user during the activity. The device may be calibrated involving one or more cameras configured to image the user.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
76.
TRACKING THE LEVEL OF ANESTHESIA-MEDIATED UNCONSCIOUSNESS
Systems and methods for controlling anesthetic-mediated unconsciousness in a patient are disclosed. An electroencephalogram (EEG) of a patient under a GABAergic-anesthetic may be recorded using EEG electrodes. Unconsciousness maintained by GABAergic anesthetics, such as propofol, propanidid, and/or sevoflurane, is characterized by slow-delta oscillations (0.3-4 Hz) and alpha oscillations (8-14 Hz) that may be viewed in an electroencephalogram (EEG). An alpha modulation index and a slow modulation index may be computed to characterize the level of unconsciousness of the patient and set a desired level of unconsciousness. The system may automatically or manually adjust the infusion rate of the anesthetic to achieve the desired level of unconsciousness.
A method of polynucleotide synthesis includes a series of enzymatic reactions for restriction, ligation, and amplification using a machine and system that provide efficient droplet-based reactions. The method enables hierarchical assembly with minimal handling in order to address challenges associated with traditional polynucleotide synthesis methods, such as high cost, limited throughput, long synthesis times, and limited ability to synthesize long sequences.
An antenna comprises first and second substrates with one or more spacers disposed therebetween so as to provide a substantially uniform an air gap between the substrates. Disposed on the first and second substrates are one or more antenna elements and disposed on at least one of the substrates is a feed circuit.
The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters/signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.
A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A61M 60/422 - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
A61M 60/531 - Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
A61M 60/554 - Regulation using real-time blood pump operational parameter data, e.g. motor current of blood pressure
Embodiments utilize a method of making a mold (108a) of additive manufacturing material for use in producing a structural element for a structure. The mold (108a) includes an interior surface (502) having a geometry defined by the additive manufacturing material configured to constrain a composition of matter to be disposed within the geometry of the interior surface at least until the composition of matter sufficiently stabilizes with a shape, based on the geometry, toward becoming the structural element. The mold also includes an exterior surface (503) having a geometry defined by the additive manufacturing material, the geometry being a function of: (i) hydrostatic pressure expected to be exhibited as a combination of at least the composition of matter as constrained by the interior surface, and (ii) properties of the additive manufacturing material between the interior and exterior surfaces.
Methods for designing a prosthetic feet for use by above-knee amputees, and the resulting prosthetic foot designs, are disclosed. The prosthetic foot can be optimized to best replicate hip movement of an able-bodied user for an above-knee amputee that inherently lacks early and mid-stance knee flexion. The replication can be determined by minimizing what is referred to as a hip trajectory error. The resulting prosthetic foot design includes a keel, an elongated forefoot section attached to the keel at an attachment point, the forefoot section having a toe portion anterior to the attachment point, and a heel attached to the forefoot section and positioned posterior to the attachment point. The keel, the forefoot section, and the heel are configured to provide both shock absorption and replication of hip motion of a comparable able-bodied user despite a lack of early-stance knee flexion and mid-stance knee flexion to an above-knee amputee.
84.
REPROGRAMMABLE FANZOR POLYNUCLEOTIDES AND USES THEREOF
Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel Fanzor polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are described.
85.
METHODS, APPARATUS, COMPOSITIONS OF MATTER, AND ARTICLES OF MANUFACTURE RELATED TO ADDITIVE MANUFACTURING OF POLYMERS
Systems, methods, and compositions for using Interfacial Photopolymerization (IPP) for high-resolution digital processing of polymers are disclosed. In IPP, a polymer film can be formed at an interface between two liquids, each containing a species involved in a polymerization reaction. The two liquids can include a photoinitiator and a monomer that are immiscible and/or reactive such that the film can form at the interface. The polymerization reaction can be controlled by a LED light source, which is focused at a reaction zone located at or near the liquid-liquid interface. The resulting polymer results in a high-resolution, high-throughput AM of thermoplastic polymers that enables on-demand production of objects that exhibit exceptional dimensional quality, mechanical properties, and recyclability characteristics.
B29C 64/124 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
Hybrid evaporative and radiative cooling panel systems having increased cooling efficiency while minimizing water consumption are provided. The disclosed hybrid systems include a cooling panel that enables the improved cooling and water consumption via a reflector layer which reflects solar radiation, an evaporative and infrared-emitting layer that is solar-transparent and water-rich, and an insulation layer that is vapor-permeable. infrared-transparent. and solar-reflecting. The cooling panel is configured to be in fluid communication with a heat exchanger. The cooling panel is further configured to cool a heat transfer fluid by way of both evaporative cooling and radiative cooling. The cooling panel is also configured such that the heat transfer fluid passes at least one of through or across the cooling panel and flows to the heat exchanger. Various configurations of such panels and panel systems. and methods of implementing the principles associated with the same. are also disclosed.
Described are concepts, systems, structures and techniques for metal filling an open channel (12) in a baseplate (19). In embodiments, metal filling of an open baseplate channel is achieved using vacuum pressure impregnation (VPI). In embodiments, a compression plate (14a) is disposed over an open baseplate channel (12) to be filled with a molten metal. In embodiments, gaskets (97) are disposed between the compression plate (14a) and a surface of the baseplate (10) proximate the baseplate channel (12). In embodiments, a channel cap (26) is disposed over the open channel. In embodiments, the channel cap (26) has a solder flow channel (29, 32) provided in a surface thereof. In the embodiments, the solder flow channel (29, 32) has a meandering shape. In embodiments, a solder flow channel (29, 32′) is provided in the compression plate (14a) and/or the baseplate (10). The concepts, systems, structures and techniques described herein are suitable for use in the fabrication of a no-insulation, no-twist (NINT) high temperature superconducting (HTS) magnet.
H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
H01F 41/04 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets for manufacturing coils
Meta-optic systems are described that include multi-function metasurfaces formed from a plurality of meta-atoms. A multi-function metasurface can exhibit two or more different optical functions for two or more different states of light incident on the metasurface. Different states of light include different polarizations, different wavelengths, and different angles of incidence. Different optical functions include distance sensing, converging, diverging, image formation, and patterned light formation. The multi-function metasurface can selectively impart different phase profiles to an incident beam depending on the incident beam's state of light.
G02B 1/00 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements
G02F 1/01 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour
H04N 13/239 - Image signal generators using stereoscopic image cameras using two 2D image sensors having a relative position equal to or related to the interocular distance
H04N 13/254 - Image signal generators using stereoscopic image cameras in combination with electromagnetic radiation sources for illuminating objects
H04N 23/958 - Computational photography systems, e.g. light-field imaging systems for extended depth of field imaging
89.
EVOLVING RANDOM HETEROPOLYMERS TOWARDS CATALYTICALLY ACTIVE MATERIALS
The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.
C07C 29/14 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of a —CHO group
B01J 31/06 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing polymers
The present disclosure provides new prime editor guide RNAs for prime editing, constructs for prime editing, and methods for using same. In addition, the present disclosure provides compositions and methods for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis (e.g., insertion or deletion). The nucleotide change can include a single-nucleotide change (e.g., any transition or any transversion), an insertion of one or more nucleotides, or a deletion of one or more nucleotides. More in particular, the disclosure provides fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a prime editor RNA (PEgRNA). The prime editor guide RNA comprises an extension arm that provides a DNA synthesis template sequence which encodes a single strand DNA flap, which is homologous to an endogenous DNA sequence, but which contains the desired one or more nucleotide changes and which, following synthesis by the polymerase (e.g., reverse transcriptase), becomes incorporated into the target DNA molecule.
A system comprising a processor and a non-transitory computer-readable medium communicatively coupled to the processor is provided. The medium stores instructions configured to cause the processor to perform operations including receiving, from a user, a search request comprising one or more keywords related to a desired item, determining that the user is a participant in a closed-loop recycling program based on a user setting, identifying, based on the determination and the keywords, one or more item results, at least one qualifying result of the one or more item results having a packaging meeting a predetermined level of recyclability, and providing to the user in a prioritized manner, the at least one qualifying result.
Disclosed herein are polymer networks that include di- and tetra-functional cyclobutane mechanophores, where the mechanophores are incorporated into end-linked polymer networks. Methods of preparing such polymers and of using such polymers are also disclosed herein.
Described in several exemplary embodiments are compositions including a targeting moiety effective to target a central nervous system cell and formulations thereof. In certain embodiments, the targeting moiety is composed of one or more n-mer inserts, that can include one or more RGD motifs, and/or one or more P-motifs. Also described in certain example embodiments are vector systems configured to generate polypeptides containing the one or more targeting moieties. Also described herein are methods of generating a targeting moiety effective to target a central nervous system cell and using the compositions containing the targeting moieties described herein, such as to deliver a cargo to a subject and/or treat a central nervous system disease, disorder, or system thereof.
Recent advances in the understanding of two CRISPR-Cas systems, namely, Type VI (Cas13a-d) and Type III (Type III-A-B), have shown both of them to have the ability to efficiently target RNA. Provided herein are compositions and methods for trans-splicing precursor mRNA using a catalytically-inactive Cas protein (dCas) and a trans-splicing construct comprising a guide RNA, an intron, a splice acceptor, donor RNA, and a poly A tail. The dCas is capable of forming a complex with the guide RNA and directing sequence-specific binding of the complex to a target precursor mRNA for genetic modification and any polypeptides derived thereof. The technology has important potential therapeutic applications such as correcting genetic mutations through exon replacement, insertion of transgenes, and increasing gene expression, and in non-therapeutic applications such as cell- and tissue-specific diagnostics.
Methods of purifying full capsids of recombinant adeno-associated virus vectors (rAAVs) from a solution containing a mixture of full and empty capsids are described. Typically, methods use crystallization reagents and conditions that preferentially crystalize full rAAV capsids over empty rAAV capsids. Specifically, crystallization reagents and conditions that preferentially crystalize full rAAV5 or rAAV8 capsids over their corresponding empty rAAV capsids are described. The resulting crystals containing mostly or exclusively full rAAV capsids are particularly suited for use in gene therapy. Methods of storing and reconstituting the crystals of full rAAV capsids in preparation for administering to a subject in need thereof are also provided.
Compositions are provided that include a lipid nanoparticle (LNP);a self-replicating RNA encoding a gene of interest loaded within the LNP; and an inhibitory nucleic acid, such as a small interfering RNA (siRNA) targeting IFN-α/β receptor l(Ifharl) gene loaded within the LNP, and use of the compositions for generating an immune response.
Computer program products, computer systems, and computer-implemented methods for making and using computational models for prediction of molecular recognition (MR) between a nanomaterial (NM) MR binder and an analyte. Methods for making a computational model involve selecting a candidate NM MR binder and conducting a physical test to determine whether MR occurs between the candidate NM MR binder and an analyte, and correlating features of the candidate NM MR binder with an experimental result obtained from the physical test to produce predictive information for the computational model. Methods for using the computational model involve receiving features of an untested candidate NM MR binder and analyzing the features to produce a prediction score that represents an expected experimental result of a physical test of the untested candidate MR binder and associating the prediction score with the untested candidate MR binder.
G16C 20/10 - Analysis or design of chemical reactions, syntheses or processes
G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
Board of Regents, The University of Texas System (USA)
Imperial College Innovations Limited (United Kingdom)
Massachusetts Institute of Technology (USA)
Inventor
Hodes, Marc
Bahadur, Vaibhav
Crowdy, Darren G.
Papageorgiou, Demetrios T.
Hatton, Trevor Alan
Abstract
A carbon-capture device and related processes are disclosed. The devices include substrate surfaces having a textured surfaces and a liquid sorbent contacting the texture surface in either a Cassie-Baxter state, in the case of a texture omniphobic surface or a plurality of re-entrant features or a Wenzel state, in the case of a textured omniphilic surface. The liquid sorbent reversibly captures a chemical species, which can usefully be carbon dioxide. This reversible capture can be exploited to capture and sequester carbon or other chemical species of interest.
B32B 15/08 - Layered products essentially comprising metal comprising metal as the main or only constituent of a layer, next to another layer of a specific substance of synthetic resin
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B32B 3/26 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids
B32B 27/20 - Layered products essentially comprising synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
Aspects of the disclosure relate to non-naturally occurring constructs for the activation of Shank3 gene expression, AAV vectors comprising the constructs, and gene therapy methods.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A61P 25/00 - Drugs for disorders of the nervous system
A method for operation of AOFP circuits includes accepting data arriving at any phase of a clock cycle, synchronizing the data to a known phase of a subsequent clock cycle, and providing the synchronized data to an AQFP circuit during the known phase of the subsequent clock cycle. The accepting and synchronizing of the data may be performed by a phase synchronizer and/or by a token-passing circuit. An asynchronous AOFP device includes at least one AQFP circuit and an activation phase synchronizer and/or token-passing circuit. The phase synchronizer may comprise a multiplexed array of QFP Buffers that samples each input phase of the clock cycle through a weak constant zero cell and outputs the logical OR of all input clock phases, propagating an input signal on any activation phase to a first phase output of the next activation cycle. The data may be passed from the phase synchronizer to a token-passing circuit, which passes the accepted and synchronized data to the AQFP during the known phase of the subsequent clock cycle. The token-passing circuit may comprise at least one driving QFP circuit that is triggered by the presence of the accepted data and activates at least one variable activation QFP circuit to store the accepted data in a buffer or propagate it to the AQFP circuit during the known phase of the subsequent clock cycle.