Abstract

The disclosure relates to methods and kits for detecting, quantifying, or both, phosphorylated tau (p-tau) in a biological sample. The disclosure further provides methods for detecting brain-associated tau polypeptide, a brain injury or a neurodegenerative disease in a subject, determining the eligibility of individuals for participation in clinical trials for brain injury and/or neurodegenerative disease treatments, distinguishing between individuals with brain injury and/or neurodegenerative disease and without brain injury and/or neurodegenerative disease, and monitoring response to treatment of the same.

IPC Classes  ?

• G01N 33/541 - Double or second antibody
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates to kits and components thereof used in the conduct of solid-phase binding assays.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Devices and methods for determining whether a contact of a liquid dispenser with a liquid based on sound and/or for determining a liquid volume in the liquid dispenser are provided. According to an embodiment, the liquid dispenser includes a sound generator and an acoustic sensor, and at least one of the sound generator or the acoustic sensor is disposed within the dispense chamber portion. According to an embodiment, the liquid dispenser includes a sound generator and an acoustic sensor, and further includes one or more side conduits, where at least one of the sound generator or the acoustic sensor is disposed within a cavity of a respective one of the one or more side conduits, wherein the cavity and a connector of each of the one or more side conduits are free from resonance within a frequency range of the sound sensed by the acoustic sensor.

IPC Classes  ?

• G01N 1/14 - Suction devices, e.g. pumpsEjector devices
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G01V 1/02 - Generating seismic energy
• G01V 1/16 - Receiving elements for seismic signalsArrangements or adaptations of receiving elements

Goods & Services

reagents and biological reagents for scientific or medical research use; chemicals for use in the fields of science, medicine and laboratory research reagents and biological reagents, namely, clinical medical reagents automated assay systems comprising analyzers and other scientific equipment and apparatuses used for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples; biological, biochemical and chemical analyzers for performing assays, selection, testing, imaging and diagnostics of biological, biochemical and chemical samples; scientific equipment and apparatus for use in the performance of assays, selection, testing, imaging and diagnostics of biological, biochemical and chemical samples; computer hardware and peripheral devices used to control and operate portable electronic and scientific instruments in a laboratory setting; Wearable cameras; wearable activity trackers; wearable computers in the nature of smartwatches; wearable computers in the nature of smart glasses; eyewear; sunglasses; recorded software for controlling the operation of biochemical, biological and chemical analyzers; downloadable computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; downloadable software for controlling the operation of biochemical, biological and chemical analyzers; downloadable software for designing and executing scientific, biological, biochemical and chemical testing and experiments; recorded computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; recorded software for designing and executing scientific, biological, biochemical and chemical testing and experiments; downloadable and recorded computer software for data management and analysis of biological assays, pharmaceutical screenings, and biological and pharmaceutical testing; downloadable and recorded computer software for data management and analysis of imaging and biological diagnostics; downloadable and recorded computer software allowing administrators and supervisors to assign roles and grant permission to designated users to utilize certain data and information, and perform assigned tasks, associated with scientific, biological, biochemical and chemical research and analysis medical devices; medical instruments clothing; footwear; hats; caps toys; games custom manufacture of reagents, and chemicals and chemical products for use in the fields of science, medicine and laboratory research for others educational services; entertainment services scientific research and development; research and development in the fields of biological reagents and chemicals for use in the fields of science, medicine and laboratory research; providing a website featuring temporary use of non-downloadable software for performing the assignment of roles, granting of permissions, and designating users to utilize certain data and information, and perform assigned tasks; providing a website featuring temporary use of non-downloadable software used for allowing administrators and supervisors to assign roles and grant permission to designated users to utilize certain data and information, and perform assigned tasks, associated with scientific, biological, biochemical and chemical research and analysis; providing a website featuring temporary use of non-downloadable software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; providing a website featuring temporary use of non-downloadable computer software for data management and analysis of biological assays, pharmaceutical screenings, and biological and pharmaceutical testing; providing a website featuring temporary use of non-downloadable computer software for data management and analysis of imaging and biological diagnostics, controlling the operation of biochemical, biological and chemical analyzers, and designing and executing scientific, biological, biochemical and chemical testing and experiments

Abstract

The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention also provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention is directed to methods for improving assay specificity and performance in binding assays.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C12Q 1/6832 - Enhancement of hybridisation reaction
• C12Q 1/6837 - Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
• C12Q 1/6844 - Nucleic acid amplification reactions

Abstract

The invention relates to novel compositions comprising an electrochemiluminescence (ECL) co-reactant. In embodiments, the composition further comprises an ionic component, a surfactant, or combination thereof. In embodiments, the ECL co-reactant is triethanolamine (TEA), tert-butyldiethanolamine (tBDEA), methyldiethanolamine (MDEA), 3-[Bis-(2-hydroxy-ethyl)-amino]-propane-1-sulfonic acid (DEA-PS), or a combination thereof. Methods of using the compositions and kits comprising the compositions are also provided herein.

IPC Classes  ?

• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The disclosure relates to method and kits for highly specific detection and quantification of extracellular vesicles (EVs) by targeting at least two EV surface markers using binding reagents. The binding reagents contain hybridisation sequences and primer binding regions, the hybridisation sequences are ligated and amplified using primers. The disclosure further relates to methods and kits for isolating EVs using capture entities, splint entities and staple entities wherein the capture entity comprises a labile linkage.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6855 - Ligating adaptors
• C12Q 1/6869 - Methods for sequencing
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes

Abstract

The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C12Q 1/6823 - Release of bound markers
• C12Q 1/6832 - Enhancement of hybridisation reaction
• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor

Abstract

The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• C12Q 1/6813 - Hybridisation assays
• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• G01N 33/542 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1β, IL-2, IL-6, IL-10, IL-22, IP-10, TNFα, TSLP, NFL, and/or NFH.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Goods & Services

Biological assays for research purposes; kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use Reagents for scientific and medical research use; Diagnostic reagents for medicinal and veterinary use; Biological medical and veterinary assays and reagents for medical and diagnostic testing purposes; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use Research and development in the field of assays for the detection and measurement of molecules, proteins, and peptides in biological samples and environmental samples; sample testing services in the fields of scientific and clinical research; laboratory biomarker analysis services and related data analysis

Abstract

A sample collection device having a sample container, a solid phase binding material, and a container sealing component is presented. The sample container may have a housing that forms an opening for receiving a sample, and that encloses a space for holding the sample. The solid phase binding material may be disposed within the space enclosed by the housing of the sample container and may be adapted, when the sample contains an analyte, to bind specifically to the analyte. The container sealing component may be removably attachable to the sample container at the opening thereof, and may be adapted, when attached to the sample container, to form a seal around the opening of the sample container.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 1/40 - Concentrating samples
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• C12N 5/0781 - B cellsProgenitors thereof
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for medical and/or veterinary use Research and development in the fields of biological and chemical assays, and their uses in selection, screening, testing, imaging and diagnostics; providing biological and biochemical sample testing for others through the performance of assays in the fields of scientific and clinical research

Abstract

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B67B 7/00 - Hand- or power-operated devices for opening closed containers
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/04 - Details of the conveyor system
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The disclosure relates to methods and kits for detecting tau, e.g., tau that is phosphorylated at amino acid position T181 (pTau181), tau that is phosphorylated at amino acid position T217 (pTau217), and/or total tau. The disclosure further provides methods for distinguishing between individuals whose cognitive condition will remain stable and whose cognitive condition will decline during their lifetime. The disclosure also provides methods for determining the eligibility of individuals for participation in clinical trials for Alzheimer's disease treatments. Also provided are methods for distinguishing between individuals with Alzheimer's disease and non-Alzheimer's dementia, and for monitoring response to treatment for Alzheimer's disease.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/6844 - Nucleic acid amplification reactions
• G01N 21/76 - ChemiluminescenceBioluminescence

Abstract

Described herein is a method for detecting an oligonucleotide in a sample, and in particular, to a method for detecting sense and antisense strands of an oligonucleotide duplex in a sample.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

Described herein is a method for detecting an oligonucleotide in a sample, and in particular, to a method for detecting sense and antisense strands of an oligonucleotide duplex in a sample.

IPC Classes  ?

• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• C12Q 1/44 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase involving esterase
• C12Q 1/6818 - Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Abstract

The invention relates to methods and kits for detecting a virus, e.g., a respiratory virus such as a coronavirus, in a biological sample. The invention also relates to methods and kits for detecting and/or quantifying biomarkers, e.g., antibody biomarkers against a viral antigen; inflammatory and/or tissue damage response biomarkers; and/or extracellular vesicles in response to a viral infection.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Goods & Services

Reagents for scientific use; Biological assays for research purposes; biological kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific andresearch use; biological kits comprising arrays for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific and research use; biological kits comprising reagents and arrays for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific and research use Reagents for medical use; reagents for veterinary use; medical and biological diagnostic assays for testing biological samples for medical or veterinary use; biological kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for medical use; biological kits comprising arrays for the detection of biological analytes and for use in the fields of biological and diagnostic testing for medical use; biological kits comprising reagents and arrays for the detection of biological analytes and for use in the fields of biological and diagnostic testing for medical use Multi-well plates, namely, plates having multi-well arrays, that can be used in chemical or biological analysis for scientific, laboratory or medical research use; biological, biochemical and chemical analyzers for performing assays, selection, testing, and imaging of biological, biochemical, chemical, and environmental samples.

Goods & Services

Biological assays for research purposes; kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; Reagents for scientific and medical research use Diagnostic reagents for medicinal and veterinary use; Biological medical and veterinary assays and reagents for medical and diagnostic testing purposes; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use Research and development in the field of assays for the detection and measurement of molecules, proteins, and peptides in biological samples and environmental samples; sample testing services in the fields of scientific and clinical research; laboratory biomarker analysis services and related data analysis

Goods & Services

Research and development in the field of biology, chemistry, biochemistry, microbiology, and genetics; scientific research and development.

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use. Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use. Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use.

Goods & Services

biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use biological, biochemical and chemical analyzers for performing assays, selection, testing, imaging and diagnostics of biological, biochemical and chemical samples; multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; cartridges that can be used in chemical or biological analysis for scientific, laboratory or medical research use; laboratory apparatus, namely, lateral flow test assays, strips, and kits used in chemical or biological analysis for scientific, laboratory or medical research use; recorded software for the computing, sensing, recording, and transmitting of data and information in the fields of scientific research and development, research and development in the fields of biological reagents and chemicals in the fields of science, medicine and laboratory research, research and development in the field of assays for the detection and measurement of biological and chemical analytes, biological, chemical, biochemical, environmental sample testing and diagnostics for others in the fields of scientific and clinical research, and monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; downloadable software for the computing, sensing, recording, and transmitting of data and information in the fields of scientific research and development, research and development in the fields of biological reagents and chemicals in the fields of science, medicine and laboratory research, research and development in the field of assays for the detection and measurement of biological and chemical analytes, biological, chemical, biochemical, environmental sample testing and diagnostics for others in the fields of scientific and clinical research, and monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; scientific apparatuses for the computing, sensing, recording, and transmitting of data and information in the fields of scientific research and development, research and development in the fields of biological reagents and chemicals in the fields of science, medicine and laboratory research, research and development in the field of assays for the detection and measurement of biological and chemical analytes, biological, chemical, biochemical, environmental sample testing and diagnostics for others in the fields of scientific and clinical research, and monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; wearable cameras; wearable activity trackers; wearable computers in the nature of smartwatches; wearable computers in the nature of smartglasses; eyewear; sunglasses; recorded software for controlling the operation of biochemical, biological and chemical analyzers; downloadable computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; downloadable software for controlling the operation of biochemical, biological and chemical analyzers; downloadable software for designing and executing scientific, biological, biochemical and chemical testing and experiments; recorded computer software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; recorded software for designing and executing scientific, biological, biochemical and chemical testing and experiments; downloadable and recorded computer software for data management and analysis of biological assays, pharmaceutical screenings, and biological and pharmaceutical testing; downloadable and recorded computer software for data management and analysis of imaging and biological diagnostics; downloadable and recorded computer software allowing administrators and supervisors to assign roles and grant permission to designated users to utilize certain data and information, and perform assigned tasks, associated with scientific, biological, biochemical and chemical research and analysis medical devices; medical instruments clothing; footwear; hats; caps toys; games educational services; entertainment services providing a website featuring temporary use of non-downloadable software used for the computing, sensing, recording, and transmitting of data and information; Research and development in the field of assays for the detection and measurement of biological and chemical analytes in samples taken from cells, organisms, and the environment, and research and development regarding the selection, screening, testing, imaging and diagnostics of said samples; scientific research and development; providing biological, chemical, biochemical, and environmental sample testing and diagnostics for others through the performance of assays in the fields of scientific and clinical research; monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; scientific services, namely, epidemiological testing for scientific research, clinical research, and medical research purposes; scientific research consulting in the field of assays for the detection and measurement of analytes in biological, chemical, biochemical, and environmental samples, and scientific research consulting regarding the selection, screening, testing, imaging and diagnostics of said samples; providing a website featuring temporary use of non-downloadable software for performing the assignment of roles, granting of permissions, and designating users to utilize certain data and information, and perform assigned tasks; providing a website featuring temporary use of non-downloadable software used for allowing administrators and supervisors to assign roles and grant permission to designated users to utilize certain data and information, and perform assigned tasks, associated with scientific, biological, biochemical and chemical research and analysis; providing a website featuring temporary use of non-downloadable software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information; providing a website featuring temporary use of non-downloadable computer software for data management and analysis of biological assays, pharmaceutical screenings, and biological and pharmaceutical testing; providing a website featuring temporary use of non-downloadable computer software for data management and analysis of imaging and biological diagnostics, controlling the operation of biochemical, biological and chemical analyzers, and designing and executing scientific, biological, biochemical and chemical testing and experiments

Goods & Services

Automated assay systems comprising analyzers and other scientific equipment and apparatuses used for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples. Providing biological, chemical, biochemical, and environmental sample testing and diagnostics for others through the performance of assays in the fields of scientific and clinical research; monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; scientific services, namely, epidemiological testing for scientific research, clinical research, and medical research purposes; scientific research consulting in the field of assays for the detection and measurement of analytes in biological, chemical, biochemical, and environmental samples, and scientific research consulting regarding the selection, screening, testing, imaging and diagnostics of said samples.

Abstract

Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

IPC Classes  ?

• G02B 7/36 - Systems for automatic generation of focusing signals using image sharpness techniques
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/64 - FluorescencePhosphorescence
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Goods & Services

(1) Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use. (2) Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use. (3) Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use.

Goods & Services

Biological, biochemical and chemical electrochemiluminescence-based analyzers for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples; all of the forgoing excluding mass spectrometers, mass selective detectors, detectors for use with chromatographs, and goods or services for use with mass spectrometers, mass selective detectors and detectors for use with chromatographs (term considered linguistically incorrect by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations).

Goods & Services

(1) Research and development in the field of biology, chemistry, biochemistry, microbiology, and genetics; scientific research and development.

Goods & Services

biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; Biological assays for research purposes Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; Cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use Research and development in the fields of assays, selection, screening, testing, imaging and diagnostics using electrochemiluminescence; providing biological and biochemical sample testing for others through the performance of assays in the fields of scientific and clinical research; scientific research and development

Abstract

Systems and methods for improving assay results obtained by silicon photomultiplier devices are provided. Systems may include assay devices including silicon photomultiplier devices and computing systems. Systems may further include processing components and storage units configured for receiving silicon photomultiplier device input and output information and for determining silicon photomultiplier device temperatures.

IPC Classes  ?

• G01J 1/44 - Electric circuits
• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/76 - ChemiluminescenceBioluminescence

Goods & Services

(1) Automated assay systems comprising analyzers and other scientific equipment and apparatuses used for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples. (1) Providing biological, chemical, biochemical, and environmental sample testing and diagnostics for others through the performance of assays in the fields of scientific and clinical research; monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; scientific services, namely, epidemiological testing for scientific research, clinical research, and medical research purposes; scientific research consulting in the field of assays for the detection and measurement of analytes in biological, chemical, biochemical, and environmental samples, and scientific research consulting regarding the selection, screening, testing, imaging and diagnostics of said samples.

Abstract

The present disclosure relates to an automated assay system adapted to receive consumables in the conduct of an assay. The assay system includes at least one of a loading cart, a door support system, a waste storage unit, and a robotic subsystem. The loading cart is configured to organize and transport consumables necessary for the performance of the assay system. The door support system is configured to maintain stability of doors of the automated assay system. The waste storage unit is configured to provide convenient disposal of consumables associated with the automated assay system. The robotic subsystem is configured to transport consumables within the automated assay system.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• B65D 43/02 - Removable lids or covers
• B65D 43/26 - Mechanisms for opening or closing, e.g. pedal- operated
• B65D 51/24 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes

Abstract

We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In emodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE).

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence

Abstract

The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention also provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Devices and methods for a microplate lid configured to cover a microwell assay plate are provided. A microplate lid includes a lid panel surrounded by a lid frame. Sidewalls extend downwardly from lid frame. The microplate lid includes various features to improve performance, including features to improve stickability, reduce warping, reduce sample contamination, reduce wear, reduce sample evaporation, facilitate robotic handling, and provide other benefits.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Goods & Services

Biological assays for research purposes; biological kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific, and research use Reagents for scientific and medical research use; Diagnostic reagents for medicinal and veterinary use; Biological medical and veterinary assays and reagents for medical and diagnostic testing purposes; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use Laboratory consumable, namely, plates having multiple wells that can be used in chemical or biological analysis for scientific, laboratory, or medical research use; laboratory consumable, namely, plates having multi-well arrays that can be used in chemical or biological analysis for scientific, laboratory, or medical research use Research and development in the field of assays for the detection and measurement of molecules, proteins, and peptides in biological samples and environmental samples; Providing biological and biochemical sample testing services for others for scientific research purposes through the performance of assays in the fields of scientific and clinical research; laboratory biomarker analysis services and related data analysis, namely, data analysis relating to the detection and measurement of biomarkers in biological and biochemical samples in the fields of scientific and clinical research

Goods & Services

Biological assays for research purposes; biological kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific and research use; reagents for scientific purposes; reagents for medical research use Diagnostic reagents for medicinal and veterinary use; Biological medical and veterinary assays and reagents for medical and diagnostic testing purposes; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use Research and development in the field of assays for the detection and measurement of molecules, proteins, and peptides in biological samples and environmental samples; providing biological and biochemical sample testing services through the performance of assays in the fields of scientific and clinical research; laboratory biomarker analysis services and related data analysis, namely, data analysis relating to the detection and measurement of biomarkers in samples in the fields of scientific and clinical research

Goods & Services

Biological assays for research purposes; biological kits comprising reagents for the detection of biological analytes and for use in the fields of biological and diagnostic testing for industrial, scientific, and research use Reagents for scientific and medical research use; Diagnostic reagents for medicinal and veterinary use; Biological medical and veterinary assays and reagents for medical and diagnostic testing purposes; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use Laboratory consumable, namely, plates having multiple wells that can be used in chemical or biological analysis for scientific, laboratory, or medical research use; laboratory consumable, namely, plates having multi-well arrays that can be used in chemical or biological analysis for scientific, laboratory, or medical research use Research and development in the field of assays for the detection and measurement of molecules, proteins, and peptides in biological samples and environmental samples; Providing biological and biochemical sample testing services for others for scientific research purposes through the performance of assays in the fields of scientific and clinical research; laboratory biomarker analysis services and related data analysis, namely, data analysis relating to the detection and measurement of biomarkers in biological and biochemical samples in the fields of scientific and clinical research

Abstract

An electrochemical cell includes a plurality of working electrode zones disposed, and defining a pattern, on a surface of the cell and at least one auxiliary electrode disposed on the surface. The auxiliary electrode having a defined interfacial potential.

IPC Classes  ?

• G01N 27/49 - Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species
• G01N 27/327 - Biochemical electrodes

Abstract

The present invention is directed to methods for improving assay specificity and performance in binding assays.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
• G01N 21/76 - ChemiluminescenceBioluminescence
• G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The invention relates to a load support unit for holding and adjusting the orientation of the load. The load support unit includes a lower arm, a upper arm, a mounting swivel, a swivel joint, a knuckle joint and a rotational joint. The mounting swivel allows the load support unit to rotate relative to its surroundings, the swivel joint allows the upper arm to rotate relative to the lower arm, the knuckle joint allows the upper arm to pivot in a rotational direction relative to the lower arm, and the rotational joint allows the load to rotate about the upper arm.

IPC Classes  ?

• F16M 11/14 - Means for attachment of apparatusMeans allowing adjustment of the apparatus relatively to the stand allowing pivoting in more than one direction with ball-joint
• F16M 11/20 - Undercarriages with or without wheels
• F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
• H04N 5/64 - Constructional details of receivers, e.g. cabinets or dust covers
• F16M 11/04 - Means for attachment of apparatusMeans allowing adjustment of the apparatus relatively to the stand

Abstract

The invention relates to a load support unit for holding and adjusting the orientation of the load. The load support unit includes a lower arm, a upper arm, a mounting swivel, a swivel joint, a knuckle joint and a rotational joint. The mounting swivel allows the load support unit to rotate relative to its surroundings, the swivel joint allows the upper arm to rotate relative to the lower arm, the knuckle joint allows the upper arm to pivot in a rotational direction relative to the lower arm, and the rotational joint allows the load to rotate about the upper arm.

IPC Classes  ?

• F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
• F16M 11/14 - Means for attachment of apparatusMeans allowing adjustment of the apparatus relatively to the stand allowing pivoting in more than one direction with ball-joint
• F16M 11/20 - Undercarriages with or without wheels

Abstract

The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables. The counterbalanced orbital shaking apparatus also incubates the assay consumables, and has a cooling system to maintain a preset temperature within the shaking apparatus.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B01L 1/00 - EnclosuresChambers
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 35/04 - Details of the conveyor system
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention relates to method and kits for highly specific isolation of extracellular vesicles (EVs) by targeting at least two EV surface markers. The invention further relates to methods and kits for analyzing EVs and their contents.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Goods & Services

Biological, biochemical and chemical analyzers for assays, selection, screening, testing, imaging, electrochemiluminescence and diagnostics of biological, biochemical and chemical samples; multi-well plates that can be used in chemical or biological analysis using electrochemiluminescence for scientific, laboratory or medical research use

Abstract

The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• B01F 31/22 - Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
• B01F 101/23 - Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
• B06B 1/16 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency making use of mechanical energy operating with systems involving rotary unbalanced masses
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Goods & Services

biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use. biological kits comprising reagents for detection and measurement of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use.

Abstract

The application is directed to a device housing. The device housing includes a first light device, the first light device including a first electrical supply configured to provide an electrical signal to a first light emitting diode (LED), the first LED separated from a first surface of a diffuser film by a space, wherein the diffuser film includes a second surface, opposite the first surface, the second surface configured to contact a first light pipe.

IPC Classes  ?

• F21V 8/00 - Use of light guides, e.g. fibre optic devices, in lighting devices or systems
• F21V 3/00 - GlobesBowlsCover glasses
• F21Y 113/10 - Combination of light sources of different colours
• F21Y 115/10 - Light-emitting diodes [LED]
• G08B 5/36 - Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmissionVisible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electromagnetic transmission using visible light sources

Goods & Services

(1) Biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use (2) Biological kits comprising reagents for detection and measurement of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use

Abstract

Provided herein are methods for analyzing a sample for an analyte using proximity-based extension, such as proximity extension strand displacement. Also provided are multiplexed methods for analyzing a sample using proximity-based extension. Provided herein are methods for screening for pairwise combination of binding moieties, for use in a sandwich-type assay. Also provided are compositions that find use in the present methods.

IPC Classes  ?

• C12Q 1/6823 - Release of bound markers
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
• C12Q 1/6851 - Quantitative amplification

Abstract

Provided herein are methods for analyzing a sample for an analyte using proximity- based extension, such as proximity extension strand displacement. Also provided are multiplexed methods for analyzing a sample using proximity-based extension. Provided herein are methods for screening for pairwise combination of binding moieties, for use in a sandwich- type assay. Also provided are compositions that find use in the present methods.

IPC Classes  ?

• C12Q 1/6804 - Nucleic acid analysis using immunogens

Abstract

The present disclosure provides methods for detecting, diagnosing, monitoring response to treatment or recurrence, or predicting overall survival, progression-free survival or duration of response in a subject suspected of having colorectal cancer (CRC) comprising performing one or more assays on at least one biological sample from the subject to detect one or more specific populations of EVs.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific, and research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific, and research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific, and research use Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use

Goods & Services

(1) Biological, biochemical and chemical electrochemiluminescence-based analyzers for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples; all of the forgoing excluding mass spectrometers, mass selective detectors, detectors for use with chromatographs, and goods or services for use with mass spectrometers, mass selective detectors and detectors for use with chromatographs (term considered linguistically incorrect by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations).

Goods & Services

(Based on Use in Commerce) Research and development in the field of assays for the detection and measurement of biological and chemical analytes in samples taken from cells, organisms, and the environment, and research and development regarding the selection, screening, testing, imaging and diagnostics of said samples; scientific research and development; (Based on Intent To Use) providing biological, chemical, biochemical, and environmental sample testing and diagnostics for others through the performance of assays in the fields of scientific and clinical research; monitoring for the presence of biological, chemical, biochemical, and environmental agents in the nature of pollutants, infectious agents, toxic agents, and hazardous agents for scientific research purposes; scientific services, namely, epidemiological testing for scientific research, clinical research, and medical research purposes; scientific research consulting in the field of assays for the detection and measurement of analytes in biological, chemical, biochemical, and environmental samples, and scientific research consulting regarding the selection, screening, testing, imaging and diagnostics of said samples

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and research use Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes and for use the fields of biological and diagnostic testing for medical and veterinary use Biological, biochemical and chemical analyzers for performing assays, selection, testing, imaging and diagnostics of biological, biochemical and chemical samples; cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use; downloadable and recorded software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information, controlling the operation of biochemical, biological and chemical analyzers, and designing and executing scientific, biological, biochemical and chemical testing and experiments

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and research use Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes and for use in the fields of biological and diagnostic testing for medical and veterinary use Downloadable and recorded software for the collection, editing, organizing, modifying, transmission, storage and sharing of data and information, controlling the operation of biochemical, biological and chemical analyzers, and designing and executing scientific, biological, biochemical and chemical testing and experiments; biological, biochemical and chemical analyzers for performing assays, selection, testing, imaging and diagnostics of biological, biochemical and chemical samples

Goods & Services

Research and development in the field of biology, chemistry, biochemistry, microbiology, and genetics; Scientific research and development

Abstract

Devices and methods for a microplate lid configured to cover a microwell assay plate are provided. A microplate lid includes a lid panel surrounded by a lid frame. Sidewalls extend downwardly from lid frame. The microplate lid includes various features to improve performance, including features to improve stickability, reduce warping, reduce sample contamination, reduce wear, reduce sample evaporation, facilitate robotic handling, and provide other benefits.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are scaled.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• F16K 11/074 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces

Abstract

The invention relates to a container for holding at least two vials. The container includes a back plate, a top wall, a bottom wall, a first sidewall and a second sidewall. The container also includes a clip disposed on a surface of the back plate, a first plurality of knobs and a second plurality of knobs. The container further includes cutouts in the bottom wall, the first sidewall and the second sidewall to allow access to the at least two vials within the container. The clip, the first plurality of knobs, and the second plurality of knobs are configured to retain the at least two vials within the container.

IPC Classes  ?

• B01L 9/06 - Test-tube standsTest-tube holders

Abstract

The invention relates to a container for holding at least two vials. The container includes a back plate, a top wall, a bottom wall, a first sidewall and a second sidewall. The container also includes a clip disposed on a surface of the back plate, a first plurality of knobs and a second plurality of knobs. The container further includes cutouts in the bottom wall, the first sidewall and the second sidewall to allow access to the at least two vials within the container. The clip, the first plurality of knobs, and the second plurality of knobs are configured to retain the at least two vials within the container.

IPC Classes  ?

• B01L 9/06 - Test-tube standsTest-tube holders
• A61J 1/16 - Holders for containers
• B65D 25/10 - Devices to locate articles in containers

Abstract

The invention relates to methods for conducting solid-phase binding assays. Onc example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6816 - Hybridisation assays characterised by the detection means
• C12Q 1/6876 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

Oligonucleotides, methods and kits are provided for detecting, identifying or quantifying one or more target analytes in a sample as well as methods for immobilizing oligonucleotides onto a support surface.

IPC Classes  ?

• C12Q 1/682 - Signal amplification

Abstract

In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier, and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.

IPC Classes  ?

• G06Q 30/0201 - Market modellingMarket analysisCollecting market data
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G01N 35/04 - Details of the conveyor system
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G06F 16/21 - Design, administration or maintenance of databases
• G06F 16/951 - IndexingWeb crawling techniques
• G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
• G06Q 10/10 - Office automationTime management
• G06Q 30/0601 - Electronic shopping [e-shopping]
• G07C 9/27 - Individual registration on entry or exit involving the use of a pass with central registration
• G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16Z 99/00 - Subject matter not provided for in other main groups of this subclass

Abstract

The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum

Goods & Services

Automated assay systems comprising analyzers and other scientific equipment and apparatuses used for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples, not for medical purposes

Goods & Services

Biological, biochemical, environmental, genetic, chemical and scientific research and development in the fields of assays, selection, screening, testing, imaging and diagnostics; providing biological and biochemical sample testing for others through the performance of assays in the fields of scientific and clinical research.

Abstract

The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

IPC Classes  ?

• G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
• G01N 27/327 - Biochemical electrodes
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
• G01T 1/00 - Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
• G01T 1/02 - Dosimeters

Abstract

Provided herein are systems, methods, and apparatuses for providing a real-time global bio-surveillance and response solution. The systems and apparatuses may include one or more sentinel subsystems and one or more surge subsystems that each include a real-time, cloud-based, distributed, interconnected set of hardware, software, and/or firmware for comprehensive surveillance, complete detection, and immediate response various to biological, chemical, and/or bio-chemical anomalies, for example, a new or emerging pathogen or other health condition.

IPC Classes  ?

• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu
• G01N 21/76 - ChemiluminescenceBioluminescence
• G06Q 50/40 - Business processes related to the transportation industry
• G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Goods & Services

Apparatus used to house multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use and to feed such plates into biological, biochemical and chemical electrochemiluminescence-based analyzers for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations); all of the forgoing excluding mass spectrometers, mass selective detectors, detectors for use with chromatographs, and goods or services for use with mass spectrometers, mass selective detectors and detectors for use with chromatographs; biological, biochemical and chemical electrochemiluminescence-based analyzers for performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples; all of the forgoing excluding mass spectrometers, mass selective detectors, detectors for use with chromatographs, and goods or services for use with mass spectrometers, mass selective detectors and detectors for use with chromatographs. Research and development in the fields of biological and chemical assays, and their uses in selection, screening, testing, imaging and diagnostics; providing biological, environmental, biochemical, and chemical sample testing for others through the performance of assays in the fields of scientific and clinical research; all of the foregoing solely for use with biological, biochemical, and chemical electrochemiluminescence-based analyzers, reagents, cartridges, multi-well plates, and kits for use in performing assays, selection, screening, testing, imaging and diagnostics of biological, biochemical, environmental and chemical samples (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations); all of the foregoing excluding mass spectrometers, mass selective detectors, detectors for use with chromatographs, and goods or services for use with mass spectrometers, mass selective detectors and detectors for use with chromatographs (Term considered too vague by the International Bureau pursuant to Rule 13 (2) (b) of the Regulations.).

Abstract

The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1β, IL-2, IL-6, IL-10, IL-22, IP-10, TNFα, TSLP, NFL, and/or NFH.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 21/66 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/686 - Polymerase chain reaction [PCR]

Goods & Services

Biological assays for research purposes; biological kits comprising arrays and reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising reagents for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use; biological kits comprising arrays for detection and measurement of biological analytes for use in the fields of biological and diagnostic testing for industrial, scientific and/or research use. Biological medical and veterinary assays for medical and diagnostic testing purposes; biological kits comprising arrays and reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising arrays for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use; biological kits comprising reagents for detection of biological analytes and for use in the fields of biological and diagnostic testing for medical and/or veterinary use. Multi-well plates that can be used in chemical or biological analysis for scientific, laboratory or medical research use; cartridges for use in chemical or biological analysis for scientific, laboratory or medical research use.

Abstract

The invention relates to methods, compositions, and kits for detection of hydrolase enzyme activity in a sample.

IPC Classes  ?

• C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
• C12Q 1/682 - Signal amplification

Abstract

A gripper assembly for a robotic arm includes a gripper finger having a first end and a second end, a gripper pad pivotably coupled to the gripper finger such that the gripper pad is permitted to rotate about a rotational axis relative to the gripper finger, the gripper pad having a pair of sides with one of the sides forming a gripping surface configured to grip an object, and a proximal side located between the pair of sides, and a gripper pad aligner including a pad alignment element coupled to the gripper pad and a finger alignment element coupled to the gripper finger, wherein the pad alignment element is coupled to the finger alignment element and configured to apply an aligning torque to the gripper pad that, when applied, rotates the gripper pad toward a first angular orientation about the rotational axis between the gripper pad and the gripper finger.

IPC Classes  ?

• B25J 15/00 - Gripping heads

Abstract

A gripper assembly for a robotic arm includes a gripper finger having a first end and a second end, a gripper pad pivotably coupled to the gripper finger such that the gripper pad is permitted to rotate about a rotational axis relative to the gripper finger, the gripper pad having a pair of sides with one of the sides forming a gripping surface configured to grip an object, and a proximal side located between the pair of sides, and a gripper pad aligner including a pad alignment element coupled to the gripper pad and a finger alignment element coupled to the gripper finger, wherein the pad alignment element is coupled to the finger alignment element and configured to apply an aligning torque to the gripper pad that, when applied, rotates the gripper pad toward a first angular orientation about the rotational axis between the gripper pad and the gripper finger.

IPC Classes  ?

• B25J 15/00 - Gripping heads
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

Goods & Services

(1) Biological, biochemical, environmental, genetic, chemical and scientific research and development in the fields of assays, selection, screening, testing, imaging and diagnostics; providing biological and biochemical sample testing for others through the performance of assays in the fields of scientific and clinical research.

Abstract

Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

IPC Classes  ?

• G02B 7/36 - Systems for automatic generation of focusing signals using image sharpness techniques
• G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• G01N 21/64 - FluorescencePhosphorescence
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The disclosure is directed to a package for containing a plurality of substantially rectangular assay plates, each plate having a peripheral flange. In one embodiment, the package comprises a cavity having extending therein one or more sloped buttress elements spaced across at least a portion of a top corner, and one or more adjacent protrusions extending from the bottom and at least partially up one or both sidewalls, each set of protrusions forming grooves therebetween into which fit the flanges of respective assay plates. The package can comprise a transparent polymer through which product information located on the assay plates can be read or scanned.

IPC Classes  ?

• B65D 25/10 - Devices to locate articles in containers
• B65D 43/16 - Non-removable lids or covers hinged for upward or downward movement
• B65D 85/44 - Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for crockery

Abstract

Electrochemical cells and methods for their production are provided. In particular, multi-well assay plates including multi-electrode wells are provided. The multi-electrode wells contain multiple electrodes that are electrically isolated from one another, permitting the various electrodes of the various wells to be addressed in any suitable combination.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Electrochemical cells and methods for their production are provided. In particular, multi-well assay plates including multi-electrode wells are provided. The multi-electrode wells contain multiple electrodes that are electrically isolated from one another, permitting the various electrodes of the various wells to be addressed in any suitable combination.

IPC Classes  ?

• G01N 27/417 - Systems using cells and probes with solid electrolytes
• G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
• G01N 27/327 - Biochemical electrodes