The Children's Hospital of Philadelphia (chop)

United States of America

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IPC Class
A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid 1
C07C 13/16 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring 1
C07D 213/61 - Halogen atoms or nitro radicals 1
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1.

BENZALDEHYDE COMPOUNDS WITH DIRECT POLYMER DESTABILIZING EFFECTS TO TREAT SICKLE CELL DISEASE

      
Application Number US2023036751
Publication Number 2024/102304
Status In Force
Filing Date 2023-11-03
Publication Date 2024-05-16
Owner
  • VIRGINIA COMMONWEALTH UNIVERSITY (USA)
  • ILLEXCOR HOLDINGS, LLC. (USA)
  • KING ABDULAZIZ UNIVERSITY (Saudi Arabia)
  • CHILDREN'S HOSPITAL OF PHILADELPHIA (CHOP) (USA)
Inventor
  • Safo, Martin
  • Zhang, Yan
  • Fleischman, Andrew
  • Light, David
  • El-Araby, Moustafa
  • Omar, Abdelsattar
  • Abdulmalik, Osheiza

Abstract

Compounds and methods for preventing and/or treating one or more symptoms of sickle cell diseases (SCD) by administering at least one of the compounds are provided. The compounds are chemically modified to increase bioavailability and activity, e.g., so that the compounds prevent adhesion and sickling of red blood cells (RBCs).

IPC Classes  ?

  • C07C 13/16 - Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with a six-membered ring
  • C07D 213/61 - Halogen atoms or nitro radicals
  • A61P 7/00 - Drugs for disorders of the blood or the extracellular fluid