Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Mannucci, Serena
Griselli, Alessio
Stefanini, Alessio
Abstract
The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl)chromans of formula I.
The intermediates thus obtained can be used for the synthesis of Nebivolol.
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Mannucci, Serena
Griselli, Alessio
Stefanini, Alessio
Abstract
The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl) chromans of formula I. The intermediates thus obtained can be used for the synthesis of Nebivolol.
C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparations; filled auto-injectors and
syringes containing pharmaceutical preparations for medical
purposes. Syringes and injectors for medical use.
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug compound is described. The device has a sliding sheath which, when depressed with its front end against the injection site, interacts with cam means to activate triggering of a plunger, thus controlling delivery of a drug dose. Plunger guide means are provided for controlling the triggering sequence and means for arming the device in the dose delivery condition. Automatic needle re-sheathing and resetting of a lock-out condition after each dose is delivered are also provided.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
42.
Device for the automatic injection of two doses of a medicament
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug is described. The device has a slide and cam means, a syringe unit with a piston, and guide means. The axial movement of the slide initiated by a user by depressing its front end against an injection site, causes an angular displacement of the cam means that, in cooperation with the guide means, controls movement of the syringe piston and therefore administration of a drug dose.
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Mauro, Sandro
Fattori, Daniela
D'Andrea, Piero
Cipollone, Amalia
D'Andrea, Enzo
Ercolano, Carmela
Abstract
The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Cipollone, Amalia
Fattori, Daniela
Abstract
The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug is disclosed, comprising a slide (30) and cam means (23, 28, 36), a syringe unit (6) with a piston (8), and guide means (26) thereof; the axial movement of the slide initiated by the user by depressing its front end against the injection site, causes the angular displacement of the cam means that, in cooperation with the guide means, controls the movement of the syringe piston and therefore the administration of a drug dose.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug compound comprising a sliding sheath (30) which, when depressed with its front end (3) against the injection site, interacts with cam means (26, 27, 28) to activate the triggering of a plunger (8), controlling the delivery of a drug dose. Plunger guide means (44) are provide for controlling the triggering sequence and means (4) for arming the device in the dose delivery condition. Automatic needle re-sheathing and resetting of a lock-out condition after each dose is delivered are provided. The number of the device components is reduced resulting in a simpler structure and cost reduction.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
47.
DEVICE FOR THE AUTOMATIC INJECTION OF TWO DOSES OF A MEDICAMENT
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug is disclosed, comprising a slide (30) and cam means (23, 28, 36), a syringe unit (6) with a piston (8), and guide means (26) thereof; the axial movement of the slide initiated by the user by depressing its front end against the injection site, causes the angular displacement of the cam means that, in cooperation with the guide means, controls the movement of the syringe piston and therefore the administration of a drug dose.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Driver, Philip Jerome
Moseley, Guy Conwyn Julian
Lewis, Scott Alexander
Abstract
A device for the automatic injection of doses of a drug compound comprising a sliding sheath (30) which, when depressed with its front end (3) against the injection site, interacts with cam means (26, 27, 28) to activate the triggering of a plunger (8), controlling the delivery of a drug dose. Plunger guide means (44) are provide for controlling the triggering sequence and means (4) for arming the device in the dose delivery condition. Automatic needle re-sheathing and resetting of a lock-out condition after each dose is delivered are provided. The number of the device components is reduced resulting in a simpler structure and cost reduction.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Ryan, Patrick J.
Middleton, Max William
Butcher, Christopher Edward
Abstract
A two-dose autoinjector for a medicament wherein the locking and releasing of the drive spring of the autoinjector is controlled through stepped guides with ramps for two successive slidings of slides operated by the spring and connected with the syringe and plunger. The guides and the slides are pivotable relative to one another and the sliding direction, while the syringe can only slide axially. To enable or disable the sliding of the slides within the guides an angularly angularly mobile arming member is provided formed with a guide track substantially equal to that of the stationary member where the guides are formed.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
50.
PROCESS FOR THE PREPARATION OF EPOXIDES AS INTERMEDIATES FOR THE SYNTHESIS OF NEBIVOLOL
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Cipollone, Amalia
Fattori, Daniela
Bartoli, Sandra
D'Andrea, Piero
Abstract
The present invention relates to a novel process of synthesis of epoxides, 6-fluoro-2- (oxiran-2-yl) chroman (Figure 1), intermediates for the synthesis of nebivolol, depicted in Scheme (1), enabling to obtain the above- mentioned epoxides in a racemic or semichiral form.
C07D 311/58 - Benzo [b] pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulfur atoms in position 2 or 4
C07D 407/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Cipollone, Amalia
Fattori, Daniela
Abstract
The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Mauro, Sandro
Fattori, Daniela
D'Andrea, Piero
Cipollone, Amalia
Abstract
The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Mauro, Sandro
Fattori, Daniela
Cipollone, Amalia
D'Andrea, Piero
Abstract
The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Melani, Francesco
Giuliani, Sandro
Maggi, Carlo Alberto
Abstract
The present invention relates to an association of active principles, i.e. of a xanthine oxidase inhibitor with one or more calcium antagonists, pharmaceutical compositions comprising said active principles, for use in a human or veterinary therapeutic treatment, and methods for the preparation thereof.
A61K 31/4422 - 1,4-Dihydropyridines, e.g. nifedipine, nicardipine
A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Menarini International Operations Luxembourg S.A. (Luxembourg)
Inventor
Melani, Francesco
Giuliani, Sandro
Maggi, Carlo Alberto
Abstract
The present invention relates to the association of active principles, i.e. of a xanthine oxidase inhibitor with one or more HMG CoA reductase inhibitors, pharmaceutical compositions comprising said active principles, for use in a human or veterinary therapeutic treatment, and methods for the preparation thereof.
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Melani, Francesco
Giuliani, Sandro
Maggi, Carlo Alberto
Abstract
The present invention relates to an association of active principles, i.e. of a xanthine oxidase inhibitor with one or more angiotensin II receptor antagonists, pharmaceutical compositions comprising said active principles, for use in a therapeutic treatment in humans or animals, and methods for the preparation thereof.
A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61K 31/4178 - 1,3-Diazoles not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
57.
ASSOCIATION OF THE XANTHINE OXIDASE INHIBITOR FEBUXOSTAT AND METFORMIN AND USE THEREOF
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Melani, Francesco
Giuliani, Sandro
Maggi, Carlo, Alberto
Abstract
The present invention relates to the association of active principles, i.e. of a xanthine oxidase inhibitor with a biguanide derivative, preferably metformin, pharmaceutical compositions comprising said active principles, for use in a human or veterinary therapeutic treatment, and methods for the preparation thereof.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Ryan, Patrick J.
Middleton, Max William
Butcher, Christopher Edward
Abstract
A two-dose autoinjector for a medicament wherein the locking and releasing of the drive spring (27) of the autoinjector is controlled through stepped guide means (16, 24) with ramps for two successive slidings therealong of slide means (28, 29) operated by the spring and connected with the syringe (21) and relevant plunger (26). The guide means and the slide means are pivotable relative to one another and the sliding direction, while the syringe can only slide axially, and the triggering control for each sliding is obtained by pressing a trigger (30), axially slidable relative to a stationary member (1), against the patient's skin to push the slide means first into one ramp and then into the other ramp of the guide means. To enable or disable the sliding of the slide means within the guide means a angularly mobile arming member (11) is provided formed with a guide track (14) substantially equal to that of the stationary member where the guide means are formed. Following two subsequent angular arming displacements of the mobile member relative to the stationary member the ramps and the guide track are radially aligned to enable the slide means to slide under the action of the spring and therefore deliver the first dose and then the second dose.
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
59.
DEVICE FOR THE AUTOMATIC INJECTION OF TWO DOSES OF A MEDICAMENT
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Edhouse, Mark Jeffrey
Ryan, Patrick J.
Middleton, Max William
Butcher, Christopher Edward
Abstract
A two-dose autoinjector for a medicament wherein the locking and releasing of the drive spring (27) of the autoinjector is controlled through stepped guide means (16, 24) with ramps for two successive slidings therealong of slide means (28, 29) operated by the spring and connected with the syringe (21) and relevant plunger (26). The guide means and the slide means are pivotable relative to one another and the sliding direction, while the syringe can only slide axially, and the triggering control for each sliding is obtained by pressing a trigger (30), axially slidable relative to a stationary member (1), against the patient's skin to push the slide means first into one ramp and then into the other ramp of the guide means. To enable or disable the sliding of the slide means within the guide means a angularly mobile arming member (11) is provided formed with a guide track (14) substantially equal to that of the stationary member where the guide means are formed. Following two subsequent angular arming displacements of the mobile member relative to the stationary member the ramps and the guide track are radially aligned to enable the slide means to slide under the action of the spring and therefore deliver the first dose and then the second dose.
A61M 5/315 - PistonsPiston-rodsGuiding, blocking or restricting the movement of the rodAppliances on the rod for facilitating dosing
A61M 5/20 - Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Cipollone, Amalia
Fattori, Daniela
Abstract
The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Bartoli, Sandra
Cipollone, Amalia
Fattori, Daniela
Abstract
The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1), comprised of a reduced number of high-yield steps, and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1), allowing to avoid complex chromatographic separations.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Pharmaceutical and veterinary products; sanitary products
for medical use; dietetic substances adapted for medical
use, food for babies; plasters, materials for dressings;
material for dental fillings and dental impressions;
disinfectants; pesticides; fungicides, herbicides.
MENARINI INTERNATIONAL OPERATION LUXEMBOURG SA (Luxembourg)
Inventor
Goso, Cristina
Fedi, Valentina
Maggi, Carlo, Alberto
Abstract
There are disclosed pharmaceutical compositions containing MUC 16 fragments with antigenic activity and their use for the preparation of antitumor vaccines.
A61K 39/00 - Medicinal preparations containing antigens or antibodies
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
36 - Financial, insurance and real estate services
Goods & Services
administration of pharmaceutical reimbursement programs; assisting patients in enrolling in pharmaceutical reimbursement programs assisting patients, pharmacists, and physicians in collecting from pharmaceutical reimbursement programs
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (Luxembourg)
Inventor
Flemming, Jens
Gröger, Karsten
Schmitz, Reinhard
Manzini, Stefano
Abstract
The present invention refers to a pharmaceutical composition for parenteral administration as vaccine comprising a monoclonal antibody and as adjuvant an aluminium derivative.
A61K 31/4745 - QuinolinesIsoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenanthrolines
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Produits pharmaceutiques appartenant à la classe
thérapeutique des antihypertenseurs, de l'hypertension, de
post infarctus du myocarde et des défectuosités cardiaques
congestives.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; with the exclusion of products for the treatment of irritating and inflammatory phenomena of every nature relating to the skin and mucous membranes. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; with the exclusion of dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides; with the exclusion of oral care products. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides; herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; suture materials.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants for pharmaceutical and veterinary use; preparations for destroying vermin; fungicides; herbicides; with the exclusion of pharmaceutical products for preventing and treating central nervous system diseases, including pharmaceutical products for the treatment of alcohol dependence and with the exclusion of analgesic preparations, anti-inflammatory preparations, antipyretic preparations and preparations for the prevention or traetment of cardiovascular conditions. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; with the exclusion of pharmaceutical products for the treatment of respiratory diseases and in particular expectorants. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Savons; parfumerie, huiles essentielles, cosmétiques,
produits pour la chevelure; dentifrices. Produits pharmaceutiques (à l'exception des produits pour le
traitement des affections rhumatismales et des inflammations
des tissus mous); produits vétérinaires; produits pour
l'hygiène et les soins de la peau et de la chevelure;
substances diététiques à usage médical, aliments pour bébés.