An applicator assembly includes a housing, a cap releasably secured to the housing, and a wearable sensor device disposed within the housing. The sensor device includes a sensor tail with a sensing element for detecting characteristics of bodily fluid beneath the patient's skin. A pressure-sensitive adhesive layer on the sensor device allows the sensor device to be affixed to the patient's skin by selectively activating an actuation device within the housing. Activating the actuation device moves the sensor device from an initial stowed position within the housing to an actuated position wherein the adhesive layer protrudes from the housing. The applicator assembly includes a release liner covering at least part of the adhesive layer that is removable prior to securing the sensor device to the patient's skin.
Examples of monitoring and transmission of wound parameters of a wound site by a negative 5 pressure wound therapy system, are described. In an example, a system may determine a rate of change in value of a wound parameter of wound subjected to a negative pressure applied by a negative pressure device. Thereafter, the rate if change may be compared with a predefined value. Thereafter, a sampling rate of sensors may be varied from a current sampling rate to a first sampling rate, wherein the sampling rate is varied in response to comparison of the rate of change in the value of the wound parameter with 0 the predefined value.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
3.
Composition and Process for Treating a Disorder in the Oral Cavity of a Mammal
The invention relates to a composition, in particular to a swellable composition, for use in a process of treating a disorder in the oral cavity of a mammal. The composition comprises a guanidinyl-containing polymer, carrageenan, filler and a paste-forming component. During the process an active substance for treating the disorder is applied to and absorbed by the composition. The composition can be used for various purposes, including treating calculus, treating periodontitis, treating tissue lesions and for endodontic treatments.
Attachment systems for attaching a vascular device to a patient includes an adhesive and a polymeric hardgood article for holding a vascular device. One surface of the polymeric hardgood article (140,240,340) is attached to the adhesive layer (110A,130A,220,230). The opposite surface of the polymeric hardgood article has a hole that passes through the entire article and a pathway adjacent to the hole. The pathway has a channel (343,443) extending to an edge surface, or a series of posts (541), where the series of posts define the pathway.
Phosphate and arginine-containing compositions and methods of suppressing microbial virulence are provided. By suppressing virulence, administration and/or application of the medical compositions can be used to prevent, mitigate, or treat a microbial infection.
Absorbent medical articles include a first absorbent layer with a radio opaque element located on the surface of the first absorbent layer. The radio opaque element has at least one segment that is non-linear and has at least one vertex, the vertex defines an angle of at least 15° and less than 165°. The radio opaque element may be a continuous or discontinuous element. The absorbent medical article may include additional absorbent layers. The radio opaque element makes the absorbent medical article detectable if left inside a patient.
A61F 13/44 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators with radio-opaque material or signalling means for residual material
A61F 13/15 - Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the bodySupporting or fastening means thereforTampon applicators
A61F 13/36 - Surgical swabs, e.g. for absorbency or packing body cavities during surgery
A61F 13/84 - Accessories, not otherwise provided for, for absorbent pads
7.
Incentivized Crowd Funding System with Blockchain Security for Internal Innovation by an Organization
Crowd funding for innovation includes distributing a proposal with a description of a project idea, an amount of funds requested, and a time frame for raising the funds. Ownership of the project is transferred to an entity or between entities, which receives contributions from contributors and for each of the received contributions converts the contribution to a corresponding amount of virtual coin, performs a blockchain operation on the coin, and adds the contribution to the funds. The virtual coin is subject to a blockchain operation to uniquely identify and trace it, establishing confidence in the transaction between contributor and entity or between entities. If the funding goal is complete within the time frame, the entity converts the coins to fiat currency and releases the money to the requestor. After completion of the project, the entity or entities determines if the project is successful and can commercialize successful projects. For certain successful projects, the entity or entities can also distribute funds to the contributors.
PROCESS AND APPARATUS FOR MANUFACTURING FOAM DRESSINGS, FOAM DRESSINGS MADE THEREFROM, AND COMPOSITION AND PROCESS OF PREPARING FOAM PRECURSOR MIXTURES
Process for manufacturing foam dressing comprises compounding a foam precursor mixture, the foam precursor mixture comprising a matrix-forming material and a biomaterial. Supercritical carbon dioxide is mixed with the foam precursor mixture to form a foam block that is passed through an extrusion die to form a foam slab. The foam slab is calendered to obtain a foam dressing. Process for preparing a foam precursor mixture for use in manufacturing a foam dressing comprises mixing a matrix-forming material and a biomaterial to form an initial mixture and drying the initial mixture to substantially remove moisture therefrom, thereby obtaining the foam precursor mixture.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
A61L 15/46 - Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
Pressure sensitive adhesive articles include a substrate with a first major surface and a second major surface, and a pressure sensitive adhesive layer disposed on at least a portion of the first major surface of the substrate. The pressure sensitive adhesive layer is an E-beam cured composition of a (meth)acrylate-based polymer that is free from acidic-functional or amide-functional groups and at least one tackifier that is a hydrogenated hydrocarbon resin. The pressure sensitive adhesive layer has a static shear of at least 600 minutes to protein leather.
Methods for automatically removing collisions between digital mesh objects and moving digital mesh objects between spatial arrangements. The collisions are removed from a set of digital mesh objects using a perturbation method or a mesh deformation method. After removing the collisions, the digital mesh objects are output in a state without collisions between them. The digital mesh objects can be moved between initial and final states based upon motion constraints of the mesh objects and interpolated states of them between the initial and final states. Based upon the constraints and interpolated states, a number of states for movement of the set of digital mesh objects is determined either collectively for the set or individually for each mesh object. The states can be used as digital setups for dental or orthodontic treatment planning.
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
An aqueous oral care composition includes calcium, fluoride, citrate, and water. The composition includes at least 2 moles of citrate for every 3 moles of calcium, and at least 1 mole of fluoride for every 1 mole of calcium. Water is present in the composition in an amount of at least 50 wt %, based on the total weight of the composition. The composition is a solution.
Provided in the present invention are a gel hand sanitizer and a method for preparing a gel hand sanitizer. The gel hand sanitizer comprises, based on the total weight thereof: 75-85 wt % of a monohydric alcohol; 0.05-1 wt % of hydrogen peroxide; 0.1-2 wt % of a thickener; 0.01-1 wt % of a neutralizer; and the balance of water. The neutralizer has a structure represented by the general formula: CaHbNcOd, where a≥6, b≥15, 1≤c<3, and 1≤d<6. According to the technical solution of the present invention, a gel hand sanitizer with good stability, moisture retention, and good fungi and virus killing effects can be provided.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 17/00 - Barrier preparationsPreparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
13.
Defect Detection, Mesh Cleanup, and Mesh Cleanup Validation in Digital Dentistry
Systems and techniques for training one or more neural networks to automatically identify one or more aspects of a digital representation used in digital oral care are disclosed including identifying one or more aspects of the first digital representation for which additional processing is to be performed, based on a list of 3D elements, generating a predicted representation by labeling those one or more aspects for which additional processing is to be performed, generating an accuracy score that specifies a difference between the one or more predicted representations and one or more respective reference representations that identify the one or more aspects of the first digital representation for which additional processing is to be performed, and modifying at least one aspect of the neural network based on the accuracy score.
Described herein are methods of separating nucleic acids using a solid phase comprising a multimodal ligand comprising a nitrogen-containing heterocycle, wherein the nitrogen-containing heterocycle has a pKa value of 3.5 to 9.5. The pH and/or ionic strength of the loading buffer and eluting buffer(s) are adjusted to selectively bind and elute nucleic acids.
Described herein is a chemically-functionalized fiber and a method of making, wherein a sheath-core fiber, comprises a nylon sheath layer is chemically-functionalized with an aqueous reaction mixture comprising an aminoalkyl (meth)acryloyl monomer. Such chemically-functionalized fibers disclosed herein may be used to filter fluids.
B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres
D01F 8/06 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyolefin as constituent
D01F 8/12 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyamide as constituent
D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
A securement device includes a main body including a first major surface, a second major surface opposite to the first major surface, a perimeter extending between the first and second major surfaces, and a slot extending from the perimeter and extending through the main body from the first major surface to the second major surface. The securement device further includes a clip extending from the first major surface and a plurality of microhooks extending from the second major surface. Each microhook includes a base disposed on the second major surface and a tip distal to the base. The plurality of microhooks includes at least one microhook and at least one opposing microhook facing the at least one microhook, such that the respective tips of the at least one microhook and the at least one opposing microhook point towards each other.
Described herein is a chemically-functionalized spun-bond nylon nonwoven and a method of making, wherein a homogeneous nylon spun-bond fiber is chemically-functionalized with an aqueous reaction mixture comprising an aminoalkyl (meth)acryloyl monomer. Such chemically-functionalized nonwovens disclosed herein may be used to filter fluids.
D06M 10/00 - Physical treatment of fibres, threads, yarns, fabrics or fibrous goods made from such materials, e.g. ultrasonic, corona discharge, irradiation, electric currents or magnetic fieldsPhysical treatment combined with treatment with chemical compounds or elements
D06M 13/41 - Amides derived from unsaturated carboxylic acids, e.g. acrylamide
D06M 15/267 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated carboxylic acidsSalts or esters thereof of unsaturated carboxylic esters having amino or quaternary ammonium groups
The present disclosure provides an apparatus for post-curing an article, as well as a system, methods, and post-cured articles. The apparatus includes a housing, a chamber disposed in the housing, at least two light emitting diodes (LEDs) disposed within the housing, and a user interface disposed on an exterior of the housing. The chamber is adaptable to each of an open, closed, and hermetically sealed configuration. The chamber includes a material transparent to actinic radiation and light from the LEDs enters the chamber from more than one direction. The user interface includes a display and program switches configured to adjust at least three operational parameters of the apparatus. The apparatus further includes a vacuum pump operatively coupled to the chamber. The system includes the apparatus and an article. An article includes layers of at least one photopolymerized crosslinked composition and a low extractable component content. A method of post-curing an article includes obtaining an article, placing the article in an apparatus, inputting a post-cure program or accessing a saved post-cure program through the user interface, and running the post-cure program. The post-cure program includes light intensity provided by a light source and length of time of light provided by the light source, plus a delay time between initiation of light provided by the light source and initiation of vacuum pulled by the vacuum pump and/or a delay time between initiation of vacuum pulled on an interior of the chamber by the vacuum pump and initiation of light provided by the light source.
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
B29C 71/04 - After-treatment of articles without altering their shapeApparatus therefor by wave energy or particle radiation
Wound care compositions, wound care articles, and methods of preparation thereof are described herein. Methods of treating wounds with wound care compositions and wound care articles are also described.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
Systems and methods are disclosed for generating data structures related to interproximal reduction (IPR) in orthodontic treatment using machine learning (ML) models. The systems and methods involve receiving a digital representation of a patient's dentition and providing the digital representation to a partially trained ML model. The partially trained ML model, which includes a first and second module, generates predictions for one or more IPR cut surfaces based on the patient's dentition. The partially trained ML model is further trained by generating predicted IPR cut surfaces, quantifying the difference between the predicted surfaces and corresponding reference surfaces, generating a loss value based on the difference, and modifying the ML model based on the loss value to create a modified ML model. These systems and methods aim to improve the accuracy and efficiency of generating IPR cut surfaces in orthodontic treatment using machine learning techniques.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
Systems and methods are described for generating accurate predictions of the post-treatment anatomy of a patient. The methods involve receiving one or more oral care arguments that describe the desired output from a trained machine learning model. One or more noisy representations of the patient's face and/or post-treatment dentition can be used to train a denoising diffusion probabilistic model. In deployment, an initially noisy image can be denoised, with conditioning on latent representations of the patient's pre-treatment photo and the post- restoration dentition. The methods may generate a digital representation of the patient's post-treatment appearance. These systems and methods enable improved predictive accuracy and enable treatment planning for orthodontics and dental restorative treatments.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 6/51 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications for dentistry
G06T 19/00 - Manipulating 3D models or images for computer graphics
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
Wound care compositions and wound care articles are described herein. Methods of treating wounds with wound care compositions and wound care articles are also described.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
Wound care compositions, wound care articles, and methods of treating a wound are described herein. Methods of preparing wound care compositions and wound care articles are also described.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
An apparatus for coupling a negative-pressure source to a tissue site includes a base having a first side and a second side, a post member extending outward from the first side of the base, a port coupled to the post member, and a top flange coupled to the post member opposite to the base. The post member may include a winding surface configured to carry a conduit. The port may be configured to fluidly couple the conduit to the tissue site through an aperture in the second side of the base. The top flange may include a deformable lip configured to move between an open position and a closed position. The deformable lip may be positioned closer to the first side of the base in the closed position than in the open position.
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
25.
IMPROVED DRESSINGS AND SYSTEMS FOR NEGATIVE-PRESSURE WOUND THERAPY AND INSTILLATION THERAPY HAVING LOW-VOLUME MANIFOLDS AND BYPASS INSTILLATION PASSAGES
A system for treating a tissue site with negative-pressure therapy includes a dressing configured to be placed adjacent to the tissue site. The dressing includes a first film layer, a manifold, and a second film layer. A plurality of fenestrations is disposed through a first side and a second side of the first film layer and is configured to be exposed to the tissue site. The first side of the manifold is disposed adjacent to the second side of the first film layer, and a first side of the second film layer is disposed adjacent to the second side of the manifold. A negative-pressure passage is disposed through the second film layer, and a fluid-ingress passage is disposed through the second film layer, the manifold, and the first film layer. A negative-pressure source is fluidly coupled to the negative-pressure passage, and a fluid source coupled to the fluid-ingress passage.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 35/00 - Devices for applying media, e.g. remedies, on the human body
Apparatuses, systems, and methods for providing negative-pressure wound therapy are described. The system for treating a tissue site with negative-pressure includes a dressing and a dressing interface. The dressing includes a cover and a tissue interface. The cover includes a stand-off layer, a microsphere layer, a film layer, a bonding adhesive layer, and a sealing adhesive layer. The tissue interface includes a first surface with a film and a second surface positioned proximate to the tissue site. The dressing interface is configured to couple to the dressing. The dressing interface includes a first chamber, a first piercing element disposed in the first chamber, a second chamber, and a second piercing element disposed in the second chamber. The dressing interface is configured to draw fluid from the first chamber at a first predetermined pressure and to draw fluid from the second chamber at a second predetermined pressure.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
27.
ARTICLE FOR SECUREMENT TO SKIN AND METHOD OF USE THEREOF
An article for securement to a skin includes a sheet. In a planar undeformed shape, the sheet defines a plane, a longitudinal axis extending along a length of the sheet, and a transverse axis disposed in the plane and extending perpendicular to the longitudinal axis. The sheet includes a plurality of walls including a set of emergent walls. Each emergent wall includes at least one skin-penetrating feature tapering to a tip. Upon being stretched along the longitudinal axis, the sheet deforms from the planar undeformed shape to a non-planar deformed shape, such that each wall rotates outwardly from the plane about the transverse axis. In the non-planar deformed shape of the sheet, the at least one skin- penetrating feature of each emergent wall extends outwardly from the plane and is configured to at least partially penetrate the skin via the tip.
A biological indicator incubator includes a base, at least one well, and a display. The base is configured to support the biological indicator incubator on an external surface. The at least one well is configured to at least partially receive therein and incubate a biological indicator. The display is spaced apart from the base and includes at least one display portion. Each display portion from the at least one display portion is designated for displaying information pertaining to a corresponding well from the at least one well. The corresponding well is disposed adjacent to the display portion. The at least one display portion includes a graphical user interface that is configured to receive one or more user inputs. A biological indicator incubator system may include multiple biological indicator incubators.
Disclosed embodiments relate to devices and systems for providing both negative-pressure therapy and instillation. In some embodiments, both negative-pressure and instillation may be provided to a tissue site in a low-profile context that may also prevent siphoning of instillation fluid during negative pressure application. For example, a single bridge may include a negative-pressure pathway with supports and an instillation pathway, and the instillation pathway may be configured with respect to the negative-pressure pathway so that at least a portion of the instillation pathway collapses upon application of negative pressure to the negative-pressure pathway. Collapse of at least a portion of the instillation pathway may be sufficient to close the instillation pathway.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A system for treating a tissue site with negative pressure includes a dressing, a negative-pressure source, a micropump, and a controller. The dressing is configured to be positioned at the tissue site. The negative-pressure source is configured to supply the negative pressure to the dressing through a fluid pathway. The micropump is configured to be positioned in fluid communication with the fluid pathway. The controller is associated with the micropump and configured to generate an alert signal if a deviation condition is met in an actual operating frequency of the micropump.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
31.
APPARATUSES, KITS, AND METHODS FOR TISSUE INTERFACE PLACEMENT
Tissue interfaces, kits, and methods for treating an abdominal cavity. A tissue interface for use in an abdominal cavity includes a first contact layer, a second contact layer, a spacer layer, and a plurality of location tags. The first contact layer comprises a first plurality of perforations. The second contact layer comprises a second plurality of perforations. The spacer layer is disposed between the first contact layer and the second contact layer. The plurality of location tags are configured to be located by an identifier tool and to be positioned in a plurality of treatment areas within the abdominal cavity.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
32.
NEGATIVE PRESSURE WOUND THERAPY DRESSINGS, APPARATUSES, AND SYSTEMS
Apparatuses, dressings, and systems for negative pressure wound therapy. The apparatus includes a first film layer, a second film layer, and a plurality of protrusions. The first film layer includes a first surface configured to contact the tissue site, a second surface opposite the first surface, and a plurality of fenestrations. The second film layer includes a first surface configured to couple to the second surface of the first film layer and a second surface opposite the first surface. The plurality of protrusions are disposed between the second surface of the first film layer and the first surface of the second film layer. The plurality of protrusions are integrally formed on at least one of the second surface of the first film layer or the first surface of the second film layer.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
33.
ANTIMICROBIAL COMPOSITIONS AND ARTICLES MADE THEREFROM
An antimicrobial-impregnated adhesive sheet includes an antimicrobial and a pressure-sensitive adhesive. The sheet includes a first major surface and a second major surface. The sheet also includes a plurality of surface depressions extending inwardly from the first major surface, wherein the distribution of surface depressions is uniform or substantially uniform. An available fraction of antimicrobial at the first major surface is at least 30%, based on the total amount of antimicrobial in the antimicrobial-impregnated adhesive sheet.
The invention relates to a radiation-curable composition for additive-manufacturing processes, the composition comprising (meth)acrylate component A1 comprising a polyalkylene oxide backbone, with at least two (meth)acrylate moieties, not comprising a urethane moiety, and having a molecular weight Mw of at least 2,000 g/mol, (meth)acrylate component A1 being present in an amount of 50 to 85 wt.%, (meth)acrylate component A2 with at least two (meth)acrylate moieties, comprising in addition at least two urethane moieties, and having a molecular weight Mw of at most 1,000 g/mol, (meth)acrylate component A2 being present in an amount of 5 to 20 wt.%, (meth)acrylate component A3 with only one (meth)acrylate moiety, and having a molecular weight of at most 500 g/mol, (meth)acrylate component A3 being present in an amount of 5 to 20 wt.%, photo-initiator, and optionally stabilizer, wt.% with respect to the amount of the whole composition. The invention also relates to a process of producing an elastomeric 3-dim article by processing the radiation-curable composition, an elastomeric 3-dim article obtainable by such a process.
B29C 64/129 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
B33Y 40/20 - Post-treatment, e.g. curing, coating or polishing
C08F 2/50 - Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light with sensitising agents
A method of using a negative pressure wound therapy dressing is provided. The method includes sealing a dressing to a tissue site. The dressing includes a silicone adhesive having a hydrophilic additive distributed therein. The method further includes reducing the pressure level at the tissue site using a negative pressure source that is in fluid communication with the dressing, in which the negative pressure source is either manually operated or battery operated.
A61F 13/0246 - Adhesive bandages or dressings characterised by the skin-adhering layer
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A method of preventing transmission of a virus from a mammalian subject. The method includes applying to a surface of the nasal cavity of the mammalian subject an aqueous composition. The aqueous composition includes a surfactant and a hydroxycarboxylic acid. The aqueous composition is at least substantially free of an antimicrobial agent. The aqueous composition has a viscosity of between 2,000 and 100,000 cps.
Medical dressings including stiffening systems fixedly attached to backing layers are described herein along with methods of using the medical dressings. The stiffening system is fixedly secured to the backing to limit flexing and stretching of the backing layer. Typically, the medical dressing and stiffening system is applied over a medical device that is secured to skin. The stiffening system covers some of the medical device and also extends beyond the medical device. The stiffening system stabilizes the medical device over the skin.
A method of making an adhesive article is described comprising: a) providing a mask between a layer of a polydiorganosiloxane composition and a source of radiant energy, wherein the mask comprises one or more openings that exposes a portion of the layer of polydiorganosiloxane composition covers a portion of the layer of polydiorganosiloxane composition; b) crosslinking the layer of the polydiorganosiloxane composition with radiation such that the portion of the layer of polydiorganosiloxane composition exposed through the one or more openings of the mask has greater crosslinking than the portion covered by the mask. In some embodiments, the mask is a mask substrate that is permanently bonded to the layer of polydiorganosiloxane after crosslinking. In other embodiments, the mask is a release liner mask that may be removed from the layer of polydiorganosiloxane after crosslinking. In yet other embodiments, the mask is a non-contact processing mask. Also described are adhesive articles, such as medical articles including medical tape, bandages, and wound dressing; and methods of use.
A method of making a (e.g. medical) adhesive article is described comprising: a) providing a layer of a polydiorganosiloxane composition on a (e.g. release liner) substrate wherein the layer has a first major surface proximate the substrate and an opposing second major surface; and b) exposing the opposing second major surface of the layer of the polydiorganosiloxane composition to radiation thereby curing the layer of the polydiorganosiloxane composition such that first major surface is a pressure sensitive adhesive and the opposing second major surface is a film backing. Adhesive (e.g. medical) articles and methods of use are also described.
A composition is described comprising polydiorganosiloxane; a silver material; and at least 1 wt.% of an oxygen-bearing metal filler of silicone, titanium, zirconium, or combination thereof. The crosslinked composition can have higher tensile strength than the same composition without the oxygen-bearing metal filler. In some embodiments, the polydiorganosiloxane comprises a nonfunctional polydiorganosiloxane. In another embodiment, a method of making an adhesive article is described comprising providing a layer of a polydiorganosiloxane composition on a (e.g. release liner) substrate wherein the layer comprises nonfunctionalized polydiorganosiloxane and a silver material; and exposing the layer of polydiorganosiloxane composition to radiation thereby crosslinking the layer of the polydiorganosiloxane composition.
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
The present disclosure is directed to self-contained biological indicators wherein a single type of indicator is capable of being used for various sterilization conditions, including sterilization with steam and/or ethylene oxide. In some embodiments, a single type of biological indicator is capable of being used for different steam sterilization conditions having varied temperatures and sterilization cycles.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
The disclosed tube securement device attaches to the patient's body and to the tube, while allowing for a section of the tube to be detached from the tube securement device. The tube securement device comprises a backing with adhesive coated sections. The backing comprises a first end section, a second end section, and a midsection, separating the first end section from the second end section. The tube securement device further comprises a first adhesive on at least a portion of the first major surface of the first end section, a second adhesive on at least a portion of the first major surface of the second end section, and wherein the first major surface of the midsection is free of tacky adhesive.
Adhesive (e.g. medical) articles are described comprising a layer of a crosslinked nonfunctionalized polydiorganosiloxane adhesive composition having a first major surface and second opposing major surface; and a porous substrate proximate the first major surface, proximate the second major surface, embedded within the polydiorganosiloxane adhesive layer, or a combination thereof. The porous substrate is a fibrous substrate or apertured organic polymer film. The apertures can be formed before or after application of the polydiorganosiloxane adhesive composition.
Pressure activated adhesive articles include a substrate, a pressure activated adhesive layer disposed on the substrate, and a hydrocarbon-based release liner. The pressure activated adhesive layer is a crosslinked adhesive composition, with a siloxane polymer that has been crosslinked, and at least one siloxane tackifying resin. The pressure activated adhesive is non-adhesive at room temperature having a Tg of at least 50°C as measured by DMA (Dynamic Mechanical Analysis), but upon application of pressure to the adhesive layer the adhesive layer adheres to a substrate.
1H-Imidazo[4,5-c]quinolin-4-amine compounds having a triazole ring substituent at the 1-5 position, salts thereof, conjugates thereof, pharmaceutical compositions containing the compounds and conjugates, and methods of making the compounds and conjugates are disclosed. Methods of using the compounds and conjugates as immune response modifiers for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases, including viral and neoplastic diseases, are also described.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A system comprising a dosing cylinder and a control valve have been disclosed. The dosing cylinder comprises a dosing port for ingress and egress of a fluid and a returnable dosing chamber piston. The control valve comprises a valve housing, a returnable valve piston, and a valve pressure port to create negative pressure inside the valve housing. On application of negative pressure, the valve piston moves towards a first terminal position to allow transfer of the fluid towards the dosing cylinder and dosing chamber piston moves towards a first extreme position to receive the fluid. On removal of negative pressure, the dosing chamber piston moves towards a second extreme position to push the fluid out of the dosing cylinder and the valve piston moves towards a second terminal position to allow transfer of the towards a wound site and restrict transfer of the fluid towards the dosing cylinder.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
F16K 11/07 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with linearly sliding closure members with cylindrical slides
F16K 31/122 - Operating meansReleasing devices actuated by fluid the fluid acting on a piston
A sterilization indicator reading apparatus includes a housing, at least one well formed from a portion of the housing and dimensioned to receive a sterilization indicator, at least one heating element thermally coupled to a coupling portion of the well, at least one sensor configured to sense at least one parameter associated with the sterilization indicator received within the well and generate response signals upon sensing the parameter, and a processor communicably coupled to the heating element and the sensor. The processor is configured to control the heating element to achieve a first preset temperature of the well from a first instance of time after receiving a first response signal from the sensor, and to control the heating element to achieve a second preset temperature of the well upon receiving a second response signal from the sensor, or after a predetermined time duration from the first instance of time.
An apparatus for treating a tissue site with negative pressure may include a first polymer film having a plurality of first perforations. A primary manifold may be adjacent to the first polymer film. The primary manifold may include a plurality of primary nodes and a plurality of links. The primary nodes and the links may be interconnected to define a grid of windows that are transparent. Further, a second polymer film may be adjacent to the primary manifold. The second polymer film may have a plurality of second perforations. The first polymer film and the second polymer film are bonded together in at least a center window of the primary manifold.
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
50.
Compression Bandage Systems with Areas of Increased Local Pressure
Bandages, compression bandage systems, and kits including the same are described. Further described methods for reducing or preventing swelling in an extremity with the use of bandages and compression bandage systems.
A system for generating a clinical note includes a processor configured to receive a transcript of a conversation that includes an ordered series of conversation segments. The processor is further configured to sequentially provide the ordered series of conversation segments to a first machine learning model and sequentially generate, via the first machine learning model, a partial note for each conversation segment, such that an ordered series of partial notes is generated. Each partial note includes a summary of the corresponding conversation segment and the one or more conversation segments preceding the corresponding conversation segment. The processor is further configured to determine a draft note as a last partial note, and generate, via a second machine learning model, a final clinical note by rewriting the draft note. The processor is further configured to output the final clinical note to at least one of a user interface and a computer-readable storage.
A securement device (100) for securing a lumen (12) of a medical device (14) includes a main body (110) configured to be detachably secured to a skin of a user. The main body includes a first body portion (112) including a first cavity surface (118) and a second body portion (142) including a second cavity surface (148) pivotally coupled to the first cavity surface. The first and second cavity surfaces together define a cavity (170). The securement device further includes an insert (180) fixedly coupled to the main body and at least partially received within the cavity. The insert includes a groove (184) configured to receive the lumen of the medical device. The main body is deformable between an open configuration and a closed configuration, and the insert is correspondingly deformable between a release state and a secure state. In the release state, the groove is configured to receive the lumen therein. In the secure state, the lumen is secured within the groove.
The invention relates to a composition comprising a resin matrix, an initiator system and a filler system. The resin matrix comprises a polymerizable component which contains a backbone comprising either a resorcinol or catechol moiety. The composition is in particular useful in the dental and orthodontic field, e.g. as dental filling material having advantageous properties.
The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprising
Si oxide calculated as SiO2 from 55 to 80 wt.-%,
Li oxide calculated as Li2O from 7 to 16 wt.-%,
Al oxide calculated as Al2O3 from 1 to 5 wt.-%, and
P oxide calculated as P2O5 from 1 to 5 wt.-%,
wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600° C.
The present invention is directed to a process for producing a sintered lithium disilicate glass ceramic dental restoration out of a porous 3-dim article, the process comprising the step of sintering the porous 3-dim article having the shape of a dental restoration with an outer and inner surface to obtain a sintered lithium disilicate ceramic dental restoration, the sintered lithium disilicate glass ceramic dental restoration comprising
Si oxide calculated as SiO2 from 55 to 80 wt.-%,
Li oxide calculated as Li2O from 7 to 16 wt.-%,
Al oxide calculated as Al2O3 from 1 to 5 wt.-%, and
P oxide calculated as P2O5 from 1 to 5 wt.-%,
wt.-% with respect to the weight of the dental restoration, the sintering being done under reduced atmospheric pressure conditions, the reduced atmospheric pressure conditions being applied at a temperature above 600° C.
The present invention is also directed to a kit of parts comprising a porous 3-dim article having the shape of a dental milling block and a respective instruction of use.
Systems and techniques for automatically determining when a first treatment (e.g., orthodontic treatment) is recommended prior to performing a second treatment (e.g., dental restorative treatment) are disclosed including receiving a three-dimensional (3D) representation of a patient's dentition with at least one of gums of the patient or one or more teeth of the patient, computing one or more oral care metrics based on the 3D representation of the patient's dentition, comparing the one or more oral care metrics with a respective target threshold, determining based on the comparison a requirement for orthodontic treatment prior to a dental restorative treatment of one or more target pre-restoration teeth, and generating, based on the determining, a rendering of one or more indications recommending orthodontic treatment for the patient prior to dental restorative treatment on the one or more target pre-restoration tooth.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
57.
ANTI-MICROBIAL ACTIVITY THROUGH A PROTECTIVE COATING ON MEDICAL ARTICLES
Medical articles include a tube prepared from a polymer composition containing one or more extractable components. At least a portion of the exterior surface of the tube contains an anti-microbial layer. A transparent vapor-deposited coating of a barrier polymer derived from at least one ethylenically unsaturated monomer covers the exterior surface of the tube. The barrier coating reduces the extraction of extractable component(s) from the tube, but permits the anti-microbial to pass through the barrier layer and provide anti-microbial activity on the barrier surface.
A computer system and method identifies topics in conversations, such as a conversation between a doctor and patient during a medical examination. The system and method generates, based on first text (such as a document corpus including previous clinical documentation), a plurality of sentence embeddings representing a plurality of semantic representations in a plurality of sentences in the training text. The system and method generate a classifier based on the second text, which includes a plurality of sections associated with a plurality of topics, and the plurality of sentence embeddings. The system and method generate, based on a sentence (such as a sentence in a doctor-patient conversation) and the classifier, an identifier of a topic to associate with the first sentence. The system and method may also insert the sentence into a section, associated with the identified topic, in a document (such as a clinical note).
The disclosed reinforced adhesive substrate includes a transparent, flexible, breathable backing with a reinforcing material having open areas to the substrate. The reinforcing material strengthen the breathable backing while maintaining transparency so that overall the substrate is transparent. A transparent adhesive substrate can allow the underlying surface to be visualized.
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 7/03 - Layered products characterised by the relation between layers Layered products characterised by the relative orientation of features between layers, or by the relative values of a measurable parameter between layers, i.e. products comprising layers having different physical, chemical or physicochemical properties Layered products characterised by the interconnection of layers with respect to the orientation of features
B32B 37/12 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by using adhesives
60.
STERILIZATION INDICATOR READING APPARATUS WITH A COLOR SENSOR
Aspects of the present disclosure relate to a reading apparatus that a well formed from a portion of a housing. The well dimensioned to receive at least a portion of a sterilization indicator having spores. The reading apparatus can also have a heating element thermally coupled to a portion of the well and an excitation source to excite the substance in the sterilization indicator. The reading apparatus can have a sterilization indicator activation circuit for detecting activation of the sterilization indicator. The excitation source is positioned such that light from the excitation source is directed into the well. A color sensor can be positioned adjacent the well to receive reflected light from the sterilization indicator.
The present disclosure provides a user interface and related methods for displaying the full treatment history of a patient undergoing orthodontic treatment.
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G16H 30/00 - ICT specially adapted for the handling or processing of medical images
62.
PHOTOPOLYMERIZABLE COMPOSITIONS INCLUDING UREA/ACRYLAMIDE FUNCTIONAL COMPONENT, ARTICLES AND METHODS
The present disclosure provides a photopolymerizable composition comprising at least one (meth)acrylate reactive diluent and a polymerization reaction product of components comprising a urea functional component or an acrylamide functional component. The present disclosure also provides an orthodontic article and methods of making the orthodontic article. The method includes obtaining a photopolymerizable composition and selectively curing the photopolymerizable composition to form an orthodontic article. Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an orthodontic article; and generating, with the manufacturing device by an additive manufacturing process, the orthodontic article based on the digital object. A dental restorative tool or mold comprising a polymerized reaction product of a photopolymerizable composition is also provided.
A61K 6/887 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
B33Y 70/00 - Materials specially adapted for additive manufacturing
B33Y 80/00 - Products made by additive manufacturing
C08F 220/58 - Amides containing oxygen in addition to the carbonamido oxygen
Dental compositions having an organofluoride salt and a calcium silicate-containing cement are described. Methods for preventing demineralization of a tooth surface by way of releasing calcium ions, hydroxyl ions, and fluoride ions from said dental compositions are also described.
The disclosed adhesive eyelid closure article has a support layer and a pressure sensitive adhesive on the support layer. The support layer defines a main body and a non-adhesive tab area. The support layer has a central portion and an outer circumferential portion. The non-adhesive tab area is delimited by two recesses located in the outer circumferential portion of the support layer. The support layer has a first major surface and a second major surface opposite to the first major surface. The pressure sensitive adhesive is on at least part of the outer circumferential portion of the first major surface of the support layer, forming an adhesive coated area of the support layer.
The invention relates to a composition for isolating tissue, the composition comprising a radiation curable component A1, preferably being present in an amount of at least 40 wt. % with respect to the composition, the radiation curable component A1 comprising a polyether polyol spacer group having a molecular weight (Mw) of 1,000 to 20,000 g/mol, and at least two (meth)acrylate moieties, photo-initiator, guanidyl containing polymer, carrageenan, optionally softener, optionally dye, optionally filler, optionally additives. The invention also relates to a process for temporarily isolating tissue, the process comprising the steps of providing the composition described in any of the preceding claims, placing the composition in contact with tissue, radiation curing the composition at least partially for a time period T1, optionally moving or adjusting the partially cured composition, optionally radiation curing the partially cured composition for a time period T2, wherein T2>T1, removing the composition from the tissue.
A method for generating clinical notes includes receiving a plurality of existing clinical notes of a plurality of existing physicians and a plurality of audio records of conversations between the plurality of existing physicians and respective patients. The method further includes training a machine learning model using each of the plurality of existing clinical notes and the corresponding audio record. The method further includes receiving a prior clinical note of a new physician and selecting a representative physician from the plurality of existing physicians based on the prior clinical note and the plurality of existing clinical notes. The method further includes receiving an audio information of a new conversation between the new physician and a patient and generating, by the machine learning model, a personalized new clinical note of the new physician based on the new conversation and the one or more existing clinical notes of the representative physician.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
A catheter securement device (100) for use with a catheter assembly (10) includes abase (110) configured to be removably secured to a skin (20) of a user (22), a plurality of lock tabs (140) fixedly attached to the base (110) and extending from a first major surface (112) of the base (110), and a housing (160) configured to be placed on the first major surface (112) of the base (110). The housing (160) and the first major surface (112) of the base (110) at least partially enclose the catheter assembly (10) there-between. The housing (160) includes a plurality of lock handles (162). Each lock handle (162) from the plurality of lock handles (162) defines an aperture (164) therethrough. Each lock tab (140) is configured to be received through the aperture (164) of a corresponding lock handle (162) from the plurality of lock handles (164). Furthermore, each lock tab (140) is configured to be detachably attached to the first major surface (112) of the base (110), such that the housing (160) is removably secured to the base (110).
Described herein is a method. The method includes providing a filtration medium comprising a functionalized microporous membrane, wherein the functionalized microporous membrane comprises a plurality of guanidyl groups; contacting a biological fluid comprising a target with the filtration medium, wherein the biological fluid has a pH equal to or greater than an isoelectric point of the target; and eluting the target from the filtration medium with a second fluid to obtain a target solution, wherein the second fluid has a pH less than the pH of the biological fluid and less than an isoelectric point of the target.
Systems and methods for mapping wound features of a wound bed and also detecting degradation of electrode or connectivity performances are provided. Electrical measurements are collected from an array of electrodes which apply electrical signals to a periwound tissue outside the wound bed. The electrical measurements are processed to generate an impedance map of the wound bed, which is converted to maps conveying spatial distributions of clinical metrics.
A method. The method includes making a wound dressing, the method comprising: mixing dry collagen, oxidized regenerated cellulose (ORC) and melt bonding fibers to form a mixture; and heating the mixture.
A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g. sealant) composition for application to a tooth structure.
An apparatus for promoting circulation through a subcutaneous lymph vascular network may comprise a first manifold layer, a second manifold layer coupled to the first manifold layer, and a cover layer coupled to the second manifold layer. The first manifold may have a first stiffness, and the second manifold may have a second stiffness greater than the first stiffness. In some embodiments, the apparatus may additionally have a fluid interface configured to fluidly couple at least one of the first manifold layer and the second manifold layer to a fluid conductor through the cover layer. The fluid conductor may be coupled to or configured to be coupled to a source of negative pressure.
A61F 13/05 - Bandages or dressingsAbsorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
Metal-coated zirconia articles have at least one surface that is a surface-treated surface. The surface-treated surface is a phosphate-treated surface. At least a portion of the surface-treated surface is covered with a layer of metal. The metal covering adheres more strongly to the surface-treated surface than to an identical surface that is not surface-treated.
The disclosed sealing film is for surrounding a device for tamper evident protection of the contained device. The scaling film has a backing with a perimeter surrounding a central area and an adhesive on the backing at least at the perimeter of the backing. A tamper evident layer is separably connected to the backing along a substantial portion of the perimeter of the backing. Therefore, attempted peeling, pulling, opening of the sealing film will cause the tamper evident layer to remove from the backing and indicate tampering.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
Dental crowns having securing protrusions, methods of preparing said dental crowns, and methods of repairing a tooth with said dental crowns are described.
The disclosed sealing film is for surrounding a device for tamper evident protection of the contained device. The scaling film has a backing with a perimeter surrounding a central area and an adhesive on the backing at least at the perimeter of the backing. A substantial portion of the perimeter of the backing has an area of weakness. Therefore, attempted peeling, pulling, opening of the scaling film at the perimeter will cause tearing of the sealing film and indicate tampering.
A61M 5/50 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Computer hardware and software for reporting and clinical documentation of patient medical information. (1) Software as a Service (SaaS) services featuring software for recording, reporting, managing, and editing clinical documentation of patient medical information, and constructing workflows and producing analytics related thereto.
A catheter attachment system includes an adhesive attachment layer and a polymeric hardgood article 100 for holding the catheter. The polymeric hardgood is a hinged article that contains two interlocking members. The first member is a holding member 120 with a securement surface designed to hold the hub of a catheter. The securement surface is a conformable layer that has a high coefficient of friction with a value of 0.5 or higher. The second member 130 is a cover member hingably linked to the holding member, where the cover member is designed to contact at least a portion of the securement surface of the holding member when closed, to hold the hub of a catheter.
An article and a method of making the article. The article can include a conformable matrix comprising a mixture of collagen, bioactive glass, and an additive selected from cellulose and/or alginate; wherein the article is a conformable wound dressing. Methods of making articles and methods of using articles to treat wounds are described.
A61L 15/32 - Proteins, polypeptidesDegradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
A61L 15/18 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
A61L 15/42 - Use of materials characterised by their function or physical properties
80.
DENTAL ARTICLE WITH APPLICATION DEVICE, LUBRICANT COMPOSITION AND DENTAL MATERIAL
The invention relates to a dental article (10) comprising an application device (20) with a compartment (30) having an inner surface (31) with a structured surface area comprising recesses (32), a piston assembly (40) moveably located in the compartment (30), the piston assembly comprising a piston body (41), a dispensing section (50) located at the distal end of the compartment, a lubricant composition (60) located at least in the recesses of the structured surface area (32), a dental material (70) being located in the compartment in contact with the lubricant composition (60).
A dental composition is provided. The dental composition includes at least one monomer comprising at least two ethylenically unsaturated groups; and an addition-fragmentation agent comprising at least one cyclic imide monomer comprising an α, β-unsaturated carbonyl.
A liquid applicator for applying a liquid to a surface. The applicator includes a hollow body comprising a wall defining an internal chamber having a closed end and an open end. The applicator further includes a felted polyurethane foam coupled to the open end of the hollow body and an alcohol-based antiseptic solution dispersed within the polyurethane foam. The polyurethane foam has a flatwise tensile strength of at least 1.0 lbf*in/(in2 of foam).
A method of sterilizing an antiseptic solution and an interior of a sealed container in which the antiseptic composition is contained. The method includes adding an antiseptic solution into the container and then sealing the container to form a sealed container having interior walls that define an interior volume. The method further includes wetting the interior walls of the container with the antiseptic solution. The method further includes subjecting the sealed container to heat at a predetermined sterilization temperature of from 50 to 80 degrees Celsius for a predetermined sterilization time of from 50 to 500 minutes.
A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.
A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.
A method of suppressing microbial virulence. The method includes administering and/or applying a composition. The composition includes (a) a surfactant comprising (i) a polyethylene glycol compound comprising a fatty acid moiety, or (ii) a fatty acid containing compound. The composition further includes (b) (i) a phosphate containing compound, and (ii) a metal salt; and (c) an aqueous carrier. The surfactant is present in an amount of between 0.01 wt. % and 1 wt. %, based on the total weight of the composition.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Techniques for detecting leaks in negative pressure wound therapy (NPWT) systems are described. According to an example of the present subject matter, a frequency spectrum of sound emanating from a NPWT system is analysed to determine whether the frequency spectrum comprises frequencies in a predetermined range of frequencies corresponding to leakage of fluid from the NPWT system. Based on presence of frequencies corresponding to the predetermined range of frequencies a leak in the NPWT system may be identified.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
88.
CUSTOMIZED ZIRCONIA GEL ARTICLE, ZIRCONIA DENTAL RESTORATION AND PROCESS OF PRODUCTION
The invention relates to a customized zirconia gel article having the shape of a dental restoration, the customized zirconia gel article comprising a transition area comprising a transition gel, the transition area having a color gradient, the material composition of the transition gel comprising crystalline zirconia particles, a crystal phase stabilizer component, a cured organic component, optionally a photo-initiator, a liquid, and a coloring component, wherein the crystal phase stabilizer component is contained in the crystalline zirconia particles and the optional coloring component can be contained in the crystalline zirconia particles or be present as a separate component in the gel. Further, the invention relates to a process for producing such a customized zirconia gel article.
Packaged adhesive compositions include a thermoplastic packaging material and a pressure sensitive adhesive composition contained within the packaging material. The pressure sensitive adhesive composition is an adiabatically polymerized composition prepared from a reaction mixture of an alkyl(meth)acrylate monomer, a reinforcing monomer, a photocrosslinkable monomer, and at least one initiator. The packaged adhesive composition is hot melt processable to form a pressure sensitive adhesive layer. The hot melt processed packaged adhesive composition has a higher 180° Peel Force and a higher Shear Holding Power than the same hot melt processed adhesive that has not been packaged.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Software as a Service (SaaS) services featuring software for recording, reporting, managing, and editing clinical documentation of patient medical information, and constructing workflows and producing analytics related thereto
91.
Geometric Deep Learning for Setups and Staging in Clear Tray Aligners
Systems and techniques are described for training and using a generative adversarial network (GAN) to produce intermediate stages and final setups for clear tray aligners (CTAs) including receiving, by one or more computer processors, a first digital representation of a patient's teeth, using, by the one or more computer processors and to determine a prediction for one or more tooth movements, a generator that is a neural network included in a GAN and that has been trained to predict one or more tooth movements, and producing, by the one or more processors, an output state that includes at least one of a final setup and one or more intermediate stages.
A61C 7/00 - Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
92.
Orthodontic Articles and Methods of Making and Postprocessing Same
The present disclosure provides a method of making an orthodontic article. The method includes (a) providing a photopolymerizable composition; (b) selectively curing the photopolymerizable composition using actinic radiation to form an article in the shape of an orthodontic article including a number of layers of at least one photopolymerized polymer; and (c) moving the article and thereby generating a mass inertial force in the uncured photopolymerizable composition. The article has a first surface, and no more than 75% of the first surface has a slope magnitude greater than 2.5 degrees. Orthodontic articles are also provided, including an orthodontic article that is prepared according to the method. Orthodontic articles having low extractable component content are further provided. The mass inertial force tends to form a coating layer of uncured photopolymerizable composition on the article, and curing the coating layer can form a surface having low slope magnitude. The low slope magnitude may be correlated to a low haze of the surface of the article.
B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
A method of processing polynucleic acids is described comprising: providing a solid support comprising ligands with an amide group: exposing the solid support to polynucleic acid molecules in a buffer having a pH less than 5.5 to bind at least a portion of the polynucleic acid molecules to the ligands: c) exposing the solid support (e.g. particles) with bound polynucleic acid molecules to a buffer having a pH greater than 6 to release a portion of the bound polynucleic acid molecules from the ligands of the particles and to retain a portion of the polynucleic acid molecules bound to the solid support (e.g. particles); and utilizing the solid support with retained bound polynucleic acid molecules or suspension thereof.
A device for providing a dental material, which comprises a compartment formed by first and second interconnected layers, and a well adjacent the compartment in the first layer. The second layer partially overlaps the well. The device includes a compartment for receipt of an applicator and a compliant mechanism in the compartment to articulate the device along a fold line. The device helps the dental material to be used in a convenient manner, and may be relatively inexpensive to manufacture.
A61C 5/60 - Devices specially adapted for pressing or mixing capping or filling materials, e.g. amalgam presses
A61C 5/68 - Mixing dental material components for immediate application to a site to be restored, e.g. a tooth cavity
A61C 19/02 - Protective casings, e.g. boxes for instrumentsBags
B65D 75/32 - Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
B65D 75/58 - Opening or contents-removing devices added or incorporated during package manufacture
B65D 77/24 - Inserts or accessories added or incorporated during filling of containers
B65D 81/32 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
95.
A FLUORESCENT ENZYME SUBSTRATE AND METHODS OF USING THE SAME
Described herein is a β-glycoside of the structural formula (I) wherein X1 or X2 is -C(=O)OR, R is an alkyl group comprising 1 to 6 (1-4) carbon atoms, and Y is a monovalent sugar selected from β-D-glucose, β-D-galactose, β-D-glucuronic acid, N-acetylglucosamine, or galactosamine, wherein when X1 is -C(=O)OR, then X2 is - H and when X2 is -C(=O)OR then X1 is -H. Such β-glycosides may be used as indicators, for example biological indicators.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
A61L 2/28 - Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
Water filtration and purification units and replacement
cartridges and filters therefor; water filters and
components thereof, namely, filter cartridges for reduction
of hard water, acid water, iron, lead, dirt, rust and
sediment from drinking water supplies, hot water systems,
and household appliances and humidifiers, for domestic and
industrial use; water sterilizers; water softening
apparatus; water filtration systems comprised of a filter
cartridge, tubing, connectors and brackets; reverse osmosis
water purification system.
The present invention relates to a custom tool (10) for forming a dental restoration in a mouth of a patient, the custom tool comprising a mold body (12) providing for a customized fit with at least one tooth (102) of the patient, the mold body (12) including an occlusal portion forming an occlusal surface (32) corresponding with an occlusal surface of the tooth (102) or an incisal portion corresponding with an incisal surface of the tooth, a mesial proximal portion forming a mesial proximal surface (31) corresponding with a mesial proximal surface of the tooth (102), and a distal proximal portion forming a distal proximal surface (35) corresponding with a distal proximal surface of the tooth (102), wherein the mold body (12) is configured to combine with the tooth (102) of the patient to form a mold cavity encompassing missing tooth structure of the tooth (102), and wherein the occlusal or incisal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient, wherein the mold body (12) contains features configured to extend subgingivally or into a hidden interproximal space.
A dressing system for sensing a presence of an analyte includes a first layer, and a second layer facing a first major surface of the first layer. The second layer has a second permeability to the analyte less than a first permeability of the first layer. The dressing system further includes a first fiber configured to deliver an excitation light. The dressing system further includes at least one sensor layer including a sensor material configured to receive the excitation light from the first fiber and emit an emitted light in response to the excitation light. The dressing system further includes a second fiber separate from the first fiber and configured to receive the emitted light from the at least one sensor layer.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
99.
Two-Part Dental Sealant, Method of Applying with a Syringe Device, and Kit
A method of applying a two-part dental sealant is described comprising providing a syringe device comprising a cartridge including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle comprising a static mixer and an outlet at one end of the cartridge and a plunger at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.
The invention relates to a dental article comprising an application device (20) with a compartment (30) having an inner surface (31), a piston assembly (40) moveably located in the compartment (30), the piston assembly comprising a piston body (41), a seal A (42) at the front end of the piston body, seal A having one or more gaps (43), a seal B (44) spaced apart from seal A, a collection reservoir (45) suitable for collecting a lubricant composition during the dispensing of a dental material, a dispensing section (50) located at the distal end of the compartment, a lubricant composition (60) located on the inner surface of the compartment, and a dental material (70) being located in the compartment in contact with the lubricant composition.
