Abstract

There is provided a sperm extender medium for prolonging the fertility of bovine spermatozoa during liquid storage of the spermatozoa. The medium comprises a monosaccharide energy source for the spermatozoa. The one or more ? or ? amino acid osmolytes are selected from mono-amino carboxylic and mono-amino sulfonic acids, each independently having an R side group selected from the group consisting of H and non-polar, neutral open aliphatic chains excluding branched C3 and longer aliphatic chains. The medium also comprises one or more antioxidants and physiologically acceptable inorganic salts for maintaining sperm viability, and is buffered for maintaining pH in a range of from about 7.0 to about 8.5. Further, in embodiments, the medium has a concentration of sodium ions of less than about 95 mM, and an osmolarity in a range of from about 290 mOsm/L to about 400 mOsm/L. There are also provided preparations comprising the spermatozoa in the medium, methods for preparing the medium and methods for fertilisation of an ovum comprising contacting the ovum with spermatozoa administered in the sperm extender medium.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 35/52 - SpermProstateSeminal fluidLeydig cells of testes
• A61K 47/02 - Inorganic compounds
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• C12N 5/076 - Sperm cellsSpermatogonia

Abstract

Provided herein is a transdermal liquid formulation that includes a propionic acid-based non-steroidal anti-inflammatory agent, such as ketoprofen, and a dermal penetration enhancer containing an alcohol, an emollient and an essential oil. Methods of using and making the aforementioned transdermal liquid formulation are also provided herein.

IPC Classes  ?

• A61K 9/08 - Solutions
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to a method of reducing total gas production and/or methane production in a ruminant animal.

IPC Classes  ?

• A61K 36/04 - Rhodophycota or rhodophyta (red algae), e.g. Porphyra
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system

Abstract

The present disclosure teaches generally in the field of vaccination and
disease control in cattle and bovine animals.
A recombinant bovine herpesvirus 1 (BoHV-1) vaccine vector is provided for
efficient control of one or more bovine pathogens
such as those associated with bovine respiratory disease complex, such as
bovine viral diarrhoea virus (BVDV), and which ameliorates
disease conditions caused thereby. Protocols for the management of confined or
herded bovine animals are also enabled herein.

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• A61K 39/102 - PasteurellaHaemophilus
• A61K 39/112 - SalmonellaShigella
• A61K 39/12 - Viral antigens
• C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
• C12N 15/40 - Proteins from RNA viruses, e.g. flaviviruses
• C12N 15/869 - Herpesviral vectors