Abstract

The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention relates to novel caging-group-free photoactivatable fluorescent dyes having the structural formula I: as well as to the corresponding photoactivated fluorescent dyes having the structural formula II: The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.

IPC Classes  ?

• C09B 57/00 - Other synthetic dyes of known constitution
• C09B 6/00 - Anthracene dyes not provided for above
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Method for automatic focusing and astigmatism correction for a specific microscope setup, in particular an electron microscope, the microscope being at least adjustable in microscope parameters a working distance, a stigmator in a x-direction and a stigmator in a y-direction, the method comprising the steps: a) capturing a first image of a sample with a first working distance perturbation and capturing a second image of the sample with a second working distance perturbation around a current working distance and current stigmator settings; b) selecting n subareas of the first image and n subareas of the second image, n≥1, wherein an i-th subarea of the first image and an i-th subarea of the second image form an i-th input patch pair, 1≤i≤n; c) processing each i-th input patch pair and receiving an i-th correction term comprising a correction to the current working distance, stigmator in x-direction and stigmator in y-direction; d) receiving an output correction term as a function of all the correction terms; e) adjusting the current working distance and stigmator settings by applying the output correction term to the current working distance and stigmator settings.

IPC Classes  ?

• H01J 37/21 - Means for adjusting the focus
• H01J 37/153 - Electron-optical or ion-optical arrangements for the correction of image defects, e.g. stigmators

Abstract

Provided are a method and a device for characterizing a resonator element, a method and a device for providing an optical frequency reference, a LIDAR system and a gas sensing system. The method includes coupling a laser light into the resonator element, the resonator element having multiple carrier resonances for the carrier frequency of the laser light.

IPC Classes  ?

• G01M 11/02 - Testing optical properties

Abstract

The invention relates to a source arrangement (10) for a TLE system (100) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by a laser beam (112), comprising a support (20) carrying said source element. Further, the invention relates to a TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14). In addition, the invention relates to a method for using a TLE system (100), the TLE system (100) comprising a laser source (110) for providing a laser beam (112), a reaction chamber (120) for containing a reaction atmosphere (124), a source arrangement (10) for providing a source element (12) comprising or consisting of a source material (14) to be evaporated and/or sublimated by the laser beam (112) within the reaction chamber (120), and a substrate arrangement (130) for providing a substrate (132) to be coated within the reaction chamber (120) with the evaporated and/or sublimated source material (14).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

The present disclosure relates to compounds that bind to the kelch domain-containing protein 2 (KLHDC2) E3 ligase active site and heterobifunctional targeted protein degraders comprising the compounds. Methods of using these degraders in the treatment of cancer is also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

IPC Classes  ?

• C07D 495/14 - Ortho-condensed systems
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 471/04 - Ortho-condensed systems
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

Connectomes of human cortical gray matter require high-contrast homogeneously stained samples sized at least 2-3 mm on a side, and a whole-mouse brain connectome requires samples sized at least 5-10 mm on a side. Here, en-bloc staining and postprocessing protocols are reported, including dehydrating and embedding of neuronal samples, for dense neuronal circuit reconstruction and other applications.

IPC Classes  ?

• G01N 1/30 - StainingImpregnating
• G01N 23/2251 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by measuring secondary emission from the material using electron or ion microprobes using incident electron beams, e.g. scanning electron microscopy [SEM]

Abstract

The present invention relates to compounds, compositions and kits suitable to precise genome editing efficiency in a eukaryotic target organism.

IPC Classes  ?

• C12N 15/90 - Stable introduction of foreign DNA into chromosome
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Abstract

The current disclosure relates to methods for treating ovarian cancer based on specific antigen expression of the cancer. Furthermore, the expressed antigen may be used in immunotherapeutic methods for treatment of the ovarian cancer. Aspects of the disclosure relate to immunotherapies targeting CT45 polypeptides, methods for treating ovarian cancer based on CT45 expression, and kits for detecting CT45 polypeptides and nucleotides.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
• A61K 31/555 - Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
• A61K 31/706 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
• A61K 33/243 - PlatinumCompounds thereof
• A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
• A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• A61K 38/20 - Interleukins
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/42 - Cancer antigens
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

The present invention relates to a polypeptide with at least 85% sequence identity to SEQ ID NO: 1, as an endo-β-1,4-xylanase (EC 3.2.1.8) having transglycosylation activity. Preferably, said polypeptide is obtained from Rhamnusium bicolor. In another aspect, the present invention refers to a polynucleotide encoding said polypeptide, a preparation method of said polypeptide, use of said polypeptide for producing xylose oligosaccharides by transglycosylation reaction, and a producing method of xylose oligosaccharides by using said polypeptide. Furthermore, the present invention is directed to a mixture of xylose oligosaccharides obtainable by the producing method by using said polypeptide, and use of the mixture of said xylose oligosaccharides in life science, in particular, as prebiotics, nutraceuticals, pharmaceutically active ingredients, or food supplements.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
• C12P 19/02 - Monosaccharides

Abstract

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic hydrogenation of CO2 to methanol. The catalytically active material comprising a metal oxide doped with a doping metal, wherein the metal oxide is selected from CeO2, ZnO, Ga2O3, In2O3, ZrO2, Fe2O3 and Al2O3, the doping metal is selected from Cu, Rd and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment.

IPC Classes  ?

• B01J 23/89 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with noble metals
• B01J 35/45 - Nanoparticles
• B01J 35/58 - Fabrics or filaments
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/08 - Heat treatment
• B01J 37/12 - Oxidising
• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• C07C 1/12 - Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of carbon from carbon dioxide with hydrogen

Abstract

The invention relates to nanofilament-coated membranes with hierarchical porous structures comprising a microporous polymer support membrane having through-going pores with a nominal pore diameter in the range from 0.2 μm to 50 μm and a superhydrophobic fluorine-free nanoporous layer having through-going pores with a nominal pore diameter in the range from 5 nm to 200 nm provided on said support membrane and comprising or consisting of a porous network of polysiloxane nanofilaments. In more specific embodiments of said nanofilament-coated porous membranes, the microporous support membrane comprises or consists of a polymer which is selected from the group consisting of polyethersulfone (PES), cellulose acetate (CA), polypropylene (PP), polyamide (nylon), polytetrafluoroethylene (PTFE), polyvinyl difluoride (PVDF) or polyethylene (PE). A second aspect of the invention relates to the use of these nanofilament-coated porous membranes for membrane distillation, in particular in a process of desalination of saline or distillation of contaminated water or extraction of water from waste water or extraction of other volatile components from a feed solution and to a device, in particular a membrane distillation device, comprising these nanofilament-coated porous membranes. A further aspect of the invention relates to a method for preparing these nanofilament-coated porous membranes.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 61/36 - PervaporationMembrane distillationLiquid permeation
• B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
• B01D 69/10 - Supported membranesMembrane supports
• B01D 71/70 - Polymers having silicon in the main chain, with or without sulfur, nitrogen, oxygen or carbon only
• C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis

Abstract

The present invention refers to a coating apparatus for coating a substrate of a substrate material with at least one material layer of a layer material, said coating apparatus comprising a process chamber having a process volume for receiving a substrate holder for arranging the substrate, wherein the substrate holder is arranged in a fixed position in the process volume such that the substrate holder can furthermore be provided rotatable and/or movable essentially in a plane normal to the deposition direction as a whole, wherein the process chamber has a chamber wall for at least substantially completely enclosing the process volume; a gas system connected in a fluid-communicating manner to the process volume for generating a coating atmosphere in the process volume; and a source holder arranged in the process volume and providing at least one source material.

IPC Classes  ?

• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation
• C23C 16/40 - Oxides
• C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber

Abstract

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic oxidation of CO to CO2 or in the catalytic hydrogenation of alkyne. The catalytically active material comprises a support5 comprising a metal oxide, and atomically dispersed noble metal on the surface of the support, wherein the metal oxide is selected from TiO2, CeO2, ZnO, SnO2, Ga2O3, In2O3, ZrO2, and Fe2O3, the noble metal is selected from Pt, Pd, Rh, and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment in the presence of O2.

IPC Classes  ?

• B01J 37/34 - Irradiation by, or application of, electric, magnetic or wave energy, e.g. ultrasonic waves
• B01J 23/63 - Platinum group metals with rare earths or actinides
• B01J 35/45 - Nanoparticles
• B01J 37/02 - Impregnation, coating or precipitation
• B01J 37/03 - PrecipitationCo-precipitation
• B01J 37/08 - Heat treatment
• C01B 32/50 - Carbon dioxide
• C07C 5/08 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of carbon-to-carbon triple bonds

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby evaporating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby evaporating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The invention is related to a method of using a thermal laser evaporation (TLE) system (100), the system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source (30) comprising a source material (32), and a laser source (50) for providing laser radiation (52) at a surface (34) of the source (30) and thereby sublimating the source material (32). Further, the invention is related to a thermal laser evaporation system (100) comprising a reaction chamber (10) fillable with a reaction atmosphere (14), one or more sources (30) arranged in the reaction chamber (10), each source comprising a source material (32), and coupling means (12) provided by the reaction chamber (10) for coupling laser radiation (52) into the reaction chamber (10) for impinging on a surface (34) of the source (30) and thereby sublimating the source material (32).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/064 - Shaping the laser beam, e.g. by masks or multi-focusing by means of optical elements, e.g. lenses, mirrors or prisms
• B23K 26/067 - Dividing the beam into multiple beams, e.g. multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/08 - Devices involving relative movement between laser beam and workpiece
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• B23K 26/362 - Laser etching

Abstract

The present invention relates to a method for the generation of outer radial glial (oRG) cells of the outer sub-ventricular (oSVZ)-like region in cerebral organoids comprising (a) culturing primate stem cells in a primate stem cell medium until about day 6, thereby inducing the formation of embryonic bodies; (b) culturing the embryonic bodies as obtained in step (a) in a neural induction medium until about day 11, thereby inducing the formation of organoids; wherein an inhibitor of TGF-β, an inhibitor of BMP and an inhibitor of WNT is present from about day 2 until about day 11; (c) embedding the organoids as obtained after steps (a) and (b) and if they display a size of at least 300 μm into a hydrogel that mimics the extracellular matrix (ECM), preferably Matrigel and culturing the organoids in a cerebral differentiation medium at least until about day 40, preferably at least until about day 60 and most preferably at least until about day 80, thereby obtaining cerebral organoids with oRG cells in oSVZ-like regions, wherein the organoids in step (c) are subjected to agitation from about day 15 onward, preferably by using an orbital shaker or a spinning bioreactor; and (d) optionally isolating one or more oRG cells from the oSVZ-like region.

IPC Classes  ?

• C12N 5/079 - Neural cells
• C12N 5/0793 - Neurons

Abstract

A method of scattering-type scanning near-field optical microscopy (s-SNOM) comprises placing an s-SNOM tip 11 at a near-field distance from a sample 1 and subjecting the s-SNOM tip 11 to a mechanical oscillation, which provides a primary modulation, illuminating the oscillating s-SNOM tip 11 with a sequence of illumination light pulses, wherein each of the illumination light pulses hits the s-SNOM tip 11 at a specific s-SNOM tip modulation phase φi of the mechanical oscillation, collecting scattering light pulse amplitudes Si, each being created by scattering one of the illumination light pulses at the s-SNOM tip 11, using a scattering light detector device 30, collecting the s-SNOM tip modulation phase i associated to each of the collected scattering light pulse amplitudes Si, using a mechanical oscillation detector device 40, and calculating an s-SNOM near-field signal by demodulating a scattering light function S(φi) of the scattering light pulse amplitudes Si in dependency on the s-SNOM tip modulation phases φi, wherein each of the s-SNOM tip modulation phases pi is obtained by splitting an output signal of the mechanical oscillation detector device 40 into a first output signal portion X and a second output signal portion Y being phaseshifted relative to the first output signal portion X and calculating the s-SNOM tip modulation phase φi of the primary modulation from the first and second output signal portions X, Y. Furthermore, a scanning near-field optical microscopy apparatus 100 is described.

IPC Classes  ?

• G01Q 60/18 - SNOM [Scanning Near-Field Optical Microscopy] or apparatus therefor, e.g. SNOM probes

Abstract

The present invention relates to a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102), the temperature control system (10) comprising conduits (20) which can be thermally coupled to a chamber wall (110) of the vacuum chamber (102), a fluid pump (50), temperature adjusting means (30) comprising a heating means (32) or both a heating means (32) and a cooling means (34), and tubing (52) for fluidly connecting said conduits (20), fluid pump (50), and temperature adjusting means (30), respectively. Further, the present invention relates to a vacuum system (100) with a vacuum chamber (102), the vacuum chamber (102) comprising a chamber wall (110) enclosing a vacuum volume (106), a vacuum pump system (104) connected to the vacuum chamber (102) for evacuating the vacuum volume (106), and a temperature control system (10) for adjusting a temperature (60) of a vacuum chamber (102). In addition, the present invention relates to a method of adjusting the temperature (60) of a vacuum chamber (102) of said vacuum system (100).

IPC Classes  ?

• C23C 14/54 - Controlling or regulating the coating process
• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation

Abstract

The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) The present invention relates to a compound of general formula (I) or an enantiomer, diastereomer, stereoisomer, which mediates resistance against leaf- and planthopper pests. The present invention further relates to a method of producing the compound, an enzymatic production method the compound using at least a BBL2 polypeptide, as well as a PPO, AT1, ODC, HPL, PAL, C4H, 4CL, HCT and/or C3H activity. Further envisaged are genetically modified organisms producing the compound, expression cassettes for heterologous expression of the activities, the use of corresponding polypeptides and polynucleotides for the production of the compound, a composition including the compound, as well as uses of the compound for plant protection.

IPC Classes  ?

• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• A01N 37/42 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing within the same carbon skeleton a carboxylic group or a thio-analogue, or a derivative thereof, and a carbon atom having only two bonds to hetero atoms with at the most one bond to halogen, e.g. keto-carboxylic acids
• A01P 15/00 - Biocides for specific purposes not provided for in groups
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/04 - Oxidoreductases (1.), e.g. luciferase acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
• C12N 9/10 - Transferases (2.)
• C12N 9/88 - Lyases (4.)
• C12P 13/02 - Amides, e.g. chloramphenicol

Abstract

Disclosed is an optical fiber feedthrough (10) configured to feed through optical fibers (1) between an interior and exterior of evacuable vacuum chamber (30). The feedthrough includes at least one mounting flange (11a, 11b) configured for pressure-tight fastening to vacuum chamber and includes passage openings (12a, 12b) configured for pressure-tightly receiving a respective optical fiber. The passage openings are each provided with a sealing receptacle (13a, 13b) and a sealing element (14a, 14b) arranged therein for pressure-tightly receiving the respective optical fiber. A compression device (15a, 15b) is connected to each mounting flange, which is configured to compress the respective sealing elements axially along the respective passage openings. Also disclosed is an optical fiber assembly (20) including the feedthrough and optical fibers, and a method for passing a plurality of optical fibers between an interior and exterior of an evacuable vacuum chamber using the aforementioned feedthrough.

IPC Classes  ?

• G02B 6/44 - Mechanical structures for providing tensile strength and external protection for fibres, e.g. optical transmission cables

Abstract

An apparatus for determining an arrhythmia of a living heart comprises a signal evaluation device receiving a signal representing a present electric activity of the heart, and determining a frequency spectrum of the signal. The apparatus further comprises a pulse generator generating a sequence of electric pulses to be applied to the heart at a pulse repetition frequency that depends on the frequency spectrum and decreases by at least 20% over the sequence.

IPC Classes  ?

• A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
• A61N 1/37 - MonitoringProtecting
• A61N 1/39 - Heart defibrillators

Abstract

In order to map the surface of a macromolecule, at least one fluorescent probe is introduced into a medium in which the macromolecule is embedded or will be embedded. Then, a plurality of spatial positions of the at least one fluorescent probe with regard to the macromolecule are determined via localization of the at least one singularized fluorescent probe with a simple standard deviation of no more than 2 nm. For this purpose, fluorescence light photons emitted by the singularized fluorescent probe are recorded. In addition, a bounding surface bounding the determined spatial positions with regard to the macromolecule is determined; and a three-dimensional map of at least a part of the surface of the macromolecule is generated from the bounding surface.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1429 - Signal processing
• G01N 15/1434 - Optical arrangements

Abstract

According to a method of manufacturing a magnetic memory device, various types of magnetic memory devices can be manufactured at low cost by manufacturing a plurality of magnetic modules by using a delamination phenomenon of pattern segments and stacking the plurality of magnetic modules to complete a stacked memory device.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices

Abstract

The invention relates to a safety apparatus (100) for monitoring a light path of a laser beam (1) and for interrupting the laser beam (1) in response to an object (2) approaching the laser beam (1), said apparatus comprising: at least one light barrier device (200) having a light source device (210) arranged to generate a safety light field (3) that extends along at least one longitudinal axis z extending in parallel with the light path of the laser beam (1), and having a sensor device (220) which has at least one sensor element (221) and which is arranged to detect the safety light field (3) and to generate a sensor signal (4) that can be varied by means of at least partial covering of the safety light field (3) by the object (2); and an interruption device (300) which is coupled to the at least one light barrier device (200) and which is arranged to interrupt the laser beam (1) according to a change in the sensor signal (4) of the at least one light barrier device (200). The invention also relates to a laser apparatus which is equipped with the safety apparatus (100), to applications of the safety apparatus (100), and to a method for monitoring a light path of a laser beam (1).

IPC Classes  ?

• G02B 26/04 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light by periodically varying the intensity of light, e.g. using choppers
• F16P 3/14 - Safety devices acting in conjunction with the control or operation of a machineControl arrangements requiring the simultaneous use of two or more parts of the body with means, e.g. feelers, which in case of the presence of a body part of a person in or near the danger zone influence the control or operation of the machine the means being photocells or other devices sensitive without mechanical contact
• G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors

Abstract

The present invention relates to a computer-implemented method of calculating the ranges of concentrations, of fluxes, or of reaction rate constants in a network of chemical reactions.

IPC Classes  ?

• G16B 5/00 - ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• G06F 17/16 - Matrix or vector computation

Abstract

The present invention relates to nanocontainers for the synergistic transport of lipophilic and hydrophilic active ingredients or detection reagents. In particular, the nanocontainers according to the invention offer a possibility for diagnosing and/or treating diseases with combinations of active ingredients (therapy) and detection reagents (diagnostics), which have different solubility properties. The present invention further relates to a method for producing the nanocontainers according to the invention.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61K 31/4164 - 1,3-Diazoles
• A61K 31/438 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/5383 - 1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/65 - Tetracyclines
• A61K 31/7052 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
• A61K 49/00 - Preparations for testing in vivo
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

A method of operating a magnetic memory device includes: (i) applying a first current to a free layer of a magnetic tunnel junction structure, which includes a magnetic translation unit (MTU) extending between a first magnetic pad and a second magnetic pad, and a tunnel barrier layer and a pinned layer stacked on the MTU, so that a multi-domain is established within the MTU, (ii) applying a magnetic field to the free layer so that the magnetization direction of the MTU switches to become anti-parallel to the magnetization directions of the first magnetic pad and the second magnetic pad, (iii) applying a second current to the free layer so that a portion of the multi-domain penetrates into the first magnetic pad, and (iv) applying another magnetic field to the free layer so that the magnetization direction of the first magnetic pad switches.

IPC Classes  ?

• G11C 19/08 - Digital stores in which the information is moved stepwise, e.g. shift registers using magnetic elements using thin films in plane structure
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices
• H10N 50/80 - Constructional details

Abstract

The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 and that have been selected for potent cross-reaction and cross-neutralization between the original Wuhan strain and the Alpha, Beta, Gamma, Delta, and Mu variants of concern.

IPC Classes  ?

• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61P 31/14 - Antivirals for RNA viruses

Abstract

A three-dimensional arrangement of nanoscopic devices, the arrangement comprises a scaffold structure; and a plurality of nanoscopic devices, the nanoscopic devices being configured to exhibit a nonreciprocal transmission probability of electron quantum wave packets, wherein the nanoscopic devices are attached to the scaffold structure, wherein a majority of the nanoscopic devices are oriented with one and the same transmission direction of higher transmission probability of the electron quantum wave packets.

IPC Classes  ?

• H10N 19/00 - Integrated devices, or assemblies of multiple devices, comprising at least one thermoelectric or thermomagnetic element covered by groups
• H10N 10/01 - Manufacture or treatment
• H10N 10/82 - Interconnections

Abstract

The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid-modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.

IPC Classes  ?

• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit

Abstract

A method of determining nanoparticle properties of nanoparticles (2) included in a sample (1), comprising the steps of collecting sequential frames of images by employing an interferometric microscope device (110), wherein the sample (1) is illuminated with illumination light (3) from a coherent light source device (111) and the images are created by scattering light (4) from the nanoparticles (2) superimposed with non-scattered reference light, said scattering light and reference light having a wavelength larger than a cross-sectional dimension of the nanoparticles (2), tracking the nanoparticles (2) in the sequential frames of images, wherein at least one interferometric point spread function (iPSF) feature of each of the nanoparticles (2) is established and nanoparticle trajectory motion data are determined for each nanoparticle (2), comprising the nanoparticle positions in each frame, for each nanoparticle (2), calculating a nanoparticle size d from the trajectory motion data of the nanoparticle and calculating an interferometric nanoparticle contrast from the at least one iPSF feature of the nanoparticle.

IPC Classes  ?

• G01N 15/1433 - Signal processing using image recognition
• G01N 15/00 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 15/1434 - Optical arrangements

Abstract

The present invention concerns a lithium metal electrode, in particular for a lithium ion battery, comprising a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm, and wherein metallic lithium is provided on the surface of the metal fibers of the tree-dimensional network of metal fibers. Further, the present invention concerns a Method of manufacturing a lithium metal electrode, wherein the method comprises the steps of a) providing a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, wherein the metal fibers have a thickness and/or width in the range of 0.25 to 200 μm; and b) providing a layer of metallic lithium on the fibers of the three-dimensional network of metal fibers.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/04 - Processes of manufacture in general
• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/70 - Carriers or collectors characterised by shape or form
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

A method for fabricating a magnetic device comprises providing a layer stack, the layer stack comprising a substrate, a first ferromagnetic layer disposed above the substrate, the first ferromagnetic layer comprising a uniaxial magnetic anisotropy including an easy axis, a non-magnetic layer disposed on the first ferromagnetic layer, a second ferromagnetic layer disposed on the non-magnetic layer, the second ferromagnetic layer comprising a unidirectional anisotropy, and an antiferromagnetic layer disposed on the second ferromagnetic layer, the antiferromagnetic layer comprising a Néel temperature TN; heating the layer stack above the Néel temperature TN of the antiferromagnetic layer; applying a magnetic field HCL to the layer stack, the magnetic field HCL comprising a magnetic field direction having an arbitrary angle with respect to the easy axis; cooling the layer stack below the Néel temperature TN of the antiferromagnetic layer with the magnetic field HCL applied; and removing the magnetic field HCL.

IPC Classes  ?

• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region
• H10N 60/01 - Manufacture or treatment
• H10N 60/85 - Superconducting active materials

Abstract

The present invention relates to racetrack memory array devices, and more specifically, to a manufacturing method of racetrack memory arrays with integrated magnetic tunnel junction for read/write.

IPC Classes  ?

• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• H10N 50/01 - Manufacture or treatment
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region

Abstract

The present invention relates to a method for non-invasive production of defined structures inside compartments, wherein the method comprises the steps of: providing a compartment having an inside filled with a liquid, comprising a photoresist, and applying light to the inside of the compartment including the photoresist, wherein the light has a focal point inside the compartment and initiates a chemical reaction of the photoresist at the focal point, creating a defined structure. Further, the present invention relates to a compartment, having an inside, surrounded by a compartment wall, wherein the compartment comprises a defined structure obtainable by a method according to any one of the preceding claims.

IPC Classes  ?

• G03F 7/20 - ExposureApparatus therefor
• B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
• B29K 71/00 - Use of polyethers as moulding material
• B33Y 10/00 - Processes of additive manufacturing
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G03F 7/029 - Inorganic compoundsOnium compoundsOrganic compounds having hetero atoms other than oxygen, nitrogen or sulfur

Abstract

In a first aspect the present invention relates to a system for continuous measurement of osmolarity in situ. Said system comprises phase-separated membrane enclosed compartment as the sensor in osmolarity; detection means: a processing unit, and, optionally, an output unit of absolute or relative osmolarity and/or osmolarity changes. Further, the use of the phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance for non-invasive osmolarity measurement in a liquid system is described. In addition, a method for determining osmolarity and/or osmolarity change in a system is provided including the phase-separated membrane enclosed compartment, whereby the membrane is a permeable to a solvent and non-permeable to the osmotically active substance. Finally, a set of phase-separated membrane enclosed compartment, whereby the membrane is permeable to a solvent and non-permeable to the osmotically active substance, having predetermined different inner osmolarities useful for calibrations of osmolarity of an osmolarity measuring system is disclosed.

IPC Classes  ?

• G01N 13/04 - Investigating osmotic effects

Abstract

The present disclosure relates to an electronic tag for behavioural monitoring of animals, the electronic tag comprising a microprocessor and at least one sensor. The electronic tag is configured to obtain, via the at least one sensor, movement data of an animal to which the electronic tag is attached and to determine, based on the obtained movement data, a behaviour of the animal. The disclosure further encompasses a corresponding method as well as an ear tag.

IPC Classes  ?

• A01K 29/00 - Other apparatus for animal husbandry
• A01K 11/00 - Marking of animals
• A01K 27/00 - Leads or collars, e.g. for dogs

Abstract

A method sequentially transmits signals of polarization states of light through an optical fiber. The optical fiber being a polarization preserving optical fiber. For each signal, a signal state is prepared as one out of a set of at least two non-orthogonal polarization states of light and sent through the optical fiber from a sender site to a receiver site. A method for quantum key distribution using polarization states of light is performed, wherein an alphabet of elementary information values is encoded in a set of non-orthogonal polarization states of light such that each elementary information value is represented by at least one of the polarization states. A classical message of elementary information values out of the alphabet is prepared, wherein the respective polarization states corresponding to the elementary information values of the classical message are prepared at a sender site as signal states.

IPC Classes  ?

• H04B 10/532 - Polarisation modulation
• H04B 10/25 - Arrangements specific to fibre transmission
• H04B 10/70 - Photonic quantum communication

Abstract

The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions: b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.

IPC Classes  ?

• G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
• G16B 5/20 - Probabilistic models
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 30/10 - Sequence alignmentHomology search
• G16B 40/20 - Supervised data analysis

Abstract

The invention relates to an optical component comprising a metasurface, wherein the metasurface comprises a repeating pattern of unit cells, wherein each unit cell comprises at least two different scattering structures, wherein first scattering structures are at least partially contacting a first substance having a first refractive index and second scattering structures are at least partially contacting a second substance, which differs from the first substance, wherein the second substance provides a refractive index which is variable depending on an electrical control signal, wherein a plurality of pairs of first scattering structures contacting the first substance and second scattering structures contacting the second substance are arranged row-wise on electrodes, wherein electrodes supporting neighboring rows of pairs of first and second scattering structures are electrically separated from each other, and a LIDAR system comprising such an optical component. Furthermore, the invention relates to a method for amending a deflection angle of such an optical component.

IPC Classes  ?

• G02F 1/29 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the position or the direction of light beams, i.e. deflection

Abstract

A confocal microscopy apparatus 100 for imaging a sample 2 under investigation by chromatic confocal microscopy comprises an illumination source device 10 being arranged for creating illumination light 1 having an illumination spectrum covering a plurality of illumination wavelengths, a focusing device 40 including at least one focusing lens 41 being configured for focusing the illumination light 1 along an imaging axis z into a plurality of wavelength-dependent focal planes in an axial imaging range of a sample 2 to be investigated, wherein the at least one focusing lens 41 is further arranged for collecting scattering light 3 created in the focal planes of the sample 2, and a detector device 50 being arranged for spectrally resolved detecting of the scattering light 3, wherein the at least one focusing lens 41 is made of a dispersive focusing lens 41 material with an Abbe number equal to or below 8, like e. g. ZnSe. Furthermore, a confocal microscopy method for imaging a sample 2 to be investigated by chromatic confocal microscopy is described.

IPC Classes  ?

• G02B 21/00 - Microscopes

Abstract

The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry. The invention relates to novel caging-group-free photactivatable fluorescent dyes having the structural formula (I) as well as to the corresponding photoactivated fluorescent dyes having the structural formula (II). The invention further relates to the use of the photoactivatable compounds as such or after photoactivation, in particular as fluorescent tags, analytical reagents and labels in optical microscopy, imaging techniques, protein tracking, nucleic acid labeling, glycan analysis, capillary electrophoresis, flow cytometry or as a component of biosensors, or as analytical tools or reporters in microfluidic devices or nanofluidic circuitry.

IPC Classes  ?

• A61K 49/00 - Preparations for testing in vivo
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances

Abstract

The present invention relates to improved methods for obtaining purified contrast agents that are suitable for magnetic resonance imaging. The contrast agents are prepared by a method such dynamic nuclear polarization (DNP), hydrogenative parahydrogen induced polarization (PHIP), or Signal Amplification By Reversible Exchange (SABRE). High degrees of purity are achieved by performing an evaporation step to separate a signal enhanced precursor or the contrast agent from a metal catalyst or a source of radicals.

IPC Classes  ?

• A61K 49/06 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations

Abstract

A method for switching magnetic moments in a magnetic material by: a) heating a system formed from a layer of magnetic material and a layer of a metal contacting and forming an interface with one surface of the magnetic material layer, the heating step increasing the temperature to at least 1 to 100 K above the blocking temperature of the magnetic material, b) applying current pulses having a fall time to the system at least at a point in time when the system is heated to at least 1 to 100 K above the blocking temperature of the magnetic material, thereby generating a spin texture in the magnetic material layer and c) then cooling the system to a temperature of below the blocking temperature at a cooling rate which is greater than the current pulses fall time, thereby setting the spin texture in the magnetic layer.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 11/18 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using Hall-effect devices
• H01F 10/32 - Spin-exchange-coupled multilayers, e.g. nanostructured superlattices
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices
• H10N 50/85 - Materials of the active region
• H10N 52/80 - Constructional details

Abstract

The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps: The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps: providing a loose network out of the plurality of metal fibers at an assembling site; fixing the plurality of metal fibers to one another by forming contact points between the single metal fibers by heating the plurality of fibers at a heating rate higher than 50 K/min, in particular higher than 100 K/min, especially higher than 200 K/min, preferably higher than 1000 K/min, to a fixation temperature selected in the range of 50 to 98% of their melting point temperature; and cooling the plurality of fibers at a cooling rate higher than 50 K/min, preferably higher than 100 K/min. The invention further relates to a network of metal fibers comprising a plurality of metal fibers fixed one to another at contact points, wherein the metal fibers non-round cross section, in particular a rectangular, quadratic, partial circular or an elliptical cross section with a large axis and a small axis, or wherein the metal fibers comprise a round cross section, and wherein the fibers comprise a width which is generally constant along a length of the fiber such that a variation of the width of the fiber along its length is less than 40%, preferably less than 30%, in particular less than 20%.

IPC Classes  ?

• B22F 3/00 - Manufacture of workpieces or articles from metallic powder characterised by the manner of compacting or sinteringApparatus specially adapted therefor
• B01D 39/10 - Filter screens essentially made of metal
• B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
• B22F 1/05 - Metallic powder characterised by the size or surface area of the particles
• B22F 1/062 - Fibrous particles
• B22F 1/08 - Metallic powder characterised by particles having an amorphous microstructure
• B22F 3/10 - Sintering only
• B22F 3/11 - Making porous workpieces or articles
• D04H 1/4234 - Metal fibres
• D04H 1/54 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
• D04H 1/556 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving by infrared heating
• H01M 4/66 - Selection of materials
• H01M 4/80 - Porous plates, e.g. sintered carriers

Abstract

The present invention relates to a method for producing cytidine 5′-monophospho-N-acetyl-neuraminic acid (CMP-Neu5Ac, 1) from low-cost substrates N-acetyl-D-glucosamine (GlcNAc), pyruvate, cytidine and polyphosphate in a single reaction mixture with a set of optionally immobilized or optionally co-immobilized enzymes comprising N-acylglucosamine 2-epimerase (AGE), an N-acetylneuraminate lyase (NAL), an N-acylneuraminate cytidylyltransferase (CSS), a uridine kinase (UDK), a uridine monophosphate kinase and a polyphosphate kinase 3 (PPK3). Further, said process may be adapted to produce Neu5Acylated i.e. sialylated biomolecules and biomolecules including a saccharide, a peptide, a protein, a glycopeptide, a glycoprotein, a glycolipid, a glycan, an antibody, and a glycoconjugate, in particular, an antibody drug conjugate, and a carbohydrate conjugate vaccine, or a flavonoid.

IPC Classes  ?

• C12P 19/46 - Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
• C12N 9/12 - Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
• C12N 9/14 - Hydrolases (3.)
• C12N 9/88 - Lyases (4.)
• C12N 9/90 - Isomerases (5.)

Abstract

The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH2) comprising two protons and at least one heteronucleus (S3, S4), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field (B0) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group (NA, NB, NC) of 180° radio frequency pulses, wherein the first group (NA) of 180° radio frequency pulses is consecutively applied nA times during a first time interval (τA) and wherein the second group (NB) of 180° radio frequency pulses is consecutively applied nB times during a second time interval (τB) after the last first group, and wherein the third group (NC) of 180° radio frequency pulses is consecutively applied nC times during a third time interval (τC) after the last second group, wherein nA, nB, nC are integer numbers, respectively.

IPC Classes  ?

• G01R 33/46 - NMR spectroscopy
• G01R 33/28 - Details of apparatus provided for in groups
• G01R 33/54 - Signal processing systems, e.g. using pulse sequences
• G01R 33/56 - Image enhancement or correction, e.g. subtraction or averaging techniques

Abstract

The present invention relates to an optical element (10) for use with a reaction chamber (70), in particular a reaction chamber (70) of a thermal laser evaporation system, the reaction chamber (70) having a chamber wall (72), with a flange (80) of the reaction chamber (70) being arranged at an opening (74) in the chamber wall (72). Further, the present invention relates to a reaction chamber (70), in particular reaction chamber (70) of a thermal laser evaporation system, comprising a chamber wall (72) enclosing a sealable reaction volume, in particular sealable with respect to the ambient atmosphere, the reaction volume fillable with a reaction atmosphere (90), the reaction chamber (70) further comprising a flange (80) arranged at an opening (74) in the chamber wall (72).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The present invention is directed towards a process for the preparation of free isocyanates, which improves upon the disadvantages associated with heterogeneous catalysis. The process comprises converting formamides into the corresponding isocyanates via a catalytic dehydrogenation, which involves bringing the formamide into contact with a Group VII, VIII or IX transition metal complex and heating.

IPC Classes  ?

• C07C 263/12 - Preparation of derivatives of isocyanic acid from or via nitrogen analogues of carboxylic acids, e.g. from hydroxamic acids, involving a Hofmann, Curtius or Lossen-type rearrangement
• B01J 31/18 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes containing nitrogen, phosphorus, arsenic or antimony
• B01J 31/20 - Carbonyls
• B01J 31/24 - Phosphines

Abstract

The present invention relates to a device for dispensing a measured amount of a particulate material and a method.

IPC Classes  ?

• G01F 19/00 - Calibrated capacity measures for fluids or fluent solid material, e.g. measuring cups

Abstract

The present invention is related to a method of coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention is related to an apparatus (100) for a thermal evaporation system (200) for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated by electromagnetic radiation (80) from a source (30).

IPC Classes  ?

• C23C 16/448 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for generating reactive gas streams, e.g. by evaporation or sublimation of precursor materials
• C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
• C23C 16/48 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating by irradiation, e.g. photolysis, radiolysis, particle radiation

Abstract

The present invention relates to an apparatus (100) for a thermal evaporation system (200) and to a thermal evaporation system (200), respectively, for coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) thermally evaporated and/or sublimated from a source (30) by electromagnetic radiation (80). Further, the present invention relates to a method coating a coating region (58) on a front surface (56) of a substrate (50) with a source material (40) from a source (30) thermally evaporated and/or sublimated by electromagnetic radiation (80).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• C23C 14/50 - Substrate holders

Abstract

A system for performing quantum operations comprising an optical superlattice and a plurality of optical tweezers, wherein the optical superlattice comprises a plurality of main sites; each main site comprises a storage site and an auxiliary site, each configured to hold an atom; the optical superlattice is configured to merge the storage site and the auxiliary site of each main site; and the plurality of optical tweezers is configured to move atoms provided in the plurality of main site from one main site to another main site.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The invention relates to a DEPFET comprising: a semiconductor substrate (100) of a first conduction type, which has a first main surface (101) and a second main surface (102), which are opposite one another; a source terminal region (1s) of a second conduction type on the first main surface (101); a drain terminal region (1d) of a second conduction type; a channel region (10), which is arranged between the source terminal region (1s) and the drain terminal region (1d); a gate electrode (11), which is separated from the channel region (10) by a gate insulator (6); a rear activation region (104) of a second conduction type, which is formed on the second main surface (102); and a substrate doping increase region (2) of a first conduction type, which is formed at least under the source terminal region (1s) and under the channel region (10), the substrate doping increase region (2) having a signal charge control region (20) of the first conduction type below the gate electrode (11), in which signal charge control region the effective doping dose has a higher value than at other points of the substrate doping increase region (2) below the gate electrode.

IPC Classes  ?

• H01L 29/78 - Field-effect transistors with field effect produced by an insulated gate
• H01L 21/265 - Bombardment with wave or particle radiation with high-energy radiation producing ion implantation
• H01L 29/10 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions with semiconductor regions connected to an electrode not carrying current to be rectified, amplified, or switched and such electrode being part of a semiconductor device which comprises three or more electrodes
• H01L 29/423 - Electrodes characterised by their shape, relative sizes or dispositions not carrying the current to be rectified, amplified or switched
• H01L 29/66 - Types of semiconductor device
• H01L 31/113 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by field-effect operation, e.g. junction field-effect photo- transistor being of the conductor-insulator- semiconductor type, e.g. metal- insulator-semiconductor field-effect transistor

Abstract

The present invention relates to antisense-oligonucleotides capable of hybridizing with a region of the gene encoding Efnb2, or with a region of the mRNA encoding Efnb2, and salts and optical isomers of said antisense-oligonucleotides for use in prevention of kidney dysfunction promoted by endothelial dysfunction.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

The present invention relates to a method for preparing a compound suitable for signal enhanced magnetic resonance imaging comprising the steps of vinylating a mono-, di- or tricarboxylic acid comprising a moiety -Q-Z with Q being O or N and Z being a protecting group by using vinyl acetate, cleaving Z, and if Z has not already been converted into an alcohol upon cleavage, converting Q into an alcohol either by using nitrite or by converting Q into bromine followed by hydrolysis yielding a vinyl hydroxy ester. The compounds used may be partly or fully deuterated. Furthermore, the present invention relates to a vinyl hydroxy ester as well as an intermediate of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediate is partly or fully deuterated.

IPC Classes  ?

• C07C 67/31 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• C07C 67/307 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogenPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by substitution of halogen atoms by other halogen atoms
• C07C 67/317 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groupsPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenolysis of functional groups
• C07C 69/63 - Halogen-containing esters of saturated acids
• C07C 69/732 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
• C07C 201/12 - Preparation of nitro compounds by reactions not involving the formation of nitro groups
• C07C 205/34 - Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
• C07C 227/18 - Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
• C07C 229/08 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms

Abstract

The invention relates to a method of preparing a surface of a bulk substrate as an epitaxial template, to an epitaxial template and to a device comprising such an epitaxial template.

IPC Classes  ?

• C30B 35/00 - Apparatus not otherwise provided for, specially adapted for the growth, production or after-treatment of single crystals or of a homogeneous polycrystalline material with defined structure
• C30B 33/02 - Heat treatment

Abstract

The present invention relates to a vinyl keto ester and intermediates of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediates is partly or fully deuterated. Furthermore, the present invention relates to two alternative methods of preparing said vinyl keto ester. The first method is a multi-step approach comprising the steps of providing a carboxylic acid that comprises a geminal diol moiety protected by a photolabile protecting group, vinylating said carboxylic acid using vinyl acetate, and cleaving the protecting group by applying UV light. The second method is a one-step approach of reacting a carboxylic acid that comprises an additional carbonyl moiety with acetylene in the presence of a metal catalyst. In both methods, the compounds used may be fully or partly deuterated.

IPC Classes  ?

• C07C 69/716 - Esters of keto-carboxylic acids
• C07B 59/00 - Introduction of isotopes of elements into organic compounds

Abstract

The present invention is directed to a method for continuous production of cationic lipids. Said cationic lipids are particularly useful in combination with other lipid components for forming lipid nanoparticles with oligonucleotides (e.g. mRNA) to facilitate delivery of therapeutically active nucleic acids.

IPC Classes  ?

• C07C 219/06 - Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton

Abstract

The invention relates to a method of producing a solid-state component, in particular for a quantum component, preferably for a qubit, comprising one or more thin films, the one or more thin films comprising a first material and each said film having a thickness selected between a monolayer and 100 nm and is deposited onto a substrate surface of a substrate, wherein the production process is carried out in a reaction chamber sealed with respect to the ambient atmosphere. Further, the invention relates to a solid-state component, in particular for a quantum component, preferably for a qubit, comprising one or more thin films, one of the one or more thin films comprises a first material with a thickness between a monolayer and 100 nm and is deposited onto a substrate surface of a substrate. In addition, the invention relates to a quantum component comprising such a solid-state component according to the present invention and to an apparatus for producing such a solid-state component according to the present invention.

IPC Classes  ?

• H10N 60/01 - Manufacture or treatment

Abstract

The present invention relates to a method of producing an electrode, comprising the following steps: Step (A) of providing a conductive base material, Step (B) of providing a coating composition comprising an electrode active material and optionally a binder, wherein the coating composition is a free-flowing powder, Step (C) of coating the conductive base material provided in step (A) with the coating composition provided in Step (B), and Step (D) of heating the coated conductive base material obtained in step (C) and optionally compressing the coated conductive base material (14), e.g. by calendering. Further, the present invention relates to an electrode, a dry coating composition, a battery and an electric circuit.

IPC Classes  ?

• H01M 4/139 - Processes of manufacture
• H01M 4/04 - Processes of manufacture in general
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers

Abstract

The present invention relates to an electrode for a mono- or multivalent ion battery, comprising a three-dimensional network of metal fibers, wherein the metal fibers are directly in contact to one another, and an active material, wherein the network of metal fibers has a thickness in the range of 200 μm to 5 mm. Further, the present invention relates to a battery comprising the electrode of the present invention and to an electric vehicle, comprising the battery of the present invention.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/80 - Porous plates, e.g. sintered carriers

Abstract

A modified nanoparticle for use in a therapeutic method, wherein the therapeutic method comprises the administration of the modified nanoparticle to an organism, the targeting of the modified nanoparticles to a specific site in the organism followed by an uptake of the modified nanoparticle into a cell, and wherein the modified nanoparticle is obtainable by a process comprising the steps of i) providing a nanoparticle and ii) contacting the nanoparticle with one or more antibodies as at a pH value of less than 7.0 so as to non-covalently bind the one or more antibodies via its/their Fc region onto the surface of the nanoparticle, wherein the nanoparticle provided in step i) is made of a material having at least one protonable or deprotonable group on the surface thereof and/or the one or more targeting moieties contacted with the nanoparticle in step ii) has at least one protonable or deprotonable group.

IPC Classes  ?

• A61K 9/51 - Nanocapsules
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present disclosure relates to a method for the incorporation of formaldehyde into biomass comprising the following enzymatically catalyzed steps: (1) condensation of pyruvate with formaldehyde into 4-hydroxy-2-oxobutanoic acid (HOB); (2) amination of the thus produced 4-hydroxy-2-oxobutanoic acid (HOB) to produce homoserine; (3) conversion of thus produced homoserine to threonine; (4) conversion of the thus produced threonine into glycine and acetaldehyde or acetyl-CoA; (5) condensation of the thus produced glycine with formaldehyde to produce serine; and (6) conversion of the thus produced serine to produce pyruvate, wherein said pyruvate can then be used as a substrate in step (1). The disclosure also relates to enzymes for catalyzing the corresponding enzymatic reactions and recombinant microorganisms which express the enzymes for catalyzing the corresponding enzymatic reactions.

IPC Classes  ?

• C12P 13/04 - Alpha- or beta-amino acids
• C12N 15/52 - Genes encoding for enzymes or proenzymes
• C12N 15/70 - Vectors or expression systems specially adapted for E. coli

Abstract

A spectroscopic measuring apparatus (100) being configured for measuring a spectral response of a sample (1), in particular a biological sample, comprises a fs laser source device (10) being arranged for an irradiation of the sample (1) with a sequence of probe light pulses (2) having a primary spectrum, a detector device (20) being arranged for a temporally and/or spectrally resolved detection of response light pulses (2′) having an altered spectrum and/or temporal structure and resulting from an interaction of the probe light pulses (2) with the sample (1), and a pulse modification device (30) comprising at least one quantum cascade laser (31 . . . 3N), wherein the pulse modification device (30) is configured to modify at least one of the probe light pulses (2) and the response light pulses (2′) by amplifying one or more spectral components of the at least one of the probe light pulses (2) and the response light pulses (2′) with the at least one quantum cascade laser (31 . . . 3N). Furthermore, a method of measuring a spectral and/or temporal response of a sample (1), preferably a biological sample, is described.

IPC Classes  ?

• G01N 21/3563 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solidsPreparation of samples therefor
• G01N 33/483 - Physical analysis of biological material

Abstract

The present invention relates to a composition comprising at least one inhibitor of mitochondrial transcription (IMT) and at least one anti-cancer drug. Furthermore, the present invention is directed to compositions for use as a medicament and to compositions for use in the treatment and/or prevention of cancer.

IPC Classes  ?

• A61K 31/166 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
• A61K 31/4184 - 1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
• A61K 31/453 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
• A61K 31/47 - QuinolinesIsoquinolines
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61P 35/00 - Antineoplastic agents

Abstract

The invention concerns a method for measuring a force on at least one particle in a fluid wherein an inhomogeneous field of hydrodynamic flows is generated in a fluid by specific dynamic localized heating events, the particle is spatially manipulated by the hydrodynamic flows, a spatial configuration of the particle(s) within the fluid is captured and at least one force acting on the particle(s) is determined by evaluating the captured spatial configuration of the particle(s). The invention concerns furthermore an apparatus for measuring a force on at least one particle in a fluid, a computer program product, and a computer-readable storage medium.

IPC Classes  ?

• G01N 15/1434 - Optical arrangements
• G01N 15/1404 - Handling flow, e.g. hydrodynamic focusing
• G01N 15/1429 - Signal processing

Abstract

The invention relates to a method for processing a measuring probe which is intended for detecting surface properties or for modifying surface structures in the sub-micrometer range. The method comprises at least the following steps. First, providing a precursor containing molecules polymerizable by light or electron beams and a measuring probe comprising at least one carrier with a tip having an upper end opposite the carrier and a light or electron source for emitting light or electron beams with a wavelength and intensity, which fulfil an energy input at least required for polymerization of the precursor and means for variable positioning of the light or electron source and a control file and an electronic data processing system, wherein the control file describes at least a part of the surface of the measuring probe and serves to control a change in position of the light or electron source. In the following step, the measuring probe is covered with the precursor and the measuring probe is arranged in the beam path of the light or electron beams, whereupon the precursor is exposed to the light or electron beam at several positions that touch each other and are specified in the control file, leaving out the tip of the measuring probe. The unexposed areas of the precursor are then removed by means of a water or solvent bath or controlled air or gas flow and, if necessary, the areas polymerized by exposure are finally developed. The invention also includes measuring probes which are manufactured using the inventive method.

IPC Classes  ?

• G01Q 70/14 - Particular materials
• G01Q 70/16 - Probe manufacture

Abstract

The present invention relates to a drive arrangement (1), preferably a worm gear drive arrangement (1), with an output element (3) for performing an output movement and a driving element (2) for driving the output element (3), wherein the driving element (2) and the output element (3) are arranged spaced apart (7) from each other in a contactless manner, wherein at least one magnetic unit (4) for generating a magnetic field (MF) is coupled to the driving element (2) for magnetization at least one driving portion (2P1, 2P2) of the driving element (2), wherein the least one driving portion (2P1, 2P2) is configured to transmit the magnetic field (MF, tMF) at least partially to the output element (3) to drive the output element (3) upon a rotational movement of the driving element (2).

IPC Classes  ?

• H02K 49/10 - Dynamo-electric clutchesDynamo-electric brakes of the permanent-magnet type
• F16H 1/16 - Toothed gearings for conveying rotary motion without gears having orbital motion involving only two intermeshing members with non-parallel axes comprising worm and worm-wheel

Abstract

An electric machine, in particular a motor or a generator, comprising a rotor and a stator, wherein the rotor comprises a planar, ring-shaped rotor base element and the stator comprises a planar ring-shaped stator base element, wherein the rotor base element and the stator base element are aligned along an axial axis (Z) of the electric machine, wherein a plurality of magnet elements are arranged around the circumference of the ring-shaped rotor base element forming a Halbach magnet-ring assembly, wherein the Halbach magnet-ring assembly generates a magnetic field (BR) with axial and azimuthal components, wherein a plurality of coils are arranged around the circumference (C) of the ring-shaped stator base element.

IPC Classes  ?

• H02K 21/24 - Synchronous motors having permanent magnetsSynchronous generators having permanent magnets with stationary armatures and rotating magnets with magnets axially facing the armatures, e.g. hub-type cycle dynamos
• H02K 1/14 - Stator cores with salient poles
• H02K 1/2795 - Rotors axially facing stators the rotor consisting of two or more circumferentially positioned magnets

Abstract

The present invention relates to a method for optimizing material properties of components of a battery comprising the following steps: Inputting material parameter data, with said material parameter data relating to properties of constituents of the components of the battery; simulating one or more components and/or constituents of components of the battery using a simulation model which takes the material parameter data as input to generate simulation result data as output, with the simulation result data comprising at least one of the following data: data on microscopic geometric features of the component, data on a conductivity of the component, data on a current collector, data on a binder phase, data on a diffusivity of the electrolyte and data on a charging and discharging potential of the component; training an AI model with the material parameter data as input and the simulation result data as output; evaluating a final accuracy of the AI model with respect to the simulation model using extended material parameter data; using the AI model to output material properties of the constituents of the components of the battery. The invention further relates to a method for manufacturing a fiber network, to an electrode and to a battery.

IPC Classes  ?

• H01M 4/66 - Selection of materials
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• H01M 4/02 - Electrodes composed of, or comprising, active material
• H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
• H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries

Abstract

A first aspect of the invention relates to a non-covalently-HaloTag-binding compound characterized by the general formula D-L-T (I), wherein D is or comprises a functional moiety Z, particularly a fluorescent dye, or D is a linkable moiety (i.e. a moiety that can be coupled to other functional groups), L is a linear linker of 10-15 atoms in length, and T is a moiety selected from the group comprising methylamine, methylsulfonamide, acetamide, or their respective fluorinated analogues, azide, or hydroxyl. Another aspect of the invention relates to a HaloTag variant wherein position D106 of the HaloTag7 sequence is exchanged for a proteinogenic amino acid different from D. The variant has a different binding specificity for HaloTag substrates compared to the non-variant Halotag polypeptide. Yet another aspect of the invention relates to kits comprising polypeptides or nucleic acids and the non-covalently-HaloTag-binding compound according to the invention.

IPC Classes  ?

• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• C07K 14/00 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof

Abstract

The present invention relates to method for decreasing temperature of a sample, in particular a method for ultra-rapid cryofixation of a sample for time and spatially resolved microscopic measurements as well as a device for ultra-rapid cryofixation of a sample at any particular time point of interest on a microscope. Said method and device are particularly useful for studying native molecular organization as well as (bio)chemical reactions within living cells with spatial and spectroscopic resolution beyond the fundamental limits caused by molecular motion at positive Celsius temperatures.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• G01N 1/28 - Preparing specimens for investigation
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A method for photonic sampling of a test-waveform is provided. The method includes providing a sampling light pulse and generating a local oscillator by frequency multiplication of the sampling light pulse. The method further includes generating a signal wave by frequency mixing of the sampling light pulse and the test-waveform in a nonlinear optical element, wherein the frequency multiplication of the sampling light pulse and the frequency mixing of the sampling light pulse and the test-waveform are selected such that the local oscillator and the signal wave are at least partly spectrally overlapping. Moreover, the method includes detecting an interference signal of the local oscillator and the signal wave for various time delays of the sampling light pulse with respect to the test-waveform. A device for sampling a test-waveform is also disclosed.

IPC Classes  ?

• G01J 11/00 - Measuring the characteristics of individual optical pulses or of optical pulse trains
• G01J 9/04 - Measuring optical phase differenceDetermining degree of coherenceMeasuring optical wavelength by beating two waves of the same source but of different frequency and measuring the phase shift of the lower frequency obtained

Abstract

The present invention relates to System for analysing tissue, comprising: a dissociation means for at least partially dissociating a tissue sample so as to obtain individual cells, a microfluidic flow device through which a fluid comprising the dissociated cells can be made to flow, and an evaluation device arranged to evaluate the cells as they are being transported through the microfluidic flow device, the system preferably being arranged for a label free analysis of tissue.

IPC Classes  ?

• G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
• G01N 1/28 - Preparing specimens for investigation
• G01N 1/40 - Concentrating samples
• G01N 15/10 - Investigating individual particles
• G01N 15/1433 - Signal processing using image recognition
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

The invention concerns a method for spatially manipulating at least one particle in a fluid, wherein the particle or the particles is/are spatially manipulated in the fluid by hydrodynamic flows which are generated in the fluid by means of dynamic localized heating of the fluid. The method according to the invention is characterized in that at least one target spatial configuration of the particle(s) in the fluid is defined and that the following further steps are carried out: a) an actual spatial configuration of the particle(s) is captured, b) a specific dynamic localized heating event to be applied to the fluid is determined in dependence of at least one recent actual spatial configuration of the particle(s) and a target configuration of the particle(s), c) the specific dynamic localized heating as determined in step c) is applied at least once to the fluid and d) at least one or all of the steps a) to c) are repeated. The invention concerns furthermore an apparatus for spatially manipulating at least one particle in a fluid by means of hydrodynamic flows a computer program product and a computer-readable storage medium.

IPC Classes  ?

• G01N 15/1409 - Handling samples, e.g. injecting samples
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 15/1434 - Optical arrangements
• G02B 21/32 - Micromanipulators structurally combined with microscopes
• G01N 15/1404 - Handling flow, e.g. hydrodynamic focusing

Abstract

For determining a molecule position of a singularized fluorophore molecule, a light beam including fluorescence excitation light and fluorescence influencing light is shaped and focused such as to form a light intensity distribution having a central intensity minimum of the fluorescence influencing light. The central intensity minimum is continuously moved along a track repeatedly extending around an estimated position. Individual photons of fluorescence light emitted by the fluorophore molecule due to excitation by the fluorescence excitation light are registered; and an intensity minimum position of the intensity minimum is recorded for the excitation of each individual photon registered. In response, the estimated position around which the track extends is updated on basis of the recorded intensity minimum position, and extensions of the track around the estimated position are reduced and an effectiveness of the fluorescence influencing light is increased.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present invention relates to the recombinant production of a protein of interest in a prokaryotic host cell or eukaryotic host cell wherein the protein of interest is obtained in a correctly folded and stable form. The protein of interest may be a difficult-to-make polypeptide for use as a vaccine or a pharmaceutical. The protein of interest is co-expressed with or fused to a ‘fold promoter’, which may be a VHH antibody recognizing the said protein.

IPC Classes  ?

• A61K 39/215 - Coronaviridae, e.g. avian infectious bronchitis virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• C07K 16/10 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

The present invention relates to the provision of new means and methods for enzymatic peptide-peptide ligation. In particular, the present invention provides a novel family of transpeptidase enzymes, herein subsequently also referred to as Adriase (Archaeal Peptide Recombinase), transpeptidase or polypeptide recombinase. The members of the Adriase family, which are characterized by an N-terminal DUF2121 domain with an N-terminal serine or threonine residue were surprisingly found to recombine and ligate substrate peptides in a sequence specific manner via a short DUF2121 recognition motif. This way, compounds like proteins, synthetic compounds and/or whole cells may be linked specifically as long as they contain the motif or the parts thereof recognized by an Adriase enzyme. The ligation reaction described herein can be used to engineer novel molecules in a modular way, with broad applications in both research and pharmacology.

IPC Classes  ?

• C12N 9/48 - Hydrolases (3.) acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
• C07K 17/00 - Carrier-bound or immobilised peptidesPreparation thereof

Abstract

The present invention relates to a microfluidic device for introducing pores into and/or enhancing the diameter of pores in the cell membrane of a cell by cell deformation for delivery of cargo molecules into said cell, the device comprising: an inlet and an outlet; and at least one microfluidic channel positioned between said inlet and said outlet, defining a lumen, adapted to allow a cell and cargo molecules in a suspension solution to pass therethrough; wherein the at least one microfluidic channel comprises at least two constrictions with different cross-sections, wherein one of said constrictions has a cross-section that is larger than the average cross-section of said cell and adapted to apply hydrodynamic forces to said cell and a second of said constrictions has a cross-section that is equal to or smaller than the average cross-section of said cell and adapted to apply contact-based compression forces to said cell, while allowing said cell to pass through said constrictions.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A method of passively enhancing pulsed laser light by coherent addition of laser pulses in an enhancement cavity (20) comprises the steps of generating a sequence of seed laser pulses (1) with a repetition frequency frep and a frequency comb spectrum (3) comprising frequency comb lines (4) with frequency comb line spacings equal to the repetition frequency frep, coupling the seed laser pulses (1) via a first plate-shaped coupling element (25) into an enhancement cavity (20) comprising at least two cavity mirrors (21, 22, 23, 24) having metallic surfaces and spanning a cavity beam path (26) with a resonator length L, wherein the enhancement cavity (20) has a fundamental transverse mode TEM00 and higher-order transverse cavity modes TEMnm, each with a series of cavity resonance frequencies (5), and a cavity offset frequency (6), and coherent superposition of the seed laser pulses (1) in the enhancement cavity (20), so that at least one enhanced circulating cavity pulse (2) per cavity length is generated, wherein the frequency comb spectrum (3) is a harmonic frequency comb spectrum (3) with a vanishing seeding comb offset frequency, the enhancement cavity (20) is adjusted such that a round-trip carrier-envelope phase slippage of the circulating cavity pulses 2 is equal to 360°/N for the fundamental transverse mode TEM00, N being an integer number equal to or above (2), and a frequency overlap is provided for a plurality of the cavity resonance frequencies (5) with a plurality of the frequency comb lines (4) along the frequency comb spectrum (3). Furthermore, a laser pulse enhancement apparatus and applications thereof, e. g. in field-resolved spectroscopy, are described.

IPC Classes  ?

• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating

Abstract

An optofluidic antenna device (100) for shaping a light field of sample light emitted or scattered by a sample (1) comprises a substrate (10) and a liquid layer (20) being supported by the substrate (10) and being arranged for accommodating the sample (1) to be investigated between a first liquid surface (21) facing to the substrate (10) and a second liquid surface (22) opposite to the first liquid surface (21), wherein a thickness of the liquid layer (20) between the first and second liquid surfaces (21, 22) and refractive indices of the substrate (10) and the liquid layer (20) are selected such that an optofluidic antenna is formed, which is capable of directing the sample light mainly towards the substrate (10), and a gas volume (30) is arranged above the liquid layer (20), so that the second liquid surface (22) is formed as a liquid-gas-interface. Furthermore, a measuring apparatus (300), that comprises the optofluidic antenna device (100), and a method of detecting at least one photon emitted or scat-tered from a sample (1), in particular a single analyte in a liquid, are described.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present invention relates to a method of making one or more fibrils, the method comprising the steps of providing a material of manufacture of the one or more fibrils; providing a random initial shape of the one or more fibrils, with each fibril of the one or more fibrils comprising several surfaces; calculating an adhesive force of the one or more fibrils based on the material of manufacture of the one or more fibrils and on the provided random initial shape of the one or more fibrils, i.e. of their several surfaces; adapting, in particular iteratively adapting, the random initial shape of the one or more fibrils to vary the adhesive force of the one or more fibrils to form resultant shapes of the one or more fibrils and determining the corresponding adhesive force of each resultant shape of the one or more fibrils; selecting the resultant shape of the one or more fibrils having the highest adhesive force of the one or more fibrils; and producing one or more fibrils having the selected resultant shape having the highest adhesive force of the one or more fibrils. The invention further relates to a computer implemented method of simulating an adhesive force of one or more fibrils and to a fibril.

IPC Classes  ?

• B29C 39/02 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor for making articles of definite length, i.e. discrete articles
• G06F 30/23 - Design optimisation, verification or simulation using finite element methods [FEM] or finite difference methods [FDM]
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model

Abstract

A photonic element for a quantum information processing device contains a high-purity silicon layer. The high-purity silicon layer contains integrated rare-earth element (REE) dopants at a concentration of 1019 cm−3 or less. An optical transition between the lowest crystal field levels of the REE dopants integrated in the high-purity silicon layer exhibits a homogeneous linewidth of 1 MHz or less at a temperature of 4 K or less. A method for producing such a photonic element is also disclosed.

IPC Classes  ?

• G06N 10/40 - Physical realisations or architectures of quantum processors or components for manipulating qubits, e.g. qubit coupling or qubit control

Abstract

The present invention relates to a storage device (1) for storing cryogenic samples (2), comprising at least one sample holder (3), the sample holder being configured to hold at least one cryogenic sample (2). According to the present invention, the storage device (1) further comprises an elongated sample transport unit (4) configured to releasably hold the at least one sample holder (3) and to be inserted into an internal space (50) of a cryogenic storage dewar (5) through an opening (51) of the cryogenic storage dewar to completely submerge the sample transport unit into a cryogenic liquid (6) residing in the internal space, wherein the sample transport unit is further configured to move said at least one sample holder along a predefined path from a storage position into a removal position, from which the at least one sample holder can be removed from the internal space of the cryogenic storage dewar. The sample transport unit may comprise a chain (40) to be circulated to move the sample holder along said pre-defined path, the chain being looped around a first and a second toothed wheel (41,42).

IPC Classes  ?

• A01N 1/02 - Preservation of living parts
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The present invention relates to an enzyme-catalyzed process for producing GDP-fucose from low-cost substrates guanosine and L-fucose or guanosine and D-Mannose in a single reaction mixture. Said process can be operated (semi)continuously or in batch mode. Further, said process can be adapted to produce fucosylated molecules and biomolecules including glycans, such as human milk oligosaccharides, proteins, peptides, glycoproteins or glycopeptides.

IPC Classes  ?

• C12P 19/44 - Preparation of O-glycosides, e.g. glucosides

Abstract

The invention relates to materials with permanent magnetic properties—also known as hard magnets—having the formula (Fe1-y Coy)2P1-xZx with Z=Si, Ge, B, As; and 0.5≤x≤0.5, and 0.05≤y≤0.3. The invention further relates to the hard magnet itself and a process for making the hard magnets.

IPC Classes  ?

• H01F 1/047 - Alloys characterised by their composition
• B22F 1/10 - Metallic powder containing lubricating or binding agentsMetallic powder containing organic material
• C22C 33/02 - Making ferrous alloys by powder metallurgy
• C22C 38/00 - Ferrous alloys, e.g. steel alloys
• C22C 38/02 - Ferrous alloys, e.g. steel alloys containing silicon
• C22C 38/10 - Ferrous alloys, e.g. steel alloys containing cobalt

Abstract

The present invention relates to a monoclonal antibody 3D9 specifically binding a C-terminal fragment of cleaved histone H3 in NETs that can be used to specifically detect NETs distinguishing them from chromatin of different origin. The invention also provides a method for in vitro detection of neutrophil extracellular traps in isolated biological samples as well as a method for assessing a disease condition associated with NET formation. The present invention also relates to an isolated fragment of human histone H3 cleaved at site L48R49, and to the use of cleavage site L48R49 for specific detection of human neutrophil extracellular traps. The present invention also relates to recombinant nucleic acid sequences encoding said polypeptides, and host cells comprising the same.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The invention relates in a first main aspect to self-supporting mistletoe viscin films comprising a 2-dimensional multi-axial oriented array of viscin cellulose filaments within a humidity-responsive matrix and methods for preparing the same. A further aspect relates to 2D and 3D mistletoe viscin scaffolds and methods for preparing the same. Another main aspect of the invention relates to the use of mechanically isolated mistletoe viscin or of said self-supporting mistletoe viscin films for joining or binding together a plurality of materials with diverse surface characteristics and to an adhesive comprising such viscin films and/or 2D or 3D viscin scaffolds. In more specific embodiments, the invention relates to a wound sealant and coating composition or to a medical kit comprising mechanically isolated mistletoe viscin in the hydrated/wet state and a plant oil, or a dried viscin film for use, after rehydration under humid conditions, as a wound sealant.

IPC Classes  ?

• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices

Abstract

A method of creating a local oscillator light beam LO for a phase-resolved spectroscopy measurement comprises the steps of providing a first measuring light beam (1) and a second measuring light beam (2) being aligned to each other, creating the local oscillator light beam LO by an optical non-linear interaction of a first portion (1A) of the first measuring light beam (1) and a first portion (2A) of the second measuring light beam (2) in an optical nonlinear medium (20), and superimposing the local oscillator light beam LO, a second portion (1B) of the first measuring light beam (1) and a second portion (2B) of the second measuring light beam (2) with a predetermined mutual phase relationship, for providing a sample light beam (3) for the phase-resolved spectroscopy measurement. The local oscillator light beam LO and the second portions (1B, 2B) of the first and second measuring light beams (1, 2) are superimposed with a displaced Sagnac interferometer (10).

IPC Classes  ?

• G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
• G01J 3/453 - Interferometric spectrometry by correlation of the amplitudes

Abstract

The present invention relates to a method of roll-to-roll manufacturing of a 3D-patterned microstructure. Further, the present invention relates to a 3D-patterned microstructure obtained by the method. In addition, the present invention relates to a use of a 3D-patterned microstructure manufactured according to the method. Furthermore, the present invention relates to an apparatus for manufacturing a 3D-patterned microstructure, the apparatus being configured to carry out the method.

IPC Classes  ?

• B29C 43/22 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of indefinite length
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B29C 43/24 - Calendering
• B29C 43/36 - Moulds for making articles of definite length, i.e. discrete articles

Abstract

The present invention relates to a method of providing a reaction chamber (10) for a laser evaporation system (100), the reaction chamber (10) comprising at least one wall section (20) with an inner surface (22) facing a reaction volume (12) of the laser evaporation system (100). In addition, the present invention relates to a reaction chamber (10) for a laser evaporation system (100), the reaction chamber (10) comprising at least one wall section (20) with an inner surface (22) enclosing a reaction volume (12). Further, the present invention relates to a laser evaporation system (100) comprising a reaction chamber (10).

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• C30B 23/06 - Heating of the deposition chamber, the substrate, or the materials to be evaporated

Abstract

A laser system generates laser pulses having a determined carrier-envelope-offset, CEO. The laser system includes a Cr-doped II-VI based laser oscillator system having a resonator cavity, which emits laser pulses having a peak power of at least 0.75 MW. The laser system further includes a nonlinear optical element for spectrally broadening at least a part of the emitted laser pulses irradiated onto the nonlinear optical element to provide the laser pulses with octave-spanning spectral components, and a frequency-doubling element for generating second harmonic spectral components of at least a part of the octave-spanning spectral components. In addition, the laser system includes an f-2f-interferometry device for generating a beating signal of at least a part of the overlapping spectral components exiting the frequency-doubling element and interfering with each other at the f-2f-interferomtry device and for determining and/or controlling the CEO of the emitted laser pulses based on the beating signal.

IPC Classes  ?

• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/102 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation

Abstract

A laser oscillator system includes a resonator cavity for confining an intra-cavity laser beam. The laser oscillator system further includes a Cr-doped II-VI gain medium arranged within the resonator cavity and an imaging unit forming part of the resonator cavity. The imaging unit is configured to decouple a spot size of the intra-cavity laser beam at the gain medium from an intra-cavity length of the resonator cavity. Moreover, the resonator cavity and the imaging unit are configured such that the laser oscillator system emits laser pulses at a repetition rate of 50 MHz or less. Further, a laser system and methods for generating light pulses having spectral components at a wavelength of at least 2 μm are disclosed.

IPC Classes  ?

• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/08 - Construction or shape of optical resonators or components thereof
• H01S 5/14 - External cavity lasers

Abstract

The present invention is related to a thermal laser evaporation system (10), the thermal laser evaporation system (10) comprising: a reaction chamber (20) with a chamber wall (30) for enclosing a reaction volume (22); a target (12) arranged in the reaction volume (22), the target comprising one or more materials (M) to be evaporated; a laser light source (40) for providing a thermal laser beam (42) for evaporating said one or more materials (M) from the target (12), the thermal laser beam having a general propagation direction (46); and a chamber window (38) in the chamber wall (30) for conducting the thermal laser beam (42) into the reaction volume (22);

IPC Classes  ?

• C23C 14/28 - Vacuum evaporation by wave energy or particle radiation
• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/12 - Working by laser beam, e.g. welding, cutting or boring in a special environment or atmosphere, e.g. in an enclosure
• C23C 14/24 - Vacuum evaporation
• C23C 14/56 - Apparatus specially adapted for continuous coatingArrangements for maintaining the vacuum, e.g. vacuum locks

Abstract

The present invention relates to a method of purifying peptides and/or polypeptides, said method comprising or consisting of: (a) loading a sample comprising peptides and/or polypeptides under acidic or neutral aqueous conditions on mixed-phase solid phase extraction (SPE) material, wherein said material consists of or comprises reversed phase/ion exchange material; (b) washing said mixed-phase SPE material with (ba) an acidic or neutral composition comprising at least 50% (v/v) organic solvent; and/or (bb) an acidic or neutral aqueous solution; and (c) eluting said peptides and/or polypeptides from said mixed-phase SPE material with an alkaline composition comprising at least 50% (v/v) organic solvent.

IPC Classes  ?

• C07K 1/16 - ExtractionSeparationPurification by chromatography

Abstract

The present invention relates to a device for recording and storing of measurement data related to an object or living subject. The device comprises at least one sensor configured to measure data related to the object or living subject, a memory, and a controller configured to store the measured data in the memory. At least one photosensitive element is configured to convert electromagnetic radiation into electrical current. A transceiver is configured to transmit the measured and/or stored data and to receive data signals. At least one capacitor is configured to store electrical current from the at least one photosensitive element. The controller is configured to measure the voltage of the at least one capacitor. The controller is further configured to forecast an output voltage of the at least one capacitor based on measured voltages, and the controller is configured to increase or decrease the rate of sampling and storing of the measured data in the memory and/or to increase or decrease the rate of transmitting the measured and/or stored data depending on the measured voltage or the forecasted voltage.

IPC Classes  ?

• G01D 9/00 - Recording measured values

Abstract

The present invention is related to a method for running a laser system (10) for providing a laser beam (22) for heating a surface (68) of a target (66) located in a reaction chamber (62) of an evaporation system (60), the laser system (10) comprising a laser light source (20) for providing an at least essentially parallel laser beam (22) with an at least essentially centrally peaked intensity profile (24). In addition, the present invention is related to a laser system (10) for heating a surface (68) of a target (66) located in a reaction chamber (62) of an evaporation system (60), the reaction chamber (62) comprising a chamber window (64), and the laser system (10) comprising a laser light source (20) for providing an at least essentially parallel laser beam (22) with an at least essentially centrally peaked intensity profile (24). Further, the present invention is related to an evaporation system (60) the evaporation system (60) comprising a target (66) located in a reaction chamber (62) and at least one laser system (10) for heating a surface (68) of the target (66).

IPC Classes  ?

• B23K 26/06 - Shaping the laser beam, e.g. by masks or multi-focusing
• B23K 26/073 - Shaping the laser spot
• B23K 26/36 - Removing material
• B23K 26/70 - Auxiliary operations or equipment

Abstract

A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

IPC Classes  ?

• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
• A61P 25/24 - Antidepressants

Abstract

The disclosure relates to a sensor arrangement for sensing forces, including a measurement surface and optical detection of reflected light. The disclosure relates further to corresponding fabrication methods.

IPC Classes  ?

• G01L 1/24 - Measuring force or stress, in general by measuring variations of optical properties of material when it is stressed, e.g. by photoelastic stress analysis
• G01L 5/00 - Apparatus for, or methods of, measuring force, work, mechanical power, or torque, specially adapted for specific purposes