Abstract

A starch-indole-acid derivative, a preparation method therefor, and a use thereof are provided. The starch-indole-acid derivative refers to esterified starch generated by starch undergoing an esterification reaction together with indole acid under the action of a condensing agent and a base. The derivative has high resistance and can resist degradation in the stomach and small intestine. After reaching the colon, the derivative can be fermented by intestinal flora to release indole acid, which is beneficial to intestinal health. The starch-indole-acid derivative has significant advantages and can significantly increase the content of indole acid in colon and hepatic portal blood. In addition, indole acid can activate aryl hydrocarbon receptors to play an immunomodulatory role, which can be combined with the regulatory effect of starch releasing short-chain fatty acids by undergoing fermentation by intestinal flora, providing a product that synergistically exerts immune regulatory effects by means of multiple immune system signaling pathways.

IPC Classes  ?

• C08B 31/04 - Esters of organic acids
• A61K 31/718 - Starch or degraded starch, e.g. amylose, amylopectin
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

The present application provides a starch-indole acid derivative, a preparation method therefor, and a use thereof and relates to the technical field of modified starch. The starch-indole acid derivative refers to esterified starch generated by starch undergoing an esterification reaction together with indole acid under the action of a condensing agent and a base. The derivative has high resistance and can resist degradation in the stomach and small intestine. After reaching the colon, the derivative can be fermented by intestinal flora to release indole acid, which is beneficial to intestinal health. Compared with traditional administration methods such as gavage and intraperitoneal injection, the described means has significant advantages and can significantly increase the content of indole acid in colon and hepatic portal blood. In addition, indole acid can activate aryl hydrocarbon receptors to play an immunomodulatory role, which can be combined with the regulatory effect of starch releasing short-chain fatty acids by undergoing fermentation by intestinal flora, providing a product that synergistically exerts immune regulatory effects by means of multiple immune system signaling pathways.

IPC Classes  ?

• C08B 31/04 - Esters of organic acids
• C08B 33/02 - Esters
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]