C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical and veterinary preparations, namely, materials, namely, synthetic bone grafts for biomedical applications; Pharmaceutical and veterinary preparations, namely, biomedical materials in the nature of synthetic bone grafts, synthetic bone implants, synthetic bone scaffolds, bone adhesives, artificial bone coatings, bone cement for surgical and orthopaedic purposes; surgical implants comprising living tissue for guided tissue regeneration in bone surgery and grafting; material for use in setting bone fractures, namely, bone fillers consisting of bioceramic material; sanitary preparations for medical use; medical plasters, materials for dressings, namely, bandages and gauze; material for stopping teeth; all purpose disinfectants; preparations for destroying vermin Synthetic materials, namely, synthetic bone substitutes for biomedical applications; biomedical materials, namely, synthetic bone substitutes; artificial bone implants; artificial bone grafts; artificial bone coatings
C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.
A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
University Court of the University of Aberdeen (United Kingdom)
ApaTech Limited (United Kingdom)
Inventor
Gibson, Iain R.
Skakle, Janet M. S.
Hadden, Daniel J.
Buckland, Thomas
Abstract
The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material.
The present invention also provides a synthetic carbonate and silicate co-substituted hydroxyapatite material, as well as a biomedical material.
C09C 1/02 - Compounds of alkaline earth metals or magnesium
A61L 27/12 - Phosphorus-containing materials, e.g. apatite
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
C01B 25/32 - Phosphates of magnesium, calcium, strontium, or barium
A delivery device for semi-solid implantable material such as synthetic bone graft substitutes. The device includes a handle, a cylinder extending from the handle and having an outlet at its distal end. A piston is operated by a trigger and is slidable within the cylinder to displace the material from the cylinder. The cylinder has a substantially constant inner diameter along its entire length such that the outlet has substantially the same inner diameter as the rest of the cylinder. When the trigger is fully depressed, a ratchet mechanism is disengaged allowing the piston to be pulled back to a starting position.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Orthopaedic articles; prostheses; prosthetic devices; dental implants; medical devices. Scientific and industrial research; scientific and industrial research services; scientific research; scientific research services.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Biomedical materials, namely, artificial bone coatings, artificial bone void fillers. Synthetic materials, namely, synthetic bone substitutes for biomedical applications; biomedical materials, namely bone implant material; synthetic bone substitutes; artificial bone implants; artificial bone grafts; artificial bone scaffolds; artificial bone parts to be implanted in natural or artificial bones, namely, bone coating and bone void fillers.
A biocompatible material comprising a resorbable polymer matrix and at least one additive, wherein the resorbable polymer matrix comprises : (i) at least one non-random copolymer of poly (alkylene oxide) s, and(ii) at least one poly (alkylene glycol) polymer and/or at least one methoxypoly (alkylene glycol) polymer, and wherein the at least one additive is selected from solid particles, porous particles, hollow particles, polymers, inert fillers, bioactive compounds, colour pigments and combinations of two or more thereof.
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19 mJ/m.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A bone graft material is provided comprising granules of synthetic bone material, at least some of which have a solid coating comprising a blood-clotting agent. A device for delivering bone-replacement material to a an area to be treated is also provided, the device comprising: a chamber for containing bone-replacement material, wherein the chamber is pre-loaded and/or pre-coated on an interior surface thereof with a blood-clotting agent; means for introducing bone-replacement material into the chamber to contact the blood-clotting agent; and a means for delivering the bone-substitute material from the chamber to the area to be treated.
University Court of the University of Aberdeen (United Kingdom)
Apatech Limited (United Kingdom)
Inventor
Gibson, Iain R.
Skakle, Janet M. S.
Hadden, Daniel J.
Buckland, Thomas
Abstract
The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material. The present invention also provides a synthetic carbonate and silicate co-substituted hydroxyapatite material, as well as a biomedical material.
A delivery device for semi-solid implantable material such as synthetic bone graft substitution. The device comprises a handle (1), a cylinder (2) extending from the handle and having an outlet at its distal end. A piston (23) is operated by a trigger (5) and is slidable within the cylinder to displace the material from the cylinder. The cylinder has a substantially constant inner diameter along its entire length such that the outlet has substantially the same inner diameter as the rest of the cylinder. When the trigger is fully depressed, a ratchet mechanism (14, 32) is disengaged allowing the piston to be pulled back to a starting position.
A delivery device for semi-solid implantable material such as synthetic bone graft substitutes. The device comprises a handle (1), a cylinder (2) extending from the handle and having an outlet at its distal end. A piston (23) is operated by a trigger (5) and is slidable within the cylinder to displace the material from the cylinder. The cylinder has a substantially constant inner diameter along its entire length such that the outlet has substantially the same inner diameter as the rest of the cylinder. When the trigger is fully depressed, a ratchet mechanism (14, 32) is disengaged allowing the piston to be pulled back to a starting position.
A61B 17/58 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
A61B 17/60 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements for external osteosynthesis, e.g. distractors or contractors
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A bone replacement filler comprising a biomedical ceramic particulate, wherein the filler is able to flow without the application of an external shear stress or compressive force or under a relatively low shear stress or compressive force, but resists flow or does not flow when subjected to a higher shear stress or compressive force, and wherein at least some of the particles in the ceramic particulate have a micro-porous surface structure and/or a micro-porous sub-surface structure.
The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19mJ/m
A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.
A bone graft material is provided comprising granules of synthetic bone material, at least some of which have a solid coating comprising a blood-clotting agent. A device for delivering bone-replacement material to a an area to be treated is also provided, the device comprising: a chamber for containing bone-replacement material, wherein the chamber is pre-loaded and/or pre-coated on an interior surface thereof with a blood-clotting agent; means for introducing bone-replacement material into the chamber to contact the blood-clotting agent; and a means for delivering the bone-substitute material from the chamber to the area to be treated.
A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: Ca10-yGdy(PO4)6-x(SiO4)x(OH)2-x+y where 0 < x < 1.3 and 0 < y < 1.3.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation used to prevent bleeding from
bone. Medical implants, namely bone wax used to prevent bleeding
from bone, wax used as a surgical lubricant and a drug
delivery device.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation used to prevent bleeding from bone; medical implants, namely, bone wax used to prevent bleeding from bone, wax used as a surgical lubricant. Drug delivery device.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopaedic articles; suture materials.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceutical preparation used to prevent bleeding from bone Medical implants, namely bone wax used to prevent bleeding from bone, wax used as a surgical lubricant and a drug delivery device
