Abstract

Provided is a pharmaceutical composition that may be suitable for topical application. The pharmaceutical composition for topical application includes dimethylcurcumin and/or a salt thereof as an active pharmaceutical ingredient in a range of from 0.001% w/w to 0.2% w/w. The pharmaceutical composition for topical application may further include an oil solvent system in an amount of at least 8% w/w.

IPC Classes  ?

• A61K 31/12 - Ketones
• A61K 9/06 - OintmentsBases therefor
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Goods & Services

Facial cream; Cosmetic milks; Non-medicated skin care preparations, namely milky lotions; Cosmetic creams; Skin whitening creams; Body emulsions; Cosmetics; Cosmetic facial masks; Cosmetic preparations for skin care; Shampoos; Non-medicated preparations for the care of scalp; Facial cleanser; Cosmetic preparations for eyelashes; Bath concentrates, namely, bath lotion; Bath gel; Cosmetics for animals; Non-medicated pet shampoos; Non-medicated grooming preparations in the nature of shampoos for animals; Non-medicated bath preparations for animals.

Goods & Services

Facial cream; Cosmetic milks; Non-medicated skin care preparations, namely milky lotions; Cosmetic creams; Skin whitening creams; Body emulsions; Cosmetics; Cosmetic facial masks; Cosmetic preparations for skin care; Shampoos; Non-medicated preparations for the care of scalp; Facial cleanser; Cosmetic preparations for eyelashes; Bath concentrates, namely, bath lotion; Bath gel; Cosmetics for animals; Non-medicated pet shampoos; Non-medicated grooming preparations in the nature of shampoos for animals; Non-medicated bath preparations for animals. Pharmaceutical preparations for human use, namely, for the treatment of viral, metabolic, endocrine, musculoskeletal, cardiovascular, cardiopulmonary, genitourinary, sexual dysfunction, oncological, hepatological, ophthalmic, respiratory, neurological, gastrointestinal, hormonal, dermatological, psychiatric and immune system related diseases and disorders; Reagents for use in diagnostic tests for medical purposes; Medicinal hair growth preparations; Medical dressings; Adhesive skin patches for medical use, namely, medical adhesive tapes; Pharmaceutical preparations for animal skincare; Insecticidal animal washes; Vitamins for animals; Nutritional supplements for pets; Nutritional supplements for cats, dogs; Nutritional supplements for livestock; Dietary supplements for animals; Protein supplements for animals; Medicated after-shave lotions; Medicated shampoos; Medicated toiletry preparations.

Goods & Services

(1) Antiallergic medicines; antidiarrheal medicines; medicines for the treatment of gastrointestinal diseases; medicines for the treatment of mental health disorders; motion sickness medicines; pain relief medicines; diagnostic reagents for medical purposes; medicinal hair growth preparations; bandages for dressings; medical dressing; adhesive dressings; materials for dressing wounds; diagnostic test patches for application to the skin for determining allergic reactions; eye patches for medical purposes; medicated acne treatment patches; transdermal patches for use in the treatment of bruises and sprains; transdermal patches for use in the treatment of heart disease; transdermal patches for use in the treatment of high blood pressure; transdermal patches for use in the treatment of low testosterone levels; transdermal patches for use in the treatment of muscle and joint pain; transdermal patches for use in the treatment of pain relief; transdermal patches for use in the treatment of physical pain; transdermal patches for use in the treatment of trauma and swelling; laxatives for animals; nutritional supplements for animal foodstuffs, for medical purposes; probiotic animal feed; topical anaesthetic spray for animals; topical wound-healing preparations for animals; veterinary pharmaceutical preparations for animals and poultry to give newborn animals and birds a healthy start; vitamins for animals; yeast dietary supplements for animals; insecticidal animal shampoo; insecticidal veterinary washes; medicated after-shave lotions; hair growth shampoo; medicated anti-itch shampoos for pets; pediculicidal shampoos; antiseptic mouthwashes; medicated mouthwashes for pets; mouthwashes for medical purposes. (1) Chemical analysis; consultancy in the field of chemistry; laboratory research in the field of chemistry; research and design in the field of chemistry; cosmetic research; biological cloning services; biological therapeutic research services; bacteriological research; conducting clinical trials for pharmaceuticals and reagents; clinical trials; custom design and development of chemical reagents and biochemical assays; biochemical research and analysis; medical research; research and development in the field of vaccines; research and development in the medical biotechnology field; research and development of vaccines and medicines; research and development services in the field of nutritional supplements; research and development of new products for others; retrieving public documents in the nature of technological research services; technical project studies in the field of pharmacology, pharmaceuticals, and biochemistry; technical writing; industrial research and analysis services in the field of veterinary, pharmacology, pharmaceuticals, and biochemistry; rental of laboratory instruments; scientific laboratory research services in the fields of veterinary, pharmacology, pharmaceuticals, and biochemistry; medical research laboratory services; veterinary laboratories; scientific research in the field of veterinary, pharmacology, pharmaceuticals, and biochemistry; technological consultancy in the field of veterinary, pharmacology, pharmaceuticals, and biochemistry; inspection of goods for quality control for the food industry; design and testing of new products for others; testing, inspection and research of pharmaceuticals, cosmetics and foodstuffs.

Abstract

Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of neuropathy-related disorders and fibrotic diseases. Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of neuropathy-related disorders and fibrotic diseases.

IPC Classes  ?

• C07D 239/91 - Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies
• A61P 11/00 - Drugs for disorders of the respiratory system

Goods & Services

Medicines for human purposes; Reagents for use in diagnostic tests [for medical purposes]; Medicinal hair growth preparations; Materials for dressings; Adhesive patches for medical purposes; Medicine for animals; Animal washes; Medicated after-shave lotions; Medicated shampoos; Medicated toiletry preparations. Chemical analysis; Chemistry services; Cosmetic research; Biological research; Bacteriological research; Conducting clinical trials for pharmaceuticals and reagents; Clinical trials; Research and analysis of medical reagent; Medical research; Research and development services; Research and development of new products for others; Technological research; Conducting technical project studies; Technical writing; Industrial research and analysis services; Rental of laboratory apparatus and instruments; Scientific laboratory services; Scientific research; Technological consultancy; Inspection of goods for quality control; Product quality testing.

Abstract

Histone deacetylases (HDACs) inhibitors are disclosed according to the following structural formula. The moiety A is a benzene ring, optionally substituted. The moiety B is a benzene ring attached at the 1,4 or 1,3 position, or a cyclohexane ring attached at the 1,4 position, optionally substituted. R and Z are further substituents. The HDACs inhibitors possess cytotoxicities to various cancer cell lines. They are useful for treating a tumor associated with deregulation of the activity of histone deacetylases in a subject in need thereof, in one embodiment, the HDACs inhibitors of the invention are useful for treating glioma, breast cancer, colon cancer, target cell lung cancer, adenocarcinoma of the lung, small cell lung cancer, stomach cancer, liver cancer, ovary adenocarcinoma, pancreas carcinoma, prostate carcinoma, promyiocytic leukemia, chronic myelocytic leukemia, or acute lymphocytic leukemia in a subject in need thereof.

IPC Classes  ?

• C07D 239/96 - Two oxygen atoms
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 471/04 - Ortho-condensed systems
• C07D 495/04 - Ortho-condensed systems

Abstract

The invention provides a method for treating a neurodegenerative disorder in a subject in need of such treatment, comprising administrating to said subject a compound with (substituted phenyl)-propenal moiety.

IPC Classes  ?

• A61K 31/12 - Ketones
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention relates to compounds having at least one (substituted phenyl)-propenal moiety. The compounds are useful in treating a subject suffering from an androgen receptor-associated medical condition, e.g., inflammation, acne, alopecia, hirsutism, wound, Spinal and Bulbar Muscular Atrophy (SBMA, Kennedy's Disease), unwanted immune response, immune disorder, or cancer.

IPC Classes  ?

• C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
• C07D 295/192 - Radicals derived from carboxylic acids from aromatic carboxylic acids
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• C07D 295/16 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
• C07C 309/65 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• A61K 31/12 - Ketones
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/255 - Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
• C07C 59/90 - Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
• C07C 69/738 - Esters of keto-carboxylic acids
• C07C 235/74 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
• C07D 277/44 - Acylated amino or imino radicals

Abstract

Histone deacetylases inhibitors (HDACIs) and methods for treating cancer in a subject in need thereof are disclosed. The HDACIs comprise a compound of Formula X. 6 is hydrogen.

IPC Classes  ?

• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• C07D 239/91 - Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

IPC Classes  ?

• A61K 31/12 - Ketones
• C07D 295/192 - Radicals derived from carboxylic acids from aromatic carboxylic acids
• C07C 309/65 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine
• A61K 31/255 - Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof

Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

IPC Classes  ?

• C07C 49/00 - KetonesKetenesDimeric ketenesKetonic chelates
• C07C 69/618 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety having unsaturation outside the six-membered aromatic ring
• C07D 295/192 - Radicals derived from carboxylic acids from aromatic carboxylic acids
• A61K 31/12 - Ketones
• C07C 309/65 - Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• A61K 31/165 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
• A61K 31/426 - 1,3-Thiazoles
• A61K 31/5375 - 1,4-Oxazines, e.g. morpholine

Abstract

Histone deacetylases inhibitors (HDACIs) and compositions comprising the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit are also disclosed. In one aspect, the invention relates to a compound having the structure 6 is hydrogen, or a salt thereof.

IPC Classes  ?

• A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• C07D 239/91 - Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
• C07D 403/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.

IPC Classes  ?

• C07C 49/255 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
• C07C 235/78 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
• C07D 277/46 - Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
• C07D 295/192 - Radicals derived from carboxylic acids from aromatic carboxylic acids
• A61K 31/12 - Ketones

Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, acne, alopecia, hirsutism, a wound, prostate cancer, bladder cancer, liver cancer, breast cancer and Kennedy's disease.

IPC Classes  ?

• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 31/12 - Ketones

Abstract

The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, acne, alopecia, hirsutism, a wound, prostate cancer, bladder cancer, liver cancer, breast cancer and Kennedy's disease.

IPC Classes  ?

• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
• A61K 31/12 - Ketones