Abstract

wherein the first face of each of the first and second fluidic modules is assembled with the face of a block of another fluidic module by contact between the two faces.

IPC Classes  ?

• F16K 11/10 - Multiple-way valves, e.g. mixing valvesPipe fittings incorporating such valvesArrangement of valves and flow lines specially adapted for mixing fluid with two or more closure members not moving as a unit
• F16K 27/00 - Construction of housingsUse of materials therefor

Abstract

The invention relates to a method for purifying a target substance starting from a fluid to be treated which comprises at least one impurity. The method comprises treatment of a stream of the fluid to be treated using a chromatography step in a first separation unit, collection of a fraction enriched with the target substance in a first tank, and viral inactivation of the fraction enriched with the target substance. The viral inactivation comprises passing the fraction enriched with the target substance through a second separation unit, passing a viral inactivation solution through the second separation unit, mixing, and collecting the mixture in the second tank to obtain a fraction depleted of active virus. The method further comprises treatment of the fraction depleted of active virus using a chromatography step in the second separation unit and collection of a fraction more enriched with the target substance.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• B01J 47/026 - Column or bed processes using columns or beds of different ion exchange materials in series
• B01J 49/85 - Controlling or regulating devices therefor

Abstract

The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of: injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups; performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/185 - Magnoliopsida (dicotyledons)
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• G01N 30/02 - Column chromatography
• G01N 30/06 - Preparation

Abstract

The invention relates to an apparatus for purification of biomolecules, comprising an injection device comprising an injection channel provided with at least one inlet for a precipitation agent composition and a plurality of outlets on the external surface of the injection channel and a mixing device comprising a mixing channel with at least one main inlet for a composition to be purified and at least one main outlet, and a plurality of secondary inlets, wherein the injection device and the mixing device are coupled such that each of the plurality of outlets of the injection device is connected to a respective secondary inlet of the mixing channel. The invention further relates to a set comprising the apparatus, a composition comprising at least one biomolecule and at least one impurity, and a composition comprising at least one precipitation agent, and to a method for purification of biomolecules using the apparatus.

IPC Classes  ?

• C07K 1/30 - ExtractionSeparationPurification by precipitation
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• B01D 21/01 - Separation of suspended solid particles from liquids by sedimentation using flocculating agents

Abstract

The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of:injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups;performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07D 311/80 - DibenzopyransHydrogenated dibenzopyrans

Abstract

The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of: injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups; performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.

IPC Classes  ?

• A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
• A61K 36/185 - Magnoliopsida (dicotyledons)
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• B01D 15/32 - Bonded phase chromatography, e.g. with normal bonded phase, reversed phase or hydrophobic interaction
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• G01N 30/02 - Column chromatography
• B01D 1/18 - Evaporating by spraying to obtain dry solids
• G01N 30/06 - Preparation

Abstract

The invention relates to a method for chromatographic separation, comprising at least one step of elution of species held on a stationary phase by means of an eluent, followed by a step of moving the eluent in contact with the stationary phase by means of a compressed gas. Preferably, the movement step takes place after a step of elution of the product(s) of interest and/or after a step of regeneration of the stationary phase.

IPC Classes  ?

• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
• B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns

Goods & Services

Separation machines for separating the contents of pharmaceutical and biopharmaceutical compositions by implementing chromatography processes on analytical and industrial scales for the biopharmaceutical industry Chromatography apparatus for laboratory use with the pharmaceutical and biopharmaceutical industries; Chromatography apparatus for laboratory use for sequential chromatography, for multiple-column chromatography, for affinity chromatography, said apparatus intended for these same industries; Chromatography laboratory apparatus for multiple-column sequential chromatography

Abstract

The invention relates to a method for chromatographic separation, comprising at least one step of elution of species held on a stationary phase by means of an eluent, followed by a step of moving the eluent in contact with the stationary phase by means of a compressed gas. Preferably, the movement step takes place after a step of elution of the product(s) of interest and/or after a step of regeneration of the stationary phase.

IPC Classes  ?

• B01D 15/20 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
• B01D 15/40 - Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent

Goods & Services

Chemical products for industrial use; chromatography for fluids, particularly for preparatory chromatography, analytical chromatography, liquid, semi-liquid or gas chromatography; eluants for chromatography, particularly for preparatory chromatography, analytical chromatography, liquid, semi-liquid or gas chromatography. Chromatography apparatus and instruments; laboratory apparatus for preparatory chromatography, analytical chromatography, liquid, semi-liquid or gas chromatography. Evaporators; drying apparatus.

Abstract

The invention pertains to a method for purifying a first fatty acid, preferably polyunsaturated, based on an initial mixture further comprising at least one second fatty acid, optionally a third fatty acid, and optionally a fourth fatty acid, the method comprising: a first step of liquid-phase chromatographic purification, based on the initial mixture, carried out in a first chromatographic separation unit, making it possible to retrieve both a first flow enriched with the first fatty acid and a flow enriched with the second fatty acid; optionally, a second step of liquid-phase chromatographic purification, based on the first flow enriched with the first fatty acid, carried out in a second chromatographic separation unit, making it possible to retrieve both a second flow enriched with the first fatty acid and a flow enriched with the third fatty acid; optionally, a third step of liquid-phase chromatographic separation, based on the third flow enriched with the first fatty acid, carried out in a third chromatographic separation unit, making it possible to retrieve both a third flow enriched with the first fatty acid and a flow enriched with a fourth fatty acid; at least one of the first chromatographic separation unit, the second chromatographic separation unit and the third chromatographic separation unit being a static-bed, single-column chromatographic separation unit with steady-state recirculation.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• C07C 57/03 - Monocarboxylic acids

Abstract

The invention concerns a method for purifying a first fatty acid, particularly a first polyunsaturated fatty acid, based on an initial mixture further comprising at least one second fatty acid and one third fatty acid, the method comprising at least: a first step of liquid-phase chromatographic separation, based on the initial mixture, making it possible to retrieve both a first flow enriched with the first fatty acid and a flow enriched with the second fatty acid; a second step of liquid-phase chromatographic separation, based on the first flow enriched with the first fatty acid, making it possible to retrieve both a second flow enriched with the first fatty acid and a flow enriched with the third fatty acid, the second step of chromatographic separation being carried out in a static-bed chromatographic separation unit.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• C07C 51/47 - SeparationPurificationStabilisationUse of additives by solid-liquid treatmentSeparationPurificationStabilisationUse of additives by chemisorption
• C07C 57/03 - Monocarboxylic acids

Goods & Services

Chromatography apparatus for industrial purposes

Abstract

A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.

IPC Classes  ?

• B01D 15/08 - Selective adsorption, e.g. chromatography

Abstract

The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23,) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.

IPC Classes  ?

• B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
• G01N 30/46 - Flow patterns using more than one column

Abstract

The invention relates to a method for separating fractions of a mixture to be separated including the steps of providing a device comprising at least two chromatography columns mounted in series, discontinuously injecting a mixture to be separated, in a single point of the device, discontinuously drawing off the fraction enriched in the product of interest, in a single point of the device, and injecting eluents in each column and displacing the points for injection eluents, the eluents having a different eluting power. The method allows efficient separation which is simple to perform.

IPC Classes  ?

• G01N 30/02 - Column chromatography

Abstract

The invention concerns a method for separating fractions of a mixture using a chromatography device. The method includes the following steps: controlling in one node of the device, the history of a specific variable of the fractions of the mixture to be separated; detecting one characteristic point of the history, the characteristic point being between two successive steps of fraction collecting; comparing the position of the characteristic point relative to a target position; adjusting the amount of mobile phase modifying the position of the characteristic point to cause the position of the characteristic point to coincide with the target position. The invention also concerns a device for implementing the method. The method enables the operation of the device to be automatically set.

IPC Classes  ?

• B01D 15/08 - Selective adsorption, e.g. chromatography

Goods & Services

Absorbent synthetic resins in granular form for molecule separation by chromatography. Equipment and devices (machines) for separation by using analytic and industrial scale chromatography for use in the pharmaceutical and biopharmaceutical industries. Chromatography apparatus and instruments for use in the pharmaceutical and biopharmaceutical industries; sequential chromatography apparatus and instruments, multicolumn chromatography apparatus and instruments, affinity chromatography apparatus and instruments, ail for use in the pharmaceutical and biopharmaceutical industries; laboratory apparatus for sequential multicolumn chromatography.

Abstract

A process is disclosed for separating biomolecules from an aqueous solution containing the biomolectules and impurities, having different affinities and/or interactions with a solid support. The solution is passed over a fixed bed of chromatographic resin containing at least three zones, with flow of liquid being arranged between adjacent zones and between a last and first zone. Each of several sequences includes at least an adsorption stage, a rinsing stage, or a desorption stage, with each subsequent sequence being carried out by a downstream displacement of fronts in the zones by approximately the same increment before the periodical displacement of the introduction and withdrawal points.

IPC Classes  ?

• B01D 15/08 - Selective adsorption, e.g. chromatography

Goods & Services

Separation machines for implementing chromatography processes on analytical and industrial scales for the biopharmaceutical industry. Chromatography apparatus and instruments for the pharmaceutical and biopharmaceutical industries, apparatus, instruments for sequential chromatography, for multiple-column chromatography, for affinity chromatography, said apparatus and instruments intended for these same industries, laboratory apparatus for multiple-column sequential chromatography.

Goods & Services

Fluids for use in chromatography and crystallography; chemical products for use in chromatography and crystallography; solvents for use in chromatography and crystallography. Laboratory apparatus for use in chromatography; laboratory apparatus for use in crystallography; evaporators, driers, storage devices for use in chromatography and crystallography; scientific apparatus and instruments, liquid and gas chromatography columns. Chromatography apparatus and instruments; crystallography apparatus and instruments. Treatment of chemical products, chromatographic procedures for chemical product separation. Studies, design of new products and development (design) in the field of chromatography; studies, design of new products and development (design) in the field of crystallography; design of equipment in connection with mixture fractionation by chromatographic procedures; design of equipment in connection with mixture fractionation by crystallographic procedures; research work in the field of chromatography; research work in the field of crystallography.

Goods & Services

LABORATORY APPARATUS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, COLUMNS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY; EVAPORATORS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY; LABORATORY STORAGE DEVICES FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, LABORATORY STORAGE TUBES [ APPARATUS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY, NAMELY, DRYERS FOR CHROMATOGRAPHY AND CRYSTALLOGRAPHY ]

Goods & Services

CUSTOM MANUFACTURE OF GENERAL PRODUCTS IN THE FIELD OF CHROMATOGRAPHY AND CRYSTALLOGRAPHY RESEARCH AND DESIGN IN THE FIELD OF CHROMATOGRAPHY AND CRYSTALLOGRAPHY; DESIGN OF APPARATUS FOR CHROMATOGRAPHIC AND CRYSTALLOGRAPHIC FRACTIONATION OF MIXES

Goods & Services

Fluids for chromatography and crystallography; chemicals used in chromatography and crystallography. Laboratory apparatus for chromatography; laboratory apparatus for crystallography; evaporators, dryers, storage devices and solvents for chromatography and crystallography. Apparatus and instruments for chromatography; apparatus and instruments for crystallography. Studies, design and creation in the field of chromatography; studies, design and creation in the field of crystallography; design of apparatus for separating mixtures by chromatography processes; design of apparatus for splitting mixtures by crystallography processes; all research work in the area of chromatography, all research work in the area of crystallography.

Goods & Services

Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry. Scientific, measuring, signalling, checking (supervision) and teaching apparatus and instruments. Treatment of materials during the manufacturing process of all types of goods other than buildings; processing of agricultural products for others (wine-making, distillation, threshing, fruit crushing, milling). Surveying, professional consultancy and construction drafting, non-business; chemical engineering, material testing; laboratory work.

Goods & Services

liquid chromatography apparatus

Goods & Services

Appareils pour la chromatographie préparative.