Abstract

A process for the photolytic chlorination of 3-halopyridine with molecular chlorine The present invention relates to a process for the chlorination of 3-halopyridine with molecular chlorine in the presence of water under UV light irradiation in the vapor phase. The present invention further relates to a multi-step process for producing 5-chloro-3,6-difluoropyridin-2-amine.

IPC Classes  ?

• C07D 213/61 - Halogen atoms or nitro radicals
• C07D 213/73 - Unsubstituted amino or imino radicals

Goods & Services

Chemicals used in industry, science, the manufacture and production of pharmaceutical preparations; catalysts; industrial chemicals; dehydrating preparations for industrial purposes; salts for galvanic cells; agricultural chemicals, except fungicides, herbicides, insecticides and parasiticides; chemical additives to insecticides; chemical additives to fungicides; horticultural chemicals, except fungicides, herbicides, insecticides and parasiticides; chemicals for use in forestry, except fungicides, herbicides, insecticides and parasiticides; chemical preparations for scientific purposes, other than for medical or veterinary use; chemical reagents, other than for medical or veterinary purposes. Pharmaceutical substances, compositions, preparations and products; antiseptics; pharmaceutical preparations; chemico-pharmaceutical preparations; germicides; chemical preparations for pharmaceutical purposes; chemical preparations for medical purposes; chemical reagents for medical or veterinary purposes; preparations for destroying noxious animals; biocides; Insecticides; herbicides / weedkillers / preparations for destroying noxious plants; herbicides; pesticides; germicides for agriculture. Business management services and consultancy relating to business management, including in relation to the manufacturing and supply chain for the pharmaceutical, chemical and biotechnology sectors. Scientific and technological services and research and design relating thereto; advisory and consultancy services for the chemical industry; chemical analysis and research services; consultancy services and advice concerning chemical processes and chemical synthesis, their design and improvement, including processes and plant for the manufacture of pharmaceutical components and pharmaceutical intermediates, fine chemicals, industrial chemicals, catalysts and the synthesis of fine organic chemicals; design and validation of plant and equipment for the pharmaceutical, chemical and biotechnology sectors.

Abstract

The present invention provides a method for preparing o(p)-hydroxybenzonitrile. o(p)-hydroxybenzonitrile is an important fine chemical intermediate used in the fields of medicine and pesticide. In the present invention, o(p)-halogenated benzonitrile, used as raw material, reacts with 5-50% anhydrous alcohol solution of alkali metal alkoxide in the reaction mole ratio of 1:2-5 for 1-24 hours at the reaction temperature of 100-250 ℃ and under the reaction pressure of 0.5-6 MPa. After reducing the temperature, cooling, and distilling under reduced pressure to remove the solvent, hydrochloric acid is added to acidify, and o(p)-hydroxybenzonitrile solid is obtained. In the preparation method of the present invention, the raw material used is cheap, the reaction steps are short, the operation is safe, the yield is high, and the byproduct is less. It is suitable for commercial production.

IPC Classes  ?

• C07C 255/53 - Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
• C07C 253/30 - Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Abstract

Provided is a method for preparing 2,5-dimethylphenylacetic acid，wherein p-xylene is mixed with paraformaldehyde and concentrated hydrochloric acid in a solvent of ion liquid to obtain 2,5-dimethyl benzyl chloride by the chloromethylation reaction. Then, 2,5-dimethyl benzyl chloride is introduced into a reactor with an acid binding agent and a solvent, the carbonylation and hydrolysis reaction is conducted in the presence of a catalyst to obtain 2,5-dimethylphenylacetic acid. The present process has new route, less synthesis steps, simple operation, lower cost, increased yield, and is friendly to the environment. Therefore, the method is suitable for industrial production.

IPC Classes  ?

• C07C 51/10 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reaction with carbon monoxide
• C07C 57/30 - Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

Abstract

Disclosed is a method for preparing 2,3-dichloropyridine, which comprises the following steps: (1). chlorination: reacting 2,6-dichloropyridine with chlorine gas in the presence of a catalyst to obtain 2,3,6-trichloropyridine; (2). hydrogenation: hydrogenating 2,3,6-trichloropyridine in an organic solvent in the presence of an acid-binding agent and a catalyst; (3). post-processing: cooling the aforementioned reaction mixture, adding water to dissolve the acid-binding agent hydrochloride, standing to separate the water layer after filtrating, extracting the organic solvent layer with a hydrous acid at least three times, combining the hydrous acid layer, adding water to dilute to separate the solid, filtering and drying it to obtain 2,3-dichloropyridine.

IPC Classes  ?

• C07D 213/61 - Halogen atoms or nitro radicals

Abstract

Chiral amino compounds, methods of preparation and uses thereof. Tamiflu can be obtained from the said compounds. Multi-substituted chiral tetrahydropyrrolyl amine which can be used as intermediate compounds of medicament can also be produced by the said compounds.

IPC Classes  ?

• C07D 213/73 - Unsubstituted amino or imino radicals
• C07D 209/48 - Iso-indolesHydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
• C07C 233/52 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
• C07C 231/12 - Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
• C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• C07D 401/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/215 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
• A61P 31/16 - Antivirals for RNA viruses for influenza or rhinoviruses

Abstract

A method for preparing the linezolid (compound 1), which comprises the steps of: (1) carrying out the debenzyl reaction of compound 4 in solvent, to obtain the compound 5 or its acetate; (2) carrying out the acetylation reaction in the amino of the compound 5 or its acetate obtained in step (1) in solvent to obtain the compound 1. The intermediates to prepare the compound 1 and the acetate of compound 5. The present preparation method is easy to obtain the chiral materials and the chiral materials are cheap, the process and the post treatment are simple, the intermediate products and the end product are easy to be purified, the total yield is high, their purities are also high, this preparation method is easy to be used in the industry manufacture.

IPC Classes  ?

• C07D 263/20 - Oxygen atoms attached in position 2

Abstract

Disclosed is a method for preparing 3-bromo-5-chlorophenol showed as formula (1), which includes the following step: hydrolyzing compound (3) in acidic medium to obtain compound (1), in which X- is Cl-, Br-, HSO4- or NO3-. The preparing method has advantage of low cost, easy obtained raw material, convenient handling, easy purified product, and the method is easy to be scale up. Further more, higher yield and purity can be obtained.

IPC Classes  ?

• C07C 37/045 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis by substitution of a group bound to the ring by nitrogen
• C07C 245/20 - Diazonium compounds
• C07C 209/36 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings

Abstract

Preparation methods of aminomethyl biphenyl tetrazole compounds of formula I or their salts and salts of formula II comprise that intermediates of formula III are reduced by reducing agents in an inert organic solvent to obtain aminomethyl biphenyl tetrazole compounds or their salts (formula I), followed by acidification to obtain their salts (formula II); alternatively, intermediates of formula III are reduced in acidic condition to obtain their salts directly (formula II), in which M is hydrogen or alkali metals or C3-C18 tertiary amine salts, X is Cl,Br,HSO4 or CH3COO. Intermediates of formula III and their preparation methods. The present methods have advantages of abundance source for the raw materials, low cost, simple operation for synthesizing steps, mild reaction conditions, easy purification of products, high purity of products such as 99.5% and high yield. So the present methods are suitable for both small scale in the laboratory and industrial process.

IPC Classes  ?

• C07D 257/04 - Five-membered rings