CLOSURE DEVICES ESPECIALLY ADAPTED TO ENSURE PROPER CLOSURE OF BIOLOGICAL SPECIMEN CONTAINERS AND BIOLOGICAL SPECIMEN COLLECTION KITS INCLUDING THE SAME
Closure devices and kits allow closure of an open-ended container and provide a visible indication of closure torque. The closure device will include an outer cap defining a torque indicator window, an inner cap nested within the outer cap and a torque indicator disc positionally fixed to an upper surface of the inner cap and having at least two different indicia regions angularly adjacent to one another. The outer and inner caps are in mechanical interference fit with one another such that turning movement applied to the closure device allows the outer and inner caps to be turned as a unit and threadably coupled onto a threaded container until the inner cap is frictionally engaged with an edge of the container. Thereafter, continued turning movement of the outer cap relative to the inner cap causes angular displacement of the indicator window relative to the torque indicator to thereby provide a visible indication through the indicator window of an indicia region indicative of sufficient closure torque.
B65D 50/04 - Closures with means for discouraging unauthorised opening or removal thereof, with or without indicating means, e.g. child-proof closures openable or removable by the combination of plural actions requiring the combination of simultaneous actions, e.g. depressing and turning, lifting and turning, maintaining a part and turning another one
B65D 41/04 - Threaded or like caps or cap-like covers secured by rotation
B65D 41/06 - Threaded or like caps or cap-like covers secured by rotation with bayonet cams
B65D 55/02 - Locking devicesMeans for discouraging or indicating unauthorised opening or removal of closure
B67B 3/20 - Closing bottles, jars, or similar containers by applying caps by applying and rotating preformed threaded caps
2.
CLOSURE DEVICES ESPECIALLY ADAPTED TO ENSURE PROPER CLOSURE OF BIOLOGICAL SPECIMEN CONTAINERS AND BIOLOGICAL SPECIMEN COLLECTION KITS INCLUDING THE SAME
Closure devices and kits allow closure of an open-ended container and provide a visible indication of closure torque. The closure device will include an outer cap defining a torque indicator window, an inner cap nested within the outer cap and a torque indicator disc positionally fixed to an upper surface of the inner cap and having at least two different indicia regions angularly adjacent to one another. The outer and inner caps are in mechanical interference fit with one another such that turning movement applied to the closure device allows the outer and inner caps to be turned as a unit and threadably coupled onto a threaded container until the inner cap is frictionally engaged with an edge of the container. Thereafter, continued turning movement of the outer cap relative to the inner cap causes angular displacement of the indicator window relative to the torque indicator to thereby provide a visible indication through the indicator window of an indicia region indicative of sufficient closure torque.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
3.
CLOSURE DEVICES ESPECIALLY ADAPTED TO ENSURE PROPER CLOSURE OF BIOLOGICAL SPECIMEN CONTAINERS AND BIOLOGICAL SPECIMEN COLLECTION KITS INCLUDING THE SAME
Closure devices and kits allow closure of an open-ended container and provide a visible indication of closure torque. The closure device will include an outer cap defining a torque indicator window, an inner cap nested within the outer cap and a torque indicator post positionally fixed to and extending upwardly from an upper surface of the inner cap in alignment with the indicator window of the outer cap. The outer and inner cap are mechanically coupled to one another such that turning movement applied to the closure device allows the outer and inner caps to be turned as a unit and threadably coupled onto the threaded open-ended container until the inner cap is frictionally engaged with an edge of the container whereupon continued turning movement of the outer cap relative to the inner cap causes coaxial downward displacement of the outer cap relative to the inner cap. Such axial downward displacement thereby causes the indicator post of the inner cap to protrude upwardly through the indicator window of the outer cap thereby indicating sufficient closure torque for the closure device.
Durable, pigmented and transparent, inorganic-organic hybrid sol, gel coating materials are provided which mitigate galvanic corrosion of metal substrates. The coating materials are generally an acid catalyzed condensation reaction product comprised of an organic polymeric silane (e.g., a polyol functionalized with a silane through a urethane linkage or a polyamine functionalized with a silane through a urea linkage, such as isocyanatopropyltrimethoxysilane or isocyanatopropyltriethoxysilane), an inorganic metal alkoxide (e.g., silicon alkoxides such as tetraethoxysilane or tetramethoxysilane) and metal oxide nano particles such as silica (SiCte) which may optionally include other additives such as color agents and/or corrosion inhibitors.
C09D 183/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C09D 183/16 - Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon onlyCoating compositions based on derivatives of such polymers in which all the silicon atoms are connected by linkages other than oxygen atoms
Wearable posture support devices include an adjustable waist belt having a lumbar support region, a longitudinally elastic back strap having a lower end attached to the lumbar support region of the waist belt, and right and left bilateral tension strap elements each having an upper end attached to an upper end of the elastic back strap and a lower end adapted for attachment to the lumbar support region of the waist belt adjacent the lower end of the back strap. The right and left bilateral tension strap elements are provided with an upper tensioning system for applying an adjustable longitudinally extensible tension force onto the elastic back strap which thereby provides posture support to a user when the device is worn
Provided herein are pharmaceutical compositions comprising surface functionalized carbon nanotube and an active agent. The active agent can be attached to the carbon nanotube covalently or noncovalently. Also provided are methods of preparing the pharmaceutical compositions and methods of use thereof.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/59 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 39/385 - Haptens or antigens, bound to carriers
Provided herein are pharmaceutical compositions comprising chitosan based nanoparticles, such as those having a core-shell structure, which can be configured for layer-by-layer delivery of active agent(s).
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
Processes are provided which pyrolytically extract hydrochloric acid from a magnesium ion-rich salt mixture. In this regard, a supply of the magnesium ion-rich salt mixture (e.g., bittern) may be directed to a pyrolytic chamber where it is contacted with heated gas (e.g., combustion flue gas) at a sufficient temperature and for a sufficient time to form a vapor product stream comprised of hydrochloric acid and an insoluble pyrolyzed mixed salt stream comprised of magnesium hydroxide and sodium sulfate decahydrate. The solid pyrolyzed mixed salt stream may be separated into separate product streams comprising the insoluble magnesium hydroxide and remaining soluble salt fractions, while the vapor product stream of hydrochloric acid from the pyrolytic chamber may be condensed form an aqueous HCl solution. The magnesium ion rich salt mixture may be dehydrated prior to pyrolysis to achieve magnesium ions in a tetrahydrate state or lower (e.g., a monohydrate to a trihydrate state).
G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
10.
SURFACE ACTIVATION OF MATERIALS AND MICROARRAY PRINTING FOR USE IN BIOLOGICAL ANALYSIS
Provided herein are methods of surface functionalization, array construction, and/or blocking as well as substrates that are surface functionalized and blocked from non-specific bindings. Also provided herein are blocking solutions, blocking agents, and kits comprising the same. Further provided are methods of using functionalized and blocked surfaces for analyzing samples, such as in an SPR analysis.
G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
11.
SOL-GEL COATING FORMULATIONS AND METHODS TO MITIGATE GALVANIC CORROSION
Durable, pigmented and transparent, inorganic-organic hybrid sol¬ gel coating materials are provided which mitigate galvanic corrosion of metal substrates. The coating materials are generally an acid catalyzed condensation reaction product comprised of an organic polymeric silane (e.g., a polyol functionalized with a silane through a urethane linkage or a polyamine functionalized with a silane through a urea linkage, such as isocyanatopropyltrimethoxysilane or isocyanatopropyltriethoxysilane), an inorganic metal alkoxide (e.g., silicon alkoxides such as tetraethoxysilane or tetramethoxysilane) and metal oxide nano particles such as silica (SiCte) which may optionally include other additives such as color agents and/or corrosion inhibitors.
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
12.
SOL-GEL COATING FORMULATIONS AND METHODS TO MITIGATE GALVANIC CORROSION
Durable, pigmented and transparent, inorganic-organic hybrid sol¬ gel coating materials are provided which mitigate galvanic corrosion of metal substrates. The coating materials are generally an acid catalyzed condensation reaction product comprised of an organic polymeric silane (e.g., a polyol functionalized with a silane through a urethane linkage or a polyamine functionalized with a silane through a urea linkage, such as isocyanatopropyltrimethoxysilane or isocyanatopropyltriethoxysilane), an inorganic metal alkoxide (e.g., silicon alkoxides such as tetraethoxysilane or tetramethoxysilane) and metal oxide nano particles such as silica (SiCte) which may optionally include other additives such as color agents and/or corrosion inhibitors.
C23C 18/12 - Chemical coating by decomposition of either liquid compounds or solutions of the coating forming compounds, without leaving reaction products of surface material in the coatingContact plating by thermal decomposition characterised by the deposition of inorganic material other than metallic material
13.
Advanced single vacuum bag process and assembly for polymer composite manufacturing and repair
Advanced single vacuum bag (ASVB) fabrication methods and assemblies are provided to manufacture and repair polymer composites whereby a rigid check plate is mounted over an uncured laminate by a thermally collapsible check plate stand. The check plate stand thereby maintains a gap between the check plate and the uncured laminate during first stage processing conditions, yet is capable of thermally collapsing during subsequent second stage processing conditions to thereby allow the check plate to fall into compressive contact with the uncured laminate After the check plate collapses onto the uncured laminate, the compressive force of the check plate will be transferred to the laminate to consolidate the laminate as desired and thereby form an at least partially cured polymer composite structure of high quality.
B29C 70/34 - Shaping by lay-up, i.e. applying fibres, tape or broadsheet on a mould, former or coreShaping by spray-up, i.e. spraying of fibres on a mould, former or core and shaping or impregnating by compression
B29C 70/54 - Component parts, details or accessoriesAuxiliary operations
B29K 63/00 - Use of epoxy resins as moulding material
The novel flexible electrodes disclosed herein utilize the low bending stiffness of electrospun nanofiber mats to achieve the material properties required for surgical implantation and sustained bidirectional communication with peripheral nerves without compromising electronic functionality. According to certain embodiments disclosed herein, implantable neural electrode probes are provided which comprise a polymeric substrate having proximal and distal ends, an electrode interface at the proximal end of the substrate; at least one neural contact at the distal end of the substrate; and electrically conductive traces formed on the fibrous substrate providing electrical communication between the at least one neural contact and the electrode interface, wherein the substrate comprises a nonwoven mass of polymeric nanofibers.
Dual phase membranes include a porous support providing a solid phase having a matrix of connected pores, and a liquefiable ion transport phase within the pores of the porous support. The ion transport phase is formed of at least one alkali metal hydroxide, and at least one oxide ion transport agent providing a source of ions selected from the group consisting of borate ions, nitrate ions, phosphate ions, vanadate ions, niobate ions or sulfate ions. The at least one alkali metal hydroxide may be selected from the group consisting of NaOH, KOH, LiOH, RbOH, CsOH and mixtures thereof. The oxide ion transport agent is preferably present in the ion transport phase in an amount between about 1 to about 30 molar %. Substantially lower operational temperatures may be realized when the membrane is used to separate CO2 from a feed gas.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
Medical dressings include a non-woven polymeric nanofiber mat embedded within a chitosan hydrogel matrix. The dressings may be obtained by electro spinning of polymeric nanofibers and thereafter incorporating a chitosan hydrogel into interstices of the mat by vacuum or positive pressure assistance. The resulting medical dressings may be optically transparent (e.g., at least about 50% up to about 95% light transmittance), flexible, and mechanically robust. The dressings may also incorporate self-adhesion promoters to allow self-adhesion to biological tissue, e.g., ocular surfaces, and/or therapeutic agents which are capable of delivering therapeutics (e.g. stem cells, drugs and the like) to the tissue surface. The dressings are especially useful as ocular bandages for the treatment and repair of ocular wounds.
Biologically acceptable surgical barrier materials are comprised of a polyelectrolytic complex of chitosan and sodium alginate. The chitosan is deacetylated in an amount between about 40 to about 60% and has a molecular weight (Mw) between 50,000 and 375,000 g/mol. The barrier materials may be formed by mixing a two-component material system whereby one component comprises the chitosan and a second component comprises the sodium alginate and directing such a mixture (e.g., via air-assisted spray nozzle) toward a surgical site in need of the material. A polyelectrolytic complex of the chitosan and sodium alginate will thereby form in situ. Suitable ionic cross-linkers may be provided in the individual components, e.g., calcium chloride with the chitosan component and sodium tripolyphosphate with the sodium alginate component.
Biological specimen recovery materials include cellulose acetate nanofibers that are capable of dissolution upon contact with a liquid comprising a dissolution effective amount (e.g., between about 1 to about 10M) guanidinium isothiocyanate (GITC). Kits containing the materials (e.g., in the form of a swab, filtration media or surface wipe) and a dissolution liquid containing the dissolution effective amount of guanidinium isothiocyanate (GITC) are also provided.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Simulated blood, simulated blood concentrate, kits comprised of simulated blood, all for purposes of medical training, first responder training, scenario training and educational simulation.
(2) Simulated hemostatic gauze for purposes of medical training, first responder training, scenario trainingand educational simulation,simulated blood clotting solution for purposes of medical training, first respondertraining, scenario training and educational simulation, kits comprised of simulated hemostatic gauze andsimulated blood clotting solution, all for purposes of medical training, first responder training, scenariotraining and educational simulation.
(3) Simulated hemorrhage control and wound treatment training device, for purposes of medical training, first responder training, scenario training and educational simulation.
20.
Apparatus, systems, and methods for determining nonlinear properties of a material to detect early fatigue or damage
An inspection apparatus detects one or more characteristics of a material sample and includes a transmitter to transmit an initial signal to the material sample, and a receiver to receive a detected signal from the material sample associated with the initial signal. The detected signal has at least a first harmonic signal component and a second harmonic signal component. Data processing circuitry determines a resonant frequency of the first harmonic signal component and an amplitude of the first harmonic signal component at the resonant frequency, and filters the detected signal using a first filter signal having a frequency corresponding to the first harmonic signal component and a second filter signal having a frequency corresponding to the second harmonic signal component. A frequency analysis is performed in the frequency domain on the filtered first and second signals to determine corresponding first and second amplitudes. The first and second amplitudes may be compensated for nonlinearity. One or more nonlinear parameters are determined based on the first and second amplitudes. A user interface communicates one or more characteristics of the material sample based on the first and second compensated amplitudes.
G01N 29/44 - Processing the detected response signal
G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
G01N 29/42 - Detecting the response signal by frequency filtering
21.
Measurement systems and methods for corrosion testing of coatings and materials
A measurement system permits environmental, corrosion damage, and mechanical property measurements to assess protection properties of coatings. The system includes one or more multi-sensor panels, each multi-sensor panel having sensors for assessing coating barrier properties, free corrosion, and galvanic corrosion. Each multi-sensor panel is installed on a test rack that contains electronics for sensor excitation and sensor data acquisition throughout a corrosion test. Sensor data is collected, stored, and communicated to a base station. A network of multiple test racks can be supported by a base station to compare the performance of different coatings and material combinations simultaneously. The test racks can be used in accelerated atmospheric corrosion tests, outdoor test sites, or application service environments. Measurements of the capacity of a coating to maintain barrier properties, prevent free corrosion, galvanic corrosion, and environment-assisted cracking can be used to develop, select, and predict service performance of coatings.
G01N 3/02 - Investigating strength properties of solid materials by application of mechanical stress Details
G01N 3/06 - Special adaptations of indicating or recording means
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 3/20 - Investigating strength properties of solid materials by application of mechanical stress by applying steady bending forces
G01N 19/04 - Measuring adhesive force between materials, e.g. of sealing tape, of coating
G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
22.
Measurement systems and methods for corrosion testing of coatings and materials
A measurement system permits environmental, corrosion damage, and mechanical property measurements to assess protection properties of coatings. The system includes one or more multi-sensor panels, each multi-sensor panel having sensors for assessing coating barrier properties, free corrosion, and galvanic corrosion. Each multi-sensor panel is installed on a test rack that contains electronics for sensor excitation and sensor data acquisition throughout a corrosion test. Sensor data is collected, stored, and communicated to a base station. A network of multiple test racks can be supported by a base station to compare the performance of different coatings and material combinations simultaneously. The test racks can be used in accelerated atmospheric corrosion tests, outdoor test sites, or application service environments. Measurements of the capacity of a coating to maintain barrier properties, prevent free corrosion, galvanic corrosion, and environment-assisted cracking can be used to develop, select, and predict service performance of coatings.
G01N 3/02 - Investigating strength properties of solid materials by application of mechanical stress Details
G01N 3/06 - Special adaptations of indicating or recording means
G01N 17/02 - Electrochemical measuring systems for weathering, corrosion or corrosion-protection measurement
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
G01N 27/04 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
G01N 3/20 - Investigating strength properties of solid materials by application of mechanical stress by applying steady bending forces
G01N 19/04 - Measuring adhesive force between materials, e.g. of sealing tape, of coating
G01N 3/08 - Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
23.
Fluid resistant, high performance reactive hot melt sealant and/or adhesive compositions
A reactive hot melt (RHM) composition is provided as a mixture of a urethane prepolymer which is a reaction product of at least one crystallizable polyol, a perfluoropolyether polyol, and at least one isocyanate, a filler material, and a teachable plasticizer consisting of an aliphatic ester of a carboxylic acid.
C08G 18/12 - Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step using two or more compounds having active hydrogen in the first polymerisation step
A sensing device includes a pair of contactless electrodes for placement on a coating on a surface of a structure or within or between one or more coatings on or over the surface of the structure. The electrodes function as sensors when activated to generate a current flow through the electrodes at multiple different frequencies. The sensing device also includes contactless control circuitry co-located with or separate from the electrodes that transmits impedance data generated from the activated electrodes. The impedance data is associated with corrosion condition information of the structure and/or the one or more coatings. A data collection system and display system useable with the sensing device are also described.
A corrosivity associated with each of multiple locations near, on, or within a structure exposed to an environment that can corrode the structure is determined. Each of multiple sensor nodes is mounted at a corresponding one of the locations and measures environmental sensor information using one or more environmental sensors and corrosion sensor information using one or more corrosion sensors. The environmental sensor information is processed to obtain for the sensing node a first atmospheric corrosivity category value in accordance with a corrosivity classification system, and the corrosion sensor information is processed to obtain a second atmospheric corrosivity category value for the sensing node in accordance with the corrosivity classification system. One or more of the first and second atmospheric corrosivity category values is provided for use in determining a corrosion classification value for each of the locations.
G01N 7/14 - Analysing materials by measuring the pressure or volume of a gas or vapour by allowing the material to emit a gas or vapour, e.g. water vapour, and measuring a pressure or volume difference
Durable, transparent, inorganic-organic hybrid hydrophobic coating materials for glass, metal or plastic substrates are provided. The coating materials are generally an acid catalyzed condensation reaction product comprised of an organic polymeric silane (e.g., a polyol functionalized with a silane through a urethane linkage or a polyamine functionalized with a silane through a urea linkage, such as isocyanatopropyltrimethoxysilane or isocyanatopropyltriethoxysilane), an inorganic metal alkoxide (e.g., silicon alkoxides such as tetraethoxysilane or tetramethoxysilane) and a fluorinated silane (e.g., (3,3,3-trifluoropropyl)trimethoxysilane or nonafluorohexyltrimethoxysilane).
C09K 3/18 - Materials not provided for elsewhere for application to surface to minimize adherence of ice, mist or water theretoThawing or antifreeze materials for application to surfaces
27.
Medical training kits and methods to simulate treatment of uncontrolled hemorrhage
Medical training kits and methods include a simulated liquid blood which simulates mammalian whole blood and a simulated hemostatic component. The simulated liquid blood includes a gellable component, and a simulated hemostatic component includes a gelling agent. The gelling agent causes the gellable component in the simulated liquid blood to form a mass of semi-solid or solid material in response the simulated blood being brought into contact therewith to thereby simulate blood clotting. In certain embodiments, the gellable component is chitosan and/or an alginate compound and the gelling agent is at least one compound which causes the gellable component to desolubulize, polymerize, complex, precipitate, cross-link and the like so as to form a semi-solid or solid mass of chitosan in response to physical contact between the simulated blood and the simulated hemostatic agent.
Coating compositions which include a blend of a fluorochemical and a particulate additive comprising a bimodal size distribution of inorganic nanoparticles are provided. The bimodal distribution of inorganic nanoparticles may include a quantity of smaller nanoparticles having an average size distribution of between about 1 to about 15 nm, and a quantity of larger nanoparticles having an average size distribution of between about 40 to about 500 nm. The smaller and larger nanoparticles may be present in a ratio of the smaller sized particles to the larger sized particles of at least 1.2, with the total amount of nanoparticles being present in an amount of between about 0.1 to about 10 wt. % based on total composition weight.
D06M 15/277 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds of unsaturated carboxylic acidsSalts or esters thereof containing fluorine
D06M 11/36 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with salts derived from anions with an amphoteric element-oxygen bond
D06M 11/78 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with siliconTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with halides or oxyhalides of siliconTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with fluorosilicates
D06M 23/08 - Processes in which the treating agent is applied in powder or granular form
D06B 1/00 - Applying liquids, gases or vapours on to textile materials to effect treatment, e.g. washing, dyeing, bleaching, sizing or impregnating
D06M 11/79 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with silicon dioxide, silicic acids or their salts
D06M 11/53 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof with hydrogen sulfide or its saltsTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with sulfur, selenium, tellurium, polonium or compounds thereof with polysulfides
D06M 11/58 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with nitrogen or compounds thereof, e.g. with nitrides
D06M 11/74 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbon or graphiteTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with graphitic acids or their salts
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Simulated blood for medical purposes; simulated blood concentrate for medical purposes; simulated gauze for medical purposes; clotting solution for medical purposes; kits comprised of simulated blood, simulated gauze, and clotting solution, all for medical purposes Simulated hemorrhage control and wound treatment training device
Coating compositions which include a blend of a fluorochemical and a particulate additive comprising a bimodal size distribution of inorganic nanoparticles are provided. The bimodal distribution of inorganic nanoparticles may include a quantity of smaller nanoparticles having an average size distribution of between about 1 to about 15 nm, and a quantity of larger nanoparticles having an average size distribution of between about 40 to about 500 nm. The smaller and larger nanoparticles may be present in a ratio of the smaller sized particles to the larger sized particles of at least 1.2, with the total amount of nanoparticles being present in an amount of between about 0.1 to about 10 wt.% based on total composition weight.
D06M 11/36 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with oxides, hydroxides or mixed oxidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with oxygen, ozone, ozonides, oxides, hydroxides or percompoundsSalts derived from anions with an amphoteric element-oxygen bond with salts derived from anions with an amphoteric element-oxygen bond
D06M 11/78 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with siliconTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with halides or oxyhalides of siliconTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with silicon or compounds thereof with fluorosilicates
D06M 13/282 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials with non-macromolecular organic compoundsSuch treatment combined with mechanical treatment with compounds containing sulfur or phosphorus with compounds containing phosphorus
D06M 23/08 - Processes in which the treating agent is applied in powder or granular form
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
32.
In-situ sensors and methods for monitoring environment assisted cracking of structural components
Sensor assemblies, units and methods are provided to determine crack development of components of interest associated with a monitored structure. According to preferred embodiments, a sample sensor bolt is provided having a shank with a threaded end, the sensor bolt being formed of a material serving as a surrogate of the material forming a component of interest associated with the monitored structure. A frame surrounds the shank of the sensor bolt and has fluid ports therein to allow fluid to contact an exposed portion of the sensor bolt shank in registry therewith. A load cell is operatively connected to the sensor bolt. A preload nut is threaded onto the threaded end of the sensor bolt shank and contacts an end of the frame so as to place the sensor bolt under an initial tensile stress. Crack formation within the sensor bolt shank caused by fluid acting upon the exposed portion thereof responsively relieves the initial tensile stress of the sensor bolt which is thereby sensed by the load cell, whereby crack formation in the shank can be used to sense the propensity for crack development in the component of interest associated with the monitored structure.
Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.
A61K 31/41 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
C07D 403/00 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group
C07C 67/48 - SeparationPurificationStabilisationUse of additives
34.
Systems and methods to detect particulate debris in a fluid
Methods and systems are provided for detecting presence of a target particulate of predetermined size (e.g., engine wear debris) in a fluid (e.g., an engine lubricant) by providing at least one pair of serially fluid-connected upstream test and downstream reference filtration elements in the fluid. At least the upstream test filtration element has a filtration size rating that is sufficient to remove a predetermined amount of the target particulate from the fluid. The differential pressure of the fluid may then be measured (e.g., by suitable pressure transducers) across each of the test and reference filtration elements. By comparing the differential pressure across the test filtration element to the differential pressure across reference filtration element, the presence of the target particulate in the fluid can thereby be detected by an increase in differential pressure across the test filtration element in comparison to the differential pressure across the reference filtration element. The methods and systems of the invention thus allow for the detection of target particulates that is independent of the fluid flow rate and/or temperature (viscosity, density).
Described herein are methods for treating inflammatorydisorders. The methods comprise administering to a subject in need thereofa therapeutically effective amount of a synthetically modified fullerene.
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
C07C 69/608 - Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
C07C 69/67 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
Endohedral metallofullerene compounds, which in water has a relaxivity of about 30 mM -1 S-1 to about 300 mM-1 S-1 and forms a dispersion in water with entities having an average hydrodynamic radius of less than about 20 nm.
Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
A passive sensor that is located on or adjacent to a structure that can be used to monitor the affect of environment on a structure or coating that is used to protect the structure. The sensor includes a parasitic element that interacts with the environment and influences the intensity of the electromagnetic response between the inductive element of the sensor and the antenna of the interrogation reader device. The condition of the parasitic element is determined by the radio frequency interaction of the reader antenna and the inductive element of the sensor. The parasitic element condition correlates to the environmental severity, or corrosivity of the environment and damage to metallic structures or protective coatings. An integrated circuit within the sensor is capable of storing identification, time, material, and measurement information. The sensor and system of the present invention is useful for tracking and monitoring cumulate environmental damage to a structure.
A pegylated and hydroxlated trimetallic nitride endohedral metallofullerene is provided comprising a plurality of hydroxyl groups and one or more polyethylene glycol (PEG) moieties covalently bonded to a fullerene encapsulating a trimetallic nitride. Methods of pegylation and hydroxylation of trimetallic nitride endohedral metallofullerene and methods of using pegylated and hydroxlated trimetallic nitride endohedral metallofullerene are described.
A material characteristic measurement approach measures an internal state of a material by measuring the nonlinear shift in velocity induced by different acoustic energies. The technology for implementing this measurement approach is relatively simple, robust, permits portable measurements, does not require that an unloaded initial condition of the material be measured or otherwise known in order to determine a characteristic of the material, can be applied using one or more transducers, and does not require physical contact with the material. Some example material characteristics include a residual stress existing without any external mechanical force applied, applied stress, a fatigue state, age, an interference-fit fastener stress, bio-activity, a nanostructure mixture of the material, a heat treatment of the material, a cross-linking of polymers in the material, a bio-growth organization of the material, a clotting factor of blood or blood-like material, a cure of an adhesive or sealant material, or the microstructure of the material.
An exemplary optical limiter device (100) has an optically transmissive substrate (102) and a layer (104) on a first surface (106) of the substrate, the layer having a trimetallic nitride endohedral metallofullerene. The layer can be a thin film of the trimetallic nitride endohedral metallofullerene, a layer material with a cavity containing a solution with the trimetallic nitride endohedral metallofullerene, a sol-gel with a trimetallic nitride endohedral metallofullerene, and a self assembled monolayer with a trimetallic nitride endohedral metallofullerene. The layers of trimetallic nitride endohedral metallofullerenes can be vapor deposited, solution deposited and/or self assembled onto optical components. The third-order nonlinear properties of these films provide desired transmission characteristics.
G02F 1/03 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
C07F 5/00 - Compounds containing elements of Groups 3 or 13 of the Periodic Table
The present invention is directed towards an acoustic concealed item detector and related methods for detection using acoustics. In an illustrative embodiment, a multi-frequency ultrasonic wave generator generates in a gaseous medium at least first and second ultrasonic waves. The multi-frequency ultrasonic wave generator is arranged such that in operation, the first ultrasonic wave and the second ultrasonic wave mix in a prescribed mixing zone to produce a difference-frequency acoustic wave. A receiver sensor detects the difference-frequency acoustic wave and produces corresponding electromagnetic signals. The electromagnetic signals are processed by a system processor and signals indicative of concealed items are identified. Preferably the ultrasonic waves are focused to a small prescribed mixing zone. Parametric and multi-transducer embodiments are disclosed.
