Leica Microsystems Ltd. Shanghai

China

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Date
2025 January 1
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2022 11
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IPC Class
G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome 30
G01N 1/36 - Embedding or analogous mounting of samples 17
G01N 1/28 - Preparing specimens for investigation 7
G01N 1/31 - Apparatus therefor 7
B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member 6
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Found results for  patents

1.

Tissue processor

      
Application Number 29804365
Grant Number D1057990
Status In Force
Filing Date 2021-08-19
First Publication Date 2025-01-14
Grant Date 2025-01-14
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Wang, Yuanyuan
  • Liu, Qiang
  • Li, Lei
  • Zhang, Jingtian

2.

Dryer for histological preparation

      
Application Number 29885342
Grant Number D1056240
Status In Force
Filing Date 2023-02-23
First Publication Date 2024-12-31
Grant Date 2024-12-31
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

3.

Water bath-dryer combination for histological preparation

      
Application Number 29885351
Grant Number D1056241
Status In Force
Filing Date 2023-02-23
First Publication Date 2024-12-31
Grant Date 2024-12-31
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

4.

Automated slide stainer

      
Application Number 29822534
Grant Number D1054053
Status In Force
Filing Date 2022-01-10
First Publication Date 2024-12-10
Grant Date 2024-12-10
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Zhang, Wenwen
  • Sun, Jingguang
  • Zhang, Jingtian

5.

COOLING AND HEATING DEVICE AND EMBEDDER HAVING SAME

      
Application Number CN2023096023
Publication Number 2024/239272
Status In Force
Filing Date 2023-05-24
Publication Date 2024-11-28
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Liang, Yong
  • Wang, Cici
  • Jin, Chris
  • Xie, Jonas

Abstract

A cooling and heating device includes: a carriage including a recess in middle and a peripheral portion surrounding the recess; a cooling section and a heating section arranged on the peripheral portion and encircling the recess together; a motor fixed to the carriage; a driving disk and a driven disk rotatably connected to the carriage and arranged in the recess, the driving disk being connected to the motor; a transmission belt fitted over the driving disk and the driven disk; and a plurality of molds attached to a side surface of the transmission belt facing away from the driving disk and the driven disk and slidably supported on the cooling section or the heating section. The cooling section includes a plurality of cooling stations, which are configured to be covered by at least part of the plurality of molds, respectively, when the transmission belt stops rotating.

IPC Classes  ?

  • H05K 7/20 - Modifications to facilitate cooling, ventilating, or heating
  • B29C 51/24 - Thermoforming apparatus having movable moulds or mould parts mounted on movable endless supports

6.

EMBEDDER AND CONTROL METHOD OF DISPENSING PARAFFIN FOR SAME

      
Application Number CN2023096034
Publication Number 2024/239273
Status In Force
Filing Date 2023-05-24
Publication Date 2024-11-28
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Liang, Yong
  • Liu, Xiaohu
  • Xie, Lingjun
  • Wang, Jinyang

Abstract

An embedder and a control method of dispensing paraffin for the same are provided. The control method includes: moving a press head from an original position towards a mold carried with a cassette until the press head pushes a lid and a bottom of the cassette onto a bottom of the mold; moving the press head away from the mold until a distance sensor detects a first preset distance from the lid of the cassette; dispensing the paraffin into the cassette until the distance sensor detects a second preset distance from the paraffin in the cassette; and stopping dispensing the paraffin and moving the press head away from the mold to the original position.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples

7.

TISSUE CASSETTE AND TISSUE EMBEDDING ASSEMBLY

      
Application Number CN2023091456
Publication Number 2024/221380
Status In Force
Filing Date 2023-04-28
Publication Date 2024-10-31
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Wang, Bingbing
  • Yu, Xufeng
  • Sun, Jinwen
  • Jin, Chun

Abstract

A tissue cassette includes a frame, a cover and a base. The cover is detachably coupled to the frame. The base is detachably coupled to the frame and has an accommodation space configured to contain one or more tissue samples. The cover includes a cover body, a plurality of resilient members and a flexible member. The plurality of resilient members are coupled between the cover body and the flexible member. The flexible member is configured to contact the one or more tissue samples, and the plurality of resilient members are configured to generate a pressure on the one or more tissue samples to retain a position of the one or more tissue samples against the base.

IPC Classes  ?

  • G01N 21/88 - Investigating the presence of flaws, defects or contamination
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

8.

TISSUE CASSETTE

      
Application Number CN2023087755
Publication Number 2024/212121
Status In Force
Filing Date 2023-04-12
Publication Date 2024-10-17
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Sun, Jinwen
  • Yu, Xufeng
  • Wang, Bingbing
  • Jin, Chun

Abstract

A tissue cassette(100), comprising: a frame(110); a cover(130) movably coupled to the frame(110); a base(170) movably coupled to the frame(110); a retaining member(150) coupled to the cover(130) and arranged between the cover(130) and the base(170) in a thickness direction of the tissue cassette(100), the retaining member(150) being configured to retain one or more tissue samples(900) in place between the retaining member(150) and the base(170), wherein the retaining member(150) comprises a plurality of resilient structures spaced apart from each other and arranged crosswise with each other in a first direction perpendicular to the thickness direction of the tissue cassette(100), and the plurality of resilient structures are configured to retain a face of the one or more tissue samples(900) facing the base(170) against the base(170).

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

9.

Water bath for histological preparation

      
Application Number 29885340
Grant Number D1047222
Status In Force
Filing Date 2023-02-23
First Publication Date 2024-10-15
Grant Date 2024-10-15
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

10.

CASSETTE FOR AUTO-EMBEDDER

      
Application Number CN2023086458
Publication Number 2024/207280
Status In Force
Filing Date 2023-04-06
Publication Date 2024-10-10
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Sun, Jinwen
  • Wang, Bingbing
  • Yu, Xufeng
  • Jin, Chun

Abstract

A cassette (100) for an auto-embedder (1000) includes a frame (110), a retaining member (130) and a base (150). The retaining member (130) is coupled to the frame (110). The base (150) is detachably coupled to the frame (110). The base (150) is located outside the frame (110). The retaining member (130) is arranged between the frame (110) and the base (150) and configured to retain a tissue sample in place in the base (150). The base (150) includes a first receiving groove (159) configured to accommodate paraffin during embedding of the tissue sample.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • G01N 1/36 - Embedding or analogous mounting of samples
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

11.

COLLECTING DEVICE FOR LASER PRINTER

      
Application Number CN2023083847
Publication Number 2024/197482
Status In Force
Filing Date 2023-03-24
Publication Date 2024-10-03
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Lu, Lester
  • Wu, Ming
  • Li, Lisa
  • Xie, Alex

Abstract

A collecting device for a laser printer includes an object carrier, an object stage, a pushing member and first and second drive assemblies. The object carrier is movable between first and second positions, in the first position the object carrier is configured to collect an object transferred from the laser printer in a first horizontal direction to form an object stack on the object carrier, and in the second position, the object stack is transferable from the object carrier onto the object stage in a second horizontal direction. The first drive assembly is configured to drive the object carrier to move between the first and second positions. The pushing member is configured to push the object stack from the object carrier onto the object stage in the second horizontal direction. The second drive assembly is configured to drive the pushing member to move in the second horizontal direction.

IPC Classes  ?

12.

AIR PURIFIACTION ASSEMBLY FOR LASER PRINTER

      
Application Number CN2023081277
Publication Number 2024/187366
Status In Force
Filing Date 2023-03-14
Publication Date 2024-09-19
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Lu, Lester
  • Wu, Ming

Abstract

An air purification assembly(100,200) for a laser printer(1000) includes a housing(140,260), a HEPA filter(110,220), an active carbon filter(120,230) and a fan(130,250). The housing(140,260) includes an air inlet(160,2611) and an air outlet(170,2651). The HEPA filter(110,220) is arranged in the housing(140,260). The active carbon filter(120,230) is arranged in the housing(140,260) and downstream of the HEPA filter(110,220). The HEPA filter(110,220) and the active carbon filter(120,230) are arranged downstream of the air inlet(160,2611) and upstream of the air outlet(170,2651). The fan(130,250) is coupled to the housing(140,260) and configured to force air through the HEPA filter(110,220) and the active carbon filter(120,230) to filter the air. A laser printer(1000) having the air purification assembly(100,200) is also provided.

IPC Classes  ?

  • B01D 46/56 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
  • B01D 50/00 - Combinations of methods or devices for separating particles from gases or vapours

13.

LASER PRINTER

      
Application Number CN2023081271
Publication Number 2024/187362
Status In Force
Filing Date 2023-03-14
Publication Date 2024-09-19
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. , SHANGHAI (China)
Inventor
  • Lu, Lester
  • Wu, Ming
  • Li, Lisa
  • Wang, Martin

Abstract

A laser printer includes a printing system and a transportation system. The printing system includes a laser generator configured to laser-print information on an object, and a printing area located below the laser generator in a vertical direction and configured to carry the object. The transportation system includes first and second magazines configured to contain at least one object to be laser-printed, a loading mechanism configured to load the object from the first magazine or the second magazine to the printing area in a first horizontal direction, an unloading mechanism configured to unload the object from the printing area in a second horizontal direction different from the first horizontal direction, and an elevating mechanism configured to selectively raise at least one of the first and second magazines.

IPC Classes  ?

  • B41J 3/407 - Typewriters or selective printing or marking mechanisms characterised by the purpose for which they are constructed for marking on special material
  • B41J 2/435 - Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by selective application of radiation to a printing material or impression-transfer material

14.

GRAPHICAL USER INTERFACE FOR BIOPSY DEVICE

      
Application Number CN2022124601
Publication Number 2024/077477
Status In Force
Filing Date 2022-10-11
Publication Date 2024-04-18
Owner
  • DEVICOR MEDICAL PRODUCTS, INC. (USA)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Xu, Alex
  • Jiang, George
  • Wu, Frank
  • Qu, Lirong
  • Liu, Jason
  • Song, Adair
  • Chen, Christ

Abstract

An apparatus includes a biopsy device, a valve assembly, and a control module. The valve assembly is configured to be in fluid communication with the biopsy device. The control module is configured to be in electrical communication with the biopsy device and in fluid communication with the valve assembly. The control module includes a display. The display is configured to provide instructions for: placing the biopsy device in electrical communication with the control module, inserting the valve assembly into the control module, and placing the valve assembly in fluid communication with the control module.

IPC Classes  ?

  • A61B 10/02 - Instruments for taking cell samples or for biopsy
  • A61B 17/00 - Surgical instruments, devices or methods

15.

TEMPERATURE SENSOR ASSEMBLY FOR WATER BATH AND WATER BATH

      
Application Number CN2022120282
Publication Number 2024/060080
Status In Force
Filing Date 2022-09-21
Publication Date 2024-03-28
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

Abstract

A temperature sensor assembly (100) for a water bath (200) includes a thermal insulation holder (20), a temperature sensor (30), and a thermal conductive member (70). The temperature sensor (30) is coupled to the thermal insulation holder (20). The thermal conductive member (70) is coupled to the thermal insulation holder (20) and in contact with the temperature sensor (30). The thermal conductive member (70) is configured to contact a bottom face of a water tray (210) of the water bath (200). The thermal insulation holder (20) and the thermal conductive member (70) cooperatively define a receiving chamber (95) and the temperature sensor (30) is received in the receiving chamber (95).A water bath (200) is also provided.

IPC Classes  ?

  • B01L 7/02 - Water bathsSand bathsAir baths
  • G01K 1/143 - SupportsFastening devicesArrangements for mounting thermometers in particular locations for measuring surface temperatures
  • G01K 13/12 - Thermometers specially adapted for specific purposes combined with sampling devices for measuring temperatures of samples of material

16.

DEVICE AND METHOD FOR EMBEDDING TISSUE SAMPLE

      
Application Number CN2022092984
Publication Number 2023/220855
Status In Force
Filing Date 2022-05-16
Publication Date 2023-11-23
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Jin, Chun
  • Sun, Jingguang
  • Yu, Xufeng
  • Chen, Jue

Abstract

A device for embedding a tissue sample includes a tissue cassette (10) and a mold (20). The tissue cassette (10) includes a frame (120), a top cover (100) coupled to the frame (120), and a bottom cover (110) coupled to the frame (120). The mold (20) defines a recess (220). The top and bottom covers hold the tissue sample therebetween. The top and bottom covers are capable of moving from a first position to a second position with respect to the frame (120), and in the second position the bottom cover (110) extend beyond a bottom face (123) of the frame (120) and is separated from the frame (120) and the top cover (100); the tissue cassette (10) is mountable on the mold (20), and the recess (220) is configured to receive the bottom cover (110) in the second position, such that a paraffin block (90) obtained by dispensing and cooling molten paraffin in the mold (20) is detachable from the mold (20) while the bottom cover (110) is remained in the mold (20).

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples

17.

DEVICE FOR PRESSING CASSETTE AND EMBEDDER HAVING SAME

      
Application Number CN2022084519
Publication Number 2023/184382
Status In Force
Filing Date 2022-03-31
Publication Date 2023-10-05
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Tao, Hongjian
  • Jin, Chun
  • Lv, Yangming

Abstract

A device for pressing a cassette is provided. The cassette includes an outer frame and an inner frame mounted in the outer frame, and the cassette is configured to be held in a groove of a mold. The device includes a pressing member; an abutment member configured to abut against the cassette; a sensor coupled between the pressing member and the abutment member and configured to measure a pressing force on the cassette, and a guide member configured to be mounted on the mold. The pressing member is detachably mounted to the guide member and slidable on the guide member in a vertical direction. The pressing force on the cassette can be detected in real time by the device according to the present disclosure.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples

18.

EMBEDDING SYSTEM AND EMBEDDING METHOD

      
Application Number CN2022082746
Publication Number 2023/178599
Status In Force
Filing Date 2022-03-24
Publication Date 2023-09-28
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Jin, Chun
  • Chen, Jay
  • Cao, Jingjing
  • Tao, Hongjian

Abstract

An embedding system (100) and an embedding method are provided. The embedding system (100) includes: a cooling container (1) defining a cavity (11) having an opening (111); a cooling liquid (2) contained in the cavity (11) of the cooling container (1); a mold (3) arranged in the cavity (11) and at least partially immersed in the cooling liquid (2), when cooled by the cooling container (1); and an embedding medium (5) arranged in the mold (3) and a sample (6) enclosed in the embedding medium (5), when the mold (3) is cooled by the cooling container (1). The mold (3) is configured to exchange heat with the cooling liquid (2) in such a manner that the embedding medium (5) is cooled and solidified by the cooling liquid (2) to embed the sample (6) in the embedding medium (5).

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

19.

SYSTEM FOR MICROTOMY LABORATORY WITH UNIVERSAL BASE

      
Application Number CN2022077464
Publication Number 2023/159389
Status In Force
Filing Date 2022-02-23
Publication Date 2023-08-31
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

Abstract

A system includes a base, a first accessory component, and a second accessory component. The base includes a receiving body and a control portion. The receiving body includes a receiver and a heating element proximate the receiver. The control portion includes one or more user interface features configured to control the heating element. The first accessory component is configured to process one or more tissue samples after sectioning using a microtome and is further configured for receipt with the receiver. The second accessory component is configured for receipt within the receiver. The first accessory component is configured for a different processing function of one or more tissue samples after sectioning using the microtome relative to the second accessory component. The first accessory component and the second accessory component are configured to be interchangeably received within the receiver.

IPC Classes  ?

  • G01N 1/30 - StainingImpregnating
  • G01N 1/31 - Apparatus therefor
  • B01L 7/00 - Heating or cooling apparatusHeat insulating devices
  • B01L 7/02 - Water bathsSand bathsAir baths
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • B01L 9/00 - Supporting devicesHolding devices

20.

SYSTEM FOR MICROTOMY LABORATORY WITH SINGLE CONTROLLER

      
Application Number CN2022077466
Publication Number 2023/159391
Status In Force
Filing Date 2022-02-23
Publication Date 2023-08-31
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wang, Tao
  • Tian, Xiaoliang

Abstract

A system includes a first base, a second base, a cable, and a control portion. The first base has a first heating element configured to heat a first functional component to increase the temperature of a fluid within the first functional component. The second base has a second heating element configured to heat a second functional component to dry one or more specimen slides. The cable couples the first base to the second base. The control portion is in communication with both the first heating element and the second heating element to control the first heating element and the second heating element simultaneously.

IPC Classes  ?

  • G01N 1/31 - Apparatus therefor
  • B01L 7/00 - Heating or cooling apparatusHeat insulating devices
  • B01L 7/02 - Water bathsSand bathsAir baths
  • F24H 9/20 - Arrangement or mounting of control or safety devices
  • F24H 15/174 - Supplying heated water with desired temperature or desired range of temperature
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • H05K 5/02 - Casings, cabinets or drawers for electric apparatus Details
  • H05K 7/14 - Mounting supporting structure in casing or on frame or rack

21.

COMPOSITE STRUCTURE AND ITS PREPARATION METHOD AND USE

      
Application Number CN2022073613
Publication Number 2023/141739
Status In Force
Filing Date 2022-01-25
Publication Date 2023-08-03
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Lu, Lester
  • Wu, Ming
  • Li, Lisa
  • Yong, Liang

Abstract

A composite structure includes: a substrate, and a printable layer, provide on at least a part of a surface of the substrate and having accommodated therein a colorful material.

IPC Classes  ?

  • B41N 1/14 - Lithographic printing foils
  • B41C 1/10 - Forme preparation for lithographic printingMaster sheets for transferring a lithographic image to the forme
  • B41M 5/24 - Ablative recording, e.g. by burning marksSpark recording

22.

CASSETTE AND EMBEDDING METHOD USING SAME

      
Application Number CN2021129714
Publication Number 2023/082079
Status In Force
Filing Date 2021-11-10
Publication Date 2023-05-19
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Li, Zhongqiu
  • Yu, Xufeng
  • Chen, Jue
  • Xie, Ying

Abstract

A cassette and an embedding method using the same are provided. The cassette includes: a frame including an accommodating member configured to accommodate the tissue, the accommodating member having a first opening and a second opening opposite to each other; a first holder connected to the frame, and configured to rotate relative to the frame to open or close the first opening of the accommodating member; and a second holder connected to the frame, and configured to rotate relative to the frame to open or close the second opening of the accommodating member.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/36 - Embedding or analogous mounting of samples

23.

CASSETTE AND EMBEDDING METHOD USING SAME

      
Application Number CN2021129716
Publication Number 2023/082080
Status In Force
Filing Date 2021-11-10
Publication Date 2023-05-19
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Li, Zhongqiu
  • Chen, Jue
  • Yu, Xufeng
  • Xie, Ying

Abstract

A cassette and an embedding method using the same are provided. The cassette includes: a frame including an accommodating member, the accommodating member defining an accommodating chamber and configured to accommodate the tissue in the accommodating chamber, the accommodating chamber having a first opening and a second opening opposite to each other; a first holder detachably connected to the frame, and closing the first opening of the accommodating chamber; and a second holder connected to the frame, and configured to slide relative to the frame to open or close the second opening of the accommodating chamber.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

24.

Reagent bottle

      
Application Number 29759771
Grant Number D0981590
Status In Force
Filing Date 2020-11-25
First Publication Date 2023-03-21
Grant Date 2023-03-21
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Zhang, Jingtian
  • Tao, Hongjian
  • Wang, Yuanyuan
  • Zhang, Wenwen

25.

Bottle cap

      
Application Number 29759770
Grant Number D0978666
Status In Force
Filing Date 2020-11-25
First Publication Date 2023-02-21
Grant Date 2023-02-21
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Zhang, Jingtian
  • Tao, Hongjian

26.

CASSETTE FOR HOLDING AND ORIENTING TISSUE SAMPLE

      
Application Number CN2021100894
Publication Number 2022/261936
Status In Force
Filing Date 2021-06-18
Publication Date 2022-12-22
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wu, Changhong
  • Li, Zhongqiu
  • Yu, Xufeng
  • Chen, Jue

Abstract

A cassette (1000), including: a frame (100) defining an accommodating chamber (101); an intermediate member (210) coupled to the frame (100) and movably arranged in the accommodating chamber (101), the intermediate member (210) having a through hole (218) in the middle; a cover (220) rotatably connected to the intermediate member (210) and configured to be closed to cover the through hole (218); a base (300) connected to the intermediate member (210) and configured to receive the tissue sample (400); and a retaining member (230) connected to the cover (220) and configured to pass through the through hole (218) to retain the tissue sample (400) in the base (300), the retaining member (230) having a three-dimensional structure made of a two-dimensional porous material.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 1/00 - SamplingPreparing specimens for investigation
  • A01N 1/00 - Preservation of bodies of humans or animals, or parts thereof

27.

CASSETTE FOR HOLDING AND ORIENTING TISSUE SAMPLE

      
Application Number CN2021100898
Publication Number 2022/261939
Status In Force
Filing Date 2021-06-18
Publication Date 2022-12-22
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wu, Changhong
  • Li, Zhongqiu
  • Chen, Jue

Abstract

A cassette (1000) for holding and orienting a tissue sample (2000), includes a frame (100), a retaining assembly (200) and a base (300). The frame (100) defines an accommodating chamber (101). The retaining assembly (200) is movably coupled to the frame (100) and has a biasing member (250). The base (300) is detachably coupled to the retaining assembly (200). The biasing member (250) is configured to urge the tissue sample (2000) towards the base (300) to holding the tissue sample (2000) between the base (300) and the retaining assembly (200). The base (300) is movable along with the retaining assembly (200) relative to the frame (100) between a first position where the base (300) is received in the accommodating chamber (101) and a second position where the base (300) is protruded from the accommodating chamber (101). The cassette (1000) can be used both in tissue processing and embedding, and the orientation of the tissue sample (2000) is not necessary to change.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

28.

CASSETTE AND TISSUE EMBEDDING METHOD USING SAME

      
Application Number CN2021100984
Publication Number 2022/261955
Status In Force
Filing Date 2021-06-18
Publication Date 2022-12-22
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Li, Augustine
  • Wu, Frank
  • Chen, Jay
  • Yu, Edison
  • Chen, Albert
  • Jin, Chris

Abstract

The present disclosure relates to a cassette and a tissue embedding method using the cassette. The cassette includes a frame, a cover and a base. The frame defines an accommodating cavity through a first face and a second face of the frame arranged oppositely in a first direction. The cover is detachably mounted to the frame. The base is detachably mounted to the frame, and the base and the cover are configured to hold and orient a tissue sample therebetween. The base is slidable relative to the frame in a second direction different from the first direction to open and close the accommodating cavity.

IPC Classes  ?

  • B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
  • G01N 1/31 - Apparatus therefor
  • G01N 1/36 - Embedding or analogous mounting of samples

29.

CASSETTE FOR HOLDING AND ORIENTING TISSUE SAMPLE

      
Application Number CN2021100896
Publication Number 2022/261938
Status In Force
Filing Date 2021-06-18
Publication Date 2022-12-22
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wu, Changhong
  • Jin, Chun
  • Chen, Jun

Abstract

A cassette (1000), including: a frame (100) defining an accommodating chamber (101); a retaining assembly (200) coupled to the frame (100) and movably arranged in the accommodating chamber (101); and a base (300) detachably coupled to the retaining assembly (200) and configured to be moved along with the retaining assembly (200), the retaining assembly (200) being configured to retain the tissue sample (400) in the base (300). The retaining assembly (200) and the base (300) are movable between a first position where the base (300) is received in the accommodating chamber (101) and a second position where the base (300) is protruded out of the accommodating chamber (101), and the base (300) is configured to be detached from the retaining assembly (200) when the retaining assembly (200) is in the second position.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 1/28 - Preparing specimens for investigation
  • G01N 1/31 - Apparatus therefor
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • G01N 1/02 - Devices for withdrawing samples
  • G01N 1/00 - SamplingPreparing specimens for investigation

30.

AUTOMATIC METHOD AND DEVICE FOR REAGENT COMPENSATION AND STAINING INSTRUMENT

      
Application Number CN2021099749
Publication Number 2022/257117
Status In Force
Filing Date 2021-06-11
Publication Date 2022-12-15
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD. SHANGHAI (China)
Inventor
  • Sun, Huan
  • Wu, Xuefang
  • Wang, Ting
  • Pu, Xueyan

Abstract

A slide staining apparatus for staining of cells and tissue samples on slides before pathological analysis. The apparatus is operable to stain multiple sets of slides simultaneously and configured with a reagent system having a plurality of reagents. The apparatus includes a slide counter, a controller having a non-transitory memory component with instructions thereon, and a processor configured to determine a count of a set of received slides since the regent system was installed. When the count is below a threshold, the first protocol is used. When the count is above the threshold, slides in-progress are stained, and newly received slides are stained with a second protocol, the first protocol having an eosin reagent step followed by a 95%ethanol reagent step of a first duration, the second protocol having an eosin reagent step followed by a 95%ethanol reagent step of a second duration less than the first duration.

IPC Classes  ?

  • G01N 1/31 - Apparatus therefor
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
  • G01N 1/30 - StainingImpregnating

31.

METHOD AND APPARATUS FOR PROCESSING SAMPLE

      
Application Number CN2021073560
Publication Number 2022/155949
Status In Force
Filing Date 2021-01-25
Publication Date 2022-07-28
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Xie, Lingjun
  • Jiang, Xiaoqi
  • Sun, Gang
  • Wang, Fei

Abstract

This disclosure relates to a method and an apparatus (500) for processing a sample. The method includes acquiring an identification of each cassette in a basket and an identification of each sample contained in the cassette by reading an electronic tag of the cassette (S101,S201), wherein the identification of the cassette and the identification of the sample contained in the cassette are stored in an associated manner in the electronic tag of the cassette; acquiring information of each sample from a library information system based on the identification of the sample (S102,S202); and recording the information of each sample for use in subsequent processing of the sample (S103,S203).

IPC Classes  ?

  • G06K 17/00 - Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups , e.g. automatic card files incorporating conveying and reading operations
  • G06K 19/00 - Record carriers for use with machines and with at least a part designed to carry digital markings

32.

KNIFE HOLDER WITH EMBEDDED BLADE CHANGING APPARATUS

      
Application Number CN2020114464
Publication Number 2022/051978
Status In Force
Filing Date 2020-09-10
Publication Date 2022-03-17
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Chen, Jue
  • Fan, Zheguang
  • Tao, Hongjian

Abstract

Knife holder (100) includes: a base (1); a pressure plate (2) pivotally arranged to the base and configured to releasably clamp a blade in a sectioning position together with the base; and a blade changing apparatus (3) embedded in the base and configured to output an unused blade (4') out of the base to change a used blade(4). The blade changing apparatus is embedded in the base such that the space on both sides of the knife holder will not occupied, thus facilitating a small longitudinal size of the knife holder and also the user's usability of a microtome having the knife holder. Moreover, it is convenient and safe for the user to change the used blade with the embedded blade changing apparatus.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member

33.

MICROTOME

      
Application Number CN2020113228
Publication Number 2022/047698
Status In Force
Filing Date 2020-09-03
Publication Date 2022-03-10
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Tao, Hongjian
  • Jin, Song
  • Zhang, Alice

Abstract

A microtome (1000) includes a blade (100); and a knife holder (200). The blade (100) has a cutting edge (110) configured to section a specimen block (900). The knife holder (200) includes a base (210), a pressure plate (220) and a frame (230). The pressure plate (220) is connected to the base (210), and the pressure plate (220) is adjustable relative to the base (210) to clamp the blade (100) between the base (210) and the pressure plate (220). The frame (230) includes at least one limb (232) and a bridge (234) extending from the at least one limb (232) parallel to the cutting edge (110). The bridge (234) is proximate the cutting edge (110), the bridge (234) and the blade (100) cooperatively define a first gap (300) therebetween, and the bridge (234) and the pressure plate (220) cooperatively define a second gap (400) therebetween.

IPC Classes  ?

  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

34.

XYLENE-FREE TISSUE PROCESSOR AND METHOD FOR PROCESSING TISSUE

      
Application Number CN2020108120
Publication Number 2022/032428
Status In Force
Filing Date 2020-08-10
Publication Date 2022-02-17
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Liu, Bin

Abstract

An improved tissue processor (1) and a method of tissue processing performed by the tissue processor (1). The improved method for tissue processing or the tissue processor (1) is capable of supporting the xylene-free treatment and effectively removing the substitute of xylene (such as isopropanol, IP A), without addition of further protective chemical reagent to remove the isopropanol, thus simplifying the tissue processing method and saving cost significantly.

IPC Classes  ?

35.

TISSUE PROCESSOR

      
Application Number CN2020106114
Publication Number 2022/021288
Status In Force
Filing Date 2020-07-31
Publication Date 2022-02-03
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Liu, Bin
  • Cheng, Qi

Abstract

A tissue processor includes first and second retorts; reagent bottles fluidly coupled with the first and second retorts; infiltrating baths fluidly coupled with first and second retorts; a pressure generating assembly providing positive or negative pressure in at least one of the first and second retorts, to draw or drain reagent or infiltrating material into or from the respective retort; and a rotary valve fluidly coupling first and second retorts with the reagent bottles, and selectively communicating one of the reagent bottles with the first and second retorts. The tissue processor further includes first and second trap bottles, the first trap bottle is fluidly coupled between the first retort and the pressure generating assembly, the second trap bottle is fluidly coupled between the second retort and the pressure generating assembly, the first and second trap bottles condense reagent vapor or infiltrating material vapor from the first and second retorts, respectively.

IPC Classes  ?

36.

METHOD AND APPARATUS FOR MONITORING CONCENTRATION OF REAGENT, ELECTRONIC DEVICE, AND COMPUTER READABLE STORAGE MEDIUM

      
Application Number CN2020106115
Publication Number 2022/021289
Status In Force
Filing Date 2020-07-31
Publication Date 2022-02-03
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Yin, Li

Abstract

A method and an apparatus for monitoring a concentration of a reagent, an electronic device, a computer-readable storage medium. The method includes: acquiring a first concentration of a current reagent measured during filling of the current reagent with a preset concentration; acquiring a current volume of carryover determined in filling and draining a previous reagent; acquiring a second concentration of the current reagent measured during draining of the current reagent and determining, based on the preset concentration, a volume of the reagent bottle and the current volume of carryover, a third concentration of the current reagent; updating the current volume of carryover based on the first concentration, the second concentration and the volume of the reagent bottle (S104); and when the third concentration is less than a preset concentration limit, reminding to replace the current reagent and/or refreshing the current reagent with a higher concentrated reagent.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation

37.

TISSUE PROCESSOR AND METHOD OF PROCESSING TISSUE SAMPLE

      
Application Number CN2020096222
Publication Number 2021/253194
Status In Force
Filing Date 2020-06-15
Publication Date 2021-12-23
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wu, Changhong
  • Pei, Lei
  • Wang, Yuanyuan
  • Jin, Chun

Abstract

A tissue processor and a method of processing a tissue sample by a tissue processor. The tissue processor includes a retort (2) adapted to contain a material to be processed and having an opening, a retort lid (1) configured to open and close the opening of the retort (2), and a heater (3) coupled to the retort lid (1) so as to heat the retort lid (1).

IPC Classes  ?

38.

REAGENT CONTAINER AND TISSUE PROCESSOR

      
Application Number CN2020093177
Publication Number 2021/237653
Status In Force
Filing Date 2020-05-29
Publication Date 2021-12-02
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Zhang, Jingtian
  • Tao, Hongjian
  • Wang, Yuanyuan
  • Wu, Changhong

Abstract

A reagent container (100) for a tissue processor, comprising: a first body (110) defining a cavity (112) configured to contain reagent; and a second body (120) attached to the first body (110), wherein the second body (120) defines a reagent passage (122), a cistern room (124), and a reagent port (126), the reagent passage (122) is in communication with the cavity (112), the cistern room (124) is provided between the reagent passage (122) and the reagent port (126), and in communication with the reagent passage (122) and the reagent port (126), in a flowing direction towards the reagent port (126), the cistern room (124) has a larger section area than the section area of the reagent passage (122). The reagent coming out of the reagent passage (122) will significantly slow down in a short time and will not spill out the reagent container (100) through the reagent port (126), thereby improving anti-spilling performance of the reagent container (100) during transportation or operation.

IPC Classes  ?

  • G01N 1/31 - Apparatus therefor
  • B65D 23/00 - Details of bottles or jars not otherwise provided for

39.

CUTTER HOLDER FOR MICROTOME

      
Application Number CN2021072637
Publication Number 2021/147842
Status In Force
Filing Date 2021-01-19
Publication Date 2021-07-29
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Fan, Zheguang

Abstract

A cutter holder (100) for a microtome includes: a base (10); a pressing plate (20) pivotably mounted to the base and having a first end configured to clamp the cutter (90); an eccentric shaft (30) rotatably mounted in the base; and a sliding assembly (40) slidably mounted in the base. The sliding assembly is arranged between the pressing plate and the eccentric shaft and is in contact with the eccentric shaft, and the sliding assembly is movable towards the pressing plate when the eccentric shaft rotates, so as to force the first end of the pressing plate to clamp the cutter with the base. The cutter holder allows easy mounting and replacement of the pressing plate, facilitates clamping of the cutter and regulation of a clamping force, and has high working efficiency and high reliability.

IPC Classes  ?

  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

40.

TISSUE TREATMENT DEVICE

      
Application Number CN2020131122
Publication Number 2021/104258
Status In Force
Filing Date 2020-11-24
Publication Date 2021-06-03
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Jin, Chun

Abstract

A tissue treatment device, the tissue treatment device comprising: boxes, the boxes being used for carrying tissue; box containers, the boxes being received in the box containers; a workbench, the box containers being movably disposed on the upper side of the workbench; and elastic containers, the elastic containers being disposed on the lower side of the workbench, wherein the workbench defines through holes, the box containers are communicated with the elastic containers by means of the through holes, and each elastic container is configured to extrude a reagent contained therein into the box container when the elastic containers is deformed and to suck the reagent from the box container into the elastic container when the elastic container is restored. When the elastic container is deformed, the reagent contained in the elastic container is extruded into the box container so that the tissue is immersed by the reagent, and when the elastic container is restored, the reagent contained in the box container is sucked into the elastic container to release the tissue from the reagent, so as to achieve the treatment of single tissue by means of a unique solution to prevent cross-contamination.

IPC Classes  ?

  • G01N 1/28 - Preparing specimens for investigation

41.

MOVING AND CLAMPING DEVICE, AND BLADE HOLDER

      
Application Number CN2019117134
Publication Number 2021/092725
Status In Force
Filing Date 2019-11-11
Publication Date 2021-05-20
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Fan, Zheguang

Abstract

The present disclosure provides a moving and clamping device (200) for a blade holder (100) of a microtome. The blade holder (100) includes a blade receptacle (120) configured to receive and clamp a blade. The moving and clamping device (200) includes a rotary member (210) and a clamping member (220). The rotary member (210) is configured to drive the blade receptacle (120) to move in a direction perpendicular to a rotating axis of the rotary member (210), and the clamping member (220) is configured to be movable in the rotating axis of the rotary member (210), so as to operatively clamp or release the blade receptacle (120). The rotary member (210) is rotatably fitted over the clamping member (220). The present disclosure further provides a blade holder (100).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

42.

BLADE LOAD MECHANISM, BLADE UNLOAD MECHANISM AND BLADE CHANGING SYSTEM

      
Application Number CN2019116279
Publication Number 2021/087869
Status In Force
Filing Date 2019-11-07
Publication Date 2021-05-14
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Fan, Zheguang,

Abstract

A blade load mechanism (200) for a blade holder (100) of a microtome. The blade holder (100) has a base (110) defining a blade receptacle (112) configured to receive a blade (900), the blade load mechanism (200) includes a blade supply container (210) configured to contain a blade (900) therein, the blade supply container (210) defining a removal opening (212) through which the blade (900) is able to be removed from the blade supply container (210), and a blade access slot (214) through an outer wall of the blade supply container (210) in a length direction of the blade (900); and a blade pusher (220) configured to engage with the blade (900) through the blade access slot (214) and slide along the blade access slot (214) to push the blade (900) out of the blade supply container (210) through the removal opening (212), and deliver the blade (900) into the blade receptacle (112). A blade changing system (1000) includes a blade load mechanism (200) and a blade unload mechanism (300).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

43.

BLADE HOLDER, BLADE MOVING SYSTEM AND MICROTOME

      
Application Number CN2019114296
Publication Number 2021/081793
Status In Force
Filing Date 2019-10-30
Publication Date 2021-05-06
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Chen, Jue
  • Jin, Song

Abstract

The present disclosure relates to a blade holder (100), a blade moving system (1000) and a microtome (2000). The blade holder (100) includes a base (110) defining a blade groove (112) and a slide groove (114), the blade groove (112) being configured to accommodating a blade (900); a slide rail (120) slidably accommodated in the slide groove (114); and an engagement assembly (130) mounted to the slide rail (120) and configured to engage the blade (900) such that the blade (900) is slidable along the blade groove (112) with sliding of the slide rail (120) in the slide groove (114). By using the blade holder (100) according to embodiments of the present disclosure, the blade (900) can be moved to the left or right along the blade groove (112) by sliding the slide rail (120) in the slide groove (114), thereby facilitating fully use of the blade (900).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member

44.

BLADE ROLLER DEVICE, BLADE EXCHANGE APPARATUS HAVING SAME, AND MICROTOME HAVING SAME

      
Application Number CN2019114297
Publication Number 2021/081794
Status In Force
Filing Date 2019-10-30
Publication Date 2021-05-06
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Zhang, Haixia

Abstract

A blade roller device (100) includes a first blade roll unit (110), a second blade roll unit (120) spaced apart from the first blade roll unit (110), and a first rotate lever (130). The first blade roll unit (110) includes a first slewing mechanism (111) and a first blade roll (112) wound upon the first slewing mechanism (111). The second blade roll unit (120) includes a second slewing mechanism (121) coupled to the first rotate lever (130) and a second blade roll (122) formed by pulling a segment of the first blade roll (112) to the second slewing mechanism (121) and winding the segment of the first blade roll (112) upon the second slewing mechanism (121). A rotation of the first rotate lever (130) in a first direction is capable of pulling the segment of first blade roll (112) to the second slewing mechanism (121).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

45.

BLADE CLAMPING DEVICE FOR MICROTOME

      
Application Number CN2019114572
Publication Number 2021/081861
Status In Force
Filing Date 2019-10-31
Publication Date 2021-05-06
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Jin, Song

Abstract

A blade clamping device (100) for a microtome is provided. The blade clamping device (100) includes: a base part (1); a pressure plate (2) rotatably connected to the base part (1) via a rotation shaft (3); a clamping pin (4) received in the base part (1), and configured to extend out of the base part (1) and push the pressure plate (2) to rotate, so as to clamp a blade (7) between the base part (1) and the pressure plate (2); and a drive unit (5) received in the base part (1), connected to the clamping pin (4) and configured to drive the clamping pin (4) to extend out of the base part (1).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

46.

BLADE MOVING DEVICE, BLADE HOLDING AND CHANGING APPARATUS AND MICROTOME

      
Application Number CN2019114294
Publication Number 2021/081792
Status In Force
Filing Date 2019-10-30
Publication Date 2021-05-06
Owner
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Tao, Hongjian

Abstract

A blade moving device (1) includes: a support base (11); a linear bushing (16) arranged in the support base (11); a moving block (17) received in the support base (11) and movably fitted over the linear bushing (16); a touch connector (18) connected to the moving block (17) and configured to move along with the moving block (17); and a blade box (19) connected to the support base (11) and configured to receive a blade (4) therein. The touch connector (18) is further configured to touch and push the blade (4) to move out of the blade box (19) when moving along with the moving block (17).

IPC Classes  ?

  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

47.

BLADE HOLDER SYSTEM BASED ON RADIO FREQUENCY IDENTIFICATION TECHNOLOGY AND CONTROLLING METHOD THEREOF

      
Application Number CN2019105566
Publication Number 2021/046791
Status In Force
Filing Date 2019-09-12
Publication Date 2021-03-18
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Jin, Song
  • Chen, Jue

Abstract

A blade holder system (100) based on radio frequency identification (RFID) technology and a controlling method thereof. The blade holder system (100) comprises a blade dispenser (10), including a blade (12a,12b) and a radio frequency identification (RFID) tag (111), the RFID tag (111) including ID data relating to the blade dispenser (10); a blade holder (20), including a radio frequency identification (RFID) reading/writing unit (121), configured to establish a wireless communication connection with the RFID tag (111) so as to receive the ID data (130) from the RFID tag (111); and a controller (122), configured to receive the ID data (130) from the RFID reading/writing unit (121), to compare the ID data (130) with preset authorization data (140), and to enable the blade holder (20) to use the blade (12a,12b) in the blade dispenser (10) when the ID data (130) matches with the authorization data (140).

IPC Classes  ?

  • G06K 17/00 - Methods or arrangements for effecting co-operative working between equipments covered by two or more of main groups , e.g. automatic card files incorporating conveying and reading operations

48.

Microtome

      
Application Number 29715315
Grant Number D0903893
Status In Force
Filing Date 2019-12-01
First Publication Date 2020-12-01
Grant Date 2020-12-01
Owner LEICA MICROSYSTEMS LTD. SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Zhang, Jingtian
  • Fan, Zheguang
  • Liang, Xiang

49.

Microtome

      
Application Number 29715317
Grant Number D0903895
Status In Force
Filing Date 2019-12-01
First Publication Date 2020-12-01
Grant Date 2020-12-01
Owner LEICA MICROSYSTEMS LTD. SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Zhang, Jingtian
  • Fan, Zheguang
  • Liang, Xiang

50.

Microtome

      
Application Number 29715316
Grant Number D0903894
Status In Force
Filing Date 2019-12-01
First Publication Date 2020-12-01
Grant Date 2020-12-01
Owner LEICA MICROSYSTEMS LTD. SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Zhang, Jingtian
  • Fan, Zheguang
  • Liang, Xiang

51.

Retraction device and feed mechanism having the same

      
Application Number 16765504
Grant Number 11491677
Status In Force
Filing Date 2018-11-27
First Publication Date 2020-10-08
Grant Date 2022-11-08
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Fan, Zheguang
  • Liang, Xiang
  • Zhou, Gang

Abstract

A retraction device includes: a spindle, a support plate and a plurality of spring washers. The spindle is movable along an axis direction thereof and has a first end; a support plate has a fixed position, the first end of the spindle penetrates the support plate; and the plurality of spring washers are fitted over the first end of the spindle and stacked together in an identical direction. The plurality of spring washers are compressed between the spindle and the support plate with a predetermined pre-load. The spindle is configured to be switchable between a first position and a second position, and capable of moving a predetermined distance relative to the support plate in the axis direction of the spindle during switching. When in the first position, the spindle is farthest from the support plate, when in the second position, the spindle is closest to the support plate.

IPC Classes  ?

  • B26D 7/06 - Arrangements for feeding or delivering work of other than sheet, web, or filamentary form
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

52.

Retraction device and feed mechanism having the same

      
Application Number 16765510
Grant Number 11668628
Status In Force
Filing Date 2018-11-27
First Publication Date 2020-10-01
Grant Date 2023-06-06
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Fan, Zheguang
  • Liang, Xiang
  • Zhou, Gang

Abstract

A retraction device includes a spindle movable along the axis thereof and an operating unit including a pull rod and a movable member. The movable member defines a step-shaped groove, the pull rod has a first end connected to the spindle, and a second end received in the groove; the groove includes a first step and a second step and an inclined face connecting the first step and the second step arranged along a first direction, and a height of the second step is greater than that of the first step along the axis direction of the spindle; the movable member is slidable along the first direction relative to the pull rod, to allow the spindle to switch between a retraction position in which the pull rod is received in the second step, and a release position in which the pull rod is received in the first step.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/06 - Arrangements for feeding or delivering work of other than sheet, web, or filamentary form

53.

Rotating direction change device for microtome

      
Application Number 16650880
Grant Number 11796427
Status In Force
Filing Date 2017-09-29
First Publication Date 2020-07-16
Grant Date 2023-10-24
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor Zhou, Gang

Abstract

A rotating direction change device for a microtome includes: a first shaft arranged in a first fixed position; a first gear wheel non-rotatably mounted to the first shaft; a second shaft movable in a first direction; a second gear wheel non-rotatably mounted to the second shaft; a third shaft movable in a second direction; a third gear wheel non-rotatably mounted to the third shaft; and a first connection part connecting the second shaft and the third shaft such that the second gear wheel is constantly meshed with the third gear wheel, in which the second gear wheel can be driven by the first gear wheel directly or indirectly. Hence, the rotating direction change device has advantages of simple structure and low friction.

IPC Classes  ?

  • F16H 3/40 - Gearings for reversal only
  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • F16H 3/34 - Toothed gearings for conveying rotary motion with variable gear ratio or for reversing rotary motion without gears having orbital motion exclusively or essentially using gears that can be moved out of gear with gears shiftable otherwise than only axially

54.

Rotary microtome and control method for the same

      
Application Number 16626182
Grant Number 11209340
Status In Force
Filing Date 2018-09-26
First Publication Date 2020-07-09
Grant Date 2021-12-28
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Fan, Zheguang

Abstract

A rotary microtome and a control method therefore are provided. The rotary microtome includes: a specimen holder, configured to hold a specimen; a handwheel drive system, including a handwheel and a handwheel axis, and configured to receive a user operation via the handwheel and to move the specimen holder up and down via the handwheel axis based on the user operation; a damping component, connected to the handwheel axis, and configured to generate damping for rotation of the handwheel axis; a knife; a section motor, connected to the knife and configured to drive the knife to cut the specimen; and a control device, connected to the damping component and the section motor respectively, and configured to obtain an operation parameter of the section motor, and to adjust the damping generated by the damping component according to the operation parameter, such that the user feels a material hardness of the specimen.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • G01N 1/28 - Preparing specimens for investigation
  • G05B 19/042 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors

55.

Clamping device and microtome having same

      
Application Number 16609479
Grant Number 11255758
Status In Force
Filing Date 2018-04-11
First Publication Date 2020-06-25
Grant Date 2022-02-22
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Fan, Zheguang
  • Hao, Xiangyu
  • Jiang, Xiaoqi

Abstract

A clamping device includes: an operating member; a wedge having a first inclined surface; a clamping member having a second inclined surface movable relative to the first inclined surface, the first and second inclined surfaces being provided in a face-to-face arrangement; and a housing having a first guiding part, a second guiding part and a chamber. The operating member is mounted in the first guiding part, the clamping member is mounted in the second guiding part, and the wedge is disposed in the chamber; the operating member is operated to move towards the wedge, such that the operating member contacts and pushes the wedge to move, and further the first inclined surface contacts and moves along the second inclined surface; whereby a pushing force of the operating member in a first direction is converted into a clamping force of the clamping member in a second direction.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • G01N 1/28 - Preparing specimens for investigation

56.

Control panel

      
Application Number 29718227
Grant Number D0883235
Status In Force
Filing Date 2019-12-21
First Publication Date 2020-05-05
Grant Date 2020-05-05
Owner LEICA MICROSYSTEMS LTD. SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Fan, Zheguang
  • Zhang, Jingtian
  • Liang, Xiang

57.

Mass-balance means and rotary microtome having same

      
Application Number 16604170
Grant Number 11047770
Status In Force
Filing Date 2018-04-10
First Publication Date 2020-04-16
Grant Date 2021-06-29
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Fan, Zheguang
  • Hao, Xiangyu
  • Jiang, Xiaoqi

Abstract

A mass-balance means and a rotary microtome having the same are provided in the present disclosure. The mass-balance means includes: a connecting element, a first end of the connecting element being configured to be connected with a movable mass of the rotary microtome; a gear set having a preset gear ratio, a first end of the gear set being connected with a second end of the connecting element; an elastic element, the elastic element being pre-tensioned and adjustable, in which a first end of the elastic element is connected with a second end of the gear set for moving along with a rotation of the gear set so as to balance the movable mass.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • G01M 1/36 - Compensating imbalance by adjusting position of masses built-in the body to be tested

58.

Control panel

      
Application Number 29635586
Grant Number D0875052
Status In Force
Filing Date 2018-01-31
First Publication Date 2020-02-11
Grant Date 2020-02-11
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Fan, Zheguang
  • Zhang, Jingtian
  • Liang, Xiang

59.

Microtome

      
Application Number 29635585
Grant Number D0872297
Status In Force
Filing Date 2018-01-31
First Publication Date 2020-01-07
Grant Date 2020-01-07
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Zhou, Gang
  • Zhang, Jingtian
  • Fan, Zheguang
  • Liang, Xiang

60.

CLAMPING APPARATUS FOR SLICING MACHINE

      
Application Number CN2018120216
Publication Number 2019/114680
Status In Force
Filing Date 2018-12-11
Publication Date 2019-06-20
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Zhou, Gang

Abstract

Disclosed is a clamping apparatus for a slicing machine. The clamping apparatus comprises: a base, the base being provided with a non-threaded hole, and a threaded hole which intersects the non-threaded hole; a clamping piece, the clamping piece being movably arranged in the non-threaded hole, a first end of the clamping piece extending out from the non-threaded hole, a second end of the clamping piece being located within the non-threaded hole, a position on the clamping piece near to the second end being provided with a conical hole, the axis of the conical hole being perpendicular to the movement direction of the clamping piece; a first elastic piece, the first elastic piece being arranged within the non-threaded hole, the clamping piece being supported on the first elastic piece; a core shaft, an outer surface of the core shaft being provided with a thread for threaded matching and movement within the threaded hole, a first end of the core shaft being located within the base and having a conical shape so as to be suitable for being inserted into the conical hole, a second end of the core shaft being located outside the base; a driving piece, the driving piece being sleeved on the core shaft and located outside the base; a one-way clutch, the one-way clutch being sleeved on the core shaft and being connected to the driving piece so as to move with the driving piece in a synchronised manner.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/26 - Means for mounting or adjusting the cutting memberMeans for adjusting the stroke of the cutting member
  • B25B 11/00 - Work holders or positioners not covered by groups , e.g. magnetic work holders, vacuum work holders

61.

CONTROLLING A MOTORIZED MICROTOME

      
Application Number CN2017113802
Publication Number 2019/104585
Status In Force
Filing Date 2017-11-30
Publication Date 2019-06-06
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Jiang, Xiaoqi
  • Yang, Yunchao
  • Jin, Song
  • Liang, Xiang
  • Xu, Jinyu

Abstract

A microtome (1) has a cutting knife (4), an object holder (6) mounted on a slide (5), the slide (5) being movable relative to the cutting knife (4) in a cutting direction and in a thickness defining direction, movement of the slide (5) in the thickness defining direction being performed by a first electric motor controlled by a control unit, movement of the slide (5) in the cutting direction being performed by a second electric motor controlled by the control unit, wherein the control unit is configured to control the movement of the slide in the thickness defining direction and in the cutting direction.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

62.

RETRACTION DEVICE AND FEEDING MECHANISM HAVING SAME

      
Application Number CN2018117725
Publication Number 2019/105347
Status In Force
Filing Date 2018-11-27
Publication Date 2019-06-06
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Liang, Xiang
  • Zhou, Gang

Abstract

A retraction device (100) and feeding mechanism (1000), wherein the retraction device (100) comprises a main shaft (10) and an operating unit (20); the main shaft (10) is movable along the axis thereof and is provided with a first end; the operating unit (20) comprises a pull rod (22) and a movable component (24), wherein the pull rod (22) is provided with a first end and a second end, the movable component (24) defines a stepped groove (242), the first end of the pull rod (22) is connected to the first end of the main shaft (10), and the second end of the pull rod (22) is accommodated in the groove (242); the groove (242) comprises first steps (2421) and second steps (2422) arranged in a first direction and an inclined surface (2423) connected to the first steps (2421) and the second steps (2422), and the height of the second steps (2422) along the axial direction of the main shaft (10) is greater than that of the first steps (2421); the movable component (24) is slidable along the first direction relative to the pull rod (22) so as to allow the pull rod (22) to switch between the first steps (2421) and second steps (2422) by means the inclined surface (2423), thus allowing the main shaft (10) to switch between a retraction position and a release position; when the main shaft (10) is in the retraction position, the pull rod (22) is accommodated in the second steps (2422), and when in the release position, the pull rod (22) is accommodated in the first steps (2421).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/06 - Arrangements for feeding or delivering work of other than sheet, web, or filamentary form

63.

RETRACTING APPARATUS AND FEEDING MECHANISM PROVIDED WITH SAME

      
Application Number CN2018117727
Publication Number 2019/105348
Status In Force
Filing Date 2018-11-27
Publication Date 2019-06-06
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Liang, Xiang
  • Zhou, Gang

Abstract

A retracting apparatus (100) comprising: a main shaft (10), a support plate (20), and multiple spring washers (30). The main shaft is movable in the axial direction thereof and is provided with a first extremity. The support plate is in a fixed position and the first extremity of the main shaft runs through the support plate. The multiple spring washers are sleeved on the first extremity of the main shaft and stacked together in a same direction; also, the multiple spring washers are pressed tight by a predetermined preload between the main shaft and the support plate. The main shaft is constructed as switchable between a first position and a second position and movable by a predetermined distance relative to the support plate in the axial direction of the main shaft while switching; at the first position, the main shaft is farthest away from the support part; and, at the second position, the main shaft is closest to the support plate. Also comprised is a feeding mechanism (1000). The retracting apparatus increases the stiffness of the feeding mechanism and improves the quality of slices.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/06 - Arrangements for feeding or delivering work of other than sheet, web, or filamentary form

64.

SLICE COLLECTION TRAY AND SLICER HAVING SAME

      
Application Number CN2018116208
Publication Number 2019/105251
Status In Force
Filing Date 2018-11-19
Publication Date 2019-06-06
Owner
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
  • LEICA BIOSYSTEMS NUSSLOCH GMBH (Germany)
Inventor
  • Dorenkamp Claudia M,
  • Fan, Zheguang
  • Zhou, Gang

Abstract

A slice collection tray (100) and a slicer having same, the slice collection tray (100) comprising a body (10) and an antistatic coating (20), the body (10) having an accommodation groove (11) for accommodating slices, the antistatic coating (20) being provided on at least a portion of the surface of the body (10). The slice collection tray (100) is very easy to clean, not only facilitating the daily cleaning of the slice collection tray (100), but also reducing the time taken by the user to clean the slice collection tray (100), improving the user's work efficiency, and avoiding the use of other tools such as a brush or a scraper, thereby reducing the damage to the surface of the slice collection tray (100); and in addition, the slice collection tray (100) has a low manufacturing cost.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 7/32 - Means for performing other operations combined with cutting for conveying or stacking cut product

65.

ROTARY MICROTOME AND CONTROL METHOD FOR THE SAME

      
Application Number CN2018107564
Publication Number 2019/072086
Status In Force
Filing Date 2018-09-26
Publication Date 2019-04-18
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Fan, Zheguang

Abstract

A rotary microtome (100) and a control method thereof. The rotary microtome (100) includes: a specimen holder (3), configured to hold a specimen; a handwheel drive system, (2) including a handwheel (21) and a handwheel axis (24), and configured to receive a user operation via the handwheel (21), and to move the specimen holder (3) up and down via the handwheel axis (24) based on the user operation; a damping component (5), connected to the handwheel axis (24), and configured to generate damping for rotation of the handwheel axis (24); a knife (4); a section motor (6), connected to the knife (4) and configured to drive the knife (4) to cut the specimen; and a control device (7), connected to the damping component (5) and the section motor (6) respectively, and configured to obtain an operation parameter of the section motor (6), and to adjust the damping generated by the damping component (5) according to the operation parameter, such that the user feels a material hardness of the specimen.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

66.

DEVICE FOR CHANGING ROTATION DIRECTION OF MICROTOME

      
Application Number CN2017104211
Publication Number 2019/061225
Status In Force
Filing Date 2017-09-29
Publication Date 2019-04-04
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Zhou, Gang

Abstract

Disclosed is a device (100) for changing the rotation direction of a microtome, the device comprising: a first shaft (110), the first shaft (110) being arranged at a first fixed position; a first gear (112), the first gear (112) being non-rotatably mounted to the first shaft (110); a second shaft (120), the second shaft (120) being capable of moving in a first direction; a second gear (122), the second gear (122) being non-rotatably mounted to the second shaft (120); a third shaft (130), the third shaft (130) being capable of moving in a second direction; a third gear (132), the third gear (132) being non-rotatably mounted to the third shaft (130); and a first connecting member (140), the first connecting member (140) connecting the second shaft (120) with the third shaft (130) so that the second gear (122) is normally engaged with the third gear (132), wherein the second gear (122) can be directly or indirectly driven by the first gear (112). Thus, the device (100) for changing a rotation direction has the advantages of a simple structure and low friction.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

67.

COARSE FEED DEVICE AND MICROTOME HAVING SAME

      
Application Number CN2018086037
Publication Number 2018/210162
Status In Force
Filing Date 2018-05-08
Publication Date 2018-11-22
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Wang, Chonglu

Abstract

A coarse feed device and a microtome having the same are provided. The coarse feed device includes: a power input unit (10) having an adjustable position; a power output unit (20) disposed in a first fixed position; an idle gear unit (30) disposed between the power input unit (10) and the power output unit (20), and configured to couple the power input unit (10) to the power output unit (20); and a switching unit (40) configured to switch the power input unit (10) between a first position and a second position. The power output unit (20) includes: a first output gear (201) disposed in the first fixed position; and a second output gear (202) fixed to the first output gear (201), and coaxially disposed with the first output gear (202), in which a tooth number of the second output gear (202) is less than a tooth number of the first output gear (201). When the power input unit (10) is located in the first position, the power input unit (10) is coupled to the first output gear (201) via the idle gear unit (30); when the power input unit (10) is located in the second position, the power input unit (10) is coupled to the second output gear (202) via the idle gear unit (30).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

68.

CLAMPING DEVICE AND MICROTOME HAVING SAME

      
Application Number CN2018082592
Publication Number 2018/201865
Status In Force
Filing Date 2018-04-11
Publication Date 2018-11-08
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Hao, Xiangyu
  • Jiang, Xiaoqi

Abstract

A clamping device (10) and a microtome (100) having the same, the clamping device (10) includes an operating member(11); a wedge (12) having a first end (123), a second end (121) and a first inclined surface (122) located between the first end (123) and the second end (121), the wedge (12) being in the form of an expanded shape from the second end (121) to the first end (123); a clamping member (13) having a second inclined surface (1331), the first inclined surface (122) and the second inclined surface (1331) being provided in a face-to-face arrangement and the first inclined surface (122) being movable relative to the second inclined surface (1331); and a housing (14) having a first guiding part (141), a second guiding part (142) and a chamber (144), wherein the operating member (11) is mounted in the first guiding part (141), the clamping member (13) is mounted in the second guiding part (142), and the wedge (12) is disposed in the chamber (144); wherein the operating member (11) is operated to move towards the wedge (12) in a first direction, such that the operating member (11) contacts the first end (123) of the wedge (12) and pushes the wedge (12) to move, and further the first inclined surface (122) of the wedge (12) contacts the second inclined surface (1331) of the clamping member (13) and moves along the second inclined surface (1331); whereby a pushing force of the operating member (11) in the first direction is converted into a clamping force of the clamping member (13) in a second direction.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

69.

MASS-BALANCE MEANS AND ROTARY MICROTOME HAVING SAME

      
Application Number CN2018082478
Publication Number 2018/188581
Status In Force
Filing Date 2018-04-10
Publication Date 2018-10-18
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Fan, Zheguang
  • Hao, Xiangyu
  • Jiang, Xiaoqi

Abstract

A mass-balance means (10, 40) and a rotary microtome (100) having the same. The mass-balance means (10, 40) includes: a connecting element (12), a first end of the connecting element (12) being configured to be connected with a movable mass (11) of the rotary microtome (100); a gear set (20, 30) having a preset gear ratio, a first end of the gear set (20, 30) being connected with a second end of the connecting element (12); an elastic element (14), the elastic element (14) being pre-tensioned and adjustable, in which a first end of the elastic element (14) is connected with a second end of the gear set (20, 30) for moving along with a rotation of the gear set (20, 30) so as to balance the movable mass (11).

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • B26D 5/10 - Hand or foot actuated means

70.

APPARATUS AND METHOD FOR CONTROLLING PARAFFIN DISPENSING IN PARAFFIN DISPENSER AND EMBEDDER

      
Application Number CN2018080845
Publication Number 2018/177322
Status In Force
Filing Date 2018-03-28
Publication Date 2018-10-04
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Wu, Zhiwei
  • Wang, Chonglu
  • Lu, Yu
  • Fan, Zheguang

Abstract

An apparatus (300, 400, 500) and a method for controlling paraffin dispensing in a paraffin dispenser (14, 100), and an embedder (1), wherein the apparatus (300, 400, 500) comprises: an electromagnetic valve (210, 310, 410, 510), mounted on the paraffin dispenser (14, 100); a pedal assembly (320, 420, 520) comprising a foot pedal (321, 421, 521) and a foot switch (322, 422, 522); the foot switch (322, 422, 522) being configured to detect a position where the foot pedal (321, 421, 521) is pressed to and to generate a control signal according to the position; and a controller (330, 430, 530) configured to receive the control signal and to control the magnetic valve (210, 310, 410, 510) to open according to the control signal, so as to control paraffin flow in the paraffin dispenser (14, 100).

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples

71.

Paraffin distribution device for embedder and embedder with the same

      
Application Number 15755069
Grant Number 11047775
Status In Force
Filing Date 2016-08-01
First Publication Date 2018-08-30
Grant Date 2021-06-29
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor Lu, Yu

Abstract

The present invention relates to a paraffin distribution device for an embedder, and an embedder with the same. The paraffin distribution device includes a distribution tube having a first end and a second end; a flow valve disposed on the distribution tube; a paraffin outlet member having a paraffin distribution outlet and connected to the first end of the distribution tube; and a heating strip stuck to the distribution tube, the flow valve and the paraffin outlet member. The present invention can accomplish uniform heating of the distribution tube, the flow valve and the paraffin outlet member, and uniform heat transfer.

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 1/44 - Sample treatment involving radiation, e.g. heat
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • G01N 35/04 - Details of the conveyor system

72.

CONTAINER TO SUPPORT TISSUE SAMPLE TRAY

      
Application Number CN2016101816
Publication Number 2018/068210
Status In Force
Filing Date 2016-10-11
Publication Date 2018-04-19
Owner
  • DEVICOR MEDICAL PRODUCTS, INC. (USA)
  • LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor
  • Keller, Bryan
  • Fleming, Joanne
  • Wang, Chonglou

Abstract

A container (200) contains a tissue sample tray (100) with tissue samples disposed thereon. The container (200) fits in a radiograph machine (300) and thereby allows the tissue samples to be radiographically imaged. The container (200) also defines openings (214, 254, 256) allowing fixation fluid to immerse the tissue samples in the container (200) when the container (200) is immersed in the fixation fluid. The container (200) includes a base (210) and a lid (250). The base (210) includes a floor (227) and sidewalls (226) that cooperate to define a compartment (228), which is configured to receive a tissue sample tray (100). A plurality of bosses (230, 232) extend upwardly from the floor (227) and are configured to maintain positioning of a tissue sample tray (100) received in the compartment (228). The lid (250) is configured to enable placement of a tissue sample tray (100) in the compartment (228) when the lid (250) is open. The lid (250) is configured to enclose a tissue sample tray (100) in the compartment (228) when the lid (250) is closed.

IPC Classes  ?

  • A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
  • A61B 10/02 - Instruments for taking cell samples or for biopsy

73.

Liquid level sensor, method for controlling the same and reactor with the same

      
Application Number 15450540
Grant Number 10151615
Status In Force
Filing Date 2017-03-06
First Publication Date 2017-09-21
Grant Date 2018-12-11
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Wang, Wei
  • Liu, Bin
  • Chen, Peng

Abstract

A liquid level sensor, a method for controlling the same, and a reactor with the same are provided. The liquid level sensor includes a first mounting base and a cable assembly. The cable assembly includes a metal shell disposed on the first mounting base; a heating element for heating the metal shell; and a temperature detector for detecting a temperature of the metal shell.

IPC Classes  ?

  • G01N 1/00 - SamplingPreparing specimens for investigation
  • G01F 23/24 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of resistance of resistors due to contact with conductor fluid
  • B01J 19/24 - Stationary reactors without moving elements inside

74.

Paraffin dispenser, embedder, and control method and control apparatus for paraffin dispenser

      
Application Number 15454221
Grant Number 10139801
Status In Force
Filing Date 2017-03-09
First Publication Date 2017-09-21
Grant Date 2018-11-27
Owner Leica Microsystems Ltd., Shanghai (China)
Inventor
  • Wang, Chonglu
  • Chen, Ningjiang
  • Wu, Zhiwei

Abstract

A control method and a control apparatus for a paraffin dispenser in an embedder, a paraffin dispenser and an embedder are provided. The control method includes: collecting information of a current mold so as to acquire an identification of the current mold; determining whether the identification of the current mold is correct; and controlling the paraffin dispenser to pour paraffin into the current mold, when it is determined that the identification of the current mold is correct.

IPC Classes  ?

  • G05B 19/12 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers using record carriers
  • B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor
  • B29C 39/24 - Feeding the material into the mould
  • B29C 39/44 - Measuring, controlling or regulating
  • G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
  • G01N 1/36 - Embedding or analogous mounting of samples
  • G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
  • B29K 91/00 - Use of waxes as moulding material
  • G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor

75.

PARAFFIN WAX DISPENSING APPARATUS USED IN EMBEDDING MACHINE AND EMBEDDING MACHINE HAVING SAME

      
Application Number CN2016092754
Publication Number 2017/032208
Status In Force
Filing Date 2016-08-01
Publication Date 2017-03-02
Owner LEICA MICROSYSTEMS LTD., SHANGHAI (China)
Inventor Lu, Yu

Abstract

Disclosed are a paraffin wax dispensing apparatus (100) used in an embedding machine and the embedding machine having same. The paraffin wax dispensing apparatus (100) comprises: a distributing pipe (110), wherein the distributing pipe (110) has a first end (111) and a second end (112); a flow valve (120), wherein the flow valve (120) is arranged on the distributing pipe (110); a paraffin wax outlet piece (130), wherein the paraffin outlet piece (130) has a paraffin wax distributing outlet (131) and is connected to the first end (111) of the distributing pipe (110); and a heating zone (140), wherein the heating zone (140) is attached to the distributing pipe (110), the flow valve (120) and the paraffin wax outlet piece (130). The present invention can achieve uniform heating and uniform heat transfer for the distributing pipe (110), the flow valve (120) and the paraffin wax outlet piece (130).

IPC Classes  ?

  • G01N 1/36 - Embedding or analogous mounting of samples

76.

Embedder having mobile dispenser

      
Application Number 14953317
Grant Number 09523630
Status In Force
Filing Date 2015-11-28
First Publication Date 2016-06-30
Grant Date 2016-12-20
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Chen, Ningjiang
  • Chu, Yuan
  • Wang, Chonglu

Abstract

An embedder for embedding specimens in paraffin wax includes: a body having a paraffin reservoir for containing the paraffin wax; and a mobile dispenser disposed on the body, capable of being taken off from the body, and defining an inlet and an outlet, the inlet being communicated with the paraffin reservoir via a connecting tube so as to supply the paraffin wax in the paraffin reservoir to the mobile dispenser via the connecting tube, the mobile dispenser dispensing the paraffin wax via the outlet. With the embedder according to embodiments of the present invention, by means of the mobile dispenser detachably connected with the body, the embedder is flexible to use, convenient to operate, and high in efficiency.

IPC Classes  ?

  • A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
  • G01N 1/36 - Embedding or analogous mounting of samples
  • B01L 3/02 - BurettesPipettes

77.

Embedder

      
Application Number 14953318
Grant Number 09518902
Status In Force
Filing Date 2015-11-28
First Publication Date 2016-06-30
Grant Date 2016-12-13
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Chen, Ningjiang
  • Chu, Yuan
  • Wang, Chonglu

Abstract

An embedder is provided. The embedder includes a body having a working stand; a paraffin reservoir disposed in the body; a paraffin dispenser disposed on the body and connected with the paraffin reservoir; a heated working plate disposed on the working stand; a cooling plate disposed on the working stand; a tray disposed on the working stand; and a ceramic layer at least formed on an inner wall surface of the tray. With the embedder according to the present invention, by coating the ceramic layer on the inner wall surface of the tray to form an anti-scratch protective layer, when removing solidified paraffin wax on the inner wall surface of the tray, it is possible to avoid scratching the inner wall surface of the tray so as to avoid the damage to the surface of the tray.

IPC Classes  ?

  • A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
  • G01N 1/36 - Embedding or analogous mounting of samples

78.

Adjusting device for an illumination component of a microscope, a microscope illumination device and a microscope

      
Application Number 14706373
Grant Number 10108000
Status In Force
Filing Date 2015-05-07
First Publication Date 2015-11-19
Grant Date 2018-10-23
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Qian, Chris
  • Dong, Gloria

Abstract

An adjusting device for an illumination component of a microscope, an illumination device and a microscope containing the adjusting device are disclosed. The adjusting device for an illumination component of a microscope includes a first barrel component having an axis; a second barrel component received in the first barrel component, the second barrel component having an axis coincident with or parallel to the axis of the first barrel component, wherein the second barrel component houses and supports the illumination component; and a plurality of set screws each having a first end coupled to a side wall of the first barrel component at a corresponding coupling point and a second end pressed against a side wall of the second barrel component. With embodiments of the present invention, the structure is simpler and the cost is lower.

IPC Classes  ?

79.

Mass-balancing arrangement and microtome using same

      
Application Number 14287003
Grant Number 10107719
Status In Force
Filing Date 2014-05-24
First Publication Date 2015-02-19
Grant Date 2018-10-23
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Fan, Zheguang
  • Zhou, Xiao

Abstract

A mass-balancing arrangement comprises an adjustably pre-loaded spring member (14); a pivotably mounted lever (16; 31) for compensating different inertial forces in combination with the spring member (14); a first drawing member (24) connecting a movable mass to the lever (16); a second drawing member (17) connecting the spring member (14) to the lever (16); and a first roller (15) for deflecting the first drawing member (24). The lever (16; 31) has an upper lever arm (19; 32) and a lower lever arm (20; 33), one being sector-shaped and the other cam-shaped. The upper lever arm is connected to the movable mass through the first drawing member (24), and the lower lever arm is connected to the spring (14) through the second drawing member (24). Two torques produced at the upper and lower lever arms are kept balanced. The balanced mass may be an object carriage of a microtome.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • F16F 15/22 - Compensation of inertia forces
  • F16F 15/26 - Compensation of inertia forces of crankshaft systems using solid masses, other than the ordinary pistons, moving with the system

80.

Microtome having means for reversing a direction of rotation

      
Application Number 14287002
Grant Number 10073011
Status In Force
Filing Date 2014-05-24
First Publication Date 2015-02-19
Grant Date 2018-09-11
Owner Leica Microsystems Ltd. Shanghai (China)
Inventor
  • Fan, Zheguang
  • Zhou, Xiao

Abstract

A microtome has first and second shafts at different fixed positions, wherein the first shaft may be rotated by a hand wheel. The shafts carry first and second gear wheels, respectively. A transmission unit couples the two gear wheels to each other so that the second shaft can be driven to rotate by the first shaft, and a shift unit for pivotably shifting the transmission unit between first and second positions. The two shafts rotate in the same direction when the transmission unit is in the first position, and in opposite directions when the transmission unit is in the second position. The transmission unit includes first and second idler gears meshing constantly with each other. The two shafts are coupled by only one of the idler gears when the transmission unit is in the first position, and by both idler gears when the transmission unit is in the second position.

IPC Classes  ?

  • G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
  • F16H 3/40 - Gearings for reversal only
  • F16H 1/20 - Toothed gearings for conveying rotary motion without gears having orbital motion involving more than two intermeshing members
  • F16H 3/34 - Toothed gearings for conveying rotary motion with variable gear ratio or for reversing rotary motion without gears having orbital motion exclusively or essentially using gears that can be moved out of gear with gears shiftable otherwise than only axially