Abstract

A first aspect of this disclosure relates to a method for operating a microtome (100, 200) for a cutting process, the microtome (100, 200) having a knife (112) with a cutting edge (114) and having a sample (122) on a sample holder (120); said method comprising the following steps: - determining a light gap (300) which is defined in some sections by the cutting edge (114) and the sample (122), and - orienting the knife (112) and/or the sample (122) such that the light gap (300) has a predefined structure.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

Abstract

A method for producing a section ribbon from a sample block includes producing a first part ribbon of the section ribbon from a first surface region of the sample block using a microtome comprising a blade. The first part ribbon has one or more first sections of the sample block. The method further includes producing a second part ribbon of the section ribbon from a second surface region of the sample block using the microtome comprising the blade. The second part ribbon has one or more second sections of the sample block. The second surface region is different from the first surface region. The method further includes retracting the sample block from the blade between the producing of the first part ribbon and the producing of the second part ribbon.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
• G01N 1/36 - Embedding or analogous mounting of samples

Abstract

Provided is a method for characterizing a scanning mirror in a scan control system to determine control parameters for use in a closed-loop feedback configuration of the scan control system. The system (100) comprising: a scanning mirror arrangement (102) comprising the scanning mirror (104); a position sensing detector (106) having a two- dimensional detection surface (108); a light source (110) configured to emit a light beam (112) onto the scanning mirror (104) such that the light beam (112) is deflected onto the position sensing detector (106), wherein the position sensing detector (106) is configured to output a measured position (114) based on the position at which the light beam (112) impinges on the two-dimensional detection surface (108) of the position sensing detector (106), the measured position (114) pertaining to a tilt angle (116) of the scanning mirror (104); a scan mirror controller (118) configured to drive, using drive parameters (120), the scanning mirror arrangement (102) such that the scanning mirror (104) is tilted in angle in two-dimensions; and a processor (122) communicatively connected to the scan mirror controller (118), wherein the scan mirror controller (118) is configured to receive a set of control parameters (126) for use in a closed-loop feedback configuration of the scan control system.

IPC Classes  ?

• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01B 9/02 - Interferometers
• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G02B 26/10 - Scanning systems

Abstract

A system for imaging a sample is disclosed. The system comprises a light source, a movable mirror, a photodetector, a first control unit and a second control unit. The light source generating a light beam and directing the light beam to the movable mirror which then deflects the light beam onto the sample. The photodetector detects light reflected from the sample. The first control unit steers the movable mirror according to position coordinates. The second control unit generates a data packet comprising the position coordinates and sending the data packet to the first control unit. The second control unit also generates trigger signals for the photodetector, the trigger signals being configured to trigger the photodetector to capture images corresponding to each of the position coordinates of the movable mirror. The first control unit and the second control unit communicate over Ethernet such that synchronization between the steering of the movable mirror and the triggering of the photodetector is enabled.

IPC Classes  ?

• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions

Abstract

Provided is a method for characterizing a scanning mirror in a scan control system to determine feedback parameters for a scanning mirror to be used in a closed-loop feedback configuration of the scan control system. The system (100) comprising: a scanning mirror arrangement (102) comprising the scanning mirror (104); a position sensing detector (106) having a two-dimensional detection surface (108); a light source (110) configured to emit a light beam (112) onto the scanning mirror (104) such that the light beam (112) is deflected onto the position sensing detector (106), wherein the position sensing detector (106) is configured to output a measured position (114) based on the position at which the light beam (112) impinges on the two-dimensional detection surface (108) of the position sensing detector (106), the measured position (114) pertaining to a tilt angle (116) of the scanning mirror (104); a scan mirror controller (118) configured to drive, using drive parameters (120), the scanning mirror arrangement (102) such that the scanning mirror (104) is tilted in angle in two-dimensions; a processor (122) communicatively connected to the scan mirror controller (118) and a memory (123); wherein in the memory (123) comprises at least one of position deviation values (130) and a set of compensated positions (136) for use as feedback parameters for close-loop position feedback (138) in the closed-loop feedback configuration of the scan control system (100), the set of compensated positions (136) pertaining to a determined (208) a set of position deviation values (130) obtained for a set of measured positions (128) relative to a set of reference positions (132).

IPC Classes  ?

• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01B 9/02 - Interferometers
• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G02B 26/10 - Scanning systems
• G01B 21/04 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring length, width, or thickness by measuring coordinates of points
• G02B 26/12 - Scanning systems using multifaceted mirrors

Abstract

A highly dispersive single-mode optical fibre comprising drawn bulk optical glass. The optical fibre may be configured as an optical fibre in a reference arm of an interferometer in some embodiments. This may assist with the depth to which B and volumetric scans can be resolved to in live OCT scan streaming, for example by allowing faster techniques to be used for complex conjugate resolution of the scan images. The highly dispersive single-mode optical fibre may be used in a reference paths (103) or scanning path (105) of an OCT system (100).

IPC Classes  ?

• G01B 9/02 - Interferometers
• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G01B 9/02056 - Passive reduction of errors
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G02B 6/02 - Optical fibres with cladding
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light

Abstract

A scanning mirror system (310, 1100) comprising a MEMS scanning mirror assembly (310), the scanning mirror assembly comprising a reflective surface (334), wherein the scanning mirror assembly is configured to reflect a primary light beam in a first optical plane, the reflected primary light beam (312) forming a scanning beam (312), reflect a secondary light beam (400) in a second optical plane, the reflected secondary light beam forming a mirror position reference beam (402); and a position sensitive detector (160), wherein after reflection by the reflective surface (334), the mirror position reference beam (402) is incident on the PSD (160), and the PSD (160) is configured to detect the position of incidence of the mirror position reference beam (402), and wherein any stray light returned from the PSD (160) towards the reflective surface (334) is reflected by the reflective surface (334) in a third optical plane different from the first and second optical planes.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G02B 21/00 - Microscopes
• G02B 26/10 - Scanning systems
• A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light

Abstract

A scanning mirror system (1100) comprises a MEMS scanning mirror assembly (310), the MEMS scanning mirror assembly comprising a reflective surface (334) configured to reflect light from two different light sources. One light source (308a) is a source for a primary beam (312) which after reflection by the reflective surface forms a probe beam. The other light source (158, 502) being a light source for a secondary light beam (400) which, after reflection by the reflective surface (334) forms a mirror position reference beam (402). The system (1100) also comprises a position sensitive detector, PSD (160) configured to detect incident light of the mirror position reference beam (402), wherein the PDS (160) is configured to generate an feedback signal (1704) indicative of where the mirror position reference beam (402) is incident on the position sensitive detector (160) and send the feedback signal (1704) to a controller (1700). The controller is configured to be responsive to a beam direction input signal and the feedback signal, and generate a drive signal. The scanning mirror system also comprises a mirror mover mechanism (1708) configured to be controlled by the drive signal (1706) from the controller (1700), to adjust the position of the MEMS mirror reflective surface (334) to control the direction of the probe beam.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
• G02B 26/10 - Scanning systems

Abstract

An optical coherence tomography, OCT, adapter (206) configured to be under- mounted to a microscope (200), the OCT adapter (206) comprising: a housing (208) configured with a mounting mechanism for engaging with an under-carriage of the microscope (200) and a plurality of optical components (210, 310, 330, 316, 318) contained in the housing (200), wherein at least the plurality of optical components defining an optical path for a OCT probe beam (312) which emerges from the housing collinear with an optical channel of the microscope, wherein the optical components are configured such that the housing (208) of the OCT adapter (206), when fixed to an undercarriage of the microscope (200), increases a height, h2, of the microscope by less than 40mm.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G02B 21/00 - Microscopes
• G02B 26/10 - Scanning systems
• A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A micro-electro-mechanical system, MEMS, two-dimensional scanning mirror assembly (310), the scanning mirror assembly having an optical design comprising a moveable MEMS scanning mirror having a reflective surface (334), a point light source (308a) for a light beam, a collimating lens assembly (516) configured to receive light from the light source and output a collimated light beam with an exit beam diameter above a threshold towards the reflective surface (334), and an objective lens assembly (510, 512) via which a collimated light beam reflected from the reflective surface exists the scanning mirror assembly. The reflective surface (334) is configured to reflect an incident collimated light beam to form a probe beam (312) which exits the mirror assembly as a telecentric beam (312) towards a telecentric image plane with a resolution better than a threshold for the telecentric beam resolution. The optics of the scanning mirror assembly are configured to provide a total track length, L, from the point light source to the telecentric image plane (700) less than 40mm.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G02B 21/00 - Microscopes
• G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
• G02B 26/10 - Scanning systems
• G02B 21/22 - Stereoscopic arrangements

Abstract

A computer-implemented image processing method for removing complex conjugate image data from image data in real-time using dispersion comprising receiving an image signal comprising image data including complex conjugate image data (902), performing baseline signal subtraction (906), resampling wavelength data to generate linear wavenumber image data (908, 910), processing the linear wavenumber image data to generate a complex conjugate resolved, CCR, result using at least one iteration of a CCR image processing algorithm (912), and computing a CCR image from the CCR result (914); and separating the resulting CCR image from the received OCT image data to remove the complex conjugate image data. The method may be performed in real-time and may use phase or magnitude data or a synthesis of the two when generating the image data from the CCR result.

IPC Classes  ?

• G01B 9/02 - Interferometers
• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01B 9/02056 - Passive reduction of errors
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light
• G01N 21/47 - Scattering, i.e. diffuse reflection

Abstract

A highly dispersive single-mode hybrid optical fibre (1900) located in one of a reference arm or a probe arm of an optical interferometer, the hybrid fibre (1900) comprising at least two optical fibres (1902, 1902), at least one of the at least two optical fibres having a different core diameter and different dispersive characteristics to at least one other optical fibre of the at least two optical fibres, wherein the at least two optical fibres are end-to-end fused to form a hybrid optical fibre, and wherein each one of the at least two optical fibres has a length based on the core diameter of that optical fibre relative to a central wavelength of a light beam passing through the hybrid optical fibre and a target GDD per unit length based on the target length of the hybrid optical fibre, wherein the hybrid optical fibre adds an additional GDD value compared to an optical fibre in the other one of the reference arm or probe arm of the optical interferometer.

IPC Classes  ?

• G01B 9/02 - Interferometers
• G02B 6/02 - Optical fibres with cladding
• H04B 10/2525 - Arrangements specific to fibre transmission for the reduction or elimination of distortion or dispersion due to chromatic dispersion using dispersion-compensating fibres
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06T 7/521 - Depth or shape recovery from laser ranging, e.g. using interferometryDepth or shape recovery from the projection of structured light
• G01B 9/02056 - Passive reduction of errors
• G01B 9/02055 - Reduction or prevention of errorsTestingCalibration
• G01B 9/02091 - Tomographic interferometers, e.g. based on optical coherence
• G01N 21/47 - Scattering, i.e. diffuse reflection

Abstract

The invention relates to a cutting movement arrangement (200) for a microtome, wherein the cutting movement arrangement (200) has one or the other out of a blade holder or sample holder (202), wherein the cutting movement arrangement (200) has an adjusting mechanism (210) by means of which the one or other out of the blade holder or sample holder (202) can be moved in a restoring movement (R), and wherein the cutting movement arrangement (200) has an additional adjusting device (220), different from the adjusting mechanism (210), and wherein the cutting movement arrangement (200) is designed such that by means of the additional adjusting device (220) the adjusting mechanism (210) can be prompted to at least partially carry out the restoring movement (R). The invention also relates to a microtome and to a method therefor.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

Abstract

A controller for a microtome configured to cut slices from a sample block is configured to control a display to visualize a virtual representation of the sample block, receive first user input data indicative of a front surface of the sample block, determine a virtual front surface of the sample block based on the first user input data, receive second user input data indicative of an edge of the front surface of the sample block, determine a virtual edge of the front surface of the sample block based on the second user input data, receive third user input data indicative of a cutting plane intersecting the sample block, determine a virtual cutting plane intersecting the sample block based on the third user input, and determine alignment parameters based on the virtual front surface and the virtual edge of the front surface of the sample block and the virtual cutting plane.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

Abstract

A sample holder for holding a sample carrier for carrying a microscopic sample is provided. The sample holder includes a clamping arrangement with an upper leg and a lower leg. The clamping arrangement is configured to clamp the sample carrier between the upper leg and the lower leg, such that a part of the sample carrier is clamped between respective first ends of the upper leg and the lower leg. The clamping arrangement is also configured to be actuated by an external force such that the respective first ends of the upper and lower leg are separated from each other. The clamping arrangement is also configured to exert a clamping force via the respective first ends of the upper and lower leg to the sample carrier to clamp the sample carrier between the upper and lower leg, when the clamping arrangement is not actuated by the external force.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

The invention relates to a sample holder (100) for holding a sample carrier (150), wherein the sample holder comprises a reception area configured to receive the sample carrier (150), wherein the sample holder comprises two legs, wherein the two legs are connected to each other and wherein each leg has a free end, and wherein the sample holder is configured to exert a clamping force (Fa, Fb, Fc, Fd) via the two legs to the sample carrier, in order to clamp the sample carrier between the two legs, when the sample carrier is received in the reception area. The invention relates to a handling tool and to corresponding methods.

IPC Classes  ?

• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

A sample holder includes a main component comprising a first surface area, and a retaining mechanism comprising a holding component. The retaining mechanism is configured to retain a sample between the holding component of the retaining mechanism and the first surface area in a closed state of the retaining mechanism. The retaining mechanism is further configured to enter an opened state upon mechanical actuation of the retaining mechanism. The opened state allows insertion and removal of the sample. The retaining mechanism is further configured to revert to the closed state once the mechanical actuation is removed.

IPC Classes  ?

• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Goods & Services

Surgical imaging devices; surgical microscopic imaging systems; ophthalmological apparatus and instruments, head- mounted display devices for surgery or for surgical microscopy

Goods & Services

Surgical imaging devices; surgical microscopic imaging systems; ophthalmological apparatus and instruments, namely, ophthalmic cameras for medical purposes; head-mounted video displays for surgery and for surgical microscopy

Abstract

A microtome system for cutting sections from a specimen includes a knife including a knife edge configured to cut a section from the specimen, a knife holder, a specimen holder, an illumination, a first actor, a detector, and a controller. The knife holder and specimen holder are configured to be relatively moveable in a cutting direction. The first actor is configured to cause a rotation of the knife holder or specimen holder about an axis. The illumination is configured to illuminate a gap between a front face of the specimen and the knife edge to generate a light gap. The detector is configured to detect a geometric feature of the light gap. The controller is configured to automatically align, or provide indications to manually align, the knife edge with the front face, by controlling the first actor depending on the detected geometric feature.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
• G01N 1/28 - Preparing specimens for investigation

Abstract

A method is proposed for generating a series of ultra-thin sections of a microscopic sample (10), wherein the sections (11) are detached from the sample (10) using an ultramicrotome (100) and wherein the sections (11), which are detached from the sample (10) are caused to float on a liquid surface and are thereafter transferred onto a solid carrier element (20). For at least for some of the sections (11) detached from the sample (10) a position and an orientation on the solid carrier element (20) are determined by monitoring the placement of these sections (11) onto the solid carrier element (20) using a monitoring system (400) comprising a camera (410), obtaining monitoring data. A method (2000) for the three-dimensional reconstruction of a microscopic sample (10), a microtome system and a computer program are also part of the present invention.

IPC Classes  ?

• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
• G01N 1/28 - Preparing specimens for investigation
• G06T 7/00 - Image analysis
• G06T 7/70 - Determining position or orientation of objects or cameras

Goods & Services

Scientific apparatus and instruments; microscopes; microscopes for medical use; microscope parts and components; surgical microscopes; surgical microscope parts and components; microscopes for operations; surgical microscopes for eye surgery; medical devices and instruments; microscopes and microscopes for operations; microscopes for operations, for surgical use; microscopes for operations, for eye surgery; microscopes and surgical microscopes with integrated OCT (optical coherence tomography) functions; optical systems for microscopes; parts and accessories for all the aforesaid apparatus and instruments; microscopic imaging systems; accessories for microscopes; apparatus and systems for 3D microscopy and associated software; cameras, head-up displays and monitors for use in microscopes and surgical microscopes; display units; head-mounted display devices; stereoscopic 3D screens for head mounting; computer software for use with microscopes; computer software for capturing and processing data and images for use with microscopes and microscopes for operations; computer software for microscopes and microscopes for operations; accessories for surgical microscopes. Surgical imaging devices; surgical microscopic imaging systems; ophthalmological apparatus and instruments. Design and development of computer hardware and software for microscopes and surgical microscopes; scientific and technological services as well as design and development of computer hardware and software. Advisory and information services with respect to medical products; medical services; medical equipment rental; provision of medical facilities.

Abstract

A sample holder transfer device is for use in cryo-microscopy and for transferring a sample holder to an analysing or processing unit. The sample holder is configured for holding a sample carrier carrying a sample. The sample holder transfer device is configured to receive the sample holder, the sample holder including a sample carrier fixing element. At least one section of the sample carrier fixing element is configured, when in a first position, to fix the sample carrier to the sample holder, and, when in a second position, to release the sample carrier or provide access to an area where the sample carrier is to be placed. The sample holder transfer device includes a switching mechanism operable to switch the at least one section of the sample carrier fixing element of the sample holder from the first to the second position or from the second to the first position.

IPC Classes  ?

• G02B 21/24 - Base structure
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

A sample holder for holding a sample carrier carrying a sample includes a sample carrier fixing element. The sample carrier fixing element includes a first section configured, when in a first position, to fix the sample carrier to the sample holder, and, when in a second position, to release the sample carrier or to provide access to an area where the sample carrier is to be located. The sample carrier fixing element also includes a second section different from the first section, the second section being operable such that upon operation of the second section the first section switches from the first position into the second position or from the second position into the first position.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

A system for controlling a filling level of a reservoir filled with a liquid includes the reservoir configured to be filled with the liquid at least up to a maximum filling level. The system also includes a probe including a probe body, at least a section of the probe body extending, in a height dimension of the reservoir, from a first position to a second position, the first position being lower than the second position, and the second position being above the maximum filling level, and further including a temperature dependent sensor configured to generate a sensor signal based on a temperature at the second position, the temperature depending on the filling level. The system also includes a controller for controlling the filling level of the reservoir depending on the sensor signal such that the filling level is kept constant.

IPC Classes  ?

• B01L 7/00 - Heating or cooling apparatusHeat insulating devices
• G05D 9/12 - Level control, e.g. controlling quantity of material stored in vessel characterised by the use of electric means
• G02B 21/26 - StagesAdjusting means therefor
• G05B 19/4155 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by programme execution, i.e. part programme or machine function execution, e.g. selection of a programme

Goods & Services

Laboratory instruments for the detection of pathogens and toxins in biological specimens for research purposes; microtomes; ultramicrotomes; separating apparatus for laboratory use; sample chambers for laboratory use (other than for medical purposes) for the safe transport of [cell] samples; sample chambers for laboratory use (other than for medical purposes) for the transport of [cell] samples from the laboratory to the microscope; sample chambers for laboratory use (other than for medical purposes) for the transport of [cell] samples from the laboratory to the examination apparatus; sample chambers for laboratory use (other than for medical purposes) for the transport of samples between examination apparatus and freezers; sample chambers for laboratory use (other than for medical purposes) for transporting samples between microscopes and high-pressure freezers; sample chambers for laboratory use (other than for medical purposes) for observing samples; scientific instruments and apparatus for fixing [cell] samples; scientific apparatus for fixing microscopic samples; freezers (scientific apparatus) for fixing cell samples; freezers (scientific apparatus) for fixing microscopic specimens; high-pressure freezers (scientific apparatus) for fixing microscopic specimens; artificial intelligence software; machine learning software; virtual assistant software; artificial intelligence software and machine learning software; biometric software; production support software; sensory software; adaptive software; assistive software; engineering software; three-dimensional image manipulators [software]. Disposable microtome blades; medical apparatus and instruments for fixing cell samples; scientific, pathological and clinical laboratory apparatus and equipment for use in connection with medical analysis, diagnosis and research; scientific and diagnostic laboratory apparatus and accessories for collecting, preparing, cutting, sectioning, holding and placing histological and cytological specimens for microscopic and macroscopic examinations, namely microtomes and microtome blades; coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines, staining machines, and tissue processing apparatus, all the aforementioned goods being laboratory apparatus for histology and cytology.

Goods & Services

Laboratory instruments for the detection of pathogens and toxins in a biological sample for research use; microtomes; ultramicrotomes; separating apparatus for laboratory use; artificial intelligence software; machine learning software; virtual assistant software; artificial intelligence software and machine learning software; biometric software; production support software; sensory software; adaptive software; assistive software; engineering software; three-dimensional image manipulators [software]. Disposable microtome blades; scientific, pathological and clinical laboratory apparatus and equipment for use in connection with medical analysis, diagnosis and research; scientific and diagnostic laboratory apparatus and accessories for collecting, preparing, cutting, sectioning, holding and placing histological and cytological specimens for microscopic and macroscopic examinations, namely microtomes and microtome blades.

Goods & Services

Scientific, precision mechanical, optical, electronic apparatus and instruments; systems and apparatus for 2D and/or 3D microscopy and related software; systems and apparatus for measuring microscopy and related software; microscopes, in particular optical microscopes; stereo microscopes; routine microscopes; optical microscopes; measuring microscopes; microscope imaging system; autofocus microscopes; microscopes with autofocus; laser micro-dissection apparatus; image analysis apparatus; electronic image recording, image storage and image displaying apparatus; parts of the aforementioned apparatus and devices; lenses; objectives; objective holders; lens tubes and containers for microscope slides; microscope video processors; microscope cameras; cameras for use with microscopes; optical systems for microscopes; lighting devices for optical instruments; lighting for microscopes; ring lights for use with microscopes; software for the aforesaid apparatus and devices, software for image analysis and recording for microscopes; operating system software for automated microscopes; software for operational processes in and between scientific and medical institutions; software for training and advertising purposes; lighting control software for commercial and industrial facilities; computer software for use with microscopes; software for measuring microscopy; analysis software for use with microscopes; software for imaging solutions; platforms and software for (digital) microscopes; computer software for processing digital images; computer software for data and image acquisition and processing for use with microscopes.

Goods & Services

Cameras for imaging in optical microscopy; cameras for fluorescence imaging; cameras for stereoscopic imaging; cameras for fluorescence imaging in life sciences and biological sciences; cameras for quality control and documentation.

Abstract

A sample transfer device (100) for receiving a sample inside the sample transfer device (100) and for transferring the sample to a processing or analysing unit includes a connection opening (110) defining a transfer path (114) along which the sample is to be transferred from a loading position (120) of the sample inside the sample transfer device (100) through the connection opening (110), a shutter (130) configured to block the connection opening (110) or to unblock the connection opening (110), and a shielding member (140) configured to be arranged between the connection opening (110) and the loading position (120) to protect the sample from an incoming gas stream when the shutter (130) unblocks the connection opening (110).

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• H01J 37/20 - Means for supporting or positioning the object or the materialMeans for adjusting diaphragms or lenses associated with the support

Abstract

A system (100) for loading a sample into and/or manipulating a sample in a sample transfer device (180) at cryogenic temperatures, comprising the sample transfer device (180) being configured to receive a sample through a receiving opening (182) of the sample transfer device (180) and configured to transfer the sample to a processing or analysing unit, and a dry box (110) having an interface opening (112) and being configured to be coupled to the sample transfer device (180) such that the interface opening (112) of the dry box (110) is located opposite the receiving opening (182) of the sample transfer device (180).

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• B01L 1/02 - Air-pressure chambersAir-locks therefor

Goods & Services

Display devices; head mounted displays; head mounted 3D stereoscopic displays; head-mounted display devices for surgery or for surgical microscopy.

Abstract

A method (1000) for producing a section ribbon (800) from a sample block (700) using a microtome (100) comprising a blade (304) is disclosed, wherein the section ribbon (800) is produced to comprise a first part ribbon with one or more first sections (802) of the sample block (700) and a second part ribbon with one or more second sections (804) of the sample block (700), wherein the first part ribbon is produced from a first surface region (703) of the sample block (700) and the second part ribbon is produced from a second surface region (705) of the sample block (700), the second surface region (705) being different from the first surface region (703), and wherein the sample block (700) is retracted from the blade (304) between producing the first part ribbon and the second part ribbon. A method (900) for preparing a microscopic sample (600) for examination in an electron microscope, a microtome (100) and an embedding mould (500) are also disclosed.

IPC Classes  ?

• G01N 1/36 - Embedding or analogous mounting of samples
• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome

Goods & Services

Display devices being computer display monitors, LCDs; head mounted video displays; head mounted 3D stereoscopic displays

Abstract

A method (400) for microscopic examination of a sample (1) includes applying (410) the sample (1) to a sample holder (10) having a transparent carrier material, capturing (420) a first image (210, 220) of the sample (1) applied to the sample holder (10) using a first light-microscopy method, cryofixing, freeze-substituting, and subsequently infiltrating and embedding (430) the sample (1) together with the sample holder (10) with an embedding medium (20) in an embedding mold (90, 100), curing (440) the embedding medium (20), removing the sample (1) from the embedding mold (90, 100) together with the embedding medium (20) and the sample holder (10), capturing (450) a second image (230) of the sample (1) embedded in the cured embedding medium (20) using a second light-microscopy method, wherein at least partially identical regions of the sample (1) are captured in the first and second images, and identifying (460) at least one portion of the first image (210, 220) and one portion of the second image (230) which show identical regions of the sample (1).

IPC Classes  ?

• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G01N 1/28 - Preparing specimens for investigation
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• G01N 21/64 - FluorescencePhosphorescence
• G01N 23/04 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and forming images of the material
• G01N 23/06 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by transmitting the radiation through the material and measuring the absorption

Goods & Services

Scientific apparatus and instruments, namely, Ionization apparatus for scientific or laboratory use, Stills for scientific purposes, Glass tubes for scientific purposes; microscopes; microscope parts and components, namely, Reflectors for microscopes, Body-tubes for microscopes, Lenses for microscopes; microscopes for operations, not for surgical or medical use; microscopes and microscopes for operation, not for surgical or medical use; microscopes for operations, for surgical use; microscopes for operations, for eye surgery; optical systems for microscopes comprised of Microscope condensers, Prisms, Lenses for microscopes, 3D scanners for integrated optical coherence tomography; parts and accessories in the nature of structural parts and fittings for all the aforesaid apparatus and instruments; microscopic imaging systems comprised of Microscopes and parts thereof, Thermal imaging cameras, Laboratory equipment, namely, microscope slides; accessories for microscopes, namely, Reflectors for microscopes, Body-tubes for microscopes, Lenses for microscopes; apparatus and systems for 3D microscopy and associated software, namely, automated microscope and recorded operating software sold as a unit for use in laboratory operations; cameras, head-up displays (HUDs) in the nature of transparent electronic displays and battery monitors for use in microscopes and surgical microscopes; display units, namely, Light emitting diode (LED) displays, Liquid crystal displays, Electronic numeric displays; head-mounted display devices, namely, Head-mounted video displays, Video displays mounted in eyeglasses, Optical devices, namely, eye pieces for helmet mounted displays; stereoscopic 3D video screens for head mounting; downloadable and recorded computer software for use with microscopes for operating microscopes, uploading images, processing information; downloadable and recorded computer software for capturing and processing data and images for use with microscopes and microscopes for operations; downloadable and recorded computer software for microscopes and microscopes for operations for operating microscopes, uploading images, processing information Surgical imaging devices, namely, medical imaging apparatus; surgical microscopic imaging systems comprised of Microscopes for surgical operations, medical imaging apparatus, Medical imaging transducers, headsets specially adapted for medical purposes for endoscopy and surgery; ophthalmological apparatus and instruments, namely, Eye testing machines and apparatus, Medical imaging devices for eyes, Eye protectors for post-surgery eye protection Design and development of computer hardware and software for microscopes and surgical microscopes; scientific and technological services, namely, scientific research, analysis, testing in the field of microscopy as well as design and development of computer hardware and software Advisory and information services with respect to medical products, namely, providing information concerning the use of medical diagnostic imaging equipment by means of a web site; medical services; medical equipment rental; provision of medical facilities, namely, Medical clinics

Goods & Services

Cameras for imaging in optical microscopy; cameras for fluorescence imaging; cameras for stereoscopic imaging; cameras for fluorescence imaging in life sciences and biological sciences; cameras for quality control and documentation

Goods & Services

Scientific, precision mechanical, optical, electronic apparatus and instruments, namely, Probes for scientific purposes, Prisms for optics purposes, Precision instruments for manipulation and positioning of microscopic objects; systems comprised of an apparatus for 2D and 3D microscopy and related software, namely, automated microscope and recorded or downloadable operating software sold as a unit for use in laboratory operations; systems comprised of and apparatus for measuring microscopy and related software, namely, automated microscope and recorded operating software sold as a unit for use in laboratory operations; microscopes, in particular optical microscopes; stereo microscopes; routine microscopes; optical microscopes; measuring microscopes; microscope imaging system comprised of Microscopes and parts thereof, Thermal imaging cameras, Laboratory equipment, namely, microscope slides; autofocus microscopes; microscopes with autofocus; Laser equipment for non-medical purposes, namely, laser micro-dissection apparatus; image analysis apparatus, namely, scanner for capturing images for analysis for use in the life science research field; electronic image recording, image storage and image displaying apparatus, namely, Apparatus for recording of images, Blank electronic storage media, Liquid crystal displays; structural parts of the aforementioned apparatus and devices; lenses, namely, Lenses for microscopes, Contact lenses, Magnifying lenses, Eyeglass lenses; Microscope objectives; Microscope objective holders; lens tubes and containers for microscope slides, namely, body-tubes for microscopes and cover glass for microscope slides; microscope video processors; microscope cameras; cameras for use with microscopes; optical systems for microscopes comprised of Microscope condensers, Prisms, Lenses for microscopes; lighting devices for optical instruments, namely, Microscope illuminating devices, Lights for use with computer, video, and microscope cameras, Light systems comprising light sensors and switches; Microscope illuminating devices, namely, lighting for microscopes; Microscope illuminating devices, namely, ring lights for use with microscopes; downloadable and recorded software for the aforesaid apparatus and devices for operating microscope cameras, uploading images, processing data from microscopes; downloadable and recorded software for image analysis and recording for microscopes; recorded operating system software for automated microscopes; downloadable and recorded software for performing operational processes in and between scientific and medical institutions; downloadable and recorded software for training and advertising purposes for accessing training videos, creating advertising designs, uploading images; downloadable and recorded lighting control software for controlling lighting in commercial and industrial facilities; downloadable and recorded computer software for use with microscopes for operating microscopes, uploading images, processing information; downloadable and recorded software for measuring microscopy; downloadable and recorded analysis software for use with microscopes for analyzing images and data; downloadable and recorded software for imaging solutions for uploading and sharing images, processing images, editing images; Downloadable and recorded computer software platforms and software for digital microscopes for operating microscopes, uploading images, processing information; downloadable and recorded computer software for processing digital images; downloadable and recorded computer software for data and image acquiring and processing for use with microscopes

Goods & Services

Laboratory instruments for the detection of pathogens and toxins in biological specimens for research purposes; microtomes; ultramicrotomes being microtomes; scientific apparatus, namely, freezers for fixing cell specimens; scientific apparatus, namely, freezers for fixing microscopic specimens; downloadable, recorded machine learning software for organizing and viewing digital images and photographs; three-dimensional image manipulators, namely, downloadable, recorded computer programs for editing three-dimensional images Medical instruments being disposable microtome blades; scientific and diagnostic laboratory apparatus and accessories for collecting, preparing, cutting, sectioning, holding and placing histological and cytological specimens for microscopic and macroscopic examinations, namely, microtomes and microtome blades

Goods & Services

Laboratory instruments for the detection of pathogens and toxins in biological specimens for research purposes; microtomes; ultramicrotomes being microtomes; scientific apparatus, namely, freezers for fixing cell specimens; scientific apparatus, namely, freezers for fixing microscopic specimens; downloadable, recorded machine learning software for organizing and viewing digital images and photographs; three-dimensional image manipulators, namely, downloadable, recorded computer programs for editing three-dimensional images Medical instruments being disposable microtome blades; scientific and diagnostic laboratory apparatus and accessories for collecting, preparing, cutting, sectioning, holding and placing histological and cytological specimens for microscopic and macroscopic examinations, namely, microtomes and microtome blades

Goods & Services

Display devices; head mounted displays; head mounted 3D stereoscopic displays; head-mounted display devices for surgery or for surgical microscopy.

Goods & Services

Scientific apparatus and instruments for scientific research in laboratories; scientific apparatus and equipment, namely, scientific laboratory workstations and associated computer software used for protein, nucleic acid or immunoassay analysis in the fields of in-vitro diagnostics and biomedical diagnosis; computer operated automation systems comprised of computer hardware and operating software for laboratory instruments; laboratory instruments for specimen preparation; automated immunostainers for laboratory use; laboratory equipment for use in specimen preparation, namely, tissue processors; haematology slide makers and stainers for placing a barrier on a slide for use in scientific research; clinical chemistry instruments for laboratory use, namely, clinical chemistry analyzers; random access clinical chemistry analysers for the analysis of biological samples for scientific research purposes; laboratory instruments, namely, immunoassay clinical analysers; histopathology instruments, tissue processors and haematology instruments used in scientific research for processing biological samples; scientific laboratory apparatus for histology and cytology, namely coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines, automatic colouring machines, staining machines with immunological responses; tissue processors for processing biological samples for laboratory use; multiwell plates, for use in the following fields: chemical analytical services, laboratory research services; cryostats for laboratory use; cryomacrotomes, for laboratory use; automatic slide scanners; laboratory equipment and supplies for collecting, preparing, holding and filing of histological and cytological specimens for microscopic, magnetic resonance, tomosynthesis, ultra-sound or x-ray examination, namely, sample containers, specimen containers, sample cassettes, biopsy cassettes; label printer for printing labels for sample cassettes and biopsy cassettes; barcode reader for reading the printed labels on sample cassettes and biopsy cassettes; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples; microtomes, microtome blades, for use in the following fields: histology laboratories, not for medical purposes; ultramicrotomes and ultramicrome blades, diamond knives, glass knives, glass breaker for preparing glass knives for laboratory use; physical and optical apparatus and instruments; enlargers; electronic and electrical apparatus and instruments for storing, transmitting and processing date; precision scientific and optical apparatus and instruments, projection apparatus; microscopes; microphotographic apparatus; digital microscopes; microscopes for operations; micro projection apparatus and micromanipulators, microtomes, microscopic and microtomic hot or cold object tables (laboratory apparatus); microscopes for medical use; automated microscopes; optical light microscopes; laser scanning microscopes; measuring microscopes; photomicroscopes; confocal laser microscopes; tirf microscopes; routine microscopes; life science research microscopes; clinical microscopes; microscope platforms; digital microscopes, especially, digital microscopes for routine inspection work; digital microscopes, especially, digital microscopes for quality control; digital microscopes for routine inspection processes for research and development work; microscope systems; microscope systems for digital inspection, observation and measurement; laser scanning microscopy; laser microdissection apparatus; eyepieces for projection, microscopes and measuring technology; macroscopes, photo macroscopes; microtomes in particularly ultramicrotomes, cryomicrotomes, electronic microlithography apparatus and instruments; surgical microscopes; parts and components of surgical microscopes; multispectral fluorescence imaging systems; parts and components of multispectral fluorescence imaging systems; optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; systems and apparatuses for performing multispectral fluorescence microscopy and associated software; systems and apparatuses for performing 3d microscopy or multispectral fluorescence imaging and associated software; medical devices and instruments, namely microscopes and microscopes for operations; digital image capture and data processing apparatus for use in the medical sector; operating microscopes for use in surgery; operating microscopes for use in minimally invasive surgery and microsurgery; operating microscopes for use in neurosurgery; operating microscopes for use in ophthalmology; operating microscopes for use in the ent region; operating microscopes for use in dentistry; parts and fittings for all such apparatus and instruments; tissue cutting tools and micro and macro tissue grossing stations for laboratory use; fume hoods for specimen preparation for laboratory use; microscopic slides and cover glass; cover tiles for immunostainers; specimen embedding cassettes; specimen embedding stations for laboratory use; slide and specimen cassette electric printers; image analysis apparatus, namely, reading and writing devices for codes of multiwell plates, cassettes, slides, sample carriers, namely, barcode scanners, storing and transporting devices, namely blank hard drives for computers; software for tracking the location of histological and cytological specimens; software operating for histological and cytological scientific and diagnostic apparatus and laboratory equipment; computer software for digitizing microscope slides for viewing, integration with other data, management, and analysis, all in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; automated digital scanning system comprised of computer hardware and operating software integrating optical microscopy, motorized sample positioning, digital image capture, data processing, manipulation and display for use in scanning and digitizing microscope samples in research and clinical environments; digital slide information management software for digitizing entire glass microscope slides into diagnostic quality images displayed in context with reports, case histories and other associated documents, cross-linked and concurrently viewable for use in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; precision optical components; scientific, optical and measuring apparatus and instruments; parts for all the aforesaid goods, in particular exchangeable components and assemblies; accessories, namely bellows adjustment apparatus, adapters, angle finders, protective lids, daylight boxes, magazines, cassettes, micro and macro-projection attachments, lighting devices for microscopes; software for use with microscopes; analysis software for the use with microscopes without external apparatus; digital microscope cameras with software for microscopes; software operating systems for digital microscopes; software for use with the aforesaid hardware, especially, operating software, image analysis software, image storage software, software for operational processes in and between scientific and medical devices, software for documentation and analysis in life science, clinical and industrial applications; downloadable software for processing digital images; downloadable sample recognition software for identifying and extracting interesting characteristics from digital images; downloadable sample recognition software for processing digital images; computer software for mobile data processing apparatus; computer software for mobile data processing apparatus for remote data connection to a microscope or operating microscope or microscopic camera or operating microscopic camera; computer software for connection to a mobile data processing apparatus with a camera for image capture, adaptation, alteration, archiving or sharing live images or recorded images; computer software for providing live images from a variety of image sources; computer software for using a data processing apparatus as image source; software for use with microscopes, surgical microscopes, multispectral fluorescence imaging systems and with optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; computer software for data and image capture and processing for use with microscopes and operating microscopes; computer software for microscopes and operating microscopes. Surgical, medical, dental and veterinary apparatus and instruments; medical apparatus, in particular, histopathology instruments, tissue processors and haematology instruments for clinical purposes, namely tissue staining instruments for staining; medical diagnostic apparatus and instruments, in particular, diagnostic medical apparatus for performing immuno-histochemistry and in situ-hybridisation staining reactions, and histological and pathological staining; medical apparatus for dns in situ hybridisation probes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covers; medical instruments, needles, probes, and devices for the purpose of tissue biopsy or tissue removal from glands and/or organs in the human body; surgical devices, namely vacuums for breast biopsies, namely automated slide stainers for use in medical laboratories; multiwell plates, for use in the following fields: medical research; biopsy site markers; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples, namely, sample preparation device for medical diagnostic uses; ophthalmological apparatus and instruments, especially refractometers, tonometers, keratometers, projection apparatus for medical use; ophthalmological apparatus and devices, in particular refractometers, tonometers, keratometers, drawing projectors; systems consisting of the above apparatus and instruments. Maintenance and repair of scientific apparatus and equipment; maintenance and repair of pathology and clinical laboratory apparatus; maintenance and repair of computer operated automation systems for laboratory instruments; maintenance and repair of precision engineering, optical, electro-acoustic and ophthalmological apparatus and systems; conducting of maintenance and repair of the aforesaid goods for the aforesaid applications; maintenance and repair of precision, optical, photographic, photogrammetric, physics, measuring, electrotechnical, electronic, optronic, electro-acoustic and ophthalmologic apparatus, instruments and systems. Arranging of multimedia presentations, training courses and lectures, publication of application technology and product-related information and scientific data; practical training [demonstration]; conducting workshops [training]. Scientific and technological services, scientific and technological research, drafting services, development, in relation to the following goods: computer hardware, computer software; drafting services, development, in relation to the following goods: software, especially, software for [digital] microscopes; development of software for microscope analysis tasks; development of software for digital image analysis systems for microscopic examination and analysis; development of data processing programmes for scientific, optical and electronic apparatus and devices; design of data processing programs; scientific and technological services, namely, research and design in the field of testing, analyzing, examining or storing biological samples, medical samples, and cell samples; industrial analysis and research services namely, scientific research services for medical purposes, laboratory biological research, clinical biological research, biological research and research relating to the testing of biological samples, medical samples, and cell samples; creation of computer programs for the data processing of scientific, optical and electronic apparatuses and devices; creation of computer programs for use in providing data processing for scientific, diagnostic, research or laboratory purposes for use in microtomes, ultramicrotomes, cryomicrotomes, cryostats, macrotomes, cryomacrotomes, telepathology devices, automatic slide scanners; development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines; development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, staining machines, staining machines with immunological responses, contrasting machines, glass knife breakers, high-pressure freezing devices for microscopic sample preparation, and sample carriers for microscopic preparations; scientific consultation, namely, technical advice for scientific and medical institutions with respect to the application of scientific, diagnostic, research and laboratory optical and electronic apparatuses and devices, not to include medical consultations; maintenance and repair of scientific devices, namely, computer operating software for image analysis and image storage devices; maintenance and repair of computer operating software for image analysis and image storage devices; operation of scientific or medical laboratories as a service; provision of software to customers in a software as a service model; technical research; engineering services; geological surveys; surveying; land surveying; geological research; computer programming; computer software design; consultancy in the design and development of computer hardware; maintenance of computer software; installation of computer software; updating of computer software; technical consultancy relating to the use of scientific, optical and electronic apparatus and devices; technical consultancy relating to the use of scientific, optical and electronic apparatus and devices, in particular for scientific and medical facilities.

Goods & Services

Scientific, precision engineering, optical and electronic apparatus; systems and apparatus for 2D and/or 3D microscopy and associated software; systems and apparatus for measurement microscopy and associated software; microscopes; optical microscopes; measurement microscopes; microscopic imaging system; LED microscopes; autofocus microscopes; microscopes with autofocus; microscope parts and components; optical systems for microscopes; lighting devices for optical instruments; lighting for microscopes; ring-shaped lighting for microscopes; lenses for microscopes; lenses (objectives) for microscopes; microscope cameras; cameras for use with microscopes; microscope cameras with motorized autofocus; 2K, 4K, 8K or 12K resolution cameras, with or without autofocus, for use with microscopes; cameras for optical microscope shots; computer software for use with microscopes; software for measurement microscopy; analytical software for use with microscopes; software for imaging solutions; platforms and software for microscopes (digital); computer software for processing digital images; computer software for acquiring and processing data and images, for use with microscopes.

Goods & Services

Scientific, precision engineering, optical and electronic apparatus, namely, Probes for scientific purposes, Prisms for optics purposes, Precision instruments for manipulation and positioning of microscopic objects; systems comprised of and apparatus for 2D and 3D microscopy and associated software, namely, automated microscope and recorded and downloadable operating software sold as a unit for use in laboratory operations; systems comprised of an apparatus for measurement microscopy and associated software, namely, automated microscope and recorded and downloadable operating software sold as a unit for use in laboratory operations; microscopes; optical microscopes; measurement microscopes; microscopic imaging system; LED microscopes; autofocus microscopes; microscopes with autofocus; microscope parts and components; optical systems for microscopes comprised of Microscope condensers, Prisms, Lenses for microscopes; lighting devices for optical instruments, namely, Microscope illuminating devices, Lights for use with computer, microscope and video cameras, Light systems comprising light sensors and switches; Microscope illuminating devices, namely, lighting for microscopes; Microscope illuminating devices, namely, ring-shaped lighting for microscopes; lenses for microscopes; lenses in the nature of objectives for microscopes; microscope cameras; cameras for use with microscopes; microscope cameras with motorized autofocus; 2K, 4K, 8K or 12K resolution cameras, with or without autofocus, for use with microscopes; cameras for optical microscope shots; downloadable and recorded computer software for use with microscopes for operating microscopes, uploading images, processing information; downloadable and recorded software for measurement microscopy, namely for measuring microscopy; downloadable and recorded analytical software for use with microscopes for analyzing images and data; downloadable and recorded software for imaging solutions for uploading and sharing images, processing images, editing images; Downloadable and recorded computer software platforms and software for microscopes for operating microscopes, uploading images, processing information; downloadable and recorded computer software for processing digital images; downloadable and recorded computer software for acquiring and processing data and images, for use with microscopes

Goods & Services

Scientific, precision engineering, optical and electronic apparatus; systems and apparatus for 2D and/or 3D microscopy and associated software; systems and apparatus for measurement microscopy and associated software; microscopes; optical microscopes; measurement microscopes; microscopic imaging system; LED microscopes; autofocus microscopes; microscopes with autofocus; microscope parts and components; optical systems for microscopes; lighting devices for optical instruments; lighting for microscopes; ring-shaped lighting for microscopes; lenses for microscopes; lenses (objectives) for microscopes; microscope cameras; cameras for use with microscopes; microscope cameras with motorized autofocus; 2K, 4K, 8K or 12K resolution cameras, with or without autofocus, for use with microscopes; cameras for optical microscope shots; computer software for use with microscopes; software for measurement microscopy; analytical software for use with microscopes; software for imaging solutions; platforms and software for microscopes (digital); computer software for processing digital images; computer software for acquiring and processing data and images, for use with microscopes.

Goods & Services

Scientific apparatus and instruments for scientific research in laboratories, NAMELY, optical mirrors; scientific apparatus and equipment, namely, scientific laboratory computer workstations comprising a processor and memory and downloadable and recorded computer software used for protein, nucleic acid or immunoassay analysis in the fields of in-vitro diagnostics and biomedical diagnosis; computer operated automation systems comprised of computer hardware and recorded and downloadable operating software for laboratory instruments; laboratory instruments for specimen preparation, NAMELY, laboratory swabs; automated immunostainers for laboratory use; laboratory equipment for use in specimen preparation, namely, tissue processors; haematology slide makers and stainers for placing a barrier on a slide for use in scientific research; clinical chemistry instruments for laboratory use, namely, clinical chemistry analyzers for analyzing air; random access clinical chemistry analysers for the analysis of biological samples for scientific research purposes; laboratory instruments, namely, immunoassay clinical analyzers for analyzing biological specimens; histopathology instruments, tissue processors and haematology instruments used in scientific research for processing biological samples; scientific laboratory apparatus for histology and cytology, namely, coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines, automatic colouring machines, staining machines with immunological responses; tissue processors for processing biological samples for laboratory use; multiwell plates, for use in chemical analytical services, laboratory research services; cryostats for laboratory use; cryomacrotomes, for laboratory use; automatic slide scanners not for medical or veterinary use; laboratory equipment and supplies for collecting, preparing, holding and filing of histological and cytological specimens for microscopic, magnetic resonance, tomosynthesis, ultra-sound or x-ray examination, namely, sample containers, specimen containers, sample cassettes, biopsy cassettes not for medical or veterinary use; label printer for printing labels for sample cassettes and biopsy cassettes; barcode reader for reading the printed labels on sample cassettes and biopsy cassettes; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples not for medical or veterinary use; microtomes, microtome blades, for use in histology laboratories, not for medical purposes; ultramicrotomes and ultramicrome blades, diamond knives, glass knives, glass breaker for preparing glass knives for laboratory use; physical and optical apparatus and instruments, NAMELY, optical mirrors; enlargers, NAMELY, copy machines; electronic and electrical apparatus and instruments for storing, transmitting and processing data; precision scientific and optical apparatus and instruments, NAMELY, Slide or photograph projection apparatus; microscopes; digital microscopes; microscopes for operations; micro projection apparatus and micromanipulators, microtomes, microscopic and microtomic hot or cold object tables being laboratory apparatus; microscopes for medical use; automated microscopes; optical light microscopes; laser scanning microscopes; measuring microscopes; photomicroscopes; confocal laser microscopes; tirf microscopes; routine microscopes; life science research microscopes; clinical microscopes; microscope platforms being replacement parts for microscopes; digital microscopes, especially, digital microscopes for routine inspection work; digital microscopes, especially, digital microscopes for quality control; digital microscopes for routine inspection processes for research and development work; microscope systems comprised of microscope and computer hardware; microscope systems comprised of microscope and computer hardware for digital inspection, observation and measurement; laser scanning microscopy; laser microdissection apparatus; eyepieces being replacement parts for projection, microscopes and measuring technology, NAMELY, microscopes; macroscopes, photo macroscopes; microtomes in particularly ultramicrotomes, cryomicrotomes, electronic microlithography apparatus and instruments; surgical microscopes; replacement parts and components of surgical microscopes; multispectral fluorescence imaging systems comprised of camera and computer hardware; replacement parts for multispectral fluorescence imaging systems; optical systems for microscopes comprised of mirrors and computer hardware, surgical microscopes and multispectral fluorescence imaging systems comprised of cameras and computer hardware; systems and apparatuses for performing multispectral fluorescence microscopy comprised of microscope and computer hardware and associated downloadable and recorded software for performing multispectral fluorescence microscopy; systems and apparatuses for performing 3d microscopy or multispectral fluorescence imaging comprised of microscope and computer hardware and downloadable and recorded software for performing 3d microscopy or multispectral fluorescence imaging; digital image capture and data processing apparatus for use in the medical sector, NAMELY, Nuclear medical research imaging apparatus; operating microscopes for use in surgery; operating microscopes for use in minimally invasive surgery and microsurgery; operating microscopes for use in neurosurgery; replacement parts for all such apparatus and instruments; tissue cutting tools and micro and macro tissue grossing stations for laboratory use; fume hoods for specimen preparation for laboratory use; microscopic slides and cover glass for scientific, laboratory or medical research use; cover tiles for immunostainers; specimen embedding cassettes for scientific, laboratory or medical research use; specimen embedding stations for laboratory use; slide and specimen cassette electric printers; image analysis apparatus, namely, reading and writing devices for codes of multiwell plates, cassettes, slides, sample carriers, namely, barcode scanners, storing and transporting devices, namely, blank hard drives for computers; downloadable and recorded software for tracking the location of histological and cytological specimens; downloadable and recorded software operating for histological and cytological scientific and diagnostic apparatus and laboratory equipment; downloadable and recorded computer software for digitizing microscope slides for viewing, integration with other data, management, and analysis, all in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; automated digital scanning system comprised of computer hardware and downloadable and recorded operating software for integrating optical microscopy, motorized sample positioning, digital image capture, data processing, manipulation and display for use in scanning and digitizing microscope samples in research and clinical environments; downloadable and recorded digital slide information management software for digitizing entire glass microscope slides into diagnostic quality images displayed in context with reports, case histories and other associated documents, cross-linked and concurrently viewable for use in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; precision optical components, NAMELY, optical mirrors; scientific, optical and measuring apparatus and instruments, NAMELY, optical mirrors; replacement parts for all the aforesaid goods, in particular exchangeable components and assemblies; microscopes accessories, namely, bellows adjustment apparatus, adapters, angle finders, protective lids, daylight boxes, micro and macro-projection attachments, lighting devices for microscopes; downloadable and recorded software for use with microscopes for recording images; downloadable and recorded analysis software for the use with microscopes without external apparatus for recording images; digital microscope cameras with downloadable and, recorded software for recording images for microscopes; downloadable and recorded software operating systems for digital microscopes; downloadable and recorded software for use with the aforesaid hardware, NAMELY, operating software, image analysis software, image storage software, software for operational processes in and between scientific and medical devices, software for documentation and analysis in life science, clinical and industrial applications; downloadable software for processing digital images; downloadable sample recognition software for identifying and extracting interesting characteristics from digital images; downloadable sample recognition software for processing digital images; downloadable and recorded computer software for mobile data processing apparatus; downloadable and recorded computer software for mobile data processing apparatus for remote data connection to a microscope or operating microscope or microscopic camera or operating microscopic camera; downloadable and recorded computer software for connection to a mobile data processing apparatus with a camera for image capture, adaptation, alteration, archiving or sharing live images or recorded images; downloadable and recorded computer software for providing live images from a variety of image sources; downloadable and recorded computer software for using a data processing apparatus as image source; downloadable and recorded software for use with microscopes, surgical microscopes, multispectral fluorescence imaging systems and with optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems for recording images; downloadable and recorded computer software for data and image capture and processing for use with microscopes and operating microscopes; computer software for microscopes and operating microscopes for recording images Surgical apparatus and instruments; medical imaging and radiation apparatus and instruments; dental apparatus and instruments, NAMELY, namely, reusable and recyclable prophy angle; veterinary instruments and apparatus being Surgical apparatus and instruments for veterinary use; medical apparatus, in particular, histopathology instruments, tissue processors and haematology instruments for clinical purposes, namely, tissue staining instruments for staining; medical diagnostic apparatus and instruments, in particular, diagnostic medical apparatus for performing immuno-histochemistry and in situ-hybridisation staining reactions, and histological and pathological staining for testing blood sugar levels, cancer cells, and DNA; medical apparatus for dns in situ hybridisation probes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covers for testing blood sugar levels, cancer cells, and DNA; medical instruments, NAMELY, needles, probes, and devices for the purpose of tissue biopsy or tissue removal from glands and/or organs in the human body; surgical devices, namely, vacuums for breast biopsies, namely, automated slide stainers for use in medical laboratories; multiwell plates, for use in medical research for medical specimen collection; biopsy site markers; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples, namely, sample preparation device for medical diagnostic uses; ophthalmological apparatus and instruments, especially refractometers, tonometers, keratometers, projection apparatus for medical use; ophthalmological apparatus and devices, in particular refractometers, tonometers, keratometers, drawing projectors Maintenance and repair of scientific electronic apparatus and equipment; maintenance and repair of pathology and clinical laboratory apparatus; maintenance and repair of computer operated automation hardware systems for laboratory instruments; maintenance and repair of precision engineering, optical, electro-acoustic and ophthalmological apparatus and hardware systems; maintenance and repair of precision, optical, photographic, photogrammetric, physics, measuring, electrotechnical, electronic, optronic, electro-acoustic and ophthalmologic apparatus, instruments and hardware systems Arranging of multimedia presentations, training courses and lectures in the field of biology and microscopy; publication of brochures and books in the field of computer application technology and product-related information and scientific data in the field of biology, microscopy and computer hardware; practical training demonstration in the field of biology and microscopy; conducting workshops being training in the field of biology Scientific research and technological research and consulting services, scientific and technological research, drafting services, development, in relation to the following goods: computer hardware, computer software; drafting of plans and engineering drawings for others, software and product development, in relation to software, especially, software for digital microscopes; development of software for microscope analysis tasks; development of software for digital image analysis systems for microscopic examination and analysis; development of data processing programmes for scientific, optical and electronic apparatus and devices; design of data processing programs; scientific and technological services, namely, research and design in the field of testing, analyzing, examining or storing biological samples, medical samples, and cell samples; industrial analysis and research services, namely, scientific research services for medical purposes, laboratory biological research, clinical biological research, biological research and research relating to the testing of biological samples, medical samples, and cell samples; creation of computer programs for the data processing of scientific, optical and electronic apparatuses and devices; creation of computer programs for use in providing data processing for scientific, diagnostic, research or laboratory purposes for use in microtomes, ultramicrotomes, cryomicrotomes, cryostats, macrotomes, cryomacrotomes, telepathology devices, automatic slide scanners; development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines; development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, staining machines, staining machines with immunological responses, contrasting machines, glass knife breakers, high-pressure freezing devices for microscopic sample preparation, and sample carriers for microscopic preparations; scientific consultation, namely, technological advice for scientific and medical institutions with respect to the application of scientific, diagnostic, research and laboratory optical and electronic apparatuses and devices, not to include medical consultations; maintenance and repair of scientific devices, namely, maintenance and repair of computer operating software for image analysis and image storage devices; maintenance and repair of computer operating software for image analysis and image storage devices; operation of scientific and medical laboratories as a service; provision of software to customers in a software as a service model, NAMELY, Software as a service (SAAS) services featuring software for image analysis; technical research in the field of microscopes; engineering services; geological surveys; surveying; land surveying; geological research; computer programming; computer software design; consultancy in the design and development of computer hardware; maintenance of computer software; installation of computer software; updating of computer software; technical consultancy relating to the use of scientific, optical and electronic apparatus and devices, NAMELY, hardware for microscopes; technical consultancy relating to the use of scientific, optical and electronic apparatus and devices, in particular for scientific and medical facilities, NAMELY, hardware for microscopes

Goods & Services

Microscopes; digital microscopes; microscope parts and components; operating microscopes; parts and components of operating microscopes; multispectral fluorescence imaging systems; parts and components of multispectral fluorescence imaging systems; optical systems for microscopes; microscopes for operations and multispectral fluorescence imaging systems; digital systems for microscopes; 3D systems for microscopes; virtual reality systems for microscopes; head-mounted displays for use with microscopes; augmented reality head-mounted displays for use in microscopes; head-up display devicess for use in microscopes; virtual reality glasses for use in microscopes; virtual reality software for use in microscopy; virtual and augmented reality software (for use in microscopes); virtual reality software for simulation; virtual reality software for microscopy; 3D glasses for use with microscopes; augmented reality software for simulation; augmented reality software for use in microscopes; software for use with operating microscopes; multispectral fluorescence imaging systems for microscopes and optical systems for microscopes; systems and devices for multispectral fluorescence microscopy and associated software; systems and devices for performing 3D microscopy or multispectral fluorescence imaging and associated software; digital imaging software and solutions for use with operating microscopes; digital platforms and software for microscopes. Surgical imaging devices; surgical devices with multispectral fluorescence imaging systems. Design and development of computer hardware and software for operating microscopes; production of computer graphics (digital imaging services); design and development of virtual reality software for use with microscopes; software design for use with 3D microscopy.

Goods & Services

Scientific, precision engineering, optical and electronic apparatus, namely, downloadable or recorded software for 2D and/or 3D microscopy; downloadable or recorded software for measurement microscopy; downloadable or recorded software for microscopes, optical microscopes, measurement microscopes, LED microscopes, autofocus microscopes, microscopes with autofocus, microscope parts and components, namely, downloadable or recorded software for optical systems for microscopes, downloadable or recorded software for lighting devices for optical instruments, namely, ring-shaped lighting for microscopes, lenses for microscopes; lenses for microscopes, microscope cameras, cameras for use with microscopes, microscope cameras with motorized autofocus, 2K, 4K, 8K or 12K resolution cameras, with or without autofocus, for use with microscopes; cameras for optical microscope shots; downloadable or recorded computer software for use with microscopes for the performance of quality control and inspections; downloadable or recorded software for measurement microscopy; downloadable or recorded analytical software for use with microscopes for the performance of quality control and inspections; downloadable or recorded software for imaging solutions; downloadable or recorded platforms and software for microscopes; downloadable or recorded computer software for processing digital images; downloadable or recorded computer software for acquiring and processing data and images, for use with microscopes; none of the above to include software or software development for cash flow forecasting in the field of oil and gas field development planning

Abstract

The present invention concerns a method and a system for imaging at least a part of a specimen by means of two microscopy imaging methods, where a surface (11) of the specimen (10) is imaged by means of a first microscopy imaging method, where a replica (25) of the surface (11) to be imaged by means of the first microscopy imaging method is produced and this replica (25) is simultaneously imaged by means of a second microscopy imaging method, where the images produced by means of the first and the second microscopy imaging methods are overlaid at the correct scale.

IPC Classes  ?

• H01J 37/22 - Optical or photographic arrangements associated with the tube
• H01J 37/28 - Electron or ion microscopesElectron- or ion-diffraction tubes with scanning beams

Abstract

The invention relates to a processing system for use with optical coherence tomography imaging means for imaging a subject, the processing system being configured to repeatedly perform an image processing process (300), comprising the following steps: receiving (312) a scan data set from the subject (190) being acquired by means of optical coherence tomography, performing (314) data processing on the scan data set, including applying (316) dispersion correction based on a current set (370) of dispersion coefficients, and providing (318) a dispersion corrected image data set of the subject for an image of the subject to be displayed; and the processing system further being configured to repeatedly perform a dispersion coefficient adapting process (340), at least in part, in parallel to the image processing process (300), comprising the following steps: receiving (342) a scan data set from the subject being acquired by means of optical coherence tomography, adapting (344) dispersion coefficients by means of an optimization process (346) performed on the scan data set, and providing (348) a set (372) of adapted dispersion coefficients to be used to update the current set (370) of dispersion coefficients; and the processing system further being configured to update (350) the current set (370) of dispersion coefficients based on the set (372) of adapted dispersion coefficients, to an optical coherence tomography imaging system and a corresponding method.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions

Abstract

The invention relates to a control system (130) for controlling optical coherence tomography imaging means for imaging a subject (190), the control system being configured to perform the following steps: receiving scan data (122) from the subject (190) being acquired by means of optical coherence tomography, performing data processing on the scan data (122), and obtaining image data (142) for an image (144) of the subject, and the processing system (130) further being configured to adapting, based on a change of a value, the value characterizing an axial position (z) of the subject (190) with respect to the OCT imaging means, between two sets of image data, at least one parameter of the OCT imaging means, to a processing system, to an OCT imaging system (100) and a corresponding method.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection

Abstract

The invention relates to a processing system for use with optical coherence tomography imaging means for imaging a subject, the processing system being configured to perform the following steps: receiving (210) initial image data for an image of the subject acquired by means of optical coherence tomography, applying (214) a de-noising process to the image data in order to receive de-noised image data, combining (216) the de-noised image data with the image data, to which the de-noising process was applied, in order receive combined image data applying (218) a smoothing filter to the combined image data in order to receive smoothed image data, applying (220) a contrast enhancement process to the smoothed image data in order to receive contrast enhanced image data, and providing (230) final image data for the image of the subject to be displayed, to a further processing system, a control system for OCT, a OCT imaging system and corresponding methods.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06T 5/20 - Image enhancement or restoration using local operators
• G06T 5/40 - Image enhancement or restoration using histogram techniques

Abstract

The invention relates to a control system for controlling optical coherence tomography imaging means for imaging a subject, the control system being configured to perform the following steps of an imaging process: receiving (212) a scan data set from the subject being acquired by means of optical coherence tomography, the scan data set including one or several spectra (270), performing (214) data processing on the spectrum or on each of the several spectra of the scan data set (122), including per spectrum: determining (216) a scaling factor (274) for the spectrum (270, 370, 372, 374), scaling (218) a baseline spectrum (272) with a scaling factor (274), and removing (220) the scaled baseline spectrum (276) from the spectrum (270); and providing (224) a baseline corrected image data set of the subject for an image of the subject to be displayed, to an optical coherence tomography imaging system and to a corresponding method.

IPC Classes  ?

• G06T 5/00 - Image enhancement or restoration
• G06T 5/10 - Image enhancement or restoration using non-spatial domain filtering

Goods & Services

Microscopes; digital microscopes; multispectral fluorescence imaging systems comprised of microscopes, display monitors, downloadable or recorded software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; optical systems for microscopes comprised of microscopes, display monitors, downloadable or recorded software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices s; microscopes for operations and multispectral fluorescence imaging systems; digital systems for microscopes comprised of microscopes, display monitors, downloadable or recorded software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; 3D systems for microscopes comprised of microscopes, display monitors, downloadable or recorded software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; virtual reality systems for microscopes comprised of microscopes, display monitors, downloadable or recorded software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; head-mounted displays for use with microscopes; augmented reality head- mounted displays for use in microscopes; head-up display devices for use in microscopes; virtual reality glasses for use in microscopes; downloadable or recorded virtual reality software for use in microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; downloadable or recorded virtual and augmented reality software for use in microscopes for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; downloadable or recorded virtual reality software for simulation for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; downloadable or recorded virtual reality software for microscopy for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices;3D glasses for use with microscopes; downloadable or recorded augmented reality software for simulation for processing, capturing, recording or displaying images; downloadable or recorded augmented reality software for use in microscopes for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; downloadable or recorded software for use with operating microscopes; multispectral fluorescence imaging systems for microscopes and optical systems for microscopes comprised of microscopes, display monitors for multispectral fluorescence microscopy and associated downloadable or recorded software for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; systems comprised of microscopes for performing 3D microscopy or multispectral fluorescence imaging and associated downloadable or recorded software for processing, capturing, recording or displaying images, controlling a microscope or communicating with other devices; digital imaging downloadable or recorded software for use with operating microscopes; downloadable and/or recorded digital platforms; and downloadable or recorded software for use with microscopes that will allow the user to receive software updates and information about product advancements Surgical imaging devices, namely, surgical display monitors for use in direct association with surgical instruments during surgery, microscopes, endoscopes and Optical Coherence Tomographs; downloadable or recorded software for processing, capturing, recording or displaying images, controlling a surgical device or communicating with other devices for use with surgical display monitors for use in direct association with surgical instruments during surgery, microscopes, endoscopes and Optical Coherence Tomographs; surgical devices with multispectral fluorescence imaging systems comprised of surgical display monitors, microscopes, endoscopes and Optical Coherence Tomographs; downloadable or recorded software for processing, capturing, recording or displaying images, controlling a surgical device or communicating with other devices for use with surgical devices with multispectral fluorescence imaging systems comprised of surgical display monitors, microscopes, endoscopes and Optical Coherence Tomographs Design and development of computer hardware and software for operating microscopes; production of computer graphics; design and development of virtual reality software for use with microscopes; software design for use with 3D microscopy

Abstract

A device for preparing a microscopic sample for a high-pressure freezing process in which the sample is provided using an arrangement having a middle plate of a high-pressure freezing cartridge and an incubation chamber, the middle plate being attached to and detachable from the incubation chamber by effecting a relative movement between the middle plate and the incubation chamber, and the sample being provided on an enclosing element which is fitted into an opening of the middle plate, wherein the device includes an engagement structure adapted to engage with the middle plate and to restrict a movement of the middle plate while the incubation chamber is moved, such as to effect the relative movement between the middle plate and the incubation chamber and to thereby detach the middle plate from the incubation chamber.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
• C12M 1/00 - Apparatus for enzymology or microbiology

Goods & Services

Scientific apparatus and instruments; microscopes; microscopes for medical use; microscope parts and components; surgical microscopes; surgical microscope parts and components; microscopes for operations; surgical microscopes for eye surgery; microscopes and microscopes for operations; microscopes for operations, for surgical use; microscopes for operations, for eye surgery; microscopes and surgical microscopes with integrated OCT (optical coherence tomography) functions; optical systems for microscopes; parts and accessories for all the aforesaid apparatus and instruments; microscopic imaging systems; accessories for microscopes; apparatus and systems for 3D microscopy and associated software; cameras, head-up displays and monitors for use in microscopes and surgical microscopes; software for microscopes; computer software for capturing and processing data and images for use with microscopes and microscopes for operations; computer software for microscopes and microscopes for operations; accessories for surgical microscopy. Surgical imaging devices; surgical microscopic imaging systems; ophthalmological apparatus and instruments; medical devices and instruments. Design and development of computer hardware and software for microscopes and surgical microscopes; scientific and technological services as well as design and development of computer hardware and software. Consulting and information services relating to medical products; medical services; medical equipment rental; provision of medical facilities.

Abstract

A method including one or more steps of a procedure for preparing a microscopic sample for a high-pressure freezing process is provided, wherein the sample is provided using an arrangement comprising a middle plate of a high-pressure freezing cartridge and an incubation chamber, wherein the middle plate is attached to a lower surface of a bottom of the incubation chamber by an adhesive and detachable from the incubation chamber by effecting a relative movement between the middle plate and the incubation chamber, wherein the sample is provided on an enclosing element which is fitted into an opening of the middle plate, and wherein, when the sample is to be subjected to the high-pressure freezing process, the relative movement between the middle plate and the incubation chamber is effected, thereby detaching the middle plate with the sample from the incubation chamber. Means to implement the method are also part of the present disclosure.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• F25D 3/10 - Devices using other cold materialsDevices using cold-storage bodies using liquefied gases, e.g. liquid air
• C12M 1/00 - Apparatus for enzymology or microbiology

Abstract

The invention relates to a control system for an optical coherence tomography imaging system to be used with a microscopy system for viewing and/or imaging a subject (190, 192), the microscopy system comprising an objective (164) and a viewing lens system (170) including a relay lens (172), wherein the viewing lens system (170) is arranged at a subject's side of the objective (164), the control system being configured to perform the following steps: controlling the optical coherence tomography imaging system to perform at least one radial scan of a surface (176) of the relay lens (172), determining, from data of the at least one radial scan at least one curve corresponding to a shape of the surface (176) of the relay lens (172), determining (520), from the at least one curve a lateral offset (178) between a center of the relay lens (172) and an origin of the optical coherence tomography imaging system, and adjusting the origin of the optical coherence tomography imaging system taking into account to the lateral offset (178), to an arrangement with an OCT imaging system and a method for adjusting an OCT imaging system.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/13 - Ophthalmic microscopes
• A61B 3/15 - Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection
• G01B 11/24 - Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
• G02B 7/00 - Mountings, adjusting means, or light-tight connections, for optical elements
• G02B 21/00 - Microscopes
• G01B 9/02 - Interferometers

Goods & Services

Scientific apparatus and instruments for scientific research in laboratories; Scientific apparatus and equipment, namely, scientific laboratory workstations and associated computer software used for protein, nucleic acid or immunoassay analysis in the fields of in-vitro diagnostics and biomedical diagnosis; computer operated automation systems comprised of computer hardware and operating software for laboratory instruments; laboratory instruments for specimen preparation; automated immunostainers for laboratory use; laboratory equipment for use in specimen preparation, namely, tissue processors; haematology slide makers and stainers for placing a barrier on a slide for use in scientific research; clinical chemistry instruments for laboratory use, namely, Clinical chemistry analyzers; random access clinical chemistry analysers for the analysis of biological samples for scientific research purposes; Laboratory instruments, namely, immunoassay clinical analysers; histopathology instruments, tissue processors and haematology instruments used in scientific research for processing biological samples; Scientific laboratory apparatus for histology and cytology, namely Coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines, Automatic colouring machines, Staining machines with immunological responses; tissue processors for processing biological samples for laboratory use; multiwell plates, for use in the following fields: chemical analytical services, Laboratory research services; Cryostats for laboratory use; Cryomacrotomes, For laboratory use; automatic slide scanners; laboratory equipment and supplies for collecting, preparing, holding and filing of histological and cytological specimens for microscopic, magnetic resonance, tomosynthesis, ultra-sound or x-ray examination, namely, sample containers, specimen containers, sample cassettes, biopsy cassettes; label printer for printing labels for sample cassettes and biopsy cassettes; barcode reader for reading the printed labels on sample cassettes and biopsy cassettes; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples; Microtomes, Microtome blades, for use in the following fields: Histology laboratories, Not for medical purposes; ultramicrotomes and ultramicrome blades, diamond knives, glass knives, glass breaker for preparing glass knives for laboratory use; Physical and optical apparatus and instruments; Enlargers; electronic and electrical apparatus and instruments for storing, transmitting and processing date; precision scientific and optical apparatus and instruments, Projection apparatus; Microscopes; Microphotographic apparatus; Digital microscopes; Microscopes for operations; Micro projection apparatus and micromanipulators, Microtomes, Microscopic and microtomic hot or cold object tables (laboratory apparatus); Microscopes for medical use; Automated microscopes; Optical light microscopes; Laser scanning microscopes; Measuring microscopes; Photomicroscopes; Confocal laser microscopes; TIRF microscopes; Routine microscopes; Life science research microscopes; Clinical microscopes; microscope platforms; Digital microscopes, Especially, Digital microscopes for routine inspection work; Digital microscopes, Especially, Digital microscopes for quality control; Digital microscopes for routine inspection processes for research and development work; microscope systems; Microscope systems for digital inspection, observation and measurement; Laser scanning microscopy; Laser microdissection apparatus; Eyepieces for projection, microscopes and measuring technology; Macroscopes, photo macroscopes; Microtomes in particularly ultramicrotomes, cryomicrotomes, Electronic microlithography apparatus and instruments; Surgical microscopes; parts and components of surgical microscopes; multispectral fluorescence imaging systems; parts and components of multispectral fluorescence imaging systems; optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; systems and apparatuses for performing multispectral fluorescence microscopy and associated software; systems and apparatuses for performing 3D microscopy or multispectral fluorescence imaging and associated software; Medical devices and instruments, Namely microscopes and Microscopes for operations; Digital image capture and data processing apparatus for use in the medical sector; Microscopes for operations; Operating microscopes for use in surgery; Operating microscopes for use in minimally invasive surgery and microsurgery; Operating microscopes for use in neurosurgery; Operating microscopes for use in ophthalmology; Operating microscopes for use in the ENT region; Operating microscopes for use in dentistry; parts and fittings for all such apparatus and instruments; Tissue cutting tools and micro and macro tissue grossing stations for laboratory use; fume hoods for specimen preparation for laboratory use; microscopic slides and cover glass; cover tiles for immunostainers; specimen embedding cassettes; specimen embedding stations for laboratory use; slide and specimen cassette electric printers; Image analysis apparatus, namely, reading devices and writing devices for codes of multiwell plates, cassettes, slides, sample carriers, namely, bar-code scanners, storing and transporting devices, namely, blank hard drives for computers; software for tracking the location of histological and cytological specimens; software operating for histological and cytological scientific and diagnostic apparatus and laboratory equipment; computer software for digitizing microscope slides for viewing, integration with other data, management, and analysis, all in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; automated digital scanning system comprised of computer hardware and operating software integrating optical microscopy, motorized sample positioning, digital image capture, data processing, manipulation and display for use in scanning and digitizing microscope samples in research and clinical environments; digital slide information management software for digitizing entire glass microscope slides into diagnostic quality images displayed in context with reports, case histories and other associated documents, cross-linked and concurrently viewable for use in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; Precision optical components; Scientific, optical and measuring apparatus and instruments; Parts for all the aforesaid goods, in particular exchangeable components and assemblies; Accessories, Namely bellows adjustment apparatus, Adapters, angle finders, protective lids, daylight boxes, Magazines, Cassettes, micro and macro-projection attachments, Lighting devices for microscopes; software for use with microscopes; Analysis software for the use with microscopes without external apparatus; Digital microscope cameras with software for microscopes; Software operating systems for digital microscopes; Software for use with the aforesaid hardware, Especially, Operating software, image analysis software, image storage software, Software for operational processes in and between scientific and medical devices, Software for documentation and analysis in life science, clinical and industrial applications; downloadable software for processing digital images; Downloadable sample recognition software for identifying and extracting interesting characteristics from digital images; Downloadable sample recognition software for processing digital images; Computer software for mobile data processing apparatus; Computer software for mobile data processing apparatus for remote data connection to a microscope or operating microscope or microscopic camera or operating microscopic camera; computer software for connection to a mobile data processing apparatus with a camera for image capture, adaptation, alteration, archiving or sharing live images or recorded images; Computer software for providing live images from a variety of image sources; Computer software for using a data processing apparatus as image source; software for use with microscopes, surgical microscopes, multispectral fluorescence imaging systems and with optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; Computer software for data and image capture and processing for use with microscopes and operating microscopes; Computer software for microscopes and operating microscopes. Surgical, medical, dental and veterinary apparatus and instruments; Medical apparatus, in particular, histopathology instruments, tissue processors and haematology instruments for clinical purposes, namely tissue staining instruments for staining; Medical diagnostic apparatus and instruments, in particular, diagnostic medical apparatus for performing Immuno-histochemistry and In situ-hybridisation staining reactions, and histological and pathological staining; Medical apparatus for DNS in situ hybridisation probes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covers; medical instruments, needles, probes, and devices for the purpose of tissue biopsy or tissue removal from glands and/or organs in the human body; Surgical devices, Namely vacuums for breast biopsies; Namely automated slide stainers for use in medical laboratories; Multiwell plates, for use in the following fields: medical research; biopsy site markers; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples, namely, sample preparation device for medical diagnostic uses; Ophthalmological apparatus and instruments, especially refractometers, Tonometers, Keratometers, projection apparatus for medical use; Ophthalmological apparatus and devices, in particular refractometers, tonometers, keratometers, drawing projectors; systems consisting of the above apparatus and instruments. Maintenance and repair of scientific apparatus and equipment; maintenance and repair of pathology and clinical laboratory apparatus; maintenance and repair of computer operated automation systems for laboratory instruments; maintenance and repair of precision engineering, optical, electro-acoustic and ophthalmological apparatus and systems; Conducting of maintenance and repair of the aforesaid goods for the aforesaid applications; maintenance and repair of precision, optical, photographic, photogrammetric, physics, measuring, electrotechnical, electronic, optronic, electro-acoustic and ophthalmologic apparatus, instruments and systems. Arranging of multimedia presentations, training courses and lectures, publication of application technology and product-related information and scientific data; Practical training [demonstration]; Conducting workshops [training]. Science and technology services, Scientific and technological research, drafting services, Development, In relation to the following goods: Computer hardware, Computer software; drafting services, Development, In relation to the following goods: Software, Especially, Software for [digital] microscopes; Development of software for microscope analysis tasks; Development of software for digital image analysis systems for microscopic examination and analysis; Development of data processing programmes for scientific, optical and electronic apparatus and devices; Design of data processing programs; Scientific and technological services, namely, research and design in the field of testing, analyzing, examining or storing biological samples, medical samples, and cell samples; industrial analysis and research services namely, scientific research services for medical purposes, laboratory biological research, clinical biological research, biological research and research relating to the testing of biological samples, medical samples, and cell samples; creation of computer programs for the data processing of scientific, optical and electronic apparatuses and devices; creation of computer programs for use in providing data processing for scientific, diagnostic, research or laboratory purposes for use in microtomes, ultramicrotomes, cryomicrotomes, cryostats, macrotomes, cryomacrotomes, telepathology devices, automatic slide scanners; Development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines; Development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, staining machines, staining machines with immunological responses, contrasting machines, glass knife breakers, high-pressure freezing devices for microscopic sample preparation, and sample carriers for microscopic preparations; scientific consultation, namely, technical advice for scientific and medical institutions with respect to the application of scientific, diagnostic, research and laboratory optical and electronic apparatuses and devices, not to include medical consultations; maintenance and repair of scientific devices, namely, computer operating software for image analysis and image storage devices; maintenance and repair of computer operating software for image analysis and image storage devices; operation of scientific or medical laboratories as a service; provision of software to customers in a Software as a Service model; Technical research; Engineering services; Geological surveys; Surveying; Land surveying; Geological research; Computer programming; Computer software design; Consultancy in the field of computers; Maintenance of computer software; Installation of computer software; Updating of computer software; Technical consultancy relating to the use of scientific, optical and electronic apparatus and devices; Technical consultancy relating to the use of scientific, optical and electronic apparatus and devices, in particular for scientific and medical facilities.

Goods & Services

Scientific apparatus and instruments for scientific research in laboratories; Scientific apparatus and equipment, namely, scientific laboratory workstations and associated computer software used for protein, nucleic acid or immunoassay analysis in the fields of in-vitro diagnostics and biomedical diagnosis; computer operated automation systems comprised of computer hardware and operating software for laboratory instruments; laboratory instruments for specimen preparation; automated immunostainers for laboratory use; laboratory equipment for use in specimen preparation, namely, tissue processors; haematology slide makers and stainers for placing a barrier on a slide for use in scientific research; clinical chemistry instruments for laboratory use, namely, Clinical chemistry analyzers; random access clinical chemistry analysers for the analysis of biological samples for scientific research purposes; Laboratory instruments, namely, immunoassay clinical analysers; histopathology instruments, tissue processors and haematology instruments used in scientific research for processing biological samples; Scientific laboratory apparatus for histology and cytology, namely Coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines, Automatic colouring machines, Staining machines with immunological responses; tissue processors for processing biological samples for laboratory use; multiwell plates, for use in the following fields: chemical analytical services, Laboratory research services; Cryostats for laboratory use; Cryomacrotomes, For laboratory use; automatic slide scanners; laboratory equipment and supplies for collecting, preparing, holding and filing of histological and cytological specimens for microscopic, magnetic resonance, tomosynthesis, ultra-sound or x-ray examination, namely, sample containers, specimen containers, sample cassettes, biopsy cassettes; label printer for printing labels for sample cassettes and biopsy cassettes; barcode reader for reading the printed labels on sample cassettes and biopsy cassettes; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples; Microtomes, Microtome blades, for use in the following fields: Histology laboratories, Not for medical purposes; ultramicrotomes and ultramicrome blades, diamond knives, glass knives, glass breaker for preparing glass knives for laboratory use; Physical and optical apparatus and instruments; Enlargers; electronic and electrical apparatus and instruments for storing, transmitting and processing date; precision scientific and optical apparatus and instruments, Projection apparatus; Microscopes; Microphotographic apparatus; Digital microscopes; Microscopes for operations; Micro projection apparatus and micromanipulators, Microtomes, Microscopic and microtomic hot or cold object tables (laboratory apparatus); Microscopes for medical use; Automated microscopes; Optical light microscopes; Laser scanning microscopes; Measuring microscopes; Photomicroscopes; Confocal laser microscopes; TIRF microscopes; Routine microscopes; Life science research microscopes; Clinical microscopes; microscope platforms; Digital microscopes, Especially, Digital microscopes for routine inspection work; Digital microscopes, Especially, Digital microscopes for quality control; Digital microscopes for routine inspection processes for research and development work; microscope systems; Microscope systems for digital inspection, observation and measurement; Laser scanning microscopy; Laser microdissection apparatus; Eyepieces for projection, microscopes and measuring technology; Macroscopes, photo macroscopes; Microtomes in particularly ultramicrotomes, cryomicrotomes, Electronic microlithography apparatus and instruments; Surgical microscopes; parts and components of surgical microscopes; multispectral fluorescence imaging systems; parts and components of multispectral fluorescence imaging systems; optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; systems and apparatuses for performing multispectral fluorescence microscopy and associated software; systems and apparatuses for performing 3D microscopy or multispectral fluorescence imaging and associated software; Medical devices and instruments, Namely microscopes and Microscopes for operations; Digital image capture and data processing apparatus for use in the medical sector; Microscopes for operations; Operating microscopes for use in surgery; Operating microscopes for use in minimally invasive surgery and microsurgery; Operating microscopes for use in neurosurgery; Operating microscopes for use in ophthalmology; Operating microscopes for use in the ENT region; Operating microscopes for use in dentistry; parts and fittings for all such apparatus and instruments; Tissue cutting tools and micro and macro tissue grossing stations for laboratory use; fume hoods for specimen preparation for laboratory use; microscopic slides and cover glass; cover tiles for immunostainers; specimen embedding cassettes; specimen embedding stations for laboratory use; slide and specimen cassette electric printers; Image analysis apparatus, namely, Reading and writing devices for codes of multiwell plates, cassettes, slides, sample carriers, namely, barcode scanners, storing and transporting devices, namely Blank hard drives for computers; software for tracking the location of histological and cytological specimens; software operating for histological and cytological scientific and diagnostic apparatus and laboratory equipment; computer software for digitizing microscope slides for viewing, integration with other data, management, and analysis, all in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; automated digital scanning system comprised of computer hardware and operating software integrating optical microscopy, motorized sample positioning, digital image capture, data processing, manipulation and display for use in scanning and digitizing microscope samples in research and clinical environments; digital slide information management software for digitizing entire glass microscope slides into diagnostic quality images displayed in context with reports, case histories and other associated documents, cross-linked and concurrently viewable for use in the fields of virtual microscopy, digital pathology, digital hematology and medical information technology; Precision optical components; Scientific, optical and measuring apparatus and instruments; Parts for all the aforesaid goods, in particular exchangeable components and assemblies; Accessories, Namely bellows adjustment apparatus, Adapters, angle finders, protective lids, daylight boxes, Magazines, Cassettes, micro and macro-projection attachments, Lighting devices for microscopes; software for use with microscopes; Analysis software for the use with microscopes without external apparatus; Digital microscope cameras with software for microscopes; Software operating systems for digital microscopes; Software for use with the aforesaid hardware, Especially, Operating software, image analysis software, image storage software, Software for operational processes in and between scientific and medical devices, Software for documentation and analysis in life science, clinical and industrial applications; downloadable software for processing digital images; Downloadable sample recognition software for identifying and extracting interesting characteristics from digital images; Downloadable sample recognition software for processing digital images; Computer software for mobile data processing apparatus; Computer software for mobile data processing apparatus for remote data connection to a microscope or operating microscope or microscopic camera or operating microscopic camera; computer software for connection to a mobile data processing apparatus with a camera for image capture, adaptation, alteration, archiving or sharing live images or recorded images; Computer software for providing live images from a variety of image sources; Computer software for using a data processing apparatus as image source; software for use with microscopes, surgical microscopes, multispectral fluorescence imaging systems and with optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; Computer software for data and image capture and processing for use with microscopes and operating microscopes; Computer software for microscopes and operating microscopes. Surgical, medical, dental and veterinary apparatus and instruments; Medical apparatus, in particular, histopathology instruments, tissue processors and haematology instruments for clinical purposes, namely tissue staining instruments for staining; Medical diagnostic apparatus and instruments, in particular, diagnostic medical apparatus for performing Immuno-histochemistry and In situ-hybridisation staining reactions, and histological and pathological staining; Medical apparatus for DNS in situ hybridisation probes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covers; medical instruments, needles, probes, and devices for the purpose of tissue biopsy or tissue removal from glands and/or organs in the human body; Surgical devices, Namely vacuums for breast biopsies; Namely automated slide stainers for use in medical laboratories; Multiwell plates, for use in the following fields: medical research; biopsy site markers; x-ray, magnetic resonance, tomosynthesis, ultrasound or microscope-based devices for examining tissue samples, namely, sample preparation device for medical diagnostic uses; Ophthalmological apparatus and instruments, especially refractometers, Tonometers, Keratometers, projection apparatus for medical use; Ophthalmological apparatus and devices, in particular refractometers, tonometers, keratometers, drawing projectors; systems consisting of the above apparatus and instruments. Maintenance and repair of scientific apparatus and equipment; maintenance and repair of pathology and clinical laboratory apparatus; maintenance and repair of computer operated automation systems for laboratory instruments; maintenance and repair of precision engineering, optical, electro-acoustic and ophthalmological apparatus and systems; Conducting of maintenance and repair of the aforesaid goods for the aforesaid applications; maintenance and repair of precision, optical, photographic, photogrammetric, physics, measuring, electrotechnical, electronic, optronic, electro-acoustic and ophthalmologic apparatus, instruments and systems. Arranging of multimedia presentations, training courses and lectures, publication of application technology and product-related information and scientific data; Practical training [demonstration]; Conducting workshops [training]. Science and technology services, Scientific and technological research, drafting services, Development, In relation to the following goods: Computer hardware, Computer software; drafting services, Development, In relation to the following goods: Software, Especially, Software for [digital] microscopes; Development of software for microscope analysis tasks; Development of software for digital image analysis systems for microscopic examination and analysis; Development of data processing programmes for scientific, optical and electronic apparatus and devices; Design of data processing programs; Scientific and technological services, namely, research and design in the field of testing, analyzing, examining or storing biological samples, medical samples, and cell samples; industrial analysis and research services namely, scientific research services for medical purposes, laboratory biological research, clinical biological research, biological research and research relating to the testing of biological samples, medical samples, and cell samples; creation of computer programs for the data processing of scientific, optical and electronic apparatuses and devices; creation of computer programs for use in providing data processing for scientific, diagnostic, research or laboratory purposes for use in microtomes, ultramicrotomes, cryomicrotomes, cryostats, macrotomes, cryomacrotomes, telepathology devices, automatic slide scanners; Development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, coverslipping machines for slides, tissue infiltration apparatus, tissue embedding machines; Development of computer programs for use in data processing for scientific, diagnostic, research or laboratory purposes for use in laboratory devices for histology and cytology, namely, staining machines, staining machines with immunological responses, contrasting machines, glass knife breakers, high-pressure freezing devices for microscopic sample preparation, and sample carriers for microscopic preparations; scientific consultation, namely, technical advice for scientific and medical institutions with respect to the application of scientific, diagnostic, research and laboratory optical and electronic apparatuses and devices, not to include medical consultations; maintenance and repair of scientific devices, namely, computer operating software for image analysis and image storage devices; maintenance and repair of computer operating software for image analysis and image storage devices; operation of scientific or medical laboratories as a service; provision of software to customers in a Software as a Service model; Technical research; Engineering services; Geological surveys; Surveying; Land surveying; Geological research; Computer programming; Computer software design; Consultancy in the field of computers; Maintenance of computer software; Installation of computer software; Updating of computer software; Technical consultancy relating to the use of scientific, optical and electronic apparatus and devices; Technical consultancy relating to the use of scientific, optical and electronic apparatus and devices, in particular for scientific and medical facilities.

Abstract

A high pressure freezing cartridge (300, 400, 500) for use in vitrification of a biological sample (10) is provided, the cartridge (300, 400, 500) being adapted to fixedly hold a sample chamber (216, 218, 220) at a sample chamber position (320, 420, 520) in the cartridge (300, 400, 500), a refrigerant channel arrangement comprising at least one refrigerant channel (208, 308, 408, 462, 464, 466, 468, 508, 562, 564, 566, 569) being provided in the cartridge (300, 400, 500) and extending from a surface of the cartridge (300, 400, 500) to the sample chamber position, and the cartridge (300, 400, 500) comprising a baffle structure (350, 450, 550, 571) at a baffle position being adapted to interact with a refrigerant stream in the refrigerant channel arrangement before the refrigerant of the refrigerant stream reaches the sample chamber position in the cartridge (300, 400, 500). A corresponding method in which the high pressure freezing cartridge (300, 400, 500) is used is also part of the present disclosure.

IPC Classes  ?

• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation

Abstract

The invention relates to a control system (130) for an imaging system (100) for real-time imaging of a subject (190), using optical coherence tomography and video imaging, the control system (130) being configured to: control the imaging system (100) to determine, from a video image (152) of the subject (190), a position and/or an orientation (152) of a tissue of interest (192) in the subject (190), control the imaging system (100) to perform a scan of the subject (190) by means of optical coherence tomography, wherein a position and/or an orientation (144) of the scan is determined based on the position and/or orientation (154) of the tissue of interest (192) in the video image (152), and provide an optical coherence tomography image (142) of the subject (190), including the tissue of interest (192), based on the scan, to an imaging system (100) and a corresponding method.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/14 - Arrangements specially adapted for eye photography

Goods & Services

Smartphones; smartphones in the form of wristwatches or other body-worn devices [wearables], in particular with camera function; computers; mobile computers; tablet computers; cameras for and in the aforementioned products; software, application software [apps] for and in the aforementioned products.

Goods & Services

Smartphones; smartphones in the form of wristwatches or other body-worn devices [wearables], in particular with camera function; computers; mobile computers; tablet computers; cameras for and in the aforementioned products; software, application software [apps] for and in the aforementioned products.

Abstract

A method is proposed for generating a series of ultra-thin sections of a microscopic sample (10), wherein the sections (11) are detached from the sample (10) using an ultramicrotome (100) and wherein the sections (11), which are detached from the sample (10) are caused to float on a liquid surface and are thereafter transferred onto a solid carrier element (20). For at least for some of the sections (11) detached from the sample (10) a position and an orientation on the solid carrier element (20) are determined by monitoring the placement of these sections (11) onto the solid carrier element (20) using a monitoring system (400) comprising a camera (410), obtaining monitoring data. A method (2000) for the three-dimensional reconstruction of a microscopic sample (10), a microtome system and a computer program are also part of the present invention.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
• G01N 1/36 - Embedding or analogous mounting of samples

Goods & Services

Smartphones; smartwatches and other body-worn devices, namely, wearable smart glasses with camera function; computers; mobile computers; tablet computers; cameras for and in the aforementioned products; downloadable and recorded software to perform camera functions and downloadable application software for mobile phones, smart watches and smart glasses, namely, software to perform camera functions for and in the aforementioned products

Goods & Services

Smartphones; smartwatches and other body-worn devices, namely, wearable smart glasses with camera function; computers; mobile computers; tablet computers; cameras for and in the aforementioned products; downloadable and recorded software to perform camera functions and downloadable application software for mobile phones, smart watches and smart glasses, namely, software to perform camera functions for and in the aforementioned products

Abstract

A computerized model compatibility regulation method for imaging applications first performs a target domain B application by computing means using at least one image X and target domain B image analytics to generate a target domain B application output for X. The method then applies a reference domain A application by computing means to generate reference domain A application output for X. The method further performs a compatibility assessment to generate at least one compatibility result for X. In addition, the method checks the compatibility result for X and if the check output is incompatible, the method performs online correction to generate a corrected application output for X.

IPC Classes  ?

• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/08 - Learning methods

Goods & Services

Microscopes; Microscopes with digital enhanced functionality, namely, microscopes with downloadable virtual and augmented reality software for providing overlay functions; cameras, head-up displays and monitors for use in microscopes and surgical microscopes; recorded or downloadable computer software for capturing and processing data and images for use with microscopes and microscopes for operations; downloadable or recorded computer software for performing 3D microscopy or multispectral fluorescence imaging and to operate microscopes and digital cameras Surgical imaging devices, namely, multispectral fluorescence imaging systems comprised primarily of medical imaging systems, namely medical image processors, surgical microscopes, surgical microscopes for use in minimally invasive surgery and microsurgery, surgical microscopes for use in neurosurgery, spinal surgery, cancer surgery and related hardware, namely, medical imaging processors and surgical microscopes and related recorded software sold as a unit; surgical microscopic imaging systems comprised of surgical microscopes, multispectral fluorescence imaging systems comprised primarily of medical imaging systems, namely medical imaging devices and surgical microscopes and medical image processors, surgical microscopes, surgical microscopes for use in minimally invasive surgery and microsurgery, surgical microscopes for use in neurosurgery, spinal surgery, cancer surgery and related hardware, namely medical image processors and surgical microscopes and related recorded software sold as a unit; ophthalmological apparatus and instruments, namely, Operating microscopes for use in surgery; Operating microscopes with digital enhanced functionality, namely, Virtual and Augmented reality overlay functions for viewing tissue and bodily structures; Operating microscopes for use in ophthalmology, multispectral fluorescence imaging systems comprised primarily of medical imaging systems, namely, namely medical image processors and surgical microscopes Design and development of computer hardware and software for microscopes and surgical microscopes; scientific and technological services, namely, design and development of computer hardware and software Consulting and information services relating to medical products; medical services; medical equipment rental

Goods & Services

Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images; electronic apparatus for recording and displaying images; apparatus for enlargement, projection and reproduction; binoculars; electronic flashes; objectives; viewfinders; rangefinders; spotting scopes; diaphragms; filters for use with the aforementioned apparatus and instruments; optical filters; camera filters; photographic filters; filters [photography]; lens filters for cameras; light filters for cameras; filters for optical devices; filters for use in photography; tripods for cameras; optical lenses; spectacles [eyeglasses and goggles]; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with or without integrated cameras; spectacle lenses; monocles; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; holders for parts of the aforementioned apparatus and instruments, cases and housing for the aforementioned goods as well as parts of the aforementioned apparatus and instruments; camera cases; camera cases [made of leather]; target sights [except telescopic sights], reflex sights, red dot sights for the use with the aforementioned apparatus and instruments; firearm sights (telescopic); telescopic sights for firearms; sights for firearms [telescopic]. Photography drones; camera drones. Sighting devices [non optical] for firearms, except telescopic sights; open sights for firearms. Gemstones, pearls and precious metals, and imitations thereof; articles of jewellery; ornaments (jewellery); ornaments, made of or coated with precious or semi-precious metals or stones, or imitations thereof; chronometers, in particular watches; other articles of precious metals and precious stones, and imitations thereof, namely statues and figurines, ornaments [jewelry]; imitation jewelry ornaments; ornaments for the goods described in this class; coins and tokens, works of art of precious metal, key rings [trinkets or fobs]; jewellery boxes and watch boxes; parts and accessories for all the aforesaid goods included in this class. Leather and imitations of leather; animal skins and hides; luggage and carrying bags; leather bags; imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals. Headgear; clothing; footwear; parts for all the aforesaid goods included in this class. Maintenance and repair of optical and photographic apparatus as well as photography drones. Education services; art gallery services; organisation of conferences, exhibitions and fairs.

Goods & Services

Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images; electronic apparatus for recording and displaying images; apparatus for enlargement, projection and reproduction; binoculars; electronic flashes; objectives; viewfinders; rangefinders; spotting scopes; diaphragms; filters for use with the aforementioned apparatus and instruments; optical filters; camera filters; photographic filters; filters [photography]; lens filters for cameras; light filters for cameras; filters for optical devices; filters for use in photography; tripods for cameras; optical lenses; spectacles [eyeglasses and goggles]; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with or without integrated cameras; spectacle lenses; monocles; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; holders for parts of the aforementioned apparatus and instruments, cases and housing for the aforementioned goods as well as parts of the aforementioned apparatus and instruments; camera cases; camera cases [made of leather]; target sights [except telescopic sights], reflex sights, red dot sights for the use with the aforementioned apparatus and instruments; firearm sights (telescopic); telescopic sights for firearms; sights for firearms [telescopic]. Photography drones; camera drones. Sighting devices [non optical] for firearms, except telescopic sights; open sights for firearms. Gemstones, pearls and precious metals, and imitations thereof; articles of jewellery; ornaments (jewellery); ornaments, made of or coated with precious or semi-precious metals or stones, or imitations thereof; chronometers, in particular watches; other articles of precious metals and precious stones, and imitations thereof, namely statues and figurines, ornaments [jewelry]; imitation jewelry ornaments; ornaments for the goods described in this class; coins and tokens, works of art of precious metal, key rings [trinkets or fobs]; jewellery boxes and watch boxes; parts and accessories for all the aforesaid goods included in this class. Leather and imitations of leather; animal skins and hides; luggage and carrying bags; leather bags; imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals. Headgear; clothing; footwear; parts for all the aforesaid goods included in this class. Maintenance and repair of optical and photographic apparatus as well as photography drones. Education services; art gallery services; organisation of conferences, exhibitions and fairs.

Goods & Services

Microscopes; digital microscopes; parts and components of microscopes; surgical microscopes; parts and components of surgical microscopes; multispectral fluorescence imaging systems; parts and components of multispectral fluorescence imaging systems; optical systems for microscopes surgical microscopes and multispectral fluorescence imaging systems; digital systems for microscopes; 3D-systems for microscopes; Virtual reality systems for microscopes; Head-mounted displays (HMD) for the use with microscopes; Head-mounted augmented reality displays for the use with microscopes; Head-up displays for the use with microscopes; Virtual reality goggles for the use with microscopes; virtual reality glasses for the use with microscopes; Virtual reality software for the use within microscopy; Virtual and augmented reality software (for the use with microscopes); virtual reality software for simulation; Virtual reality software for microscopy; 3D glasses, 3D eye glasses, 3D spectacles for the use with microscopes: Augmented reality software for simulation; Augmented reality software for the use with microscopes; software for use with surgical microscopes; multispectral fluorescence imaging systems and optical systems for microscopes; systems and apparatuses for performing multispectral fluorescence microscopy and associated software; systems and apparatuses for performing 3D microscopy or multispectral fluorescence imaging and associated software; software and digital imaging solutions for a surgical microscope purpose; digital microscope platforms and software. Surgical imaging devices; surgical devices comprising multispectral fluorescence imaging systems. Design and development of computer hardware and software for surgical microscopes; Rendering of computer graphics (digital imaging services); Design and development of virtual reality software for the use with microscopes; Software design for the use with 3D microscopy.

Abstract

A system for identifying presence of a conjugate in an image comprising one or more processors and one or more storage devices is provided. The system is configured to acquire spectral data associated with a sample to be imaged. Dispersion coefficients are optimized for acquired spectral data. A corrective phase function is calculated using the optimized dispersion coefficients. A negative corrective phase function is applied to a signal to provide a resulting image. It is determined if the resulting image has degraded signal strength or an enhanced signal strength relative to an original image. A reference arm shift is calculated if it is determined that the resulting image has enhanced signal strength. A position of a reference arm of the system is adjusted based on the calculated reference arm shift to move a conjugate image out of view.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/13 - Ophthalmic microscopes

Abstract

A system for optimizing optics is provided. The system is configured to calibrate a position of a reference arm of an interferometric imaging system such that an image of a sample is visible when the sample is positioned at a working distance of an objective lens to provide an initial calibrated position. An image is obtained using the initial calibrated position. Image quality of the obtained image is assessed to determine if the obtained image is a valid image. A path length of the reference arm is adjusted if it is determined that the obtained image is not a valid image. A difference between the calibrated position of the reference arm and the adjusted position of the reference arm is calculated. System elements are adjusted based on the calculated difference such that the sample is visible when the sample is positioned at the working distance at the adjusted position.

IPC Classes  ?

• G02B 21/00 - Microscopes
• A61B 3/00 - Apparatus for testing the eyesInstruments for examining the eyes
• G01B 9/02 - Interferometers
• G02B 21/24 - Base structure
• G02B 7/38 - Systems for automatic generation of focusing signals using image sharpness techniques measured at different points on the optical axis

Goods & Services

Sights for firearms, except telescopic sights; open sights for use on firearms Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images, namely, cameras for photography, video cameras and microscopes; electronic apparatus for recording and displaying images, namely, camcorders and video cameras; binoculars; electronic flashes; microscope objectives; viewfinders; laser rangefinders; spotting scopes; filters for use with the aforementioned apparatus and instruments, namely, cameras for photography, video cameras, microscopes, viewfinders, binoculars, spotting scopes and rangefinders; optical filters; camera filters; photographic filters; filters for use in photography, namely, photographic filters; lens filters for cameras; UV light filters for digital cameras; filters for optical devices; tripods for cameras; optical lenses; spectacles; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with or without integrated cameras; spectacle lenses; monocles; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; cases and housing for the aforementioned goods as well as replacement parts of the aforementioned apparatus and instruments; camera cases; camera cases made of leather; target sights, namely, optical lens sights, telescopic lens sights, rifles scopes, handgun scopes, scopes for crossbows for archery, telescopic bow sights, reflex sights for firearms, optical red dot sights; firearm telescopic sights; telescopic sights for firearms Photography drones; camera drones watches; presentation boxes for watches Leather and imitations of leather; animal skins and hides; luggage; leather bags; imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals Headwear, namely, hats and caps; clothing, namely, shirts, trousers, jackets, underwear and socks; footwear Maintenance and repair of optical and photographic apparatus as well as photography drones Education services, namely, conducting classes in the field of photography, videography and microscopy; Entertainment services, namely, live musical performances, provided by art galleries; organisation of educational conferences in the field of photography, videography and microscopy; exhibitions for cultural or educational purposes and conducting fairs for entertainment purposes

Goods & Services

Sights for firearms, except telescopic sights; open sights for use on firearms Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images, namely, cameras for photography, video cameras and microscopes; electronic apparatus for recording and displaying images, namely, camcorders and video cameras; binoculars; electronic flashes; microscope objectives; viewfinders; laser rangefinders; spotting scopes; filters for use with the aforementioned apparatus and instruments, namely, cameras for photography, video cameras, microscopes, viewfinders, binoculars, spotting scopes and rangefinders; optical filters; camera filters; photographic filters; filters for use in photography, namely, photographic filters; lens filters for cameras; UV light filters for digital cameras; filters for optical devices; tripods for cameras; optical lenses; spectacles; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with or without integrated cameras; spectacle lenses; monocles; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; cases and housing for the aforementioned goods as well as replacement parts of the aforementioned apparatus and instruments; camera cases; camera cases made of leather; target sights, namely, optical lens sights, telescopic lens sights, rifles scopes, handgun scopes, scopes for crossbows for archery, telescopic bow sights, reflex sights for firearms, optical red dot sights; firearm telescopic sights; telescopic sights for firearms Photography drones; camera drones watches; presentation boxes for watches Leather and imitations of leather; animal skins and hides; luggage; leather bags; imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals Headwear, namely, hats and caps; clothing, namely, shirts, trousers, jackets, underwear and socks; footwear Maintenance and repair of optical and photographic apparatus as well as photography drones Education services, namely, conducting classes in the field of photography, videography and microscopy; Entertainment services, namely, live musical performances, provided by art galleries; organisation of educational conferences in the field of photography, videography and microscopy, exhibitions for cultural or educational purposes and conducting fairs for entertainment purposes

Goods & Services

Scientific apparatus and instruments; Microscopes; Microscopes for medical use; parts and components of microscopes; Surgical microscopes; parts and components of surgical microscopes; Microscopes for operations; Surgical microscopes, For eye operations; Medical devices and instruments, Namely microscopes and Microscopes for operations; Operating microscopes for use in surgery; Microscopes for operations, For use in eye surgery; Microscopes and operation microscopes with integrated OCT (optical coherence tomography) functions; Optical systems for microscopes; parts and fittings for all such apparatus and instruments; Microscope imaging system; microscopes accessories; Apparatus and systems For 3D microscopy and the accompanying software; Cameras [photography], Head-up display devices and Monitors For use in microscopes or operation microscopes; software for use with microscopes; Computer software for data and image capture and processing for use with microscopes and operating microscopes; Computer software for microscopes and operating microscopes. Surgical imaging devices; Surgical microscope imaging system; surgical microscope accessory; Ophthalmological apparatus and instruments. Design and development of computer hardware and software for surgical microscopes; Scientific and technological services, and design and development of computer hardware and software. Consultancy and information services relating to medical products; Medical services; Medical equipment rental; Services for the provision of medical facilities.

Abstract

Provided are an imaging unit 104 that uses a light emitted from a second beam splitter 202 of a microscope 2 that can use an exciting light and an observation light, which is a light including a wavelength other than that of the exciting light, as a light source by switching there between and is provided with the second beam splitter 202 to image images of the same observation region of the microscope 2 in situations where the exciting light and the observation light are used as the light source and an output unit 106 that overlaps, synthesizes, and outputs the images imaged by the imaging unit 104 respectively using the exciting light and the observation light as the light source.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/28 - Investigating the spectrum
• G02B 27/10 - Beam splitting or combining systems
• G01N 21/64 - FluorescencePhosphorescence
• G01J 3/00 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours

Goods & Services

Protective and safety equipment, namely, personal protective equipment in the nature of protective work gloves and safety goggles; protective face masks for the prevention of accident or injury; non-medical respiratory masks, namely, protective industrial respiratory masks and respiratory masks for the prevention of accident or injury; non-medical respiratory mask filters; respirators, other than for artificial respiration, namely, respirators for the prevention of accident or injury and protective industrial respirators; anti-pollution masks for respiratory protection; face shields, other than for medical purposes, namely, protective industrial face shields, bullet-resistant face shields, workmen's protective face-shields, and face shields for protection against fire Mouth masks for medical purposes, namely, surgical masks and anesthesia masks; protective mouth masks for medical use, namely, personal protective equipment in the nature of masks for use by medical personnel and sanitary masks for protection against viral infection; protective masks for use by medical personnel; medical masks, namely, oxygen masks for medical use, sanitary masks for medical purposes, aerosol masks for medical use, respiratory masks for medical purposes, and sanitary masks for medical wellness purposes; high filter surgical masks; respiratory masks for medical applications; protective face masks for medical use; sanitary masks for medical use

Goods & Services

Protective and safety equipment; protective masks; respiratory masks, non-medical; respiratory mask filters [non-medical]; respirators, other than for artificial respiration; anti-pollution masks for respiratory protection; face shields, other than for medical purposes. Mouth masks for medical purposes; protective mouth masks for medical use; protective masks for use by medical personnel; medical masks; high filter surgical masks; respiratory masks for medical applications; face masks for medical use; sanitary masks for medical use.

Goods & Services

Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images; electronic apparatus for recording and displaying images; apparatus for enlargement, projection and reproduction; binoculars; electronic flashes; objectives; viewfinders; rangefinders; spotting scopes; diaphragms; filters; tripods for cameras; optical lenses; spectacles [eyeglasses and goggles]; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with our without integrated cameras; spectacle lenses; monocles; firearm sights; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; magazines for part of the aforementioned apparatus and instruments, cases and housing for the aforementioned goods as well as parts of the aforementioned apparatus and instruments; camera cases; camera cases [made of leather]; target sights [except telescopic sights], reflex sights, red dot sights for the use with the aforementioned apparatus and instruments. Photography drones; camera drones. Sighting devices [non optical] for firearms, except telescopic sights; open sights for firearms. Gemstones, pearls and precious metals, and imitations thereof; articles of jewellery; ornaments (jewellery); ornaments, made of or coated with precious or semi-precious metals or stones, or imitations thereof; chronometers, in particular watches; other articles of precious metals and precious stones, and imitations thereof, namely statues and figurines, ornaments [jewelry]; imitation jewelry ornaments; ornaments for the goods described in class 9; coins and tokens, works of art of precious metal, key rings [trinkets or fobs]; jewellery boxes and watch boxes; parts and accessories for all the aforesaid goods included in this class. Leather and imitations of leather; animal skins and hides; luggage and carrying bags; leather bags; Imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals. Headgear; clothing; footwear; parts and accessories for all the aforesaid goods included in this class. Maintenance and repair of optical and photographic apparatus as well as photography drones. Education services; Art gallery services; Organisation of conferences, exhibitions and fairs.

Goods & Services

Optical, photographic, opto-electronic, electronic, electro-optical and precision mechanics apparatus and instruments for recording and displaying images; electronic apparatus for recording and displaying images; apparatus for enlargement, projection and reproduction; binoculars; electronic flashes; objectives; viewfinders; rangefinders; spotting scopes; diaphragms; filters; tripods for cameras; optical lenses; spectacles [eyeglasses and goggles]; sunglasses; sports glasses; optical lenses for use with sunglasses; spectacle cases; spectacle frames; monocle frames; contact lenses; contact lens blanks; 3D spectacles; smartglasses with our without integrated cameras; spectacle lenses; monocles; firearm sights; optical lens sights; rifle scopes; smart phones; cameras for smart phones; tablet computers; cameras for tablet computers; film magazines for cameras; magazines for part of the aforementioned apparatus and instruments; cases and housing for the aforementioned goods as well as parts of the aforementioned apparatus and instruments; camera cases; camera cases [made of leather]; target sights [except telescopic sights], reflex sights, red dot sights for the use with the aforementioned apparatus and instruments. Photography drones; camera drones. Sighting devices [non optical] for firearms, except telescopic sights; open sights for firearms. Gemstones, pearls and precious metals, and imitations thereof; articles of jewellery; ornaments (jewellery); ornaments, made of or coated with precious or semi-precious metals or stones, or imitations thereof; chronometers, in particular watches; other articles of precious metals and precious stones, and imitations thereof, namely statues and figurines, ornaments [jewelry]; imitation jewelry ornaments; ornaments for the goods described in class 9; coins and tokens, works of art of precious metal, key rings [trinkets or fobs]; jewellery boxes and watch boxes; parts and accessories for all the aforesaid goods included in this class. Leather and imitations of leather; animal skins and hides; luggage and carrying bags; leather bags; Imitation leather bags; umbrellas and parasols; walking sticks; whips, harness and saddlery; collars, leashes and clothing for animals. Headgear; clothing; footwear; parts and accessories for all the aforesaid goods included in this class. Maintenance and repair of optical and photographic apparatus as well as photography drones. Education services; Art gallery services; Organisation of conferences, exhibitions and fairs.

Abstract

Systems for determining an apex of curvature In an image, obtained from, a sample are provided. The systems include -an imaging system configured to obtain a plurality of scans of a sample using a radial pattern; and a processor associated with the imaging system. The processor is configured to segment and curve fit each of the plurality of scans to a surface of the sample; determine an apex.for each curve associated with each of the plurality of scans; determine a true apex, among all determined apexes using a derivative of least value; calculate an XY offset based on the determined true apex; map the true apex to an origin where X and Y are equal to zero; and adjust the coordinates associated with remaining apexes not determined to be the true apex based on the calculated offset.

IPC Classes  ?

• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• A61B 3/107 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for determining the shape or measuring the curvature of the cornea

Abstract

The present invention relates to a method and a system for imaging at least one part of a sample using two microscopic imaging methods, wherein a surface (11) of the sample (10) is imaged using a first microscopic imaging method, wherein a replica (25) of the surface (11) to be imaged by the first microscopic imaging method is produced, and this replica (25) is simultaneously imaged using a second microscopic imaging method, and wherein the images generated by the first and the second microscopic imaging method are superposed in a manner that is true to scale.

IPC Classes  ?

• G02B 21/24 - Base structure
• B22D 23/00 - Casting processes not provided for in groups
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• H01J 37/22 - Optical or photographic arrangements associated with the tube

Abstract

A method is proposed for generating a series of sections of a microscopic sample (10), in which the sections are detached from the sample (10) by means of a blade (21), collected, and placed onto a transfer device. A sequence in which the sections are detached from the sample is detected; detachment of the sections from the sample (10) and/or collection of the sections and/or placement of the sections onto the transfer device is monitored by means of one or several observation cameras, accompanied by the acquisition of moving-image data; the sections are tracked in the moving-image data; and positions of the sections on the transfer device are correlated, on the basis of the tracking in the moving-image data, with the sequence in which they were detached from the sample. Also subjects of the present invention are a method for three-dimensional reconstruction of a microscope sample (10), in which sections of the sample (10) are microscopically investigated accompanied by acquisition of section image data and in which the section image data are assembled into a volume image; and a corresponding microtome system (100) having a microtome (110) and a data acquisition and evaluation unit (120), and having one or several observation cameras (30).

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G06T 7/00 - Image analysis
• G06T 7/292 - Multi-camera tracking
• G01N 1/06 - Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
• G06T 11/00 - 2D [Two Dimensional] image generation
• G06T 7/55 - Depth or shape recovery from multiple images

Abstract

Spectrometer systems are provided including a detector array (320); an imaging lens assembly (327) coupled to the detector array, the imaging lens assembly including a first element of positive optical power (336) followed by a second element of negative optical power (333) and a positive optical power element (325) split into two opposing identical singlets; a dispersive element (345) coupled to the imaging lens assembly; and a fixed focus collimator (353) assembly coupled to the dispersive element.

IPC Classes  ?

• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• G01B 9/02 - Interferometers
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/18 - Generating the spectrumMonochromators using diffraction elements, e.g. grating
• G01J 3/28 - Investigating the spectrum
• G01J 3/45 - Interferometric spectrometry
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The invention relates to a syringe device (1) comprising - a body (100), - a cylindrical retainer tube (10) coaxially comprising a wire (20) relatively moveable with respect to the retainer tube (10), - a handle means (40) configured for causing the relative movement of the retainer tube (10) and the wire (20), the retainer tube (10) and the wire (20) being separable together from the body (100).

IPC Classes  ?

• B01L 3/02 - BurettesPipettes
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12M 1/26 - Inoculator or sampler
• A61B 10/02 - Instruments for taking cell samples or for biopsy

Abstract

A modular specimen holder (10′) for high pressure freezing and/or X-ray crystallography of a specimen has a specimen holding element (100′) and an extension element (200′) connectable with and separable from each other; the specimen holding element (100′) including a tubule (120′) adapted to hold the specimen and a base element (110′) adapted to hold the tubule (120′), wherein a distance from a bottom of the base element (110′) to a top of the tubule (120′) is a first distance (d1); the extension element (200′) being connectable with the base element (110′), wherein, when the extension element (200′) and the base element (110′) are connected with each other, a second distance (d2) from a bottom of the extension element (200′) to the top of the tubule (120′) is larger than the first distance (d1).

IPC Classes  ?

• G01N 23/20 - Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using diffraction of the radiation by the materials, e.g. for investigating crystal structureInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materialsInvestigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups , or by using reflection of the radiation by the materials
• G01N 23/20033 - Sample holders or supports therefor provided with temperature control or heating means
• G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
• G01N 23/20025 - Sample holders or supports therefor
• G01N 23/20041 - Sample holders or supports therefor for high pressure testing, e.g. anvil cells

Goods & Services

Chemicals for use in industry and science; chemical reagents for non-medical purposes; diagnostic reagents and preparations, except for medical or veterinary use; diagnostic preparations used in science; chemical reagents and diagnostic preparations for use in research laboratories and for use in industry. Pharmaceutical and veterinary preparations, namely antibodies or nucleic acid probes, for the diagnosis of cancer; reagents for medical and diagnostic purposes; diagnostic preparations for medical and veterinary preparations; reagents containing primary antibodies for medical use; chemical reagents and diagnostic preparations for medical and veterinary purposes; medical diagnostic reagents; clinical medical reagents; chemical reagents for medical or veterinary purposes, namely reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes for medical purposes; epitope retrieval solutions for medical purposes; enzymes and enzyme preparations for medical and diagnostic purposes; histological dye and stain solutions for medical purposes; dewaxing and wash buffers used with the aforementioned preparations; diagnostic preparations for clinical or medical laboratory use. Lenses, namely eyeglass lenses, contact lenses, and spectacle lenses; eyeglasses; eyeglass frames; diagnostic apparatus and instruments, not for medical purposes, namely scientific laboratory workstations and associated computer software used for protein, nucleic acid or immunoassay analysis in the fields of in-vitro diagnostics and biomedical diagnosis; diagnostic apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or scientific use; diagnostic or scientific apparatus for detection of tissue and/or cell based samples not for medical purposes; recorded and downloadable software for identifying and diagnosing cancer and other diseases and processing digital images; analysis apparatus for laboratory use for analyzing the results of tissues and cell based samples obtained through operation of tissue and cell sample staining apparatus; measuring apparatus used to identify and/or diagnose cancer and other diseases, not for medical use; diagnostic testing apparatus incorporating chemical reagents not for medical use for testing using antibodies or nucleic acid probes; authentication indicator in a diagnostic apparatus and instrument, not for medical purposes, namely a system comprising one or more sensors capable of recognizing one or more features on an exchangeable reagent kit, and giving a visual indication in response to the recognition of such feature (s) for authenticating dedicated consumables, such as reagent kits or replacement parts; microscopes and microscopes for operations and antibodies and in situ hybridisation probes. Diagnostic apparatus and instruments for medical use namely diagnostic medical apparatus for performing immuno-histochemistry and in situ-hybridisation staining reactions, and histological and pathological staining; diagnostic apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or medical use; diagnostic apparatus for detection of tissue and/or cell based samples, all for medical purposes; medical analysis and medical measuring apparatus, including, medical diagnostic instruments for the analysis of body fluids and tissue for medical diagnostic uses; apparatus for use in medical analysis namely histopathology instruments, tissue processors and haematology instruments for clinical purposes, namely, tissue staining instruments for staining; apparatus for promoting and controlling reactions on microarrays or under slide covertiles namely tissue staining devices for medical purposes; in-vitro diagnostic testing apparatus incorporating chemical reagents for medical use for testing for cancer; glass slides for surgical use in the nature of medical specimen collection devices; authentication indicator in a diagnostic apparatus and instrument for medical use, namely a system comprising one or more sensors capable of recognizing one or more features on an exchangeable reagent kit, and giving a visual indication in response to the recognition of such feature (s) for authenticating dedicated consumables, such as reagent kits or replacement parts. Medical research; scientific and technological services and research in the fields of pathology, haematology, scientific research, medical diagnostics, biological research, laboratory biological research, and clinical biological research and cancer diagnosis research; scientific and technological services, namely, including, scientific analysis and testing in the fields of in the fields of pathology, haematology, scientific research, medical diagnostics, biological research, laboratory biological research, and clinical biological research, cancer diagnosis and the detection, identification, classification and assessment of known and unknown materials; none of the foregoing services involving the collecting, analysing or reporting of market data; all the afore-mentioned for use in connection with medical analysis, diagnosis and research.

Goods & Services

Microtomes Technical consultancy for others with regard to the design of scientific and medical devices in the form of microtomes

Goods & Services

Microscopes and parts therefor Microscopes for surgical operations and parts therefor; operating microscopes for use during surgery and parts therefor; operating microscopes for use during minimally invasive surgery and microsurgery and parts therefor; operating microscopes for medical use in the ENT region and parts therefor; operating microscopes for use in dentistry and parts therefor

Goods & Services

Microscopes and parts and components of microscopes thereof; surgical microscopes, and parts and components of surgical microscopes thereof; multispectral fluorescence imaging systems for research and laboratory purposes comprised of microscopes and digital cameras and parts and components of multispectral fluorescence imaging systems thereof; optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems comprised primarily of digital cameras and microscopes; downloadable software and recorded computer media software for data processing, capturing, and recording images for use with microscopes, surgical microscopes, multispectral fluorescence imaging systems and with optical systems for microscopes, surgical microscopes and multispectral fluorescence imaging systems; systems and apparatuses for performing multispectral fluorescence microscopy, namely, microscopes, digital cameras, and downloadable and recorded computer software for processing, capturing, and recording images; systems and apparatuses for performing 3D microscopy or multispectral fluorescence imaging, namely, microscopes, digital cameras, computer software for processing, capturing, and recording images, and computer hardware Surgical imaging devices comprised of digital cameras for medical purposes; surgical devices comprising multispectral fluorescence imaging systems that consist of digital cameras for medical purposes

Abstract

The invention relates to a holding apparatus (100) for sample carriers (200) for use in cryomicroscopy, encompassing: a body having at least one sample carrier receptacle that comprises at least one sample carrier support surface against which at least one sample carrier (200) is abuttable; at least one first sample carrier holding means (121); and at least one second sample carrier holding means (131) that is configured to impinge upon the sample carrier (200) with force against the first sample carrier holding means (121); and to an arrangement having a manipulation container and such a holding apparatus (100), and to methods for introducing and withdrawing a sample carrier (200).

IPC Classes  ?

• B01L 9/00 - Supporting devicesHolding devices
• G02B 21/34 - Microscope slides, e.g. mounting specimens on microscope slides
• G02B 21/26 - StagesAdjusting means therefor
• B01L 7/00 - Heating or cooling apparatusHeat insulating devices

Goods & Services

Microscopes and parts therefor, operating microscopes and parts therefor, operating microscopes for use during surgery and parts therefor, operating microscopes for use during minimally invasive surgery and microsurgery and parts therefor, operating microscopes for ophthalmological use and parts therefor, operating microscopes for use in the ENT region and parts therefor, operating microscopes for use in dentistry and parts therefor.

Goods & Services

Microscopes; digital cameras; Digital graphic scanners; Computer software for illustrating and/or sharing images from microscopes and operating microscopes; Computer software for viewing, capturing, annotating and/or sharing images from microscopes and operating microscopes with a mobile data processing apparatus; Computer software for mobile data processing apparatus for remote data connection to a microscope or microscopic camera; Computer software for connection to a mobile data processing apparatus with a camera for image capture; Computer software for providing live images from a variety of image sources; Computer software for using a data processing apparatus as image source; Computer software for data and image capture and processing for use with microscopes and operating microscopes Medical imaging apparatus, namely, digital image capture and data processing apparatus for use in the medical sector; Microscopes for surgical operations Electronic storage services for archiving electronic images; Providing temporary use of a non-downloadable web application that enables users to share images; Providing a web site featuring technology that enables users to share images; all of said services relating to the fields of microscopy or endoscopy, surgical microscopy and endoscopy, archiving, processing or sharing of microscopic and endoscopic images

Goods & Services

Microscopes; digital cameras; Digital graphic scanners; Computer software for illustrating and/or sharing images from microscopes and operating microscopes; Computer software for viewing, capturing, annotating and/or sharing images from microscopes and operating microscopes with a mobile data processing apparatus; Computer software for mobile data processing apparatus for remote data connection to a microscope or microscopic camera; Computer software for connection to a mobile data processing apparatus with a camera for image capture; Computer software for providing live images from a variety of image sources; Computer software for using a data processing apparatus as image source; Computer software for data and image capture and processing for use with microscopes and operating microscopes Medical imaging apparatus, namely, digital image capture and data processing apparatus for use in the medical sector; Microscopes for surgical operations Electronic storage services for archiving electronic images; Providing temporary use of a non-downloadable web application that enables users to share images; Providing a web site featuring technology that enables users to share images

Goods & Services

Computer software for illustrating and/or sharing images from microscopes and operating microscopes; Computer software for viewing, capturing, annotating and/or sharing images from microscopes and operating microscopes with a mobile data processing apparatus; Computer software for mobile data processing apparatus for remote data connection to a microscope or microscopic camera; Computer software for connection to a mobile data processing apparatus with a camera for image capture; Computer software for providing live images from a variety of image sources; Computer software for using a data processing apparatus as image source; Computer software for data and image capture and processing for use with microscopes and operating microscopes Electronic storage services for archiving electronic images