Broadly speaking, the present disclosure relates to a closeable bulk fluid assembly ('CBA') which comprises a receptacle (e.g. bottle) configured to hold a reagent. The CBA may be configured to be connected to an instrument which uses the reagent (e.g. for medical purposes). In order to replenish the bottle of the CBA with a reagent, an operative scans the barcode of a reagent supply bottle. Consequently, a locking mechanism for the CBA is actuated and the front fascia will automatically open allowing access to the funnel of the bottle. The funnel can be easily opened by an operative. The operative may replenish the reagent in the bottle, but advantageously, the operative cannot remove the bottle from the CBA during a refill operation. Thus, human error is minimized because the chances of the operative mixing up the bottles are greatly reduced.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe
A61J 1/22 - Arrangements for transferring fluids, e.g. from vial to syringe with means for metering the amount of fluid
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
An apparatus for removing contaminants from a slide comprises a manifold including at least one input port and at least one output port in fluid communication with the at least one input port, the at least one output port being adapted to direct a flow of gas onto a surface of the slide such that the flow of gas removes contaminants from the slide; an aperture for receiving the slide; and an enclosure adapted to capture the contaminants removed from the slide.
B08B 5/02 - Cleaning by the force of jets, e.g. blowing-out cavities
B01D 46/10 - Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
B08B 11/02 - Devices for holding articles during cleaning
B08B 15/04 - Preventing escape of dirt or fumes from the area where they are producedCollecting or removing dirt or fumes from that area from a small area, e.g. a tool
B25J 11/00 - Manipulators not otherwise provided for
The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.
A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.
Systems and methods for hybrid virtual and chemical staining of tissue samples are disclosed. In one aspect, an image analysis apparatus includes a memory coupled to an imaging device, and a hardware processor coupled to the memory. The hardware processor is configured to receive image data from the imaging device, the image data representative of a tissue sample in a first state, and perform virtual staining of the tissue sample based on the image data to generate one or more virtual stained images of the tissue sample. The hardware processor is further configured to order chemical staining of the tissue sample in the first state, receive one or more chemically stained images, and generate a set of the one or more virtual stained images of the tissue sample from the virtual staining and the one or more chemically stained images of the tissue sample from the chemical staining.
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations including
reagents for medical and diagnostic purposes; diagnostic
preparations; reagents containing primary antibodies;
chemical reagents and diagnostic preparations for medical
and veterinary purposes; medical diagnostic reagents;
clinical medical reagents; reagents for
immuno-histochemistry detection and in situ-hybridisation
detection; in situ-hybridisation probes; epitope retrieval
solutions; enzymes and enzyme preparations for medical and
diagnostic purposes; diagnostic histological dye and stain
solutions; dewaxing and wash buffers used with the
aforementioned preparations; diagnostic preparations for
clinical or medical laboratory use. Diagnostic apparatus and instruments, not for medical
purposes, including, apparatus for staining and/or
visualization of tissue or cell based samples for diagnostic
or scientific use; apparatus for detection of tissue and/or
cell based samples not for medical purposes; recorded and
downloadable software for identifying and diagnosing cancer
and other diseases and processing digital images; analysis
apparatus for laboratory use for analyzing the results of
tissues and cell based samples obtained through operation of
tissue and cell sample staining apparatus; measuring
apparatus used to identify and/or diagnose cancer and other
diseases, not for medical use; diagnostic testing apparatus
incorporating chemical reagents not for medical use. Diagnostic apparatus and instruments for medical use
including, apparatus for staining and/or visualization of
tissue or cell based samples for diagnostic or medical use;
apparatus for detection of tissue and/or cell based samples,
all for medical purposes; medical analysis and medical
measuring apparatus, including, medical diagnostic
instruments for the analysis of body fluids and tissue for
medical diagnostic uses; medical apparatus and instruments;
apparatus for use in medical analysis; diagnostic apparatus
for medical purposes; testing apparatus for medical
purposes; diagnostic medical apparatus for promoting and
controlling reaction on microarrays or under slide
covertiles; in-vitro diagnostic testing apparatus
incorporating chemical reagents (for medical use); slides
for surgical use. Medical research; installation and integration of software,
including within existing hospital and laboratory
infrastructure; maintenance, servicing, updating and
upgrading of software; all the aforementioned for use in
connection with medical analysis, diagnosis and research.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical and veterinary preparations including reagents for medical and diagnostic purposes; diagnostic preparations; reagents containing primary antibodies; chemical reagents and diagnostic preparations for medical and veterinary purposes; medical diagnostic reagents; clinical medical reagents; reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes; epitope retrieval solutions; enzymes and enzyme preparations for medical and diagnostic purposes; diagnostic histological dye and stain solutions; dewaxing and wash buffers used with the aforementioned preparations; diagnostic preparations for clinical or medical laboratory use.
(2) Diagnostic apparatus and instruments, not for medical purposes, including, apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or scientific use; apparatus for detection of tissue and/or cell based samples not for medical purposes; recorded and downloadable software for identifying and diagnosing cancer and other diseases and processing digital images; analysis apparatus for laboratory use for analyzing the results of tissues and cell based samples obtained through operation of tissue and cell sample staining apparatus; measuring apparatus used to identify and/or diagnose cancer and other diseases, not for medical use; diagnostic testing apparatus incorporating chemical reagents not for medical use.
(3) Diagnostic apparatus and instruments for medical use including, apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or medical use; apparatus for detection of tissue and/or cell based samples, all for medical purposes; medical analysis and medical measuring apparatus, including, medical diagnostic instruments for the analysis of body fluids and tissue for medical diagnostic uses; medical apparatus and instruments; apparatus for use in medical analysis; diagnostic apparatus for medical purposes; testing apparatus for medical purposes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covertiles; in-vitro diagnostic testing apparatus incorporating chemical reagents (for medical use); slides for surgical use. (1) Medical research; installation and integration of software, including within existing hospital and laboratory infrastructure; maintenance, servicing, updating and upgrading of software; all the aforementioned for use in connection with medical analysis, diagnosis and research.
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical and veterinary preparations including reagents for medical and diagnostic purposes; diagnostic preparations; reagents containing primary antibodies; chemical reagents and diagnostic preparations for medical and veterinary purposes; medical diagnostic reagents; clinical medical reagents; reagents for immuno-histochemistry detection and in situ-hybridisation detection; in situ-hybridisation probes; epitope retrieval solutions; enzymes and enzyme preparations for medical and diagnostic purposes; diagnostic histological dye and stain solutions; dewaxing and wash buffers used with the aforementioned preparations; diagnostic preparations for clinical or medical laboratory use Diagnostic apparatus and instruments, not for medical purposes, including, apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or scientific use; apparatus for detection of tissue and/or cell based samples not for medical purposes; recorded and downloadable software for identifying and diagnosing cancer and other diseases and processing digital images; analysis apparatus for laboratory use for analyzing the results of tissues and cell based samples obtained through operation of tissue and cell sample staining apparatus; measuring apparatus used to identify and/or diagnose cancer and other diseases, not for medical use; diagnostic testing apparatus incorporating chemical reagents not for medical use Diagnostic apparatus and instruments for medical use including, apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or medical use; apparatus for detection of tissue and/or cell based samples, all for medical purposes; medical analysis and medical measuring apparatus, including, medical diagnostic instruments for the analysis of body fluids and tissue for medical diagnostic uses; medical apparatus and instruments; apparatus for use in medical analysis; diagnostic apparatus for medical purposes; testing apparatus for medical purposes; diagnostic medical apparatus for promoting and controlling reaction on microarrays or under slide covertiles; in-vitro diagnostic testing apparatus incorporating chemical reagents (for medical use); slides for surgical use Medical research; installation and integration of software, including within existing hospital and laboratory infrastructure; maintenance, servicing, updating and upgrading of software; all the aforementioned for use in connection with medical analysis, diagnosis and research
A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
An apparatus for removing contaminants from a slide comprises a manifold including at least one input port and at least one output port in fluid communication with the at least one input port, the at least one output port being adapted to direct a flow of gas onto a surface of the slide such that the flow of gas removes contaminants from the slide; an aperture for receiving the slide; and an enclosure adapted to capture the contaminants removed from the slide.
Described herein is a sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting block including a mounting surface for the substrate; a closure body configured to support a cover member, the closure body being rotatable about a first pivot axis between an open position and a closed position, such that when the substrate is placed in the assembly and the closure body is in the closed position, the cover member engages the substrate to form a reaction chamber for processing the sample; a closure body arm rotatable about the second pivot axis and engaging with the closure body so that rotation of the arm about the second pivot axis causes movement of the closure body between the open and closed positions; and a substrate retaining mechanism including: a cam, and a substrate retaining arm rotatable about the first pivot axis, the substrate retaining arm including a cam follower for sliding engagement with the cam, wherein the substrate retaining mechanism is configured so that when the closure body is closed and the cover member engages the substrate, the substrate retaining arm is clear of the substrate, as the closure body arm commences rotation to enable the closure body to rotate towards the open position, but whilst the closure body remains in a closed position, the substrate retaining arm moves into engagement with the substrate, and once the cover member is fully separated from substrate, the substrate retaining arm disengages with the substrate.
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
A method of operating a tissue processor for processing tissue samples is provided. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes the steps of conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring, by means of the at least one sensor, a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and automatically determining, based on a result of checking, whether the reagent is suitable for processing tissue samples in the tissue processor. A tissue processor for processing tissue samples is also provided. A container is also provided for storing tissue samples for processing in a tissue processor.
The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.
Blockchain-based workflow management for patient samples. In an embodiment, for each of a plurality of first devices, a request for a unique sample identifier is received from the first device, and, in response to the request, the unique sample identifier is generated and sent to the first device. Then, for each of a plurality of second devices and for each of a plurality of interactions, interaction information is received from the second device, a transaction is generated from the interaction information, and the transaction is recorded in an immutable ledger. The interaction information may comprise a unique sample identifier, a user identifier, a location, an event type, and a timestamp.
G06F 21/62 - Protecting access to data via a platform, e.g. using keys or access control rules
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
18.
SYSTEM AND METHOD FOR MATCHING OF STAINING INSTRUMENTS AND SLIDES OF HISTOLOGICAL SAMPLES
Features are disclosed for managing slides of tissue sample bocks to be mapped to staining instruments by a slide management apparatus. Each staining instrument may be associated with particular features or characteristics identifying capabilities of the staining instrument. The slide management apparatus can generate groups of slides based on the features or characteristics of each staining instrument. Each group of slides may share the same or similar characteristics. Further, the slide management apparatus can dynamically map the groups of slides to the staining instruments. The slide management apparatus may map the groups of slides based on a staining completion time. The slide management apparatus can generate a recommendation for a user based on mapping the groups of slides. For example, the recommendation may include a recommendation to place a first group of slides in a first staining instrument for staining.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.
Systems and methods for hybrid virtual and chemical staining of tissue samples are disclosed. In one aspect, an image analysis apparatus includes a memory coupled to an imaging device, and a hardware processor coupled to the memory. The hardware processor is configured to receive image data from the imaging device, the image data representative of a tissue sample in a first state, and perform virtual staining of the tissue sample based on the image data to generate one or more virtual stained images of the tissue sample. The hardware processor is further configured to order chemical staining of the tissue sample in the first state, receive one or more chemically stained images, and generate a set of the one or more virtual stained images of the tissue sample from the virtual staining and the one or more chemically stained images of the tissue sample from the chemical staining.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
21.
METHOD AND SYSTEM FOR MONITORING OPERATION OF INSTRUMENTS USING A TRANSCEIVER OVER A COMMUNICATION NETWORK
An apparatus for monitoring operation of at least one instrument using a transceiver device that communicates over a wired and/or wireless communication network. The apparatus includes a transceiver device configured to receive instrument data over the communication network. The instrument data are indicative of operation parameters of the at last one instrument. A hardware processor operationally coupled to the transceiver device is configured to process the instrument data in accordance with a customized interface. The hardware processor automatically provides a notification indicative of availability of instrument data results. A visual display is operationally coupled to the hardware processor and configured to display the instrument data results. A method of monitoring operation of at least one instrument via the wired and/or wireless communication network is also disclosed.
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
22.
Automated laboratory system resource allocation and utilization
A system and method for allocating processing resources in an automated laboratory system configured with processing units at which one or more activities are performed using one or more processing resources are provided. A scheduler component received receiving at least one order requiring the execution of one or more protocols on the automated laboratory system. The scheduler generates one or more optimisation problem instances and utilizes the optimisation problem instances to generate the schedule of activities for the automated laboratory system. The scheduler causes the implementation of the generating schedule such that the activities can be performed according to desired protocol steps.
Blockchain-based consumables management with support for offline instruments. In an embodiment, a user device scans a first machine-readable code on a consumable, scans a second machine-readable code displayed on a display of an instrument that is not communicatively connected to a blockchain network, decodes a consumable code from the first machine-readable code, decodes an instrument code from the second machine-readable code, broadcasts a transaction message, comprising the consumable code and the instrument code, to the blockchain network, receives a use code from the blockchain network, encodes the use code into a third machine-readable code, and displays the third machine-readable code, on a display of the user device, for scanning by the instrument.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
H04L 9/00 - Arrangements for secret or secure communicationsNetwork security protocols
A cassette for arranging and loading reagent containers into a staining apparatus includes a housing with a base and walls upstanding from the base to define a plurality of compartments. Each compartment is configured for receiving a reagent container. The housing includes two portions, pivotably coupled together at respective first ends thereof, and configured to pivot between an open configuration and a closed configuration. Each portion of the housing in the closed configuration is received within a corresponding one of an adjacent pair of channels located within the staining apparatus when the cassette is loaded therewithin.
A slide tray assembly for an slide input module or an slide output module of an automated treatment apparatus for treating tissue samples disposed on slides, the slide tray assembly comprising: a slide tray; and a slide tray cover adjacent to the slide tray forming one or more voids between the slide tray and the slide tray cover for receiving slides therein, wherein the slide tray cover comprises an indent at one end of the slide tray cover so that a slide handling robot of the automated treatment apparatus and an operator of the automated treatment apparatus can access the slides in the voids via the indent.
A slide output module for an automated treatment apparatus for treating tissue samples disposed on slides, the slide output module comprising: a slide output tray assembly comprising a slide output tray adjacent to a slide output cover forming one or more voids between the slide output tray and the slide output tray cover for receiving slides therein, wherein the slide output tray cover comprises a first side with a fluid inlet in communication one of the voids, and a second side configured to form a hydration chamber with a slide in said one of the voids to maintain hydration of the slide with fluid received from the fluid inlet for a designated time following treatment of the slide by the automated staining apparatus.
A bulk fluid wash module for an automated treatment apparatus for treating tissue samples disposed on slides, the bulk fluid wash module comprising: a body; a cavity disposed in the body, the cavity configured to receive a plurality of bulk fluids dispensed from a plurality of probes of a bulk fluid robot of the automated treatment apparatus, whereby the plurality of probes are configured to dispense the bulk fluids to the slides and to the cavity; and a scavenger port disposed in the body, the scavenger port in fluid communication with the cavity and configured to remove the bulk fluids from the cavity.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01L 19/00 - Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.
An apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
Blockchain-based workflow management for patient samples. In an embodiment, for each of a plurality of first devices, a request for a unique sample identifier is received from the first device, and, in response to the request, the unique sample identifier is generated and sent to the first device. Then, for each of a plurality of second devices and for each of a plurality of interactions, interaction information is received from the second device, a transaction is generated from the interaction information, and the transaction is recorded in an immutable ledger. The interaction information may comprise a unique sample identifier, a user identifier, a location, an event type, and a timestamp.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
39.
System and method of monitoring tissue samples to be processed by a tissue processor
A system for monitoring tissue samples to be processed by a tissue processor for a histopathology workflow, the system including: a scanner associated with the tissue processor arranged to scan an electronic sample identifier of at least one tissue sample to be processed by the tissue processor; an input module arranged to receive tissue processor workflow data indicative of a tissue processor workflow for the at least one tissue sample to be processed by selected ones of a plurality of processing stations in the tissue processor used for processing the at least one tissue sample; a monitoring module arranged to monitor properties of the at least one tissue sample processed at each of the selected ones of the processing stations and to record the properties of the at least one tissue sample in association with the electronic sample identifier in a sample record for the tissue processor workflow; and an output module arranged to output the sample record to one or more laboratory instruments for further processing the at least one tissue sample in a histopathology workflow. A tissue processor for processing tissue samples for a histopathology workflow is also provided. A method of monitoring tissue samples to be processed by a tissue processor for a histopathology workflow is also provided.
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
40.
METHOD OF PRODUCING A REAGENT ON-BOARD AN INSTRUMENT
The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.
A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.
A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
A bulk fluid wash module for an automated treatment apparatus for treating tissue samples disposed on slides, the bulk fluid wash module comprising: a body; a cavity disposed in the body, the cavity configured to receive a plurality of bulk fluids dispensed from a plurality of probes of a bulk fluid robot of the automated treatment apparatus, whereby the plurality of probes are configured to dispense the bulk fluids to the slides and to the cavity; and a scavenger port disposed in the body, the scavenger port in fluid communication with the cavity and configured to remove the bulk fluids from the cavity.
The present invention relates generally to methods and systems for generating a schedule of activities for an automated laboratory system including one or more banks of processing units at which activities are performed using various processing resources. The invention is of particular, but not exclusive, application to intriguing tissue samples disposed on slides using a plurality of reagents to stain the tissue samples.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G06Q 10/04 - Forecasting or optimisation specially adapted for administrative or management purposes, e.g. linear programming or "cutting stock problem"
G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
A slide tray assembly for an slide input module or an slide output module of an automated treatment apparatus for treating tissue samples disposed on slides, the slide tray assembly comprising: a slide tray; and a slide tray cover adjacent to the slide tray forming one or more voids between the slide tray and the slide tray cover for receiving slides therein, wherein the slide tray cover comprises an indent at one end of the slide tray cover so that a slide handling robot of the automated treatment apparatus and an operator of the automated treatment apparatus can access the slides in the voids via the indent.
A slide output module for an automated treatment apparatus for treating tissue samples disposed on slides, the slide output module comprising: a slide output tray assembly comprising a slide output tray adjacent to a slide output cover forming one or more voids between the slide output tray and the slide output tray cover for receiving slides therein, wherein the slide output tray cover comprises a first side with a fluid inlet in communication one of the voids, and a second side configured to form a hydration chamber with a slide in said one of the voids to maintain hydration of the slide with fluid received from the fluid inlet for a designated time following treatment of the slide by the automated staining apparatus.
A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
A cassette for arranging and loading reagent containers into a staining apparatus includes a housing with a base and walls upstanding from the base to define a plurality of compartments. Each compartment is configured for receiving a reagent container. The housing includes two portions, pivotably coupled together at respective first ends thereof, and configured to pivot between an open configuration and a closed configuration. Each portion of the housing in the closed configuration is received within a corresponding one of an adjacent pair of channels located within the staining apparatus when the cassette is loaded therewithin.
G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
B05C 3/02 - Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A method of operating a tissue processor for processing tissue samples. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and thereby automatically determining whether the reagent is suitable for processing tissue samples in the tissue processor. Also, a tissue processor for processing tissue samples and a container for storing tissue samples.
Blockchain-based consumables management with support for offline instruments. In an embodiment, a user device scans a first machine-readable code on a consumable, scans a second machine-readable code displayed on a display of an instrument that is not communicatively connected to a blockchain network, decodes a consumable code from the first machine-readable code, decodes an instrument code from the second machine-readable code, broadcasts a transaction message, comprising the consumable code and the instrument code, to the blockchain network, receives a use code from the blockchain network, encodes the use code into a third machine-readable code, and displays the third machine-readable code, on a display of the user device, for scanning by the instrument.
G06Q 10/08 - Logistics, e.g. warehousing, loading or distributionInventory or stock management
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G06K 19/06 - Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
The present invention relates to a fluid transport system for an automated slide treatment apparatus for treating one or more tissue samples disposed on slides, whereby the slide treatment apparatus includes a plurality of slide treatment modules arranged to receive ones of the slides, and the fluid transport system includes a fluid dispensing robot configured by a controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules to treat said one or more tissue samples respectively.
A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
A method of operating a tissue processor for processing tissue samples is provided. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes the steps of conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring, by means of the at least one sensor, a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and automatically determining, based on a result of checking, whether the reagent is suitable for processing tissue samples in the tissue processor. A tissue processor for processing tissue samples is also provided. A container is also provided for storing tissue samples for processing in a tissue processor.
A system for monitoring tissue samples to be processed by a tissue processor for a histopathology workflow, the system including: a scanner associated with the tissue processor arranged to scan an electronic sample identifier of at least one tissue sample to be processed by the tissue processor; an input module arranged to receive tissue processor workflow data indicative of a tissue processor workflow for the at least one tissue sample to be processed by selected ones of a plurality of processing stations in the tissue processor used for processing the at least one tissue sample; a monitoring module arranged to monitor properties of the at least one tissue sample processed at each of the selected ones of the processing stations and to record the properties of the at least one tissue sample in association with the electronic sample identifier in a sample record for the tissue processor workflow; and an output module arranged to output the sample record to one or more laboratory instruments for further processing the at least one tissue sample in a histopathology workflow. A tissue processor for processing tissue samples for a histopathology workflow is also provided. A method of monitoring tissue samples to be processed by a tissue processor for a histopathology workflow is also provided.
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
58.
IMPROVEMENTS IN HISTOLOGICAL TISSUE SPECIMEN PROCESSING
A method of operating a tissue processor for processing tissue samples is provided. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes the steps of conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring, by means of the at least one sensor, a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and automatically determining, based on a result of checking, whether the reagent is suitable for processing tissue samples in the tissue processor. A tissue processor for processing tissue samples is also provided. A container is also provided for storing tissue samples for processing in a tissue processor.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
59.
A SYSTEM AND METHOD OF MONITORING TISSUE SAMPLES TO BE PROCESSED BY A TISSUE PROCESSOR
A system for monitoring tissue samples to be processed by a tissue processor for a histopathology workflow, the system including: a scanner associated with the tissue processor arranged to scan an electronic sample identifier of at least one tissue sample to be processed by the tissue processor; an input module arranged to receive tissue processor workflow data indicative of a tissue processor workflow for the at least one tissue sample to be processed by selected ones of a plurality of processing stations in the tissue processor used for processing the at least one tissue sample; a monitoring module arranged to monitor properties of the at least one tissue sample processed at each of the selected ones of the processing stations and to record the properties of the at least one tissue sample in association with the electronic sample identifier in a sample record for the tissue processor workflow; and an output module arranged to output the sample record to one or more laboratory instruments for further processing the at least one tissue sample in a histopathology workflow. A tissue processor for processing tissue samples for a histopathology workflow is also provided. A method of monitoring tissue samples to be processed by a tissue processor for a histopathology workflow is also provided.
G16H 15/00 - ICT specially adapted for medical reports, e.g. generation or transmission thereof
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
60.
IMPROVEMENTS IN HISTOLOGICAL TISSUE SPECIMEN PROCESSING
A method of operating a tissue processor for processing tissue samples is provided. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes the steps of conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring, by means of the at least one sensor, a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and automatically determining, based on a result of checking, whether the reagent is suitable for processing tissue samples in the tissue processor. A tissue processor for processing tissue samples is also provided. A container is also provided for storing tissue samples for processing in a tissue processor.
A sample processing assembly for treatment of a sample on a substrate, the assembly including: a mounting surface for the substrate; and a cover member, the cover member being movable between an open position and a substantially closed position, wherein, when the substrate is placed in the assembly and the cover member is in the substantially closed position, a reaction chamber is formed for processing the sample between the cover member and the substrate, and wherein the mounting surface provides for an air gap between the substrate and the mounting surface. An instrument for treatment of a sample on a substrate including at least one sample processing assembly as provided herein. A method of placing a substrate in a sample processing assembly is also provided.
A server computer system connected to a first communications network. The server computer includes an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system. The UI instances control respective virtual pods representing one or more of said biological reagent instruments.
G05B 15/02 - Systems controlled by a computer electric
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04L 29/06 - Communication control; Communication processing characterised by a protocol
H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
A server computer system connected to a first communications network. The server computer includes an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system. The UI instances control respective virtual pods representing one or more of said biological reagent instruments.
G05B 15/02 - Systems controlled by a computer electric
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
H04L 67/125 - Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemicals for use in industry and science; chemical reagents
for non-medical purposes; diagnostic reagents and
preparations, except for medical or veterinary use;
diagnostic preparations used in science; chemical reagents
and diagnostic preparations for use in research laboratories
and for use in industry. Pharmaceutical and veterinary preparations including
reagents for medical and diagnostic purposes; diagnostic
preparations; reagents containing primary antibodies;
chemical reagents and diagnostic preparations for medical
and veterinary purposes; medical diagnostic reagents;
clinical medical reagents; reagents for
immuno-histochemistry detection and in situ-hybridisation
detection; in situ-hybridisation probes; epitope retrieval
solutions; enzymes and enzyme preparations for medical and
diagnostic purposes; histological dye and stain solutions;
dewaxing and wash buffers used with the aforementioned
preparations; diagnostic preparations for clinical or
medical laboratory use. Diagnostic apparatus and instruments, not for medical
purposes, including, apparatus for staining and/or
visualization of tissue or cell based samples for diagnostic
or scientific use; apparatus for detection of tissue and/or
cell based samples not for medical purposes; recorded and
downloadable software for identifying and diagnosing cancer
and other diseases and processing digital images; analysis
apparatus for laboratory use for analyzing the results of
tissues and cell based samples obtained through operation of
tissue and cell sample staining apparatus; measuring
apparatus used to identify and/or diagnose cancer and other
diseases, not for medical use; diagnostic testing apparatus
incorporating chemical reagents not for medical use. Diagnostic apparatus and instruments for medical use
including, apparatus for staining and/or visualization of
tissue or cell based samples for diagnostic or medical use;
apparatus for detection of tissue and/or cell based samples,
all for medical purposes; medical analysis and medical
measuring apparatus, including, medical diagnostic
instruments for the analysis of body fluids and tissue for
medical diagnostic uses; medical apparatus and instruments;
apparatus for use in medical analysis; diagnostic apparatus
for medical purposes; testing apparatus for medical
purposes; apparatus for promoting and controlling reaction
on microarrays or under slide covertiles; in-vitro
diagnostic testing apparatus incorporating chemical reagents
(for medical use); slides for surgical use. Medical research; installation and integration of software,
including within existing hospital and laboratory
infrastructure; maintenance, servicing, updating and
upgrading of software; all the aforementioned for use in
connection with medical analysis, diagnosis and research.
A sample, embedded in a paraffin block, is placed on a tissue cassette which carries a label which may be a bar code. When the sample is processed, the cassette is given to a microtome operator who scans the label. Scanning causes information to be displayed on a screen and the operator verifies that what is on the screen matches what was on the label. The paraffin block is then placed in a microtome chuck and sections are cut from the block. A number of slide labels related to the cassette label are printed for the sections. If the operator does not verify that the information displayed on the screen matches the information on the cassette label and/or does not place the paraffin block in the microtome chuck within an allocated time interval after scanning the cassette label, dispensing and labeling of slides and/or operation of the microtome is prevented.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G01N 1/36 - Embedding or analogous mounting of samples
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G06Q 50/24 - Patient record management (processing of medical or biological data for scientific purposes G06F 19/00)
G06Q 10/06 - Resources, workflows, human or project managementEnterprise or organisation planningEnterprise or organisation modelling
G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
G06K 7/14 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations, namely, pharmaceutical preparations for histological and cytological tissue processing applications and reagents for medical and medical diagnostic purposes; diagnostic preparations for medical use; reagents containing primary antibodies for medical use; chemical reagents and diagnostic preparations for medical and veterinary purposes; medical diagnostic reagents; clinical medical reagents; reagents for immuno-histochemistry detection and in situ-hybridisation detection for medical use; double, triple or multiple in situ hybridisation probes for application of multiple antibodies or probes in the same staining procedure to a tissue section during IHC staining for medical, research or veterinary purposes; epitope retrieval solutions for medical use; enzymes and enzyme preparations for medical and diagnostic purposes; diagnostic histological dye and stain solutions for medical use; dewaxing and wash buffers used with the aforementioned preparations for use in disease testing; diagnostic preparations for clinical or medical laboratory use Diagnostic apparatus and instruments, not for medical purposes, including, apparatus for staining and/or visualization of tissue or cell based samples for diagnostic or scientific use; apparatus for detection of tissue and/or cell based samples not for medical purposes; recorded and downloadable software for identifying and diagnosing cancer and other diseases and processing digital images; analysis apparatus for laboratory use for analyzing the results of tissues and cell based samples obtained through operation of tissue and cell sample staining apparatus; measuring apparatus used to identify and/or diagnose cancer and other diseases, not for medical use; diagnostic testing apparatus incorporating chemical reagents not for medical use Apparatus for detection of tissue and/or cell based samples, all for medical purposes; histopathology instruments; haematology instruments for clinical purposes, namely tissue staining instruments; diagnostic medical apparatus for performing immunohistochemistry and in situ-hybridisation staining reactions, and histological and pathological staining; in situ hybridisation probes; apparatus for medical use promoting and controlling reaction on microarrays or under slide covertiles used in conjunction with histopathology instruments, tissue staining instruments and diagnostic medical apparatus for performing immunohistochemistry and in situ hybridisation staining reactions and histological and pathological staining; in-vitro diagnostic testing apparatus incorporating chemical reagents for medical use; medical specimen collection slides for specimen collection in surgery [ Medical research; installation and integration of computer software, including within existing hospital and laboratory infrastructure; maintenance, updating and upgrading of software; all the aforementioned for use in connection with medical analysis, diagnosis and research ]
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computers; computer hardware, computer software,
downloadable software applications (apps); electronic
apparatus, software, downloadable software applications, all
for remote control, management, operation of industrial
equipment, laboratory apparatus or equipment, machinery,
electronic apparatus or instruments, scientific apparatus,
medical apparatus; remote monitoring apparatus, computer
hardware and software for remote processing; app
(application) for download to mobile devices, application
software for mobile devices and mobile operating systems,
computer software, including for use on mobile phones or
other mobile data playback devices; downloadable computer
software for research and clinical apparatus; downloadable
scientific and medical multimedia data, including, high
resolution digital images of research and clinical apparatus
dashboard data via the internet; downloadable software in
the nature of a mobile application for database management
and cloud-based storage in the field of research and
clinical pathology; computer software for scientific
apparatus and instruments, including, portable or mobile
devices; operating software for histological and cytological
scientific and diagnostic apparatus and laboratory
equipment; computer software for use in data integration,
management, and analysis, all including in the fields of
virtual microscopy, digital pathology, digital hematology
and medical information technology; computer software for
centralizing and presenting data and information collected
using laboratory instruments; computer software that
provides web-based access to applications and services
through a web operating system or portal interface;
downloadable software in the field of pathology for mobile
phones and mobile computers; computer hardware, including,
central processing units, servers, scanners, monitors and
multiple-screen display monitors, and computer software for
use in laboratories for viewing, integration with other
data, management, and analysis, all including in the fields
of virtual microscopy, digital pathology, digital hematology
and medical information technology; diagnostic apparatus and
instruments, not for medical purposes, including apparatus
for staining and/or visualisation of tissue or cell based
samples for diagnostic or scientific use; apparatus for
detection of tissue and/or cell based samples and scientific
apparatus for high speed cell and/or bead sorting and
analysis; analysis apparatus for laboratory use; measuring
apparatus not for medical use; instruments used in histology
and cytology, including, microscopes, microtomes, cryostats,
microscopes and scanners, sectioning instruments in the
nature of automated laboratory equipment for cutting
specimens, computer software for use in operating
microscopes and sectioning equipment; cover slipping
machines for slides, tissue infiltration and embedding
apparatus, including, microtomes, cryostats, microscopes and
scanners in the field of histology; tissue infiltration
apparatus in the field of histology; tissue embedding
machines in the field of histology; sample staining
apparatus in the field of histology; automatic contrasting
instruments, including, automated slide stainers for use in
medical and scientific laboratories; sample carriers for
microscopic specimens, such as tissue sections from tumors,
sold empty; image analysis devices, including, microscopes,
research and pathology slide scanners; computer hardware for
the electronic recording, storage and representation of
laboratory research images; slide scanners for laboratory
use, including, cameras for use in recording material on
microscope slides; virtual microscopes, including,
microscopes featuring digital cameras for use in making
images available via communications networks; electronic
reading devices and/or writing devices, namely, barcode
scanners and label printers for use in coding of cassettes,
microscope slides, sample carriers, storage and transport
apparatus; electronic reading and writing devices in this
class, namely, computer chip encoding and reading equipment
for reading and creating electronic labels for sample
carriers, storage and transport apparatus and on laboratory
apparatus and devices of the type mentioned above and on
parts of the apparatus and devices; replacement parts for
the afore-mentioned apparatus and devices; operating
software for the afore-mentioned apparatus and devices;
downloadable software in the nature of a mobile application
for database management and cloud-based storage in the field
of digital pathology. Design and development of computer software, application
software development for using with scientific and optical
instruments and apparatus; software as a service; hosting of
software as a service; software engineering; writing of
computer software; information technology (it) services
(computer hardware, software and peripherals design and
technical consulting); diagnosis of faults in computer
software; installation, repair and maintenance of computer
middleware and software; design of computer software
application solutions; application service provider (asp)
services featuring computer software; application service
provider (asp) services featuring software for authoring,
downloading, transmitting, receiving, editing, extracting,
encoding, decoding, displaying, storing and organizing text,
graphics, images, and electronic publications; scientific
and technological services and research and design relating
thereto; industrial analysis and research services; design
and development of computer hardware and software;
scientific and technological services, including, scientific
analysis and testing, technological research and design,
consulting, including, scientific analysis and testing,
technological research and design, research, computer
hardware and software development, algorithm development and
design relating to the detection, identification,
classification, and assessment of known and unknown
materials.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computers; computer hardware; computer software for the remote monitoring of medical laboratory apparatus, laboratory inventory and laboratory consumables, for use in the fields of pathology and haematology; downloadable software applications for mobile phones and handheld computers, namely, software for the remote monitoring of medical laboratory apparatus, laboratory inventory and laboratory consumables, for use in the fields of pathology and haematology; electronic apparatus for remote control management and operation of industrial equipment, laboratory apparatus or equipment; electronic apparatus for the remote control of industrial and laboratory operations; Wireless controllers to monitor and control the functioning of other electronic devices; software and downloadable software applications for the remote control, management and operation of industrial equipment, laboratory apparatus or equipment, machinery, electronic apparatus or instruments, scientific apparatus used in the fields of pathology and haematology; Remote monitoring apparatus, namely, remote sensors for monitoring stock inventory levels; remote monitoring apparatus, namely, electronic apparatus for the remote control of industrial and laboratory operations; remote processing apparatus, namely, computer hardware and software for remote processing of stock inventory levels, status of industrial and laboratory operations and cancer diagnosis results; Downloadable computer software for research and clinical apparatus, namely, for use in remotely monitoring and controlling the function and status of laboratory operations and electronic storage and transmission of data relating to said apparatus; downloadable scientific and medical multimedia data, namely, high resolution digital images of research and clinical apparatus dashboard data via the Internet; downloadable software in the nature of a mobile application for database management and cloud-based storage in the field of research and clinical pathology; Computer software for scientific apparatus and instruments, including, portable or mobile devices, in the form of computer firmware, operating software, software that allows for the remote monitoring and control of the apparatus and instruments and software that allows for the electronic storage and transmission of data relating to said apparatus and instruments; computer operating software for histological and cytological scientific and diagnostic apparatus and laboratory equipment; computer software for use in data integration with other data, management, and analysis, all including in the fields of virtual microscopy, digital pathology, digital haematology and medical information technology; computer software for centralizing and presenting data and information collected using laboratory instruments; computer software that provides web-based access to applications and services through a web operating system or portal interface; downloadable software in the field of pathology for mobile phones and mobile computers for laboratory inventory management, remote monitoring and control of the function and status of pathology laboratories, electronic storage and transmission of pathological data; computer hardware, including, central processing units, servers, scanners, monitors and multiple-screen display monitors, for use in laboratories for viewing, integration with other data, management, and analysis, all including in the fields of virtual microscopy, digital pathology, digital haematology and medical information technology; computer software for use in laboratories for viewing, integration with other data, management, and analysis, all including in the fields of virtual microscopy, digital pathology, digital haematology and medical information technology; computer software for use in operating microscopes and sectioning equipment; computer hardware for the electronic recording, storage and representation of laboratory research images Design and development of computer software for use with scientific and optical instruments and apparatus; software as a service featuring software for the remote monitoring of medical laboratory apparatus, laboratory inventory and laboratory consumables, for use in the fields of pathology, haematology, laboratory inventory management, and remote monitoring of medical laboratory apparatus; hosting of software for others as a service; software engineering in the nature of design and development of computer software for others; writing of computer software in the nature of design and development of computer software for others; information technology (IT) consulting services in the nature of computer hardware, software and peripherals design and technical consulting; technical support services, namely, troubleshooting of computer software problems in the nature of diagnosis of faults in computer software; installation, repair and maintenance of computer middleware and software; design of computer software application solutions; application service provider (asp) services featuring computer software for the remote monitoring of medical laboratory apparatus, laboratory inventory and laboratory consumables, for use in the fields of pathology and haematology; application service provider (asp) services featuring software for authoring, downloading, transmitting, receiving, editing, extracting, encoding, decoding, displaying, storing and organizing text, graphics, images, and electronic publications; [ scientific and technological services, namely, scientific and biological research in the fields of pathology, haematology, medical diagnostics, and cancer diagnosis; research and design relating to scientific and technological services, namely, the research and design of laboratory and diagnostic apparatus and instruments used for scientific purposes, algorithm development and design for detection, identification, classification and assessment of known and unknown materials; ] design and development of computer hardware and software; none of the foregoing services involving the collecting, analysing or reporting of market data
A system for customising management of one or more instruments in a laboratory includes a user device, an interface module and an instrument module. The user device is adapted to receive inputs from a user and has a device processor for processing the received inputs and instrument data from the one or more instruments, as well as a device display for displaying instrument information. The interface module is communicatively coupled with the user device and the one or more instruments and configured to convert instrument data in a first format generated by an instrument processor to a second format for processing by the device processor. The instrument module is configured to cause the device processor to provide customised instrument information on the device display. A method of deploying a platform for integrated management of instruments is also disclosed.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
G06Q 50/22 - Social work or social welfare, e.g. community support activities or counselling services
A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
A slide transport system for an automated slide treatment apparatus having slide treatment modules for receiving slides and a fluid dispensing robot configured by a controller to dispense reagents to the slides is disclosed. The slide transport system includes a slide transport robot configured by the controller to move the slides to and from the slide treatment modules and a slide transport device disposed on the slide transport robot and configured by the controller to releasably hold the slides. A slide handling head on the slide transport robot moves a closure body of a slide treatment module from a normally closed to an open position to move slides in the slide treatment module. The slide transport device is configured by the controller to release a slide when located in the slide treatment module, when the closure body is in the open position.
A fluid transport system for an automated slide treatment apparatus having slide treatment modules is disclosed. The fluid transport system including a fluid dispensing robot configured by a controller to dispense a plurality of reagents to slides received in the slide treatment modules. The fluid dispensing robot includes pumping means configured by the controller to pump the reagents to be dispensed from a plurality of corresponding reagent containers; a probe having a body arranged to store one or more of the reagents pumped via the pumping means so as to prime the probe with said one or more of the reagents to be dispensed; and a well disposed on the body of the probe to store further of the reagents primed to be dispensed.
A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
G05B 15/02 - Systems controlled by a computer electric
H04L 29/06 - Communication control; Communication processing characterised by a protocol
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
H04L 29/08 - Transmission control procedure, e.g. data link level control procedure
Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently.
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with one or more mixing wells 10 for dilution of a concentrate 12 with a diluent to provide the reagent at the required concentration.
A thermal system for controllably altering a temperature within a reaction chamber in a sample processing assembly is described. The reaction chamber is bounded by a substrate and cover member in the sample processing assembly. The thermal system includes at least one thermal generator for generating temperature changes, one or more transfer layers for transferring temperature changes between the thermal generator and the sample on the substrate and a fluid isolator for isolating the thermal generator from fluid dispensed into the reaction chamber.
A slide transport system for an automated slide treatment apparatus having slide treatment modules for receiving slides and a fluid dispensing robot configured by a controller to dispense reagents to the slides is disclosed. The slide transport system includes a slide transport robot configured by the controller to move the slides to and from the slide treatment modules and a slide transport device disposed on the slide transport robot and configured by the controller to releasably hold the slides. A slide handling head on the slide transport robot moves a closure body of a slide treatment module from a normally closed to an open position to move slides in the slide treatment module. The slide transport device is configured by the controller to release a slide when located in the slide treatment module, when the closure body is in the open position.
A fluid transport system for an automated slide treatment apparatus having slide treatment modules is disclosed. The fluid transport system including a fluid dispensing robot configured by a controller to dispense a plurality of reagents to slides received in the slide treatment modules. The fluid dispensing robot includes pumping means configured by the controller to pump the reagents to be dispensed from a plurality of corresponding reagent containers; a probe having a body arranged to store one or more of the reagents pumped via the pumping means so as to prime the probe with said one or more of the reagents to be dispensed; and a well disposed on the body of the probe to store further of the reagents primed to be dispensed.
A sample processing assembly for treatment of a sample on a substrate includes a mounting surface for the substrate and a closure body configured to releasably retain a cover member. The closure body is movable between an open position and a substantially closed position. When a substrate is placed in the assembly and the closure body is in the substantially closed position while retaining a cover member, a reaction chamber is formed for processing a sample. A cover member for use with the sample processing assembly is also provided.
A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.
A server computer system connected to a first communications network and including: an instrument communications component configured to communicate with and control a plurality of biological reagent instruments using the first communications network; and a user interface component configured to cause user interface (UI) instances to be displayed by a client computer device connected by a second communications network to said server computer system; wherein said UI instances control respective virtual pods representing one or more of said biological reagent instruments.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
86.
COVER MEMBER, METHOD AND TREATMENT MODULE FOR TREATING A BIOLOGICAL SAMPLE ON A SUBSTRATE
A cover member for a substrate supporting a biological sample comprises first and second opposing ends, first and second opposing surfaces, a void in the second surface which, when juxtaposed with a substrate, forms a chamber, and a fluid inlet toward the first end and in fluid communication with the void. The void is bounded by void walls having one or more contoured regions for enhancing fluid movement within the chamber. A treatment module for a biological sample comprises the cover member, a support surface for a substrate bearing the biological sample and clamp means operable to releasably retain the cover member in juxtaposition with the substrate for an incubation period. A method for incubating the biological sample with one or more reagents uses the cover member.
An automated method and system for treating one or more tissue samples disposed on slides, the system comprising : a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to said ones of the slides received in the slide treatment modules via an output nozzle disposed on the at least one fluid dispensing robot to treat said one or more tissue samples respectively; and at least one pumping means for pumping said reagents to the output nozzle of the at least one fluid dispensing robot from a plurality of reagent containers comprising said reagents, wherein the at least one fluid dispensing robot is configured by the controller to dispense said reagents in a predetermined sequence for each of the slide treatment modules to treat the one or more tissue samples disposed on each of the slides independently.
Apparatus for treating biological samples disposed on substrates, including: an input buffer for receiving one or more substrate holders each being adapted to support a plurality of the substrates; a treatment zone including a plurality of treatment stations each being adapted to receive one of the substrates; a reagent dispenser configured by a controller to dispense reagents to the substrates at the treatment stations; a substrate transport device configured by the controller to transport individual substrates between the substrate holders in the input buffer and the treatment stations.
G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
C07C 245/10 - Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems
C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position. When the mould and cassette are moved to a second position, a projection on the rack separates the mould from the cassette, to facilitate easy removal. Also disclosed is a mould for a tissue cassette having projections for holding the mould to a rack, so that the tissue cassette is not in contact with the mould.
An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batched forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispense reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In on embodiment, the group fluid dispenser dispense antibodies, probes, detection reagents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispense from dispensing bulk reagents to all slides.
A mixing vial is provided for an automated biological reaction apparatus typically used for staining tissue samples in Immuno-histological and in-situ hybridisation reactions. The mixing vial allows reagents placed on the apparatus to be mixed together to form additional or blended reagents. A reagent dispenser mounted on a robotic arm withdraws reagent from the reagent containers and deposits it into one of the mixing vials. Several reagents can be deposited into each vial. Mixing is undertaken by withdrawing the reagents in a vial and re-dispensing the reagent back into the vial. Mixing may take place between the operation of other tasks performed by the apparatus, and a scheduler is used to ensure blended reagent is provided before it is required in one of the processes undertaken on the apparatus. The apparatus is able to automatically identify which blended reagents are required and when they must be applied to provide an appropriate schedule that minimises time taken to stain samples.
A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.
The present invention relates to a composition and method for handling tissue samples for analysis. In particular the present invention relates to a composition and method for orientating tissue for histological and/or pathological laboratory analysis.
An apparatus and method for applying reagents to tissue mounted on slides, in the field of histology is disclosed. The apparatus holds a number of slides, in slide trays, which are loaded onto the apparatus. Each slide tray forms a batch of slides, with all the batches forming a group. The apparatus holds a number of reagents, grouped into a first group comprising bulk type reagents, and a second group comprising antibodies or probes, and detection systems, for identifying elements of the tissue. A group fluid dispenser, in the form of a robot arm, dispenses reagents to the group of slides. Each batch of slides has its own batch fluid dispenser to dispense reagents onto the batch of slides. In one embodiment, the group fluid dispenser dispenses antibodies, probes, detection regents to all slides depending on the protocol defined for each slide, and the batch dispensers dispense bulk reagent to each batch, thus freeing the group fluid dispenser from dispensing bulk reagents to all slides.
A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position. When the mould and cassette are moved to a second position, a projection on the rack separates the mould from the cassette, to facilitate easy removal. Also disclosed is a mould for a tissue cassette having projections for holding the mould to a rack, so that the tissue cassette is not in contact with the mould.
A method an apparatus for identifying slides is disclosed, where samples such as tissue sample mounted to slides are labeled with information, and an image of the information is captured by a processing instrument. The image is analyzed, for example using optical character recognition, and information extracted from the image is used to determine the test to be applied to the slide by the processing instrument. Where information about the slide cannot be extracted from the image, the image is presented to a user to that the slide information, such as its identity or the test to be applied, may be selected by the user to allow the slide to be processed.
G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
G06K 9/64 - Methods or arrangements for recognition using electronic means using simultaneous comparisons or correlations of the image signals with a plurality of references, e.g. resistor matrix
A sample, which is embedded in a paraffin block, is placed on a tissue cassette (22) which carries a label (20) which may a bar code. When the sample is to be processed, the cassette is given to a microtome operator who scans the label (20) with, for example, a bar code reader (4). Scanning causes information to be displayed on a screen (12) and the operator verifies that what is on the screen matches what was on the label. The paraffin block is then placed in a microtome chuck (26) and sections are cut from the block. Concurrently with, or prior to sectioning, a number of slides (18) are dispensed (2) and are printed with a label (16) so that the sections can be mounted thereon. The slide label (16) is related to the cassette label (20). If the operator does not verify that the information displayed on the screen matches the information on the cassette label (20) and/or does not place the paraffin block in the microtome chuck (26) within an allocated time interval after scanning the cassette label (20), dispensing and labelling of slides (18) and/or operation of the microtome is prevented. This ensures accurate identification of samples within a laboratory as it does allow the operator the opportunity lose track of which samples were being processed.
A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed, leaving the tissue sample correctly oriented in embedding material, mounted to a support, ready for microtoming.
