01 - Chemical and biological materials for industrial, scientific and agricultural use
42 - Scientific, technological and industrial services, research and design
Goods & Services
Protein and nucleic acid preparation kits consisting
primarily of reagents for scientific research purposes. Chemical and medical laboratory services in the field of
biotechnology and pharmaceuticals.
01 - Chemical and biological materials for industrial, scientific and agricultural use
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Protein and nucleic acid preparation kits consisting primarily of reagents for scientific research purposes. (1) Chemical and medical laboratory services in the field of biotechnology and pharmaceuticals.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely instruments for the acoustic manipulation of biological or chemical samples and preparations; laboratory instruments for DNA/RNA shearing, chromatic, proteomics, cell lysis, formulation, and FFPE extraction Chemical and medical research laboratory services in the field of biotechnology and pharmaceuticals; Scientific research, scientific analytical research and scientific research consulting services in the field of next-generation sequencing (NGS), library, and sample preparation therefor
A sample holder for collecting a liquid sample, such as blood. The holder can include a vessel, a conduit having a proximal end extending from the vessel and a distal end positioned in the vessel, and a cap configured to engage with the vessel and create pressure to move a liquid sample in the conduit to move from the proximal end to the distal end. A desiccant can be used to dry a blood sample during storage.
A sample holder for collecting a liquid sample, such as blood. The holder can include a vessel, a conduit having a proximal end extending from the vessel and a distal end positioned in the vessel, and a cap configured to engage with the vessel and create pressure to move a liquid sample in the conduit to move from the proximal end to the distal end. A desiccant can be used to dry a blood sample during storage.
A sample holder shuttle for holding a sample holders for laboratory processing, such as PCR thermal cycling, focused acoustic energy treatment and others. Sample holders can be received at openings of the shuttle such that a plurality of sample holders can be held by the shuttle and moved or otherwise manipulated simultaneously. A cover can engage with sample holders, e.g., to press the sample holders downwardly into contact with the shuttle.
A sample holder shuttle for holding a sample holders for laboratory processing, such as PCR thermal cycling, focused acoustic energy treatment and others. Sample holders can be received at openings of the shuttle such that a plurality of sample holders can be held by the shuttle and moved or otherwise manipulated simultaneously. A cover can engage with sample holders, e.g., to press the sample holders downwardly into contact with the shuttle.
A sample holder for collecting a liquid, sample, such as blood. The holder can include a vessel, a. conduit having a proximal end extending from the vessel and a. distal end positioned in the vessel, and a cap configured to engage with the vessel and create pressure to move a liquid sample in the conduit, to move from the proximal end to the distal end. The vessel can include a fluid pathway to vent fluid from the vessel as the liquid sample is moved from the conduit into the vessel, and the cap can seal the fluid pathway closed. A desiccant can be used to support, the conduit in the vessel and dry a blood sample during storage.
A sample holder for collecting a liquid sample, such as blood. The holder can include a vessel, a conduit having a proximal end extending from the vessel and a distal end positioned in the vessel, and a cap configured to engage with the vessel and create pressure to move a liquid sample in the conduit to move from the proximal end to the distal end. The vessel can include a fluid pathway to vent fluid from the vessel as the liquid sample is moved from the conduit into the vessel, and the cap can seal the fluid pathway closed. A desiccant can be used to support the conduit in the vessel and dry a blood sample during storage.
Apparatus and method for disassociating protein complexes, e.g., to allow recovery and/or analysis of at least one of the proteins or metabolites released from a complex. Disassociation is done using focused acoustic energy and without solvents, excessive heat or other process conditions that damage proteins or metabolites. Disassociation may be followed by depletion of one of the proteins released from complexes, e.g., to allow another protein or metabolite released from the complexes to be recovered.
Apparatus and method for disassociating protein complexes, e.g., to allow recovery and/or analysis of at least one of the proteins or metabolites released from a complex. Disassociation is done using focused acoustic energy and without solvents, excessive heat or other process conditions that damage proteins or metabolites. Disassociation may be followed by depletion of one of the proteins released from complexes, e.g., to allow another protein or metabolite released from the complexes to be recovered.
A sample holder for holding a liquid sample for laboratory processing, such as PCR thermal cycling. The sample holder includes at least one vessel having a bottom and sidewall defining an interior volume and a rim defining an opening to the interior volume. The vessel has a first portion that defines at least a part of the bottom and sidewall of the vessel and is made of a first material, and a second portion that defines the rim of the vessel and is made of a second material different from the first material.
Apparatus and method for separating whole cells from a mixture, e.g., including liquid, other cell types, nucleic acid material, or other components. Focused acoustic energy may be used to move whole cells in a chamber so that the cells exit the chamber via a first outlet rather than a second outlet. A filter may, or need not, be used to assist in separation.
Apparatus and method for removing liquid from exterior surfaces of sample wells in a well plate. Wells that have water or other liquid on an exterior surface, e.g., after acoustic energy treatment in a water bath, may have the liquid removed by contacting the exterior surfaces of the sample wells with an absorbent material. A pad made of absorbent material may have a plurality of openings arranged to receive an array of sample wells inserted into the openings so that liquid can be removed from each of the sample wells.
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory equipment, namely, acoustical cuvettes for use with instruments for the acoustic manipulation of biological or chemical samples and preparations
Focused acoustic treatment of samples may be used to differentially shear different fragment lengths of DNA or other nucleic acid portions of a sample. Relatively larger fragment lengths may be sheared while smaller fragment lengths are unaffected by the focused acoustic based shearing.
Methods and systems for preparing crystalline particle compositions using focused acoustic processing to control a number or count of crystalline particles generated. Peak incident power of focused acoustic energy used to cause primary nucleation kinetics of a solute may be adjusted to adjust the number or count of crystalline particles.
cfDNA reference material, for example, for use in verifying the accuracy and effectiveness of a diagnostic test, is generated from chromatin which may be sourced from whole cells. The chromatin may be treated with formaldehyde to form crosslinks between DNA and histones, for example, while the chromatin is contained within nuclear and/or plasma membranes. The fixed chromatin may be sheared by acoustic energy, which may also be used to lyse cell membranes within which the fixed chromatin may be contained. The sheared chromatin may be treated with an enzyme, such as micrococcal nuclease, to digest chromatin in linker regions of the DNA between nucleosomes and generate nucleosome material for use as cfDNA reference material.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples and preparations Chemical and medical laboratory services in the field of biotechnology and pharmaceuticals
28.
Methods and apparatuses for processing blood and other biological samples
Systems and methods for the high yield extraction and recovery of higher quality target molecule(s) (e.g., DNA, RNA, protein, lipids, metabolites) from blood spots. High quality DNA recovered from dried blood spots can be an input source for high throughput analytical methods, such as for polymerase chain reaction (e.g., qPCR) and/or next generation sequencing (NGS). In various embodiments, at least 20.0 nanograms of nucleic acid (e.g., DNA, RNA), or at least 8.0 milligrams of protein, may be extracted and recovered per an amount of dried blood corresponding to approximately 5 microliters of fresh blood. In some embodiments, a majority (e.g., greater than 50%, greater than 60%, up to 95-100%) of the nucleic acid that is extracted and recovered from the blood spot via focused acoustics may be of a quality suitable for amplification via PCR or NGS.
A sample holder and method for separating components of a viscous sample, such as a sputum sample, in a vessel having a porous element. Liquid may be flowed through the vessel during acoustic energy treatment, which may disrupt the viscous sample. Smaller components of the sample may pass through the porous element with liquid introduced into the vessel. Larger components, such a microbes, may be captured by the porous element and may remain intact and viable for subsequent analysis. The porous element may be removable from the vessel to recover the microbes.
Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.
Methods and apparatus for transmitting acoustic energy to a liquid sample within a vessel are described. The acoustic energy may have a peak incident power to enhance cooling of the sample.
Systems and methods for collecting blood and other liquid samples. A sample holder may include a cap and porous element arranged to receive a blood or other liquid sample. The porous element may be stored in a sealed container, e.g., immediately after blood sample collection, and the sample dried while sealed in the container.
Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The phase change couplant may be solid before and after treatment, but liquid during treatment to improve acoustic energy transmission charactersitics.
C12N 13/00 - Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
C12N 1/00 - Microorganisms, e.g. protozoaCompositions thereofProcesses of propagating, maintaining or preserving microorganisms or compositions thereofProcesses of preparing or isolating a composition containing a microorganismCulture media therefor
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Nucleic acid preparation kits consisting primarily of reagents for scientific research purposes; chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Biomolecule extraction kits consisting primarily of reagents for research purposes; chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Biomolecule extraction kits consisting primarily of reagents for research purposes; chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry.
37.
Acoustic energy mediation of genetic fragmentation
A treatment vessel may allow a user, or automated system, to manipulate sample material within a treatment area during processing (e.g., focused acoustic treatment), as well as subject the sample material to a staged processing protocol. The vessel may include openings for receiving/discharging the sample material. Walls within the vessel may be movable between various positions, to permit or obstruct flow of sample material into or out from a treatment area. The wall(s) may push the sample material within the vessel, as well as adjust pressure levels within the treatment area. In some embodiments, an acoustic treatment system may include a flexible coupling medium that may be deformed toward the vessel upon an application of suitable pressure thereto. When the medium presses up against the vessel, defects (e.g., particles, bubbles, interfaces, etc.) that may otherwise be present along the acoustic wave path may be reduced.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples and preparations; scientific, nautical, surveying, photographic, cinematographic, optical, weighing, measuring, signalling, checking [supervision], life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling electricity; apparatus for recording, transmission or reproduction of sound or images; magnetic data carriers, recording discs; compact discs, DVDs and other digital recording media; mechanisms for coin-operated apparatus; cash registers, calculating machines, data processing equipment, computers; computer software; fire-extinguishing apparatus. Chemical and medical laboratory services in the field of biotechnology and pharmaceuticals; scientific and technological services and research and design relating thereto; Industrial analysis and research services; design and development of computer hardware and software.
40.
Systems and methods for transfer and processing of biological samples
Systems and methods are described for transfer of tissue samples from a substrate to a vessel, for subsequent processing (e.g., focused acoustic treatment) within the vessel. A transfer apparatus, having a transfer end and a handle end, may be used to collect a sample material from the substrate. When the sample material is collected from the substrate, the transfer end may be placed within a vessel for treatment of the sample material while the transfer end is also located within the vessel. In some embodiments, the transfer end may be decoupled or otherwise separated from the handle end so that only the transfer end portion of the transfer apparatus is located within the vessel during treatment.
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Biomolecule extraction kits consisting primarily of reagents for research purposes, and blood collection, dry-stabilization and storage/shipping apparatus
Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Custom manufacturing in the field of nanoparticle formation for use in drug delivery systems, biotechnology, life sciences, clinical sample preparation; custom manufacturing of drug delivery systems that include nanoparticles; nanoparticles Consulting services in the fields of chemical research and development, chemical engineering and process development, biotechnology process development; pharmaceutical manufacture, nanoparticle manufacture
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples and preparations Chemical and laboratory services in the field of biotechnology and pharmaceuticals
46.
Method and apparatus for headspace control in acoustic processing of samples
Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
Methods and systems for acoustically treating material are described. Acoustic energy is emitted into a waveguide having a wall with a shape that tapers away from the acoustic source. The wall may have a substantially conical or parabolic shape. When emitted therein, the waveguide causes convergence of the acoustic energy so as to form an acoustic focal zone at a vessel. In some embodiments, a substantial portion of the acoustic focal zone is located outside of the internal volume defined by the waveguide.
G10K 11/00 - Methods or devices for transmitting, conducting or directing sound in generalMethods or devices for protecting against, or for damping, noise or other acoustic waves in general
G10K 11/28 - Sound-focusing or directing, e.g. scanning using reflection, e.g. parabolic reflectors
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
48.
Method and apparatus for shearing of genomic material using acoustic processing
Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by using a bead positioned in the sample that helps to enhance the shearing effects of acoustic energy on genomic fragments.
B02C 17/14 - Mills in which the charge to be ground is turned over by movements of the container other than by rotating, e.g. by swinging, vibrating, tilting
B02C 19/18 - Use of auxiliary physical effects, e.g. ultrasonics, irradiation, for disintegrating
A vessel holder assembly is provided. A vessel holder, for receiving one or more vessels, includes a first set of attachment features. A cap assembly, for covering the vessel(s) includes a second set of attachment features. Respective attachment features of the vessel holder and the cap assembly may be complementary, such that engagement between complementary attachment members results in an attachment between the cap assembly and the vessel holder. Such an attachment may be manually removable, or may be locked so as to require a tool, or other suitable method, for detaching the cap assembly from the vessel holder.
The present disclosure relates to a vessel configured to apply pressure greater than ambient pressure and/or provide a reduced headspace to a sample, while subject to focused acoustic treatment. Such treatment may generally result in enhanced effects of sterilization and/or other processing than if the sample is otherwise treated under ambient conditions. The sample may be a medicament that is sterilized under pressure using focused acoustic energy, where the sterilized sample is subsequently delivered to a patient. A fluid delivery cartridge may include a vessel having a transfer end opposite a plunger end. The transfer end may include a sealed cover. A plunger may be movably disposed in the vessel to accommodate entry of a liquid via piercing of the sealed cover. Upon processing (e.g., sterilizing) of the sample with focused acoustic energy, the sample may be appropriately dispensed through the pierced sealed cover.
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/24 - Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
51.
Method and apparatus for processing sample material
Methods and systems for treating material with focused acoustic energy and/or ultraviolet radiation are described. Sample material may be provided to a single batch vessel or may flow in a continuous or intermittent fashion into/out of a processing chamber within which the material is exposed to focused acoustic energy and/or ultraviolet radiation. Exposure to focused acoustics in a flow through environment may enhance the effects of the radiation on the sample material. Further, in flow-through or single batch arrangements, sample material may be retained exterior to or within a processing chamber by one or more retaining members (e.g., filter, valve, etc.) until a characteristic of the sample material reaches one or more particular criteria (e.g., physical, chemical, biological). Once the criteria of the sample material is attained (e.g., via further treatment), the material is then permitted to flow past the retaining member(s) and through the inlet or outlet of the chamber. Further, focused acoustic processing may be used to treat articles, such as the retaining member(s), rather than only sample material located within an internal processing volume of the chamber.
Methods and systems for acoustically treating material using an acoustic energy system having a movable outer surface that contacts a sample holder. The outer surface may be cylindrical and rotate about a central axis, e.g., so that a sample holder may be driven to move by the outer surface. Acoustic energy may be emitted from within the outer surface to a treatment area outside of, and near, the outer surface. Thus, a sample holder in contact with the outer surface may have a sample exposed to acoustic energy while rotation of the outer surface may move the sample holder relative to treatment area. One or more additional rollers or other components may bias the sample holder into contact with the outer surface, e.g., so the sample holder is squeezed between the outer surface and a roller or other biasing component.
Systems and methods for processing tissue samples using acoustic energy. The tissue sample may be collected and placed on a substrate (e.g., microscope slide), or other sample holder. A transfer substrate may be positioned on the other side of the sample opposite the substrate. A microscope incorporated with the acoustic treatment system may be used to view, identify and select a portion of the sample to be transferred from the initial substrate to the transfer substrate. The selected portion of the sample is exposed to focused acoustic energy while disposed between the two substrates. The focused acoustic energy has characteristics (e.g., high frequency, small focal zone) that may be effective to transfer the selected portion of the sample from the initial substrate to the transfer substrate. Such transfer may occur with little to no damage to the sample, for example, at low temperature isothermal conditions and/or little to no cavitation of or around the sample.
Method and apparatus for processing paraffin embedded samples, e.g., to disassociate paraffin from tissue components and/or other biomolecules from the paraffin. The sample may be exposed to focused acoustic energy while held in a vessel containing a non-solvent, aqueous solution. Disassociated paraffin may be emulsified into the liquid or otherwise separated from the sample.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/00 - General processes for the preparation of peptides
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples and preparations; laboratory test tubes; laboratory storage vials[ metal laboratory storage tubes] [endotracheal tubes;] blood collection vials for medical samples
56.
Method and system for acoustically treating material
Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
B01F 11/02 - Mixing by means of ultrasonic vibrations
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/24 - Stationary reactors without moving elements inside
B01F 3/08 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with liquids; Emulsifying
B01F 3/12 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with solids
57.
Method and system for acoustically treating material
Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
G01N 29/28 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details providing acoustic coupling
B01F 11/02 - Mixing by means of ultrasonic vibrations
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
B01J 19/00 - Chemical, physical or physico-chemical processes in generalTheir relevant apparatus
B01J 19/24 - Stationary reactors without moving elements inside
Method and apparatus for holding and/or treating a sample material. A sample may be positioned in a vessel and a crushing force may be applied to the sample material while in the vessel, e.g., by a plunger that is part of a cap to pulverize the sample at cryogenic temperatures. The sample holder may include an acoustic window arranged to admit acoustic energy into the vessel for acoustic treatment of the sample. A flexible film may be used at a portion of the vessel, e.g., at the acoustic window, to cooperate with a plunger for crushing a sample.
Method and apparatus for holding and/or transferring a sample material into a second holder. The sample holder may comprise a shoulder arranged on the outer surface to engage a second holder and to position a top opening of the sample holder for communication with the second holder. A sample may be expelled from a sample holder using a piston that moves from a lower portion to an upper portion of the sample holder.
G01N 1/08 - Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
G01N 1/42 - Low-temperature sample treatment, e.g. cryofixation
Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents, e.g., a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent.
B01J 2/18 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
B01F 11/02 - Mixing by means of ultrasonic vibrations
B01F 3/08 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with liquids; Emulsifying
61.
Acoustic treatment vessel and method for acoustic treatment
Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
Method and apparatus for holding and/or treating a sample material. A sample material may be positioned in a vessel between top and bottom flexible films where the flexible films are connected together by a substantially rigid support structure that surrounds the sample material. A crushing force may be applied to the sample material via the top and bottom flexible films, e.g., to pulverize the sample at cryogenic temperatures. A sample holder may have two vessels, one arranged for applying a crushing force to a first sample and another for holding a sample for other processing, such as a histology analysis.
The invention relates to a method of forming solid particles from a sample, which includes the step of exposing the sample to a focused acoustic field having an acoustic wave variable, until the solid particles achieve a desired state of particularization. The acoustic wave variable may be selected based, at least in part, on the desired state of particularization. The sample may be exposed to the focused acoustic field through a medium.
B22F 9/04 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using physical processes starting from solid material, e.g. by crushing, grinding or milling
G10K 11/26 - Sound-focusing or directing, e.g. scanning
64.
Method and system for acoustically treating material
Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window, a heat exchanger, inlet/outlet flow arrangements, an inspection window, insert elements that define a treatment volume size or shape, etc. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
G01N 29/28 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details providing acoustic coupling
65.
Method and apparatus for fragmenting nucleic acids
Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.
Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace size at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using a headspace control element positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Protein and nucleic acid preparation kits consisting primarily of reagents for scientific research purposes; reagent kits consisting primarily of non-ionic buffer reagents for non-contact, isothermal crosslinking and shearing of cell chromatin for scientific research purposes
68.
System and method for controlling an acoustic transducer
rd harmonic mode and/or to vary between three discrete modes including a forward current mode, a zero voltage loop current mode, and a freewheel current mode. An inverter circuit may be used to control the load current, e.g., so that the load current flows in a closed loop during portions of the control cycle.
A method and apparatus for exposing a sample, including a liquid and another material, to sonic energy to produce a desired result such as, suspending a material support in the liquid. The material support may be a bead or other particle with at least one surface feature to which the material may bind. Material in the liquid may attach to the material support, such as by specific or non-specific binding, entrapment or other, so as to facilitate separation of the material from the liquid. Separation of the material supports from the liquid and other unbound material may be done by allowing the material supports to settle out, e.g., under the force of gravity and/or as assisted by centrifugation, by applying a magnetic field in case the supports or material bound to the supports are movable by way of a magnetic field, or other techniques.
The present invention provides systems, methods, and devices for using acoustic energy. In some embodiments, a fluid bath may be provided in the system where the fluid bath quality may be monitored using acoustic energy. An assessment of fluid bath quality can be determined through a comparison that is made of an initial power signal of the acoustic energy with a reflected power signal of the acoustic energy.
B06B 1/00 - Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency
G01N 29/00 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
71.
Method and apparatus for treatment enhancement in acoustic processing of samples
Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by positioning a suitable element so as to reduce and/or eliminate a headspace at a sample/gas interface. An interaction between the acoustic energy and the sample may be controlled, e.g., by using an energy director positioned at least partially in the sample that helps to reduce splashing or other sample ejection that would otherwise occur.
This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples [ and preparations ] Chemical and medical laboratory services in the field of biotechnology [ and pharmaceuticals ]
75.
Methods and systems for processing samples using acoustic energy
Methods and systems for automated compound management and sample preparation using acoustic energy. In some embodiments, acoustic energy may be transmitted through a medium and a solid or semi-solid layer that is disposed adjacent to the vessel. Both the medium and the solid or semi-solid layer may couple acoustic energy from an acoustic energy source to a focal zone in close proximity to the sample in the vessel.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory equipment, namely, instruments for the acoustic manipulation of biological or chemical samples and preparations Chemical and medical laboratory services in the field of biotechnology and pharmaceuticals
77.
Methods and systems for modulating acoustic energy delivery
